TPD ID TPD NAME PubChem synonyms SMILES Subtype Fomula Target Symbol Target ID Ligase Source TPD-P58QBR Nvp-dky709 NVP-DKY709; 2291360-73-9; DKY709; 3-(5-(1-benzylpiperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; DKY-709; NVP-DKY709?; CHEMBL5077506; SCHEMBL20765247; GTPL12583; GLXC-27294; EX-A6216; AKOS040759980; AT38274; compound 5 [PMID: 36863346]; BP-28983; MS-27288; HY-144998; CS-0436652; Z6963278709; 3-[6-(1-benzylpiperidin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C4CCN(Cc5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C25H27N3O3 IKZF2 Q9UKS7 CRBN 10.1016/j.chembiol.2023.02.005 TPD-7WEF5B PROTAC BRD4 Degrader-7 PROTAC BRD4 Degrader-7; 2413382-30-4; BRD4 degrader-3; GNE11; CHEMBL5434715; SCHEMBL21846909; EX-A11422; HY-136857; CS-0134151; H38190; tert-butyl 2-[(9S)-7-[4-(3-aminoprop-1-ynyl)phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate Cc1sc2c(c1C)C(c1ccc(C#CCN)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 Degrader C26H29N5O2S BRD2;BRD4 P25440/O60885 DCAF16 10.1021/acschembio.2c00747 TPD-RNQK6K Bufalin bufalin; 465-21-4; CHEBI:517248; UNII-U549S98QLW; U549S98QLW; 3,14-Dihydroxy-bufa-20,22-dienolide; 3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide; BUFALIN [MI]; NSC 89595; BUFALIN [WHO-DD]; 3beta,14beta-dihydroxy-5beta-bufa-20,22-dienolide; BRN 5141601; DTXSID90873563; (3beta,5beta)-3,14-dihydroxybufa-20,22-dienolide; NSC-89595; 5-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one; 5beta-Bufa-20,22-dienolide, 3beta,14-dihydroxy-; 5-beta-BUFA-20,22-DIENOLIDE, 3-beta,14-DIHYDROXY-; Bufa-20,22-dienolide, 3,14-dihydroxy-, (3beta,5beta)-; Bufa-20,22-dienolide, 3,14-dihydroxy-, (3-beta,5-beta)-; Bufa-20,22-dienolide, 3,14-dihydroxy-, (3.beta.,5.beta.)-; 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta(a)phenanthren-17-yl)pyran-2-one; 3-.beta.,14-Dihydroxy-5-.beta.-bufa-20,22-dienolide; 5.beta.-Bufa-20,22-dienolide, 3.beta.,14-dihydroxy-; DTXCID701476780; 3b,14b-Dihydroxy-5b-bufa-20,22-dienolide; 3-b,14-Dihydroxy-5-b-bufa-20,22-dienolide; (3b,5b)-3,14-Dihydroxybufa-20,22-dienolide; 5beta-Bufa-20,22-Dienolide, 3beta,14-Dihydroxy-(8CI); Bufa-20,22-Dienolide, 3,14-Dihydroxy-, (3-Beta,5-Beta)-(9CI); Bufa-20,22-Dienolide, 3,14-Dihydroxy-, (3beta,5beta)-(9CI); qeebrpgzbvvinn-uhfffaoysa-n; 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one; Bufalin?; Ch'an su; BUF; Bufalin (Standard); SCHEMBL165666; CHEMBL399680; HY-N0877R; GLXC-06974; HY-N0877; BDBM50584761; HSCI1_000110; LMST01130001; MSK161316; s7821; AKOS015965454; CS-3694; FB19349; SMP2_000290; AC-20197; AC-34068; BS-17080; DA-61937; C16922; (3ss,5ss)-3,14-Dihydroxybufa-20,22-dienolide; BRD-K63606607-001-01-8; BRD-K63606607-001-02-6; Q18379323; (3beta,5beta,10alpha,17alpha)-3,14-dihydroxybufa-20,22-dienolide; (3?,5?)-3,14-Dihydroxy-bufa-20,22-dienolide;3?,14-dihydroxy-5?-bufa-20,22-dienolide C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@@]3(CC[C@@H]4C5=COC(=O)C=C5)O)C)O Degrader C24H34O4 E2F2 Q14209 ZFP91 10.1016/j.ebiom.2022.104353 TPD-1730LX CR8, (R)-Isomer (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol\; (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol; (2R)-2-{[9-(propan-2-yl)-6-({[4-(pyridin-2-yl)phenyl]methyl}amino)-9H-purin-2-yl]amino}butan-1-ol; (2R)-2-((9-(1-methylethyl)-6-((4-pyridin-2-ylbenzyl)amino)-9H-purin-2-yl)amino)butan-1-ol; (2R)-2-((9-(propan-2-yl)-6-(((4-(pyridin-2-yl)phenyl)methyl)amino)-9H-purin-2-yl)amino)butan-1-ol; 294646-77-8; CR8, (R)-Isomer; (R)-CR8; 1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2R)-; (R)?-?CR8; (R)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol; CHEMBL518800; (2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol; CR8; 3ddp; RC8; CDK inhibitor CR8; CR8 3HCl (R); CR-8; SCHEMBL13001902; GTPL11065; CR8-(R); DTXSID80436984; HMS3229B13; BDBM50154937; EX-A11115; AKOS025394606; CR8, >=95% (HPLC); DB08463; NCGC00370890-01; DA-48763; HY-18340; MS-27687; CS-0007451; NS00071534; G60966; EN300-25631346; BRD-K40331046-305-01-5; Q27097669; (R)-2-(9-Isopropyl-6-(4-(pyridin-2-yl)benzylamino)-9H-purin-2-ylamino)butan-1-ol; (2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol; CR8, (R)-Isomer CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=N4 Degrader C24H29N7O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41586-020-2374-x TPD-H36FEP Nvs-stg2 NVS-STG2; 3030588-01-0; 4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid; 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid; Y6H; STING agonist NVS-STG2; GLXC-27681; EX-A10229; HY-157214; CS-0907430; G86934 COc1cc(C(=O)O)ccc1NCc1ccc(C2(C(C)(C)C)OCC(C)(C)CO2)cc1 Stabilizer C25H33NO5 STING Q86WV6 . 10.1038/s41589-023-01434-y TPD-UYX5KC HQ461 2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide\; HQ461; 1226443-41-9; 2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide; 2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide; 2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-~{N}-(5-methyl-1,3-thiazol-2-yl)ethanamide; CHEMBL5175040; SCHEMBL24101439; EX-A6338; HQ461?; AKOS024528215; MS-25304; N-(5-methyl-1,3-thiazol-2-yl)-2-{2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl}acetamide; HY-144981; CS-0436598; VU0528787-1; G67905; EN300-37447427; F5950-0461; RPW CC1=NC(=CC=C1)NC2=NC(=CS2)CC(=O)NC3=NC=C(S3)C Degrader C15H15N5OS2 CDK12;CCNK Q9NYV4/O75909 DDB1 10.7554/eLife.59994 TPD-U7N8WL N-[2-chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide EN450; 793719-01-4; N-[2-chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide; N-(2-Chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide; N-[2-Chloro-5-[(dimethylamino)sulfonyl]phenyl]-2-propenamide; starbld0003560; EX-A7945F; GTPL12636; GLXC-27517; EN-450; EN450?; AKOS008967683; NCGC00658745-01; AS-88055; DA-63182; HY-49444; CS-0783610; G76756; EN300-7515212; Z57043669 CN(C)S(=O)(=O)C1=CC(=C(C=C1)Cl)NC(=O)C=C Degrader C11H13ClN2O3S NFKB1 P19838 UBE2D1 10.1016/j.chembiol.2023.02.008 TPD-Q90952 PMID38098458_FL2-14 . CN(CC1=NC=C(C2CC2)O1)S(=O)(=O)OC1=CC=C(NC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C=C1 Degrader C27H25N5O8S GSPT2 Q8IYD1 CRBN 10.1021/acschembio.3c00598 TPD-GP3QEF Cc-90009 Eragidomide; 1860875-51-9; CC-90009; Cereblon modulator 1; Eragidomide [INN]; 2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoroacetamide; R76M2Z6366; Compound 1 [WO2019006299A1]; compound 16 [PMID: 33591756]; 2-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl)methyl)-2,2-difluoroacetamide; Compound 1 (WO2019006299A1); compound 16 (PMID: 33591756); 2-(4-chlorophenyl)-N-{[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl]methyl}-2,2-difluoroacetamide; 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl)methyl)-2,2-difluoroacetamide; Cereblon Modulator CC-90009; CC 90009; 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide; CHEMBL4742712; CC90009; MFCD32690104; Eragidomide [WHO-DD]; Eragidomide; CC-90009; SCHEMBL17420717; UNII-R76M2Z6366; GTPL11424; GLXC-23380; BCP33889; EX-A4705; KZC87551; BDBM50557457; NSC828250; s9832; AKOS040732788; AT18065; NSC-828250; AC-37776; BP-28981; DA-51789; MS-28481; SY325383; CC-90009?; HY-130800; CS-0114090; CC90009; CC 90009; Cereblon modulator 1; Z3417355787; 2-(4-Chlorophenyl)-N-[[2-(2,6-dioxo-3-piperidyl)-1-oxoisoindolin-5-yl]methyl]-2,2-difluoroacetamide O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 Degrader C22H18ClF2N3O4 GSPT1 P15170 CRBN 10.1182/blood.2020008676 TPD-3GSS6I DA-67756 2-cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione\; 1613509-49-1; 2-cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione; SRI-41315; SCHEMBL15797052; XUOTZAUZHWCGHL-UHFFFAOYSA-N; DA-67756; SY311565; HY-150090; CS-0608650; F88879; 2-cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5-dione; ZVM CN1C2=CC=CC=C2C(=O)C3=C1N=C(N(C3=O)C4=CC=CC=C4)C5CCC5 Stabilizer C22H19N3O2 eRF1;RPS23 P62495/P62266 . 10.1038/s41589-023-01521-0 TPD-JFBQFN N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide 289483-69-8; E7820; E-7820; 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide; E 7820; N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide; Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-; TVH5K7949N; NSC-719239; N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzenesulfonamide; 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide; ER-68203-00; UNII-TVH5K7949N; LWGUASZLXHYWIV-UHFFFAOYSA-N; O6M; SCHEMBL1581157; CHEMBL4297376; DTXSID20183142; GLXC-10196; 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide; BCP25835; EX-A1818; NSC719239; NSC777573; s6628; AKOS032944953; CS-6075; DB12505; NSC-777573; SB16542; AC-36189; BS-16799; HY-14571; NS00068143; E7820?; F20780; EN300-7545157; Q27290435; Z3041516104; N-(3-cyano-4-methyl-1H -indol-7-yl)3-cyanobenzenesulfonamide CC1=C2C(=CNC2=C(C=C1)NS(=O)(=O)C3=CC=CC(=C3)C#N)C#N Degrader C17H12N4O2S RBM39 Q14498 DCAF15 10.1038/s41589-019-0378-3 TPD-PCBVIQ Vnpp433-3|A CHEMBL4591875; VNPP433-3; A; VNPP433-3beta; SCHEMBL17498770; BDBM50536418; HY-160777; CS-1047639 C[C@]12CC[C@H](n3ccnc3)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(n3cnc4ccccc43)=CC[C@@H]12 Degrader C29H34N4 AR;AR-V7 P10275/P10275-3 MDM2 10.3390/cancers15041198 TPD-EBH1OJ 1-(7-Benzyl-2,7-diazaspiro[4.4]nonan-2-yl)prop-2-en-1-one 2191110-79-7; 1-(7-Benzyl-2,7-diazaspiro[4.4]nonan-2-yl)prop-2-en-1-one; 1-{7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl}prop-2-en-1-one; SCHEMBL25809331; EN171; AKOS034007733; HY-W1005067; NCGC00659095-01; EN300-7530357; Z3616215752 C=CC(=O)N1CCC2(C1)CCN(C2)CC3=CC=CC=C3 Stabilizer C17H22N2O ERα;YAP;TAZ;14-3-3σ P03372/P46937/Q9GZV5/P31947 . 10.1101/2023.11.06.565850 TPD-0FOWA4 Indoleacetic acid indole-3-acetic acid; 87-51-4; 3-Indoleacetic acid; indoleacetic acid; Heteroauxin; 1H-Indole-3-acetic acid; 1H-indol-3-ylacetic acid; 2-(1H-Indol-3-yl)acetic acid; Rhizopin; Rhizopon A; 3-Indolylacetic acid; Indol-3-ylacetic acid; Hexteroauxin; 3-(Carboxymethyl)indole; 3-Iaa; beta-Indoleacetic acid; Acetic acid, indolyl-; Heteroauxinhexteroauxiniaa; beta-Indolylacetic acid; Indolylacetic acid; Indolyl-3-acetic acid; indole acetic acid; omega-Skatole carboxylic acid; Kyselina 3-indolyloctova; Indoleacetic acid (VAN); (1H-Indol-3-yl)-acetic acid; CCRIS 1014; EPA Pesticide Chemical Code 128915; Kyselina 3-indolyloctova [Czech]; 3-Indolylessigsaeure; 2-(3-Indolyl)acetic acid; NSC 3787; AI3-24131; 3-Indole-Acetic acid; 2-(indol-3-yl)ethanoic acid; Indolylacetate; b-Indoleacetate; b-Indolylacetate; (indol-3-yl)acetic acid; 3-Indolylacetate; beta-Indoleacetate; beta-Indolylacetate; EINECS 201-748-2; Skatole carboxylate; Indol-3-ylacetate; Indolyl-3-acetate; b-Indoleacetic acid; b-Indolylacetic acid; DTXSID5020738; CHEBI:16411; 1H-Indole-3-acetate; Skatole carboxylic acid; 6U1S09C61L; 1H-Indole-3-acetic acid (9CI); 2-(3-Indolyl)acetate; NSC-3787; beta-Indole-3-acetic acid; (1H-Indol-3-yl)-acetate; alpha-Indol-3-yl-acetic acid; DTXCID70738; Indole-3-acetic acid (8CI); INDOLEACETIC ACID [MI]; IES cpd; 3Indoleacetic acid; Indole3acetic acid; Indol3ylacetic acid; betaIndoleacetic acid; Acetic acid, indolyl; 1HIndole3acetic acid; betaIndolylacetic acid; 3(Carboxymethyl)indole; Kyselina 3indolyloctova; omegaSkatole carboxylic acid; 3Indolylmethylcarboxylic acid; 1HIndole3acetic acid (9CI); INDOLE ACETIC ACID [INCI]; inchi=1/c10h9no2/c12-10(13)5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11h,5h2,(h,12,13; auxin; IAA; indoleacetate; (indol-3-yl)acetate; MFCD00005636; (1H-Indol-3-yl)acetic acid; .alpha.-IAA; .beta.-IAA; 3-indole acetic acid; .beta.-Indoleacetic acid; .beta.-Indolylacetic acid; .beta.-Indole-3-acetic acid; CHEMBL82411; .omega.-Skatole carboxylic acid; .alpha.-Indol-3-yl-acetic acid; NSC3787; 3-indoleacetate; 2-indol-3-ylacetic acid; (1H-indol-3-yl)acetate; CAS-87-51-4; IES; SMR000471855; Indole 3-acetic acid; 3-indolyl acetic acid; UNII-6U1S09C61L; alpha-IAA; beta-IAA; IAC; Indole-3acetic acid; indole-3-acetic-acid; 3-indolyl-acetic acid; Acid, 6; 3-Indoleacetic acidIAA; Indole-3-acetic-t acid; 1H-indol-3-acetic acid; Maybridge1_006755; indole, 3-carboxymethyl-; 1H-Indole 3-acetic acid; bmse000177; Indole-3-acetic acid/IAA; 3-Indoleacetic acid, 98%; 3-Indoleacetic acid, 99%; Oprea1_602123; SCHEMBL26344; MLS001066408; MLS001331664; MLS001332399; MLS001332400; 3-Indolylmethylcarboxylic acid; WLN: T56 BMJ D1VQ; [3H]-IAA; 3-Indolyl acetic acid 100 microg/mL in Acetonitrile; SCHEMBL1641591; SCHEMBL3448734; SCHEMBL8087155; acetic acid, 2-(3-indolyl)-; HMS560L01; 2-(1H-indol-3-yl)-acetic acid; HMS2269G24; HMS3604M04; BCP26623; MSK24053; Tox21_202284; Tox21_302731; BBL009348; BDBM50201883; CCG-51070; s4799; SBB017530; STK397461; AKOS000119890; 1H-Indole-3-acetic-a-t acid (9CI); AC-2974; CG-0522; CS-6287; DB07950; FI09866; SDCCGMLS-0066204.P001; 3-Indoleacetic acid, >=98.0% (T); NCGC00247039-01; NCGC00247039-02; NCGC00247039-07; NCGC00256391-01; NCGC00259833-01; HY-18569; SY003464; DB-011566; EU-0099905; I0022; NS00014849; ST45025209; 3-Indoleacetic acid, technical, >=95% (T); EN300-17303; C00954; Q411208; SR-01000596909; 3-Indoleacetic acid, SAJ special grade, >=98.5%; IS_INDOLE-2,4,5,6,7-D5-3-ACETIC ACID; SR-01000596909-1; SR-01000596909-2; Z56913182; 2-(3-Indolyl)acetic acid 3-(Carboxymethyl)-1H-indole; 3-Indoleacetic acid, PESTANAL(R), analytical standard; F0722-8837; 0A0524AE-D755-4E91-A73A-2AD867FE676A; 3-Indoleacetic acid, plant cell culture tested, crystalline O=C(O)Cc1c[nH]c2ccccc12 Degrader C10H9NO2 IAA7 F4J2U7 TIR1 10.1038/nature05731 TPD-OTZLID NST-628 NST-628; 3002056-30-3; A1AHE; 3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(3-fluoropyridin-2-yl)oxy-4-methylchromen-2-one; SCHEMBL26613859; GTPL13370; EX-A8853; HY-158115; CS-1047734; H38918 CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=C(C=CC=N3)F)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F Stabilizer C22H18F2N4O5S ARAF;MEK1 P10398/Q02750 . 10.1158/2159-8290.CD-24-0139 TPD-T50FF4 Anagrelide anagrelide; 68475-42-3; Anagrelida; Anagrelidum; Anagrelidum [INN-Latin]; Anagrelida [INN-Spanish]; HSDB 7325; BL 416201; BRN 0619582; UNII-K9X45X0051; CHEBI:142290; 6,7-Dichlor-1,5-dihydroimidazo(2,1-b)chinazolin-2(3H)-on; 6,7-Dichloro-1,5-dihydroimidazo(2,1-b)quinazolin-2(3H)-one; K9X45X0051; Imidazo[2,1-b]quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-; Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-; Anagrelidum (INN-Latin); Anagrelida (INN-Spanish); 6,7-dichloro-1,5-dihydroimidazo[2,1-]quinazolin-2(3H)-one; 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one; 6,7-dichloro-1,5-dihydroimidazo(2,1-)quinazolin-2(3H)-one; 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2[3H]-one; DTXCID6028280; L01XX35; 6,7-Dichloro-1,5-dihydroimidazo; 6,7-dichloro-1,2,3,5-tetrahydroimidazo; dtxsid4048305; Xagrid; 6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one; Agrelin; CHEMBL760; Anagrelide(13C3); BL-4162A; Anagrelide [INN:BAN]; 6,7-dichloro-1H,2H,3H,5H-imidazolidino[2,1-b]quinazolin-2-one; 6,7-bis(chloranyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one; Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride; Anagrelide (INN/BAN); MFCD00866794; ANAGRELIDE [MI]; ANAGRELIDE [INN]; ANAGRELIDE [HSDB]; ANAGRELIDE [VANDF]; SCHEMBL9411; ANAGRELIDE [WHO-DD]; ANAGRELIDE [EMA EPAR]; BIDD:GT0711; SCHEMBL318594; GTPL7114; OTBXOEAOVRKTNQ-UHFFFAOYSA-N; HMS2089D21; HMS3715J06; HMS3742K13; BCP21314; HY-B0523; UYB53158; BDBM50000334; AKOS015899342; AKOS016340524; AC-3401; CCG-221242; DB00261; KS-5176; NCGC00161408-02; NCGC00161408-08; NCGC00247665-01; AS-14157; FA168205; SBI-0206823.P001; DB-055153; CS-0009495; NS00006904; D07455; EN300-187333; G83851; AB00698496-05; AB00698496-07; AB00698496_08; AB01566808_01; Q408163; 6,7-dichloro-3H,5H-imidazo[2,1-b]quinazolin-2-ol; BRD-K62200014-001-02-6; BRD-K62200014-003-05-5; BRD-K62200014-003-08-9; BRD-K62200014-003-10-5; BRD-K62200014-003-11-3; 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one; 6,7-dichloro-1h,5h-imidazo[2,1-b]quinazoline-2(3h)-one; 6,7-dichloro-1, 5-dihydroimidazo[2,1-b]quinazolin-2[3H]-one; 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2(3H)-one; 6,7-dichloro-1,5dihydroimidazo[2,1-b]quinazolin-2[3H]-one; 6,7-dichloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one; 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one(anagrelide); 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one(BL-4162A); J33 O=C1CN2Cc3c(ccc(Cl)c3Cl)N=C2N1 Stabilizer C10H7Cl2N3O PDE3A;SLFN12 Q14432/Q8IYM2 . 10.1021/acsmedchemlett.3c00092 TPD-5QPVXN UM171 4-N-[2-benzyl-7-(2-methyltetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine\; UM171; 1448724-09-1; UM-171; 8XZ4J0KS9C; 4-N-[2-benzyl-7-(2-methyltetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine; A1ACV; ((1R, 4R)-N1-(2-Benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido(4,5-b)indol-4-yl)cyclohexane-1,4-diamine; 1,4-Cyclohexanediamine, N1-(7-(2-methyl-2H-tetrazol-5-yl)-2-(phenylmethyl)-9H-pyrimido(4,5-b)indol-4-yl)-, trans-; trans-N1-(7-(2-Methyl-2H-tetrazol-5-yl)-2-(phenylmethyl)-9H-pyrimido(4,5-b)indol-4-yl)-1,4-cyclohexanediamine; trans-N1-[7-(2-Methyl-2H-tetrazol-5-yl)-2-(phenylmethyl)-9H-pyrimido[4,5-b]indol-4-yl]-1,4-cyclohexanediamine; UNII-8XZ4J0KS9C; CHEMBL4535214; SCHEMBL15151854; SCHEMBL18096437; SCHEMBL20953135; SCHEMBL23552414; UM-171 pound>>UM 171; DTXSID201108994; GLXC-15343; BCP23874; YHC72409; s7608; AT41606; CCG-269273; CS-7617; NCGC00384196-02; HY-12878; TS-08582; (1r,4r)-N1-(2-Benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine CN1N=C(N=N1)C2=CC3=C(C=C2)C4=C(N3)N=C(N=C4NC5CCC(CC5)N)CC6=CC=CC=C6 Degrader C25H27N9 HDAC2;HDAC1 Q92769/Q13547 KBTBD4 10.1101/2024.05.14.593897 TPD-SDDU4X CC-885 CC-885; 3-(3-chloro-4-methylphenyl)-1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]urea; 3-(3-chloro-4-methylphenyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl)methyl)urea; 1010100-07-8; N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea; 1-(3-chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea; MFCD31657329; CHEMBL4170596; 1-(3-Chloro-4-methyl-phenyl)-3-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-urea; 1-(3-Chloro-4-methylphenyl)-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl]methyl]urea; SCHEMBL61575; 1-(3-chloro-4-methylphenyl)-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]urea; GTPL9224; TQR1238; DOEVCIHTTTYVCC-UHFFFAOYSA-N; GLXC-10033; EX-A5312; KQB10007; BDBM50631119; s8300; AKOS037653341; AT11460; CC-885?; AC-37841; BP-42110; DA-72005; SY326093; HY-101488; CS-0021543; EN300-22883929; Z3417407631; 1-(3-chloro-4-methylphenyl)-3-{[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl]methyl}urea Cc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1Cl Degrader C22H21ClN4O4 GSPT1;CDK4 P15170/P11802 CRBN 10.1016/j.bbrc.2021.02.110 TPD-L7AVW8 TrkA 10.1016/j.bmcl.2019.126775 Stabilizer P04629 . PMID31699609_V1 . Nc1c(N2CC[NH+](C3CCCCC3)CC2)cc(Nc2ccc(C(=O)[O-])cc2)c2c1C(=O)c1ccccc1C2=O C31H32N4O4 TPD-W2HR7T OPB-171775 OPB-171775; 2131210-15-4; SCHEMBL20607360; GTPL13643; EX-A9729; OPB171775; Example 124 [US20190023662]; HY-162730; H40364; (4R)-3-[2,3-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one; (5R)-6-[2,3-Difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone; (R)-6-(2,3-Difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one C[C@@H]1CC(=O)NN=C1C2=C(C(=C(C=C2)OCC(C)(C)O)F)F Stabilizer C15H18F2N2O3 PDE3A;SLFN12 Q14432/Q8IYM2 . 10.1158/1078-0432.CCR-24-0096 TPD-3HGBX2 GSPT1 degrader-1 GSPT1 degrader-1; SCHEMBL29225932; EX-A11419; PD215275; HY-155552; CS-0881347; 3037491-05-4 COCCN(C)Cc1cc(NC(=O)CCc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cc(Cl)c1C Degrader C28H33ClN4O5 GSPT1 P15170 CRBN 10.1016/j.ejmech.2023.115580 TPD-G1IE4T Indisulam Indisulam; 165668-41-7; N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide; E7070; E-7070; N1-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide; indisulamum; N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide; E 7070; WJ98J3NM90; INDISULAM [INN]; INDISULAM [MI]; INDISULAM [USAN]; INDISULAM [WHO-DD]; 1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-; CHEBI:145431; DTXSID50168008; N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide; N(1)-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide; n-(3-chloro-1h-indol-7-yl)-4-sulfamoylbenzenesulfonamide; 1,4-BENZENEDISULFONAMIDE, N-(3-CHLORO-1H-INDOL-7-YL); N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide; DTXCID2090499; N-(3-Chloro-7-indoyl)-1,4-Benzenedisulfonamide; 4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide; 1,4-Benzenedisulfonamide, N1-(3-chloro-1H-indol-7-yl)-; CHEMBL77517; N~1~-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide; indisulam (e7070); UNII-WJ98J3NM90; Indisulam (IND); EF6; ER-35744; Indisulam (USAN/INN); SCHEMBL91389; Indisulam [USAN:INN:BAN]; GTPL7046; N-(3-Chloro-1H-indol-7-yl)benzene-1,4disulfonamide; Indisulam, >=98% (HPLC); BDBM10890; GLXC-01609; GLXC-10197; BCP06110; s9742; AKOS022181456; DB06370; SB16544; AC-36646; AS-69532; HY-13650; DB-064580; CS-0007710; NS00068354; C73201; D04522; EN300-7378250; BRD-K17610631-001-03-3; Q27078056; 1-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide; Z2724205552 C1=CC2=C(C(=C1)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)N)NC=C2Cl Degrader C14H12ClN3O4S2 RBM39 Q14498 DCAF15 10.1016/j.celrep.2023.113307 TPD-GOL2K4 4-methyl-N-quinolin-6-ylbenzenesulfonamide 4-methyl-N-quinolin-6-ylbenzenesulfonamide; MLS000043349; SMR000019968; 4-methyl-N-(quinolin-6-yl)benzene-1-sulfonamide; 4-METHYL-N-(QUINOLIN-6-YL)BENZENESULFONAMIDE; 253328-68-6; NSC109475; Maybridge1_002155; regid4252281; Oprea1_619472; cid_268975; SCHEMBL6978649; CHEMBL1348931; BDBM37100; HMS547J21; HMS2403F11; CCG-48190; STL445217; AKOS001694716; HS-6865; NSC-109475; 4-methyl-N-(6-quinolyl)benzenesulfonamide; 4-methyl-N-(6-quinolinyl)benzenesulfonamide; 4-methyl-N-quinolin-6-yl-benzenesulfonamide; SR-01000615228-2 Cc1ccc(S(=O)(=O)Nc2ccc3ncccc3c2)cc1 Degrader C16H14N2O2S RBM39;RBM23 Q14498/Q86U06 DCAF15 10.1021/jacs.2c10784 TPD-1MQD3N Uridine Diphosphate Glucose UDP-glucose; URIDINE DIPHOSPHATE GLUCOSE; 133-89-1; UDP-a-D-Glucose; UDP-alpha-D-Glucose; co-waldenase; UDPglucose; URIDINE-5'-DIPHOSPHATE-GLUCOSE; co-galactoisomerase; Uridine diphosphoglucose; Cogalactoisomerase; UDP glucose; Uridine 5'-(trihydrogen diphosphate), mono-alpha-d-glucopyranosyl ester; 5'-Diphosphoglucose; URIDINE-5'-DIPHOSPHOGLUCOSE; Uridine diphospho-D-glucose; UDP-Glc; UNII-V50K1D7P4Y; Uridine pyrophosphate-glucose; Diphosphate Glucose, Uridine; Uridine 5'-diphosphate glucose; V50K1D7P4Y; CHEBI:46229; EINECS 205-121-4; UDP-glucose Disodium Salt; Uridine 5'-diphospho-alpha-D-glucose; Uridine 5'-pyrophosphate glucose ester; DTXSID00157902; COGALACTOISOMERASE [WHO-DD]; URIDINE DIPHOSPHATE GLUCOSE [MI]; URIDINE DIPHOSPHATE GLUCOSE [WHO-DD]; Uridine 5'-(alpha-D-glucopyranosyl pyrophosphate); uridine 5'-[3-alpha-D-glucopyranosyl dihydrogen diphosphate]; Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-glucopyranosyl ester; URIDINE 5'-(TRIHYDROGEN DIPHOSPHATE), P'-.ALPHA.-D-GLUCOPYRANOSYL ESTER; Glucose, UDP; Diphosphoglucose, Uridine; Glucose, Uridine Diphosphate; uridine 5'-(3-alpha-D-glucopyranosyl dihydrogen diphosphate); (((2r,3s,4r,5r)-3,4-dihydroxy-5-(4-hydroxy-2-oxopyrimidin-1-yl)oxolan-2-yl)methoxy(hydroxy)phosphoryl)oxy(((3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy)phosphinic acid; {[(2r,3s,4r,5r)-3,4-dihydroxy-5-(4-hydroxy-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy([(3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy)phosphinic acid; DTXCID8080393; Uridine 5'-diphospho-I+--D-glucose; URIDINE-5'-diphosphoric acid-glucose; GLUCOSE-uridine-C1,5'-diphosphoric acid; Uridine 5'-(I+--D-glucopyranosyl pyrophosphate); Uridine 5'-(trihydrogen diphosphate), mono-a-d-glucopyranosyl ester; Uridine 5'-(trihydrogen diphosphate), p'-a-D-glucopyranosyl ester; Uridine 5'-(trihydrogen diphosphate), p'-I+--D-glucopyranosyl ester; Uridine 5'-(trihydrogen diphosphate), mono-I+--D-glucopyranosyl ester; Uridine 5'-(trihydrogen diphosphoric acid), mono-a-D-glucopyranosyl ester; Uridine 5'-(trihydrogen diphosphoric acid), mono-I+--D-glucopyranosyl ester; Uridine 5'-(trihydrogen diphosphoric acid), p'-a-D-glucopyranosyl ester; Uridine 5'-(trihydrogen diphosphoric acid), p'-alpha-D-glucopyranosyl ester; Uridine 5'-(trihydrogen diphosphoric acid), p'-I+--D-glucopyranosyl ester; Uridine 5'-(trihydrogen diphosphoric acid), mono-alpha-D-glucopyranosyl ester; uridinediphosphoglucose; UDPG; Uridine 5'-diphosphoglucose; [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate; Uridine diphosphate-glucose; GLUCOSE-URIDINE-C1,5'-DIPHOSPHATE; (UDP)glucose; UDP-delta-glucose; (UPD)-glucose; Uridindiphosphoglucose; Mono-D-glucosyl ester; UDP-alpha-delta-Glucose; 5''''-Diphosphoglucose; SCHEMBL454078; Uridine diphospho-delta-glucose; CHEMBL375951; GTPL1783; SCHEMBL28221488; Uridine-5''''-Diphosphoglucose; Uridine 5'-diphospho-a-D-glucose; URIDINE-5'-MONOPHOSPHATE GLUCOPYRANOSYL-MONOPHOSPHATE ESTER; Uridine 5-(trihydrogen diphosphate); BDBM50209659; BDBM50423218; AKOS040744389; DB01861; Uridine 5'-diphospho-alpha-delta-glucose; C00029; G64794; Q424649; Uridine 5'-pyrophosphate a-D-glucopyranosyl ester; Uridine 5'-pyrophosphate a-delta-glucopyranosyl ester; uridine 5''-[3-alpha-D-glucopyranosyl dihydrogen diphosphate]; Uridine 5'-(trihydrogen pyrophosphate), mono-D-glucosyl ester; Uridine 5'-(trihydrogen diphosphate) alpha-D-gucopyranosyl ester; Uridine 5'-pyrophosphate, alpha-D-glucopyranosyl ester (6CI,7CI); Uridine 5'-(trihydrogen diphosphate), P'-a-D-glucopyranosyl ester (9CI); Uridine 5/'-(trihydrogen diphosphate), mono-alpha-d-glucopyranosyl ester; URIDINE 5'-(TRIHYDROGEN DIPHOSPHATE), P'-.ALPHA.-D- GLUCOPYRANOSYL ESTER; Uridine 5'-(trihydrogen pyrophosphate), mono-alpha-D-glucopyranosyl ester (8CI); [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name) C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O Degrader C15H24N2O17P2 GCK P35557 CRBN 10.3390/ijms23169094 TPD-V8AZU8 Baicalin Baicalin; 21967-41-9; Baicalein 7-O-glucuronide; 7-D-Glucuronic acid-5,6-dihydroxyflavone; Baicalein 7-glucuronide; CHEBI:2981; 347Q89U4M5; 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid; 7-D-glucuronic acid-5,6-dihydroxy-flavone; UNII-347Q89U4M5; 5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide; beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl; BAICALEIN 7-O-BETA-D-GLUCURONIDE; 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid; BAICALEIN 7-O-GLUCURONIDE (USP-RS); BAICALEIN 7-O-GLUCURONIDE [USP-RS]; MFCD00134418; CHEMBL485818; BAICALIN 7-B-D-GLUCURONIDE; Baicalein 7-O-.beta.-D-glucuronide; (2S,3S,4S,5R,6R)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid; 5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl ; A-D-Glucopyranosiduronic Acid; baikalin; 0XE; ss-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl; Baicalin (6CI,7CI,8CI); Baicalein 7-O-glucuronide; Baicalein 7-O-ss-D-glucuronide; Baicalein 7-glucuronide; Baicalin (Standard); Baicalin, 95%; (2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; BAICALIN [VANDF]; Baicalein-7-D-glucuronide; BAICALIN [WHO-DD]; 31564-28-0; SCHEMBL285082; GTPL13076; HY-N0197R; TJN-151; DTXSID701346569; GLXC-10491; Baicalin, >=99.0% (HPLC); HY-N0197; MSK40031; BDBM50242173; AKOS007930529; AKOS015955933; Baicalin 1000 microg/mL in Methanol; AC-7990; CCG-214128; CS-5302; MB08110; Baicalein 7-beta-D-glucopyranosiduronate; compound 15 [PMID: 37666112]; NCGC00386028-03; (2S,3S,4S,5R,6S)-6-(5,6-DIHYDROXY-4-OXO-2-PHENYL-CHROMEN-7-YL)OXY-3,4,5-TRIHYDROXY-OXANE-2-CARBOXYLIC ACID; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-chromen-7-yl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; 1ST40031; AS-13226; PD132941; NS00097648; Q2879368; BRD-K49962337-001-01-1; Baicalin, European Pharmacopoeia (EP) Reference Standard; 5,6,7-Trihydroxyflavone-7-O-.beta.-D-glucopyranosideuronic acid; Baicalin;5,6-Dihydroxy-4-oxygen-2-phenyl-4H-1-benzopyran-7-beta-D-glucuronide; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylicacid; .BETA.-D-GLUCOPYRANOSIDURONIC ACID, 5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)O)O Stabilizer C21H18O11 RTA P02879 . 10.1074/jbc.M114.632828 TPD-BZVBBV Lutein Lutein; Bo-Xan; Vegetable lutein; all-trans-Lutein; Vegetable luteol; trans-Lutein; Lutein ester; Xantofyl; all-trans-(+)-Xanthophyll; FloraGLO; FloraGLO Lutein; Lutein, all-trans-; all-trans-Xanthophyll; Lutamax; E 161b; Oro Glo 7; Xanthophyll, all-trans-(+)-; Leutein; Lutein from tagetes erecta; OS 24; UNII-X72A60C9MT; INS NO.161B(I); X72A60C9MT; DTXSID8046749; CHEBI:28838; INS-161B(I); E 161; EINECS 204-840-0; E-161B; E-161B(I); NSC 59193; NSC-59193; DTXCID6026749; (3R,3'R,6'R)-beta,epsilon-carotene-3,3'-diol; LUTEIN (USP-RS); LUTEIN [USP-RS]; LUTEIN (MART.); LUTEIN [MART.]; NSC59193; gamma Lutein; Lutein, gamma; (3R,3'R,6R)-4,5-didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol; (1R,4R)-4-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-((4R)-4-HYDROXY-2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-3,7,12,16-TETRAMETHYL-1,3,5,7,9,11,13,15,17-OCTADECANONAEN-1-YL)-3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-OL; Leutin; Noon for Kids; (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL; (3R,3'R,6R)-4,5-DIDEHYDRO-5,6-DIHYDRO-beta,beta-CAROTIN-3,3'-DIOL; beta,beta-CAROTENE-3,3'-DIOL, 4,5-DIDEHYDRO-5,6-DIHYDRO-, (3R,3'R,6R)-; 204-840-0; 4-(18-(4-hydroxy-2,6,6-trimethyl-1-cyclohex-2-enyl)-3,7,12,16-tetramethyl-octadeca-1,3,5,7,9,11,13,15,17-nonaenyl)-3,5,5-trimethyl-cyclohex-3-en-1-ol; XANTHOPHYLL; 127-40-2; Lutein A; beta,epsilon-Carotene-3,3'-diol, (3R,3'R,6'R)-; (3R,3'R,6'R)-Lutein; beta,epsilon-Carotene-3,3'-diol; Xanthophyll (~80%); (1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1R,4R)-4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethylcyclohex-3-en-1-ol; .beta.,.epsilon.-Carotene-3,3'-diol; .beta.,.epsilon.-Carotene-3,3'-diol, (3R,3'R,6'R)-; A1LXP; (1R,4R)-4-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-((R)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl)-3,5,5-trimethylcyclohex-2-enol; 180580-60-3; Lutein; Xantofyl; NCGC00167965-01; Lutein (Standard); ()-Lutein; MFCD08435941; Lutein (Xanthophyll); Lutein - 5%; Lutein, 88%; Xanthophyll, tech grade; LEUTEIN [VANDF]; LUTEIN [VANDF]; e-carotene-3,3'-diol; Lutein - 20%; Lutein - 50%; Lutein - 95%; LUTEIN [DSC]; LUTEIN [FCC]; XANTHOPHYLL [MI]; Xanthophyll, from marigold; XANTOFYL [WHO-DD]; Lutein, analytical standard; SCHEMBL19342; 3,3'-Dihydroxy-alpha-carotene; CHEMBL173929; (invertedexclamationmarkA)-Lutein; BCBcMAP01_000190; GTPL13099; HY-N6947R; MSK1576; HMS3886I13; HY-N6947; (3R,3'R)-dihydroxy-alpha-carotene; Tox21_112594; ( inverted exclamation markA)-Lutein; BBL101804; LMPR01070274; s5103; STL555601; AKOS008901394; CCG-270087; DB00137; FX28735; SMP1_000317; AS-63011; CAS-127-40-2; FL138925; FX160846; XL176941; XL176948; CS-0015250; NS00019507; C08601; BRD-K16742848-001-01-8; BRD-K16742848-001-02-6; Q63409232; 4',5'-Didehydro-6'-hydro-.beta.-carotene-3,3'-diol #; AB972DAC-E626-49F1-898D-598AF7729FD0; Lutein, Pharmaceutical Secondary Standard; Certified Reference Material; (3R,3'R,6'R)-?,?-Carotene-3,3'-diol;?-Carotene-3,3'-diol;Xanthophyll;Lutein A; (3R,3'R,6R)-4,5-DIDEHYDRO-5,6-DIHYDRO-.BETA.,.BETA.-CAROTENE-3,3'-DIOL; (3R,3'R,6R)-4,5-DIDEHYDRO-5,6-DIHYDRO-.BETA.,.BETA.-CAROTIN-3,3'-DIOL; .BETA.,.BETA.-CAROTENE-3,3'-DIOL, 4,5-DIDEHYDRO-5,6-DIHYDRO-, (3R,3'R,6R)- CC1=C[C@H](O)CC(C)(C)[C@H]1/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C[C@@H](O)CC1(C)C Stabilizer C40H56O2 ChlG;HliD Q38833/P72932 . 10.1042/BCJ20200561 TPD-Z1X484 CC-3060 4-(1-Benzofuran-2-ylmethylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione\; CC-3060; 444288-86-2; SCHEMBL2384445; GLXC-23268; BP-42139; HY-153698; CS-0835094; 4-((Benzofuran-2-ylmethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCC4=CC5=CC=CC=C5O4 Degrader C22H17N3O5 ZBTB16 Q05516 CRBN 10.1021/acschembio.0c00674 TPD-BVQ43A GLXC-23269 4-(3-(tert-Butyl)phenoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione\; cc-647; SCHEMBL14085726; GLXC-23269; 4-(3-(tert-Butyl)phenoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 1061605-35-3 CC(C)(C)C1=CC(=CC=C1)OC2=CC=CC3=C2C(=O)N(C3=O)C4CCC(=O)NC4=O Degrader C23H22N2O5 ZBTB16 Q05516 CRBN 10.1021/acschembio.0c00674 TPD-VO0OTD bisindolylmaleimide IX bisindolylmaleimide IX; ro 31-8220; 125314-64-9; Ro31-8220; Ro-31-8220; Ro-318220; Ro 31 8220; Ro 318220; 3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propyl carbamimidothioate; CHEMBL6291; W9A0B5E78O; CHEBI:38912; 3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate; 3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl imidothiocarbamate; Carbamimidothioic acid, 3-(3-(2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl ester; Ro 31-8220 methanesulfonate;Bisindolylmaleimide IX mesylate; CHEMBL1591531; bisindolymaleimide IX; BiomolKI_000033; UNII-W9A0B5E78O; DRN; bisindolylmaleimide-IX; Bisindolylmaleimide 11b; Ro?31-8220?; ROCHE screening, 57; 3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione Methanesulfonate; BiomolKI2_000041; BIM-9; BSPBio_001077; KBioGR_000417; KBioSS_000417; BDBM3175; GTPL5259; SCHEMBL1567017; KBio2_000417; KBio2_002985; KBio2_005553; KBio3_000793; KBio3_000794; DTXSID20154736; EX-A384; DSXXEELGXBCYNQ-UHFFFAOYSA-N; Bio2_000369; Bio2_000849; GLXC-10650; HMS1792E19; HMS1990E19; HMS3401B10; HMS3403E19; HMS3673M03; AFA31464; BCP13149; NFA48918; BDBM50400734; EI-283; HY-13866A; NSC767237; AKOS030526357; CCG-100637; CS-1678; NSC-767237; SDCCGRCH-0000021.P001; IDI1_002124; NCGC00092293-02; NCGC00092293-03; NCGC00092293-04; NCGC00092293-05; NCGC00092293-15; AC-33051; DA-57490; Ro 318220 & Z-100; Q7339195; BRD-K06543683-001-04-4; BRD-K06543683-066-01-3; BRD-K06543683-066-02-1; BRD-K06543683-066-03-9; BRD-K06543683-066-04-7; BRD-K06543683-066-05-4; Ro-31-8220 - CAS 138489-18-6; 2-[3-[3-[4-(1-methylindol-3-yl)-2,5-dioxo-pyrrol-3-yl]indol-1-yl]propyl]isothiourea; 2-{1-[3-(amidinothio)propyl]-1h-indol-3-yl}-3-(1-methylindol-3-yl)maleimide; 3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propylsulfanylmethanimidamide; [(3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl)sulfanyl]methanimidamide; Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester & Z-100 CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N Stabilizer C25H23N5O2S SMAD4;SMAD3 Q13485/P84022 . 10.1016/j.chembiol.2020.11.010 TPD-7S830T PMID38795517_AN-5777 . Cc1nc2c(C)cccc2cc1C(=O)N/N=C/c1ccccc1O Degrader C19H17N3O2 GSPT1 P15170 CRBN 10.1016/j.ejmech.2024.116524 TPD-ZR06I6 PMID35717803_TD-522 1-(4-Tert-butyl-3-chlorophenyl)-3-[1-[3-(2,6-dioxopiperidin-3-yl)-4-oxo-1,2,3-benzotriazin-6-yl]ethyl]urea CC(NC(=O)Nc1ccc(C(C)(C)C)c(Cl)c1)c1ccc2nnn(C3CCC(=O)NC3=O)c(=O)c2c1 Degrader C25H27ClN6O4 GSPT1 P15170 CRBN 10.1016/j.bioorg.2022.105923 TPD-CZUEW1 (inverted exclamation markA)-BI-D 1416258-16-6; (+/-)-BI-D; ( inverted exclamation markA)-BI-D; (inverted exclamation markA)-BI-D; DL-BI-D; BID; CHEMBL4291455; 2-[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid; ALLINI; BI-D; SCHEMBL18347848; GLXC-20703; (?)-BI-D; BCP26025; (??)-BI-D; BDBM50467945; AKOS030526506; CS-3511; NCGC00390668-02; DA-68994; HY-18601; MS-26939; 2-tert-butoxy-2-(4-chroman-6-yl-2-methyl-3-quinolyl)acetic acid; BI-D; BI D;( inverted exclamation markA)-BI-D;(Inverted exclamation markA)-BI-D; (AfAE'A centa' notA inverted exclamation markAfasA'A inverted exclamation markAfAE'Adaggeratrade markAfA centA centa' notA inverted exclamation markA'A not)-BI-D CC1=NC2=CC=CC=C2C(=C1C(C(=O)O)OC(C)(C)C)C3=CC4=C(C=C3)OCCC4 Stabilizer C25H27NO4 HIV-1 Integrase P12497 . 10.1128/mbio.03560-22 TPD-2459CI SCHEMBL21638755 2-[4-(4-Chlorophenyl)-2,3,6-trimethyl-1-[(1-methylpyrazol-4-yl)methyl]pyrrolo[2,3-b]pyridin-5-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid\; SCHEMBL21638755 Cc1nc2c(c(C)c(C)n2Cc2cnn(C)c2)c(-c2ccc(Cl)cc2)c1C(OC(C)(C)C)C(=O)O Stabilizer C27H31ClN4O3 HIV-1 Integrase P12497 . 10.1128/mbio.03560-22 TPD-KW5UMU TMX-4100 TMX-4100; 2367619-63-2; CHEMBL5091525; SCHEMBL22711376; GLXC-25097; EX-A6059; AKOS040757594; DA-78516; MS-23693; HY-145321; CS-0371240; F83835; 3-(4-thiophen-3-yltriazol-1-yl)piperidine-2,6-dione; 3-[4-(3-Thienyl)-1H-1,2,3-Triazol-1-Yl]-2,6-Piperidinedione; 3-(4-(Thiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidine-2,6-dione C1CC(=O)NC(=O)C1N2C=C(N=N2)C3=CSC=C3 Degrader C11H10N4O2S PDE6D O43924 CRBN 10.1021/acs.jmedchem.1c01832 TPD-3V2A7F TMX-4116 3-[4-[4-Methoxy-5-(pyrrolidine-1-carbonyl)thiophen-3-yl]triazol-1-yl]piperidine-2,6-dione\; TMX-4116; 2766385-56-0; 3-(4-(4-Methoxy-5-(pyrrolidine-1-carbonyl)thiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidine-2,6-dione; 3-{4-[4-methoxy-5-(pyrrolidine-1-carbonyl)thiophen-3-yl]-1H-1,2,3-triazol-1-yl}piperidine-2,6-dione; CHEMBL5076661; GLXC-25098; EX-A6316; MS-26477; HY-145322; CS-0371242; G62069; EN300-43393879; 3-[4-[4-Methoxy-5-(pyrrolidine-1-carbonyl)thiophen-3-yl]triazol-1-yl]piperidine-2,6-dione COC1=C(SC=C1C2=CN(N=N2)C3CCC(=O)NC3=O)C(=O)N4CCCC4 Degrader C17H19N5O4S CK1α P48729 CRBN 10.1021/acs.jmedchem.1c01832 TPD-2FN9EL Cannabidiol cannabidiol; 13956-29-1; (-)-Cannabidiol; (-)-trans-Cannabidiol; CBD; (-)-CBD; GWP42003-P; CARDIOLRX; delta1(2)-trans-Cannabidiol; cannabidiolum; (-)-trans-2-p-Mentha-1,8-dien-3-yl-5-pentylresorcinol; UNII-19GBJ60SN5; 19GBJ60SN5; CHEBI:69478; BTX-1204; BTX-1503; GWP42003; GWP-42003-P; GWP-42003; ZYN002; Delta(1(2))-trans-cannabidiol; DTXSID00871959; Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-, (-)-(E)-; CANNABIDIOL (MART.); CANNABIDIOL [MART.]; CANNABIDIOL (USP-RS); CANNABIDIOL [USP-RS]; NanoCDB; Melody Cloverstrip; 1000mg CBD daily support; 2000mg CBD daily support; N03AX24; DTXCID401436151; leafPro CBDmed Softgels FS QP 20; leafPro CBDmed Softgels T-FS QD 20; Sativex (CBD + THC, fixed-doseoral spray); nabiximols (CBD + THC, fixed-doseoral spray); Epidiolex; Cannabidiol [USAN]; 3556-78-3; 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol; CHEMBL190461; .delta.1(2)-trans-Cannabidiol; 2-[1R-3-methyl-6R-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-, (+-)-; 1,3-Benzenediol, 2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-, (1R-trans)-; 1,3-Benzenediol, 2-(4-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-, trans-; 2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol; 2-(4-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-1,3-benzenediol trans-; (1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydrobiphenyl-2,6-diol; (-)-Cannabidiol (CBD); 1,3-benzenediol, 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-; 1,3-Benzenediol, 2-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-, (1R-trans)-; Epidiolex (TN); 1,3-BENZENEDIOL, 2-((1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL)-5-PENTYL-; Cannabidiol (7CI); (A+/-)-Cannabidiol; CANNABIDIOL [MI]; P0T; CANNABIDIOL [INN]; D1(2)-trans-Cannabidiol; CANNABIDIOL [WHO-DD]; (-)-Cannabidiol (Synthetic); SCHEMBL119679; Cannabidiol (JAN/USAN/INN); GTPL4150; 2-(6-Isopropenyl-3-methyl-2-cyclohexen-1-yl)-5-pentyl-1,3-benzenediol #; 2-(6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol; Cannabidiol, 1mg/ml in Methanol; 16 - Cannabidiol in supplements; CANNABIDIOL [ORANGE BOOK]; DTXSID301038839; 849 - Cannabidiol (CBD) in food; BDBM50121429; BDBM50318484; HB2785; AKOS032948358; DB09061; FC19666; NCGC00386518-01; (-)-Cannabidiol 1.0 mg/ml in Methanol; AC-34022; FS-10329; DB-093531; Sativex (CBD + THC, fixed-dose oral spray); C07578; D10915; nabiximols (CBD + THC, fixed-dose oral spray); Q422917; (-)-Cannabidiol (CBD) 100 microg/mL in Methanol; (-)-Cannabidiol (CBD) 1000 microg/mL in Methanol; (-)-Cannabidiol (CBD) 250 microg/mL in Acetonitrile; (3R,4R)-2-p-mentha-1,8-dien-3-yl-5-pentylresorcinol; Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-, trans-(-)- (8CI); 2-((1R,6R)-3-METHYL-6-(1-METHYLETHENYL)CYCLOHEX-2-ENYL)-5-PENTYLBENZENE-1,3-DIOL; 2-(3-methyl-6-prop-1-en-2-yl-1-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol; 2-(6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol (Cannabidiol); 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol;CBD; 2-[(1R,6R)-3-methyl-6-prop-1-en-2-yl-1-cyclohex-2-enyl]-5-pentylbenzene-1,3-diol; 2-[3-Methyl-6-(methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; (1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,6-diol; (1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro[1,1'-biphenyl]-2,6-diol; 2-((1R,6R)-3-METHYL-6-(PROP-1-EN-2-YL)CYCLOHEX-2-EN-1-YL)-5-PENTYLBENZENE-1,3-DIOL CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O Stabilizer C21H30O2 RUNX3;CBFβ Q13761/Q13951 . 10.1016/j.freeradbiomed.2024.05.047 TPD-SPNAYS Fusicoccin A Fusicoccin A C[C@@H]1[C@@H]\2CC[C@@H](/C2=C/[C@]3([C@H](CC(=C3[C@H]([C@@H]1O)O[C@@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)COC(C)(C)C=C)O)OC(=O)C)O)[C@H](C)COC(=O)C)O)C)COC Degrader C36H56O12 14-3-3σ P31947 MDM2 10.1016/j.jbc.2024.105651 TPD-SJT3DV Cdk-IN-9 CDK-IN-9; CHEMBL5194202; 3031561-92-6; 5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine; BDBM50597425; EX-A10025; HY-150641; CS-0535082; H37832; D5P NCCSc1nc(NCc2ccc(-n3cccn3)cc2)c2n[nH]c(C3CCC3)c2n1 Degrader C21H24N8S CDK12;CCNK Q9NYV4/O75909 DDB1 10.1021/acs.jmedchem.1c02184 TPD-9Y0C12 MLS000053305 6,7-dimethoxy-2-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-quinazolin-4-one\; 785708-33-0; Photoregulin3; APA modulator T4; 6,7-dimethoxy-2-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-quinazolin-4-one; SMR000067668; MLS000053305; 6,7-dimethoxy-2-[(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)methyl]-3,4-dihydroquinazolin-4-one; 6,7-dimethoxy-2-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-3H-quinazolin-4-one; Photoregulin 3; MLS002636485; CHEMBL1537680; SCHEMBL20739413; BDBM38938; cid_2092851; HMS2761J06; KGB70833; CS-0086990; EN300-7536403; SR-01000604596; SR-01000604596-3; Z44550714; 6,7-Dimethoxy-2-((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl)quinazolin-4-ol COc1cc2nc(CN3CC=C(c4ccccc4)CC3)[nH]c(=O)c2cc1OC Degrader C22H23N3O3 CCNK;CDK12 O75909/Q9NYV4 DDB1 10.1016/j.bbrc.2023.07.028 TPD-AVN0IQ SJ3149 3-[6-(1,2-benzoxazol-3-ylamino)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SJ3149; 3026986-17-1; 3-(5-(Benzo[d]isoxazol-3-ylamino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; EX-A8783; AT44762; HY-160444 C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)NC4=NOC5=CC=CC=C54 Degrader C20H16N4O4 CK1α P48729 CRBN 10.1038/s41467-024-44698-1 TPD-CUTKY4 NCT02 2-(5H,6H,7H-indeno(5,6-b)furan-3-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide\; 790245-61-3; 2-{5H,6H,7H-indeno[5,6-b]furan-3-yl}-N-(5-methyl-1,3-thiazol-2-yl)acetamide; 2-(5H,6H,7H-indeno(5,6-b)furan-3-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide; 2-(5H,6H,7H-INDENO[5,6-B]FURAN-3-YL)-N-(5-METHYL-1,3-THIAZOL-2-YL)ACETAMIDE; 840-752-4; NCT02; 2-(6,7-dihydro-5H-cyclopenta[f][1]benzofuran-3-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide; 2-(6,7-Dihydro-5H-indeno[5,6-b]furan-3-yl)-N-(5-methylthiazol-2-yl)acetamide; starbld0006156; NCT 02; NCT-02; SCHEMBL20589507; QGB24561; HY-W181530; MS-24561; CS-0242606; EN300-252755; F83184; Z29324237 CC1=CN=C(S1)NC(=O)CC2=COC3=C2C=C4CCCC4=C3 Degrader C17H16N2O2S CCNK;CDK12 O75909/Q9NYV4 DDB1 10.1016/j.celrep.2021.109394 TPD-YANNI5 RO-2443 (5Z)-5-[(6-Chloro-7-methyl-1H-indol-3-yl)methylidene]-3-[(3,4-difluorophenyl)methyl]imidazolidine-2,4-dione\; RO-2443; SCHEMBL21387150; SCHEMBL29234480; GLXC-22126; (5z)-5-[(6-Chloro-7-Methyl-1h-Indol-3-Yl)methylidene]-3-(3,4-Difluorobenzyl)imidazolidine-2,4-Dione; 1416663-79-0; RO2443; Q27449818; (5Z)-5-[(6-Chloro-7-methyl-1H-indol-3-yl)methylidene]-3-[(3,4-difluorophenyl)methyl]imidazolidine-2,4-dione CC1=C(C=CC2=C1N=CC2=CC3=C(N(C(=O)N3)CC4=CC(=C(C=C4)F)F)O)Cl Stabilizer C20H14ClF2N3O2 MDMX;MDM2 O15151/Q00987 . 10.1073/pnas.1203789109 TPD-59DHLD Nitroflurbiprofen Nitroflurbiprofen; 158836-71-6; Flurbinitroxybutylester; HCT-1026; CHEBI:77428; HCT1026; UNII-Q8ERI3E76F; FLURBINITROXY BUTYL ESTER; 4-(Nitrooxy)butyl 2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetate; NCX-1026; 4-(nitrooxy)butyl 2-(2-fluorobiphenyl-4-yl)propanoate; HCT 1026; NO-Releasing Flurbiprofen; Nitroxybutyl flurbiprofen; NO-flurbiprofen; Q8ERI3E76F; HCT 1206;NO-flurbiprofen;Nitroxybutyl flurbiprofen; 4-(nitrooxy)butyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate; Flurbiprofen nitroxybutyl ester; SCHEMBL135465; 4-nitrooxybutyl 2-(3-fluoro-4-phenylphenyl)propanoate; CHEMBL1766388; DTXSID30936005; GLXC-03407; HY-U00013; AKOS040742307; CS-6575; (1,1'-Biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-, 4-(nitrooxy)butyl ester; MS-25722; G12809; Q27146958; 4-(Nitrooxy)butyl 2-(2-fluoro[1,1'-biphenyl]-4-yl)propanoate; (1,1'-BIPHENYL)-4-ACETIC ACID, 2-FLUORO-.ALPHA.-METHYL-, 4-(NITROOXY)BUTYL ESTER CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)OCCCCO[N+](=O)[O-] Stabilizer C19H20FNO5 PD-L1 Q9NZQ7 . 10.1016/j.bcp.2020.114042 TPD-C00IFX BI-3802 2-[6-[[5-Chloranyl-2-[(3~{s},5~{r})-3,5-Dimethylpiperidin-1-Yl]pyrimidin-4-Yl]amino]-1-Methyl-2-Oxidanylidene-Quinolin-3-Yl]oxy-~{n}-Methyl-Ethanamide\; BI-3802; 2166387-65-9; CHEMBL4640049; 2-[6-[[5-chloro-2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxoquinolin-3-yl]oxy-N-methylacetamide; cis-2-((6-((5-chloro-2-(3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide; 2-((6-((5-Chloro-2-((3S,5R)-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide; 2-[6-[[5-Chloranyl-2-[(3~{s},5~{r})-3,5-Dimethylpiperidin-1-Yl]pyrimidin-4-Yl]amino]-1-Methyl-2-Oxidanylidene-Quinolin-3-Yl]oxy-~{n}-Methyl-Ethanamide; U52; SCHEMBL20284059; GTPL11338; EX-A3703; BDBM50545525; BI3802; AKOS040758744; AC-31541; DA-71468; MS-29018; HY-108705; CS-0030135; G16366; EN300-24196330; Z3476101182; 2-(6-(5-Chloro-2-(cis-3,5-dimethylpiperidin-1-yl)pyrimidin-4-ylamino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yloxy)-N-methylacetamide; 2-{[6-({5-chloro-2-[(3R,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl}amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl]oxy}-N-methylacetamide; 2408220-83-5 C[C@@H]1C[C@@H](CN(C1)C2=NC=C(C(=N2)NC3=CC4=C(C=C3)N(C(=O)C(=C4)OCC(=O)NC)C)Cl)C Stabilizer C24H29ClN6O3 BCL6 P41182 . 10.1038/s41586-020-2925-1 TPD-MN1BRU Pyrrolidone1 pyrrolidone1 C1=CC=C(C=C1)C(=C2C(N(C(=O)C2=O)C3=CC(=C(C=C3)O)C(=O)O)C4=CC=C(C=C4)[N+](=O)[O-])O Stabilizer C24H16N2O8 14-3-3-like protein E;PMA2 O49997/P19657 . 10.1002/anie.200907203 TPD-9LTVEB N-[(2r,3r)-3-Amino-2-Hydroxy-4-Phenylbutanoyl]-L-Leucine epibestatin; CHEMBL90621; N-[(2r,3r)-3-Amino-2-Hydroxy-4-Phenylbutanoyl]-L-Leucine; Lopac0_000469; SCHEMBL5819609; VGGGPCQERPFHOB-HZSPNIEDSA-N; BDBM50010205; CCG-204561; SDCCGSBI-0050454.P002; NCGC00162164-01; NCGC00162164-02; Q27459897; N-(3R-Amino-2S-hydroxy-1-oxo-4-phenylbutyl)-L-leucine CC(C)C[C@@H](C(=O)O)NC(=O)[C@@H]([C@@H](CC1=CC=CC=C1)N)O Stabilizer C16H24N2O4 14-3-3-like protein E;PMA2 O49997/P19657 . 10.1002/anie.200907203 TPD-4K904O NRX-1933 2-oxo-N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-pyridine-3-carboxamide\; NRX-1933; 2763260-30-4; 2-oxo-N-[3-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide; GLXC-20958; NRX-1933?; AKOS040758863; MS-25408; HY-144984; CS-0436614; J8Y; N-(3-(1H-Tetrazol-5-yl)phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide C1=CC(=CC(=C1)NC(=O)C2=CC=C(NC2=O)C(F)(F)F)C3=NNN=N3 Degrader C14H9F3N6O2 β-Catenin P35222 β-TrCP 10.1038/s41467-019-09358-9 TPD-OGMJJO NRX-1532 NRX-1532; GLXC-20957; MS-25359; HY-144982; CS-0436612; ?-catenin:?-TrCP interaction enhancer NRX-1532; Z395890944; 2-oxo-N-[3-(1H-pyrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-pyridine-3-carboxamide; N-(3-(1H-Pyrazol-5-yl)phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide C1=CC(=CC(=C1)NC(=O)C2=CC=C(NC2=O)C(F)(F)F)C3=CC=NN3 Degrader C16H11F3N4O2 β-Catenin P35222 β-TrCP 10.1038/s41467-019-09358-9 TPD-WBJSWU NRX-2663 3-{[2-Oxo-4-phenoxy-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid\; NRX-2663; 2763260-34-8; 3-{[2-oxo-4-phenoxy-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid; NRX2663; NRX2663?; EX-A11412; MS-27301; HY-141448; CS-0169463; G18213; 3-[[2-oxo-4-phenoxy-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]amino]benzoic acid; J8V C1=CC=C(C=C1)OC2=C(C(=O)NC(=C2)C(F)(F)F)C(=O)NC3=CC=CC(=C3)C(=O)O Degrader C20H13F3N2O5 β-Catenin P35222 β-TrCP 10.1038/s41467-019-09358-9 TPD-EZCI8K NRX-103094 3-({4-[(2,6-Dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid\; NRX-103094; 2763260-36-0; 3-({4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid; 3-(4-((2,6-dichlorophenyl)thio)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamido)benzoic acid; GLXC-27095; NRX-103094?; TS-09300; HY-141449; CS-0169464; G18214; EN300-43393893; 3-[[4-(2,6-dichlorophenyl)sulfanyl-2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]amino]benzoic acid; 3-{4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-amido}benzoic acid; J97 C1=CC(=CC(=C1)NC(=O)C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl)C(=O)O Degrader C20H11Cl2F3N2O4S β-Catenin P35222 β-TrCP 10.1038/s41467-019-09358-9 TPD-ZFGGFF NRX-103095 NRX-103095; 2763260-38-2; MS-29805; HY-141450; CS-0169466; G18215; 4-(2,6-dichlorophenyl)sulfanyl-N-[3-(dimethylcarbamoyl)phenyl]-2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carboxamide CN(C)C(=O)C1=CC(=CC=C1)NC(=O)C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl Degrader C22H16Cl2F3N3O3S β-Catenin P35222 β-TrCP 10.1038/s41467-019-09358-9 TPD-FJZ4T1 NRX-252114 2-(4-((2,6-Dichlorophenyl)thio)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl)isoindoline-4-carbonitrile\; NRX-252114; 2763260-39-3; 2-(4-((2,6-dichlorophenyl)thio)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl)isoindoline-4-carbonitrile; GLXC-20955; NRX-252114?; MS-29470; HY-111836; CS-0093150; G17943 C1C2=C(CN1C(=O)C3=C(C=C(NC3=O)C(F)(F)F)SC4=C(C=CC=C4Cl)Cl)C(=CC=C2)C#N Degrader C22H12Cl2F3N3O2S β-Catenin P35222 β-TrCP 10.1038/s41467-019-09358-9 TPD-W2H9MC NRX-252262 4-((2,6-dichlorophenyl)thio)-3-(5,6-dimethoxyisoindoline-2-carbonyl)-6-(trifluoromethyl)pyridin-2(1H)-one\; NRX-252262; 2438637-61-5; 2(1H)-one; 4-((2,6-dichlorophenyl)thio)-3-(5,6-dimethoxyisoindoline-2-carbonyl)-6-(trifluoromethyl)pyridin-2(1H)-one; 4-((2,6-Dichlorophenyl)thio)-3-(5,6-dimethoxy-; 4-(2,6-Dichlorophenyl)sulfanyl-3-(5,6-dimethoxy-1,3-dihydroisoindole-2-carbonyl)-6-(trifluoromethyl)-1H-pyridin-2-one; 4-((2,6-Dichlorophenyl)thio)-3-(5,6-dimethoxy- isoindoline-2-carbonyl)-6-(trifluoromethyl)pyridin- 2(1H)-one; 4-[(2,6-dichlorophenyl)sulfanyl]-3-(5,6-dimethoxy-2,3-dihydro-1H-isoindole-2-carbonyl)-6-(trifluoromethyl)-1,2-dihydropyridin-2-one; GLXC-20956; EX-A5657; NXD63761; AKOS040759708; NRX-252262?; MS-30010; HY-111760; CS-0090796; G16675; isoindoline-2-carbonyl)-6-(trifluoromethyl)pyridin- COC1=C(C=C2CN(CC2=C1)C(=O)C3=C(C=C(NC3=O)C(F)(F)F)SC4=C(C=CC=C4Cl)Cl)OC Degrader C23H17Cl2F3N2O4S β-Catenin P35222 β-TrCP 10.1038/s41467-019-09358-9 TPD-LFALJQ 4-Chloranyl-1-benzothiophene-2-carboximidamide 4-chloranyl-1-benzothiophene-2-carboximidamide; SCHEMBL13709497; KTW N=C(N)c1cc2c(Cl)cccc2s1 Stabilizer C9H7ClN2S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-1FN76H 5-Phenylthiophene-2-carboximidamide 5-phenylthiophene-2-carboximidamide; EN300-1876809; 2228712-64-7; KLE N=C(N)c1ccc(-c2ccccc2)s1 Stabilizer C11H10N2S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-NWAY2Y 5-Azanyl-4-phenyl-thiophene-2-carboximidamide 5-azanyl-4-phenyl-thiophene-2-carboximidamide; K48 N=C(N)c1cc(-c2ccccc2)c(N)s1 Stabilizer C11H11N3S 14-3-3σ;TAZ P31947/Q9GZV5 . 10.1021/acs.jmedchem.9b01942 TPD-3PFHZD 7-(1-Aminopropan-2-ylamino)-1-benzothiophene-2-carboximidamide CHEMBL4636206 CC(CN)Nc1cccc2cc(C(=N)N)sc12 Stabilizer C12H16N4S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-LPKOML PD194446 4-(1-Aminopropan-2-ylamino)-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide\; CHEMBL4645538; PD194446 CC(CN)Nc1cc(CS)cc2sc(C(=N)N)cc12 Stabilizer C13H18N4S2 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-TQA2XB 5-(1~{H}-imidazol-5-yl)-4-phenyl-thiophene-2-carboximidamide 5-(1~{H}-imidazol-5-yl)-4-phenyl-thiophene-2-carboximidamide; CHEMBL4633331; KLB N=C(N)c1cc(-c2ccccc2)c(-c2c[nH]cn2)s1 Stabilizer C14H12N4S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-92DTWO CHEMBL4647262 N-(2-aminoethyl)-2-carbamimidoyl-7-propan-2-yloxy-1-benzothiophene-4-carboxamide\; CHEMBL4647262 CC(C)Oc1ccc(C(=O)NCCN)c2cc(C(=N)N)sc12 Stabilizer C15H20N4O2S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-1S2B5E MERS-CoV N-NTD 10.1021/acs.jmedchem.9b01913 Stabilizer K9N4V7 . 135829-04-8 Benzyl 2-(Hydroxymethyl)-1-Indolinecarboxylate O=C(OCC1=CC=CC=C1)N1C2=CC=CC=C2CC1CO C17H17NO3 TPD-LAEQUR MERS-CoV N-NTD 10.1021/acs.jmedchem.9b01913 Stabilizer K9N4V7 . etodolac Etodolic acid CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O C17H21NO3 TPD-CYUYFJ PMID35739107_CY0072424 . N=C(N)NCCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCN)NC1=O Stabilizer C34H44N8O4S 14-3-3β;CFTR P31946/P13569 . 10.1038/s41467-022-31206-6 TPD-RT3T0Y BMS-202 N-{2-[({2-Methoxy-6-[(2-Methyl[1,1'-Biphenyl]-3-Yl)methoxy]pyridin-3-Yl}methyl)amino]ethyl}acetamide\; 1675203-84-5; BMS-202; PD1-PDL1 inhibitor 2; BMS202; Acetamide, N-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]-; N-(2-(((2-Methoxy-6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)pyridin-3-yl)methyl)amino)ethyl)acetamide; N-{2-[({2-Methoxy-6-[(2-Methyl[1,1'-Biphenyl]-3-Yl)methoxy]pyridin-3-Yl}methyl)amino]ethyl}acetamide; PD-L1 inhibitor 1; CHEMBL4089730; N-[2-({[2-methoxy-6-({2-methyl-[1,1'-biphenyl]-3-yl}methoxy)pyridin-3-yl]methyl}amino)ethyl]acetamide; BMS202 (PD-1/PD-L1 inhibitor 2); N-[2-[[2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl]methylamino]ethyl]acetamide; N-{2-[({2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide; PD-1/PD-L1 inhibitor 2; N-(2-{[2-Methoxy-6-(2-methyl-biphenyl-3-ylmethoxy)-pyridin-3-ylmethyl]-amino}-ethyl)-acetamide; MFCD29905455; KDA2HUE7KP; GTPL9607; SCHEMBL16566296; ASC20384; BCP16068; EX-A1330; US9872852, Example 202; BDBM50239947; s7912; AKOS030524803; CCG-264732; CS-5441; SB19679; compound 1c [PMID: 28613862]; BMS-202; PD-1/PD-L1 inhibitor 2; PD-1/PD-L1 inhibitor 2(BMS-202); AS-74801; DA-66535; HY-19745; PD-1/PD-L1 inhibitor 2(BMS-202)?; C73225; Q27456392; 6GX; N-[2-[[[2-Methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]acetamide CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC(=C(C=C3)CNCCNC(=O)C)OC Stabilizer C25H29N3O3 PD-L1 Q9NZQ7 . 10.18632/oncotarget.8730 TPD-G5SRU3 (S)-2-amino-4-(4-((3,4-dichlorobenzyl)oxy)phenyl)-2-methylbutan-1-ol P053; 2748196-63-4; (S)-2-amino-4-(4-((3,4-dichlorobenzyl)oxy)phenyl)-2-methylbutan-1-ol; CHEMBL5268405; (2S)-2-amino-4-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2-methylbutan-1-ol; BDBM50407245; AKOS040733943; MS-25505; HY-126015; CS-0090241; G18344 C[C@@](N)(CO)CCc1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 Stabilizer C18H21Cl2NO2 PD-L1 Q9NZQ7 . 10.3390/ph15050613 TPD-RC4V3F CRT5 3-[6-amino-5-(6-ethoxynaphthalen-2-yl)pyridin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide\; CRT5; 1034297-58-9; 3-[6-amino-5-(6-ethoxynaphthalen-2-yl)pyridin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide; CRT5 (CRT0066051); CHEMBL5419827; 3-[6-Amino-5-(6-ethoxy-2-naphthalenyl)-3-pyridinyl]-N-[2-(dimethylamino)ethyl]-benzamide; 3-(6-amino-5-(6-ethoxynaphthalen-2-yl)pyridin-3-yl)-N-(2-(dimethylamino)ethyl)benzamide; CRT5?; SCHEMBL1679215; GLXC-03751; EX-A4817; CRT5(CRT0066051); BDBM50616058; AKOS037653206; GS-1314; DA-52141; HY-112547; CS-0046344; F86419 CCOC1=CC2=C(C=C1)C=C(C=C2)C3=C(N=CC(=C3)C4=CC(=CC=C4)C(=O)NCCN(C)C)N Stabilizer C28H30N4O2 PD-L1 Q9NZQ7 . 10.3390/ph15050613 TPD-QQJ9IU CC0651 4,5-Dideoxy-5-(3',5'-Dichlorobiphenyl-4-Yl)-4-[(Methoxyacetyl)amino]-L-Arabinonic Acid\; CC0651; 1319207-44-7; CC 0651; (2R,3S,4S)-5-[4-(3,5-dichlorophenyl)phenyl]-2,3-dihydroxy-4-[(2-methoxyacetyl)amino]pentanoic acid; 4,5-Dideoxy-5-(3',5'-Dichlorobiphenyl-4-Yl)-4-[(Methoxyacetyl)amino]-L-Arabinonic Acid; (2R,3S,4S)-5-(3',5'-Dichloro-[1,1'-biphenyl]-4-yl)-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid; U94; C20H21Cl2NO6; CHEMBL1738913; SCHEMBL14884531; GLXC-04402; UCC20744; NSC793855; AKOS027470144; NSC-793855; DA-72004; HY-15301; MS-27956; F85000; Q27466832; L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]- COCC(=O)N[C@@H](CC1=CC=C(C=C1)C2=CC(=CC(=C2)Cl)Cl)[C@@H]([C@H](C(=O)O)O)O Stabilizer C20H21Cl2NO6 CDC34A;UBC P49427/P0CG48 . 10.1021/acs.bioconjchem.4c00345 TPD-PQHOHR Tafamidis TAFAMIDIS; 594839-88-0; Vyndamax; FX-1006; 2-(3,5-Dichlorophenyl)-1,3-Benzoxazole-6-Carboxylic Acid; tafamidisum; 8FG9H9D31J; CHEBI:78538; UNII-8FG9H9D31J; 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid; FX1006; FX-1005; DTXSID00208185; 6-Benzoxazolecarboxylic acid, 2-(3,5-dichlorophenyl)-; TAFAMIDIS (MART.); TAFAMIDIS [MART.]; DTXCID20130676; N07XX08; fx-006; 2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid; 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid; MFCD16621109; 594839-88-0 (free acid); C14H7Cl2NO3; Tafamidis [USAN]; Tafamidis [USAN:INN]; 4his; tafamidis-meglumine; Vyndamax (TN); 3MI; 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic Acid; Vynmac (TN); Tafamidis;Fx 1006; TAFAMIDIS [INN]; TAFAMIDIS [JAN]; TAFAMIDIS [MI]; TAFAMIDIS [WHO-DD]; Tafamidis (JAN/USAN/INN); SCHEMBL442508; GTPL8378; TAFAMIDIS [ORANGE BOOK]; CHEMBL2103837; PF-06291826(Tafamidis); PF-06291826(Tafamidis)?; GLXC-10770; HMS3741E09; HMS5085B06; BCP29089; EX-A3575; BDBM50197883; s6465; AKOS017550076; DB11644; FD27988; VS-0125; NCGC00390731-01; 137464-18-7; HY-14852; SY217402; DB-072645; NS00072572; C75776; D09673; EN300-307185; Q519447; BRD-K23728141-001-01-2; Z1443584665; 2-(3,5-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid; 6-Benzoxazolecarboxylic acid, 2-(3,5-dichlorophenyl)-; 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid; Fx 1006; Tafamidis; Vyndaqel C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl Stabilizer C14H7Cl2NO3 TTR P02766 . 10.1073/pnas.1121005109 TPD-4AM3TL Bromocriptine bromocriptine; Bromocryptine; Bromocriptin; Bromoergocryptine; Bromergocryptine; Bromoergocriptine; 2-Bromo-alpha-ergocryptine; Bromocriptina; Bromocriptinum; 2-Bromo-alpha-ergokryptine; Ergoset; 2-Bromo-alpha-ergokryptin; Ergocryptine, 2-bromo-; Bromocriptinum [INN-Latin]; Bromocriptina [INN-Spanish]; 2-Bromoergocryptine; CCRIS 3244; EINECS 247-128-5; UNII-3A64E3G5ZO; 3A64E3G5ZO; CHEBI:3181; DTXSID1022687; SANDOZ 15-754; Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'alpha)-; 2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-alpha-(2-methylpropyl)ergotamin-3',6',18-trione; DTXCID602687; Bromocryptin; (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman; (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione; 2-Bromoergokryptine; 2 Bromo alpha ergocryptine; Bromocriptinum (INN-Latin); (5'alpha)-2-bromo-12'-hydroxy-5'-(2-methylpropyl)-2'-(propan-2-yl)-3',6',18-trioxoergotaman; (5'alpha)-2-bromo-12'-hydroxy-5'-isobutyl-2'-isopropyl-3',6',18-trioxoergotaman; Bromocriptina (INN-Spanish); 2 Bromoergocryptine; 2 Bromoergokryptine; 2 Bromo alpha ergokryptine; Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'alpha-(2-methylpropyl)-; G02CB01; N04BC01; 247-128-5; 25614-03-3; CB-154; Bromocriptine (mesylate); (+)-Bromocriptine; CB 154; 22260-51-1; (6aR,9R)-5-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide; Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'.alpha.)-; 2-Bromo-.alpha.-ergocryptine; NSC169774; Bromocriptine (USAN/INN); Bromokryptine; SR-01000075356; Bromocriptine [USAN:INN:BAN]; NCGC00024584-03; 08Y; Bromocriptine+ (GTP-); Prestwick0_000121; Prestwick1_000121; Prestwick2_000121; BROMOCRIPTINE [MI]; Biomol-NT_000005; CHEMBL493; GTPL35; BROMOCRIPTINE [INN]; BROMOCRIPTINE [USAN]; Lopac0_000171; SCHEMBL25297; BROMOCRIPTINE [VANDF]; BIDD:GT0464; SPBio_002101; BROMOCRIPTINE [WHO-DD]; BPBio1_001131; BDBM81993; Tox21_110907; PDSP2_001500; AKOS015961273; CCG-204266; DB01200; SDCCGSBI-0050159.P003; NCGC00024584-04; NCGC00024584-05; NCGC00024584-07; NCGC00024584-09; NCGC00024584-17; (6aR,9R)-5-Bromo-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide; AC-13601; AC-37665; DA-61890; NCI60_001365; CAS-25614-03-3; CS-0012283; NS00001292; C06856; D03165; EN300-19768234; Q413581; SR-01000075356-5; BRD-K14496212-001-01-1; BRD-K14496212-066-02-2; BRD-K14496212-066-04-8; SAN 15-754; Sandoz 15-754; -Bromocryptine; -Bromoergocryptine; -Ergolactin; (4R,7R)-10-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-(propan-2-yl)-3-oxa-6,9-diazatricyclo[7.3.0.0^{2,6}]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(15),2,9,12(16),13-pentaene-4-carboxamide; (4R,7R)-10-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-(propan-2-yl)-3-oxa-6,9-diazatricyclo[7.3.0.0^{2,6}]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide; (5alpha,5'beta)-2-bromo-12'-hydroxy-5'-(2-methylpropyl)-3',6',18-trioxo-2'-(propan-2-yl)ergotaman; N-[(2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxo-8,9,10,10a-tetrahydro-5H-oxazolo[[?]]pyrrolo[[?]]pyrazin-2-yl]-bromo-methyl-[?]carboxamide CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 Stabilizer C32H40BrN5O5 p53;USP7 P04637/Q93009 . 10.1016/j.scib.2024.04.017 TPD-EQXRZ7 CHEMBL5182124 (6S)-9-benzyl-4-oxa-2,9-diazatricyclo[9.4.0.02,6]pentadeca-1(15),11,13-trien-3-one\; CHEMBL5182124; NCGC00394099-01 O=C1OC[C@@H]2CCN(Cc3ccccc3)Cc3ccccc3N12 Stabilizer C19H20N2O2 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-AMC1OL CHEMBL5193369 (6S)-14-fluoro-9-propan-2-yl-4-oxa-2,9-diazatricyclo[9.4.0.02,6]pentadeca-1(11),12,14-trien-3-one\; CHEMBL5193369 CC(C)N1CC[C@H]2COC(=O)N2c2cc(F)ccc2C1 Stabilizer C15H19FN2O2 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-B5KR2E PMID34667951_3 . COc1ccc(C(=O)N2C[C@@H]3CN(CCO3)C(=O)C3C[C@@H](CN3Cc3cccnc3)NC(=O)C[C@@H]3O[C@H](C2)[C@@H](O)[C@H]3O)cc1 Stabilizer C31H39N5O8 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-3KUOHW CHEMBL5182094 (3S,6S,10S,11R,12S,13R,17R)-4-(1,3-benzodioxol-5-ylmethyl)-11,12-dihydroxy-15-(4-methoxybenzoyl)-18,22-dioxa-1,4,7,15-tetrazatetracyclo[15.3.1.13,6.110,13]tricosane-2,8-dione\; CHEMBL5182094 COc1ccc(C(=O)N2C[C@@H]3CN(CCO3)C(=O)[C@@H]3C[C@@H](CN3Cc3ccc4c(c3)OCO4)NC(=O)C[C@@H]3O[C@H](C2)[C@@H](O)[C@H]3O)cc1 Stabilizer C33H40N4O10 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-XKXXE1 PMID34667951_5 . CC1=CCC2COC(CC3(C)CCCCC3)C1C2 Stabilizer C17H28O 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-PNTDM4 PMID34667951_6 . COc1ccc2c(c1)[C@]1(CCC(C)(C)CC(=O)OC(C)(C)C)CCCC[C@@H]1C=C2 Stabilizer C26H38O3 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-PKT1A5 3-Pyridin-4-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole YU142670; 133847-06-0; 3-pyridin-4-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole; 3-(4-Pyridinyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole; 3-(pyridin-4-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole; CHEMBL5173714; SCHEMBL19625697; GLXC-10374; IFA84706; STK883823; AKOS001845164; CCG-144579; HY-120354; YU142670, >=98% (HPLC); AO-365/43113532; Z2417577074; YU142670, YU 142670, YU-142670; 3-(4-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole c1cc(-c2nnc3scnn23)ccn1 Stabilizer C8H5N5S 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-BPKF2E STK506589 1-({6-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl}methyl)-1H-benzimidazole\; 791806-06-9; 1-({6-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl}methyl)-1H-benzimidazole; [3-(1H-benzimidazol-1-ylmethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]methyl 4-fluorophenyl ether; 3-(benzimidazol-1-ylmethyl)-6-[(4-fluorophenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole; CHEMBL5179770; STK506589; AKOS000651980; CCG-144690; AO-365/43113350; SR-01000154085; SR-01000154085-1; 1-({6-[(4-FLUOROPHENOXY)METHYL]-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL-3-YL}METHYL)-1H-1,3-BENZODIAZOLE Fc1ccc(OCc2nn3c(Cn4cnc5ccccc54)nnc3s2)cc1 Stabilizer C18H13FN6OS 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-VC0ZEK 3-(2-Methoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole CHEMBL5175864 COc1ccccc1-c1nnc2scnn12 Stabilizer C10H8N4OS 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-61KVG5 STK242454 6-methyl-3-(2-methyl-3-furyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine\; 6-methyl-3-(2-methyl-3-furyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine; 6-methyl-3-(2-methylfuran-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine; CHEMBL5203564; STK242454; AKOS000656452; CCG-174736; AO-365/43368476 CC1=Nn2c(nnc2-c2ccoc2C)SC1 Stabilizer C10H10N4OS 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-T04VRE CHEMBL5192059 4-[2-[7-amino-2-(5-methylfuran-2-yl)-5H-pyrrolo[3,4-b]pyridin-5-yl]ethyl]phenol\; CHEMBL5192059 Cc1ccc(-c2ccc3c(n2)C(=N)NC3CCc2ccc(O)cc2)o1 Stabilizer C20H19N3O2 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-YIW1S6 CHEMBL5198137 N-(2-methylpropyl)-1-oxo-2-propan-2-yl-3,4-dihydropyrazino[1,2-a]benzimidazole-8-carboxamide\; CHEMBL5198137 CC(C)CNC(=O)c1ccc2c(c1)nc1n2CCN(C(C)C)C1=O Stabilizer C18H24N4O2 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-PP192J 5-Benzotriazol-1-ylmethyl-[1,3,4]oxadiazole-2-thiol 5-Benzotriazol-1-ylmethyl-[1,3,4]oxadiazole-2-thiol; Maybridge4_001896; CHEMBL4894192; HMS1526G04; CCG-56478; STL266290; STL272867; AKOS000567804; AKOS022140135; 136715-68-9; NS00018252; ST50401142; AG-690/40697393; 5-(benzotriazolylmethyl)-1,3,4-oxadiazole-2-thiol; SR-01000645431-1; BRD-K67115492-001-01-4; BRD-K67115492-001-02-2; 5-(1H-benzotriazol-1-ylmethyl)-1,3,4-oxadiazole-2-thiol; 5-(1H-benzotriazol-1-ylmethyl)-1,3,4-oxadiazole-2(3H)-thione; 5-(1H-1,2,3-benzotriazol-1-ylmethyl)-1,3,4-oxadiazol-2-yl hydrosulfide Sc1nnc(Cn2nnc3ccccc32)o1 Stabilizer C9H7N5OS 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-P6V7ZE STK339202 N-(3,4-dichlorophenyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide\; N-(3,4-dichlorophenyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide; CHEMBL5201256; STK339202; AKOS000554741; N-(3,4-dichlorophenyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl]acetamide; ST50011213; AN-329/42286240; N-(3,4-dichlorophenyl)-2-[3-(trifluoromethyl)(1H-4,5,6,7-tetrahydroindazolyl)] acetamide O=C(Cn1nc(C(F)(F)F)c2c1CCCC2)Nc1ccc(Cl)c(Cl)c1 Stabilizer C16H14Cl2F3N3O 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-751CH5 STK834166 3-methyl-7-(3-methylbenzyl)-8-((2-oxopropyl)thio)-1H-purine-2,6(3H,7H)-dione\; 303973-50-4; 3-methyl-7-(3-methylbenzyl)-8-((2-oxopropyl)thio)-1H-purine-2,6(3H,7H)-dione; 3-methyl-7-(3-methylbenzyl)-8-[(2-oxopropyl)sulfanyl]-3,7-dihydro-1H-purine-2,6-dione; CHEMBL5176477; STK834166; 3-methyl-7-[(3-methylphenyl)methyl]-8-(2-oxopropylsulfanyl)purine-2,6-dione; AKOS000717705; ST080090; AB00667614-01; AG-690/12244900; SR-01000370716; SR-01000370716-1; F0372-0486; Z223843884; 3-methyl-7-[(3-methylphenyl)methyl]-8-(2-oxopropylthio)-1,3,7-trihydropurine-2 ,6-dione; 3-methyl-7-[(3-methylphenyl)methyl]-8-[(2-oxopropyl)sulfanyl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione CC(=O)CSc1nc2c(c(=O)[nH]c(=O)n2C)n1Cc1cccc(C)c1 Stabilizer C17H18N4O3S 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-QGHBST CHEMBL5199006 (4-chlorophenyl)-[3-[(5-naphthalen-1-yltetrazol-2-yl)methyl]-5-sulfanylidene-1H-1,2,4-triazol-4-yl]methanone\; CHEMBL5199006 O=C(c1ccc(Cl)cc1)n1c(Cn2nnc(-c3cccc4ccccc34)n2)n[nH]c1=S Stabilizer C21H14ClN7OS 14-3-3γ;SLP76 P61981/Q13094 . 10.1039/d1md00172h TPD-Y64RD5 HY-132199 SJ6986; 2765625-93-0; N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide; CHEMBL5094191; SCHEMBL24642791; BDBM669519; EX-A5128; NSC829444; AKOS040758546; US20240132463, Compound 1; AT39036; NSC-829444; SJ6986?; BP-40592; MS-29230; N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide; HY-132199; CS-0173224; N-(2-(2,6-dioxopiperidin-3-yl)-1,3- dioxoisoindolin-5-yl)-2- (trifluoromethoxy)benzenesulfonamide C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NS(=O)(=O)C4=CC=CC=C4OC(F)(F)F Degrader C20H14F3N3O7S GSPT1;GSPT2 P15170/Q8IYD1 CRBN 10.1182/blood.2022017813 TPD-Q78N47 PMID37252362_2 . CSCCNC(=O)[C@H]1CCCN(C(=O)c2cc(Cl)c(O)c(Cl)c2)C1 Stabilizer C16H20Cl2N2O3S 14-3-3σ;FOXO1 P31947/Q12778 . 10.1021/acscentsci.2c01449 TPD-N9LWHS PMID37252362_3 . CSCCNC(=O)[C@H]1CCCN(C(=O)c2cc(Cl)cc(Cl)c2N)C1 Stabilizer C16H21Cl2N3O2S 14-3-3σ;FOXO1 P31947/Q12778 . 10.1021/acscentsci.2c01449 TPD-Q62XLU PMID37252362_4 . CSCCNC(=O)[C@@H]1CCCN(C(=O)c2ccc3[nH]nnc3c2)C1 Stabilizer C16H21N5O2S 14-3-3σ;FOXO1 P31947/Q12778 . 10.1021/acscentsci.2c01449 TPD-954WHX PMID37252362_5 . COc1ccc2cc([C@@H](C)C(=O)N3CCC(C(=O)NCCSC)CC3)ccc2c1 Stabilizer C23H30N2O3S 14-3-3σ;CRAF P31947/P04049 . 10.1021/acscentsci.2c01449 TPD-8T5U6Y PMID37252362_6 . CSCCNC(=O)[C@H]1CCCN(C(=O)c2cccc(Oc3ccccc3)c2)C1 Stabilizer C22H26N2O3S 14-3-3σ;CRAF P31947/P04049 . 10.1021/acscentsci.2c01449 TPD-VPD13O 1-[3-(methylthio)propanoyl]-4-[3-(trifluoromethyl)phenyl]-4-piperidinol 1-[3-(Methylthio)propanoyl]-4-[3-(trifluoromethyl)phenyl]-4-piperidinol\; 1-[3-(methylthio)propanoyl]-4-[3-(trifluoromethyl)phenyl]-4-piperidinol CSCCC(=O)N1CCC(O)(c2cccc(C(F)(F)F)c2)CC1 Stabilizer C16H20F3NO2S 14-3-3σ;CRAF P31947/P04049 . 10.1021/acscentsci.2c01449 TPD-EUAJFT PMID37252362_8 . CSCCC(=O)N1CCC(O)(c2ccc(Cl)c(C(F)(F)F)c2)CC1 Stabilizer C16H19ClF3NO2S 14-3-3σ;CRAF P31947/P04049 . 10.1021/acscentsci.2c01449 TPD-AS3OHK 14-3-3|O/ER|A stabilizer-1 14-3-3; O/ER; A stabilizer-1; HY-156125; CS-0892616 CC1CC(Nc2ccc(Cl)cc2)(C(=O)N2CCC3(CCN(C(=O)CCl)CC3)CC2)CC(C)O1 Stabilizer C25H35Cl2N3O3 14-3-3σ;ERα P31947/P03372 . 10.1021/jacs.3c05161 TPD-ZGZ86Y Antascomicin B Antascomicin B; (1R,9S,12S,15S,16E,20E,23R,24S,27R)-1-Hydroxy-15,23,27-trimethyl-12-[(2R)-1-[(1S,2S,3S,4R)-2,3,4-trihydroxycyclohexyl]propan-2-yl]-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacosa-16,20-diene-2,3,10,22-tetrone; (1R,9S,12S,15S,16E,20E,23R,24S,27R)-1-hydroxy-15,23,27-trimethyl-12-((2R)-1-((1S,2S,3S,4R)-2,3,4-trihydroxycyclohexyl)propan-2-yl)-11,28-dioxa-4-azatricyclo(22.3.1.04,9)octacosa-16,20-diene-2,3,10,22-tetrone C[C@H]\1CC[C@H](OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]3([C@@H](CC[C@H](O3)[C@H](C(=O)/C=C/CC/C=C1)C)C)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H]([C@H]4O)O)O Stabilizer C37H57NO10 FKBP51;Akt1 Q13451/P31749 . 10.1016/j.bmcl.2024.129728 TPD-0HBIV4 XJF [(4aR,8aR)-2,3,4,5,6,7,8,8a-octahydro-1H-quinolin-4a-yl]methyl N-phenylcarbamate\; [(4aR,8aR)-2,3,4,5,6,7,8,8a-octahydro-1H-quinolin-4a-yl]methyl N-phenylcarbamate; XJF O=C(Nc1ccccc1)OC[C@@]12CCCC[C@H]1NCCC2 Stabilizer C17H24N2O2 14-3-3σ;14-3-3ζ;TAZ P31947/P63104/Q9GZV5 . 10.1021/acs.biochem.4c00248 TPD-AF17IW 4-(Methylsulfonyl)benzaldehyde 4-(methylsulfonyl)benzaldehyde; DTXSID00277593; DTXCID90228751; 674-175-2; 5398-77-6; 4-methylsulfonylbenzaldehyde; 4-methylsulphonyl benzaldehyde; 4-methanesulfonylbenzaldehyde; 4-methanesulfonyl-benzaldehyde; MFCD00216485; 4-methylsulfonyl-benzaldehyde; 4-(methylsulphonyl)benzaldehyde; 4-methylsulphonylbenzaldehyde; BENZALDEHYDE, 4-(METHYLSULFONYL)-; NSC3011; 4-Formylphenyl Methyl Sulfone; 4-Methanesulfonylbenzaldehyde; Methyl 4-Formylphenyl Sulfone; NSC 3011; p-(Methylsulfonyl)benzaldehyde; p-methylsulfonylbenzaldehyde; p-methylsulfonyl-benzaldehyde; 4-methylsulfonyl benzaldehyde; 4-methanesulfonyl benzaldehyde; SCHEMBL607349; SCHEMBL3123896; NSC-3011; LT0039; SBB005572; STK980611; AKOS005640659; AB04882; CS-W002526; PS-5995; BP-12660; PD193281; SY002002; 4-(Methylsulfonyl)benzaldehyde, AldrichCPR; DB-052422; ST50825216; EN300-51882; Z732216198 CS(=O)(=O)c1ccc(C=O)cc1 Stabilizer C8H8O3S 14-3-3σ;p65 P31947/Q04206 . 10.1002/anie.202008585 TPD-I8PEG3 0AW N-[(5-carbamimidoyl-3-phenylthiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-5-carboxamide\; 0AW N=C(N)c1cc(-c2ccccc2)c(CNC(=O)c2ccc3c(c2)CCO3)s1 Stabilizer C21H19N3O2S 14-3-3σ;ERα P31947/P03372 . 10.1002/cbic.202300636 TPD-YOP33B PLX-3618 N-[3-[4-[(9S)-9-(2-amino-2-oxoethyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-7-yl]phenyl]phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide\; PLX-3618; HY-161779; CS-1106743 CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)N)C4=CC=C(C=C4)C5=CC(=CC=C5)NC(=O)C6=C7N=CC=CN7N=C6)C Degrader C32H27N9O2S BRD4 O60885 DCAF11 10.1158/1535-7163.MCT-24-0219 TPD-4T271C 1-(7,8-Dichloro-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one 61563-45-9; 1-(7,8-Dichloro-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one; 1-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one; LZTR1-KRAS modulator 1; N-acetyl-7,8-dichloro-1,2,3,4-tetrahydroisoquinoline; SCHEMBL11190519; DTXSID40503782; PSQATYDOUXPBMP-UHFFFAOYSA-N; 1-(7,8-DICHLORO-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)ETHANONE; DB-406805; CS-0668542; 2-acetyl-7,8-dichloro-1,2,3,4-tetrahydroisoquinoline; Z1861995405; 1-(7,8-Dichloro-3,4-dihydro-2(1H)-isoquinolinyl)ethanone CC(=O)N1CCc2ccc(Cl)c(Cl)c2C1 Degrader C11H11Cl2NO KRAS P01116 LZTR1 10.1021/acschembio.4c00077 TPD-PJUBUW 2-(7,8-dichloro-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoacetic acid Z6466689386 O=C(O)C(=O)N1CCc2ccc(Cl)c(Cl)c2C1 Degrader C11H9Cl2NO3 KRAS P01116 LZTR1 10.1021/acschembio.4c00077 TPD-QUT28S PMID38738787_DP-005 . COC[C@H]1CC[C@@H]2/C1=C\[C@@]1(C)CCC(C(C)C)=C1[C@@H](OC1OC(CO)C(O)C(O)C1O)[C@H](O)[C@@H]2C Stabilizer C27H44O8 14-3-3σ;p65 P31947/Q04206 . 10.1002/cbic.202400214 TPD-ADFHCY Cotylenin A COTYLENIN A; O6G9S48JRX; UNII-O6G9S48JRX; NSC 319518; COTYLENIN-A; 12708-37-1; Dicyclopenta(a,d)cyclooctene-1,5-diol, 1,2,3,3a,4,5,6,8,9,9a-decahydro-1-(methoxymethyl)-4-methyl-7-(1-methylethyl)-6-(((2S,3S,4aS,5R,7S,8R,8aR)-tetrahydro-8-hydroxy-5-(methoxymethyl)-3-methyl-3-((2S)-oxiranyl)-7H-2,4a-epoxy-5H-pyrano(3,4-b)-1,4-dioxin-7-yl)oxy)-, (1R,3aS,4R,5R,6R,9aR)-; NSC-319518; .ALPHA.-D-XYLO-HEXOPYRANOSID-4-ULOSE, 1,2,4,5,6,6A,7,8,9,10A-DECAHYDRO-5,9-DIHYDROXY-9-(METHOXYMETHYL)-6,10A-DIMETHYL-3-(1-METHYLETHYL)DICYCLOPENTA(A,D)CYCLOOCTEN-4-YL 6-O-METHYL-, CYCLIC 2-HYDROXY-1-METHYL-1-OXIRANYL-1,2-ETHANEDIYL ACETAL, CYCLIC 3,42-ANHYDRIDE, (1(4R,5R,6R,6AS,9R,10AR),4R(1S(S),2S))-; Dicyclopenta[a,d]cyclooctene-1,5-diol, 1,2,3,3a,4,5,6,8,9,9a-decahydro-1-(methoxymethyl)-4-methyl-7-(1-methylethyl)-6-[[(2S,3S,4aS,5R,7S,8R,8aR)-tetrahydro-8-hydroxy-5-(methoxymethyl)-3-methyl-3-[(2S)-oxiranyl]-7H-2,4a-epoxy-5H-pyrano[3,4-b]-1,4-dioxin-7-yl]oxy]-, (1R,3aS,4R,5R,6R,9aR)-; ALPHA-D-XYLO-HEXOPYRANOSID-4-ULOSE, 1,2,4,5,6,6A,7,8,9,10A-DECAHYDRO-5,9-DIHYDROXY-9-(METHOXYMETHYL)-6,10A-DIMETHYL-3-(1-METHYLETHYL)DICYCLOPENTA(A,D)CYCLOOCTEN-4-YL 6-O-METHYL-, CYCLIC 2-HYDROXY-1-METHYL-1-OXIRANYL-1,2-ETHANEDIYL ACETAL, CYCLIC 3,42-ANHYDRIDE, (1(4R,5R,6R,6AS,9R,10AR),4R(1S(S),2S))-; NSC319518; (1R,2E,4R,7S,8R,9R,10R)-10-[[(1R,4S,9S)-5-Hydroxy-2-(methoxymethyl)-9-methyl-9-(oxiran-2-yl)-3,7,10,11-tetraoxatricyclo[6.2.1.01,6]undecan-4-yl]oxy]-4-(methoxymethyl)-1,8-dimethyl-12-propan-2-yltricyclo[9.3.0.03,7]tetradeca-2,11-diene-4,9-diol C[C@@H]1[C@@H]\2CC[C@@](/C2=C/[C@]3(CCC(=C3[C@H]([C@@H]1O)O[C@@H]4C(C5[C@@]6(C(O4)COC)OC(O5)[C@](O6)(C)C7CO7)O)C(C)C)C)(COC)O Stabilizer C33H50O11 14-3-3ζ;CRAF P63104/P04049 . 10.1002/cbic.202400214 TPD-U6BPLH RZT 4-azanyl-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide\; 4-azanyl-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide; RZT N=C(N)c1cc(-c2cccc(NC(=O)C3(Oc4ccc(Cl)cc4)CCC(N)CC3)c2)cs1 Stabilizer C24H25ClN4O2S 14-3-3σ;ERα P31947/P03372 . 10.1002/anie.202308004 TPD-RDPC1D NSC-13728 4-Methyl-6-((4-methyl-2-(1-piperidinyl)-6-quinolinyl)methyl)-2-(1-piperidinyl)quinoline\; NSC13728; NSC-13728; NCGC00013165; NCIStruc1_000367; NCIStruc2_001002; CHEMBL1337951; SCHEMBL18134596; NCI13728; CCG-37828; NCGC00013165-02; NCGC00096286-01; NCI60_000845; 4-methyl-6-((4-methyl-2-(1-piperidinyl)-6-quinolinyl)methyl)-2-(1-piperidinyl)quinoline; 4-methyl-6-[[4-methyl-2-(1-piperidyl)-6-quinolyl]methyl]-2-(1-piperidyl)quinoline CC1=CC(=NC2=C1C=C(C=C2)CC3=CC4=C(C=C3)N=C(C=C4C)N5CCCCC5)N6CCCCC6 Stabilizer C31H36N4 Max P61244 . 10.1016/j.bcp.2020.113821 TPD-W857PU KI-MS2-008 (3aS,10bS)-5-[2-(benzenesulfonyl)ethyl]-3a-benzyl-2-phenyl-6,10b-dihydro-[1,3]oxazolo[4,5-d][2]benzazepin-4-one\; KI-MS2-008; CHEMBL4449950; SCHEMBL19239785; GLXC-20865; (+/-)-(3aS*,10bS*)-3a-Benzyl-2-phenyl-5-(2-(phenylsulfonyl)ethyl)-3a,5,6,10b-tetrahydro-4H-benzo[c]oxazolo[5,4-e]azepin-4-one; 2125730-80-3 C1C2=CC=CC=C2[C@H]3[C@@](C(=O)N1CCS(=O)(=O)C4=CC=CC=C4)(N=C(O3)C5=CC=CC=C5)CC6=CC=CC=C6 Stabilizer C32H28N2O4S Max P61244 . 10.1016/j.chembiol.2019.02.009 TPD-TSH3L0 NDB N-Benzyl-N-(3-Tert-Butyl-4-Hydroxyphenyl)-2,6-Dichloro-4-(Dimethylamino)benzamide\; NDB; 1660153-08-1; CHEMBL5278485; N-Benzyl-N-(3-Tert-Butyl-4-Hydroxyphenyl)-2,6-Dichloro-4-(Dimethylamino)benzamide; SCHEMBL24212429; KRC15308; NDB, >=98% (HPLC); BDBM50612390; MS-28715; HY-138937; CS-0173441; Q27467650; XX9 CC(C)(C)C1=C(C=CC(=C1)N(CC2=CC=CC=C2)C(=O)C3=C(C=C(C=C3Cl)N(C)C)Cl)O Stabilizer C26H28Cl2N2O2 FXRα Q96RI1 . 10.1074/jbc.M114.630475 TPD-J9DXH7 PD193842 N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-3-fluoro-N-methylbenzamide\; PD193842 CN(C)CCSSCCN(C)C(=O)c1cccc(F)c1 Stabilizer C14H21FN2OS2 14-3-3σ;ERRγ P31947/P62508 . 10.1021/acschembio.0c00646 TPD-4CJIJV PMID33196173_2 . CN(C)CCSSCCNC(=O)c1cccc(F)c1 Stabilizer C13H19FN2OS2 14-3-3σ;ERRγ P31947/P62508 . 10.1021/acschembio.0c00646 TPD-4GFCLG PD195360 N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-4-fluoro-N-methylbenzamide\; PD195360 CN(C)CCSSCCN(C)C(=O)c1ccc(F)cc1 Stabilizer C14H21FN2OS2 14-3-3σ;ERRγ P31947/P62508 . 10.1021/acschembio.0c00646 TPD-WSDIRQ N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-N-methylbenzamide PD195314 CN(C)CCSSCCN(C)C(=O)c1ccccc1 Stabilizer C14H22N2OS2 14-3-3σ;ERRγ P31947/P62508 . 10.1021/acschembio.0c00646 TPD-E9FOXE PD194529 3-bromo-N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-N-methylbenzamide\; PD194529 CN(C)CCSSCCN(C)C(=O)c1cccc(Br)c1 Stabilizer C14H21BrN2OS2 14-3-3σ;ERRγ P31947/P62508 . 10.1021/acschembio.0c00646 TPD-01FOIB PMID33196173_6 . CN(C)CCSSCCN(C)C(=O)c1cccc(C(F)(F)F)c1 Stabilizer C15H21F3N2OS2 14-3-3σ;ERRγ P31947/P62508 . 10.1021/acschembio.0c00646 TPD-HC4Q10 N-(1-azabicyclo[2.2.2]octan-3-yl)-1-azabicyclo[2.2.2]octan-3-amine diquinuclidin-3-ylamine; AKOS009246330; ST45001006 C1CN2CCC1C(NC1CN3CCC1CC3)C2 Stabilizer C14H25N3 14-3-3η Q04917 . 10.1002/cbic.202200178 TPD-WG1VCU SCHEMBL23903318 2-(4-chlorophenoxy)-N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-N,2-dimethylpropanamide\; SCHEMBL23903318; PD194494 CN(C)CCSSCCN(C)C(=O)C(C)(C)Oc1ccc(Cl)cc1 Stabilizer C17H27ClN2O2S2 14-3-3σ;ERα P31947/P03372 . 10.1021/jacs.8b11658 TPD-DOUHJ1 SCHEMBL23903315 2-(4-chlorophenoxy)-N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-2-methylpropanamide\; SCHEMBL23903315; PD194487 CN(C)CCSSCCNC(=O)C(C)(C)Oc1ccc(Cl)cc1 Stabilizer C16H25ClN2O2S2 14-3-3σ;ERα P31947/P03372 . 10.1021/jacs.8b11658 TPD-AMVM8O BMS-8 1-[[3-Bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylicacid\; BMS-8; 1675201-90-7; 1-[[3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylicacid; CHEMBL4099869; 1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid; 1-[3-Bromo-4-(2-methyl-biphenyl-3-ylmethoxy)-benzyl]-piperidine-2-carboxylic acid; 1-[[3-bromo-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid; BMS-8?; SCHEMBL16554898; US9872852, Example 8; ASC20190; BDBM50239943; AKOS040748016; DA-51250; MS-29173; HY-116274; CS-0064596; E85679 CC1=C(C=CC=C1C2=CC=CC=C2)COC3=C(C=C(C=C3)CN4CCCCC4C(=O)O)Br Stabilizer C27H28BrNO3 PD-L1 Q9NZQ7 . 10.3389/fchem.2019.00764 TPD-UWMQE3 BMS-1166 (2R,4R)-1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid\; BMS-1166; 1818314-88-3; (2R,4R)-1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid; (2R,4R)-1-(5-Chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid; CHEMBL4071326; GTPL9608; PD-1/PD-L1-IN-1; SCHEMBL17161416; GLXC-20285; EX-A3096; TXC31488; BDBM50239948; NSC830202; s8859; ZB1577; US9850225, Example 1166; AKOS040758788; NSC-830202; compound 2c [PMID: 28613862]; AC-36328; DA-51239; MS-30917; HY-102011; CS-0022454; BMS-1166 (PD-1/PD-L1-IN1)?; Example 1166 [WO2015160641A2]; G16471 CC1=C(C=CC=C1C2=CC3=C(C=C2)OCCO3)COC4=C(C=C(C(=C4)OCC5=CC(=CC=C5)C#N)CN6C[C@@H](C[C@@H]6C(=O)O)O)Cl Stabilizer C36H33ClN2O7 PD-L1 Q9NZQ7 . 10.3389/fchem.2019.00764 TPD-2BCDJ2 CHEMBL4640360 [2-[[(E)-(2,3-dichlorophenyl)methylideneamino]carbamoyl]phenyl]phosphonic acid\; CHEMBL4640360; BDBM50540834 O=C(N/N=C/c1cccc(Cl)c1Cl)c1ccccc1P(=O)(O)O Stabilizer C14H11Cl2N2O4P 14-3-3ζ;synaptopodin P63104/Q8N3V7 . 10.1021/acsmedchemlett.9b00541 TPD-9K946R CHEMBL4634488 N-[(E)-(3-bromophenyl)methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide\; CHEMBL4634488; BDBM50540835 O=C(N/N=C/c1cccc(Br)c1)c1cc2c(s1)CCCC2 Stabilizer C16H15BrN2OS 14-3-3ζ;synaptopodin P63104/Q8N3V7 . 10.1021/acsmedchemlett.9b00541 TPD-MJSFOH CHEMBL4643097 N-[(E)-(2,3-dichlorophenyl)methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide\; CHEMBL4643097; BDBM50540836 O=C(N/N=C/c1cccc(Cl)c1Cl)c1cc2c(s1)CCCC2 Stabilizer C16H14Cl2N2OS 14-3-3ζ;synaptopodin P63104/Q8N3V7 . 10.1021/acsmedchemlett.9b00541 TPD-G5DV19 29207575_22b . CC(=O)N1CCN(Cc2ccc(Br)cc2C(=O)c2cc(O)c(O)cc2Br)CC1 Stabilizer C20H20Br2N2O4 Keap1;Nrf2 Q14145/Q16236 . 10.3390/molecules22122142 TPD-87TGUD STK631094 [2-[2-Oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid\; [2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid; OQE; STK631094; AKOS005563455; (2-{2-oxo-2-[(2-phenylethyl)amino]ethoxy}phenyl)phosphonic acid O=C(COc1ccccc1P(=O)(O)O)NCCc1ccccc1 Stabilizer C16H18NO5P 14-3-3β;ChREBP P31946/Q9NP71 . 10.1038/s41467-020-17741-0 TPD-KJ3470 PMID32770072_26 [2-[2-[2-(4-Fluorophenyl)ethylamino]-2-oxoethoxy]phenyl]phosphonic acid O=C(COc1ccccc1P(=O)(O)O)NCCc1ccc(F)cc1 Stabilizer C16H17FNO5P 14-3-3β;ChREBP P31946/Q9NP71 . 10.1038/s41467-020-17741-0 TPD-UMP01K PMID32770072_30 [2-[2-Oxo-2-[2-(2-phenylmethoxyphenyl)ethylamino]ethoxy]phenyl]phosphonic acid O=C(COc1ccccc1P(=O)(O)O)NCCc1ccccc1OCc1ccccc1 Stabilizer C23H24NO6P 14-3-3β;ChREBP P31946/Q9NP71 . 10.1038/s41467-020-17741-0 TPD-4XYRRV BMS-37 N-[2-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methylamino]ethyl]acetamide\; BMS-37; 1675202-20-6; CHEMBL4081869; SCHEMBL16554806; US9872852, Example 37; GLXC-21700; EX-A7926; BDBM50239942; NSC820853; NSC-820853; DA-71581; HY-150879; CS-0564751; H39858; 8J8; N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CNCCNC(=O)C)OC Stabilizer C27H32N2O4 PD-L1 Q9NZQ7 . 10.3390/ijms24021280 TPD-SRSU33 BMS-200 (S)-4-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2,5-difluorobenzyl)amino)-3-hydroxybutanoic acid\; CHEMBL4062686; BMS-200; 1675203-82-3; (S)-4-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2,5-difluorobenzyl)amino)-3-hydroxybutanoic acid; SCHEMBL16555050; GLXC-20321; US9872852, Example 200; BDBM50239945; HY-120402; (3S)-4-[[4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-2,5-difluorophenyl]methylamino]-3-hydroxybutanoic acid CC1=C(C=CC=C1C2=CC3=C(C=C2)OCCO3)COC4=C(C=C(C(=C4)F)CNC[C@H](CC(=O)O)O)F Stabilizer C27H27F2NO6 PD-L1 Q9NZQ7 . 10.3390/ijms24021280 TPD-TCA2AY BMS-1001 (2~{R})-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-methyl-phenyl]methylamino]-3-oxidanyl-propanoic acid\; BMS-1001; 2113650-03-4; (2~{R})-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-methyl-phenyl]methylamino]-3-oxidanyl-propanoic acid; (2R)-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-5-methylphenyl]methylamino]-3-hydroxypropanoic acid; (2-((3-Cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine; CHEMBL4084368; SCHEMBL23258931; EX-A3527; NJD65003; BMS-1001?; s9610; AKOS040759411; AC-36475; TS-09809; HY-120647; CS-0078526 CC1=CC(=C(C=C1OCC2=C(C(=CC=C2)C3=CC4=C(C=C3)OCCO4)C)OCC5=CC(=CC=C5)C#N)CN[C@H](CO)C(=O)O Stabilizer C35H34N2O7 PD-L1 Q9NZQ7 . 10.3390/ijms24021280 TPD-PJ9SR7 23601647_FC-THF . COC[C@H]1CC[C@@H]2/C1=C\[C@]1(C)C(=C(C(C)C)[C@@H]3CCO[C@@H]31)[C@@H](O[C@H]1O[C@@H]3COC(C)(C)OC3C(O)C1O)[C@H](O)[C@@H]2C Stabilizer C32H50O9 14-3-3σ;TASK-3 P31947/Q9NPC2 . 10.1016/j.chembiol.2013.03.015 TPD-ICBPJY IBE667 4-(3-{4-[(3-Aminopropyl)carbamoyl]phenyl}-1h-Indazol-1-Yl)-N-Methylbenzamide\; 4-(3-{4-[(3-Aminopropyl)carbamoyl]phenyl}-1h-Indazol-1-Yl)-N-Methylbenzamide; IBE667; IBE-667; GLXC-15083; Q27452088; N-(3-aminopropyl)-4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzamide; 1HV CNC(=O)C1=CC=C(C=C1)N2C3=CC=CC=C3C(=N2)C4=CC=C(C=C4)C(=O)NCCCN Stabilizer C25H25N5O2 LFA-1;ICAM-1 P20701/P05362 . 10.1002/anie.201310240 TPD-RPBZ5Q PD194610 2-(4-bromophenoxy)-N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-2-methylpropanamide\; PD194610 CN(C)CCSSCCNC(=O)C(C)(C)Oc1ccc(Br)cc1 Stabilizer C16H25BrN2O2S2 14-3-3σ;ERα P31947/P03372 . 10.1021/acsmedchemlett.1c00088 TPD-D5B3MA PMID34136078_7 . CN(C)CCSSCCNC(=O)C(C)(C)Oc1ccc(F)cc1 Stabilizer C16H25FN2O2S2 14-3-3σ;ERα P31947/P03372 . 10.1021/acsmedchemlett.1c00088 TPD-XEL579 PD194613 2-(3,5-difluorophenoxy)-N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-2-methylpropanamide\; PD194613 CN(C)CCSSCCNC(=O)C(C)(C)Oc1cc(F)cc(F)c1 Stabilizer C16H24F2N2O2S2 14-3-3σ;ERα P31947/P03372 . 10.1021/acsmedchemlett.1c00088 TPD-YDAQS8 PD194611 2-(3,5-dichlorophenoxy)-N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-2-methylpropanamide\; PD194611 CN(C)CCSSCCNC(=O)C(C)(C)Oc1cc(Cl)cc(Cl)c1 Stabilizer C16H24Cl2N2O2S2 14-3-3σ;ERα P31947/P03372 . 10.1021/acsmedchemlett.1c00088 TPD-QLCMM7 SCHEMBL23884821 N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-2-methyl-2-phenoxypropanamide\; SCHEMBL23884821; PD194609 CN(C)CCSSCCNC(=O)C(C)(C)Oc1ccccc1 Stabilizer C16H26N2O2S2 14-3-3σ;ERα P31947/P03372 . 10.1021/acsmedchemlett.1c00088 TPD-R6R3XV SCHEMBL25442323 N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-2-methyl-2-(4-methylphenoxy)propanamide\; SCHEMBL25442323 Cc1ccc(OC(C)(C)C(=O)NCCSSCCN(C)C)cc1 Stabilizer C17H28N2O2S2 14-3-3σ;ERα P31947/P03372 . 10.1021/acsmedchemlett.1c00088 TPD-Q961B5 PD194612 2-(4-bromo-3-methoxyphenoxy)-N-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-2-methylpropanamide\; PD194612 COc1cc(OC(C)(C)C(=O)NCCSSCCN(C)C)ccc1Br Stabilizer C17H27BrN2O3S2 14-3-3σ;ERα P31947/P03372 . 10.1021/acsmedchemlett.1c00088 TPD-2V51GW 14-3-3σ;ER&α 10.1021/acsmedchemlett.1c00088 Stabilizer P31947/P03372 . PMID34136078_13 . CN(C)CCSSCCNC(=O)C(C)(C)Oc1ccc([N+](=O)[O-])cc1Cl C16H24ClN3O4S2 TPD-IH1R0J BI-2852 (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one\; BI-2852; 2375482-51-0; CHEMBL4750445; (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one; (S)-5-Hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl)-1H-indol-3-yl)isoindolin-1-one; (3S)-5-hydroxy-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1H-indol-3-yl]-2,3-dihydroisoindol-1-one; F0K; SCHEMBL24414712; GLXC-15818; BCP31539; EX-A4793; BDBM50549225; BI2852; NSC853556; AKOS040732592; BI2852;BI 2852; NSC-853556; MS-29593; HY-126247; CS-0100975; G16897; (3S)-2,3-dihydro-5-hydroxy-3-[2-[[[[1-[(1-methyl-1H-imidazol-4-yl)methyl]-1H-ind ol-6-yl]methyl]amino]methyl]-1H-indol-3-yl]-1H-Isoindol-1-one CN1C=C(N=C1)CN2C=CC3=C2C=C(C=C3)CNCC4=C(C5=CC=CC=C5N4)[C@@H]6C7=C(C=CC(=C7)O)C(=O)N6 Stabilizer C31H28N6O2 KRAS P01116 . 10.1039/d1sc03484g TPD-N62V45 4-(2,6-Dimethylmorpholin-4-yl)sulfonylbenzaldehyde SCHEMBL23884687; PD194190 CC1CN(S(=O)(=O)c2ccc(C=O)cc2)CC(C)O1 Stabilizer C13H17NO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-APWKG9 4-(3,4-dihydro-2H-quinoxalin-1-ylsulfonyl)benzaldehyde SCHEMBL23884701; PD194650 O=Cc1ccc(S(=O)(=O)N2CCNc3ccccc32)cc1 Stabilizer C15H14N2O3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-XF6104 Capsaicin Capsaicin; 404-86-4; CAPSAICINE; Qutenza; trans-Capsaicin; Styptysat; Isodecenoic acid vanillylamide; Ausanil; Mioton; FEMA No. 3404; Dolenon; Ovocap; Capzasin-hp; Caswell No. 158; Togarashi orenji; ALGRX 4975; Ratden pe 40; NCI-C56564; NSC 56353; Capsaicina; CCRIS 1588; CHEBI:3374; HSDB 954; (e)-n-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide; Zostrix HP; NGX-1998; EINECS 206-969-8; UNII-S07O44R1ZM; NSC-56353; (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide; EPA Pesticide Chemical Code 070701; N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-trans-6-enamide; BRN 2816484; S07O44R1ZM; DTXSID9020241; NSC56353; DTXCID30241; Capsaicin (USP:INN); Capsaicin [USP:INN]; CAPSAICIN (MART.); CAPSAICIN [MART.]; CAPSAICIN (USP-RS); CAPSAICIN [USP-RS]; CAPSAICIN (USP MONOGRAPH); CAPSAICIN [USP MONOGRAPH]; Zacin; Capsaicin Patch; capsaicinum; Capsacin; Capsimide; Neuriterx; Neuritrx; Awaye; BioMega; Ageranium Patch; Capsaicin Cream; Capsaicin Heat; Castiva Warming; Guardania Pain; Medicated Heat; Rugby Capsaicin; Satogesic Hot; MediRelief Hot; SprayPain Away; Pure Relief; CVS Capsaicin; Painazin CP; Bio-Sorb; Capsaicin Extract; NobleAid CapsAid; Melt Pain Away; Red Hot; PainBloc24; Nufabrx Back Wrap; Nufabrx Neck Wrap; Gellert Joint Care; Nufabrx Arm Sleeve; Omega 3; CVS Roll-On; Nufabrx Calf Sleeve; Nufabrx Knee Sleeve; Capsaicin 0.15; Capsaisin 0.1%; LivReliefPain Relief; CAPSAISIN; CAPZIX; Nufabrx Ankle Sleeve; Nufabrx Wrist Sleeve; REZIL; FlexxSonicPain Relief; Hot SpotPoint Relief; Capsaicin 0.05%; Capsaicin 0.15%; Capsaicin 0.25%; Capsaicin Pain Relief; Rugby Capsaicin Cream; capsaicin 0.075%; LEADER CAPSAICIN; MEIJER CAPSAICIN; A2A ARTHRITIS; Coralite Medicated Heat; HOT PAIN RELIEF; RETADOLORPain Relief; Sure Relief SR Relief; Sure Result SR Relief; Walgreens Capsaicin Hot; Campo pharma Muscle hot; Capsaicin 0.1 Percent; EQUI-BLOCKORIGINAL; Nufabrx Lower Leg Sleeve; Zostrix Original Strength; CapsaicinTopical Analgesic; QC Arthritis Pain Relief; SCREAMIN HOT TOAST; Wellness Products VictoRx; CapsaicinExternal Analgesic; Medicated Compression Sock; Nufabrx Foot/Ankle Sleeve; Nufabrx Hand/Wrist Sleeve; Wellness Products J-FLEX; CVS Medicated Heat 1 ct; SINSINPAS HOT LARGE; 2-Count HEAT PATCHES; Capsaicin 0.075 Percent; EQUI-BLOCKDT FORMULA; CANNAVERA PAIN RELIEF; CAPSAICIN HOT PATCHES; EARTHS CARE ARTHRITIS; Revlex Arthritis Pain Relief; Solstice Capsaicin Patch Hot; CareALL Arthritis and Muscle; RITE AID CAPSICUM HOT; ASTRAPHARM CHILLI BRAND; WellPatch Warming Pain Relief; BRONSON SOOTHE Pain Relief; FYZICAL SPORTS Pain Relief; Nufabrx Medicine Infused Socks; Rugby Arthritis Pain Relieving; Nufabrx Lower Leg Sleeve M/L; Equate Capsaicin Pain Relieving; HURT BLOCKER PROPain Relief; Nufabrx Lower Leg Sleeve XS/S; Good Neighbor Pharmacy Capsaicin; Better Nature Pain Relief BalmX; Fast Arthritis AidPain Relieving; Rugby CapsaicinExternal Analgesic; Sherman and Clark Pain Relieving; Family Care Arthritis Pain Relief; Nufabrx Lower Leg Sleeve XL/XXL; Capsaicin 0.025% Topical Patch; Capzasin HP Arthritis Pain Relief; Penetrex(r) Arthritis Pain Relief; Pure ReliefPenetrating Pain Relief; Capsaicin HP Arthritis Pain Relief; Frankie Avalons Zero Pain Roll On; Leader Capsaicin Pain Relief Cream; beeRX Muscle and Joint Pain Relief; CVS Capsaicin arthritis pain relief; DCH Arthritis Pain Relief Roll-On; Miracle Plus OvernightPain Relieving; Toplast Hot Capsaicin 0.025percent; Nufabrx Medicine Infused Ankle Sleeve; AVON HeXashield Arthritis Pain Relief; Zostrix High Potency Foot Pain Relief; (6E)-N-; FYZICAL SPORTS Pain Relief 2 MILD; Dr. Harveys Herbal Motion Pain Formula; CAPSAICIN HEAT PATCHES PAIN RELIEF; CAPSAICIN (CONSTITUENT OF CAPSICUM); Dusel Warm Arthritis Dead Sea Salt Therapy; Good Neighbor Capsaicin Heat Patch for Back; Rugby Arthritis Pain RelievingTopical Analgesic; ASTRAPHARM CHILLI BRAND EXTERNAL MEDICATED; CAPSAICIN HEAT PATCHES BACK AND LARGE AREAS; AVON HeXashield Arthritis Pain ReliefCream Capsaisin; Hempvana Ultra Strength Pain Relief Cream-Deep Heat; Walgreens Arthritis Pain Relief Capsaicin Analgesic; Flavor and Extract Manufacturers' Association No. 3404; 206-969-8; usepa/opp pesticide code: 070701; (E)-Capsaicin; Zostrix; Axsain; E-CAPSAICIN; NGX-4010; trans-8-Methyl-N-vanillyl-6-nonenamide; (E)-8-Methyl-N-vanillyl-6-nonenamide; MFCD00017259; Capsaicinoid; Transacin; 8-Methyl-N-vanillyl-trans-6-nonenamide; (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; Capsaicin (JAN/USP); 6-Nonenamide, 8-methyl-N-vanillyl-, (E)-; ZOSTRIX (TN); Cntx-4975; (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; (E)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE; 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6E)-; 1217899-52-9; ALGRX-4975; CHEMBL294199; 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-; Capsaicin [in oleoresin of capsicum]; N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide; 7553-53-9; NCGC00017337-02; 8-Methyl-N-vanillyl-(trans)-6-nonenamide; Capsaicin(E/Z-Mixture); (E)-N-((4-Hydroxy-3-methoxyphenyl)-methyl)-8-methyl-6-nonenamide; (E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide; 6-Nonenamide, (E)-N-((4-hydroxy-3-methoxy-phenyl)methyl)-8-methyl; 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (E)-; Capsaicin [USAN]; Capsicine; trans-Capsaicin-d3; Capsaicin (in oleoresin of capsicum); (6E)-N-{[4-hydroxy-3-(methyloxy)phenyl]methyl}-8-methylnon-6-enamide; 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (6E)-; NGX 4010; CAPSAICIN, NATURAL; 8-Methyl-N-Vanillyl-6-Nonenamide; SR-05000001861; neurotoxic; Isodecenoate; Zucapsaicin;Civamide;cis-Capsaicin; N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide; Adlea; 8-Methyl-N-vanillyl-6-nonenamide, (E)-; TNP00277; (E)-N-[(4-Hydroxy-3-methoxyphenyl)-methyl]-8-methyl-6-nonenamide; epsilon-capsaicin; 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6Z)-; capsacin(E); Qutenza;Vanilloid; 4DY; CAS-404-86-4; Prestwick_204; Capsaicin (Natural); Capsaicin - Natural; depletes Substance P; Capsaicin (Standard); starbld0019180; CAPSAICIN [INN]; CAPSAICIN [JAN]; CAPSAICIN [MI]; 6-Nonenamide, (E)-; CAPSAICIN [HSDB]; Prestwick2_000879; Prestwick3_000879; Spectrum5_000538; CAPSAICIN [VANDF]; N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide, (E)-; UPCMLD-DP092; CAPSAICIN [WHO-DD]; SCHEMBL8085; MR3H3; BSPBio_000957; BSPBio_001548; BSPBio_002917; CAPSAICIN [EMA EPAR]; MLS002154049; N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide; Capsaicin from Capsicum annuum; Capsaicin, analytical standard; SPECTRUM1501128; 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-; BPBio1_001053; GTPL2486; MEGxp0_001448; CAPSAICIN [ORANGE BOOK]; UPCMLD-DP092:001; UPCMLD-DP092:002; BDBM20461; BDBM86537; CHEBI:94524; HMS501B16; MSK8001D3; MSK8001; HMS1361N10; HMS1570P19; HMS1791N10; HMS1921H11; HMS1989N10; HMS2089N11; HMS2092D21; HMS2097P19; HMS2230O23; HMS3402N10; HMS3414F11; HMS3649N15; HMS3678F11; HMS5080D13; Pharmakon1600-01501128; 8-Methyl-N-vanillyl-6E-nonenamide; NGX-3781; NGX-7325; NSC_2548; Tox21_110817; Tox21_200315; BBL027836; CCG-39657; CCG-39908; EI-125; HB1179; HY-10448A; HY-10448R; LMFA08020085; NSC757844; s1990; STL372889; (E)8-methyl-N-vanillyl-6-Nonenamide; AKOS007930159; CS-1518; DB06774; FC19672; KS-5181; NSC-757844; SDCCGMLS-0066678.P001; TQ-1018; Capsaicin 10 microg/mL in Acetonitrile; Capsaicin, >=95%, from Capsicum sp.; IDI1_000354; IDI1_034018; SMP2_000337; NCGC00017337-03; NCGC00017337-04; NCGC00017337-05; NCGC00017337-06; NCGC00017337-07; NCGC00017337-08; NCGC00017337-09; NCGC00017337-10; NCGC00017337-11; NCGC00017337-12; NCGC00017337-13; NCGC00017337-17; NCGC00017337-18; NCGC00090853-01; NCGC00090853-02; NCGC00090853-03; NCGC00090853-04; NCGC00090853-06; NCGC00090853-07; NCGC00090853-08; NCGC00090853-09; NCGC00090853-10; NCGC00090853-11; NCGC00090853-12; NCGC00257869-01; USEPA/OPP Pesticide Code: 070701; AC-10114; AC-38165; CAS_404-86-4; HY-10448; LS-14673; SMR000718774; ST057183; XC180968; SBI-0052593.P002; CS-0181240; M1149; NS00004284; (E)-8-Methyl-N-vanillyl-6-nonenamide(8cl); C06866; D00250; AB00053098-11; AB00053098_12; Capsaicin, from Capsicum sp., >=50% (HPLC); EN300-7544118; 826 - Capsaicin and heat units in chilli powder; CAPSAICIN (CONSTITUENT OF CAPSICUM) [DSC]; N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide; Q273169; SR-05000001861-1; SR-05000001861-4; SR-05000001861-5; SR-05000001861-6; SR-05000001861-9; BRD-K37056290-001-01-1; BRD-K50590187-001-06-6; BRD-K50590187-001-19-9; BRD-K50590187-001-20-7; Capsaicin, certified reference material, TraceCERT(R); Capsaicin, European Pharmacopoeia (EP) Reference Standard; (6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide #; Capsaicin, United States Pharmacopeia (USP) Reference Standard; Capsaicin; 8-Methyl-N-vanillyl-trans-6-nonenamide; NGX-4010; N-[(4-hydroxy-3-methoxyphenyl)methyl]-6E-8-methyl-nonenamide; N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYL-6-NONENAMIDE [FHFI]; trans-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide; Capsaicin, Pharmaceutical Secondary Standard; Certified Reference Material; (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide;(E)-8-Methyl-N-vanillyl-6-nonenamide COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O Stabilizer C18H27NO3 PD-L1 Q9NZQ7 . 10.3390/ijms24021413 TPD-3HKCVG Zucapsaicin Zucapsaicin; 25775-90-0; cis-Capsaicin; Civamide; (Z)-Capsaicin; Civanex; Zucapsaicin [USAN:INN]; Zucapsaicina; Zucapsaicine; (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; Zuacta; BRN 4261852; ZUCAPSAICIN [INN]; ZUCAPSAICIN [USAN]; 15OX67P384; ZUCAPSAICIN [WHO-DD]; 6-Noneamide, 8-methyl-N-vanillyl-, (Z)-; DTXSID101014453; N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide (Z)-; 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (Z)-; 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (Z)-; zucapsaicinum; (Z)-N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methylnon-6-enamide; DTXCID90911474; M02AB02; 6-Noneamide, 8-methyl-N-vanillyl-, (Z)-(8CI); (Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide; (Z)-8-Methyl-N-vanillyl-6-nonenamide; (6Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; MFCD00209942; SMR000449294; 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6Z)-; SR-01000597644; TNP00277; UNII-15OX67P384; CAS-404-86-4; Tocris-0462; Tocris-0463; CPD000449294; Zucapsaicin (USAN/INN); (Z)-Capsaicin (Standard); SCHEMBL41210; MLS000758306; MLS001423959; CHEMBL313971; GTPL11576; HY-B1583R; CHEBI:135952; YKPUWZUDDOIDPM-VURMDHGXSA-N; GLXC-02505; HMS2051O07; HMS2235O20; HMS5085O18; HY-B1583; BDBM50519720; s6409; AKOS015851907; CCG-100774; DB09120; FC19671; NC00024; NG-0020; NCGC00016441-01; NCGC00016441-02; NCGC00016441-03; NCGC00017337-01; NCGC00024601-01; NCGC00024601-02; AC-31789; CS-0013480; NS00069888; D06388; EN300-7406722; Q8074969; SR-01000597644-1; SR-01000597644-2; (6Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide;(Z)-8-Methyl-N-vanillyl-6-nonenamide CC(C)/C=C\CCCCC(=O)NCC1=CC(=C(C=C1)O)OC Stabilizer C18H27NO3 PD-L1 Q9NZQ7 . 10.3390/ijms24021413 TPD-F9BW6K Curcumin curcumin; 458-37-7; Diferuloylmethane; Natural yellow 3; Kacha haldi; Indian saffron; Gelbwurz; Haldar; Curcumin I; Souchet; Haidr; Halad; Halud; Yellow Ginger; Terra Merita; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione; Safran d'Inde; Yo-Kin; C.I. Natural Yellow 3; Yellow puccoon; Diferaloylmethane; Tumeric yellow; CI Natural Yellow 3; Kurkumin; C.I. 75300; Zlut prirodni 3; Jianghuangsu; NanoCurc; E 100; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; NSC32982; NSC 32982; CCRIS 3257; CHEBI:3962; Lipocurc; Kurkum; HSDB 4334; 1,5-Di(vanillyliden)acetylaceton; CI 75300; NCI-C61325; 1,5-Divanillyliden-2,4-pentandion; EINECS 207-280-5; UNII-IT942ZTH98; NSC-32982; Curcumin e100; NSC 687842; trans,trans-Curcumin; BRN 2306965; IT942ZTH98; 1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione; E 100 (Dye); DTXSID8031077; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-; NSC-687842; (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; DTXCID901421; INS NO. 100(I); INS-100(I); 4-08-00-03697 (Beilstein Handbook Reference); 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-; curouma; kachs haldi; 2,7-Nonadiene-4,6-dione, 1,9-bis(4-hydroxy-3-methoxyphenyl)-; safra d'inde; CURCUMIN (MART.); CURCUMIN [MART.]; CURCUMIN (USP-RS); CURCUMIN [USP-RS]; Tumeric; Ukon; 1,7-BIS-(4-HYDROXY-3-METHOXYPHENYL)-HEPTA-1,6-DIENE-3,5-DIONE; Phytosome, Curcumin; Ukon (dye); C Yellow 15; Victory 19 Virus Out; CURCUMIN (CONSTITUENT OF TURMERIC); 1,7-BIS(4-HYDROXYMETHOXYPHENYL)-1,6-HEPTADIENE-3,5-DIONE; 207-280-5; e-100; e100; Curcuma; Golden seal; Curcumine; Hydrastis; Kurkumin [Czech]; Curcumin (synthetic); Zlut prirodni 3 [Czech]; Cucurmin; 94875-80-6; Tumeric oleoresin; MFCD00008365; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; Curcurmin; MLS000069631; CHEMBL140; SMR000058237; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-; (E/Z)-Curcumin; NSC687842; NCGC00017159-05; (1E,6E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hepta-1,6-diene-3,5-dione; (1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione; CAS-458-37-7; FEMA No. 3085; FEMA No. 3086; CCRIS 5804; SR-01000000149; Curcumin (Standard); starbld0017234; CURCUMIN [HSDB]; CURCUMIN [MI]; Opera_ID_1627; CURCUMIN [WHO-DD]; SCHEMBL8440; Curcumin, analytical standard; MLS001148449; BIDD:ER0479; CU-01000001305-2; cid_969516; GTPL7000; SCHEMBL13521974; BDBM29532; cid_5281767; HY-N0005R; MSK2436; cMAP_000052; HMS2233K04; HMS3649K06; HMS6019N06; BCP04695; Tox21_110803; Tox21_111505; Tox21_201116; BBL027711; BDBM50067040; BDBM50140172; CCG-36020; CCG-36107; SBB006495; STL371943; AKOS001305497; BCP9000557; DB11672; FC09321; NCGC00017159-04; NCGC00017159-06; NCGC00017159-07; NCGC00017159-09; NCGC00017159-10; NCGC00017159-11; NCGC00017159-12; NCGC00023332-03; NCGC00023332-04; NCGC00023332-05; NCGC00258668-01; AC-24238; AS-72202; BP-25396; ST055629; BCP0726000035; DB-002681; WLN: 1OR BQ E1U1V1V1U1R DQ CO1; C2302; CS-0149275; NS00014804; EN300-21494; F21478; K00009; Curcumin, Curcuma longa L. - CAS 458-37-7; Curcumin, primary pharmaceutical reference standard; Q312266; 1,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-; SR-01000000149-2; SR-01000000149-5; BRD-K07572174-001-02-2; BRD-K07572174-001-19-6; BRD-K07572174-001-22-0; BRD-K07572174-001-38-6; BRD-K07572174-001-39-4; Z104500108; Curcumin, >=94% (curcuminoid content), >=80% (Curcumin); 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione; 1,7-bis(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-dione; Curcumin, matrix substance for MALDI-MS, >=99.5% (HPLC); Curcumin, United States Pharmacopeia (USP) Reference Standard; 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione; 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione); (1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-1,6-diene-3,5-dione; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione #; (1E,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione; (1Z,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, (E,E)-; 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one; 5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one; Curcumin; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; (1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O Stabilizer C21H20O6 PD-L1 Q9NZQ7 . 10.3390/ijms24021413 TPD-B4E68O Gingerol gingerol; (S)-(6)-Gingerol; (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one; (S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; C17-H26-O4; UNII-925QK2Z900; CHEBI:10136; (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; 925QK2Z900; 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-; 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)-; 6-GINGEROL (CONSTITUENT OF GINGER); ccris 2037; 6-Gingerol; 23513-14-6; [6]-Gingerol; (6)-Gingerol; (S)-(+)-[6]Gingerol; 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-; (S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one; 1391-73-7; (+)-[6]-Gingerol; MFCD00210507; CHEMBL402978; BDBM50317427; 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (S)-(+)-[6]Gingerol;6-Gingerol; (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)decan-3-one; [6]-Gingerol (Standard); CBiol_001786; SCHEMBL32102; BSPBio_001347; KBioGR_000067; KBioSS_000067; (6)-GINGEROL [MI]; CHEMBL446043; GTPL2428; SHG-02; DTXSID3041035; KBio2_000067; KBio2_002635; KBio2_005203; KBio3_000133; KBio3_000134; NLDDIKRKFXEWBK-AWEZNQCLSA-N; Bio1_000072; Bio1_000561; Bio1_001050; Bio2_000067; Bio2_000547; HMS1361D09; HMS1791D09; HMS1989D09; HMS3402D09; SRCG-00265; [6]-Gingerol, analytical standard; BDBM50275147; CA-422; HY-14615R; MSK000358; s3836; [6]-Gingerol, >=98% (HPLC); AKOS015888215; CCG-208033; CCG-208214; CS-6333; FG09324; IDI1_033817; NCGC00163131-01; NCGC00163131-02; NCGC00163131-03; AC-33934; DS-12369; HY-14615; 1ST000358; NS00027445; C10462; 6-GINGEROL (CONSTITUENT OF GINGER) [DSC]; Q421081; SR-05000002341; SR-05000002341-2; BRD-K26117720-001-02-2; 5-Hydroxy-1-(4'-hydroxy-3'-methoxyphenyl)-3-decanone; (S)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl-3-decanone; [1-(4''-hydroxy-3''-methoxyphenyl)-5-hydroxy-3-decanone]; SHG-02, 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone, 6-Gingerol CCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1 Stabilizer C17H26O4 PD-L1 Q9NZQ7 . 10.3390/ijms24021413 TPD-LBWLTC CHEMBL5396148 3-[1-[1-[(E)-2-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]ethenyl]tetrazol-5-yl]ethylamino]propan-1-ol\; CHEMBL5396148; BDBM50633689 Cc1c(/C=C/n2nnnc2C(C)NCCCO)cccc1-c1ccc2c(c1)OCCO2 Stabilizer C23H27N5O3 PD-L1 Q9NZQ7 . 10.1039/d3md00746d TPD-L7HPA4 CHEMBL5419267 N-[[1-[(E)-2-(2-methyl-3-phenylphenyl)ethenyl]tetrazol-5-yl]methyl]ethanamine\; CHEMBL5419267; BDBM50633681; ~{N}-[[1-[(~{E})-2-(2-methyl-3-phenyl-phenyl)ethenyl]-1,2,3,4-tetrazol-5-yl]methyl]ethanamine; X1Q CCNCc1nnnn1/C=C/c1cccc(-c2ccccc2)c1C Stabilizer C19H21N5 PD-L1 Q9NZQ7 . 10.1039/d3md00746d TPD-UDDJ1D PD-L1 10.1039/d3md00746d Stabilizer Q9NZQ7 . PMID38665826_10l . Cc1c(/C=C/n2nnnc2CN2CCCOC2)cccc1-c1ccccc1 C21H23N5O TPD-KT7NGV PMID33202823_ZINC67902090 (3S,3aR,6S,6aR)-6-N-[4-(3-fluorophenyl)pyrimidin-2-yl]-3-N-(pyridin-2-ylmethyl)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diamine Fc1cccc(-c2ccnc(N[C@H]3CO[C@@H]4[C@@H](NCc5ccccn5)CO[C@H]34)n2)c1 Stabilizer C22H22FN5O2 PD-L1 Q9NZQ7 . 10.3390/molecules25225293 TPD-OGSBQ5 SCHEMBL29211308 1-Isopropyl-3-[(3s,5s)-1-methyl-5-[3-(2-naphthyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-3-yl]urea\; SCHEMBL29211308; 1-isopropyl-3-[(3s,5s)-1-methyl-5-[3-(2-naphthyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-3-yl]urea CC(C)NC(=O)N[C@H]1C[C@@H](c2nc(-c3ccc4ccccc4c3)no2)N(C)C1 Stabilizer C21H25N5O2 PD-L1 Q9NZQ7 . 10.3390/molecules25225293 TPD-LPI685 BI-0115 9-Chloro-5,11-dihydro-5-propyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one\; BI-0115; 4929-23-1; 9-chloranyl-5-propyl-11~{H}-pyrido[2,3-b][1,4]benzodiazepin-6-one; 9-Chloro-5,11-dihydro-5-propyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; CHEMBL5303404; EX-A5939; AKOS040759670; BB178547; BI-0115?; DA-51088; HY-23999; MS-24113; CS-0139778; NJT CCCN1C2=C(NC3=C(C1=O)C=CC(=C3)Cl)N=CC=C2 Stabilizer C15H14ClN3O LOX-1 P78380 . 10.1038/s42004-020-0321-2 TPD-OSMX1L 7-Nitro-4-(1-oxidopyridin-1-ium-2-yl)sulfanyl-2,1,3-benzoxadiazole 113104-25-9; NSC228155; NSC-228155; NSC 228155; 7-nitro-4-(1-oxidopyridin-1-ium-2-yl)sulfanyl-2,1,3-benzoxadiazole; MLS000756562; 2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)pyridine 1-oxide; 2-[(7-Nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio]pyridine 1-oxide; 2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]pyridin-1-ium-1-olate; CHEMBL505670; cid_313619; SCHEMBL22773985; BDBM25469; GLXC-04140; HMS2796J10; EX-A3226; NEA10425; s8312; AKOS033457659; CCG-267377; NSC228155?; BS-14426; DA-66225; SMR000448993; HY-101084; CS-0020796; D80527; EN300-128886; Z1582583180; 2-(7-Nitrobenzo[c][1,2,5]oxadiazol-4-ylthio)pyridine 1-oxide; 4-nitro-7-[(1-oxidopyridin-2-yl)sulfanyl]-2,1,3-benzoxadiazole; 2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-1-oxidopyridin-1-ium C1=CC=[N+](C(=C1)SC2=CC=C(C3=NON=C23)[N+](=O)[O-])[O-] Stabilizer C11H6N4O4S EGFR P00533 . 10.1038/srep03977 TPD-BXO7WH HCMV 10.1016/j.chembiol.2022.03.007 Stabilizer P16753 . PMID35364007_43 . O=C(CCl)Cn1nnc(-c2ccccc2)c1COC(=O)NCc1ccccc1 C20H19ClN4O3 TPD-FZU6JQ PMID30594165_D14 . C=C1C(Cl)=C(N2CCN(CC(=O)NCc3ccc4c(c3)OCO4)CC2)C=NN1c1ccccc1 Stabilizer C25H26ClN5O3 KRAS;PDE6D P01116/O43924 . 10.1186/s12885-018-5142-7 TPD-X74G3T PMID30594165_C22 . CC(NCC(=O)Nc1cccc(C(=O)CC2CC2)c1)c1ccc(Cl)cc1 Stabilizer C21H23ClN2O2 KRAS;PDE6D P01116/O43924 . 10.1186/s12885-018-5142-7 TPD-MYT5P6 PMID36561991_p39 . Cc1c(-c2ccccc2)cccc1N1C(=O)c2cc(CN[C@@H](C(=O)O)C(C)O)c(OCc3cccc(C#N)c3)cc2C1=O Stabilizer C34H29N3O6 PD-L1 Q9NZQ7 . 10.1016/j.apsb.2022.04.007 TPD-7226RQ Pevonedistat Pevonedistat; MLN4924; MLN 4924; pevonedistatum; Pevonedistat [USAN:INN]; UNII-S3AZD8D215; MLN-4924003; S3AZD8D215; TAK-924; PEVONEDISTAT [INN]; PEVONEDISTAT [USAN]; PEVONEDISTAT [WHO-DD]; TAK924; CHEBI:145535; ((1S,2S,4R)-4-(4-((1S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulphamate; [(1s,2s,4r)-4-{4-[(1s)-2,3-Dihydro-1h-Inden-1-Ylamino]-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl}-2-Hydroxycyclopentyl]methyl Sulfamate; Pevonedistat (USAN); ((1S,2S,4R)-4-(4-((1S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate; 4-(4-((1S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxycyclopentyl methyl sulfamidate; Sulfamic acid, ((1S,2S,4R)-4-(4-(((1S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl ester; ((1S,2S,4R)-4-(4-(((1S)-2,3-DIHYDRO-1H-INDEN-1-YL)AMINO(-7H-PYRROLO(2,3-D)PYRIMIDIN-7-YL)-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE; [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxy-cyclopentyl]methyl sulfamate; ((1S,2S,4R)-4-(4-(((1S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate; ((1S,2S,4R)-4-(4-(((1S)-2,3-dihydro-1H-inden-1-yl)amino)pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxy-cyclopentyl)methyl sulfamate; ((1S,2S,4R)-4-(4-((1S)-2,3-Dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulphamate; ((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate; [(1S,2S,4R)-4-(4-{[(1S)-2,3-dihydro-1H-inden-1-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl]methyl sulfamate; Nedd8-Activating Enzyme Inhibitor MLN4924; 905579-51-3; MLN-4924; ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate; Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester; Pevonedistat (MLN-4924); 905579-51-3 (free base); [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate; 3gzn; B39; MFCD17215201; Pevonedistat; MLN4924; Pevonedistat (USAN/INN); MLS006010830; SCHEMBL192875; CHEMBL1231160; CHEBI:95028; GTPL12117; MPUQHZXIXSTTDU-QXGSTGNESA-N; DTXSID701022549; EX-A1472; BDBM50285607; MLN-4924?; NSC793435; AKOS025401927; CS-0348; DB11759; FM16807; NSC-793435; NCGC00345794-02; NCGC00345794-07; NCGC00345794-09; NCGC00345794-10; [(1S,2S,4R)-4-{4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate; AC-27394; HY-70062; SMR004701757; NS00072840; D10413; BRD-K67844266-001-01-3; BRD-K67844266-003-01-9; Q27166792; Z2739897698; ((1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate; ((1S,2S,4R)-4-{4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]-pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate C1CC2=CC=CC=C2[C@H]1NC3=C4C=CN(C4=NC=N3)[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N Stabilizer C21H25N5O4S UBA3;NEDD8 Q8TBC4/Q15843 . 10.1007/978-981-15-1025-0_21 TPD-BXM8LE (S)-Thalidomide (S)-Thalidomide; (-)-Thalidomide; 841-67-8; Thalidomide, L-; S-(-)-Thalidomide; NSC 91730; CHEBI:61918; Phthalimide, N-(2,6-dioxo-3-piperidyl)-, (-)-; Phthalimide, N-(2,6-dioxo-3-piperidyl)-, L-(-)-; DTXSID1046972; 2-[(3S)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-, (S)-; 2-((3S)-2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione; DTXCID9026972; 635-910-2; (S)-(-)-thalidomide; l-Thalidomide; S-Thalidomide; Thalidomide, (-)-; (S)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; TG87FSR590; 2-[(3S)-2,6-dioxopiperidin-3-yl]-2,3-dihydro-1H-isoindole-1,3-dione; SMR000857221; Thalidomide, (S)-; ENMD 0995; UNII-TG87FSR590; NSC-91730; CAS-50-35-1; EF2; Tocris-0652; 4ci1; Lopac-T-144; MLS001333073; MLS001333074; rac-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; SCHEMBL455269; CHEMBL426123; 2-[(3S)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione; BDBM65457; ENMD-0995; EX-A7843G; HMS2230K15; (-)-Thalidomide, >98%, solid; HY-14658A; AKOS040736375; NCGC00015989-01; NCGC00015989-02; NCGC00016220-01; NCGC00024708-01; BP-40471; DA-48869; MS-23635; CS-0021928; NS00099188; G12479; EN300-7507076; A828082; S(-)-3-(3-AMINO-PHTHALIMIDO)-GLUTARAMIDE; Thalidomide; N-(2,6-dioxo-3-piperidyl)phalimide; Q27131493; 2-[(3S)-2,6-dioxo-3-piperidinyl]isoindole-1,3-dione; 2-[(3S)-2,6-bis(oxidanylidene)piperidin-3-yl]isoindole-1,3-dione O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1 Degrader C13H10N2O4 CK1α;IKZF1;IKZF3;Delta Np63;Transactivation p63;SALL4 P48729/Q13422/Q9UKT9/Q9H3D4-2/Q9H3D4-1/Q9UJQ4 CRBN 10.1038/nature16979&10.1038/s41589-019-0366-7&10.7554/eLife.38430 TPD-QKBHW5 Lenalidomide, (S)- 202271-91-8; Lenalidomide, (S)-; 82TY7L06PO; UNII-82TY7L06PO; (S)-3-(4-Amino-1-oxoisoindolin-2-yl)piperidin-2,6-dione; (S)-3-(4-Amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione; 2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, (S)-; 2,6-piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, (3S)-; S-Lenalidomide; (S)-3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; (3S)-3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione; (S)-Lenalidomide; LVY; 4ci2; SCHEMBL868339; GLXC-04181; AKOS015913937; AT18295; GS-9756; NCGC00167491-06; PD132533; CS-0197835; Q27462749; (3S)-3-(4-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione Nc1cccc2c1CN([C@H]1CCC(=O)NC1=O)C2=O Degrader C13H13N3O3 CK1α;IKZF1;IKZF3;CYP19A1;SALL4;IRF4 P48729/Q13422/Q9UKT9/P11511/Q9UJQ4/Q15306 CRBN 10.1038/nature16979&10.7554/eLife.38430&10.1182/blood.2020005296&/10.1111/j.1365-2141.2011.08689.x TPD-X0AXX0 Pomalidomide, (S)- 202271-89-4; Pomalidomide, (S)-; Pomalidomide, (-)-; 2EE4M42K6G; (S)-CC-4047; UNII-2EE4M42K6G; (S)-4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3S)-2,6-dioxo-3-piperidinyl)-; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-, (S)-; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-((3S)-2,6-dioxo-3-piperidinyl)-, (-)-; (S)-pomalidomide; S-Pomalidomide; 4-AMINO-2-[(3S)-2,6-DIOXOPIPERIDIN-3-YL]ISOINDOLE-1,3-DIONE; (s)-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; S-3APG; Y70; 4ci3; SCHEMBL563317; CHEMBL2093113; GLXC-20932; AT41382; PD132344; CS-0040920; NS00069624; Q27254625; 4-amino-2-[(3S)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione; (S)-Pomalidomide; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-[(3S)-2,6-dioxo-3-piperidinyl]- (9CI, ACI); 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-, (S)- (ZCI); 4-Amino-2-[(3S)-2,6-dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione (ACI); (S)-4-Amino-2-(2,6-d Nc1cccc2c1C(=O)N([C@H]1CCC(=O)NC1=O)C2=O Degrader C13H11N3O4 SALL4;ZNF692;IKZF1;CK1α;IKZF3;ARID2;CYP19A1 Q9UJQ4/Q9BU19/Q13422/P48729/Q9UKT9/Q68CP9/P11511 CRBN 10.1038/nature16979&10.7554/eLife.38430&10.1182/blood.2020005296&10.1038/s41589-020-0645-3 TPD-YY6X3N JH-RE-06 8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one\; JH-RE-06; 1361227-90-8; 8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one; 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one; CHEMBL2012449; SCHEMBL24186005; GLXC-21219; EX-A7581; LEC22790; s8850; AKOS040741893; DA-54530; MS-28659; HY-126214; CS-0099826; G16889; 8-Chloro-2-(2,4-dichlorophenylamino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one; 8-Chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methylbutanoyl)-5-nitro-4(1H)-quinolinone; EQ7 CC(C)CC(=O)C1=C(NC2=C(C=CC(=C2C1=O)[N+](=O)[O-])Cl)NC3=C(C=C(C=C3)Cl)Cl Stabilizer C20H16Cl3N3O4 REV1 Q9UBZ9 . 10.1016/j.cell.2019.05.028 TPD-REZY04 CU-CPT-8m CU-CPT-8m; 125079-83-6; 7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; CU-CPT8m; 7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; CHEMBL4553089; 7-(3-methylphenyl) pyrazolo(1,5-a)pyrimidine-3-carboxamide; 7-(3-methylphenyl) pyrazolo[1,5-a]pyrimidine-3-carboxamide; CU-CPT-8m?; GTPL9795; SCHEMBL8331920; CPD1578; HNKGGVGQAVODNJ-UHFFFAOYSA-N; AFA07983; BCP29123; EX-A2834; BDBM50587872; AKOS037648653; compound 5 [PMID: 29155428]; AC-37096; BS-15070; DB-170423; HY-112050; CS-0042512; S4461; 7-M-tolylpyrazolo[1,5-a]pyrimidine-3-carboxamide Cc1cccc(-c2ccnc3c(C(N)=O)cnn23)c1 Stabilizer C14H12N4O TLR8 Q9NR97 . 10.1038/nchembio.2518 TPD-9QW02U 4-(7-Methoxyquinolin-4-yl)-2-methylphenol 2165340-32-7; CU-CPT-9a; 4-(7-methoxyquinolin-4-yl)-2-methylphenol; 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol; CU CPT 9a; CU-CPT9a; 4-(7-Methoxy-4-quinolinyl)-2-methylphenol; CHEMBL4790706; 4-(7-methoxyquinolin-4-yl)-2-methyl-phenol; CU-CPT-9a?; Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl-; 6BNV86VAQ8; SCHEMBL23496982; DTXSID301336685; BCP29122; EX-A3051; QLD34032; BDBM50552139; s9730; AKOS037649077; AC-36561; BS-16510; SY235752; DB-150169; HY-112667; CS-0059157; 2-Methyl-4-(7-methoxyl-4-quinolinyl)-phenol; 7VC COc1ccc2c(-c3ccc(O)c(C)c3)ccnc2c1 Stabilizer C17H15NO2 TLR8 Q9NR97 . 10.1038/nchembio.2518 TPD-QFTKZC CU-CPT9b CU-CPT9b; 2162962-69-6; CU-CPT-9b; 4-(4-hydroxy-3-methylphenyl)quinolin-7-ol; CHEMBL5176610; 4-(3-methyl-4-oxidanyl-phenyl)quinolin-7-ol; 2-Methyl-4-(7-hydroxy-4-quinolinyl)phenol; CU-CPT-9b?; SCHEMBL23496974; EX-A2833; MLD96269; BDBM50587871; AKOS037648876; AC-37114; BS-15918; DB-150168; HY-112051; CS-0042513; 2-Methyl-4-(7-hydroxyl-4-quinolinyl)-phenol; 7VF Cc1cc(-c2ccnc3cc(O)ccc23)ccc1O Stabilizer C16H13NO2 TLR8 Q9NR97 . 10.1038/nchembio.2518 TPD-F7TT2C GTPL13440 3-[6-[(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL23532750; GTPL13440; compound C [PMID: 38963839]; 3-[6-[(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CCN1CCCC[C@@H]1[C@@H](C)Oc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H29N3O4 WIZ O95785 CRBN 10.1126/science.adk6129 TPD-VX2DZA HbF inducer 2 HbF inducer 2; DWIZ-2; 2654011-51-3; 3-[6-[[(2R)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; dWIZ2; dWIZ 2; SCHEMBL23532590; CHEBI:233640; EX-A9597; HY-159099; CS-1170547; 3-(5-{[(2R)-1-ethylpiperidin-2-yl]methoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione CCN1CCCC[C@@H]1COc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C21H27N3O4 WIZ O95785 CRBN 10.1126/science.adk6129 TPD-SGHDD9 Iberdomide Iberdomide; 1323403-33-3; cc-220; (S)-3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; Iberdomide [USAN]; Iberdomida; CC220; IBERDOMIDE [INN]; 8V66F27X44; IBERDOMIDE [WHO-DD]; (3S)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; compound 6 [PMID: 28425720]; (3s)-3-[4-({4-[(Morpholin-4-Yl)methyl]phenyl}methoxy)-1-Oxo-1,3-Dihydro-2h-Isoindol-2-Yl]piperidine-2,6-Dione; (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione; 2,6-Piperidinedione, 3-(1,3-dihydro-4-((4-(4-morpholinylmethyl)phenyl)methoxy)-1-oxo-2H-isoindol-2-yl)-, (3S)-; compound 6 (PMID: 28425720); iberdomidum; (3S)-3-(4-((4-((MORPHOLIN-4-YL)METHYL)PHENYL)METHOXY)-1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PIPERIDINE-2,6-DIONE; (3S)-3-(4-((4-((morpholin-4-yl)methyl)phenyl)methoxy)-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione; (3S)-3-(7-((4-(morpholin-4-ylmethyl)phenyl)methoxy)-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione; CC 220; (S)-3-[4-(4-Morpholin-4-yl-methyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione; Iberdomide?; 8W7; Iberdomide(CC220); Iberdomide (CC220); Iberdomide (USAN/INN); CC-220 (Compound 6); IBERDOMIDE(CC-220); GTPL9618; SCHEMBL2252414; CC 220;CC-220;Iberdomide; CHEMBL3989927; UNII-8V66F27X44; BDBM65497; IXZOHGPZAQLIBH-NRFANRHFSA-N; GLXC-10664; BCP20299; EX-A1425; NSC833899; s8760; AKOS032946272; CS-6511; DB12101; NSC-833899; AC-32713; BP-28980; FM158574; HY-101291; NS00073394; C72310; D11134; EN300-22733380; Q27271066; Z5255528570 C1CC(=O)NC(=O)[C@H]1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5 Degrader C25H27N3O5 SALL4;IKZF1;IKZF3 Q9UJQ4/Q13422/Q9UKT9 CRBN 10.1021/acs.jmedchem.6b01921 TPD-3MZM5Q SCHEMBL27312390 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-[(E)-3-[4-(trifluoromethyl)phenyl]prop-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312390 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)/C=C/c5ccc(C(F)(F)F)cc5)CC4)cn3)nc2n1C1CCCC1 Degrader C33H35F3N8O2 CDK4 P11802 RNF126 10.1021/acscentsci.2c01317 TPD-183CAB SCHEMBL27312393 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-[3-[4-(trifluoromethyl)phenyl]propanoyl]piperazin-1-yl]pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312393 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)CCc5ccc(C(F)(F)F)cc5)CC4)cn3)nc2n1C1CCCC1 Degrader C33H37F3N8O2 CDK4 P11802 RNF126 10.1021/acscentsci.2c01317 TPD-06PRMR SCHEMBL27312548 7-cyclopentyl-2-[[5-[4-[(E)-4-(4-methoxyphenyl)-4-oxobut-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312548 COc1ccc(C(=O)/C=C/C(=O)N2CCN(c3ccc(Nc4ncc5cc(C(=O)N(C)C)n(C6CCCC6)c5n4)nc3)CC2)cc1 Degrader C34H38N8O4 CDK4 P11802 RNF126 10.1021/acscentsci.2c01317 TPD-351RMC PMID37252349_EST1089 . COc1ccc(C(=O)/C=C/C(=O)N2CCN(c3ccc(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5N4)nc3)CC2)cc1 Degrader C35H39N7O5 CDK4 P11802 RNF126 10.1021/acscentsci.2c01317 TPD-0N0SXN BRD4 degrader-2 BRD4 degrader-2; SCHEMBL27312876; CS-1096689 COc1ccc(C(=O)/C=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)cc1 Degrader C34H33ClN6O4S BRD4 O60885 RNF126 10.1021/acscentsci.2c01317 TPD-D1XTM4 SCHEMBL27312729 (E)-1-[4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27312729 CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C(=O)/C=C/C(=O)c5ccc(OC)cc5)CC4)ccc3OCC)nc12 Degrader C32H36N6O7S PDE5 O76074 RNF126 10.1021/acscentsci.2c01317 TPD-L5NYVF SCHEMBL27312885 (E)-1-(4-methoxyphenyl)-4-[4-[2-[4-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenoxy]acetyl]piperazin-1-yl]but-2-ene-1,4-dione\; SCHEMBL27312885 COc1ccc(C(=O)/C=C/C(=O)N2CCN(C(=O)COc3ccc(-c4csc(N5CCOCC5)n4)cc3)CC2)cc1 Degrader C30H32N4O6S AR;AR-V7 P10275/P10275-3 RNF126 10.1021/acscentsci.2c01317 TPD-OYEMEO SCHEMBL27312886 (E)-1-(4-methoxyphenyl)-4-[4-[4-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenyl]piperazin-1-yl]but-2-ene-1,4-dione\; SCHEMBL27312886 COc1ccc(C(=O)/C=C/C(=O)N2CCN(c3ccc(-c4csc(N5CCOCC5)n4)cc3)CC2)cc1 Degrader C28H30N4O4S AR;AR-V7 P10275/P10275-3 RNF126 10.1021/acscentsci.2c01317 TPD-EDXNSI SCHEMBL27312725 N-(2-chloro-6-methylphenyl)-2-[[6-[4-[(E)-4-(4-methoxyphenyl)-4-oxobut-2-enoyl]piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide\; SCHEMBL27312725 COc1ccc(C(=O)/C=C/C(=O)N2CCN(c3cc(Nc4ncc(C(=O)Nc5c(C)cccc5Cl)s4)nc(C)n3)CC2)cc1 Degrader C31H30ClN7O4S BCR-ABL;c-ABL Q16189/P00519 RNF126 10.1021/acscentsci.2c01317 TPD-DFIE00 SCHEMBL27312734 (E)-1-[4-[4-[[5-chloro-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxybenzoyl]piperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27312734 CNc1nc(Nc2ccc(C(=O)N3CCN(C(=O)/C=C/C(=O)c4ccc(OC)cc4)CC3)cc2OC)ncc1Cl Degrader C28H29ClN6O5 LRRK2 Q5S007 RNF126 10.1021/acscentsci.2c01317 TPD-CIT225 SCHEMBL27312882 (E)-1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27312882 COc1ccc(C(=O)/C=C/C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)C2)cc1 Degrader C33H30N6O4 BTK Q06187 RNF126 10.1021/acscentsci.2c01317 TPD-0TDUTI JP-2-249 (E)-1-[4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27312731; JP-2-249; HY-161883 COc1ccc(C(=O)/C=C/C(=O)N2CCN(c3cc(-c4ccccc4O)nnc3N)CC2)cc1 Degrader C25H25N5O4 SMARCA2;SMARCA4 P51531/P51532 RNF126 10.1021/acscentsci.2c01317 TPD-4VQHQ0 CHEMBL461557 (2~{R})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol\; CHEMBL461557; (2~{R})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; DS16; SCHEMBL17628573; BRJSFOFBYVFKCP-OAQYLSRUSA-N; BDBM50378235; (R)-2-(6-(Biphenyl-4-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol; RNF CC[C@H](CO)Nc1nc(NCc2ccc(-c3ccccc3)cc2)c2ncn(C(C)C)c2n1 Degrader C25H30N6O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-3OAEPG RSU (2~{R})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol\; (2~{R})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; DS11; RSU CC[C@H](CO)Nc1nc(NCCCc2ccccc2)c2ncn(C(C)C)c2n1 Degrader C21H30N6O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-7MPHA6 DS17 (2R)-2-[[6-[(5,6-dichloro-1H-benzimidazol-2-yl)methylamino]-9-propan-2-ylpurin-2-yl]amino]butan-1-ol\; DS17; HY-160501; CS-0998476 CC[C@H](CO)Nc1nc(NCc2nc3cc(Cl)c(Cl)cc3[nH]2)c2ncn(C(C)C)c2n1 Degrader C20H24Cl2N8O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-KFU1V0 RVQ N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-propan-2-ylpurin-6-amine\; RVQ; DS18 CC(C)n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(N3CCOCC3)nc21 Degrader C20H22Cl2N8O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-Q2IZ5C DS19 2-morpholin-4-yl-9-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]purin-6-amine\; 2-morpholin-4-yl-9-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]purin-6-amine; DS19; LQFDMFLOSFCOEO-UHFFFAOYSA-N; Rsi CC(C)n1cnc2c(NCc3ccc(-c4ccccn4)cc3)nc(N3CCOCC3)nc21 Degrader C24H27N7O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-5IKCFI DS55 N-(1H-benzimidazol-2-ylmethyl)-9-(1-methylpyrazol-4-yl)-2-morpholin-4-ylpurin-6-amine\; DS55; RQE Cn1cc(-n2cnc3c(NCc4nc5ccccc5[nH]4)nc(N4CCOCC4)nc32)cn1 Degrader C21H22N10O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-SAB574 DS61 2-[[6-[[4-(2-Hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol\; 2-[[6-[[4-(2-hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; DS61; RQ5 CC[C@H](CO)Nc1nc(NCc2ccc(OCCO)cc2)c2ncn(C(C)C)c2n1 Degrader C21H30N6O3 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-5K0POH DS74 N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-8-(1-methylpyrazol-4-yl)-2-morpholin-4-ylpyrazolo[1,5-a][1,3,5]triazin-4-amine\; DS74; SCHEMBL23497422 Cn1cc(-c2cnn3c(NCc4nc5cc(Cl)c(Cl)cc5[nH]4)nc(N4CCOCC4)nc23)cn1 Degrader C21H20Cl2N10O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-Y2TND7 DS71 8-bromo-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)pyrazolo[1,5-a][1,3,5]triazin-4-amine\; DS71; SCHEMBL23508337 CN1CCN(c2nc(NCc3nc4c(F)c(F)ccc4[nH]3)n3ncc(Br)c3n2)CC1 Degrader C18H18BrF2N9 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-YJ29RT DS72 8-bromo-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-ylpyrazolo[1,5-a][1,3,5]triazin-4-amine\; DS72; SCHEMBL23497424 Fc1ccc2[nH]c(CNc3nc(N4CCOCC4)nc4c(Br)cnn34)nc2c1F Degrader C17H15BrF2N8O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-1LG6JA DS73 8-bromo-N-[(5,6-dimethyl-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)pyrazolo[1,5-a][1,3,5]triazin-4-amine\; DS73; SCHEMBL23508458 Cc1cc2nc(CNc3nc(N4CCN(C)CC4)nc4c(Br)cnn34)[nH]c2cc1C Degrader C20H24BrN9 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-4EKW3Y DS64 (2R)-2-[[6-[(4,5-difluoro-1H-benzimidazol-2-yl)methylamino]-9-propan-2-ylpurin-2-yl]amino]butan-1-ol\; DS64 CC[C@H](CO)Nc1nc(NCc2nc3ccc(F)c(F)c3[nH]2)c2ncn(C(C)C)c2n1 Degrader C20H24F2N8O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-NLRZ5F SR-4835 N-((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)-9-(1-methyl-1H-pyrazol-4-yl)-2-morpholino-9H-purin-6-amine\; 2387704-62-1; SR-4835; N-((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)-9-(1-methyl-1H-pyrazol-4-yl)-2-morpholino-9H-purin-6-amine; MFCD32263441; N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine; CHEMBL4877117; RMF; SR 4835; SCHEMBL21566990; BCP33214; EX-A3449; NWD28632; BDBM50584000; s8894; AKOS037649005; SR4835; SR 4835; AC-36889; BS-16231; BS180614; N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-ylpurin-6-amine; SR-4835?; SY325624; HY-130250; CS-0106031; D81560; N-[(5,6-dichloro-1H-1,3-benzodiazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(morpholin-4-yl)-9H-purin-6-amine; N-[(5,6-Dichloro-2-benzoimidazolyl)methyl]-9-(1-methyl-4-pyrazolyl)-2-morpholino-9H-purin-6-amine CN1C=C(C=N1)N2C=NC3=C(N=C(N=C32)N4CCOCC4)NCC5=NC6=CC(=C(C=C6N5)Cl)Cl Degrader C21H20Cl2N10O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-F9JHWF ISIR-005 (4aR,6S,7R,8R,8aS)-6-[[(1E,3R,8R,9R,10R,11S,14S)-9-hydroxy-14-(methoxymethyl)-3,10-dimethyl-6-propan-2-yl-8-tricyclo[9.3.0.03,7]tetradeca-1,6-dienyl]oxy]-2,2-dimethyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-7,8-diol\; ISIR-005; CHEMBL4218471; ISIR005; GLXC-15258; BDBM50454783; AKOS040752109; (4aR,6S,7R,8R,8aS)-6-(((4R,5R,6R,6aS,9S,10aR,E)-5-Hydroxy-3-isopropyl-9-(methoxymethyl)-6,10a-dimethyl-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl)oxy)-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxine-7,8-diol C[C@@H]1[C@@H]\2CC[C@@H](/C2=C/[C@]3(CCC(=C3[C@H]([C@@H]1O)O[C@@H]4[C@@H]([C@H]([C@H]5[C@H](O4)COC(O5)(C)C)O)O)C(C)C)C)COC Stabilizer C30H48O8 14-3-3ζ;Gab2 P63104/Q9UQC2 . 10.1002/cmdc.201500484 TPD-YQ5GU2 G6PD activator AG1 G6PD activator AG1; 421581-52-4; 2-(1H-indol-3-yl)-N-[2-[2-[2-(1H-indol-3-yl)ethylamino]ethyldisulfanyl]ethyl]ethanamine; CHEMBL5172312; 2,2'-disulfanediylbis(N-(2-(1H-indol-3-yl)ethyl)ethan-1-amine); ChemDiv1_010489; HMS616M17; CHEBI:143872; EX-A3989; WRA58152; BDBM50630970; AKOS040733215; DA-63655; MS-27872; HY-123962; CS-0087691; G12938; N,N'-(disulfanediyldiethane-2,1-diyl)bis[2-(1H-indol-3-yl)ethanamine]; N,N'-[disulfanediyldi(ethane-2,1-diyl)]bis[2-(1H-indol-3-yl)ethan-1-amine] c1ccc2c(CCNCCSSCCNCCc3c[nH]c4ccccc34)c[nH]c2c1 Stabilizer C24H30N4S2 G6PD P11413 . 10.1002/cmdc.201900341 TPD-LD1R2I PMID30025189_FC-NAc . C=CC(C)(C)OCC1OC(O[C@@H]2C3=C([C@H](C)CNC(C)=O)C[C@H](O)[C@]3(C)/C=C3/[C@@H](COC)CC[C@H]3[C@@H](C)[C@H]2O)C(O)C(O)C1O Stabilizer C34H55NO10 14-3-3σ;TASK-3 P31947/Q9NPC2 . 10.1002/anie.201806584 TPD-4KZKO6 N-(2,3-Dihydro-1H-inden-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine N-(2,3-Dihydro-1H-inden-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine; 1997359-63-3; CHEMBL3923120; SCHEMBL18353882; GLXC-15949; BDBM50196528; MFCD32876882; JZ-4109; SY278540; N-(2,3-Dihydro-1H-inden-2-yl)-2-(pyridin-3-yl)quinazolin-4- amine C1C(CC2=CC=CC=C21)NC3=NC(=NC4=CC=CC=C43)C5=CN=CC=C5 Stabilizer C22H18N4 GCase P04062 . 10.1021/jacs.7b13003 TPD-EE3ZSG Bay-2666605 BAY-2666605; BAY2666605; 2H-1,3,4-Oxadiazin-2-one, 5-(4'-fluoro-2-(trifluoromethyl)(1,1'-biphenyl)-4-yl)-3,6-dihydro-6-methyl-, (6S)-; Schlafen12 Complex Inducer BAY 2666605; SLFN12-PDE3A Complex Inducer BAY 2666605; SLFN12/PDE3A Complex Inducer BAY 2666605; BAY 2666605; 2275774-60-0; XC4ZA6OSY6; UNII-XC4ZA6OSY6; (6S)-5-[4-(4-fluorophenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one; orb1297869; CHEMBL5268644; SCHEMBL20705325; JNTJTCXFIXNXDV-VIFPVBQESA-N; BDBM568674; EX-A6040; NSC841296; US11427553, Example 135; AKOS040759979; NSC-841296; MS-25453; SY345646; HY-145924; CS-0435253; F78349; (6S)-5-[4'-Fluoro-2-(trifluoromethyl)biphenyl-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (S)-5-(4'-Fluoro-2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (S)-5-[4 inverted exclamation mark -Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one C[C@H]1C(=NNC(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)F)C(F)(F)F Stabilizer C17H12F4N2O2 PDE3A;SLFN12 Q14432/Q8IYM2 . 10.1021/acsmedchemlett.4c00336 TPD-TU9F23 Elironrasib RMC-6291; Elironrasib; 2641998-63-0; GTPL12622; RMC6291; elironrasib [INN]; 942KVV5CJP; CHEMBL5437500; SCHEMBL23325010; GLXC-27384; EX-A7663; NSC851965; AT45105; NSC-851965; DA-57470; HY-153346; CS-0694006; 1-[4-(dimethylamino)-4-methylpent-2-ynoyl]-N-[(2S)-1-[[(6S,8S,14S)-22-ethyl-21-[2-[(1S)-1-methoxyethyl]pyridin-3-yl]-18,18-dimethyl-9,15-dioxo-5,16-dioxa-2,10,22,28-tetrazapentacyclo[18.5.2.12,6.110,14.023,27]nonacosa-1(26),20,23(27),24-tetraen-8-yl]amino]-3-methyl-1-oxobutan-2-yl]-4-fluoro-N-methylpiperidine-4-carboxamide; 3-Pyridazinecarboxylic acid, N1-[N-[[1-[4-(dimethylamino)-4-methyl-1-oxo-2-pentyn-1-yl]-4-fluoro-4-piperidinyl]carbonyl]-N-methyl-L-valyl-3-[4-[(2R)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-3-pyridinyl]-1H-indol-5-yl]-2-morpholinyl]-L-alanyl]hexahydro-, (3-->2)-lactone, (3S)- CCN1C2=C3C=C(C=C2)N4CCO[C@H](C4)C[C@@H](C(=O)N5CCC[C@H](N5)C(=O)OCC(CC3=C1C6=C(N=CC=C6)[C@H](C)OC)(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)C7(CCN(CC7)C(=O)C#CC(C)(C)N(C)C)F Stabilizer C55H78FN9O8 KRAS;CypA P01116/P62937 . 10.1021/acs.jmedchem.4c02313 TPD-049ESM CHEMBL4638669 3-(3-oxo-7-phenylmethoxy-1H-isoindol-2-yl)piperidine-2,6-dione; SCHEMBL10208068; Z5027900654 O=C1N(CC2=C(OCC3=CC=CC=C3)C=CC=C12)C1CCC(=O)NC1=O Degrader C20H18N2O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-3WSCIS 32130004_34 . CN1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C26H30N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-J1XBDQ 32130004_27 . CC1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C27H31N3O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-HHQA5U SCHEMBL2250612 3-[7-[[4-[(4,4-difluoropiperidin-1-yl)methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; CHEMBL4647343; SJEKUWBPPUMDIN-UHFFFAOYSA-N; 3-[7-[[4-[(4,4-difluoropiperidin-1-yl)methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1(F)CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C26H27F2N3O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-QM5UZP SCHEMBL2251418 3-[7-[[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; CHEMBL4646021 CC1(C)CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C28H33N3O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-YPBY07 SCHEMBL2254664 3-[3-oxo-7-[[4-[(4-propan-2-ylpiperidin-1-yl)methyl]phenyl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione; CHEMBL4645982 CC(C)C1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C29H35N3O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-S97N5C SCHEMBL2250989 3-[3-oxo-7-[[4-[[4-(trifluoromethyl)piperidin-1-yl]methyl]phenyl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione; CHEMBL4641342; SCHEMBL29790787; JXIAZCAMKCEWTF-UHFFFAOYSA-N; 3-[3-oxo-7-[[4-[[4-(trifluoromethyl)piperidin-1-yl]methyl]phenyl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione FC(F)(F)C1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C27H28F3N3O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-8GT4MX SCHEMBL2246406 3-[3-oxo-7-[[4-[(4-propan-2-ylpiperazin-1-yl)methyl]phenyl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione; CHEMBL4642197 CC(C)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C28H34N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-N17T1H SCHEMBL2251457 3-[3-oxo-7-[[4-[(4-phenylpiperazin-1-yl)methyl]phenyl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione; CHEMBL4647905 O=C1N(CC2=C(OCC3=CC=C(CN4CCN(CC4)C4=CC=CC=C4)C=C3)C=CC=C12)C1CCC(=O)NC1=O Degrader C31H32N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-AE1BU7 SCHEMBL2249767 3-[7-[[4-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; CHEMBL4640365 FC1=CC=C(C=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H31FN4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-5EA3Q8 SCHEMBL2249574 3-[3-oxo-7-[[4-[(4-pyridin-2-ylpiperazin-1-yl)methyl]phenyl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione; CHEMBL4642361; SCHEMBL12372072 O=C1N(CC2=C(OCC3=CC=C(CN4CCN(CC4)C4=NC=CC=C4)C=C3)C=CC=C12)C1CCC(=O)NC1=O Degrader C30H31N5O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-OQ6I6N SCHEMBL2248920 2-(2,6-Dioxopiperidin-3-yl)-4-[[4-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]isoindole-1,3-dione; CHEMBL4644747 FC1=CC=C(C=C1)N1CCN(CC2=CC=C(COC3=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H29FN4O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-7G52P3 CHEMBL4645677 3-[7-[[4-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL2249933; SCHEMBL30084096; BDBM50545275 FC1=CC(F)=C(C=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H30F2N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-G7IGSR CHEMBL4636670 3-[7-[[4-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione ClC1=CC=C(C=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H31ClN4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-4S932U CHEMBL4642904 3-[7-[[4-[[4-(2,4-dichlorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione ClC1=CC(Cl)=C(C=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H30Cl2N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-H4RLX4 CHEMBL4645692 3-[7-[[4-[[4-(2,6-difluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1=CC=CC(F)=C1N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H30F2N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-ZJNNKD CHEMBL4638224 3-[7-[[4-[[4-(3-fluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1=CC=CC(=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H31FN4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-FC6JQP CHEMBL4641034 3-[7-[[4-[[4-(2-fluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1=C(C=CC=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H31FN4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-C9O9JF CHEMBL4647512 3-[7-[[4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC1=CC=C(C=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C32H34N4O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-BBJ4HQ CHEMBL4634712 3-[7-[[4-[[4-(5-fluoropyridin-2-yl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1=CC=C(N=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C30H30FN5O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-2IUM4C CHEMBL4642706 2-[4-[[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]pyridine-3-carbonitrile O=C1N(CC2=C(OCC3=CC=C(CN4CCN(CC4)C4=C(C=CC=N4)C#N)C=C3)C=CC=C12)C1CCC(=O)NC1=O Degrader C31H30N6O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-V5SFQ5 CHEMBL4636184 3-[7-[[4-[4-(2,4-difluorophenyl)piperazine-1-carbonyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1=CC(F)=C(C=C1)N1CCN(CC1)C(=O)C1=CC=C(COC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CC=C2)C=C1 Degrader C31H28F2N4O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-EJ6Z25 CHEMBL4639846 5-[4-[[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]pyridine-2-carboxamide NC(=O)C1=NC=C(C=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H32N6O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-49N0TZ CHEMBL4637801 (S)-4-[4-[4-[[[2-(2,6-Dioxo-3-piperidyl)-1-oxo-4-isoindolinyl]oxy]methyl]benzyl]-1-piperazinyl]-3-fluorobenzonitrile; SCHEMBL20608547; SCHEMBL29444146; JQD64880; BDBM50545276 FC1=CC(=CC=C1N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1)C#N Degrader C32H30FN5O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-VAMT79 CHEMBL4637622 3-[7-[[4-[4-(2,4-dichlorophenyl)piperazine-1-carbonyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione ClC1=CC(Cl)=C(C=C1)N1CCN(CC1)C(=O)C1=CC=C(COC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CC=C2)C=C1 Degrader C31H28Cl2N4O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-04YR73 CHEMBL4648954 3-[7-[[4-[4-(4-fluorophenyl)piperazine-1-carbonyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1=CC=C(C=C1)N1CCN(CC1)C(=O)C1=CC=C(COC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CC=C2)C=C1 Degrader C31H29FN4O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-KIJ8SV CHEMBL4644660 3-[7-[[4-[4-(4-chlorophenyl)piperazine-1-carbonyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione ClC1=CC=C(C=C1)N1CCN(CC1)C(=O)C1=CC=C(COC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CC=C2)C=C1 Degrader C31H29ClN4O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-1IBT9K CHEMBL4645264 3-[7-[[4-[[4-(2,4-dichlorophenyl)-2-oxopiperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione ClC1=CC(Cl)=C(C=C1)N1CCN(CC2=CC=C(COC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)C(=O)C1 Degrader C31H28Cl2N4O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-FZARAW CHEMBL4634342 (3R)-3-[7-[[4-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1=CC(F)=C(C=C1)N1CCN(CC2=CC=C(COC3=C4CN([C@@H]5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H30F2N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-9QEZYK CHEMBL4647587 (3S)-3-[7-[[4-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1=CC(F)=C(C=C1)N1CCN(CC2=CC=C(COC3=C4CN([C@H]5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H30F2N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-ZHDQXN CHEMBL4645905 3-[7-[[4-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]phenyl]methylamino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione FC1=CC(F)=C(C=C1)N1CCN(CC2=CC=C(CNC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C31H31F2N5O3 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-ID4JCD CHEMBL4645330 3-[7-[[4-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]-1-methylpiperidine-2,6-dione CN1C(=O)CCC(N2CC3=C(C=CC=C3OCC3=CC=C(CN4CCN(CC4)C4=C(F)C=C(F)C=C4)C=C3)C2=O)C1=O Degrader C32H32F2N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-14ZFQ7 CHEMBL4642316 4-[[4-[[4-(2,4-Dichlorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione ClC1=CC(Cl)=C(C=C1)N1CCN(CC2=CC=C(COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)CC1 Degrader C31H28Cl2N4O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-W0U5JO CHEMBL4645564 4-[[4-[[4-(2,4-Difluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione FC1=CC(F)=C(C=C1)N1CCN(CC2=CC=C(COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)CC1 Degrader C31H28F2N4O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-5HJED0 CHEMBL4643439 (3R)-3-[7-[[4-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]-3-methylpiperidine-2,6-dione C[C@]1(CCC(=O)NC1=O)N1CC2=C(C=CC=C2OCC2=CC=C(CN3CCN(CC3)C3=CC=C(F)C=C3F)C=C2)C1=O Degrader C32H32F2N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-19MYS5 CHEMBL4648463 (3S)-3-[7-[[4-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]-3-methylpiperidine-2,6-dione C[C@@]1(CCC(=O)NC1=O)N1CC2=C(C=CC=C2OCC2=CC=C(CN3CCN(CC3)C3=C(F)C=C(F)C=C3)C=C2)C1=O Degrader C32H32F2N4O4 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1021/acs.jmedchem.9b01928 TPD-LF6F98 Mezigdomide Mezigdomide; 2259648-80-9; CC-92480; Mezigdomide [USAN]; LA88IH4O02; CC92480; MEZIGDOMIDE [INN]; 4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile; compound 4 [PMID: 32130004]; compound 4 (PMID: 32130004); BENZONITRILE, 4-(4-((4-(((2-((3S)-2,6-DIOXO-3-PIPERIDINYL)-2,3-DIHYDRO-1-OXO-1H-ISOINDOL-4-YL)OXY)METHYL)PHENYL)METHYL)-1-PIPERAZINYL)-3-FLUORO-; 4-(4-((4-(((2-((3S)-2,6-DIOXOPIPERIDIN-3-YL)-1-OXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL)OXY)METHYL)PHENYL)METHYL)PIPERAZIN-1-YL)-3-FLUOROBENZONITRILE; 4-(4-((4-((2-((3S)-2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl)oxymethyl)phenyl)methyl)piperazin-1-yl)-3-fluorobenzonitrile; 4-[4-({4-[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}oxy)methyl]phenyl}methyl)piperazin-1-yl]-3-fluorobenzonitrile; CELMoD CC-92480; Cereblon Modulator CC-92480; BMS986348; BMS 986348; BMS-986348; CC 92480; Cereblon E3 Ligase Modulation Drug CC-92480; Cereblon E3 Ubiquitin Ligase Modulating Agent CC-92480; UNII-LA88IH4O02; (S)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile; WHO 11455; (83S)-12-fluoro-71,82,86-trioxo-71,73-dihydro-6-oxa-7(4,2)-isoindola-2(1,4)-piperazina-8(3)-piperidina-1(1),4(1,4)-dibenzenaoctaphane-14-carbonitrile; Benzonitrile, 4-(4-((4-(((2-((3S)-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1Hisoindol-4-yl)oxy)methyl)phenyl)methyl)-1-piperazinyl)-3-fluoro-; QFC; Mezigdomide [WHO-DD]; Mezigdomide (JAN/USAN); orb1309864; CHEMBL4648616; SCHEMBL20608563; SCHEMBL29370160; SCHEMBL29520046; C32H30FN5O4; GTPL12718; GLXC-22274; BCP32805; EX-A5597; MFCD32263041; NSC853698; s8975; AKOS040732735; AT18067; NSC-853698; AC-38199; MS-30267; SY327515; HY-129395; CC 92480; CC92480; CS-0105182; D12000; (S)-4-[4-[4-[[[2-(2,6-Dioxo-3-piperidyl)-1-oxo-4-isoindolinyl]oxy]methyl]benzyl]-1-piperazinyl]-3-fluorobenzonitrile; 4-(4-((4-(((2-((3S)-2,6-DIOXOPIPERIDIN-3-YL)-1-OXO-2,3-DIHYDRO-1H-ISOINDOL-4- YL)OXY)METHYL)PHENYL)METHYL)PIPERAZIN-1-YL)-3-FLUOROBENZONITRILE; 4-[4-[[4-[[[2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy] methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro-Benzonitrile; 4-[4-[[4-[[2-[(3S)-2,6-dioxo-3-piperidyl]-1-oxo-isoindolin-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluoro-benzonitrile FC1=C(C=CC(=C1)C#N)N1CCN(CC2=CC=C(COC3=C4CN([C@H]5CCC(=O)NC5=O)C(=O)C4=CC=C3)C=C2)CC1 Degrader C32H30FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN 10.1021/acs.jmedchem.9b01928 TPD-EJ2HLI Paclitaxel paclitaxel; TAXOL; 33069-62-4; Taxol A; Yewtaxan; Genaxol; Plaxicel; Onxol; Paxene; Ebetaxel; Genetaxyl; Capxol; OncoGel; Cyclopax; Genexol; Intaxel; Mitotax; Pacliex; Paxceed; TaxAlbin; EmPAC; Onxal; Zisu; Taxus stent; Taxus Liberte; Padexol; EndoTAG 1; LEP-ETU; NSC-125973; Tocosol Paclitaxel; (-)-Paclitaxel; Nanoxel; Paclitaxol; Sindaxel; Taxus; Coroflex Please; Cypher select; Taxus Express; MBT 0206; NSC125973; Infinnium; DHP 107; DHP-107; Abraxane I.V. Suspension; BMS 181339-01; BMS-181339-01; P88XT4IS4D; 7 epi Taxol; NK 105; Paclitaxel (taxus canadensis); QW 8184; Liposome-entrapped paclitaxel easy-to-use; DTXSID9023413; CHEBI:45863; ABI-007 COMPONENT PACLITAXEL; IG 001; NK-105; 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; QW-8184; DTXCID603413; (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester; ABRAXANE COMPONENT PACLITAXEL; NSC 125973; NAB-PACLITAXEL COMPONENT PACLITAXEL; (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl benzoate; Bris Taxol; Taxol, Bris; [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate; Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-; paclitaxelum; ((1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo(11.3.1.03,10.04,7)heptadec-13-en-2-yl) benzoate; (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-(((2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl)oxy)-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo(11.3.1.0^(3,10).0^(4,7))heptadec-13-en-2-yl benzoate; PACITAXEL; Taxol 100; PACLITAXEL PACLITAXEL; L01CD01; Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,1-2alpha,12aalpha,12balpha))-; PACLITAXEL PROTEIN BOUND PARTICLES ALBUMIN BOUND; Paclitaxel protein-bound particles for injectable suspension (albumin-bound); (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-(((2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl)oxy)-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo(11.3.1.03,10.04,7)heptadec-13-en-2-yl benzoate; Tax-11-en-9-one, 5beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxy-, 4,10-diacetate 2-benzoate, 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; Abraxane; ABI-007; LipoPac; Genexol-PM; MFCD00869953; ABI 007; Paclitaxel (Taxol); HSDB 6839; DRG-0190; CHEMBL428647; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyl diacetate; nab-paclitaxel; MBT-0206; 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.; NCGC00164367-01; C47H51NO14; Anzatax; Cynviloq; Xorane; Taxol (Paclitaxel); (NAB)-Paclitaxel; SMR000857385; EndoTAG-1; SR-01000075350; UNII-P88XT4IS4D; Nanotaxel; Paclical; Pacligel; Paxoral; Paclitaxel?; CCRIS 8143; Paclitaxel [USAN:USP:INN:BAN]; Abraxane (TN); (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; [diacetoxy-[(2R,3S)-3-benzamido-2-hydroxy-3-phenyl-propanoyl]oxy-dihydroxy-tetramethyl-oxo-[?]yl] benzoate; Paclitaxel; 5beta,20-Epoxy-1,7beta-dihydroxy-9-oxotax-11-ene-2alpha,4,10beta,13alpha-tetrayl 4,10-diacetate 2-benzoate 13-[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate]; Taxol; Docetaxel Anhydrous Impurity F; Docetaxel Impurity F; CAS-33069-62-4; BMS-181339; Paclitaxel-SSMM-VIP; Paclitaxel (Standard); P-SSMM-VIP; PACLITAXEL [MI]; PACLITAXEL [INN]; PACLITAXEL [JAN]; Prestwick3_000155; PACLITAXEL [HSDB]; PACLITAXEL [USAN]; TAXOL (TN); PACLITAXEL [VANDF]; PACLITAXEL [MART.]; SCHEMBL3976; 3PPC5TL76P; Nova-12005; PACLITAXEL [USP-RS]; PACLITAXEL [WHO-DD]; Paclitaxel, Taxus brevifolia; BIDD:PXR0046; BSPBio_000290; KBioGR_002509; KBioSS_002517; Paclitaxel (JAN/USP/INN); MLS002154218; MLS002695976; OAS-PAC-100; PACLITAXEL [EMA EPAR]; BPBio1_000320; GTPL2770; MEGxp0_001940; orb1310120; Taxol (TN) (Bristol Meyers); PACLITAXEL [GREEN BOOK]; PACLITAXEL [ORANGE BOOK]; ACon1_002231; HY-B0015R; KBio2_002509; KBio2_005077; KBio2_007645; KBio3_002987; ANX-513; DHP-208; DTS-301; PACLITAXEL [EP MONOGRAPH]; PACLITAXEL [USP IMPURITY]; SDP-013; cMAP_000068; ORAXOL COMPONENT PACLITAXEL; HMS2090D07; HMS2095O12; HMS2231A16; HMS3712O12; PACLITAXEL [USP MONOGRAPH]; Abraxane (albumin-bound suspension); HY-B0015; MPI-5018; Tox21_112107; BDBM50001839; MSK000431; NSC745099; ABI 007 COMPONENT PACLITAXEL; AKOS007930675; AKOS015969673; AKOS025312303; CCG-220155; CS-1145; DB01229; FP10637; GS-6554; NSC-745099; NCGC00164367-02; NCGC00164367-03; NCGC00164367-04; NCGC00164367-05; NCGC00164367-10; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate, 12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; NCI60_000601; SY016928; Paclitaxel, from Taxus yannanensis, powder; 1ST000431; PACLITAXEL IMPURITY L [EP IMPURITY]; AB00513812; D00491; EN300-117275; M02242; N88686; AB00513812-02; AB00513812-03; Q423762; 7,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.; SR-01000075350-1; SR-01000075350-3; SR-01000075350-6; SR-01000075350-7; SR-01000075350-9; BRD-K62008436-001-03-1; BRD-K62008436-001-05-6; BRD-K62008436-001-22-1; Paclitaxel, from semisynthetic (from Taxus sp.), >=97%; Paclitaxel, European Pharmacopoeia (EP) Reference Standard; Paclitaxel, from Taxus brevifolia, >=95% (HPLC), powder; Paclitaxel, United States Pharmacopeia (USP) Reference Standard; 12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; Paclitaxel, Pharmaceutical Secondary Standard; Certified Reference Material; Paclitaxel natural for peak identification, European Pharmacopoeia (EP) Reference Standard; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro 4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano 5Hcyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate,; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-4,6,12b-Tris(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (alphaR,betaS)-beta-(benzoylamino)-alpha-hydroxybenzenepropanoate; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-(benzoylamino)-a-hydroxybenzenepropanoate; (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12; (2beta,5beta,7alpha,8alpha,10alpha,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; ,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester; ,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (alphaR,betaS)- (9CI); -cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aalpha,4beta,4abeta,6beta,9alpha(aR*,betaS*),11alpha,12alpha,12aalpha,12balpha]]-; [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetoxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenyl-propanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate; [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl]benzoate; 1203669-79-7; 4,7beta,10beta-tris(acetyloxy)-13alpha-[[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy]-1-hydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate; 4alpha,10beta-bis(acetyloxy)-13alpha-[(2S,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy]-1,7beta-dihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate; BENZENEPROPANOIC ACID, .BETA.-(BENZOYLAMINO)-.ALPHA.-HYDROXY-, (2AR,4S,4AS,6R,9S,11S,12S,12AR,12BS)-6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA(3,4)BENZ(1,2-B)OXET-9-YL ESTER, (.ALPHA.R,.BETA.S)-; Benzenepropanoic acid, 6,12b-bis(acetyl oxy)-12-(benzoyloxy)- 2a,3,4,4a,5,6,9,10,11,12,12a,12b,- dodecahydro-4,11- dihydroxy-4a,8,13,13-tetramethyl-5-oxo- 7,11-methano- 1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR- [2a.alpha.,4.beta.,4a.beta.,6.beta.,9.alpha.(alpha. R*,.beta.S*),11.alpha.,12.alpha.,12a.alpha.,12b.alpha.]]-; Benzenepropanoic acid, b-(benzoylamino)-.alpha.-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3, CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Stabilizer C47H51NO14 β tubulin;α tubulin P07437/Q71U36 . 10.3390/molecules25245986 TPD-AHE6L2 Tacrolimus tacrolimus; 104987-11-3; Fujimycin; Prograf; Tsukubaenolide; Tacrolimus anhydrous; Protopic; Anhydrous Tacrolimus; Advagraf; FK506; Modigraf; Protopy; Prograft; Tacrolimus, anhydrous; FK 506; Avagraf; Envarsus; FR-900506; Astagraf XL; Envarsus XR; FR 900506; Tacrolimus (anhydrous); Hecoria; (-)-FK 506; 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN; DTXSID5046354; FR900506; CHEBI:61049; Y5L2157C4J; DTXCID3026354; NSC-758659; CHEBI:61057; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone; 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-; Anhydrous, Tacrolimus; 8-DEETHYL-8-(BUT-3-ENYL)-ASCOMYCIN; tacrolimusum; Adoport; Capexion; Perixis; Vivadex; Tacrus; Tacni; NSC717865; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo(22.3.1.04,9)octacos-18-ene-2,3,10,16-tetrone; GlyTouCan:G51201CJ; TACROLIMUS 0.1%; Tacrolimus Ointment 0.1%; D11AH01; L04AD02; G51201CJ; tacrolimus extended-release capsules; TACROLIMUS 0.1% IN PSEUDOCATALASE; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-((1E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo(22.3.1.04,9)octacos-18-ene-2,3,10,16-tetrone; Hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone; 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-; Tacrolimus monohydrate; WM0HAQ4WNM; tacrolimus (fk506); Tacrolimus (INN); PROGRAPH; TACRO; Prograf (TN); Tacrolimus [USAN]; CHEMBL269732; K506; NCGC00163470-03; C44H69NO12; TACROLIMUS [INN]; FK-506 (Tacrolimus); MFCD11045918; Graceptor; MFCD00869853; Advagraf; Fujimycin; FK-506; FR 900506; SR-05000001879; Tacrolimus [USAN:INN]; Talymus; UNII-Y5L2157C4J; CCRIS 7124; HSDB 8195; L 679934; Tacrolimus (Standard); TACROLIMUS [MI]; SCHEMBL3088; TACROLIMUS [MART.]; TACROLIMUS [WHO-DD]; BSPBio_001279; CHEMBL66247; L-679934; GTPL6784; orb1306360; Tacrolimus - Bio-X trade mark; Tacrolimus in whole human blood; CHEBI:93221; HMS503O21; HMS1792O21; HMS1990O21; HMS2093M19; HMS3403O21; Pharmakon1600-01503968; ALBB-038671; EX-A1677; MSK10251; Tox21_112056; BDBM50030448; BDBM50079777; HB0289; Human Blood - Tacrolimus (incurred); HY-13756R; LMPK04000003; NSC758659; s5003; AKOS005145901; AC-1182; CCG-270494; CS-1507; DB00864; IDI1_001040; NCGC00163470-01; NCGC00163470-02; NCGC00163470-04; NCGC00163470-05; NCGC00163470-06; NCGC00163470-07; NCGC00163470-27; 1ST10251; BT164430; HY-13756; SBI-0052894.P002; CAS-104987-11-3; M2258; NS00008708; A11860; C01375; D08556; EN300-221601; AB01209746-01; AB01209746_03; Q411648; SR-05000001879-1; SR-05000001879-2; SR-05000001879-5; BRD-K35452788-001-02-1; BRD-K69608737-001-03-7; BRD-K69608737-001-08-6; BRD-K69608737-001-10-2; Z2242006187; [(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-allyl-1,14-dihydroxy-12-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone; (1R,9S,12S,13R,14S,17R,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-{1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0,4,9]octacos-18-ene-2,3,10,16-tetrone; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26AS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-HEXADECAHYDRO-5,19-DIHYDROXY-3-[(1E)-2-[(1R,3R,4R)-4-HYDROXY-3-METHOXYCYCLOHEXYL]-1-METHYLETHENYL]-14,16-DIMETHOXY-4,10,12,18-TETRAMETHYL-8-(2-PROPEN-1-YL)-15,19; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-e; (E)-(1R,9S,12S,13R,14R,21S,23S,24R,25S,27R)-17-Allyl-1,14-dihydroxy-12-[(E)-2-((3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0*4,9*]octacos-18-ene-2,3,10,16-tetraone; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycycl ohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; 4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-heptadecahydro-5,19-dihydroxy-3-; dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)- C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC Stabilizer C44H69NO12 FKBP12;calcineurin P62942/Q08209 . 10.1038/378641a0 TPD-L6PWY9 Sirolimus rapamycin; Sirolimus; 53123-88-9; (-)-Rapamycin; Rapamune; rapalimus; AY-22989; WY-090217; FYARRO; HYFTOR; sirolimusum; Npc-12g; Antibiotic AY 22989; RAPA; Rapammune; CHEBI:9168; SILA 9268A; W36ZG6FT64; L04AA10; SM-88 COMPONENT SIROLIMUS; NSC-226080; DTXSID5023582; AY 22989; NSC226080; NSC 226080; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; DTXCID503582; Wy 090217; (2S)-2-(((2R)-2-((2R,3R,4R,5S,6R)-3-acetamido-2-((((2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methoxy-hydroxy-phosphoryl)oxy-hydroxy-phosphoryl)oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl)oxypropanoyl)amino)propanoic acid; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-((2R)-1-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)propan-2-yl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido(2,1-c)(1,4)oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; S01XA23; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((2R)-1-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)propan-2-yl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; I2190A; I 2190A; AY 22 989; (1R,15R,16E,18R,19R,21R,23S,24Z,26E,28E,30S,35R)-1,18-dihydroxy-12-((2R)-1-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)propan-2-yl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; 1,18-dihydroxy-12-(1-(4-hydroxy-3-methoxycyclohexyl)propan-2-yl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,2; 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3R*(S*(1R*,3S*,4S*)),6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*))-; I-2190A; SIIA 9268A; Rapamycin (Sirolimus); Rapamycin (GMP); Rapamycin (GMP Like); MFCD00867594; DE-109; Rapamycin Immunosuppressant Drug; C51H79NO13; Rapamycin (>85%); (-)-Rapamycin; Sirolimus; Supralimus; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; Perceiva; Cypher; CCRIS 9024; HSDB 7284; 1fkb; 1pbk; NCGC00021305-05; Rapamycin/Sirolimus; LCP-Siro; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-(methyloxy)cyclohexyl]-1-methylethyl}-6,8,12,14,20,26-hexamethyl-10,21-bis(methyloxy)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(6H,31H)-pentone; RAP; Rapamycin (Standard); S1039; Rapamycin (Sirolimus)?; SIROLIMUS [INN]; SIROLIMUS [JAN]; RAPAMYCIN [MI]; Human Blood - Sirolimus; SIROLIMUS [HSDB]; SIROLIMUS [USAN]; SIROLIMUS [VANDF]; BiomolKI2_000084; SIROLIMUS [MART.]; SIROLIMUS [USP-RS]; SIROLIMUS [WHO-DD]; Rapamycin,Sirolimus,Rapamune; UNII-W36ZG6FT64; BIDD:PXR0165; SIROLIMUS [EMA EPAR]; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; MLS006010168; Sirolimus [USAN:INN:BAN]; Rapamycin - Bio-X trade mark; GTPL6031; orb1308282; SIROLIMUS [ORANGE BOOK]; BDBM36609; MS-R001; GLXC-06448; HMS2089A21; HMS3403F11; HMS3884C03; HY-10219GL; EX-A1044; RPM; AC-722; BDBM50064359; HB2779; HY-10219G; HY-10219R; STL570275; AKOS015850976; AKOS015961618; AE27685; CCG-100684; CS-0063; DB00877; NAB-RAPAMYCIN COMPONENT RAPAMYCIN; NCGC00021305-06; NCGC00021305-07; AS-11687; BR164324; HY-10219; SMR004701276; Fyarro (sirolimus albumin-bound particles); EVEROLIMUS IMPURITY A [EP IMPURITY]; UNM-0000358684; A-275; CS-0626126; CS-1010374; R0097; Rapamycin, VETRANAL(TM), analytical standard; EC 610-965-5; M02444; Q32089; BRD-K84937637-001-04-0; BRD-K84937637-001-06-5; BRD-K84937637-001-09-9; BRD-K84937637-001-11-5; BRD-K84937637-001-13-1; BRD-K89626439-001-01-0; Z2568665260; 24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypy; Rapamycin from Streptomyces hygroscopicus, >=95% (HPLC), powder; Rapamycin from Streptomyces hygroscopicus, Vetec(TM) reagent grade, >=95%; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34 aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hex adecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydro xy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy- 6,8,12,14,20,26-hexamethyl-23,27-ep; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-4,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-223,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(6H,31H)-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-ep; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-(methyloxy)cyclohexyl]-1-methylethyl}-6,8,12,14,20,26-hexamethyl-10,21-bis(methyloxy)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,; 1,18-Dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-ethyl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.0*4,9*]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone (Rapamycin) C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC Stabilizer C51H79NO13 mTOR1;FKBP12 P42345/P62942 . 10.1186/2001-1326-1-29 TPD-UKQ3MF Cyclosporin A cyclosporin A; Ciclosporin; cyclosporine; 59865-13-3; Sandimmune; Neoral; Cyclosporine A; Sandimmun; Ciclosporine; Neoplanta; Equoral; Gengraf; Ciclosporina; Ciclosporinum; Sang-35; Sandimmun Neoral; Zinograf ME; Consupren; Mitogard; Optimmune; Ciclosporin A; SangCyA; NeuroSTAT; Atopica; Restasis; S-Neoral; Cipol N; VEVYE; Antibiotic S 7481F1; Sang 35; Ikervis; Cyclosporine microemulsion; 83HN0GTJ6D; SDZ-OXL-400; CEQUA; VERKAZIA; CHEBI:4031; ANTIBIOTIC S-7481F1; DTXSID0020365; OL 27-400; NSC-290193; S 7481F1; DTXCID00365; OL-27-400; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; (R-(R*,R*-(E)))-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl); Cyclo(((E)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-2-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl); CsANeoral; NSC290193; CsA Neoral; CyA NOF; CyA-NOF; Cyclavance; Capimune; Capsorin; Deximune; Sporimune; Vanquoral; Atopica for Cats; Modulis for Cats; Modulis for Dogs; Restasis MultiDose; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-((E,1R,2R)-1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; (R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl); Cyclo[[(E)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl]-L-2-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]; Optimmune Ophthalmic; Cyclosporine Modified; OL 27400; CycloSPORINE, Modfied; OL 27 400; Cyclosporine/Chondroitin PF; cyclosporine ophthalmic solution; L04AD01; S01XA18; 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv.; Cyclosporine/Chondroitin Sulfate PF; 30-ethyl-33-(1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; 611-907-1; cyclo(-((2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-methylaminooct-6-enoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-); 30-ethyl-33-((E)-1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; Cyclosporin; Ramihyphin A; MFCD00274558; Ciclosporin [INN]; CSA; MLS001333756; C62H111N11O12; Sigmasporin Microoral; SDZ-OXL 400; Abrammune; Imusporin; Seciera; Vekacia; Papilock Mini; Arpimune ME; Sandimmune Neoral; Ciclosporina Germed; Cyclosporine; Ciclosporin; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; CYA; SMR000058578; Cicloral (antibiotic); Cyclosporine [USAN]; Debio088; Cyclosporine [USAN:USP]; UNII-83HN0GTJ6D; Ciclosporine [INN-French]; Ciclosporinum [INN-Latin]; Ciclosporina [INN-Spanish]; Sigmasporin; Cyclokat; Papilock; Pulminiq; Zyclorin; CicloMulsion; Ciclosporin; CCRIS 1590; Ciclosporin DT; Consupren S; Modusik-A; HSDB 6881; 1cyn; 2wfj; 4jjm; Cipol-N; NCGC00016890-01; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,2; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; DRG-0275; Prestwick_731; CAS-59865-13-3; NSC 290193; CsA & IFN.alpha.; 1c5f; 2z6w; Cyclosporine manufacturer; Prestwick2_000435; Prestwick3_000435; CICLOSPORIN [JAN]; Cyclosporin A (Standard); CHEMBL160; Sang-2000; CYCLOSPORINE [HSDB]; CYCLOSPORINE [IARC]; CYCLOSPORIN A [MI]; SCHEMBL4442; CICLOSPORIN [MART.]; CYCLOSPORINE [VANDF]; Nova-22007; BSPBio_000450; CICLOSPORIN [WHO-DD]; CICLOSPORIN [WHO-IP]; Cyclosporin A & IFN.alpha.; MLS000028376; MLS002153454; MLS002207033; CYCLOSPORINE [USP-RS]; BPBio1_000496; GTPL1024; orb1310145; Cyclosporine; Ciclosporin; Atopica; CHEBI:92233; HY-B0579R; ATH-002; CYCLOSPORINE [GREEN BOOK]; OLO-400; CB-01-09 MMX; CICLOSPORIN [EP MONOGRAPH]; CYCLOSPORINE [ORANGE BOOK]; Cyclosporine; Ciclosporin; Atopica; GLXC-04692; GLXC-06801; HMS1569G12; HMS2089A09; HMS2096G12; HMS2230M14; HMS3713G12; Cyclosporin A - Bio-X trade mark; CYCLOSPORINE [USP IMPURITY]; 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]; 30-Ethyl-33-(1-hydroxy-2-methyl-hex-4-enyl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31undecaaza-cyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone; 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl); EX-A4110; HY-B0579; MSK10250; CYCLOSPORINE [USP MONOGRAPH]; Tox21_110667; Tox21_301849; BDBM50022815; CICLOSPORINUM [WHO-IP LATIN]; DE-076; ST-603; Cyclosporin A, >=98.5% (TLC); AKOS015969287; AKOS015994720; Tox21_110667_1; CCG-208184; DB00091; FC20749; KS-1257; SDCCGSBI-0050230.P004; NCGC00093704-12; NCGC00164258-01; NCGC00164258-02; NCGC00164258-03; NCGC00255232-01; BC164336; BP-28432; Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl); OL-27400; SY012000; SBI-0050230.P003; C2408; M01532; Cyclosporin A, VETRANAL(TM), analytical standard; Q367700; SR-01000780563; SR-01000780563-3; BRD-K03222093-001-01-8; BRD-K13533483-001-03-0; Ciclosporin, European Pharmacopoeia (EP) Reference Standard; Cyclosporin A, from Tolypocladium inflatum, >=95% (HPLC), solid; Cyclosporine, United States Pharmacopeia (USP) Reference Standard; Ciclosporin for system suitability, European Pharmacopoeia (EP) Reference Standard; Cyclosporin A, from Tolypocladium inflatum, BioReagent, for molecular biology, >=95%; Cyclosporine, Pharmaceutical Secondary Standard; Certified Reference Material; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone; (R-(R*,R*-(E)))-CYCLIC(L-ALANYL-D-ALANYL-N-METHYL-L-LEUCYL-N-METHYL-L-LEUCYL-N-METHYL-L-VALYL-3-HYDROXY-N,4-DIMETHYL-L-2-AMINO-6-OCTENOYL-L-.ALPHA.-AMINOBUTYRYL-N-METHYLGLYCYL-N-METHYL-L-LEUCYL-L-VALYL-N-METHYL-L-LEUCYL); 104250-72-8; 30-Ethyl-33-((E)-1-hydroxy-2-methyl-hex-4-enyl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,28-octamethyl-1,4,7,10,13,16,19,22,25,28,31undecaaza-cyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C Stabilizer C62H111N11O12 CypA;PPP3CA P62937/Q08209 . 10.1073/pnas.192206699 TPD-NTC26C Dexrazoxane Dexrazoxane; 24584-09-6; ICRF-187; Dextrorazoxane; Dexrazoxano; Dexrazoxanum; ADR-529; ADR 529; Razoxane, d-; (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione; 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione; ICRF 187; Razoxane, (s)-; NSC-169780; (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane; NSC 169780; CHEBI:50223; NSC169780; 048L81261F; 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+)-; 4-[(2S)-1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione; ADR529; Hydrochloride, Dexrazoxane; ICRF187; 4-((2S)-2-(3,5-dioxopiperazin-1-yl)propyl)piperazine-2,6-dione; 4-((2S)-1-(3,5-dioxopiperazin-1-yl)propan-2-yl)piperazine-2,6-dione; 6-hydroxy-4-((2S)-2-(5-hydroxy-3-oxo-1,2,3,6-tetrahydropyrazin-1-yl)propyl)-2,3,4,5-tetrahydropyrazin-2-one; 6-hydroxy-4-[(2S)-2-(5-hydroxy-3-oxo-1,2,3,6-tetrahydropyrazin-1-yl)propyl]-2,3,4,5-tetrahydropyrazin-2-one; Razoxane, (S)-Isomer, Hydrochloride; Razoxane (+)-; Soluble ICRF (L-; V03AF02; 2,6-Piperazinedione, 4,4'propylenedi-,(P)-; 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)-; (+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione); 2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)-; 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-,(S)-; Zinecard; (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione); Dexrazoxanum [INN-Latin]; Dexrazoxano [INN-Spanish]; 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-; Dexrazone; Desrazoxane; MFCD00866449; DTXSID3040647; (+)-dexrazoxane; 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (S)-; (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; Razoxanum [INN-Latin]; Razoxana [INN-Spanish]; DTXCID1020647; 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione; CAS-24584-09-6; HSDB 7319; (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; 2,6-Piperazinedione, 4,4'-propylenedi-, (+)-; SR-01000883995; BRN 5759131; Soluble ICRF (L-isosomer); Dexrazoxane [USAN:INN:BAN]; Dexrazoxane?; CCRIS 9394; UNII-048L81261F; NCGC00164737-01; Dexrazoxane (Standard); DEXRAZOXANE [INN]; DEXRAZOXANE [JAN]; DEXRAZOXANE [HSDB]; DEXRAZOXANE [USAN]; DEXRAZOXANE [VANDF]; CHEMBL1738; DEXRAZOXANE [MART.]; SCHEMBL18400; DEXRAZOXANE [WHO-DD]; MLS006010158; BIDD:GT0068; Dexrazoxane (JAN/USAN/INN); DEXRAZOXANE [EMA EPAR]; 4,4'-(2S)-propane-1,2-diyldipiperazine-2,6-dione; GTPL7330; orb1306016; Dexrazoxane - Bio-X trade mark; Dexrazoxane, >=95% (HPLC); HY-B0581R; (S)-4,4'-(Propane-1,2-diyl)-bis(piperazine-2,6-dione); RAZOXANE (+)-FORM [MI]; HY-B0581; Tox21_112256; 2, 4,4'-propylenedi-, (+)-; BDBM50586360; s5651; AKOS015896392; Tox21_112256_1; (+)-1,5-dioxopiperazin-1-yl)propane; CCG-267131; DB00380; DS-1394; FD65001; NCGC00263544-01; NCGC00263544-02; BD164365; Dexrazoxane, analytical reference material; NCI60_001367; SMR002529680; (S)-(+)-1,5-dioxopiperazin-1-yl)propane; D4227; NS00073041; D03730; (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane; AB01273932-01; AB01273932-02; AB01273932_03; EN300-7356981; 2,4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-; Q524995; 2,4,4'-(1-methyl-1,2-ethanediyl)bis-, (S)-; SR-01000883995-1; SR-01000883995-2; SR-01000883995-5; BRD-K07265709-003-01-5; BRD-K07265709-003-03-1; BRD-K07265709-003-04-9; BRD-K07265709-003-05-6 C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2 Stabilizer C11H16N4O4 Topo IIβ Q02880 . 10.1073/pnas.1832879100 TPD-NZUYCP Golcadomide Golcadomide; 2379572-34-4; CC-99282; Golcadomide [USAN]; 29HLR8Z5BR; CC1007548; UNII-29HLR8Z5BR; CC99282; WHO 12305; (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 2-((3S)-2,6-dioxo-3-piperidinyl)-4-(((2-fluoro-4-((3-(4-morpholinyl)-1-azetidinyl)methyl)phenyl)methyl)amino)-; Golcadomida; golcadomide [INN]; Golcadomide [WHO-DD]; Golcadomide (USAN/INN); orb1686266; CHEMBL5095226; SCHEMBL21492854; SCHEMBL29363016; GTPL13021; EX-A6835; Cc 99282; AT41559; compound 1 [US20220324855]; DA-72007; MS-29895; HY-146237; CS-0530225; D12324; EN300-43359175; (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1- yl)methyl)benzyl)amino)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-[[[2-fluoro-4-[[3-(4- morpholinyl)-1-azetidinyl]methyl]phenyl]methyl]amino]-; 2-[(3S)-2,6-Dioxo-3-piperidinyl]-4-[[[2-fluoro-4-[[3-(4-morpholinyl)-1-azetidinyl]methyl]phenyl]methyl]amino]-1H-isoindole-1,3(2H)-dione; 2-[(3S)-2,6-dioxopiperidin-3-yl]-4-[[2-fluoro-4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methylamino]isoindole-1,3-dione; 2-[(3S)-2,6-dioxopiperidin-3-yl]-4-{[(2-fluoro-4-{[3-(morpholin-4-yl)azetidin-1-yl]methyl}phenyl)methyl]amino}-2,3-dihydro-1H-isoindole-1,3-dione C1CC(=O)NC(=O)[C@H]1N2C(=O)C3=C(C2=O)C(=CC=C3)NCC4=C(C=C(C=C4)CN5CC(C5)N6CCOCC6)F Degrader C28H30FN5O5 IKZF3;IKZF1 Q9UKT9/Q13422 CRBN 10.1039/d4md00870g TPD-X6EW9S WBC100 CID 134236278; 2095780-08-6; orb2279010; SCHEMBL19844914; GLXC-25222; [(1S,2S,4S,5S,7S,8R,9R,11S,13S)-1-methyl-17-oxo-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-8-yl] (2R)-2-amino-3-methylbutanoate; HY-145898; CS-0434502; (5bS,6aS,7aR,8R,8aS,9aS,9bS,10aS,10bS)-8a-Isopropyl-10b-methyl-3-oxo-1,2,3,5,5b,6,6a,8,8a,9a,9b,10b-dodecahydrotris(oxireno)[2',3':4b,5; 2'',3'':6,7; 2''',3''':8a,9]phenanthro[1,2-c]furan-8-yl D-valinate CC(C)[C@@H](N)C(=O)O[C@@H]1[C@@]2(C(C)C)O[C@H]2[C@@H]2O[C@]23[C@]12O[C@H]2C[C@H]1C2=C(CC[C@@]13C)C(=O)OC2 Degrader C25H33NO7 c-Myc P01106 CHIP 10.1002/advs.202104344 TPD-62HTNK AKOS021791654 Ethyl 1-[2-(3,4-dimethylphenyl)-4-[(3-fluorophenyl)methyl]-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonyl]piperidine-3-carboxylate; ETHYL 1-[2-(3,4-DIMETHYLPHENYL)-4-[(3-FLUOROPHENYL)METHYL]-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONYL]PIPERIDINE-3-CARBOXYLATE CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC=CC(F)=C3)C2=O)C1 Degrader C27H29FN4O5 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-56HW5M Ethyl 1-[2-(3,4-dimethylphenyl)-4-methyl-3,5-dioxo-1,2,4-triazine-6-carbonyl]piperidine-3-carboxylate SCHEMBL31221408 CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(C)C2=O)C1 Degrader C21H26N4O5 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-OO8LT9 39950798_C3 . CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC=CC(Cl)=C3)C2=O)C1 Degrader C27H29ClN4O5 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-ZGNVD3 SCHEMBL31221332 Ethyl 1-[2-(3,4-dimethylphenyl)-4-[(3-methylphenyl)methyl]-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonyl]piperidine-3-carboxylate; AKOS021791653; ETHYL 1-[2-(3,4-DIMETHYLPHENYL)-4-[(3-METHYLPHENYL)METHYL]-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONYL]PIPERIDINE-3-CARBOXYLATE CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC=CC(C)=C3)C2=O)C1 Degrader C28H32N4O5 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-HX877S 39950798_C5 . CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC=CC(C(F)(F)F)=C3)C2=O)C1 Degrader C28H29F3N4O5 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-WD0NU9 SCHEMBL31221335 Ethyl 1-[2-(3,4-dimethylphenyl)-4-[(3-methoxyphenyl)methyl]-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonyl]piperidine-3-carboxylate; AKOS021834968; ETHYL 1-[2-(3,4-DIMETHYLPHENYL)-4-[(3-METHOXYPHENYL)METHYL]-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONYL]PIPERIDINE-3-CARBOXYLATE CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC=CC(OC)=C3)C2=O)C1 Degrader C28H32N4O6 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-FEBI9X 39950798_C7 . CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC=CC(S(C)(=O)=O)=C3)C2=O)C1 Degrader C28H32N4O7S eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-2MPLUD 39950798_C8 . CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC=CC(C(C)C)=C3)C2=O)C1 Degrader C30H36N4O5 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-PJXLX6 SCHEMBL31221348 Ethyl 1-[2-(3,4-dimethylphenyl)-4-[(2-methylphenyl)methyl]-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonyl]piperidine-3-carboxylate; AKOS021791656; ETHYL 1-[2-(3,4-DIMETHYLPHENYL)-4-[(2-METHYLPHENYL)METHYL]-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONYL]PIPERIDINE-3-CARBOXYLATE CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC=CC=C3C)C2=O)C1 Degrader C28H32N4O5 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-ZWUNUF 39950798_C10 . CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC=C(C)C=C3)C2=O)C1 Degrader C28H32N4O5 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-8BA4P1 39950798_C11 . CCOC(=O)C1CCCN(C(=O)C2=NN(C3=CC=C(C)C(C)=C3)C(=O)N(CC3=CC(C)=CC(C)=C3)C2=O)C1 Degrader C29H34N4O5 eEF2K O00418 β-TrCP 10.1002/advs.202412985 TPD-F7IUYW Meisoindigo Meisoindigo; 97207-47-1; Methylisoindigotin; MFCD05988503; 1416052-36-2; (E)-1-methyl-[3,3'-biindolinylidene]-2,2'-dione; (3E)-1-methyl-3-(2-oxoindolin-3-ylidene)indolin-2-one; 3-(2-hydroxy-1-methylindol-3-yl)indol-2-one; 1-Methyl-[3,3'-biindolinylidene]-2,2'-dione; 92UIP6405R; 2H-Indol-2-one,3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-; N-Methylisoindigotin; Dian III; (E)-1,1'-dimethyl-[3,3'-biindolinylidene]-2,2'-dione; 2H-Indol-2-one, 3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-; 3-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one; Dian III; N-Methylisoindigotin; Natura-alpha; UNII-92UIP6405R; Meisoindigo?; Biindolene deriv.; NATURA-.ALPHA.; Oprea1_162254; MEISOINDIGO [WHO-DD]; SCHEMBL130855; CHEMBL607535; orb1307271; SCHEMBL13299737; SCHEMBL24186711; SCHEMBL29361307; SCHEMBL31189862; (3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one; EX-A361; TAK-114; DTXSID901025868; GLXC-02768; HMS1593P16; HMS5084O08; s5327; AKOS000360184; AKOS032947341; Dian III; N-Methylisoindigotin; Natura-; AC-8412; CCG-267207; FM30918; SB16469; 1-Methyl-3,3'-biindolenyl-2,2'-dione; AS-73456; HY-13680; SY235006; DB-127880; 1-Methyl-3,3-Biindole-2,2(1H,1H)Dione; M3082; SR-01000274672; 1-methyl-3-(2-oxoindolin-3-ylidene)indolin-2-one; SR-01000274672-1; BRD-K14529030-001-01-9; Q27271531; (E)-1-methyl-1H,1'H,2H,2'H-[3,3'-biindolylidene]-2,2'-dione; N-methylisoindigotin; 1-Methyl-3,3'-biindole-2,2'(1H,1'H)-dione; 1-methyl-3-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)-2,3-dihydro-1H-indol-2-one; 1-Methyl-[3,3 inverted exclamation mark -biindolinylidene]-2,2 inverted exclamation mark -dione CN1C(=O)/C(=C2/C(=O)NC3=CC=CC=C23)C2=CC=CC=C21 Degrader C17H12N2O2 PKMYT1 Q99640 TRIM25 10.1002/advs.202413676 TPD-CN5ZDZ 39575661_MG-Lin1 . CC1=NN=C2C=CC(C3=CC=CC(N(C)C(=O)/C=C/C4=CC=C(C(F)(F)F)C=C4)=C3)=NN12 Degrader C23H18F3N5O Lin28 Q9H9Z2 RNF126 10.1002/mabi.202400427 TPD-EUP9MH 39575661_MG-Lin2 . CC1=NN=C2C=CC(C3=CC=CC(N(C)C(=O)C4CCN(C(=O)/C=C/C5=CC=C(C(F)(F)F)C=C5)CC4)=C3)=NN12 Degrader C29H27F3N6O2 Lin28 Q9H9Z2 RNF126 10.1002/mabi.202400427 TPD-0028GD 39575661_MG-Lin3 . COC1=CC=C(C(=O)/C=C/C(=O)N2CCC(C(=O)N(C)C3=CC=CC(C4=NN5C(C)=NN=C5C=C4)=C3)CC2)C=C1 Degrader C30H30N6O4 Lin28 Q9H9Z2 RNF126 10.1002/mabi.202400427 TPD-VURUTF 39309493_LXH-3-71 . C=C1CC2(C)C(CCC3[C@@H]2CC=C2[C@@H]4CC(C)(C)CC[C@]4(C(=O)NCCNC(=O)NC4=CC=C(OC)C=C4)CC[C@]23C)[C@@H](C)C1=O Degrader C39H55N3O4 PHGDH O43175 DDB1 10.1016/j.apsb.2024.06.001 TPD-ZNP52H (R)-FL-118 (4R)-4-Ethyl-4-hydroxy-8,9-methylenedioxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 151636-76-9; FL118; (R)-FL118; CHEMBL2115024; (4R)-4-Ethyl-4-hydroxy-8,9-methylenedioxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (5R)-5-Ethyl-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(13),2,4(9),14,16,21,23-heptaene-6,10-dione; (R)-7-ethyl-7-hydroxy-7H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(10H,13H)-dione; orb1700596; SCHEMBL20286453; SCHEMBL29429769; BDBM50407002; AKOS030528615; AC-33644; HY-15792; MS-26553; CS-0009145; (7R)-7-Ethyl-7-hydroxy-7,13-dihydro-2H,10H-1,3-dioxolano[4,5-g]pyrano[3',4'-6,7]indolizino[1,2-b]quinoline-8,11-dione; (R)-7-ethyl-7-hydroxy-10,13-dihydro-11H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H)-dione CC[C@]1(O)C(=O)OCC2=C1C=C1C3=NC4=CC5=C(C=C4C=C3CN1C2=O)OCO5 Degrader C21H16N2O6 DDX5 P17844 . 10.1002/ctm2.881 TPD-2MW3S7 39681169_dALK-2 . COC1=CC=C(C(=O)/C=C/C(=O)N2CCC(N3C=C(C4=CN=C(N)C(O[C@H](C)C5=C(Cl)C=CC(F)=C5Cl)=C4)C=N3)CC2)C=C1 Degrader C32H30Cl2FN5O4 ALK Q9UM73 RNF126 10.1016/j.bmcl.2024.130075 TPD-SD5WFD 39681169_dALK-1 . COC1=CC=C(C(=O)/C=C/C(=O)N2CCC(C3=CC(OC(C)C)=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(=O)C(C)C)=N4)C=C3C)CC2)C=C1 Degrader C39H44ClN5O6S ALK Q9UM73 RNF126 10.1016/j.bmcl.2024.130075 TPD-R0JRK1 39681169_dALK-10 . CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)/C=C/C(=O)C4=CC=C(OC)C=C4)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2N1 Degrader C41H43N5O4 ALK Q9UM73 RNF126 10.1016/j.bmcl.2024.130075 TPD-XMCN09 dALK-3 (E)-1-[4-[1-[4-[[5-chloro-4-(2-dimethylphosphorylanilino)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperidin-4-yl]piperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione; orb2945569; HY-170592 COC1=CC=C(C(=O)/C=C/C(=O)N2CCN(C3CCN(C4=CC=C(NC5=NC=C(Cl)C(NC6=CC=CC=C6P(C)(C)=O)=N5)C(OC)=C4)CC3)CC2)C=C1 Degrader C39H45ClN7O5P ALK Q9UM73 RNF126 10.1016/j.bmcl.2024.130075 TPD-5CITR9 SCHEMBL26106012 3-[3-oxo-6-[4-(pyrrolidin-1-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30612028 "O=C1CCC(N2CC3=CC(C4=CC(CN5CCCC5)=C5C=CNC5=N4)=CC=C3C2=O)C(=O)N1 " Degrader C25H25N5O3 IKZF2;CK1α;SALL4 Q9UKS7/P48729/Q9UJQ4 CRBN 10.1016/j.bmcl.2025.130263 TPD-6L8NTP 39488207_(S)-ACE-OH (1S)-1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanol C[C@H](O)C1=CC=C2SC3=CC=CC=C3N(CCCN(C)C)C2=C1 Degrader C19H24N2OS GLE1;SMPD4;NUP35 A0A804HI94/Q9NXE4/Q8NFH5 TRIM21 10.1016/j.cell.2024.10.015 TPD-0QV1MT orb2802127 4-(Cyclopropylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL17873781; 1957235-62-9 O=C1CCC(N2C(=O)C3=CC=CC(NC4CC4)=C3C2=O)C(=O)N1 Degrader C16H15N3O4 FIZ1 Q96SL8 CRBN 10.1016/j.chembiol.2024.10.007 TPD-J7AKTX 39721086_9d . COC1=NC=C(C2=CC=C3NC(=O)C4=C(C3=C2)N(C2=CC(C(F)(F)F)=C(N3CCN(C(=O)/C=C/C(=O)C5=CC=CC=C5)CC3)C=C2)N=N4)C=C1 Degrader C36H28F3N7O4 RIOK2 Q9BVS4 RNF126 10.1016/j.ejmech.2024.117166 TPD-AMCV7M 39721086_9e . COC1=NC=C(C2=CC=C3NC(=O)C4=C(C3=C2)N(C2=CC(C(F)(F)F)=C(N3CCN(C(=O)C5=CCCC5)CC3)C=C2)N=N4)C=C1 Degrader C32H28F3N7O3 RIOK2 Q9BVS4 RNF126 10.1016/j.ejmech.2024.117166 TPD-S22I9T Benzbromarone benzbromarone; 3562-84-3; Benzbromaron; MJ 10061; Benzbromaronum; Uroleap; Methanone, (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-; 3,5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; Benzpromarone; 2-Ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran; L-2214; NSC-85433; Benzbromarona; 4POG0RL69O; CHEBI:3023; DTXSID4022652; MJ-10061; DTXCID702652; AL, Benzbromaron; Benzbromaron ratiopharm; 2,6-dibromo-4-((2-ethyl-1-benzofuran-3-yl)carbonyl)phenol; 2,6-dibromo-4-[(2-ethyl-1-benzofuran-3-yl)carbonyl]phenol; 3,5-Dibromo-4-hydroxyphenyl 2-ethylbenzo(b)furan-3-yl ketone; 3,5-dibromo-4-hydroxyphenyl 2-ethylbenzo[b]furan-3-yl ketone; Narcaricin mite; M04AB03; 222-630-7; Desuric; Urinorm; Normurat; Uricovac; Minuric; Exurate; Hipurik; Azubromaron; Narcaricin; L 2214-Labaz; Uroleap (TN); L 2214; MFCD00078962; NSC 85433; 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran; (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone; NSC85433; KETONE, 3,5-DIBROMO-4-HYDROXYPHENYL 2-ETHYL-3-BENZOFURANYL; (3,5-Dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone; (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone; CPD000058310; Benzofuran, 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-; MLS000028522; MLS000737128; CHEMBL388590; Besuric; Harolan; NCGC00013895-08; Benzobromarona; 3, 5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; 3-[3,5-DIBROMO-4-HYDROXYBENZOYL]-2-ETHYLBENZOFURAN; SMR000058310; CAS-3562-84-3; (3,5-dibromo-4-hydroxy-phenyl)-(2-ethylbenzofuran-3-yl)methanone; C17H12Br2O3; Benzbromaronum [INN-Latin]; Benzobromarona [INN-Spanish]; Benzbromarone [USAN:INN:BAN]; L2214-Labaz; Max-uric; [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone; L2214; SR-01000003082; EINECS 222-630-7; UNII-4POG0RL69O; BRN 0273668; (2-Ethyl-3-benzofuranyl)-(3,5-dibrom-4-hydroxyphenyl)keton; (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)methanone; ML054; NCI85433; R75; Prestwick_709; Benzbromarone(USAN); 3,5-Dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl Ketone; Benzbromarone (Standard); Opera_ID_1282; Prestwick0_000370; Prestwick1_000370; Prestwick2_000370; Prestwick3_000370; Benzbromarone 100 microg/mL in Acetonitrile; BENZBROMARONE [MI]; BENZBROMARONE [INN]; BENZBROMARONE [JAN]; cid_2333; NCIStruc1_001498; NCIStruc2_001681; BENZBROMARONE [USAN]; Oprea1_140235; SCHEMBL48993; BSPBio_000499; MLS001074105; MLS001424143; BENZBROMARONE [MART.]; 2-Ethyl-3-(3,5-dibromo-4-hydroxybenzoyl)benzofuran; SPBio_002420; BENZBROMARONE [WHO-DD]; BPBio1_000549; orb1309157; SCHEMBL29361528; HY-B1135R; Benzbromarone, analytical standard; Benzbromarone (JP18/USAN/INN); HMS1569I21; HMS2052K05; HMS2093J04; HMS2096I21; HMS2230D20; HMS3394K05; HMS3652H15; HMS3713I21; HMS3744G15; HMS5082D14; Pharmakon1600-01505971; (3,5-Dibromo-4-hydroxyphenyl)-(2-ethylbenzofuran-3-yl)methanone; BCP07515; EX-A1131; HY-B1135; BENZBROMARONE [EP MONOGRAPH]; Tox21_110041; BDBM50158460; CCG-37198; MSK000451; NCGC00013895; NSC759281; s4221; SBB057006; Benzbromarone 1.0 mg/ml in Methanol; AKOS015895856; Tox21_110041_1; AC-6162; CS-4740; DB12319; FD18180; KS-1292; NC00334; NSC-759281; NCGC00013895-01; NCGC00013895-02; NCGC00013895-03; NCGC00013895-04; NCGC00013895-05; NCGC00013895-06; NCGC00013895-07; NCGC00013895-09; NCGC00013895-11; NCGC00013895-13; NCGC00022066-04; NCI60_041884; SY018127; SBI-0055383.P002; B4099; NS00001815; ST50993903; SW196858-4; UNM000001228903; D01056; Q410435; SR-01000003082-5; SR-01000003082-6; BRD-K11717138-001-03-0; BRD-K11717138-001-16-2; BRD-K11717138-001-29-5; BRD-K11717138-001-30-3; Ketone,5-dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl; Benzbromarone, certified reference material, TraceCERT(R); Benzbromarone, European Pharmacopoeia (EP) Reference Standard; Methanone,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-; (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone #; Methanone, (3, 5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-; benzbromarone; bzm; 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran; (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone; Benzbromarone; 3,5-Dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl ketone; 2-Ethyl-3-(3,5-dibromo-4-hydroxybenzoyl)benzofuran CCC1=C(C(=O)C2=CC(Br)=C(O)C(Br)=C2)C2=CC=CC=C2O1 Degrader C17H12Br2O3 HSP47 P50454 . 10.1016/j.jid.2023.09.279 TPD-Q2G3LX 37084663_pelitinib . CCOC1=CC2=NC=C(C#N)C(NC3=CC=C(F)C(Cl)=C3)=C2C=C1NC(=O)/C=C/CN(C)C Degrader C24H23ClFN5O2 PRDX4 Q13162 UBE2 10.1016/j.jpba.2023.115398 TPD-BBTF1C 10.1016/j.xcrp.2024.101960_C7 . N#CCC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C15H11N3O4 BCL-2;ZNF-90 P10415/Q03938 CRBN 10.1016/j.xcrp.2024.101960 TPD-B48CEO Thalidomide 5-fluoride 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-2,3-dihydro-1H-isoindole-1,3-dione; 831-704-3; 835616-61-0; 2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-; 2-(2,6-DIOXOPIPERIDIN-3-YL)-5-FLUOROISOINDOLE-1,3-DIONE; MFCD30188075; Thalidomide-5'-fluoride; LCWG009; orb1298135; SCHEMBL13284601; SCHEMBL26641673; SCHEMBL26641865; SCHEMBL30437394; DTXSID50744063; 2-(2,6-dioxo-3-piperidyl)-5-fluoro-isoindoline-1,3-dione; BDBM511657; 2832711-51-8; EX-A3914; KIB61661; US11059801, Compound D-24; AKOS037653474; HY-W087383; AC-37438; BP-27966; DA-78380; SY246564; CS-0127616; W19652; EN300-7434256; Z2508928182; 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1,3-isoindolinedione; 2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-1H-isoindole-1,3(2H)-dione; 2-[(3S)-2,6-dioxo-3-piperidyl]-5-fluoro-isoindoline-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(F)C=C3C2=O)C(=O)N1 Degrader C13H9FN2O4 BCL-2;ZNF-90 P10415/Q03938 CRBN 10.1016/j.xcrp.2024.101960 TPD-FZGK78 E3 ligase Ligand 4 2-(2,6-Dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione; 835616-60-9; 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione; Thalidomide 4-fluoride; Thalidomide fluoride; 2-(2,6-Dioxo-piperidin-3-yl)-4-fluoroisoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-fluoro-; MFCD11840666; 4-Fluoro-thalidomide; TC E3 5032; 2-(2,6-DIOXOPIPERIDIN-3-YL)-4-FLUOROISOINDOLE-1,3-DIONE; 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione; 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-2,3-dihydro-1H-isoindole-1,3-dione; C13H9FN2O4; Cereblon ligand 4; E3 ligase Ligand 4; 2-(2,6-dioxo-3-piperidyl)-4-fluoro-isoindoline-1,3-dione; TC-E3 5032; E3 Ligase Ligand-4; LCZC1115; orb1299536; SCHEMBL3537840; SCHEMBL29842915; DTXSID20474502; CRAUTELYXAAAPW-UHFFFAOYSA-N; BDBM511648; GLXC-15347; BCP30586; CS-B1597; EX-A3870; US11059801, Compound D-14; AKOS037435231; E3 ligase Ligand 4(TC-E3 5032)?; BP-24430; FD163674; HY-41547; SY248864; DS-022387; N14952; EN300-6477708; F0001-6242; Z2195271007; 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1,3-isoindolinedione; TC E3 5032; 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione O=C1CCC(N2C(=O)C3=CC=CC(F)=C3C2=O)C(=O)N1 Degrader C13H9FN2O4 BCL-2;ZNF-90 P10415/Q03938 CRBN 10.1016/j.xcrp.2024.101960 TPD-7RWUY0 37252349_DD-1-073 . COC1=CC=C(C(=O)/C=C/C(=O)N2CCN(C(=O)C3=CC=C(NC(=O)CCCCCCC(=O)NO)C=C3)CC2)C=C1 Degrader C30H36N4O7 HDAC1;HDAC3 Q13547/O15379 RNF126 10.1021/acscentsci.2c01317 TPD-1PH4BF CDK4 degrader 1 CDK4 degrader 1; CS-1096690 C=CS(=O)(=O)N1CCN(C2=CC=C(NC3=NC=C4C=C(C(=O)N(C)C)N(C5CCCC5)C4=N3)N=C2)CC1 Degrader C25H32N8O3S CDK4;CDK6 P11802/Q00534 DCAF16 10.1021/acscentsci.4c00286 TPD-R12A0Q PRLX-93936 3-(2-Ethoxyphenyl)-2-(piperazin-1-ylmethyl)quinazolin-4-one; 903499-49-0; 3-(2-ethoxyphenyl)-2-(1-piperazinylmethyl)-4(3H)-quinazolinone; 3-(2-ethoxyphenyl)-2-(piperazin-1-ylmethyl)quinazolin-4-one; 3-(2-ethoxyphenyl)-2-(piperazin-1-ylmethyl)quinazolin-4(3h)-one; CHEMBL1836238; orb1693766; SCHEMBL4406852; SCHEMBL29634183; PRLX93936; BDBM50354121; GS4107; AKOS037653306; E6999JX933; DB-377828; HY-119264; F94277; 4(3H)-Quinazolinone, 3-(2-ethoxyphenyl)-2-(1-piperazinylmethyl)- CCOC1=CC=CC=C1N1C(CN2CCNCC2)=NC2=CC=CC=C2C1=O Degrader C21H24N4O2 NUP214;NUP35;NUP155;SMPD4;GLE1 P35658/Q8NFH5/O75694/Q9NXE4/A0A804HI94 TRIM21 10.1021/acschembio.5c00036 TPD-B97LPU Bms-214662 BMS-214662; 195987-41-8; BMS 214662; BMS214662; L2U9GFD244; 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine; (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile; CHEBI:167655; DTXSID20173260; (3R)-1-(3H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrile; DTXCID5095751; FTI BMS 214662; NSC710086; (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile; (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrile; (R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile; CHEMBL351706; 3-BENZYL-1-(1H-IMIDAZOL-4-YLMETHYL)-4-(THIEN-2-YLSULFONYL)-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE; (4R)-4-benzyl-2-(3H-imidazol-4-ylmethyl)-5-thiophen-2-ylsulfonyl-2,5-diazabicyclo[5.4.0]undeca-8,10,12-triene-9-carbonitrile; UNII-L2U9GFD244; OLCWFLWEHWLBTO-HSZRJFAPSA-N; BMV; SCHEMBL94663; SCHEMBL134853; GTPL8026; orb1710238; SCHEMBL29454371; BCP24307; VHA98741; BDBM50092365; BMS 214662 [WHO-DD]; AKOS040732621; CS-6471; DB12234; HY-16111; MS-29107; NS00069582; G13661; Q27075336; (3R)-3-benzyl-1-(1H-imidazol-4-ylmethyl)-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile; (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile; (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienyisulfonyl)-1H-1,4-benzodiazepine-7-carbonitile; (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile; BMS 214662; (R)-3-Benzyl-1-(1H-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile; (R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile; (r)-7-cyano-2,3,4,5-tetrahydro-1-(1h-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1h-1,4-benzodiazepine; 1H-1,4-BENZODIAZEPINE-7-CARBONITRILE, 2,3,4,5-TETRAHYDRO-1-(1H-IMIDAZOL-4-YLMETHYL)-3-(PHENYLMETHYL)-4-(2-THIENYLSULFONYL)-, (3R)-; 1H-1,4-BENZODIAZEPINE-7-CARBONITRILE, 2,3,4,5-TETRAHYDRO-1-(1H-IMIDAZOL-4-YLMETHYL)-3-(PHENYLMETHYL)-4-(2-THIENYLSULFONYL)-, (R)-; 3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile N#CC1=CC=C2C(=C1)CN(S(=O)(=O)C1=CC=CS1)[C@H](CC1=CC=CC=C1)CN2CC1=CN=CN1 Degrader C25H23N5O2S2 NUP214;NUP35;NUP155;SMPD4;GLE1 P35658/Q8NFH5/O75694/Q9NXE4/A0A804HI94 TRIM21 10.1021/acschembio.5c00036 TPD-9KVT1A 37816014_7-13 . CC(=O)NCCN(C1=NC(N2CC(OC3=NC=CS3)C2)=NC(N2CC3C(CCOC4=CC(C5=C(C)N=CS5)=CC=C4CNC(=O)[C@@H]4C[C@@H](O)CN4C(=O)[C@@H](NC(=O)C4(F)CC4)C(C)(C)C)C3C2)=N1)C(C)C Degrader C49H65FN12O7S2 BRD9 Q9H8M2 VHL 10.1021/jacs.3c08307 TPD-XBU9VA SCHEMBL22737366 4-Amino-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione; MFCD35449866; SY482489; 4-Amino-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione; 2713422-01-4 NC1=CC(F)=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C13H10FN3O4 IKZF1;SALL4;PLZF Q13422/Q9UJQ4/Q05516 CRBN 10.1038/s41467-023-40385-9 TPD-5PFAQA 37596276_NE-O10 . O=C1CCC(N2C(=O)C3=CC=C(O)C(F)=C3C2=O)C(=O)N1 Degrader C13H9FN2O5 SALL4;PLZF Q9UJQ4/Q05516 CRBN 10.1038/s41467-023-40385-9 TPD-2P08EK 38110475_25 4-(4-Acetylpiperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione CC(=O)N1CCN(C2=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=CC=C2)CC1 Degrader C19H20N4O5 ZNF276;ZFP91;E4F1;IKZF3Q147E;SALL4;ZNF517 Q8N554/Q96JP5/Q66K89/Q9UKT9/Q9UJQ4/Q6ZMY9 CRBN 10.1038/s41557-023-01379-8 TPD-LJUY8G 38110475_39 5-(4-Acetylpiperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione CC(=O)N1CCN(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)CC1 Degrader C19H20N4O5 ZNF276 Q8N554 CRBN 10.1038/s41557-023-01379-8 TPD-9TO6EB CZ0A0LDL6A Acetamide, N-(2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-; UNII-CZ0A0LDL6A; 444289-17-2; M18(CC-4067); Acetamide, N-(2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-; N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide; N-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]acetamide; N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide; SCHEMBL2384927; SCHEMBL20548448; SCHEMBL29569032; BDBM511640; US11059801, Compound D-3; N-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]acetamide; SY311357; Q27275901; N-(2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-acetamide CC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C15H13N3O5 ZNF582;ZKSC5 Q96NG8/Q9Y2L8 CRBN 10.1038/s41557-023-01379-8 TPD-YV7Y15 SCHEMBL17884408 N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)acetamide; BDBM511642; US11059801, Compound D-5; N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)acetamide; N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-5-yl]acetamide; 1957235-50-5 CC(=O)NC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C15H13N3O5 ZNF787;ZNF517;ZNF654;ZNF582 Q6DD87/Q6ZMY9/Q8IZM8/Q96NG8 CRBN 10.1038/s41557-023-01379-8 TPD-TE5FLF N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pivalamide N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pivalamide CC(C)(C)C(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C18H19N3O5 ZNF653;ZNF582 Q96CK0/Q96NG8 CRBN 10.1038/s41557-023-01379-8 TPD-9K730T N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pivalamide N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pivalamide CC(C)(C)C(=O)NC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C18H19N3O5 ZNF787;ZNF654 Q6DD87/Q8IZM8 CRBN 10.1038/s41557-023-01379-8 TPD-HZD7QX SCHEMBL26815168 Tert-butyl 6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate; tert-butyl 6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate CC(C)(C)OC(=O)N1CC2(C1)CN(C1=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=CC=C1)C2 Degrader C23H26N4O6 ZNF276;ZNF653;E4F1 Q8N554/Q96CK0/Q66K89 CRBN 10.1038/s41557-023-01379-8 TPD-7H9OT0 SCHEMBL20120648 Tert-butyl 6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate; SCHEMBL29773870; tert-butyl 6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate CC(C)(C)OC(=O)N1CC2(C1)CN(C1=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C1)C2 Degrader C23H26N4O6 ZNF653 Q96CK0 CRBN 10.1038/s41557-023-01379-8 TPD-45HEUU SCHEMBL22835527 Tert-butyl 9-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,9-diazaspiro[5.5]undecane-3-carboxylate; tert-butyl 9-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,9-diazaspiro[5.5]undecane-3-carboxylate CC(C)(C)OC(=O)N1CCC2(CC1)CCN(C1=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=CC=C1)CC2 Degrader C27H34N4O6 PATZ1;ZNF582;ZKSC5;IKZF3 Q9HBE1/Q96NG8/Q9Y2L8/Q9UKT9 CRBN 10.1038/s41557-023-01379-8 TPD-47C3FW ARV-825 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide; 1818885-28-7; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide; MFCD29472237; CHEMBL4226052; 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]acetamide; orb573167; ARV825; orb1146582; orb1301793; SCHEMBL17162093; SCHEMBL29380962; CHEBI:230507; RWLOGRLTDKDANT-TYIYNAFKSA-N; ARV825; ARV 825; BCP19950; EX-A2379; BDBM50512415; NSC789043; s8297; AKOS030526673; CS-4776; NSC-789043; NCGC00483927-01; NCGC00483927-04; AC-35491; BP-27847; DA-71053; HY-16954; SY388247; BRD-A00047421-001-01-7; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-ylamino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide; 2-((S,Z)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-ylamino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide; 2-[(S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]acetamide CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1 Degrader C46H47ClN8O9S ZNF276;ZNF653;ZNF827;ZNF654 Q8N554/Q96CK0/Q17R98/Q8IZM8 CRBN 10.1038/s41557-023-01379-8 TPD-FGPNJT 1883863-52-2 2-((9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo(8.3.0.0,2,6)trideca-2(6),4,7,10,12-pentaen-9-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino)ethyl)acetamide; 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)acetamide; 2-((9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo(8.3.0.0,2,6)trideca-2(6),4,7,10,12-pentaen-9-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino)ethyl)acetamide; 963-550-9; dBET57; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide; 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]acetamide; dBET57?; orb1301789; CHEMBL5180012; SCHEMBL17553391; SCHEMBL29474857; TQP1624; GLXC-21608; EX-A3901; AKOS040758749; AC-36716; BP-40459; DA-52346; HY-123844; CS-0086541; D80431; EN300-24496085; Z4185702530 CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1 Degrader C34H31ClN8O5S ZNF276;ZNF653;ZNF827;ZFP91;E4F1;ZNF787;ZNF517;ZNF654;PATZ1;ZNF582 Q8N554/Q96CK0/Q17R98/Q96JP5/Q66K89/Q6DD87/Q6ZMY9/Q8IZM8/Q9HBE1/Q96NG8 CRBN 10.1038/s41557-023-01379-8 TPD-SMRVV4 38110475_dALK-7 5-(4-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)acetyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione CC1=C(C2CCN(CC(=O)N3CCN(C4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)CC3)CC2)C=C(OC(C)C)C(NC2=NC(NC3=CC=CC=C3S(=O)(=O)C(C)C)=C(Cl)C=N2)=C1 Degrader C47H54ClN9O8S ZNF827;ZNF787 Q17R98/Q6DD87 CRBN 10.1038/s41557-023-01379-8 TPD-V1YQZ7 N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)isoxazole-5-carboxamide N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)isoxazole-5-carboxamide O=C1CCC(N2C(=O)C3=C(C2=O)C(NC(=O)C2=CC=NO2)=CC=C3)C(=O)N1 Degrader C17H12N4O6 ZNF276;ZNF653;ZNF827;ZFP91;E4F1 Q8N554/Q96CK0/Q17R98/Q96JP5/Q66K89 CRBN 10.1038/s41557-023-01379-8 TPD-3EVKH2 SCHEMBL501896 N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)nicotinamide; SCHEMBL30001562; UZKKKDIDZKECMB-UHFFFAOYSA-N; N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)nicotinamide; n-[2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl]-3-pyridylcarboxamide O=C1CCC(N2C(=O)C3=C(C2=O)C(NC(=O)C2=CN=CC=C2)=CC=C3)C(=O)N1 Degrader C19H14N4O5 ZNF276;ZNF653;ZNF827;ZNF517;ZNF654 Q8N554/Q96CK0/Q17R98/Q6ZMY9/Q8IZM8 CRBN 10.1038/s41557-023-01379-8 TPD-RYIOKN N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pyrazine-2-carboxamide N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pyrazine-2-carboxamide O=C1CCC(N2C(=O)C3=C(C2=O)C(NC(=O)C2=NC=CN=C2)=CC=C3)C(=O)N1 Degrader C18H13N5O5 ZNF276;ZNF653;ZNF827;ZNF787;ZNF517;ZNF654;ZFP91;E4F1 Q8N554/Q96CK0/Q17R98/Q6DD87/Q6ZMY9/Q8IZM8/Q96JP5/Q66K89 CRBN 10.1038/s41557-023-01379-8 TPD-FR4QGN SCHEMBL2382531 N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)cyclopropanecarboxamide; SCHEMBL29794467; ZNSIEKYJZZEJNA-UHFFFAOYSA-N; N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)cyclopropanecarboxamide; cyclopropanecarboxylic acid [2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-amide O=C1CCC(N2C(=O)C3=C(C2=O)C(NC(=O)C2CC2)=CC=C3)C(=O)N1 Degrader C17H15N3O5 ZNF276;ZNF582;ZKSC5 Q8N554/Q96NG8/Q9Y2L8 CRBN 10.1038/s41557-023-01379-8 TPD-NR4OG1 N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)cyclobutanecarboxamide N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)cyclobutanecarboxamide O=C1CCC(N2C(=O)C3=C(C2=O)C(NC(=O)C2CCC2)=CC=C3)C(=O)N1 Degrader C18H17N3O5 ZNF276;ZNF653;ZNF827;ZNF517;ZNF654 Q8N554/Q96CK0/Q17R98/Q6ZMY9/Q8IZM8 CRBN 10.1038/s41557-023-01379-8 TPD-D68KAR N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pyrazine-2-carboxamide N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pyrazine-2-carboxamide O=C1CCC(N2C(=O)C3=C(C=C(NC(=O)C4=NC=CN=C4)C=C3)C2=O)C(=O)N1 Degrader C18H13N5O5 ZNF787;ZNF517;ZNF654 Q6DD87/Q6ZMY9/Q8IZM8 CRBN 10.1038/s41557-023-01379-8 TPD-XKU20O SCHEMBL29794480 N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)cyclopropanecarboxamide; N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)cyclopropanecarboxamide O=C1CCC(N2C(=O)C3=C(C=C(NC(=O)C4CC4)C=C3)C2=O)C(=O)N1 Degrader C17H15N3O5 ZNF787;ZNF517;ZNF654;ZKSC5 Q6DD87/Q6ZMY9/Q8IZM8/Q9Y2L8 CRBN 10.1038/s41557-023-01379-8 TPD-P747UX N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)cyclobutanecarboxamide N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)cyclobutanecarboxamide O=C1CCC(N2C(=O)C3=C(C=C(NC(=O)C4CCC4)C=C3)C2=O)C(=O)N1 Degrader C18H17N3O5 ZNF582;ZKSC5 Q96NG8/Q9Y2L8 CRBN 10.1038/s41557-023-01379-8 TPD-54XUEP 2-(2,6-dioxopiperidin-3-yl)-5-(pyridin-3-yl)isoindoline-1,3-dione 2-(2,6-Dioxopiperidin-3-yl)-5-(pyridin-3-yl)isoindoline-1,3-dione O=C1CCC(N2C(=O)C3=C(C=C(C4=CN=CC=C4)C=C3)C2=O)C(=O)N1 Degrader C18H13N3O4 ZNF787;PATZ1 Q6DD87/Q9HBE1 CRBN 10.1038/s41557-023-01379-8 TPD-KHD9MV 38110475_59 5-(Benzo[b]thiophen-3-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione O=C1CCC(N2C(=O)C3=C(C=C(C4=CSC5=C4C=CC=C5)C=C3)C2=O)C(=O)N1 Degrader C21H14N2O4S ZNF653;ZFP91;ZNF787;ZNF517 Q96CK0/Q96JP5/Q6DD87/Q6ZMY9 CRBN 10.1038/s41557-023-01379-8 TPD-HZSH8Y SCHEMBL20120957 2-(2,6-Dioxopiperidin-3-yl)-5-(2,6-diazaspiro[3.3]heptan-2-yl)isoindoline-1,3-dione; SCHEMBL29547652; 2-(2,6-dioxopiperidin-3-yl)-5-(2,6-diazaspiro[3.3]heptan-2-yl)isoindoline-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(N4CC5(CNC5)C4)C=C3C2=O)C(=O)N1 Degrader C18H18N4O4 ZNF276;ZNF653;ZNF827 Q8N554/Q96CK0/Q17R98 CRBN 10.1038/s41557-023-01379-8 TPD-9DLM3A SCHEMBL21946744 2-(2,6-Dioxopiperidin-3-yl)-5-(pyrrolidin-1-yl)isoindoline-1,3-dione; SCHEMBL30798398; 2-(2,6-dioxopiperidin-3-yl)-5-(pyrrolidin-1-yl)isoindoline-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(N4CCCC4)C=C3C2=O)C(=O)N1 Degrader C17H17N3O4 ZNF276;ZNF653 Q8N554/Q96CK0 CRBN 10.1038/s41557-023-01379-8 TPD-4B1CBW SCHEMBL21946896 2-(2,6-Dioxopiperidin-3-yl)-5-(piperidin-1-yl)isoindoline-1,3-dione; SCHEMBL28950949; SCHEMBL30066311; 2-(2,6-dioxopiperidin-3-yl)-5-(piperidin-1-yl)isoindoline-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(N4CCCCC4)C=C3C2=O)C(=O)N1 Degrader C18H19N3O4 ZNF517 Q6ZMY9 CRBN 10.1038/s41557-023-01379-8 TPD-U592EA 5-Aminothalidomide-cyclohexane 5-Aminothalidomide-cyclohexane; orb2664072; HY-163929; 5-(cyclohexylamino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2924858-26-2 O=C1CCC(N2C(=O)C3=CC=C(NC4CCCCC4)C=C3C2=O)C(=O)N1 Degrader C19H21N3O4 ZNF517 Q6ZMY9 CRBN 10.1038/s41557-023-01379-8 TPD-1XUO2W 2-(2,6-Dioxopiperidin-3-yl)-4-phenylisoindoline-1,3-dione 2-(2,6-Dioxopiperidin-3-yl)-4-phenylisoindoline-1,3-dione; 1216805-36-5; CHEMBL599277; SCHEMBL21477254 O=C1CCC(N2C(=O)C3=CC=CC(C4=CC=CC=C4)=C3C2=O)C(=O)N1 Degrader C19H14N2O4 ZKSC5 Q9Y2L8 CRBN 10.1038/s41557-023-01379-8 TPD-MP2GWS SCHEMBL24003517 2-(2,6-Dioxopiperidin-3-yl)-4-(pyrrolidin-1-yl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-(pyrrolidin-1-yl)isoindoline-1,3-dione O=C1CCC(N2C(=O)C3=CC=CC(N4CCCC4)=C3C2=O)C(=O)N1 Degrader C17H17N3O4 ZNF276;ZNF653;ZNF787 Q8N554/Q96CK0/Q6DD87 CRBN 10.1038/s41557-023-01379-8 TPD-XEMDHZ Thalidomide-piperidine Thalidomide-piperidine; orb2665541; SCHEMBL25293797; SCHEMBL29497197; HY-169050; 2-(2,6-dioxopiperidin-3-yl)-4-(piperidin-1-yl)isoindoline-1,3-dione; 2924858-38-6 O=C1CCC(N2C(=O)C3=CC=CC(N4CCCCC4)=C3C2=O)C(=O)N1 Degrader C18H19N3O4 ZNF517 Q6ZMY9 CRBN 10.1038/s41557-023-01379-8 TPD-AVLHFT Pomalidomide-cyclohexane Pomalidomide-cyclohexane; orb2664513; HY-163928; 4-(cyclohexylamino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2924858-40-0 O=C1CCC(N2C(=O)C3=CC=CC(NC4CCCCC4)=C3C2=O)C(=O)N1 Degrader C19H21N3O4 ZNF517;ZNF787;ZNF276;ZNF653;ZNF654 Q6ZMY9/Q6DD87/Q8N554/Q96CK0/Q8IZM8 CRBN 10.1038/s41557-023-01379-8 TPD-F67746 39324213_SB1349 . COC1=CC=C(C(=O)/C=C/C(=O)N2CCN(C3=CC4=C(C=C3[N+](=O)[O-])C3=C(C=NN3C3=CC=C(C(=O)O)C=C3)C(C)(C)O4)CC2)C=C1 Degrader C34H31N5O8 Lin28 Q9H9Z2 RNF126 10.1039/d4cc03614j TPD-9N305A VHL Ligand 14 VHL Ligand 14; 2010986-87-3; (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide; CHEMBL4565531; (2s,4r)-1-((s)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-((s)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide; orb2565072; SCHEMBL18063907; BDBM50615684; GS-9690; BP-42121; HY-150803; CS-0564250; EN300-28311075; Z4921517774 CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)C1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C Degrader C25H34N4O4S CDO1 Q16878 VHL 10.1038/s41589-025-01936-x TPD-NDJ9FS VH032 N-Acetyl-3-Methyl-L-Valyl-(4r)-4-Hydroxy-N-[4-(4-Methyl-1,3-Thiazol-5-Yl)benzyl]-L-Prolinamide; 1448188-62-2; VH-032; N-Acetyl-3-Methyl-L-Valyl-(4r)-4-Hydroxy-N-[4-(4-Methyl-1,3-Thiazol-5-Yl)benzyl]-L-Prolinamide; (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide; CHEMBL3344081; (2S,4R)-1-[(2S)-2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOYL]-4-HYDROXY-N~2~-[4-(4-METHYL-1,3-THIAZOL-5-YL)BENZYL]TETRAHYDRO-1H-PYRROLE-2-CARBOXAMIDE; (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 3JF; MFCD33548811; 4w9h; orb1699013; VHL032; SCHEMBL15126287; ARV-056; GLXC-10948; EX-A6313; BDBM50099062; VL-269; AKOS040749751; VH-032?; (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; AC-37808; BP-41576; DA-58997; MS-28751; SY392674; HY-120217; CS-0077220; G17720; EN300-26936924; Q27453846; Z3482164376; (2S,4R)-1-((S)-2-ACETAMIDO-3,3-DIMETHYLBUTANOYL)-4-HYDROXY-N-(4-(4-METHYLTHIAZOL-5-YL)BENZYL)PYRROLI; (2S,4R)-1-[(S)-2-Acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[4-(4-methyl-5-thiazolyl)benzyl]pyrrolidine-2-carboxamide CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C Degrader C24H32N4O4S CDO1 Q16878 VHL 10.1038/s41589-025-01936-x TPD-BE8UI1 SCHEMBL15126216 US10730870, Example 69; WGZJLQXDRGNUFL-AABGKKOBSA-N; BDBM454902; US10730870, Example 69; (2S,4R)-1-((S)-2-acetamido-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)C Degrader C23H30N4O4S CDO1 Q16878 VHL 10.1038/s41589-025-01936-x TPD-QH4CE8 40555806_7 . CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C2=CC=CC=C12)C(C)(C)C Degrader C28H34N4O4S CDO1 Q16878 VHL 10.1038/s41589-025-01936-x TPD-OD0WFN CDO1 degrader-1 CDO1 degrader-1; A1ACI; HY-160525; CS-1005676 CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=CC=NN2)C2=CC=CC=C12)C(C)(C)C Degrader C27H33N5O4 CDO1 Q16878 VHL 10.1038/s41589-025-01936-x TPD-PSR3FU VH298 VH298; 2097381-85-4; VH-298; MFCD30742947; VH 298; (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide; (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CHEMBL4225537; (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; (2~{s},4~{r})-1-[(2~{s})-2-[(1-Cyanocyclopropyl)carbonylamino]-3,3-Dimethyl-Butanoyl]-~{n}-[[4-(4-Methyl-1,3-Thiazol-5-Yl)phenyl]methyl]-4-Oxidanyl-Pyrrolidine-2-Carboxamide; orb1296188; SCHEMBL21987823; C27H33N5O4S; GLXC-10388; EX-A1505; BDBM50459944; NSC798201; s8449; AKOS032947181; CS-7721; NSC-798201; AC-36151; BP-28199; BV165083; SY355720; VH298, >=98% (HPLC); HY-100947; C73971; Z2967326566; (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide; (2S,4R)-1-[(S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[4-(4-methyl-5-thiazolyl)benzyl]pyrrolidine-2-carboxamide; 6Z3 CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(C#N)CC3)C(C)(C)C)C=C2)SC=N1 Degrader C27H33N5O4S CDO1 Q16878 VHL 10.1038/s41589-025-01936-x TPD-G2EME5 1448188-69-9 (2S,4R)-4-hydroxy-N-((2-hydroxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl)-1-((2S)-3-methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoyl)pyrrolidine-2-carboxamide; (2S,4R)-4-hydroxy-N-{[2-hydroxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-1-[(2S)-3-methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoyl]pyrrolidine-2-carboxamide; (2S,4R)-4-hydroxy-N-((2-hydroxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl)-1-((2S)-3-methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoyl)pyrrolidine-2-carboxamide; 872-103-6; VL285 Phenol; (2S,4R)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide; MFCD31746640; (2S,4R)-4-hydroxy-N-[[2-hydroxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2S)-3-methyl-2-(3-oxo-1H-isoindol-2-yl)butanoyl]pyrrolidine-2-carboxamide; starbld0013374; orb2565067; SCHEMBL15111764; KNZQRBRUYSXXRG-VTZPFEBOSA-N; AT11307; DA-59033; SY310129; HY-151227; CS-0610233; EN300-6729776; (2S,4R)-4-Hydroxy-N-[2-hydroxy-4-(4-methyl-5-thiazolyl)benzyl]-1-[(S)-3-methyl-2-(1-oxo-2-isoindolinyl)butanoyl]pyrrolidine-2-carboxamide CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)C)N3CC4=CC=CC=C4C3=O)C(O)=C2)SC=N1 Degrader C29H32N4O5S CDO1 Q16878 VHL 10.1038/s41589-025-01936-x TPD-9M3D7H 39026748_iDeg-2 . CC(C)(C)C1=CC=C(S(=O)(=O)N2C[C@H]3C[C@H]4C[C@H](C4(C)C)[C@@]3(COC(=O)NC3=CC=C(I)C=C3)C2)C=C1 Degrader C29H37IN2O4S IDO1 P14902 KLHDC3 10.1101/2024.07.10.602857 TPD-4B5RQA 39026748_iDeg-1 . CC1=CC=C(NC(=O)OC[C@]23CN(S(=O)(=O)C4=CC=C(C(C)(C)C)C=C4)C[C@H]2C[C@H]2C[C@@H]3C2(C)C)C=C1 Degrader C30H40N2O4S IDO1 P14902 KLHDC3 10.1101/2024.07.10.602857 TPD-2ISIY2 39026748_iDeg-3 CRL2KLHDC3 . CCC1=CC=C(NC(=O)OC[C@]23CN(S(=O)(=O)C4=CC=C(C(C)(C)C)C=C4)C[C@H]2C[C@H]2C[C@@H]3C2(C)C)C=C1 Degrader C31H42N2O4S IDO1 P14902 KLHDC3 10.1101/2024.07.10.602857 TPD-5XTSM7 FPFT-2216 3-(4-(4-methoxythiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidine-2,6-dione; 3-(4-(4-Methoxythiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidine-2,6-dione; 3-[4-(4-methoxythiophen-3-yl)-1H-1,2,3-triazol-1-yl]piperidine-2,6-dione; 2367619-87-0; orb1689419; CHEMBL5089479; SCHEMBL22711398; GLXC-25096; EX-A6056; AT39037; DA-73543; MS-24177; HY-145319; CS-0371235; EN300-43393878; 3-[4-(4-Methoxythiophen-3-yl)triazol-1-yl]piperidine-2,6-dione COC1=CSC=C1C1=CN(C2CCC(=O)NC2=O)N=N1 Degrader C12H12N4O3S PPIL4;PDE6D;RAB28;DTWD1 Q8WUA2/O43924/P51157/Q8N5C7 CRBN 10.1038/s41467-025-62099-w TPD-8RJF2I KPT-185 propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate; 1333151-73-7; KPT185; propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate; CHEMBL3898452; (Z)-isopropyl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate; SCHEMBL1335182; EX-A318; NLNGWFLRRRYNIL-PLNGDYQASA-N; BDBM50619732; NSC757568; NSC772595; s7125; AKOS030526414; CCG-268093; NSC-757568; NSC-772595; NCGC00386294-01; AC-32679; HY-15611; SW219337-1; BRD-K71467466-001-02-3 COC1=CC(C2=NN(/C=C\C(=O)OC(C)C)C=N2)=CC(C(F)(F)F)=C1 Degrader C16H16F3N3O3 XPO1 O14980 ASB8 10.1101/2024.10.07.617049 TPD-N5K4DF Selinexor Selinexor; 1393477-72-9; KPT-330; Xpovio; (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide; selinexorum; 31TZ62FO8F; (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide; DTXSID801026013; 2-Propenoic acid, 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-, 2-(2-pyrazinyl)hydrazide, (2Z)-; 2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)-; (2Z)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(pyrazin-2-yl)prop-2-enehydrazide; (2Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)prop-2-enehydrazide; (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-triazol-1-yl)-N'-pyrazin-2-ylprop-2-enehydrazide; SINE KPT-330; ATG-010; L01XX66; DTXCID801510264; CRM1 Nuclear Export Inhibitor KPT-330; Selective Inhibitor of Nuclear Export KPT-330; Selinexor (KPT-330); KPT 330; Selinexor free base; 1621865-82-4; Selinexor [USAN:INN]; KPT330; UNII-31TZ62FO8F; Nexpovio; Selinexor [INN]; KPT330; Selinexor; MFCD27987944; Xpovio (TN); Selinexor (Standard); SELINEXOR [MI]; Selinexor (USAN/INN); SELINEXOR [USAN]; KPT-330(Selinexor)?; SELINEXOR [WHO-DD]; orb1301068; SELINEXOR [ORANGE BOOK]; CHEMBL3545185; SCHEMBL14678327; SCHEMBL29356611; GTPL10036; EX-A870; CHEBI:229764; HMS5085B14; BDBM50527778; HY-17536R; NSC780203; NSC781780; AKOS027325566; CCG-269161; DB11942; NSC-780203; NSC-781780; NCGC00386310-01; NCGC00386310-03; NCGC00386310-04; AC-33645; BS-15022; compound 70 [WO2013019561A1]; DA-54660; HY-17536; NS00073121; S7252; SW219336-1; D11222; EN300-7360494; BRD-K21361524-001-01-1; Q27256082; (2Z)-2-(2-Pyrazinyl)hydrazide-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid; (2Z)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1- yl}-N'-(pyrazin-2-yl)prop-2-enehydrazide; (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-yl-prop-2-enehydrazide O=C(/C=C\N1C=NC(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=N1)NNC1=CN=CC=N1 Degrader C17H11F6N7O XPO1 O14980 ASB8 10.1101/2024.10.07.617049 TPD-MSH07U 10.1101/2025.03.19.644003_3 . CC(C)(C)[C@H](NC(=O)C1=C2CCCCN2N=C1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=CC=C(Cl)C=C2Cl)C=C1 Degrader C32H37Cl2N5O4 GEMIN3 Q9UHI6 VHL 10.1101/2025.03.19.644003 TPD-P8RHEP 10.1101/2025.03.19.644003 _4 . CC(C)(C)[C@H](NC(=O)C1=C2OCCCN2N=C1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=CC=C(Cl)C=C2)C=C1 Degrader C31H36ClN5O5 GEMIN3 Q9UHI6 VHL 10.1101/2025.03.19.644003 TPD-C0KVHR PT-179 2-(2,6-Dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione; 2924858-25-1; 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione; orb2281152; SCHEMBL27351273; EX-A8803; BP-42117; HY-160695; CS-1013606; G87143; 2-(2,6-dioxopiperidin-3-yl)-5-morpholin-4-ylisoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(C=C(N4CCOCC4)C=C3)C2=O)C(=O)N1 Degrader C17H17N3O5 GFP P42212 CRBN 10.1126/science.adk4422 TPD-W22X62 CHEMBL1372036 1-(1,3-Benzothiazol-2-yl)-3-(4-chloro-3-nitrophenyl)urea; MLS000758504; NSC329249; SCHEMBL26034874; NSC-329249; SMR000528946 O=C(NC1=CC=C(Cl)C([N+](=O)[O-])=C1)NC1=NC2=CC=CC=C2S1 Degrader C14H9ClN4O3S SUMO1 P63165 FBXO4 10.1126/scitranslmed.abh1486 TPD-04PVLD HB007 CID 146255136; 2387821-46-5; 1-(3-Chlorophenyl)-3-(6-cyano-1,3-benzothiazol-2-yl)urea; orb1692712; SCHEMBL21568259; GLXC-27826; EX-A5607; HB007?; AKOS040755959; DA-53850; MS-24935; HY-139662; CS-0226713; G18534 N#CC1=CC=C2N=C(NC(=O)NC3=CC=CC(Cl)=C3)SC2=C1 Degrader C15H9ClN4OS SUMO1 P63165 FBXO4 10.1126/scitranslmed.abh1486 TPD-S2RX5Z Avadomide 1015474-32-4; cc-122; CC122; Avadomida; CC 122; 28DZS29F59; 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-; avadomidum; 3-(5-Amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; Avadomide [USAN]; Avadomide(CC-122); MFCD29919294; 3-(5-Amino-2-methyl-4-oxo-4H-quinazolin-3-yl)piperidine-2,6-dione; 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione; 2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-; 2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-; 3-[5-Amino-2-methyl-4-oxoquinazolin-3(4H)-yl]piperidine-2,6-dione; CC-122Avadomide; CC-122Avadomide?; AVADOMIDE [INN]; Avadomide (USAN/INN); AVADOMIDE [WHO-DD]; SCHEMBL282749; UNII-28DZS29F59; orb1304076; US9694015, Compound A; CC-122; CC 122; Avadomide; CHEMBL3989934; SCHEMBL29359950; BDBM76986; GTPL10522; RSNPAKAFCAAMBH-UHFFFAOYSA-N; GLXC-10604; BCP15938; EX-A1191; s7892; AKOS025399378; CCG-267340; CS-5995; DB14857; SB18829; Compound A [WO2014039960A1]; AC-33084; AS-55858; BP-27973; SY058067; DB-112299; HY-100507; C71075; D11132; EN300-3363282; Z2256160048; 3-(5-amino-2-methyl-4-oxo-quinazolin-3-yl)piperidine-2,6-dione; 3-(5-amino-2-methy-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione; 3-(5-amino-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-amino-2-methyl-4-oxo-3,4-dihydroquinazolin-3-yl)piperidine-2,6-dione; RAC-(3R)-3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE CC1=NC2=CC=CC(N)=C2C(=O)N1C1CCC(=O)NC1=O Degrader C14H14N4O3 ZMYM2;ZFP91 Q9UBW7/Q96JP5 CRBN 10.1158/2643-3230.BCD-20-0105 TPD-IGVCHO 5-Hydroxythalidomide 5-hydroxythalidomide; 64567-60-8; 29V976C3CJ; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-; 2-(2,6-dioxopiperidin-3-yl)-5-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione; Thalidomide-5-OH; 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindole-1,3-dione; (+/-)-Hydroxythalidomide; CHEMBL182442; MFCD24386541; 2-(2,6-Dioxo-3-piperidyl)-5-hydroxy-isoindoline-1,3-dione; UNII-29V976C3CJ; alpha-N-(4-Hydroxyphthalimido)-glutarimide; Thalidomide-5'-OH; Thalidomide-5-OH?; 5-HYDROXY THALIDOMIDE; orb1298209; SCHEMBL15559573; SCHEMBL29403986; DTXSID40983186; TQP0426; CHEBI:168639; 2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1,3-isoindolinedione; GLXC-23381; 172333-29-8; 250384-12-4; BCP33978; EX-A3036; BDBM50614094; AKOS040759765; AT13473; FH46213; 5-HYDROXY THALIDOMIDE, (+/-)-; AC-37437; BP-24501; HY-23095; SY233785; DS-022389; CS-0044368; EN300-7564045; Q27254447; Z2508933762; PHTHALIMIDE, N-(2,6-DIOXO-3-PIPERIDYL)-4-HYDROXY-; 2-[(3R)-2,6-dioxo-3-piperidyl]-5-hydroxy-isoindoline-1,3-dione; 2-[(3S)-2,6-dioxo-3-piperidyl]-5-hydroxy-isoindoline-1,3-dione; 5-Hydroxy-2-(6-hydroxy-2-oxo-2,3,4,5-tetrahydropyridin-3-yl)-1H-isoindole-1,3(2H)-dione O=C1CCC(N2C(=O)C3=CC=C(O)C=C3C2=O)C(=O)N1 Degrader C13H10N2O5 PLZF Q05516 CRBN 10.15252/embj.2020105375 TPD-OHF58K BTX161 (S)-3-(4-Methyl-1-oxoisoindolin-2-yl)azepane-2,7-dione; 2052301-24-1; (S)-3-(4-Methyl-1-oxoisoindolin-2-yl)azepane-2,7-dione; (3S)-3-(7-methyl-3-oxo-1H-isoindol-2-yl)azepane-2,7-dione; starbld0031958; orb1689545; SCHEMBL18270885; DA-71794; MS-23861; HY-120084; CS-0069459; G18478 CC1=CC=CC2=C1CN([C@H]1CCCC(=O)NC1=O)C2=O Degrader C15H16N2O3 FAM83F;CK1α Q8NEG4/P48729 CRBN 10.26508/lsa.202000804 TPD-7UIZH4 JA-isoleucine N-({(1r,2s)-3-Oxo-2-[(2z)-Pent-2-En-1-Yl]cyclopentyl}acetyl)-L-Isoleucine; N-[(3R,7S)-(+)-7-iso-Jasmonoyl]-(S)-isoleucine; (+)-7-iso-JA-L-Ile; (3R,7S)-JA-L-Ile; (+)-7-iso-jasmonyl-L-isoleucine; iso-JA-Ile; (+)-7-iso-JA-Ile; 145414-77-3; SCHEMBL16597078; (+)-7-isojasmonyl-L-isoleucine; CHEBI:137043; DTXSID801304786; N-[(+)-7-isojasmonyl]isoleucine; (+)-7-iso-jasmonoyl-(S)-isoleucine; N-[(+)-7-isojasmonyl]-L-isoleucine; (+)-7-isojasmonic acid-L-isoleucine conjugate; Q27456735; N-({(R,2S)-3-oxo-2-[(2Z)-pent-2-en-1-yl]cyclopentyl}acetyl)-L-isoleucine; N-[2-[(1R,2S)-3-oxo-2-(2Z)-2-penten-1-yl-cyclopentyl]acetyl]-L-isoleucine; (2S,3S)-3-methyl-2-(2-{(1R,2S)-3-oxo-2-[(2Z)-pent-2-en-1-yl]cyclopentyl}acetamido)pentanoic acid; (2S,3S)-3-methyl-2-[[2-[(1R,2S)-3-oxo-2-[(Z)-pent-2-enyl]cyclopentyl]acetyl]amino]pentanoic acid; 7JA CC/C=C\C[C@@H]1C(=O)CC[C@@H]1CC(=O)N[C@H](C(=O)O)[C@@H](C)CC Degrader C18H29NO4 Jaz1 Q3ED96 COl1 10.1038/nature09430 TPD-07N99H Coronatine Coronatine; 62251-96-1; WCR4XUE8VB; Coronatine, (+)-; DTXSID20977826; (1S,2S)-1-[[(3aS,6R,7aS)-6-ethyl-1-oxo-2,3,3a,6,7,7a-hexahydroindene-4-carbonyl]amino]-2-ethylcyclopropane-1-carboxylic acid; (1S,2S)-1-(((3aS,6R,7aS)-6-ethyl-1-oxo-2,3,3a,6,7,7a-hexahydroindene-4-carbonyl)amino)-2-ethylcyclopropane-1-carboxylic acid; DTXCID701405161; 2-ethyl-1-((6-ethyl-1-oxo-2,3,3a,6,7,7a-hexahydroindene-4-carbonyl)amino)cyclopropane-1-carboxylic acid; (+)-coronatine; Cyclopropanecarboxylic acid, 2-ethyl-1-[[[(3aS,6R,7aS)-6-ethyl-2,3,3a,6,7,7a-hexahydro-1-oxo-1H-inden-4-yl]carbonyl]amino]-, (1S,2S)-; UNII-WCR4XUE8VB; orb1981838; SCHEMBL20374645; CHEBI:80730; HY-N11420; DA-72344; CS-0646203; Q5172198; (1S,2S)-2-Ethyl-1-[[[(3aS,6R,7aS)-6-ethyl-2,3,3a,6,7,7a-hexahydro-1-oxo-1H-inden-4-yl]carbonyl]amino]cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 2-ethyl-1-(((6-ethyl-2,3,3a,6,7,7a-hexahydro-1-oxo-1H-inden-4-yl)carbonyl)amino)-; Cyclopropanecarboxylic acid, 2-ethyl-1-[[(6-ethyl-2,3,3a,6,7,7a-hexahydro-1-oxo-1H-inden-4-yl)carbonyl]amino]-, [3aS-[3aalpha,4(1R*,2R*),6beta,7aalpha]]- CC[C@@H]1C[C@H]2[C@H](CCC2=O)C(=C1)C(=O)N[C@]3(C[C@@H]3CC)C(=O)O Degrader C18H25NO4 Jaz1 Q3ED96 COl1 10.1038/nature09430 TPD-JC59JO DS22 (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol; DS22 CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C3=CN(N=C3)C)NCC4=NC5=CC(=C(C=C5N4)Cl)Cl Degrader C21H22Cl2N10O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-GKNBQF RS5 784211-09-2; RGB-286147; Cdk/Crk Inhibitor; K00600a; CHEMBL5193007; 1-(2,6-dichlorophenyl)-6-[[4-(2-hydroxyethoxy)phenyl]methyl]-3-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one; 1-(2,6-Dichlorophenyl)-6-(4-(2-hydroxyethoxy)benzyl)-3-isopropyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; 1-(2,6-Dichlorophenyl)-6-(4-(2-hydroxyethoxy)benzyl)-3-isopropyl-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; Cdk/Crk; 1-(2,6-Dichlorophenyl)-1,5-dihydro-6-((4-(2-hydroxyethoxy)phenyl)methyl)-3-(1-methylethyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one; CHEMBL258721; GTPL5943; orb1699528; SCHEMBL1179657; SCHEMBL20268038; BDBM59227; DTXSID60429556; HMS3229E20; HMS3674M03; BCP29074; BDBM50595929; AKOS040749294; CCG-206832; SDCCGSBI-0086744.P003; NCGC00345809-01; NCGC00345809-02; 1-(2,6-dichlorophenyl)-6-[[4-(2-hydroxyethoxy)phenyl]methyl]-3-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-4-one; EX-229;EX 229;AMPK Activator 991; DB-146310; HY-112346; CS-0045271; Q27075833; 1-(2,6-dichlorophenyl)-6-{[4-(2-hydroxyethoxy)phenyl]methyl}-3-(propan-2-yl)-1H,2H,4H-pyrazolo[3,4-d]pyrimidin-4-one CC(C)C1=NN(C2=C1C(=O)NC(=N2)CC3=CC=C(C=C3)OCCO)C4=C(C=CC=C4Cl)Cl Degrader C23H22Cl2N4O3 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-JCKC8Z R-ROSCOVITINE roscovitine; Seliciclib; 186692-46-6; R-Roscovitine; (R)-roscovitine; CYC202; CYC-202; Roscovitin; 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; NSC-701554; AL-39256; 0ES1C2KQ94; CHEBI:45307; (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol; DTXSID20171928; (2R)-2-((6-benzylamino-9-(propan-2-yl)-9h-purin-2-yl)amino)butan-1-ol; (2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol; R roscovitine; seliciclibum; (2R)-2-((6-(benzylamino)-9-propan-2-ylpurin-2-yl)amino)butan-1-ol; (2R)-2-((6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl)amino)butan-1-ol; DTXCID8094419; Seliciclib [INN]; Roscovitine (Seliciclib,CYC202); (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol; Seliciclib (Roscovitine); MFCD02266401; CHEMBL14762; (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol; NSC701554; CYC 202; RRC; Rosco; (2R)-2-{[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]amino}butan-1-ol; NSC 701554; UNII-0ES1C2KQ94; BMK1-E12; C19H26N6O; 1unl; 3ddq; 1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-, (2R)-; 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-; 2a4l; SELICICLIB [MI]; BiomolKI_000048; 1-Butanol, (2R)-; ROSCOVITINE(Seliciclib); BiomolKI2_000054; M02443; ROSCOVITINE(Seliciclib)?; SELICICLIB [WHO-DD]; CBiol_002016; Lopac0_001102; SCHEMBL94728; BSPBio_001078; KBioGR_000418; KBioSS_000418; MLS006011028; BDBM7533; cid_160355; GTPL6035; orb1306496; Roscovitine, >=98% (TLC); BCBcMAP01_000013; KBio2_000418; KBio2_002986; KBio2_005554; KBio3_000795; KBio3_000796; EX-A052; BCPP000087; Bio1_000302; Bio1_000791; Bio1_001280; Bio2_000379; Bio2_000859; CC205; GLXC-04786; HMS1362F19; HMS1792F19; HMS1990F19; HMS3229N13; HMS3403F19; BCP01760; Roscovitine (Seliciclib, CYC202); HSCI1_000092; MSK168158; NSC800881; 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine; AKOS005146319; AC-2416; CCG-100652; DB06195; NSC-800881; 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; IDI1_002134; Roscovitine - CAS 186692-46-6; SMP1_000266; 2,6,9-Trisubstituted purine deriv. 28; NCGC00094374-01; NCGC00094374-02; NCGC00094374-03; NCGC00094374-04; NCGC00094374-05; NCGC00094374-09; NCGC00094374-13; NCGC00094374-15; AS-56277; FR146851; HY-30237; NCI60_036420; SMR004702823; NS00068708; SW220195-1; K00020; EN300-26484982; Q3494619; BRD-K07691486-001-03-1; BRD-K07691486-001-05-6; BRD-K07691486-001-15-5; BRD-K07691486-001-19-7; Z1741982636; (2R)-2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-1-butanol; (2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol; (2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; (R)-2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-1-butanol; 1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-, (R)-; 2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]- 9H-purin-2-yl]amino]-(R)-1-butanol CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3 Degrader C19H26N6O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-BZ4VWZ RVH LTbetaR-IN-1; LT; AR-IN-1; 2189366-77-4; (2R)-N-(1H-benzimidazol-2-yl)-2-(3-oxo-1H-isoindol-2-yl)propanamide; (2~{R})-~{N}-(1~{H}-benzimidazol-2-yl)-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanamide; LT-beta-R-IN-1; orb1709239; AKOS034820579; MS-24731; HY-123984; CS-0088153; G16984; Z2894086919; RVH C[C@H](C(=O)NC1=NC2=CC=CC=C2N1)N3CC4=CC=CC=C4C3=O Degrader C18H16N4O2 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-LE2E5Z RNU . Cc1ccc(o1)C(=O)N2CSCC2C(=O)NC3NC=C(S3)C Degrader C14H17N3O3S2 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-ICSMIF RKO dCeMM3; 311787-85-6; 2-((1H-benzo[d]imidazol-2-yl)thio)-N-(5-chloropyridin-2-yl)acetamide; 2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide; 2-(1~{H}-benzimidazol-2-ylsulfanyl)-~{N}-(5-chloranylpyridin-2-yl)ethanamide; dCeMM3?; orb1297893; SCHEMBL23261485; CHEBI:232057; EX-A7645; STK121629; ZINC00051639; AKOS001731401; MS-24707; HY-144976; CS-0436574; G66728; SR-01000517615; SR-01000517615-1; Z54609541; 2-(1H-benzimidazol-2-ylthio)-N-(5-chloropyridin-2-yl)acetamide; Rko Clc1ccc(NC(=O)CSc2[nH]c3ccccc3n2)nc1 Degrader C14H11ClN4OS CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-FRR4CS RP9 N-(5-bromopyridin-2-yl)-3-(4-oxoquinazolin-3(4H)-yl)propanamide; CHEMBL4558806; SCHEMBL24341840; STK627926; AKOS005560744; Z200170434; RP9 C1=CC=C2C(=C1)C(=O)N(C=N2)CCC(=O)NC3=NC=C(C=C3)Br Degrader C16H13BrN4O2 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-TYMFUR RVU RVU CC1=CC(=C(C=C1)OC)N2C[C@H](CC2=O)C(=O)NC3=NC4=CC=CC=C4N3 Degrader C20H20N4O3 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-G32VK8 RW6 2-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dimethoxy-3~{H}-quinazolin-4-one; AKOS016898418; Z225160068; RW6 COC1=C(C=C2C(=C1)C(=O)NC(=N2)CN3CCC4=C(C3)C=CS4)OC Degrader C18H19N3O3S CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-52M245 RR9 6-[[[2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-9-propan-2-yl-purin-6-yl]amino]methyl]-3-pyridin-2-yl-1~{H}-pyridin-2-one; RR9; WX3 CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C(=O)N3)C4=CC=CC=N4 Degrader C23H28N8O2 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-NLQFSE RV6 CHEMBL518813; (2R)-2-{[9-(propan-2-yl)-6-{[4-(pyridin-2-yl)phenyl]amino}-9H-purin-2-yl]amino}butan-1-ol; 1056016-38-6; (2~{R})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-ol; RV6; DRF053; SCHEMBL25001230; BDBM50479427; EN300-44822483 CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC=C(C=C3)C4=CC=CC=N4 Degrader C23H27N7O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-GQ8MCM RUW (2~{R})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; RUW; DS06 CCCCCCCCNC1=C2C(=NC(=N1)N[C@H](CC)CO)N(C=N2)C(C)C Degrader C20H36N6O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-O2IH3S RWE (2~{R})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; DS08; Rwe CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC4=CC=CC=C4C=C3 Degrader C23H28N6O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-PGH6ER T6X (2R)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; T6X; DS15 CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCCCCCC3=CC=CC4=CC=CC=C43 Degrader C27H36N6O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-XVN4LY RLC (2~{R})-2-[[6-[(3-fluoranyl-4-pyridin-2-yl-phenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; DS24; RLC CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC(=C(C=C3)C4=CC=CC=N4)F Degrader C24H28FN7O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-EZ9SR6 RWN (2~{R})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; DS30; RWN CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCCCC3=CC=CC(=C3)C Degrader C22H32N6O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-RZMW0M RQ9 (2~{R})-2-[[6-[[1-(3-chlorophenyl)pyrazol-3-yl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol; DS43; RQ9 CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=NN(C=C3)C4=CC(=CC=C4)Cl Degrader C22H27ClN8O CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-J5J9IM RQU DS50; RQU CC(C)N1C=NC2=C(N=C(N=C21)NCC(=O)NCCC3=CC=CC=C3OC)NCC4=CC=C(C=C4)C5=CC=CC=N5 Degrader C31H34N8O2 CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-NYQYLZ RMX 1,3-dimethyl-5-[[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]methyl]pyrazole-4-sulfonamide; DS59 CC1=NN(C(=C1S(=O)(=O)N)CNC2=NC(=C3C(=N2)N(C=N3)C(C)C)NCC4=CC=C(C=C4)C5=CC=CC=N5)C Degrader C26H30N10O2S CDK12;CCNK Q9NYV4/O75909 DDB1 10.1038/s41589-023-01409-z TPD-GO9X29 F4U (S)-2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione; 2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-5-oxidanyl-isoindole-1,3-dione; (S)-Hydrothalidomide; CHEMBL560448; 172333-29-8; NS00116820; F4U C1CC(=O)NC(=O)[C@H]1N2C(=O)C3=C(C2=O)C=C(C=C3)O Degrader C13H10N2O5 SALL4 Q9UJQ4 CRBN 10.1038/s41467-020-18488-4 TPD-XXRA06 5a 2133815-88-8; CHEMBL4520346; 4-amino-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione; SCHEMBL19359302; SCHEMBL29923654; BDBM50516584; AT41535; EN300-43358976; 4-AMINO-2-(2,5-DIOXOPYRROLIDIN-3-YL)ISOINDOLINE-1,3-DIONE NC1=CC=CC2=C1C(=O)N(C1CC(=O)NC1=O)C2=O Degrader C12H9N3O4 IKZF3 Q9UKT9 CRBN 10.1021/acs.jmedchem.9b00454 TPD-XTP83X 7f CHEMBL4521923; compound 7f [PMID: 31251063]; GTPL10523; BDBM50516592; N-(2,5-Dioxopyrrolidin-3-yl)cinnamamide O=C(/C=C/C1=CC=CC=C1)NC1CC(=O)NC1=O Degrader C13H12N2O3 IKZF3 Q9UKT9 CRBN 10.1021/acs.jmedchem.9b00454 TPD-GCSKN5 7d 84767-67-9; CHEMBL4464143; Benzyl (2,5-dioxopyrrolidin-3-yl)carbamate; Benzyl(R)-(2,5-dioxopyrrolidin-3-yl)carbamate; benzyloxycarbonylaminosuccinimide; SCHEMBL3930648; BDBM50516601; AB22870; AB29506; DB-016832; EN300-7292653; BENZYL N-(2,5-DIOXOPYRROLIDIN-3-YL)CARBAMATE O=C1CC(NC(=O)OCC2=CC=CC=C2)C(=O)N1 Degrader C12H12N2O4 IKZF3 Q9UKT9 CRBN 10.1021/acs.jmedchem.9b00454 TPD-LM28HA A1AE9 A1AE9 CC(=O)N1CC2=C(C=NN2C[C@@H]1CC3=CC=CC=C3)C4=CC=C(C=C4)C(=O)N5CCCC6=CC=CC=C65 Stabilizer C31H30N4O2 Ubiquitin;Parkin P0CG47/O60260 . 10.1038/s41467-024-51889-3 TPD-MIF4BT A1A5I A1A5I; SCHEMBL24938494 CCN1C[C@@H](CC[C@@H]1C)OC2=CC3=C(C=C2)C(=O)N(C3)[C@H]4CCC(=O)NC4=O Degrader C21H27N3O4 WIZ O95785 CRBN 10.1021/acs.jmedchem.4c02251 TPD-51O8A6 A1A8N A1A8N; SCHEMBL26518577 C1CC(=O)NC(=O)[C@H]1N2CC3=C(C2=O)C=CC4=C3OCC45CCN(CC5)CC6=CC=CC=C6 Degrader C26H27N3O4 IKZF2 Q9UKS7 CRBN 10.1038/s41467-025-58431-z TPD-M5YQ3Z IBG1 PROTAC BRD4 Degrader-19; 2684292-71-3; methyl 2-[(9~{S})-7-[4-[4-[[4-[(3-cyano-4-methyl-1~{H}-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoate; orb1982275; SCHEMBL25447477; SCHEMBL30080513; US11890288, Compound 1; BDBM649469; EX-A8498; BP-42205; HY-153459; CS-0775165; G86902; methyl 2-[(9S)-7-[4-[4-[[4-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate; U79 CC1=C2C(=CNC2=C(C=C1)NS(=O)(=O)C3=CC=C(C=C3)CNC(=O)C4=CC=C(C=C4)C5=CC=C(C=C5)C6=N[C@H](C7=NN=C(N7C8=C6C(=C(S8)C)C)C)CC(=O)OC)C#N Degrader C44H38N8O5S2 BRD4 O60885 DCAF16 10.1038/s41586-024-07089-6 TPD-OQLKIG YK3 MMH2-NR; HY-157592; CS-0996604 CCS(=O)(=O)NC1=CC=C(C=C1)C2=N[C@H](C3=NN=C(N3C4=C2C(=C(S4)C)C)C)CC(=O)OC(C)(C)C Degrader C25H31N5O4S2 BRD4 O60885 DCAF16 10.1101/2023.02.14.528208 TPD-FVAIJG NK7-902 A1ISP CCN[C@@H]1CC[C@H]2CC[C@@H]1N2C3=CC4=C(C=C3)C(=O)N(C4=O)[C@H]5CCC(=O)NC5=O Degrader C22H26N4O4 NEK7 Q8TDX7 CRBN 10.1016/j.chembiol.2025.06.005 TPD-2446B1 RN9 3-[3-[[1-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(oxidanylidene)pyrrol-3-yl]amino]phenyl]-~{N}-(3-chloranyl-4-methyl-phenyl)propanamide; RN9 CC1=C(C=C(C=C1)NC(=O)CCC2=CC(=CC=C2)NC3=CC(=O)N(C3=O)[C@H]4CCC(=O)NC4=O)Cl Degrader C25H23ClN4O5 IKZF2 Q9UKS7 CRBN 10.1038/s41589-021-00802-w TPD-9G693K CCT373566 CCT373566; (2S)-10-[[5-chloro-2-[(3R,5S)-3-hydroxy-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one; (2S)-10-((5-chloro-2-((3R,5S)-3-hydroxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-(1,4)oxazepino(2,3-c)quinolin-6-one; 2378853-66-6; CHEMBL5205388; orb1686176; SCHEMBL21483537; SCHEMBL30596452; GSGDUDAFETZSPM-IATAILRESA-N; GLXC-25861; EX-A6965; BDBM50606290; CCT-373566; DA-51687; HY-146185; F91886; (S)-10-((5-chloro-2-((3R,5S)-3-hydroxy-5-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-6(7H)-one C[C@H]1C[C@H](CN(C1)C2=NC=C(C(=N2)NC3=CC4=C(C=C3)N(C(=O)C5=C4N[C@H](C(CO5)(F)F)C6CC6)C)Cl)O Degrader C26H29ClF2N6O3 BCL6 P41182 . 10.1021/acs.jmedchem.1c02175 TPD-JH01FH Tasisulam Tasisulam; 519055-62-0; LY573636; N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide; 1YC4W9MSLJ; N-((5-BROMOTHIOPHEN-2-YL)SULFONYL)-2,4-DICHLOROBENZAMIDE; LY-573636; DTXSID20199869; N-[(5-bromothiophen-2-yl)sulfonyl]-2,4-dichlorobenzamide; tasisulamum; DTXCID30122360; 965-512-7; LY 573636; Tasisulam [INN]; N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide; Tasisulam (sodium); MFCD11973637; LY 573636 (sodium); N-(5-bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzamide; UNII-1YC4W9MSLJ; C11H6BrCl2NO3S2; Tasisulam(LY573636); TASISULAM [WHO-DD]; Tasisulam (LY573636); Tasisulam(LY573636)?; orb1300994; SCHEMBL1581371; CHEMBL2110587; N-[(5-bromo-2-thienyl)sulfonyl]-2,4-dichloro-benzamide; SCHEMBL29376914; CHEBI:231621; HMS3653O12; BCP05154; EX-A1367; s7326; AKOS027250790; BCP9000890; CCG-268827; DB11941; SB19401; NCGC00386305-05; AC-32975; AS-38576; HY-14804; DB-071449; CS-0003569; NS00069285; SW219181-1; EN300-6492968; BRD-K42495768-001-01-7; Q27253184; Z442229142; Benzamide, N-((5-bromo-2-thienyl)sulfonyl)-2,4-dichloro-; P7M C1=CC(=C(C=C1Cl)Cl)C(=O)NS(=O)(=O)C2=CC=C(S2)Br Degrader C11H6BrCl2NO3S2 RBM39 Q14498 DCAF15 10.1038/s41589-019-0378-3 TPD-S0DNGC TQW SCHEMBL25167882; PD194647 COC1=CC2=C(C=C1)N(CCC2)S(=O)(=O)C3=CC=C(C=C3)C=O Stabilizer C17H17NO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.9b01942 TPD-63QC3Y TVB PD194644 C[C@@H]1CCC2=CC=CC=C2N1S(=O)(=O)C3=CC=C(C=C3)C=O Stabilizer C17H17NO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.9b01942 TPD-OENW8F TWE SCHEMBL23884758; PD194646 C1CN(CCC1C#N)C(=O)C2=CC=C(C=C2)C=O Stabilizer C14H14N2O2 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-2L75M3 TZK 4-[(4-METHYLPHENYL)SULPHONYL]MORPHOLINE; 4-((4-Methylphenyl)sulphonyl)morpholine; 228-731-2; 4-tosylmorpholine; 6339-26-0; 4-(4-methylphenyl)sulfonylmorpholine; 4-(p-Tolylsulfonyl)morpholine; 4-(4-methylbenzenesulfonyl)morpholine; 4-[(4-Methylphenyl)sulfonyl]morpholine; Morpholine, 4-(p-tolylsulfonyl)-; MFCD00196072; Morpholine, 4-((4-methylphenyl)sulfonyl)-; Morpholine, 4-[(4-methylphenyl)sulfonyl]-; PYW39YE2V4; 4-[(4-Methylbenzene)sulfonyl]morpholine; NSC-12118; 4-(Toluene-4-sulfonyl)-morpholine; 4-((4-Methylphenyl)sulfonyl)morpholine; N-(p-Toluenesulfonyl)morpholine; EINECS 228-731-2; BRN 0210845; tosylmorpholine; AI3-30824; NSC12118; UNII-PYW39YE2V4; Oprea1_144727; Oprea1_757999; CBDivE_003744; 4-27-00-00616 (Beilstein Handbook Reference); SCHEMBL171151; 4-(p-Tolylsulphonyl)morpholine; SCHEMBL3342226; SCHEMBL8726184; SCHEMBL28152229; DTXSID10212793; HMS1607K16; NSC 12118; STL089650; AKOS001586388; NCGC00181906-01; AS-64189; ST001644; SY125741; 4-[(4-Methylphenyl)sulfonyl]morpholine #; CS-0036083; Morpholine, 4-((4-methylphenyl)sulphonyl)-; NS00035427; W11725; AE-848/00888033; Z45515795 CC1=CC=C(C=C1)S(=O)(=O)N2CCOCC2 Stabilizer C11H15NO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-Y18WV5 TZH . CC1=CC(=C(C=C1)[N+](=O)[O-])OC(=O)C2CCC2 Stabilizer C12H13NO4 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-L5F10A TWQ SCHEMBL23884768; PD193865 CO[C@H]1CCCN(C1)C2=C(C=CC(=C2)C=O)[N+](=O)[O-] Stabilizer C13H16N2O4 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-QST2W3 TZW SCHEMBL23884828; PD193869 C1CN(CCC1O)C2=C(C=CC(=C2)C=O)[N+](=O)[O-] Stabilizer C12H14N2O4 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-7UJTO9 U1B 4-nitro-3-[(3S)-3-oxidanylpiperidin-1-yl]benzaldehyde; SCHEMBL23884712; PD195436 C1C[C@@H](CN(C1)C2=C(C=CC(=C2)C=O)[N+](=O)[O-])O Stabilizer C12H14N2O4 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-QN4Z0E UGE SCHEMBL23884702; PD193542 C1CC2=CC=CC=C2N(C1)S(=O)(=O)C3=CC=C(C=C3)C=O Stabilizer C16H15NO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-PXG25O UG8 4-(piperidine-1-sulfonyl)benzaldehyde; 741705-00-0; 4-piperidin-1-ylsulfonylbenzaldehyde; 4-(piperidin-1-ylsulfonyl)benzaldehyde; SCHEMBL2798288; KUSDDEPOUVZOCG-UHFFFAOYSA-N; 4-(1-piperidylsulfonyl)benzaldehyde; MFCD11869161; AKOS023555033; 4-(piperidine-1-sulfonyl) benzaldehyde; NS-03808; PD193200; DB-112728 C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C12H15NO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-XRH49F UGQ 20335-69-7; Isoquinoline, 1,2,3,4-tetrahydro-2-(p-tolylsulfonyl)-; Isoquinoline, 1,2,3,4-tetrahydro-2-[(4-methylphenyl)sulfonyl]-; DTXSID10298577; Isoquinoline, 1,2,3,4-tetrahydro-2-((4-methylphenyl)sulfonyl)-; DTXCID40249714; ABXZGZXVLBYJDK-UHFFFAOYSA-N; 2-Tosyl-1,2,3,4-tetrahydroisoquinoline; 2-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline; 2-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline; 2-[(4-Methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline; 2-(4-METHYLBENZENESULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE; NSC124439; TimTec1_003154; Oprea1_408863; Oprea1_816059; MLS001205087; 2-(p-tolylsulfonyl)-1,2,3,4-Tetrahydro-isoquinoline; CHEMBL1327868; SCHEMBL13302259; HMS1542P08; HMS2829E08; STK008628; AKOS000579719; HS-3254; NSC-124439; N-tosyl-1,2,3,4-tetrahydroisoquinoline; SMR000515488; ST042473; DB-311346; SR-01000399575; SR-01000399575-1; 1,2,3,4-Tetrahydro-2-(p-tolylsulfonyl )isoquinoline; BRD-K76147950-001-01-1; Isoquinoline,2,3,4-tetrahydro-2-(p-tolylsulfonyl)-; Isoquinoline,2,3,4-tetrahydro-2-[(4-methylphenyl)sulfonyl]-; 2-[(4-Methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline # CC1=CC=C(C=C1)S(=O)(=O)N2CCC3=CC=CC=C3C2 Stabilizer C16H17NO2S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-NYG2RA UGN . CC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)CC(C)C Stabilizer C15H24N2O2S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-9L2GNL UHT SCHEMBL23884744; PD194329 CN(C1CCCCC1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C14H19NO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-9XEFJW UHW 195155-27-2; 4-((4-Methylpiperazin-1-yl)sulfonyl)benzaldehyde; 4-(4-methyl-piperazine-1-sulfonyl)-benzaldehyde; SCHEMBL848317; YIEAFXUNUVTOQC-UHFFFAOYSA-N; AJB88170; PD194330; DB-106353; 4-(4-methyl-piperazine-1-sulfonyl)benzaldehyde; 4-(4-methylpiperazin-1-ylsulfonyl)benzaldehyde CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C12H16N2O3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-8K3ZXB UHN SCHEMBL23884850; PD195065 C1CCN(C1)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)C=O Stabilizer C16H22N2O3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-JSQ22L UHQ SCHEMBL23884723; PD195060 CN(C)C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C14H20N2O3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-UJHCQX S9E SCHEMBL23884605; PD195069 C1=CC(=NC=C1C=O)N2C=CN=C2Br Stabilizer C9H6BrN3O 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-UC7X16 UHZ PD195066 CS(=O)(=O)OC1=C(C=CC(=C1)C=O)[N+](=O)[O-] Stabilizer C8H7NO6S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-PC88ZB UOT PD193588 COC1=CC2=C(C=C1)N=C(N2C3=CC=C(C=C3)C=O)Cl Stabilizer C15H11ClN2O2 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-BL24WS UST SCHEMBL23884696; PD194266 C1CN(C2=CC=CC=C21)S(=O)(=O)C3=CC=C(C=C3)C=O Stabilizer C15H13NO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-HQT8GO USW SCHEMBL23884856; PD194265 C1COC2=C(N1S(=O)(=O)C3=CC=C(C=C3)C=O)C=CC(=C2)Cl Stabilizer C15H12ClNO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-M11BY9 UT8 SCHEMBL25166771; PD193182 COC1=CC2=C(C=C1)N(CCO2)S(=O)(=O)C3=CC=C(C=C3)C=O Stabilizer C16H15NO5S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-JI8OSP UVK SCHEMBL25166807; SCHEMBL30231372; PD195150 C1COC2=C(N1S(=O)(=O)C3=CC=C(C=C3)C=O)C=C(C=C2)F Stabilizer C15H12FNO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-Q1XHIP UVE SCHEMBL25166791; PD195149 C1COC2=CC=CC=C2N1S(=O)(=O)C3=CC=C(C=C3)C=O Stabilizer C15H13NO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-0R2IGW UVZ SCHEMBL23884826; PD195143 C1CC2=C(C=CC(=C2)Cl)N(C1)S(=O)(=O)C3=CC=C(C=C3)C=O Stabilizer C16H14ClNO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-961LY1 UVQ SCHEMBL23884852; PD195147 C1CC2=C(C=CC(=C2)F)N(C1)S(=O)(=O)C3=CC=C(C=C3)C=O Stabilizer C16H14FNO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-3R333U UVN SCHEMBL23884729; PD194337 C1CN(CC(=O)N1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C11H12N2O4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-PO0F6Q UVH SCHEMBL25166938; PD194342 CC(C)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C14H20N2O3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-1MDGZK UVB SCHEMBL22042461; PD194341 C1CC(CN(C1)S(=O)(=O)C2=CC=C(C=C2)C=O)O Stabilizer C12H15NO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-A3XGB1 UVT SCHEMBL25171307; PD194338 C[C@H]1CCCN1S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C12H15NO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-9UN80T UWH SCHEMBL23884747; PD193268 COCCN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C14H20N2O4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-GWJK7J UWQ SCHEMBL23884718; PD193618 COC1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C13H17NO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-KM6D7J UWK PD193265 CO[C@@H]1CCCN(C1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C13H17NO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-C72LQO UXN SCHEMBL23884770; PD193264; 4-methanoyl-~{N}-methyl-~{N}-(oxan-4-yl)benzenesulfonamide CN(C1CCOCC1)S(=O)(=O)C2=CC=C(C=C2)C=O Stabilizer C13H17NO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-83QP1D V0Q AKOS015093269 CCN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)CO Stabilizer C13H20N2O3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-1DQ0YC V0T . C1CN(CCC1O)S(=O)(=O)C2=CC=C(C=C2)CO Stabilizer C12H17NO4S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-BRG7RR V0W Enamine_003063; Oprea1_505597; CHEMBL1626299; SCHEMBL17084934; HMS1402L05; AKOS024288105; ST51039667; 4-methyl-1-[(4-methylphenyl)sulfonyl]-1,4-diazaperhydroepine CC1=CC=C(C=C1)S(=O)(=O)N2CCCN(CC2)C Stabilizer C13H20N2O2S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-2G0KV3 V1K . CC1=CC=C(C=C1)S(=O)(=O)N2C3=C(C=CC(=C3)OC)N=C2Cl Stabilizer C15H13ClN2O3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-URLU82 V1Q 4-methyl-N-(1-methyl-1H-pyrazol-3-yl)benzenesulfonamide; STL396765; AKOS001163091; ST45070686; AK-968/43543307; [(4-methylphenyl)sulfonyl](1-methylpyrazol-3-yl)amine; Z123605534; 4-METHYL-N~1~-(1-METHYL-1H-PYRAZOL-3-YL)-1-BENZENESULFONAMIDE CC1=CC=C(C=C1)S(=O)(=O)NC2=NN(C=C2)C Stabilizer C11H13N3O2S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-SHJ4GE V1E 599-69-9; N,N-DIMETHYL-P-TOLUENESULFONAMIDE; Benzenesulfonamide, N,N,4-trimethyl-; p-Toluenesulfonamide, N,N-dimethyl-; N,N-Dimethyl p-toluenesulfonamide; AI3-00815; NSC 2229; EINECS 209-971-7; BRN 1873124; Benzenesulfonamide, N,N-dimethyl-4-methyl-; DTXSID9060520; 4,N,N-Trimethylbenzenesulfonamide; N,N,4-Trimethyl-benzenesulfonamide; 4-11-00-00377 (Beilstein Handbook Reference); N-[(4-Methylphenyl)sulfonyl]dimethylamine; N-((4-Methylphenyl)sulfonyl)dimethylamine; DTXCID7042724; Benzenesulfonamide, N,N-dimethyl-4-methyl-(9CI); WZKOKGOAHBIPCI-UHFFFAOYSA-N; N,N,4-trimethylbenzenesulfonamide; N,N-Dimethyl-p-toluenesulphonamide; MFCD00152452; N,N,4-trimethylbenzene-1-sulfonamide; NSC-2229; 4,N,N-Trimethyl-benzenesulfonamide; Enamine_005742; trimethylbenzenesulfonamide; AM7HU644XP; SCHEMBL82589; WLN: 1N1&SWR D1; SCHEMBL6710649; SCHEMBL9835897; N,N,4-trimethylbenzenesulonamide; NSC2229; CHEBI:195024; HMS1410E22; HMS5161K18; N,N-Dimethyl-p-toluene sulfonamide; STK016723; AKOS000277267; dimethyl[(4-methylphenyl)sulfonyl]amine; IDI1_007977; N1,N1,4-trimethylbenzene-1-sulfonamide; BS-49629; ST021070; SY083801; CS-0197310; NS00034274; EN300-136666; N11575; Z45527547; 20725-56-8 CC1=CC=C(C=C1)S(=O)(=O)N(C)C Stabilizer C9H13NO2S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-T9F99Z V1H . CC1=CC=C(C=C1)S(=O)(=O)N2CC(C2)OC Stabilizer C11H15NO3S 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-UIUUBK V2E 101682-70-6; 3-(4-Morpholinyl)-4-nitrobenzaldehyde; 3-morpholino-4-nitrobenzaldehyde; 3-morpholin-4-yl-4-nitrobenzaldehyde; SCHEMBL23884693; DTXSID401286708; PD194466 C1COCCN1C2=C(C=CC(=C2)C=O)[N+](=O)[O-] Stabilizer C11H12N2O4 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-EO9E8E V2K PD194464 CC1=NC2=C(N1C3=CC=C(C=C3)C=O)C=CC(=C2)OC Stabilizer C16H14N2O2 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-Q3SVO6 V2Q SCHEMBL23884753; PD194468 COC1CN(C1)C(=O)C2=CC=C(C=C2)C=O Stabilizer C12H13NO3 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-QVR36M V2T SCHEMBL23884739; PD194438 CN1C=CC(=N1)NC(=O)C2=CC=C(C=C2)C=O Stabilizer C12H11N3O2 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-Q9N1XB V2W SCHEMBL23884738; PD194461 COC1=CC=C(C=C1)CNC(=O)C2=CC=C(C=C2)C=O Stabilizer C16H15NO3 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-9MBGUB V32 4-(MORPHOLINE-4-CARBONYL)BENZALDEHYDE; 58287-80-2; DTXSID70608830; DTXCID40559587; 4-(Morpholine-4-Carbonyl)-Benzaldehyde; MFCD09758996; SCHEMBL1662915; SCHEMBL7338701; 4-morpholinylcarbonylbenzaldehyde; WVDVJQSVTBHGQL-UHFFFAOYSA-N; AKOS015995716; 4-[(morpholin-4-yl)carbonyl]benzaldehyde; AS-43771; DA-04672; PD194465; EN300-305450; Z1068001548 C1COCCN1C(=O)C2=CC=C(C=C2)C=O Stabilizer C12H13NO3 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-VZEBMM V3B SCHEMBL25167884; PD194447 CN(C)C(=O)N1CCN(CC1)C(=O)C2=CC=C(C=C2)C=O Stabilizer C15H19N3O3 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-XJZY67 V3K SCHEMBL22042473; PD194470 CN1C=C(C=N1)CNC(=O)C2=CC=C(C=C2)C=O Stabilizer C13H13N3O2 14-3-3σ;p65 P31947/Q04206 . 10.1021/acs.jmedchem.1c00401 TPD-1RDS2Z K5Z 5-(3-azanylpropyl)-4-phenyl-thiophene-2-carboximidamide; K5Z C1=CC=C(C=C1)C2=C(SC(=C2)C(=N)N)CCCN Stabilizer C14H17N3S 14-3-3σ;TAZ P31947/Q9GZV5 . 10.1021/acs.jmedchem.9b01942 TPD-RS59WR K6B 7-(6-azanylpyridin-2-yl)-1-benzothiophene-2-carboximidamide; K6B C1=CC2=C(C(=C1)C3=NC(=CC=C3)N)SC(=C2)C(=N)N Stabilizer C14H12N4S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-S1D894 K6N 7-(3-azanyl-4-methyl-pyrazol-1-yl)-1-benzothiophene-2-carboximidamide; K6N CC1=CN(N=C1N)C2=CC=CC3=C2SC(=C3)C(=N)N Stabilizer C13H13N5S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-GXM3P4 K6T 5-[(3-aminophenyl)amino]-4-phenyl-thiophene-2-carboximidamide; K6T C1=CC=C(C=C1)C2=C(SC(=C2)C(=N)N)NC3=CC=CC(=C3)N Stabilizer C17H16N4S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-TPQBG3 K6W 4-phenyl-5-(phenylmethyl)thiophene-2-carboximidamide; K6W C1=CC=C(C=C1)CC2=C(C=C(S2)C(=N)N)C3=CC=CC=C3 Stabilizer C18H16N2S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-HGVS4C K6Z 4-phenyl-5-phenylazanyl-thiophene-2-carboximidamide; K6Z C1=CC=C(C=C1)C2=C(SC(=C2)C(=N)N)NC3=CC=CC=C3 Stabilizer C17H15N3S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-9RXIXT K7N 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide; K7N C1=CC=C(C=C1)C2=C(SC(=C2)C(=N)N)C3=CN(C=N3)CCN Stabilizer C16H17N5S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-INMPB9 K7Q K7Q COC1=C2C(=C(C=C1)C(=O)NCCN)C=C(S2)C(=N)N Stabilizer C13H16N4O2S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-U4C9C5 K8W 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide; K8W CC1=C(N=C(C=C1)C2=CC=CC3=C2SC(=C3)C(=N)N)N Stabilizer C15H14N4S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-3JC22A K92 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide; K92 C1=CC=C(C=C1)C2=C(SC(=C2)C(=N)N)C3=CN=CN3CCN Stabilizer C16H17N5S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-KL1NM2 KDK 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide C1CNCCC1CC2=C(C=C(S2)C(=N)N)C3=CC=CC=C3 Stabilizer C17H21N3S 14-3-3σ;TAZ P31947/Q9GZV5 . 10.1021/acs.jmedchem.9b01942 TPD-B63POJ KLZ 4-chloranyl-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide; PD195542; KLZ C1=C(C=C(C2=C1SC(=C2)C(=N)N)Cl)CS Stabilizer C10H9ClN2S2 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-F3C7WG KM8 . CCC(=O)NC1=CC=CC(=C1)C2=CSC(=C2)C(=N)N Stabilizer C14H15N3OS 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-CW3SCL L1T 4-methyl-5-phenyl-thiophene-2-carboximidamide; L1T CC1=C(SC(=C1)C(=N)N)C2=CC=CC=C2 Stabilizer C12H12N2S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-HQSPZL K65 K65 C=CC(=O)NC1=CC=CC=C1C2=CSC(=C2)C(=N)N Stabilizer C14H13N3OS 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-MOX34U LFQ 5-methyl-4-phenyl-thiophene-2-carboximidamide; LFQ CC1=C(C=C(S1)C(=N)N)C2=CC=CC=C2 Stabilizer C12H12N2S 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-03ZH1D LFB 7-methoxy-1-benzothiophene-2-carboximidamide; LFB COC1=CC=CC2=C1SC(=C2)C(=N)N Stabilizer C10H10N2OS 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-7VHRCE LF5 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide; LF5 CC(C)OC1=C2C(=C(C=C1)Cl)C=C(S2)C(=N)N Stabilizer C12H13ClN2OS 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-CYXJGS LJW 4-(methylamino)-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide; LJW CC(C)OC1=C2C(=C(C=C1)NC)C=C(S2)C(=N)N Stabilizer C13H17N3OS 14-3-3σ;p53 P31947/P04637 . 10.1021/acs.jmedchem.9b01942 TPD-1D64R9 SCHEMBL22685506 2-(4-tert-butylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C24H25N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-I1CLO5 SCHEMBL22685486 2-(4-tert-butylphenyl)-N-[[2-[(3S)-2,7-dioxoazepan-3-yl]-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488366 CC(C)(C)C1=CC=C(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N([C@H]2CCCC(=O)NC2=O)C3)C=C1 Degrader C27H29N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-88TUDG SCHEMBL22685561 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-(3-fluorophenyl)-2-oxoacetamide; SCHEMBL29488395 O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(=O)C4=CC(F)=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C22H18FN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-OH5EGG SCHEMBL22685672 2-(3,4-dichlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(Cl)C(Cl)=C3)C2=O)C(=O)N1 Degrader C22H17Cl2N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-PWS01U SCHEMBL22685712 2-(3,4-dichlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488384 O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(=O)C4=CC(Cl)=C(Cl)C=C4)=C/3)C2=O)C(=O)N1 Degrader C22H17Cl2N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-0XGXGD SCHEMBL22685481 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-pyridin-4-ylacetamide O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(=O)C4=CC=NC=C4)=C/3)C2=O)C(=O)N1 Degrader C21H18N4O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-0SPC34 SCHEMBL22685586 2-(4-tert-butyl-2,6-dimethylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488378 CC1=CC(C(C)(C)C)=CC(C)=C1C(=O)C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C28H31N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-WJG4XA SCHEMBL22685698 2-(4-tert-butyl-2,6-dimethylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC1=CC(C(C)(C)C)=CC(C)=C1C(=O)C(=O)NCC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O Degrader C28H31N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-VSM2ZA SCHEMBL22685715 2-(4-bromophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(Br)C=C3)C2=O)C(=O)N1 Degrader C22H18BrN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-T6VAYX SCHEMBL22685649 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-(4-methoxyphenyl)-2-oxoacetamide COC1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C21H19N3O6S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-9MDN3M SCHEMBL22685812 2-(4-cyclopropylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=C(C5CC5)C=C4)SC=C3C2=O)C(=O)N1 Degrader C23H21N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-HTOE4A SCHEMBL22685554 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-(4-propan-2-ylphenyl)acetamide CC(C)C1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C23H23N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-RSY1ZG SCHEMBL22685828 2-(4-butan-2-ylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide CCC(C)C1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C24H25N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-8QX0HD SCHEMBL22685599 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-(4-hydroxyphenyl)-2-oxoacetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=C(O)C=C4)SC=C3C2=O)C(=O)N1 Degrader C20H17N3O6S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-MN0CG5 SCHEMBL22685807 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-(4-methylphenyl)-2-oxoacetamide CC1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C21H19N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-RQZLCF SCHEMBL22685626 2-(4-chlorophenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=C(Cl)C=C4)SC=C3C2=O)C(=O)N1 Degrader C20H16ClN3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-34IDI9 SCHEMBL22685689 2-(3-tert-butylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=CC(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)=C1 Degrader C24H25N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-4CU130 SCHEMBL22685786 2-(4-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488352 CC(C)(C)C1=CC=C(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C26H27N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-CZCKQE US20200369679A1_1-20 . CC(=O)NC1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C22H20N4O6S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-L5SAJD SCHEMBL22685455 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-(4-phenylphenyl)acetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=C(C5=CC=CC=C5)C=C4)SC=C3C2=O)C(=O)N1 Degrader C26H21N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-CR19GY SCHEMBL22685623 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-(4-fluorophenyl)-2-oxoacetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=C(F)C=C4)SC=C3C2=O)C(=O)N1 Degrader C20H16FN3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-PND18P SCHEMBL22685595 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-[4-(trifluoromethyl)phenyl]acetamide; WIXJHLAEXABRLP-UHFFFAOYSA-N; N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-[4-(trifluoromethyl)phenyl]acetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=C(C(F)(F)F)C=C4)SC=C3C2=O)C(=O)N1 Degrader C21H16F3N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-2PHCI0 SCHEMBL22685669 2-(3,4-dichlorophenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC(Cl)=C(Cl)C=C4)SC=C3C2=O)C(=O)N1 Degrader C20H15Cl2N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-9ZOM0M SCHEMBL22685763 2-[4-[(dimethylamino)methyl]phenyl]-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide CN(C)CC1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C23H24N4O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-MDHIG0 SCHEMBL22685549 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-[4-(morpholin-4-ylmethyl)phenyl]-2-oxoacetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=C(CN5CCOCC5)C=C4)SC=C3C2=O)C(=O)N1 Degrader C25H26N4O6S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-6TLNFV SCHEMBL22685500 2-(4-tert-butyl-3-methylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide CC1=C(C(C)(C)C)C=CC(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)=C1 Degrader C25H27N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-PN28KY SCHEMBL22685781 2-(4-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C26H27N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-BQIPD0 SCHEMBL22685664 2-(4-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NCC2=CC(F)=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C26H26FN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-67UXU2 SCHEMBL22685474 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide; IMGFKGNBOZHWFE-UHFFFAOYSA-N; N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=C(C5(C(F)(F)F)CC5)C=C4)SC=C3C2=O)C(=O)N1 Degrader C24H20F3N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-QI1202 SCHEMBL22685753 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide; ISFHFFKINJCNJC-UHFFFAOYSA-N; N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(C4(C(F)(F)F)CC4)C=C3)C2=O)C(=O)N1 Degrader C26H22F3N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-Y8VLYY SCHEMBL22685552 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-[4-(1-methylpiperidin-4-yl)phenyl]-2-oxoacetamide CN1CCC(C2=CC=C(C(=O)C(=O)NCC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CS3)C=C2)CC1 Degrader C26H28N4O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-BJCB8I SCHEMBL22685751 2-(4-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488386 CC(C)(C)C1=CC=C(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C26H25N3O6 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-HSEK6K SCHEMBL22685663 2-(3-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488400 CC(C)(C)C1=CC=CC(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)=C1 Degrader C26H27N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-GWFS7E SCHEMBL22685513 2-(4-tert-butylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[2,3-c]pyrrol-2-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NC/C2=C/C3=C(S2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C24H25N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-TNHFG7 SCHEMBL22685798 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-[4-(1,1,1-trifluoropropan-2-yl)phenyl]acetamide; QRGLRLSSUAKKPH-UHFFFAOYSA-N; N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-[4-(1,1,1-trifluoropropan-2-yl)phenyl]acetamide CC(C1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1)C(F)(F)F Degrader C23H20F3N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-E4WV5Q SCHEMBL22685465 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-(5-propan-2-ylthiophen-2-yl)acetamide CC(C)C1=CC=C(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)S1 Degrader C23H23N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-7AB86Z SCHEMBL22685754 2-(4-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-4-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NC/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C26H27N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-X2ENH2 SCHEMBL22685625 2-(4-tert-butylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[2,3-c]pyrrol-3-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NC/C2=C/SC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C24H25N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-1JBG51 SCHEMBL22685691 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-(5-propan-2-ylthiophen-2-yl)acetamide CC(C)C1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)S1 Degrader C21H21N3O5S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-DJLVIN US20200369679A1_1-40 . CN(C/C1=C/SC2=C1CN(C1CCC(=O)NC1=O)C2=O)C(=O)C(=O)C1=CC=C(C(C)(C)C)C=C1 Degrader C25H27N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-HMFP4U SCHEMBL22685813 2-(4-tert-butylphenyl)-N-[2-[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]ethyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NCC/C2=C3\CN(C4CCC(=O)NC4=O)C(=O)\C3=C\S2)C=C1 Degrader C25H27N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-OMMEGW SCHEMBL22685536 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-[4-(1-methylcyclopropyl)phenyl]-2-oxoacetamide CC1(C2=CC=C(C(=O)C(=O)NCC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CS3)C=C2)CC1 Degrader C24H23N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-FZTDZL SCHEMBL22685641 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-2-oxoacetamide CC(C)(CO)C1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C24H25N3O6S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-RXTXG7 SCHEMBL22685662 2-[3-(dimethylamino)-4-methylphenyl]-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide CC1=C(N(C)C)C=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C23H24N4O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-KX4A7I SCHEMBL22699797 2-(4-tert-butylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-4-oxo-6H-thieno[2,3-c]pyrrol-2-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NCC2=CC3=C(CN(C4CCC(=O)NC4=O)C3=O)S2)C=C1 Degrader C24H25N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-MIV4Y4 SCHEMBL22685720 2-(3-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC=C1 Degrader C26H27N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-JL0YEH SCHEMBL22685714 2-(4-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-N-methyl-2-oxoacetamide CN(CC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)C(=O)C(=O)C1=CC=C(C(C)(C)C)C=C1 Degrader C27H29N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-5R3K29 SCHEMBL22685510 [3-[7-[[[2-(4-tert-butylphenyl)-2-oxoacetyl]amino]methyl]-3-oxo-1H-isoindol-2-yl]-2,6-dioxopiperidin-1-yl]methyl (2R)-2-amino-3-methylbutanoate; SCHEMBL29488357 CC(C)[C@@H](N)C(=O)OCN1C(=O)CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(C(C)(C)C)C=C3)C2=O)C1=O Degrader C32H38N4O7 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-U43SG4 Sontigidomide Sontigidomide; 2560577-69-5; Sontigidomida; sontigidomide [INN]; FDD2NVW84X; orb1943636; CHEMBL5314540; SCHEMBL22685741; SKAIDPMCBUKTDS-UHFFFAOYSA-N; DA-77941; HY-156641; CS-0886824; Benzeneacetamide, N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-alpha-oxo-4-[1-(trifluoromethyl)cyclopropyl]-; N-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-alpha-oxo-4-[1-(trifluoromethyl)cyclopropyl]benzeneacetamide; N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide O=C1CCC(N2CC3=C(C=CC(CNC(=O)C(=O)C4=CC=C(C5(C(F)(F)F)CC5)C=C4)=C3)C2=O)C(=O)N1 Degrader C26H22F3N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-09HEC7 SCHEMBL22685630 2-(4-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-5-fluoro-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NCC2=C(F)C=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C26H26FN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-FBRZ0L SCHEMBL22685761 2-(4-tert-butylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-5,6-difluoro-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NCC2=C(F)C(F)=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C26H25F2N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-0RDGHA SCHEMBL22685463 N-[2-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]ethyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide; MUHAWBAOZSMGKD-UHFFFAOYSA-N; N-[2-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]ethyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide O=C1CCC(N2CC3=C(/C=C\C(CCNC(=O)C(=O)C4=CC=C(C5(C(F)(F)F)CC5)C=C4)=C/3)C2=O)C(=O)N1 Degrader C27H24F3N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-B7B7AO SCHEMBL22685614 2-(3-chloro-4-methylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488391 CC1=C(Cl)C=C(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C23H20ClN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-PSEQHH SCHEMBL22685546 2-(4-tert-butyl-3-methylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC1=CC(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC=C1C(C)(C)C Degrader C27H29N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-Z6WNLN SCHEMBL22685670 2-(4-tert-butyl-3-methylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488396 CC1=C(C(C)(C)C)C=CC(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)=C1 Degrader C27H29N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-R3SW4Y SCHEMBL22685679 2-(4-tert-butylphenyl)-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]-2-oxoacetamide CC(C)(C)C1=CC=C(C(=O)C(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C25H25N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-0VPTW0 SCHEMBL22685483 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide; MACMVYAZBJFSDS-UHFFFAOYSA-N; N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide O=C1CCC(N2CC3=C(C=CC=C3NC(=O)C(=O)C3=CC=C(C4(C(F)(F)F)CC4)C=C3)C2=O)C(=O)N1 Degrader C25H20F3N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-TJWSGB SCHEMBL22685628 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxo-2-(5-propan-2-ylthiophen-2-yl)acetamide CC(C)C1=CC=C(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)S1 Degrader C23H23N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-HLSGM2 SCHEMBL22685680 2-(3-chloro-4-methylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide CC1=C(Cl)C=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C21H18ClN3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-C05V63 SCHEMBL22685652 N-[[2-(2,6-dioxopiperidin-3-yl)-4-methyl-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide; WMYWVABMTRLUSP-UHFFFAOYSA-N; N-[[2-(2,6-dioxopiperidin-3-yl)-4-methyl-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide CC1=C(CNC(=O)C(=O)C2=CC=C(C3(C(F)(F)F)CC3)C=C2)C=CC2=C1CN(C1CCC(=O)NC1=O)C2=O Degrader C27H24F3N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-UJQ3E3 SCHEMBL22685585 2-(4-tert-butylpiperidin-1-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC(C)(C)C1CCN(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C25H32N4O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-IQ63MI SCHEMBL22685723 2-(4-tert-butylpiperidin-1-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488354 CC(C)(C)C1CCN(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)CC1 Degrader C25H32N4O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-WOR9YW SCHEMBL22685601 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]propanamide; AHQIWKLPWIVQKS-UHFFFAOYSA-N; N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]propanamide O=C1CCC(N2CC3=C(C=CC(CNC(=O)C(=O)CC4=CC=C(C5(C(F)(F)F)CC5)C=C4)=C3)C2=O)C(=O)N1 Degrader C27H24F3N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-1R7V48 SCHEMBL22699795 [2,6-dioxo-3-[3-oxo-7-[[[2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetyl]amino]methyl]-1H-isoindol-2-yl]piperidin-1-yl]methyl (2R)-2-amino-3-methylbutanoate; SCHEMBL29488347 CC(C)[C@@H](N)C(=O)OCN1C(=O)CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(C4(C(F)(F)F)CC4)C=C3)C2=O)C1=O Degrader C32H33F3N4O7 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-B60A55 SCHEMBL22685525 N-[2-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]ethyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide; GUSQVMPOEZWTEN-UHFFFAOYSA-N; N-[2-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]ethyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide O=C1CCC(N2CC3=C(C=CC=C3CCNC(=O)C(=O)C3=CC=C(C4(C(F)(F)F)CC4)C=C3)C2=O)C(=O)N1 Degrader C27H24F3N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-7AUB9I SCHEMBL22685654 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxo-2-(4-piperidin-4-ylphenyl)acetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(C4CCNCC4)C=C3)C2=O)C(=O)N1 Degrader C27H28N4O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-GYP0U7 SCHEMBL22685756 2-(4-tert-butylcyclohexyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC(C)(C)C1CCC(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C26H33N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-2W8NRK SCHEMBL22685819 2-(4-tert-butylcyclohexyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488373 CC(C)(C)C1CCC(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)CC1 Degrader C26H33N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-J5ORNU SCHEMBL22685666 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[2,3-c]pyrrol-2-yl]methyl]-2-oxo-4-phenylbutanamide O=C1CCC(N2CC3=C(S/C(CNC(=O)C(=O)CCC4=CC=CC=C4)=C\3)C2=O)C(=O)N1 Degrader C22H21N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-3Y0GMM SCHEMBL22685461 2-[4-(dimethylamino)phenyl]-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxoacetamide CN(C)C1=CC=C(C(=O)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C22H22N4O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-I09DZM SCHEMBL22685667 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-N',N'-dimethyloxamide CN(C)C(=O)C(=O)NCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CS1 Degrader C16H18N4O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-ELVVHX SCHEMBL22685752 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[2,3-c]pyrrol-2-yl]methyl]-N',N'-dimethyloxamide CN(C)C(=O)C(=O)NCC1=CC2=C(S1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C16H18N4O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-KF9V38 SCHEMBL22685470 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-(4-methylphenyl)-2-oxoacetamide CC1=CC=C(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C23H21N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-K5SZTK SCHEMBL22685589 2-(3,4-difluorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(F)C(F)=C3)C2=O)C(=O)N1 Degrader C22H17F2N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-B52SP7 SCHEMBL22685668 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxo-2-phenylacetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=CC=C3)C2=O)C(=O)N1 Degrader C22H19N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-JYGYAV SCHEMBL22685519 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxo-2-[4-(trifluoromethyl)phenyl]acetamide; CEFRADKDQPLKPO-UHFFFAOYSA-N; N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxo-2-[4-(trifluoromethyl)phenyl]acetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(C(F)(F)F)C=C3)C2=O)C(=O)N1 Degrader C23H18F3N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-O6FSG3 SCHEMBL22685817 2-(4-cyanophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide N#CC1=CC=C(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C23H18N4O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-ZJAST4 SCHEMBL22685566 2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(Cl)C=C3)C2=O)C(=O)N1 Degrader C22H18ClN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-HEINHJ SCHEMBL22685619 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-(4-methoxyphenyl)-2-oxoacetamide COC1=CC=C(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C23H21N3O6 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-J32W5G SCHEMBL22685542 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxo-2-(2,4,6-trimethoxyphenyl)acetamide COC1=CC(OC)=C(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C(OC)=C1 Degrader C25H25N3O8 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-PEZEHY SCHEMBL22685541 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-phenylacetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=CC=C4)SC=C3C2=O)C(=O)N1 Degrader C20H17N3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-TBH0V9 SCHEMBL22685624 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxo-2-(2,4,6-trimethylphenyl)acetamide CC1=CC(C)=C(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C(C)=C1 Degrader C25H25N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-22CZI1 SCHEMBL22685743 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-(4-fluorophenyl)-2-oxoacetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=C(F)C=C3)C2=O)C(=O)N1 Degrader C22H18FN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-IORT80 SCHEMBL22685776 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-(2-fluorophenyl)-2-oxoacetamide; SCHEMBL29488346 O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=CC=C3F)C2=O)C(=O)N1 Degrader C22H18FN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-AWVJT7 CHEMBL4787201 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-phenylacetamide; SCHEMBL22685705 O=C1CCC(N2CC3=C(C=CC(CNC(=O)C(=O)C4=CC=CC=C4)=C3)C2=O)C(=O)N1 Degrader C22H19N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-AZDLJY SCHEMBL22685456 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-(2,4,6-trimethoxyphenyl)acetamide COC1=CC(OC)=C(C(=O)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)C(OC)=C1 Degrader C25H25N3O8 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-W3K53V SCHEMBL22685588 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-(2,4,6-trimethylphenyl)acetamide CC1=CC(C)=C(C(=O)C(=O)NCC2=C/C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C(C)=C1 Degrader C25H25N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-CS6068 SCHEMBL22685675 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-(2-fluorophenyl)-2-oxoacetamide; SCHEMBL29488371 O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(=O)C4=C(F)C=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C22H18FN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-31MSWP SCHEMBL22685560 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-[4-(trifluoromethyl)phenyl]acetamide; SINPUUWRHUGTDN-UHFFFAOYSA-N; N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-[4-(trifluoromethyl)phenyl]acetamide O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(=O)C4=CC=C(C(F)(F)F)C=C4)=C/3)C2=O)C(=O)N1 Degrader C23H18F3N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-PLX1P2 SCHEMBL22685810 2-(3-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=CC(Cl)=C3)C2=O)C(=O)N1 Degrader C22H18ClN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-WXVN72 SCHEMBL22685757 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-(4-methoxyphenyl)-2-oxoacetamide COC1=CC=C(C(=O)C(=O)NCC2=C/C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C23H21N3O6 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-B0K4S1 SCHEMBL22685596 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-oxo-2-thiophen-2-ylacetamide O=C1CCC(N2CC3=C(CNC(=O)C(=O)C4=CC=CS4)SC=C3C2=O)C(=O)N1 Degrader C18H15N3O5S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-PS1RE2 SCHEMBL22685559 2-(4-cyanophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488372 N#CC1=CC=C(C(=O)C(=O)NCC2=C/C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C23H18N4O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-78BRR2 SCHEMBL22685811 2-(3-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488375 O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(=O)C4=CC(Cl)=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C22H18ClN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-Q77D0T SCHEMBL22685796 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-(3-fluorophenyl)-2-oxoacetamide O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=CC=CC(F)=C3)C2=O)C(=O)N1 Degrader C22H18FN3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-M4EOEU SCHEMBL22685780 2-(3,4-difluorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488387 O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(=O)C4=CC(F)=C(F)C=C4)=C/3)C2=O)C(=O)N1 Degrader C22H17F2N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-2JYEBQ SCHEMBL22685568 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-(3-methoxyphenyl)-2-oxoacetamide COC1=CC(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC=C1 Degrader C23H21N3O6 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-LUPK2L SCHEMBL22685497 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-(3-methoxyphenyl)-2-oxoacetamide; SCHEMBL29488351 COC1=CC=CC(C(=O)C(=O)NCC2=C/C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)=C1 Degrader C23H21N3O6 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-WEJ29J SCHEMBL22685764 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-naphthalen-2-yl-2-oxoacetamide; SCHEMBL29488380 O=C1CCC(N2CC3=C(C=CC=C3CNC(=O)C(=O)C3=C\C=C4\C=CC=C\C4=C\3)C2=O)C(=O)N1 Degrader C26H21N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-CEMUGQ SCHEMBL22685479 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-naphthalen-2-yl-2-oxoacetamide; SCHEMBL29488360 O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(=O)C4=C/C5=C(C=CC=C5)/C=C\4)=C/3)C2=O)C(=O)N1 Degrader C26H21N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-O924Z9 SCHEMBL22685505 2-(3,5-dimethylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-2-oxoacetamide CC1=CC(C)=CC(C(=O)C(=O)NCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=C1 Degrader C24H23N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-7SHZDG SCHEMBL22685562 2-(3,5-dimethylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxoacetamide; SCHEMBL29488356 CC1=CC(C)=CC(C(=O)C(=O)NCC2=C/C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)=C1 Degrader C24H23N3O5 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-48G27T SCHEMBL22685816 1-[3-(dimethylamino)-4-methylphenyl]-3-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[2,3-c]pyrrol-2-yl]methyl]urea CC1=C(N(C)C)C=C(NC(=O)NC/C2=C/C3=C(S2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C22H25N5O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-O0OLNA SCHEMBL20263414 1-(3-chloro-4-methylphenyl)-3-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]urea CC1=C(Cl)C=C(NC(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C20H19ClN4O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-PAK2O0 SCHEMBL22685538 1-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[2,3-c]pyrrol-2-yl]methyl]-3-[3-[ethyl(methyl)amino]-4-methylphenyl]urea; SCHEMBL29488381 CCN(C)C1=C(C)C=CC(NC(=O)NC/C2=C/C3=C(S2)C(=O)N(C2CCC(=O)NC2=O)C3)=C1 Degrader C23H27N5O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-6B9Q68 SCHEMBL22685583 4-(3-chloro-4-methylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-methylbutanamide CC1=C(Cl)C=C(CCC(C)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C24H26ClN3O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-NDZ0WH SCHEMBL22685700 (2S)-2-(3-chloro-4-methylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]propanamide CC1=C(Cl)C=C([C@H](C)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C22H22ClN3O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-GCUE4P SCHEMBL22685604 (2R)-2-(3-chloro-4-methylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]propanamide CC1=C(Cl)C=C([C@@H](C)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C22H22ClN3O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-W9IWG3 SCHEMBL22685674 4-(3-chloro-4-methylphenyl)-N-[[5-[(3S)-2,6-dioxopiperidin-3-yl]-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2,2-dimethylbutanamide CC1=C(Cl)C=C(CCC(C)(C)C(=O)NCC2=C3CN([C@H]4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C25H28ClN3O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-G8GRLH SCHEMBL22685469 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-3-methyl-2-(4-propan-2-ylphenyl)butanamide CC(C)C1=CC=C(C(C(=O)NC/C2=C3\CN(C4CCC(=O)NC4=O)C(=O)\C3=C\S2)C(C)C)C=C1 Degrader C26H31N3O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-TC1CB6 SCHEMBL22685644 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[2,3-c]pyrrol-2-yl]methyl]-2-(2,3,4,5,6-pentafluorophenyl)acetamide O=C(CC1=C(F)C(F)=C(F)C(F)=C1F)NC/C1=C/C2=C(S1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C20H14F5N3O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-9N4689 SCHEMBL22699787 2-(dimethylamino)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-(2-fluorophenyl)acetamide CN(C)C(C(=O)NC/C1=C2\CN(C3CCC(=O)NC3=O)C(=O)\C2=C\S1)C1=C(F)C=CC=C1 Degrader C22H23FN4O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-IP1Z14 SCHEMBL22685653 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-4-phenylbutanamide O=C(CCCC1=CC=CC=C1)NCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CS1 Degrader C22H23N3O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-GRAR38 SCHEMBL22685769 1-[3-(dimethylamino)-4-methylphenyl]-3-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]urea CC1=C(N(C)C)C=C(NC(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C22H25N5O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-8AQ9VG SCHEMBL22685718 1-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[2,3-c]pyrrol-2-yl]methyl]-3-phenylthiourea O=C1CCC(N2CC3=C(S/C(CNC(=S)NC4=CC=CC=C4)=C\3)C2=O)C(=O)N1 Degrader C19H18N4O3S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-Y1KL2I SCHEMBL22685453 1-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-3-[4-(trifluoromethoxy)phenyl]thiourea; OAYCXXXCYHDLEL-UHFFFAOYSA-N; 1-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-3-[4-(trifluoromethoxy)phenyl]thiourea O=C1CCC(N2CC3=C(CNC(=S)NC4=CC=C(OC(F)(F)F)C=C4)SC=C3C2=O)C(=O)N1 Degrader C20H17F3N4O4S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-U2FN9Y SCHEMBL22685597 2-amino-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-(4-propoxyphenyl)acetamide CCCOC1=CC=C(C(N)C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C23H26N4O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-4JD6VJ SCHEMBL22685594 2-amino-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-(4-hydroxyphenyl)acetamide NC(C(=O)NCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CS1)C1=CC=C(O)C=C1 Degrader C20H20N4O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-2BAV7P SCHEMBL22685627 1-[3-(Dimethylamino)-4-methylphenyl]-3-[[5-(2,6-dioxopiperidin-3-yl)-4,6-dioxothieno[2,3-c]pyrrol-2-yl]methyl]urea CC1=C(N(C)C)C=C(NC(=O)NC/C2=C/C3=C(S2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C22H23N5O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-WQGS3J SCHEMBL22685639 4-[4-(dimethylamino)-3-methylphenyl]-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]butanamide; SCHEMBL29488370 CC1=CC(CCCC(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)=CC=C1N(C)C Degrader C25H30N4O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-F4UCUJ SCHEMBL22685725 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[2,3-c]pyrrol-2-yl]methyl]-2-(3-fluoro-2-methoxyphenyl)acetamide; SCHEMBL29488369 COC1=C(CC(=O)NC/C2=C/C3=C(S2)C(=O)N(C2CCC(=O)NC2=O)C3)C=CC=C1F Degrader C21H20FN3O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-K2ASHO SCHEMBL22685530 4-bromo-2,5-dichloro-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]thiophene-3-sulfonamide O=C1CCC(N2CC3=C(CNS(=O)(=O)C4=C(Cl)SC(Cl)=C4Br)SC=C3C2=O)C(=O)N1 Degrader C16H12BrCl2N3O5S3 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-FGV1YW SCHEMBL22685829 methyl 5-chloro-3-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methylsulfamoyl]thiophene-2-carboxylate COC(=O)C1=C(S(=O)(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C(Cl)S1 Degrader C18H16ClN3O7S3 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-JGF7LY SCHEMBL22685800 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-4-methylthiadiazole-5-carboxamide CC1=C(C(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)SN=N1 Degrader C16H15N5O4S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-2LPM3S SCHEMBL22685701 N-[5-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methylcarbamoylamino]-2-methylphenyl]acetamide CC(=O)NC1=C(C)C=CC(NC(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)=C1 Degrader C22H23N5O5S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-LUSK24 SCHEMBL22685472 N-[5-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methylsulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide CC(=O)NC1=NC(C)=C(S(=O)(=O)NC/C2=C3\CN(C4CCC(=O)NC4=O)C(=O)\C3=C\S2)S1 Degrader C18H19N5O6S3 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-5LBZ52 SCHEMBL22685532 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2,3,4,5,6-pentafluorobenzenesulfonamide O=C1CCC(N2CC3=C(CNS(=O)(=O)C4=C(F)C(F)=C(F)C(F)=C4F)SC=C3C2=O)C(=O)N1 Degrader C18H12F5N3O5S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-HUP5X7 SCHEMBL22685721 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-1-methylimidazole-4-sulfonamide CN1C=NC(S(=O)(=O)NC/C2=C3\CN(C4CCC(=O)NC4=O)C(=O)\C3=C\S2)=C1 Degrader C16H17N5O5S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-6AV78L SCHEMBL22685688 1-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-3-(2,3,5,6-tetrachlorophenyl)thiourea O=C1CCC(N2CC3=C(CNC(=S)NC4=C(Cl)C(Cl)=CC(Cl)=C4Cl)SC=C3C2=O)C(=O)N1 Degrader C19H14Cl4N4O3S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-QWEF2N SCHEMBL22685528 4-tert-butyl-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]benzenesulfonamide CC(C)(C)C1=CC=C(S(=O)(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=C1 Degrader C22H25N3O5S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-XP6U6S SCHEMBL22685496 methyl 3-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methylcarbamoylamino]thiophene-2-carboxylate COC(=O)C1=C(NC(=O)NCC2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CS2)C=CS1 Degrader C19H18N4O6S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-PK59R0 SCHEMBL22685490 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-1,3-thiazole-2-carboxamide O=C1CCC(N2CC3=C(\CNC(=O)C4=NC=CS4)S/C=C\3C2=O)C(=O)N1 Degrader C16H14N4O4S2 IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-1OPKQC SCHEMBL22685451 1-(4-tert-butylphenyl)-N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]cyclopropane-1-carboxamide CC(C)(C)C1=CC=C(C2(C(=O)NCC3=C4CN(C5CCC(=O)NC5=O)C(=O)C4=CS3)CC2)C=C1 Degrader C26H29N3O4S IKZF1;CK1α;GSPT1 Q13422/P48729/P15170 CRBN US-20200369679-A1 TPD-4M8RC9 Trametinib Trametinib; 871700-17-3; TMT212; trametinibum; UNII-33E86K87QN; CHEBI:75998; TMT-212; 33E86K87QN; MEK Inhibitor GSK1120212; L01XE25; GSK1120212; Mekinist; GSK-1120212; JTP 74057; Trametinib (GSK1120212); JTP-74057; GSK 1120212; N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; Trametinib [USAN]; MFCD17215075; N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide; N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide; Trametinib (USAN); N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide; Trametinib [USAN:INN]; Trametinib?; JTP74057; N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)acetamide; N-(3-{3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl}phenyl)acetamide; N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; QOM; Trametinib (Standard); TRAMETINIB [MI]; TRAMETINIB [INN]; TRAMETINIB [VANDF]; TRAMETINIB [WHO-DD]; SCHEMBL170938; GTPL6495; GSK1120212 (Trametinib); CHEMBL2103875; EX-A022; LIRYPHYGHXZJBZ-UHFFFAOYSA-N; BCPP000218; DTXSID901007381; HMS3295I05; HMS3656J11; HMS5081N13; BCP02307; BDBM50531540; HY-10999R; NSC758246; NSC800956; s2673; AKOS015850628; CCG-264976; CS-0060; DB08911; EX-5957; FC34128; NSC-758246; NSC-800956; SB16553; SDCCGSBI-0646933.P001; NCGC00263180-01; NCGC00263180-07; NCGC00263180-14; AC-25891; AS-19382; HY-10999; N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodo-anilino)-6,8-dimethyl-2,4,7-trioxo-pyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide; SY067882; NS00040692; SW218089-2; D10175; EN300-25299821; GSK1120212,JTP-74057, GSK212; SR-01000941589; Q7833138; SR-01000941589-1; BRD-K12343256-001-01-4; BRD-K12343256-001-08-9; BRD-K12343256-001-11-3; BRD-K12343256-001-14-7; BRD-K12343256-001-18-8; Acetamide, N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-3,4,6,7-tetrahydro-6,8- dimethyl-2,4,7-trioxopyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)-; Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-; N-(3-(3-Cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)pheny l)acetamide; N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide; N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-1H,2H,3H,4H,6H,7H-pyrido[4,3-d]pyrimidin-1-yl}phenyl)acetamide; N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxopyrido[3,4-e]pyrimidin-1-yl]phenyl]acetamide; N-{3-[3-Cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl}ethanimidic acid; N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1 Stabilizer C26H23FIN5O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-LIGAP1 US20230381180-A1_10 . CCC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(CC)c(=O)c(CC)c32)c1 Stabilizer C29H29FIN5O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-ZBNEFJ SCHEMBL24145926 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2,2-dimethylpropanamide\; SCHEMBL24145926 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)C(C)(C)C)c3)c12 Stabilizer C29H29FIN5O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-ZD8VFK SCHEMBL24146268 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2,2,3,3,4,4,4-heptafluorobutanamide\; SCHEMBL24146268 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)C(F)(F)C(F)(F)C(F)(F)F)c3)c12 Stabilizer C28H20F8IN5O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-FCBTA4 SCHEMBL24145871 2-[3-[3-Cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]guanidine\; SCHEMBL24145871 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=N)N)c3)c12 Stabilizer C25H23FIN7O3 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-THCA0I SCHEMBL24146304 1-Cyclopropyl-3-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]urea\; SCHEMBL24146304 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)NC4CC4)c3)c12 Stabilizer C28H26FIN6O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-Y4FKUW US20230381180-A1_15 . CCc1c(=O)n(CC)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NS(=O)(=O)CC)c3)c12 Stabilizer C28H29FIN5O5S BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-RHL1U5 SCHEMBL24146269 N'-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-N,N-dimethylmethanimidamide\; SCHEMBL24146269 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(/N=C/N(C)C)c3)c12 Stabilizer C27H26FIN6O3 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-NUB3HE SCHEMBL24145884 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]pyrrolidine-1-sulfonamide\; SCHEMBL24145884 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NS(=O)(=O)N4CCCC4)c3)c12 Stabilizer C28H28FIN6O5S BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-PJHKVU US20230381180-A1_18 . CCCCS(=O)(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1 Stabilizer C28H29FIN5O5S BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-8HMZ3R SCHEMBL24146120 3-amino-N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]azetidine-1-sulfonamide\; SCHEMBL24146120 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NS(=O)(=O)N4CC(N)C4)c3)c12 Stabilizer C27H27FIN7O5S BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-Z2Z0KO Trametiglue Trametiglue; 2666940-97-0; N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)-N'-methylsulfuric diamide; VKG; SCHEMBL24146294; EX-A11339; DA-58689; HY-153181; CS-0654032; H40468; 3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-1-[3-(methylsulfamoylamino)phenyl]pyrido[4,3-d]pyrimidine-2,4,7-trione CNS(=O)(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1 Stabilizer C25H24FIN6O5S BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-RUKV16 SCHEMBL13164266 3-amino-N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]propanamide\; SCHEMBL13164266 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)CCN)c3)c12 Stabilizer C27H26FIN6O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-Y7VABJ SCHEMBL26017594 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]prop-2-enamide\; SCHEMBL26017594 C=CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1 Stabilizer C27H23FIN5O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-M7HZCU SCHEMBL25363082 2-bromo-N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide\; SCHEMBL25363082 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)CBr)c3)c12 Stabilizer C26H22BrFIN5O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-58MJOY SCHEMBL26017600 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2-piperidin-1-ylacetamide\; SCHEMBL26017600 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)CN4CCCCC4)c3)c12 Stabilizer C31H32FIN6O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-PP5J1D US20230381180-A1_24 . Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)CN4CCN(C)CC4)c3)c12 Stabilizer C31H33FIN7O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-827N03 US20230381180-A1_25 . Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)CNNN)c3)c12 Stabilizer C26H26FIN8O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-3F5865 SCHEMBL26017609 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2-(4-phenyltriazol-1-yl)acetamide\; SCHEMBL26017609 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)Cn4cc(-c5ccccc5)nn4)c3)c12 Stabilizer C34H28FIN8O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-GP1OUJ US20230381180-A1_27 . Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)Cn4ccnn4)c3)c12 Stabilizer C28H24FIN8O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-MVZ1H7 SCHEMBL26017614 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2-[4-(4-methylphenyl)triazol-1-yl]acetamide\; SCHEMBL26017614 Cc1ccc(-c2cn(CC(=O)Nc3cccc(-n4c(=O)n(C5CC5)c(=O)c5c(Nc6ccc(I)cc6F)n(C)c(=O)c(C)c54)c3)nn2)cc1 Stabilizer C35H30FIN8O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-1RINQ0 SCHEMBL26017615 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2-[4-(4-methoxyphenyl)triazol-1-yl]acetamide\; SCHEMBL26017615 COc1ccc(-c2cn(CC(=O)Nc3cccc(-n4c(=O)n(C5CC5)c(=O)c5c(Nc6ccc(I)cc6F)n(C)c(=O)c(C)c54)c3)nn2)cc1 Stabilizer C35H30FIN8O5 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-8LWWIB SCHEMBL24146279 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2,2,2-trifluoroacetamide\; SCHEMBL24146279 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)C(F)(F)F)c3)c12 Stabilizer C26H20F4IN5O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-LPG0NH SCHEMBL25363922 3-Cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-1-[3-(pyrimidin-2-ylamino)phenyl]pyrido[4,3-d]pyrimidine-2,4,7-trione\; SCHEMBL25363922 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(Nc4ncccn4)c3)c12 Stabilizer C28H23FIN7O3 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-WKBATG SCHEMBL25365297 3-Cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-1-[3-(pyridin-2-ylamino)phenyl]pyrido[4,3-d]pyrimidine-2,4,7-trione\; SCHEMBL25365297 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(Nc4ccccn4)c3)c12 Stabilizer C29H24FIN6O3 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-R8KYUG SCHEMBL26017622 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2-piperazin-1-ylacetamide\; SCHEMBL26017622 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)CN4CCNCC4)c3)c12 Stabilizer C30H31FIN7O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-ZM19MS SCHEMBL26017625 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]acetamide\; SCHEMBL26017625 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)Cn4cc(-c5ccc(C(F)(F)F)cc5)nn4)c3)c12 Stabilizer C35H27F4IN8O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-IX37R3 SCHEMBL26017632 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2-[4-(3-hydroxyphenyl)triazol-1-yl]acetamide\; SCHEMBL26017632 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)Cn4cc(-c5cccc(O)c5)nn4)c3)c12 Stabilizer C34H28FIN8O5 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-RP8O0Z SCHEMBL26017639 N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]-2-[4-(3-fluorophenyl)triazol-1-yl]acetamide\; SCHEMBL26017639 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)Cn4cc(-c5cccc(F)c5)nn4)c3)c12 Stabilizer C34H27F2IN8O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-M28UEJ SCHEMBL26017644 2-[4-(3-aminophenyl)triazol-1-yl]-N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide\; SCHEMBL26017644 Cc1c(=O)n(C)c(Nc2ccc(I)cc2F)c2c(=O)n(C3CC3)c(=O)n(-c3cccc(NC(=O)Cn4cc(-c5cccc(N)c5)nn4)c3)c12 Stabilizer C34H29FIN9O4 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-19NTZZ SCHEMBL25363447 Ethyl 2-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]anilino]-2-oxoacetate\; SCHEMBL25363447 CCOC(=O)C(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1 Stabilizer C28H25FIN5O6 BRAF;MEK1 P15056/Q02750 . US-20230381180-A1 TPD-62XH68 WO2020263832-A1_JADA-10 . NCCOc1ccnc(-n2cc(-c3cn[nH]c3N)cn2)c1 Degrader C13H15N7O IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2020263832-A1 TPD-QNCLTC WO2020263832-A1_JADA-8 . N#CCc1cnn(-c2cc(OCCN)ccn2)c1 Degrader C12H13N5O IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2020263832-A1 TPD-RRT1AU WO2020263832-A1_JADA-IMID2 . Cc1[nH]c2c(C)cnn2c(=O)c1C1CCC(=O)NC1=O Degrader C13H14N4O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2020263832-A1 TPD-1IVPUD WO2020263832-A1_JADA-IMID3 . Cc1[nH]c2ccnn2c(=O)c1C1CCC(=O)NC1=O Degrader C12H12N4O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2020263832-A1 TPD-75IPEV WO2020263832-A1_JADA20 . CC(C)c1c(NCCNC(=O)c2ccccc2)[nH]c2c(C#N)cnn2c1=O Degrader C19H20N6O2 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2020263832-A1 TPD-2FJH67 CS-0527102 5-Chloro-6-isopropyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbaldehyde\; 5-Chloro-6-isopropyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbaldehyde; CS-0527102; 2573901-15-0 CC(C)c1c(Cl)[nH]c2c(C=O)cnn2c1=O Degrader C10H10ClN3O2 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2020263832-A1 TPD-HNRSGO SCHEMBL23119754 N-[3-(2,6-dioxopiperidin-3-yl)-1-benzofuran-5-yl]-2-(trifluoromethyl)pyridine-4-carboxamide\; SCHEMBL23119754 O=C1CCC(c2coc3ccc(NC(=O)c4ccnc(C(F)(F)F)c4)cc23)C(=O)N1 Degrader C20H14F3N3O4 WEE1 P30291 CRBN WO-2021047627-A1 TPD-FRBV0R N-[3-(2,6-dioxopiperidin-3-yl)-1-benzofuran-5-yl]-4-methylbenzamide SCHEMBL23119749 Cc1ccc(C(=O)Nc2ccc3occ(C4CCC(=O)NC4=O)c3c2)cc1 Degrader C21H18N2O4 WEE1 P30291 CRBN WO-2021047627-A1 TPD-L1RDIX 3-chloro-N-[3-(2,6-dioxopiperidin-3-yl)-1-benzofuran-5-yl]benzamide SCHEMBL23119720 O=C1CCC(c2coc3ccc(NC(=O)c4cccc(Cl)c4)cc23)C(=O)N1 Degrader C20H15ClN2O4 WEE1 P30291 CRBN WO-2021047627-A1 TPD-RMK4Q8 N-[3-(2,6-dioxopiperidin-3-yl)-1-benzofuran-5-yl]benzamide SCHEMBL23119753 O=C1CCC(c2coc3ccc(NC(=O)c4ccccc4)cc23)C(=O)N1 Degrader C20H16N2O4 WEE1 P30291 CRBN WO-2021047627-A1 TPD-3DPVPV N-[3-(2,6-dioxopiperidin-3-yl)-1-benzofuran-5-yl]butanamide SCHEMBL23119736 CCCC(=O)Nc1ccc2occ(C3CCC(=O)NC3=O)c2c1 Degrader C17H18N2O4 WEE1 P30291 CRBN WO-2021047627-A1 TPD-U1UP3P N-[3-(2,6-dioxopiperidin-3-yl)-1-benzofuran-5-yl]furan-2-carboxamide SCHEMBL23119850 O=C1CCC(c2coc3ccc(NC(=O)c4ccco4)cc23)C(=O)N1 Degrader C18H14N2O5 WEE1 P30291 CRBN WO-2021047627-A1 TPD-IH78IZ SCHEMBL23119697 N-[3-(2,6-dioxopiperidin-3-yl)-1-benzofuran-5-yl]cyclopropanecarboxamide\; SCHEMBL23119697 O=C1CCC(c2coc3ccc(NC(=O)C4CC4)cc23)C(=O)N1 Degrader C17H16N2O4 WEE1 P30291 CRBN WO-2021047627-A1 TPD-OUN0Z6 SCHEMBL23121163 1-(1-Benzofuran-3-yl)-1,3-diazinane-2,4-dione O=C1CCN(C2=COC3=CC=CC=C32)C(=O)N1 Degrader C12H10N2O3 IKZF1 Q13422 CRBN WO-2021053555-A1 TPD-XS5RPH compound I-10 1-[6-(1-Benzylpiperidin-4-yl)imidazo[1,2-a]pyridin-3-yl]-1,3-diazinane-2,4-dione; SCHEMBL23121144 O=C1CCN(/C2=C/N=C3/C=CC(C4CCN(CC5=CC=CC=C5)CC4)=CN32)C(=O)N1 Degrader C23H25N5O2 IKZF1 Q13422 CRBN WO-2021053555-A1 TPD-9BQ0UC SCHEMBL23121173 1-[6-[3-(Dimethylamino)prop-1-ynyl]-1-benzofuran-3-yl]-1,3-diazinane-2,4-dione CN(C)CC#CC1=CC=C2C(=C1)OC=C2N1CCC(=O)NC1=O Degrader C17H17N3O3 IKZF1 Q13422 CRBN WO-2021053555-A1 TPD-M6WNU5 SCHEMBL23121188 N-benzyl-3-(2,4-dioxo-1,3-diazinan-1-yl)-1-benzofuran-6-carboxamide O=C1CCN(/C2=C/OC3=C2C=CC(C(=O)NCC2=CC=CC=C2)=C3)C(=O)N1 Degrader C20H17N3O4 IKZF1 Q13422 CRBN WO-2021053555-A1 TPD-2U5754 compound I-13 1-(6-Methyl-1,2-benzoxazol-3-yl)-1,3-diazinane-2,4-dione; SCHEMBL23121229 CC1=CC=C2C(=C1)ON=C2N1CCC(=O)NC1=O Degrader C12H11N3O3 IKZF1 Q13422 CRBN WO-2021053555-A1 TPD-4WNL25 SCHEMBL23121160 1-(5-Chloro-1,2-benzisoxazol-3-yl)dihydro-2,4(1H,3H)-pyrimidinedione; SCHEMBL29592023; DB-389742; 1-(5-Chloro-1,2-benzisoxazol-3-yl)dihydro-2,4(1H,3H)-pyrimidinedione; 2631059-95-3 O=C1CCN(C2=NOC3=CC=C(Cl)C=C32)C(=O)N1 Degrader C11H8ClN3O3 IKZF1 Q13422 CRBN WO-2021053555-A1 TPD-9V04QY SCHEMBL23121153 1-[6-[2-(4-Methylphenyl)ethoxy]-1,2-benzoxazol-3-yl]-1,3-diazinane-2,4-dione CC1=CC=C(CCOC2=CC=C3C(=C2)ON=C3N2CCC(=O)NC2=O)C=C1 Degrader C20H19N3O4 IKZF1 Q13422 CRBN WO-2021053555-A1 TPD-FYCDKQ SCHEMBL23121307 1-[6-(1-Benzylpiperidin-4-yl)quinolin-3-yl]pyrimidine-2,4-dione O=C1C=CN(C2=CC3=C(/C=C\C(C4CCN(CC5=CC=CC=C5)CC4)=C/3)N=C2)C(=O)N1 Degrader C25H24N4O2 IKZF1 Q13422 CRBN WO-2021053555-A1 TPD-HC9DU8 SCHEMBL23121215 1-[7-(1-benzyl-3,6-dihydro-2H-pyridin-4-yl)imidazo[1,2-a]pyridin-3-yl]pyrimidine-2,4-dione O=C1C=CN(/C2=C/N=C3/C=C(C4=CCN(CC5=CC=CC=C5)CC4)C=CN32)C(=O)N1 Degrader C23H21N5O2 IKZF1 Q13422 CRBN WO-2021053555-A1 TPD-Y3HBRH SCHEMBL25138140 3-(6-methyl-2,3-dihydro-1,4-oxathiine-5-carbonyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-thiazolidine-4-carboxamide\; SCHEMBL25138140 CC1=C(C(=O)N2CSCC2C(=O)/N=c2/[nH]cc(C)s2)SCCO1 Degrader C14H17N3O3S3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021074418-A1 TPD-Q7006C SCHEMBL23247407 3-(5-bromo-2-methylfuran-3-carbonyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-thiazolidine-4-carboxamide\; SCHEMBL23247407; SCHEMBL25138162 Cc1c[nH]/c(=N\C(=O)C2CSCN2C(=O)c2cc(Br)oc2C)s1 Degrader C14H14BrN3O3S2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021074418-A1 TPD-XFFE6A SCHEMBL23246817 3-(3,5-dimethylthiophene-2-carbonyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-thiazolidine-4-carboxamide\; SCHEMBL23246817; SCHEMBL25138173 Cc1cc(C)c(C(=O)N2CSCC2C(=O)/N=c2\[nH]cc(C)s2)s1 Degrader C15H17N3O2S3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021074418-A1 TPD-LTUKG9 SCHEMBL24101422 2-[2-[(6-fluoropyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide\; SCHEMBL24101422 Cc1cnc(NC(=O)Cc2csc(Nc3cccc(F)n3)n2)s1 Degrader C14H12FN5OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-PQRM07 SCHEMBL24101719 2-[2-[(6-chloropyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide\; SCHEMBL24101719 Cc1cnc(NC(=O)Cc2csc(Nc3cccc(Cl)n3)n2)s1 Degrader C14H12ClN5OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-H01ZDS SCHEMBL24101444 2-[2-[(6-bromopyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide\; SCHEMBL24101444 Cc1cnc(NC(=O)Cc2csc(Nc3cccc(Br)n3)n2)s1 Degrader C14H12BrN5OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-F6TQUM SCHEMBL24101766 2-[2-[(6-ethylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide\; SCHEMBL24101766 CCc1cccc(Nc2nc(CC(=O)Nc3ncc(C)s3)cs2)n1 Degrader C16H17N5OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-N3NSFW SCHEMBL24101428 2-[2-[(6-methoxypyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide\; SCHEMBL24101428 COc1cccc(Nc2nc(CC(=O)Nc3ncc(C)s3)cs2)n1 Degrader C15H15N5O2S2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-8EGPO8 SCHEMBL24101442 2-[2-[(6-aminopyridin-2-yl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide\; SCHEMBL24101442 Cc1cnc(NC(=O)Cc2csc(Nc3cccc(N)n3)n2)s1 Degrader C14H14N6OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-Q805SQ SCHEMBL24101426 N-(5-methyl-1,3-thiazol-2-yl)-2-[2-[(6-pyrazol-1-ylpyridin-2-yl)amino]-1,3-thiazol-4-yl]acetamide\; SCHEMBL24101426 Cc1cnc(NC(=O)Cc2csc(Nc3cccc(-n4cccn4)n3)n2)s1 Degrader C17H15N7OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-TEWQB4 SCHEMBL24101445 N-(5-methyl-1,3-thiazol-2-yl)-2-[2-[[6-(trifluoromethyl)pyridin-2-yl]amino]-1,3-thiazol-4-yl]acetamide\; SCHEMBL24101445 Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C(F)(F)F)n3)n2)s1 Degrader C15H12F3N5OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-JZZUWZ SCHEMBL24101625 N-(5-methyl-1,3-thiazol-2-yl)-2-[2-(pyridin-2-ylamino)-1,3-thiazol-4-yl]acetamide\; SCHEMBL24101625 Cc1cnc(NC(=O)Cc2csc(Nc3ccccn3)n2)s1 Degrader C14H13N5OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-QCCGIP 2-(2-amino-1,3-thiazol-4-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide SCHEMBL24101702; AKOS012092191 Cc1cnc(NC(=O)Cc2csc(N)n2)s1 Degrader C9H10N4OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-ZL3YEE SCHEMBL24101706 N-[4-(furan-2-yl)-1,3-thiazol-2-yl]-2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]acetamide\; SCHEMBL24101706 Cc1cccc(Nc2nc(CC(=O)Nc3nc(-c4ccco4)cs3)cs2)n1 Degrader C18H15N5O2S2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-D3KXVM WO2021249517-A1_glue01-013 . Nc1nc(CC(=O)Nc2ncc(-c3ccco3)s2)cs1 Degrader C12H10N4O2S2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-K9REUY SCHEMBL24101690 6-bromo-N-[4-[2-[(5-methyl-1,3-thiazol-2-yl)amino]-2-oxoethyl]-1,3-thiazol-2-yl]pyridine-2-carboxamide\; SCHEMBL24101690 Cc1cnc(NC(=O)Cc2csc(NC(=O)c3cccc(Br)n3)n2)s1 Degrader C15H12BrN5O2S2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-I9J3LU WO2021249517-A1_glue02-32 . CC1=N[NH2+]C(NC(=O)C2CN(c3cc(-n4cccn4)ncn3)C2)=C1 Degrader C15H17N8O+ CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-LXK3SK HQ005 2-(2-{[6-(hydroxymethyl)pyridin-2-yl]amino}-1,3-thiazol-4-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide\; HQ005; 2750644-31-4; 2-(2-{[6-(hydroxymethyl)pyridin-2-yl]amino}-1,3-thiazol-4-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide; CHEMBL5203698; SCHEMBL24101725; DA-64271; HY-148523; CS-0633992; EN300-37447426 Cc1cnc(NC(=O)Cc2csc(Nc3cccc(CO)n3)n2)s1 Degrader C15H15N5O2S2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-BGGEOC SCHEMBL24101608 1-(6-pyrazol-1-ylpyrimidin-4-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]azetidine-3-carboxamide\; SCHEMBL24101608 O=C(Nc1ncc(C(F)(F)F)s1)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C15H12F3N7OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-UOW4MH SCHEMBL24101614 N-(5-cyano-1,3-thiazol-2-yl)-1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidine-3-carboxamide\; SCHEMBL24101614 N#Cc1cnc(NC(=O)C2CN(c3cc(-n4cccn4)ncn3)C2)s1 Degrader C15H12N8OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-AF01N5 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)azetidine-3-carboxylic acid 2034156-76-6; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)azetidine-3-carboxylic acid; 1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidine-3-carboxylic acid; 1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxylic acid; SCHEMBL24101616; AKOS026679541; F1967-2609 O=C(O)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C11H11N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-RA7VYY F6495-5306 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(2-methylcyclohexyl)azetidine-3-carboxamide\; 2034360-38-6; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(2-methylcyclohexyl)azetidine-3-carboxamide; N-(2-methylcyclohexyl)-1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; SCHEMBL24101609; AKOS026691623; F6495-5306; N-(2-methylcyclohexyl)-1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidine-3-carboxamide CC1CCCCC1NC(=O)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C18H24N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-3EFS4J F6495-5321 (1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)(morpholino)methanone\; 2034280-48-1; (1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)(morpholino)methanone; 4-{1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carbonyl}morpholine; SCHEMBL24101620; AKOS026691626; F6495-5321; morpholin-4-yl-[1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidin-3-yl]methanone O=C(C1CN(c2cc(-n3cccn3)ncn2)C1)N1CCOCC1 Degrader C15H18N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-H2B75G F6495-5374 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(pyridin-4-yl)azetidine-3-carboxamide\; 2034581-04-7; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(pyridin-4-yl)azetidine-3-carboxamide; 1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]-N-(pyridin-4-yl)azetidine-3-carboxamide; AKOS026691636; F6495-5374; 1-(6-pyrazol-1-ylpyrimidin-4-yl)-N-pyridin-4-ylazetidine-3-carboxamide O=C(Nc1ccncc1)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C16H15N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-1F3HW0 SMSSF-0606901 1-(3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-N-(thiazol-2-yl)azetidine-3-carboxamide\; 1448125-88-9; F6351-0410; 1-(3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-N-(thiazol-2-yl)azetidine-3-carboxamide; 1-{3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}-N-(1,3-thiazol-2-yl)azetidine-3-carboxamide; SMSSF-0606901; AKOS024549164; 1-(3-ethyltriazolo[4,5-d]pyrimidin-7-yl)-N-(1,3-thiazol-2-yl)azetidine-3-carboxamide; N-(1,3-thiazol-2-yl)-1-(3-ethyl-1,2,3,4,6-pentaaza-3H-inden-7-yl)-3-azetidinecarboxamide CCn1nnc2c(N3CC(C(=O)Nc4nccs4)C3)ncnc21 Degrader C13H14N8OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-IK9IIB F6495-4519 1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(5-methylthiazol-2-yl)azetidine-3-carboxamide\; 2034366-50-0; 1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(5-methylthiazol-2-yl)azetidine-3-carboxamide; 1-[6-(1H-imidazol-1-yl)pyrimidin-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)azetidine-3-carboxamide; SCHEMBL24101611; AKOS032458536; F6495-4519; 1-(6-imidazol-1-ylpyrimidin-4-yl)-N-(5-methyl-1,3-thiazol-2-yl)azetidine-3-carboxamide Cc1cnc(NC(=O)C2CN(c3cc(-n4ccnc4)ncn3)C2)s1 Degrader C15H15N7OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-KCTSGF F6495-5395 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(3-chloro-4-fluorophenyl)azetidine-3-carboxamide\; 2034231-39-3; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(3-chloro-4-fluorophenyl)azetidine-3-carboxamide; N-(3-chloro-4-fluorophenyl)-1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidine-3-carboxamide; N-(3-chloro-4-fluorophenyl)-1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; SCHEMBL24102077; AKOS026691640; F6495-5395 O=C(Nc1ccc(F)c(Cl)c1)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C17H14ClFN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-TQO03Q F6495-5561 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(pyrazin-2-yl)azetidine-3-carboxamide\; 2034581-56-9; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(pyrazin-2-yl)azetidine-3-carboxamide; N-(pyrazin-2-yl)-1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; SCHEMBL24102038; AKOS026701758; F6495-5561; N-pyrazin-2-yl-1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidine-3-carboxamide O=C(Nc1cnccn1)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C15H14N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-2914XA F6495-5470 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-cyclopropylazetidine-3-carboxamide\; 2034360-78-4; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-cyclopropylazetidine-3-carboxamide; N-cyclopropyl-1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidine-3-carboxamide; N-cyclopropyl-1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; SCHEMBL24102074; AKOS026701754; F6495-5470 O=C(NC1CC1)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C14H16N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-4M9RYJ F6495-5555 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(2-(1H-pyrrol-1-yl)ethyl)azetidine-3-carboxamide\; 2034481-12-2; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(2-(1H-pyrrol-1-yl)ethyl)azetidine-3-carboxamide; 1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]-N-[2-(1H-pyrrol-1-yl)ethyl]azetidine-3-carboxamide; SCHEMBL24102076; AKOS026701756; F6495-5555; 1-(6-pyrazol-1-ylpyrimidin-4-yl)-N-(2-pyrrol-1-ylethyl)azetidine-3-carboxamide O=C(NCCn1cccc1)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C17H19N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-RSB02N F6495-5452 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-methyl-N-phenylazetidine-3-carboxamide\; F6495-5452; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-methyl-N-phenylazetidine-3-carboxamide CN(C(=O)C1CN(c2cc(-n3cccn3)ncn2)C1)c1ccccc1 Degrader C18H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-SEDQPF F6495-5487 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)azetidine-3-carboxamide\; 2034480-63-0; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)azetidine-3-carboxamide; N-(5-methyl-1,3,4-thiadiazol-2-yl)-1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; SCHEMBL24102083; AKOS026691655; F6495-5487; N-(5-methyl-1,3,4-thiadiazol-2-yl)-1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidine-3-carboxamide Cc1nnc(NC(=O)C2CN(c3cc(-n4cccn4)ncn3)C2)s1 Degrader C14H14N8OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-25GUHQ F6495-5493 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(4-(furan-2-yl)thiazol-2-yl)azetidine-3-carboxamide\; 2034281-31-5; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(4-(furan-2-yl)thiazol-2-yl)azetidine-3-carboxamide; N-[4-(furan-2-yl)-1,3-thiazol-2-yl]-1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; SCHEMBL24102080; AKOS026691658; F6495-5493; N-[4-(furan-2-yl)-1,3-thiazol-2-yl]-1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidine-3-carboxamide O=C(Nc1nc(-c2ccco2)cs1)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C18H15N7O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-DDIZSV F6495-4529 ethyl 2-(1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)azetidine-3-carboxamido)-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylate\; 2034230-32-3; ethyl 2-(1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)azetidine-3-carboxamido)-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylate; ethyl 2-[[1-(6-imidazol-1-ylpyrimidin-4-yl)azetidine-3-carbonyl]amino]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxylate; ethyl 2-{1-[6-(1H-imidazol-1-yl)pyrimidin-4-yl]azetidine-3-amido}-4H,5H,6H-cyclopenta[d][1,3]thiazole-4-carboxylate; SCHEMBL24102084; AKOS026691622; F6495-4529 CCOC(=O)C1CCc2sc(NC(=O)C3CN(c4cc(-n5ccnc5)ncn4)C3)nc21 Degrader C20H21N7O3S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-9CHE9Z F6495-4511 1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(2-bromophenyl)azetidine-3-carboxamide\; 2034583-03-2; 1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(2-bromophenyl)azetidine-3-carboxamide; N-(2-bromophenyl)-1-(6-imidazol-1-ylpyrimidin-4-yl)azetidine-3-carboxamide; N-(2-bromophenyl)-1-[6-(1H-imidazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; AKOS026691619; F6495-4511 O=C(Nc1ccccc1Br)C1CN(c2cc(-n3ccnc3)ncn2)C1 Degrader C17H15BrN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-115CK4 F6495-4513 1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(1H-1,2,4-triazol-5-yl)azetidine-3-carboxamide\; 2034478-07-2; 1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(1H-1,2,4-triazol-5-yl)azetidine-3-carboxamide; 1-[6-(1H-imidazol-1-yl)pyrimidin-4-yl]-N-(1H-1,2,4-triazol-5-yl)azetidine-3-carboxamide; AKOS032458534; F6495-4513; 1-(6-imidazol-1-ylpyrimidin-4-yl)-N-(1H-1,2,4-triazol-5-yl)azetidine-3-carboxamide O=C(Nc1nnc[nH]1)C1CN(c2cc(-n3ccnc3)ncn2)C1 Degrader C13H13N9O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-FWX60B F6495-5734 ethyl 2-(2-(1-(6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)azetidine-3-carboxamido)thiazol-4-yl)acetate\; 2034361-55-0; ethyl 2-(2-(1-(6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)azetidine-3-carboxamido)thiazol-4-yl)acetate; ethyl 2-[2-[[1-[6-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carbonyl]amino]-1,3-thiazol-4-yl]acetate; ethyl 2-(2-{1-[6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-amido}-1,3-thiazol-4-yl)acetate; SCHEMBL24102087; AKOS026701763; F6495-5734 CCOC(=O)Cc1csc(NC(=O)C2CN(c3cc(-n4nc(C)cc4C)ncn3)C2)n1 Degrader C20H23N7O3S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-X5MENE F6495-5377 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(thiazol-2-yl)azetidine-3-carboxamide\; SCHEMBL24102073; F6495-5377; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(thiazol-2-yl)azetidine-3-carboxamide O=C(Nc1nccs1)C1CN(c2cc(-n3cccn3)ncn2)C1 Degrader C14H13N7OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-J39BAQ F6495-5581 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(5-methylthiazol-2-yl)azetidine-3-carboxamide\; 2034581-68-3; 1-(6-(1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(5-methylthiazol-2-yl)azetidine-3-carboxamide; N-(5-methyl-1,3-thiazol-2-yl)-1-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; SCHEMBL24101435; AKOS026691682; F6495-5581; N-(5-methyl-1,3-thiazol-2-yl)-1-(6-pyrazol-1-ylpyrimidin-4-yl)azetidine-3-carboxamide Cc1cnc(NC(=O)C2CN(c3cc(-n4cccn4)ncn3)C2)s1 Degrader C15H15N7OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-IT4B9U F6495-4316 1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(4-methylthiazol-2-yl)azetidine-3-carboxamide\; 2034229-11-1; 1-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(4-methylthiazol-2-yl)azetidine-3-carboxamide; 1-[6-(1H-imidazol-1-yl)pyrimidin-4-yl]-N-(4-methyl-1,3-thiazol-2-yl)azetidine-3-carboxamide; SCHEMBL24101450; AKOS032458507; F6495-4316; 1-(6-imidazol-1-ylpyrimidin-4-yl)-N-(4-methyl-1,3-thiazol-2-yl)azetidine-3-carboxamide Cc1csc(NC(=O)C2CN(c3cc(-n4ccnc4)ncn3)C2)n1 Degrader C15H15N7OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-YSCJ7U F6495-5858 1-(6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(4,5-dimethylthiazol-2-yl)azetidine-3-carboxamide\; 2034473-89-5; 1-(6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(4,5-dimethylthiazol-2-yl)azetidine-3-carboxamide; N-(4,5-dimethyl-1,3-thiazol-2-yl)-1-[6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; SCHEMBL24102075; AKOS026691723; F6495-5858; 1-[6-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]-N-(4,5-dimethyl-1,3-thiazol-2-yl)azetidine-3-carboxamide Cc1cc(C)n(-c2cc(N3CC(C(=O)Nc4nc(C)c(C)s4)C3)ncn2)n1 Degrader C18H21N7OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-JOFWYA F6495-5910 1-(6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(4-(pyridin-2-yl)thiazol-2-yl)azetidine-3-carboxamide\; 2034232-93-2; 1-(6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)-N-(4-(pyridin-2-yl)thiazol-2-yl)azetidine-3-carboxamide; 1-[6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl]-N-[4-(pyridin-2-yl)-1,3-thiazol-2-yl]azetidine-3-carboxamide; SCHEMBL24102078; AKOS026691730; F6495-5910; 1-[6-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)azetidine-3-carboxamide Cc1cc(C)n(-c2cc(N3CC(C(=O)Nc4nc(-c5ccccn5)cs4)C3)ncn2)n1 Degrader C21H20N8OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-NYX5B5 F6495-5023 1-(6-(1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)-N-(thiazol-2-yl)azetidine-3-carboxamide\; 2034478-55-0; 1-(6-(1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)-N-(thiazol-2-yl)azetidine-3-carboxamide; N-(1,3-thiazol-2-yl)-1-[6-(1H-1,2,4-triazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide; SCHEMBL24102128; AKOS026701702; F6495-5023; N-(1,3-thiazol-2-yl)-1-[6-(1,2,4-triazol-1-yl)pyrimidin-4-yl]azetidine-3-carboxamide O=C(Nc1nccs1)C1CN(c2cc(-n3cncn3)ncn2)C1 Degrader C13H12N8OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-WI8THB F6495-4163 Ethyl 4-methyl-2-(1-(6-phenylpyrimidin-4-yl)azetidine-3-carboxamido)thiazole-5-carboxylate\; 2034258-23-4; ethyl 4-methyl-2-(1-(6-phenylpyrimidin-4-yl)azetidine-3-carboxamido)thiazole-5-carboxylate; ethyl 4-methyl-2-[1-(6-phenylpyrimidin-4-yl)azetidine-3-amido]-1,3-thiazole-5-carboxylate; SCHEMBL24102131; AKOS026701686; F6495-4163; ethyl 4-methyl-2-[[1-(6-phenylpyrimidin-4-yl)azetidine-3-carbonyl]amino]-1,3-thiazole-5-carboxylate CCOC(=O)c1sc(NC(=O)C2CN(c3cc(-c4ccccc4)ncn3)C2)nc1C Degrader C21H21N5O3S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2021249517-A1 TPD-UIADYD WO2022169755-A1_1 . COOCCNS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C17H17Cl2N3O6S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-4KE7PW SCHEMBL24762082 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-[[1-(3-phenylpropyl)piperidin-4-yl]methyl]benzene-1,4-disulfonamide\; SCHEMBL24762082 O=S(=O)(NCC1CCN(CCCc2ccccc2)CC1)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C29H32Cl2N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-WQ7TX3 WO2022169755-A1_100 . Cc1ccc(N[SH](OO)c2cccc(C#N)c2)c2[nH]cc(C(F)F)c12 Degrader C17H15F2N3O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-GIYPDQ SCHEMBL24762711 3-cyano-N-[3-(difluoromethyl)-4-methyl-1H-indol-7-yl]-5-fluorobenzenesulfonamide\; SCHEMBL24762711 Cc1ccc(NS(=O)(=O)c2cc(F)cc(C#N)c2)c2[nH]cc(C(F)F)c12 Degrader C17H12F3N3O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-93RSCV N-(3-chloro-4-iodo-1H-indol-7-yl)-2-cyanobenzenesulfonamide SCHEMBL24762854 N#Cc1ccccc1S(=O)(=O)Nc1ccc(I)c2c(Cl)c[nH]c12 Degrader C15H9ClIN3O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-UN0VGI N-(3-chloro-5-methoxy-1H-indol-7-yl)-3-cyanobenzenesulfonamide SCHEMBL24762246 COc1cc(NS(=O)(=O)c2cccc(C#N)c2)c2[nH]cc(Cl)c2c1 Degrader C16H12ClN3O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-1HU023 3-cyano-N-(3,4-dichloro-5-methoxy-1H-indol-7-yl)benzenesulfonamide SCHEMBL24762097 COc1cc(NS(=O)(=O)c2cccc(C#N)c2)c2[nH]cc(Cl)c2c1Cl Degrader C16H11Cl2N3O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-5WF2WD SCHEMBL24762081 1-N-(7-bicyclo[4.2.0]octa-1,3,5-trienylmethyl)-4-N-(3,4-dichloro-1H-indol-7-yl)benzene-1,4-disulfonamide\; SCHEMBL24762081 O=S(=O)(NCC1Cc2ccccc21)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C23H19Cl2N3O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-SBPSOD SCHEMBL24762647 1-N-(3,4-dichloro-1H-indol-7-yl)-2-fluoro-4-N-(6-oxopiperidin-3-yl)benzene-1,4-disulfonamide\; SCHEMBL24762647 O=C1CCC(NS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)CN1 Degrader C19H17Cl2FN4O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-E0JR4B SCHEMBL24762091 N-(3,4-dichloro-1H-indol-7-yl)-3-piperidin-1-ylsulfonylbenzenesulfonamide\; SCHEMBL24762091 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(S(=O)(=O)N2CCCCC2)c1 Degrader C19H19Cl2N3O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-UZJ4JJ SCHEMBL24762094 N-(3,4-dichloro-1H-indol-7-yl)-4-methyl-3-piperidin-1-ylsulfonylbenzenesulfonamide\; SCHEMBL24762094 Cc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1S(=O)(=O)N1CCCCC1 Degrader C20H21Cl2N3O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-9RYF2E WO2022169755-A1_108 . O=S(=O)(c1ccc([SH](Nc2cccc3c(Cl)c[nH]c23)OO)cc1)N1CCNCC1 Degrader C18H21ClN4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-RH0JDE SCHEMBL24762092 N-(3,4-dichloro-1H-indol-7-yl)-4-(3-methylpiperazin-1-yl)sulfonylbenzenesulfonamide\; SCHEMBL24762092 CC1CN(S(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)CCN1 Degrader C19H20Cl2N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-C1GRQ1 SCHEMBL24762080 3-[[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]sulfonylamino]-N,N-dimethyl-3-phenylpropanamide\; SCHEMBL24762080 CN(C)C(=O)CC(NS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1)c1ccccc1 Degrader C25H24Cl2N4O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-ROVNYT SCHEMBL24761995 N-(3,4-dichloro-1H-indol-7-yl)-4-(3-propylpiperazin-1-yl)sulfonylbenzenesulfonamide\; SCHEMBL24761995 CCCC1CN(S(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)CCN1 Degrader C21H24Cl2N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-M0OOSW SCHEMBL24762135 N-[[5-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-methoxyphenyl]methyl]propanamide\; SCHEMBL24762135 CCC(=O)NCc1cc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)ccc1OC Degrader C19H19Cl2N3O4S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-S97NI5 N-[2-[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]ethyl]acetamide SCHEMBL24762133 CC(=O)NCCc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C18H17Cl2N3O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-NVO5PG SCHEMBL24762589 tert-butyl N-[[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]methyl]carbamate\; SCHEMBL24762589 CC(C)(C)OC(=O)NCc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C20H21Cl2N3O4S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-LIVD7Y SCHEMBL24762587 tert-butyl N-[2-[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]ethyl]carbamate\; SCHEMBL24762587 CC(C)(C)OC(=O)NCCc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C21H23Cl2N3O4S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-1INYTQ SCHEMBL24762586 N-(3,4-dichloro-1H-indol-7-yl)-3-(1,2,4-triazol-4-ylmethyl)benzenesulfonamide\; SCHEMBL24762586 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(Cn2cnnc2)c1 Degrader C17H13Cl2N5O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-JDKR1Q 4-cyclohexyl-N-(3,4-dichloro-1H-indol-7-yl)benzenesulfonamide SCHEMBL24762796 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(C2CCCCC2)cc1 Degrader C20H20Cl2N2O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-6PPJZV 3-chloro-N-(3,4-dichloro-1H-indol-7-yl)-5-phenylbenzenesulfonamide SCHEMBL24762797 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cc(Cl)cc(-c2ccccc2)c1 Degrader C20H13Cl3N2O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-Z2UWH8 N-(3,4-dichloro-1H-indol-7-yl)-4-thiophen-2-ylbenzenesulfonamide SCHEMBL24762804 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(-c2cccs2)cc1 Degrader C18H12Cl2N2O2S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-688O2M SCHEMBL24762791 N-(3,4-dichloro-1H-indol-7-yl)-3-(3-methylthiophen-2-yl)benzenesulfonamide\; SCHEMBL24762791 Cc1ccsc1-c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1 Degrader C19H14Cl2N2O2S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-ASSQ11 SCHEMBL24762699 4-[[[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]sulfonylamino]methyl]-N,N-diethylbenzamide\; SCHEMBL24762699 CCN(CC)C(=O)c1ccc(CNS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)cc1 Degrader C26H26Cl2N4O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-I82DLS SCHEMBL24762792 N-(3,4-dichloro-1H-indol-7-yl)-3-(2-methylpyrazol-3-yl)benzenesulfonamide\; SCHEMBL24762792 Cn1nccc1-c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1 Degrader C18H14Cl2N4O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-038AZ2 SCHEMBL24762798 N-(3,4-dichloro-1H-indol-7-yl)-2-methyl-5-(2-methyl-1,3-thiazol-4-yl)benzenesulfonamide\; SCHEMBL24762798 Cc1nc(-c2ccc(C)c(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2)cs1 Degrader C19H15Cl2N3O2S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-QNW2E4 SCHEMBL24762802 N-(3,4-dichloro-1H-indol-7-yl)-3-(1,3,4-oxadiazol-2-yl)benzenesulfonamide\; SCHEMBL24762802 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(-c2nnco2)c1 Degrader C16H10Cl2N4O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-523ZK0 SCHEMBL24762577 N-(3,4-dichloro-1H-indol-7-yl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)benzenesulfonamide\; SCHEMBL24762577 Cc1nc(-c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2)no1 Degrader C17H12Cl2N4O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-IFYYOM SCHEMBL24762578 N-(3,4-dichloro-1H-indol-7-yl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzenesulfonamide\; SCHEMBL24762578 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(-c2noc(C(F)(F)F)n2)cc1 Degrader C17H9Cl2F3N4O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-QO1498 SCHEMBL24762727 N-(3,4-dichloro-1H-indol-7-yl)-4-(4,5-dichloro-6-oxopyridazin-1-yl)benzenesulfonamide\; SCHEMBL24762727 O=c1c(Cl)c(Cl)cnn1-c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C18H10Cl4N4O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-48SQWS SCHEMBL24762576 N-(3,4-dichloro-1H-indol-7-yl)-3-(1-methyltetrazol-5-yl)benzenesulfonamide\; SCHEMBL24762576 Cn1nnnc1-c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1 Degrader C16H12Cl2N6O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-4BGH4M N-(3,4-dichloro-1H-indol-7-yl)-3-(tetrazol-1-yl)benzenesulfonamide SCHEMBL24762142 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(-n2cnnn2)c1 Degrader C15H10Cl2N6O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-Z23ND8 SCHEMBL24761989 N-(3,4-dichloro-1H-indol-7-yl)-4-(propylsulfonylamino)benzenesulfonamide\; SCHEMBL24761989 CCCS(=O)(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C17H17Cl2N3O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-5I3O6K SCHEMBL24761992 N-(3,4-dichloro-1H-indol-7-yl)-3-fluoro-4-(propylsulfonylamino)benzenesulfonamide\; SCHEMBL24761992 CCCS(=O)(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1F Degrader C17H16Cl2FN3O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-9IN3V8 N-[5-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-methoxyphenyl]acetamide SCHEMBL24761993 COc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1NC(C)=O Degrader C17H15Cl2N3O4S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-UZPA73 SCHEMBL24762704 N-[3-[[[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]sulfonylamino]methyl]phenyl]-2-methylpropanamide\; SCHEMBL24762704 CC(C)C(=O)Nc1cccc(CNS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)c1 Degrader C25H24Cl2N4O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-ACOQHC SCHEMBL24761973 N-[2,6-dichloro-4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]acetamide\; SCHEMBL24761973 CC(=O)Nc1c(Cl)cc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1Cl Degrader C16H11Cl4N3O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-0P4X99 SCHEMBL24761976 2-amino-N-[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]-N-propylacetamide\; SCHEMBL24761976 CCCN(C(=O)CN)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C19H20Cl2N4O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-BX2F2Q SCHEMBL24761974 N-[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]-N-propyl-2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetamide\; SCHEMBL24761974 C#CCOCCOCCOCC(=O)N(CCC)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C26H29Cl2N3O6S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-LPDBPR 4-acetyl-N-(3,4-dichloro-1H-indol-7-yl)benzenesulfonamide SCHEMBL24761975 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C16H12Cl2N2O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-YLIAZR SCHEMBL24762563 N-(3,4-dichloro-1H-indol-7-yl)-4-(2,2,2-trifluoroacetyl)benzenesulfonamide\; SCHEMBL24762563 O=C(c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1)C(F)(F)F Degrader C16H9Cl2F3N2O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-5HJ40B WO2022169755-A1_135 . Cc1c[nH]c2c(NS(=O)(=O)c3cccc(C(=O)c4ccccc4)c3)ccc(Cl)c12 Degrader C22H17ClN2O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-3NQ54G SCHEMBL24762562 N-(3,4-dichloro-1H-indol-7-yl)-4-fluoro-3-methylsulfonylbenzenesulfonamide\; SCHEMBL24762562 CS(=O)(=O)c1cc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)ccc1F Degrader C15H11Cl2FN2O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-D3BLSB N-(3,4-dichloro-1H-indol-7-yl)-4-propylsulfonylbenzenesulfonamide SCHEMBL24762560 CCCS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C17H16Cl2N2O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-673YRW SCHEMBL24762558 N-(3,4-dichloro-1H-indol-7-yl)-3-(methylsulfonylmethyl)benzenesulfonamide\; SCHEMBL24762558 CS(=O)(=O)Cc1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1 Degrader C16H14Cl2N2O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-YXJFPN SCHEMBL24762148 methyl N-[2-chloro-4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]carbamate\; SCHEMBL24762148 COC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1Cl Degrader C16H12Cl3N3O4S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-Z1CXQ7 SCHEMBL24762700 1-N-(3,4-dichloro-1H-indol-7-yl)-4-N-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)propyl]benzene-1,4-disulfonamide\; SCHEMBL24762700; SCHEMBL24763410 CCC(NS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1)c1ccc2c(c1)OCCO2 Degrader C25H23Cl2N3O6S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-NKR8I5 3,5-dichloro-N-(3,4-dichloro-1H-indol-7-yl)benzenesulfonamide SCHEMBL24762150 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cc(Cl)cc(Cl)c1 Degrader C14H8Cl4N2O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-V63OKA SCHEMBL24762149 N-(3,4-dichloro-1H-indol-7-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide\; SCHEMBL24762149 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 Degrader C16H8Cl2F6N2O2S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-EJ8J4Q SCHEMBL24762145 3,5-dichloro-N-(3,4-dichloro-1H-indol-7-yl)-4-hydroxybenzenesulfonamide\; SCHEMBL24762145 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cc(Cl)c(O)c(Cl)c1 Degrader C14H8Cl4N2O3S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-VO1NKI WO2022169755-A1_143 . C#CCOCCOCCOc1cc(S(=O)(=O)Nc2ccc(C)c3c(Cl)c[nH]c23)cc(S(=O)(=O)N2CCNCC2)c1 Degrader C26H31ClN4O7S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-12HVBB SCHEMBL24762122 N-(3,4-dichloro-1H-indol-7-yl)-3-piperazin-1-ylsulfonyl-4-[2-(2-prop-2-ynoxyethoxy)ethoxy]benzenesulfonamide\; SCHEMBL24762122 C#CCOCCOCCOc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1S(=O)(=O)N1CCNCC1 Degrader C25H28Cl2N4O7S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-4CSZJO WO2022169755-A1_145 . O=S(=O)(c1ccc([SH](Nc2cccc3cc[nH]c23)OO)cc1)N1CCNCC1 Degrader C18H22N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-0VI68X SCHEMBL24762100 N-(1H-indol-7-yl)-4-piperazin-1-ylsulfonyl-3-[2-(2-prop-2-ynoxyethoxy)ethoxy]benzenesulfonamide\; SCHEMBL24762100 C#CCOCCOCCOc1cc(S(=O)(=O)Nc2cccc3cc[nH]c23)ccc1S(=O)(=O)N1CCNCC1 Degrader C25H30N4O7S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-ED2QOI SCHEMBL24762098 N-(3-chloro-4-cyclopropyl-1H-indol-7-yl)-4-piperazin-1-ylsulfonylbenzenesulfonamide\; SCHEMBL24762098 O=S(=O)(Nc1ccc(C2CC2)c2c(Cl)c[nH]c12)c1ccc(S(=O)(=O)N2CCNCC2)cc1 Degrader C21H23ClN4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-XBIFS9 SCHEMBL24762103 N-[4-(1H-indol-7-ylsulfamoyl)phenyl]-N-propyl-2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetamide\; SCHEMBL24762103 C#CCOCCOCCOCC(=O)N(CCC)c1ccc(S(=O)(=O)Nc2cccc3cc[nH]c23)cc1 Degrader C26H31N3O6S RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-GI0PYH SCHEMBL24762702 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-[(1,5-dimethylpyrazol-3-yl)methyl]benzene-1,4-disulfonamide\; SCHEMBL24762702 Cc1cc(CNS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)nn1C Degrader C20H19Cl2N5O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-PAI5FU SCHEMBL24763388 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-[(4-methylpyridin-2-yl)methyl]benzene-1,4-disulfonamide\; SCHEMBL24763388 Cc1ccnc(CNS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)c1 Degrader C21H18Cl2N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-KXIRBX SCHEMBL24762705 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-[[6-(3-methoxyphenoxy)pyridin-3-yl]methyl]benzene-1,4-disulfonamide\; SCHEMBL24762705 COc1cccc(Oc2ccc(CNS(=O)(=O)c3ccc(S(=O)(=O)Nc4ccc(Cl)c5c(Cl)c[nH]c45)cc3)cn2)c1 Degrader C27H22Cl2N4O6S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-9900ZJ SCHEMBL24762547 4-N-[cyclopropyl-(4-methylpyridin-2-yl)methyl]-1-N-(3,4-dichloro-1H-indol-7-yl)benzene-1,4-disulfonamide\; SCHEMBL24762547 Cc1ccnc(C(NS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)C2CC2)c1 Degrader C24H22Cl2N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-9JJRXD SCHEMBL24762548 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-[(5-methylpyrazin-2-yl)methyl]benzene-1,4-disulfonamide\; SCHEMBL24762548 Cc1cnc(CNS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)cn1 Degrader C20H17Cl2N5O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-5LS92T WO2022169755-A1_2 . COCCNS(=O)(=O)c1ccc([SH](Nc2ccc(Cl)c3c(Cl)c[nH]c23)OO)cc1 Degrader C17H19Cl2N3O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-20LEUN SCHEMBL24762549 1-N-(3,4-dichloro-1H-indol-7-yl)-4-N-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-4-N-methylbenzene-1,4-disulfonamide\; SCHEMBL24762549 CCc1nc(CN(C)S(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)no1 Degrader C20H19Cl2N5O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-O0YG5R SCHEMBL24762877 4-N-[1-(1H-benzimidazol-2-yl)-3-methylbutyl]-1-N-(3,4-dichloro-1H-indol-7-yl)benzene-1,4-disulfonamide\; SCHEMBL24762877 CC(C)CC(NS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1)c1nc2ccccc2[nH]1 Degrader C26H25Cl2N5O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-48KCJX SCHEMBL24762708 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-[2-(1-methylazetidin-3-yl)ethyl]benzene-1,4-disulfonamide\; SCHEMBL24762708 CN1CC(CCNS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)C1 Degrader C20H22Cl2N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-JQHU5O SCHEMBL24762707 4-[2-[[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenyl]sulfonylamino]ethyl]-N,N-dimethylbenzamide\; SCHEMBL24762707 CN(C)C(=O)c1ccc(CCNS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)cc1 Degrader C25H24Cl2N4O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-VENRS2 SCHEMBL24762710 1-N-[3-(4-chlorophenyl)propyl]-4-N-(3,4-dichloro-1H-indol-7-yl)benzene-1,4-disulfonamide\; SCHEMBL24762710 O=S(=O)(NCCCc1ccc(Cl)cc1)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C23H20Cl3N3O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-3SZYI2 SCHEMBL24762067 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-[2-(5-methylfuran-2-yl)ethyl]benzene-1,4-disulfonamide\; SCHEMBL24762067 Cc1ccc(CCNS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)o1 Degrader C21H19Cl2N3O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-IEXUR2 SCHEMBL24762070 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-(2-pyridin-2-ylethyl)benzene-1,4-disulfonamide\; SCHEMBL24762070 O=S(=O)(NCCc1ccccn1)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C21H18Cl2N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-AWZIUJ SCHEMBL24762069 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-(4-oxo-4-pyrrolidin-1-ylbutyl)benzene-1,4-disulfonamide\; SCHEMBL24762069 O=C(CCCNS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1)N1CCCC1 Degrader C22H24Cl2N4O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-Q13RM6 WO2022169755-A1_28 . Cc1c[nH]c2c(N[SH](OO)c3ccc(S(=O)(=O)NC4CCOCC4)cc3)ccc(Cl)c12 Degrader C20H24ClN3O5S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-G7RUFW SCHEMBL24762175 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-piperidin-4-ylbenzene-1,4-disulfonamide\; SCHEMBL24762175 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(S(=O)(=O)NC2CCNCC2)cc1 Degrader C19H20Cl2N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-BJ6EXS SCHEMBL24762538 4-N-(3,4-dichloro-1H-indol-7-yl)-1-N-(2-ethylsulfonylethyl)benzene-1,4-disulfonamide\; SCHEMBL24762538 CCS(=O)(=O)CCNS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C18H19Cl2N3O6S3 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-7H9281 SCHEMBL24762023 1-N-(3,4-dichloro-1H-indol-7-yl)-4-N-piperidin-4-yl-4-N-propylbenzene-1,4-disulfonamide\; SCHEMBL24762023 CCCN(C1CCNCC1)S(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C22H26Cl2N4O4S2 RBM39 Q14498 DCAF15 WO-2022169755-A1 TPD-Y131Z2 WO2022173805-A1_1 N-(3,4-dichloro-1H-indol-7-yl)-2-fluoro-3-(4-methylsulfonylcyclohexyl)oxybenzenesulfonamide CS(=O)(=O)[C@H]1CC[C@H](Oc2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)CC1 Degrader C21H21Cl2FN2O5S2 RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-ZCRP9Y WO2022173805-A1_100 N-(3,4-dichloro-1H-indol-7-yl)-3-[3-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]propoxy]benzenesulfonamide CCc1cnc(N2CCC(CCCOc3cccc(S(=O)(=O)Nc4ccc(Cl)c5c(Cl)c[nH]c45)c3)CC2)nc1 Degrader C28H31Cl2N5O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-4O7IWW WO2022173805-A1_101 N-(3,4-dichloro-1H-indol-7-yl)-4-[3-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]propoxy]benzenesulfonamide CCc1cnc(N2CCC(CCCOc3ccc(S(=O)(=O)Nc4ccc(Cl)c5c(Cl)c[nH]c45)cc3)CC2)nc1 Degrader C28H31Cl2N5O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-9NX6LS WO2022173805-A1_104 . CN1CCN(CCCOc2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2)CC1 Degrader C22H26Cl2N4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-FIZX27 WO2022173805-A1_105 . CN1CCN(CCCOc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)CC1 Degrader C22H26Cl2N4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-NGH0ES WO2022173805-A1_108 . O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(OCCCN2CC3(COC3)C2)c1 Degrader C22H23Cl2N3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-WBS7J7 WO2022173805-A1_109 . O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(OCCCN2CC3(COC3)C2)cc1 Degrader C22H23Cl2N3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-1BJ31G WO2022173805-A1_110 4-[3-(1,3-benzodioxol-5-yl)propoxy]-N-(3,4-dichloro-1H-indol-7-yl)benzenesulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(OCCCc2ccc3c(c2)OCO3)cc1 Degrader C24H20Cl2N2O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-IOE4P9 WO2022173805-A1_111 . O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(OCCCc2ccc3c(c2)OCO3)c1 Degrader C24H20Cl2N2O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-1AWXXH WO2022173805-A1_112 N-(3,4-dichloro-1H-indol-7-yl)-3-[3-(2-oxo-1,3-benzoxazol-3-yl)propoxy]benzenesulfonamide O=c1oc2ccccc2n1CCCOc1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1 Degrader C24H19Cl2N3O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-QJS15I WO2022173805-A1_113 N-(3,4-dichloro-1H-indol-7-yl)-4-[3-(2-oxo-1,3-benzoxazol-3-yl)propoxy]benzenesulfonamide O=c1oc2ccccc2n1CCCOc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C24H19Cl2N3O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-K9QOCR WO2022173805-A1_114 . O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(OCCCN2CCCc3ccccc32)c1 Degrader C26H25Cl2N3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-DIIVRV WO2022173805-A1_115 N-(3,4-dichloro-1H-indol-7-yl)-4-[3-(3,4-dihydro-2H-quinolin-1-yl)propoxy]-2-fluorobenzenesulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(OCCCN2CCCc3ccccc32)cc1F Degrader C26H24Cl2FN3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-JS5GP5 WO2022173805-A1_116 N-(3,4-dichloro-1H-indol-7-yl)-2-fluoro-3-(3-pyrazol-1-ylpropoxy)benzenesulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(OCCCn2cccn2)c1F Degrader C20H17Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-BX0BER WO2022173805-A1_117 N-(3,4-dichloro-1H-indol-7-yl)-2-fluoro-4-(3-pyrazol-1-ylpropoxy)benzenesulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(OCCCn2cccn2)cc1F Degrader C20H17Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-T81KQC WO2022173805-A1_12 benzyl N-[(1R,3R)-3-[3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluorophenoxy]cyclohexyl]carbamate O=C(N[C@@H]1CCC[C@@H](Oc2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)C1)OCc1ccccc1 Degrader C28H26Cl2FN3O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-FVCXIY WO2022173805-A1_120 N-(3,4-dichloro-1H-indol-7-yl)-2-fluoro-3-[3-(3-methylimidazol-4-yl)propoxy]benzenesulfonamide Cn1cncc1CCCOc1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C21H19Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-C5LZQ0 WO2022173805-A1_121 N-(3,4-dichloro-1H-indol-7-yl)-2-fluoro-4-[3-(3-methylimidazol-4-yl)propoxy]benzenesulfonamide Cn1cncc1CCCOc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C21H19Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-HOIDP9 WO2022173805-A1_122 N-(3,4-dichloro-1H-indol-7-yl)-3-[3-(1-ethylpyrazol-4-yl)propoxy]-2-fluorobenzenesulfonamide CCn1cc(CCCOc2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)cn1 Degrader C22H21Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-ED9HVK WO2022173805-A1_123 N-(3,4-dichloro-1H-indol-7-yl)-4-[3-(1-ethylpyrazol-4-yl)propoxy]-2-fluorobenzenesulfonamide CCn1cc(CCCOc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)cn1 Degrader C22H21Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-IMVQXF WO2022173805-A1_124 methyl 2-[4-[3-[3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluorophenoxy]propyl]triazol-1-yl]acetate COC(=O)Cn1cc(CCCOc2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)nn1 Degrader C22H20Cl2FN5O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-SJ5WG9 WO2022173805-A1_128 N-(3,4-dichloro-1H-indol-7-yl)-2-fluoro-3-[3-(1-methylbenzimidazol-2-yl)propoxy]benzenesulfonamide Cn1c(CCCOc2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)nc2ccccc21 Degrader C25H21Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-N1UL8B WO2022173805-A1_129 N-(3,4-dichloro-1H-indol-7-yl)-2-fluoro-4-[3-(1-methylbenzimidazol-2-yl)propoxy]benzenesulfonamide Cn1c(CCCOc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)nc2ccccc21 Degrader C25H21Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-VS7BUI WO2022173805-A1_13 benzyl N-[(1R,3R)-3-[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]phenoxy]cyclohexyl]carbamate O=C(N[C@@H]1CCC[C@@H](Oc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)C1)OCc1ccccc1 Degrader C28H27Cl2N3O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-WLQOSD WO2022173805-A1_14 . NC[C@H]1CC[C@H](Oc2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)CC1 Degrader C21H22Cl2FN3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-0HHCZI WO2022173805-A1_140 . O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(OCCCCc2ccccn2)cc1 Degrader C23H21Cl2N3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-0D7BE1 WO2022173805-A1_143 . CNCCCCCOc1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C20H22Cl2FN3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-JSQDHV WO2022173805-A1_144 N-(3,4-dichloro-1H-indol-7-yl)-4-[5-(methylamino)pentoxy]benzenesulfonamide CNCCCCCOc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C20H23Cl2N3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-HV8319 WO2022173805-A1_148 . CNCCCCCCOc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C21H25Cl2N3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-JYZRO9 WO2022173805-A1_15 . NC[C@H]1CC[C@H](Oc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2)CC1 Degrader C21H23Cl2N3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-ZTYBFS WO2022173805-A1_153 . O=C(NC1CC1)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C18H15Cl2N3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-XWNNLR WO2022173805-A1_154 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[(1S)-2,3-dihydro-1H-inden-1-yl]-2-fluorobenzamide O=C(N[C@H]1CCc2ccccc21)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C24H18Cl2FN3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-Q739Y3 WO2022173805-A1_155 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[(1S)-2,3-dihydro-1H-inden-1-yl]-3-fluorobenzamide O=C(N[C@H]1CCc2ccccc21)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C24H18Cl2FN3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-OCNUZD WO2022173805-A1_156 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[(3S)-6-oxopiperidin-3-yl]benzamide O=C1CC[C@H](NC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)CN1 Degrader C20H17Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-8TWJ91 WO2022173805-A1_157 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[(3S)-6-oxopiperidin-3-yl]benzamide O=C1CC[C@H](NC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)CN1 Degrader C20H17Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-W7F491 WO2022173805-A1_158 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[(3S)-1-methyl-6-oxopiperidin-3-yl]benzamide CN1C[C@@H](NC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)CCC1=O Degrader C21H19Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-X2HRYI WO2022173805-A1_159 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[(3S)-1-methyl-6-oxopiperidin-3-yl]benzamide CN1C[C@@H](NC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)CCC1=O Degrader C21H19Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-P1IAWF WO2022173805-A1_16 N-(3,4-dichloro-1H-indol-7-yl)-3-(4-morpholin-4-ylcyclohexyl)oxybenzenesulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(O[C@H]2CC[C@H](N3CCOCC3)CC2)c1 Degrader C24H27Cl2N3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-SRNMY8 WO2022173805-A1_160 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[(3S)-2-oxoazepan-3-yl]benzamide O=C(N[C@H]1CCCCNC1=O)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C21H19Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-V75K5Y WO2022173805-A1_161 . O=C(N[C@H]1CCCCNC1=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C21H19Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-FU759Q WO2022173805-A1_162 tert-butyl N-[1-[[[3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluorobenzoyl]amino]methyl]cyclopropyl]carbamate CC(C)(C)OC(=O)NC1(CNC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)CC1 Degrader C24H25Cl2FN4O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-LCEEZR WO2022173805-A1_163 tert-butyl N-[1-[[[4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluorobenzoyl]amino]methyl]cyclopropyl]carbamate CC(C)(C)OC(=O)NC1(CNC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)CC1 Degrader C24H25Cl2FN4O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-CS2XDD WO2022173805-A1_164 N-[[(7S)-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl]-3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluorobenzamide O=C(NC[C@H]1Cc2ccccc21)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C24H18Cl2FN3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-E80VQR WO2022173805-A1_165 . O=C(NC[C@H]1Cc2ccccc21)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C24H18Cl2FN3O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-V38P2N WO2022173805-A1_166 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[[1-(3-phenylpropyl)piperidin-4-yl]methyl]benzamide O=C(NCC1CCN(CCCc2ccccc2)CC1)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C30H31Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-QUDJNA WO2022173805-A1_167 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[[1-(3-phenylpropyl)piperidin-4-yl]methyl]benzamide O=C(NCC1CCN(CCCc2ccccc2)CC1)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C30H31Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-3AIOAO WO2022173805-A1_168 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[[3-(2-methylpropanoylamino)phenyl]methyl]benzamide CC(C)C(=O)Nc1cccc(CNC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)c1 Degrader C26H23Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-O1U2QL WO2022173805-A1_169 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[[3-(2-methylpropanoylamino)phenyl]methyl]benzamide CC(C)C(=O)Nc1cccc(CNC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)c1 Degrader C26H23Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-RS0FT0 WO2022173805-A1_17 N-(3,4-dichloro-1H-indol-7-yl)-4-(4-morpholin-4-ylcyclohexyl)oxybenzenesulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(O[C@H]2CC[C@H](N3CCOCC3)CC2)cc1 Degrader C24H27Cl2N3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-F4XG5S WO2022173805-A1_170 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[[4-(diethylcarbamoyl)phenyl]methyl]-2-fluorobenzamide CCN(CC)C(=O)c1ccc(CNC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)cc1 Degrader C27H25Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-4LBBUW WO2022173805-A1_171 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[[4-(diethylcarbamoyl)phenyl]methyl]-3-fluorobenzamide CCN(CC)C(=O)c1ccc(CNC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)cc1 Degrader C27H25Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-3G63BR WO2022173805-A1_172 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[[2-(2-methylphenoxy)phenyl]methyl]benzamide Cc1ccccc1Oc1ccccc1CNC(=O)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C29H22Cl2FN3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-YIYQSN WO2022173805-A1_173 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[[2-(2-methylphenoxy)phenyl]methyl]benzamide Cc1ccccc1Oc1ccccc1CNC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C29H22Cl2FN3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-I2WUBF WO2022173805-A1_174 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[(1,5-dimethylpyrazol-3-yl)methyl]-2-fluorobenzamide Cc1cc(CNC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)nn1C Degrader C21H18Cl2FN5O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-GLKGNY WO2022173805-A1_175 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[(1,5-dimethylpyrazol-3-yl)methyl]-3-fluorobenzamide Cc1cc(CNC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)nn1C Degrader C21H18Cl2FN5O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-9LLV5R WO2022173805-A1_176 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-fluoro-N-methylbenzamide CCc1nc(CN(C)C(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)no1 Degrader C21H18Cl2FN5O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-PN3X5O WO2022173805-A1_177 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-3-fluoro-N-methylbenzamide CCc1nc(CN(C)C(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)no1 Degrader C21H18Cl2FN5O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-ROI7J7 WO2022173805-A1_178 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[(4-methylpyridin-2-yl)methyl]benzamide Cc1ccnc(CNC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)c1 Degrader C22H17Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-M1GWOJ WO2022173805-A1_179 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[(4-methylpyridin-2-yl)methyl]benzamide Cc1ccnc(CNC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)c1 Degrader C22H17Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-IMQDJ9 WO2022173805-A1_18 N-(3,4-dichloro-1H-indol-7-yl)-3-(4-phenylmethoxycyclohexyl)oxybenzenesulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(O[C@H]2CC[C@H](OCc3ccccc3)CC2)c1 Degrader C27H26Cl2N2O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-VJB4KM WO2022173805-A1_180 N-[(S)-cyclopropyl-(4-methylpyridin-2-yl)methyl]-4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluorobenzamide Cc1ccnc([C@@H](NC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)C2CC2)c1 Degrader C25H21Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-0M6C6O WO2022173805-A1_181 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[[6-(3-methoxyphenoxy)pyridin-3-yl]methyl]benzamide COc1cccc(Oc2ccc(CNC(=O)c3cccc(S(=O)(=O)Nc4ccc(Cl)c5c(Cl)c[nH]c45)c3F)cn2)c1 Degrader C28H21Cl2FN4O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-KLOWWK WO2022173805-A1_182 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[[6-(3-methoxyphenoxy)pyridin-3-yl]methyl]benzamide COc1cccc(Oc2ccc(CNC(=O)c3ccc(S(=O)(=O)Nc4ccc(Cl)c5c(Cl)c[nH]c45)c(F)c3)cn2)c1 Degrader C28H21Cl2FN4O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-UOEAGW WO2022173805-A1_183 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[(5-methylpyrazin-2-yl)methyl]benzamide Cc1cnc(CNC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)cn1 Degrader C21H16Cl2FN5O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-LLT6GU WO2022173805-A1_184 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[(5-methylpyrazin-2-yl)methyl]benzamide Cc1cnc(CNC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)cn1 Degrader C21H16Cl2FN5O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-YMUCEI WO2022173805-A1_185 N-[(S)-cyclopropyl-(4-methylpyridin-2-yl)methyl]-3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluorobenzamide Cc1ccnc([C@@H](NC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)C2CC2)c1 Degrader C25H21Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-SMV3AF WO2022173805-A1_186 N-[2-(cyclopropylmethoxy)ethyl]-3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluorobenzamide O=C(NCCOCC1CC1)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C21H20Cl2FN3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-DWYGMW WO2022173805-A1_187 N-[2-(cyclopropylmethoxy)ethyl]-4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluorobenzamide O=C(NCCOCC1CC1)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C21H20Cl2FN3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-D4AP3K WO2022173805-A1_188 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[2-(1,1-dioxothian-4-yl)oxyethyl]-2-fluorobenzamide O=C(NCCOC1CCS(=O)(=O)CC1)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C22H22Cl2FN3O6S2 RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-2DEBWE WO2022173805-A1_189 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[2-(1,1-dioxothian-4-yl)oxyethyl]-3-fluorobenzamide O=C(NCCOC1CCS(=O)(=O)CC1)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C22H22Cl2FN3O6S2 RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-NGWP0H WO2022173805-A1_19 N-(3,4-dichloro-1H-indol-7-yl)-4-(4-phenylmethoxycyclohexyl)oxybenzenesulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc(O[C@H]2CC[C@H](OCc3ccccc3)CC2)cc1 Degrader C27H26Cl2N2O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-K84UTJ WO2022173805-A1_190 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-(2-ethylsulfonylethyl)-2-fluorobenzamide CCS(=O)(=O)CCNC(=O)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C19H18Cl2FN3O5S2 RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-LP28PW WO2022173805-A1_191 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-(2-ethylsulfonylethyl)-3-fluorobenzamide CCS(=O)(=O)CCNC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C19H18Cl2FN3O5S2 RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-0N07Y5 WO2022173805-A1_192 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[2-(1-methylazetidin-3-yl)ethyl]benzamide CN1CC(CCNC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)C1 Degrader C21H21Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-LVU1W8 WO2022173805-A1_193 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[2-(1-methylazetidin-3-yl)ethyl]benzamide CN1CC(CCNC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)C1 Degrader C21H21Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-VTO2VZ WO2022173805-A1_194 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[2-[4-(dimethylcarbamoyl)phenyl]ethyl]-2-fluorobenzamide CN(C)C(=O)c1ccc(CCNC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)cc1 Degrader C26H23Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-3EZSOM WO2022173805-A1_195 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[2-[4-(dimethylcarbamoyl)phenyl]ethyl]-3-fluorobenzamide CN(C)C(=O)c1ccc(CCNC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)cc1 Degrader C26H23Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-ZDXW63 WO2022173805-A1_196 . CN(C)C(=O)CC(NC(=O)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F)c1ccccc1 Degrader C26H23Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-HVT14V WO2022173805-A1_197 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-N-[(1S)-3-(dimethylamino)-3-oxo-1-phenylpropyl]-3-fluorobenzamide CN(C)C(=O)C[C@H](NC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1)c1ccccc1 Degrader C26H23Cl2FN4O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-QJF8FQ WO2022173805-A1_198 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[2-(5-methylfuran-2-yl)ethyl]benzamide Cc1ccc(CCNC(=O)c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c2F)o1 Degrader C22H18Cl2FN3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-V5BW9C WO2022173805-A1_199 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[2-(5-methylfuran-2-yl)ethyl]benzamide Cc1ccc(CCNC(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)o1 Degrader C22H18Cl2FN3O4S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-BOH3LE WO2022173805-A1_2 N-(3,4-dichloro-1H-indol-7-yl)-2-fluoro-4-(4-methylsulfonylcyclohexyl)oxybenzenesulfonamide CS(=O)(=O)[C@H]1CC[C@H](Oc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)c(F)c2)CC1 Degrader C21H21Cl2FN2O5S2 RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-3Z9LDE WO2022173805-A1_20 3-[[(1R,5S)-3-bicyclo[3.1.0]hexanyl]oxy]-N-(3,4-dichloro-1H-indol-7-yl)benzenesulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1cccc(O[C@@H]2C[C@@H]3C[C@@H]3C2)c1 Degrader C20H18Cl2N2O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-P4I7ZZ WO2022173805-A1_200 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-(2-pyridin-2-ylethyl)benzamide O=C(NCCc1ccccn1)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C22H17Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-P10OD5 WO2022173805-A1_201 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-(2-pyridin-2-ylethyl)benzamide O=C(NCCc1ccccn1)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C22H17Cl2FN4O3S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-VPOAR6 WO2022173805-A1_202 3-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-2-fluoro-N-[3-(2-methoxyethoxy)propyl]benzamide COCCOCCCNC(=O)c1cccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c1F Degrader C21H22Cl2FN3O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-GYBKQI WO2022173805-A1_203 4-[(3,4-dichloro-1H-indol-7-yl)sulfamoyl]-3-fluoro-N-[3-(2-methoxyethoxy)propyl]benzamide COCCOCCCNC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c(F)c1 Degrader C21H22Cl2FN3O5S RBM39 Q14498 DCAF15 WO-2022173805-A1 TPD-LJL6E5 6-Chloro-7-bromo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one SCHEMBL1571257; CHEMBL5267706; WOMVONYQNTYHEW-UHFFFAOYSA-N; 6-Chloro-7-bromo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one O=C1CN2Cc3c(ccc(Br)c3Cl)N=C2N1 Stabilizer C10H7BrClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-A0TWL8 6-chloro-7-pyridin-4-yl-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one CHEMBL5287101 O=C1CN2Cc3c(ccc(-c4ccncc4)c3Cl)N=C2N1 Stabilizer C15H11ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-C1ABF2 WO2022199627-A1_A11 . O=C1CN2Cc3c(ccc(-c4ccc5ccccc5c4)c3Cl)N=C2N1 Stabilizer C20H14ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-8KRN6V CHEMBL5283000 4-(6-chloro-2-oxo-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-7-yl)benzonitrile\; CHEMBL5283000 N#Cc1ccc(-c2ccc3c(c2Cl)CN2CC(=O)NC2=N3)cc1 Stabilizer C17H11ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-67CEJ4 CHEMBL5288674 6-chloro-7-(4-hydroxyphenyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one\; CHEMBL5288674 O=C1CN2Cc3c(ccc(-c4ccc(O)cc4)c3Cl)N=C2N1 Stabilizer C16H12ClN3O2 PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-EPM2LQ Dechloro Anagrelide Dechloro Anagrelide; 61834-95-5; 6-chloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one; 6-chloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one; RFUZAPDLTCFPQE-UHFFFAOYSA-N; SCHEMBL7306463; CHEMBL5274826; ID139092; 6-chloro-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one O=C1CN2Cc3c(Cl)cccc3N=C2N1 Stabilizer C10H8ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-V7K9Z5 6,8-dichloro-7-phenyl-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one CHEMBL5290413 O=C1CN2Cc3c(cc(Cl)c(-c4ccccc4)c3Cl)N=C2N1 Stabilizer C16H11Cl2N3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-80FY3E WO2022199627-A1_A16 . O=C1CN2Cc3c(ccc(-c4ccc(C(=O)O)cc4)c3Cl)N=C2N1 Stabilizer C17H12ClN3O3 PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-9ZG8M9 WO2022199627-A1_A17 . O=C1CN2Cc3c(cc(Cl)c(Br)c3Cl)N=C2N1 Stabilizer C10H6BrCl2N3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-KRB47R CHEMBL5272944 6-chloro-7-(2-methylphenyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one\; CHEMBL5272944 Cc1ccccc1-c1ccc2c(c1Cl)CN1CC(=O)NC1=N2 Stabilizer C17H14ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-NMYYIQ CHEMBL5274395 6-chloro-7-(3-methylphenyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one\; CHEMBL5274395 Cc1cccc(-c2ccc3c(c2Cl)CN2CC(=O)NC2=N3)c1 Stabilizer C17H14ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-7IV98Z 6-chloro-7-fluoro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one CHEMBL5286462 O=C1CN2Cc3c(ccc(F)c3Cl)N=C2N1 Stabilizer C10H7ClFN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-LWD5RA CHEMBL5276956 6-chloro-7-(4-ethylphenyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one\; CHEMBL5276956 CCc1ccc(-c2ccc3c(c2Cl)CN2CC(=O)NC2=N3)cc1 Stabilizer C18H16ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-5MSCSN WO2022199627-A1_A21 . CCCc1ccc(-c2ccc3c(c2Cl)CN2CC(=O)NC2=N3)cc1 Stabilizer C19H18ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-Y8MU3M WO2022199627-A1_A22 . CC(C)c1ccc(-c2ccc3c(c2Cl)CN2CC(=O)NC2=N3)cc1 Stabilizer C19H18ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-NDUIRO WO2022199627-A1_A23 . CCCCNc1ccc2c(c1Cl)CN1CC(=O)NC1=N2 Stabilizer C14H17ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-LOCE4Z WO2022199627-A1_A24 . O=C1CN2Cc3c(ccc(NCc4ccccc4)c3Cl)N=C2N1 Stabilizer C17H15ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-APM0BW WO2022199627-A1_A25 . O=C1CN2Cc3c(ccc(NC4CCCC4)c3Cl)N=C2N1 Stabilizer C15H17ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-NBKHRL WO2022199627-A1_A26 . O=C1CN2Cc3c(ccc(NC4CCCCC4)c3Cl)N=C2N1 Stabilizer C16H19ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-4F6VDM CHEMBL31649 6-chloro-7-pyrrolidin-1-yl-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one\; CHEMBL31649; SCHEMBL10605681 O=C1CN2Cc3c(ccc(N4CCCC4)c3Cl)N=C2N1 Stabilizer C14H15ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-NPN4Y1 CHEMBL31701 6-chloro-7-piperidin-1-yl-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one\; CHEMBL31701 O=C1CN2Cc3c(ccc(N4CCCCC4)c3Cl)N=C2N1 Stabilizer C15H17ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-WDWLD7 CHEMBL32456 6-chloro-7-(4-methylpiperidin-1-yl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one\; CHEMBL32456 CC1CCN(c2ccc3c(c2Cl)CN2CC(=O)NC2=N3)CC1 Stabilizer C16H19ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-X7WQIA WO2022199627-A1_A3 . C=Cc1ccc2c(c1Cl)CN1CC(=O)NC1=N2 Stabilizer C12H10ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-ZAWRHR WO2022199627-A1_A33 . C=CCc1ccc2c(c1Cl)CN1CC(=O)NC1=N2 Stabilizer C13H12ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-VE9P3X WO2022199627-A1_A34 . O=C1CN2Cc3c(ccc(-c4ccc(F)cc4)c3Cl)N=C2N1 Stabilizer C16H11ClFN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-75QTVB CHEMBL5265970 6-chloro-7-(4-chlorophenyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one\; CHEMBL5265970 O=C1CN2Cc3c(ccc(-c4ccc(Cl)cc4)c3Cl)N=C2N1 Stabilizer C16H11Cl2N3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-828122 WO2022199627-A1_A36 . O=C1CN2Cc3c(ccc(-c4ccc(C(F)(F)F)cc4)c3Cl)N=C2N1 Stabilizer C17H11ClF3N3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-47XD2R WO2022199627-A1_A37 . O=C1CN2Cc3c(ccc(N4CCCCCC4)c3Cl)N=C2N1 Stabilizer C16H19ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2022199627-A1 TPD-7SK0W6 WO2022257897-A1_10 . O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ccc(F)cc4)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H22FN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-NY4ZN8 WO2022257897-A1_11 . O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ccccc4F)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H22FN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-45D5EA WO2022257897-A1_12 . O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ccccc4Cl)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H22ClN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-QNPGJU WO2022257897-A1_13 . O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ccc(F)cc4Cl)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H21ClFN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-VZXV7N WO2022257897-A1_14 N-[(4-chloro-2-fluorophenyl)-cyclopropylmethyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide O=C1CCC(N2Cc3cc(C(=O)NC(c4ccc(Cl)cc4F)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H21ClFN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-F74CCF SCHEMBL24742266 N-[cyclopropyl-(2-methoxyphenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742266 COc1ccccc1C(NC(=O)c1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CC1 Degrader C25H25N3O5 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-M1F3XP SCHEMBL24742260 N-[(3-chloropyridin-2-yl)-cyclopropylmethyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742260 O=C1CCC(N2Cc3cc(C(=O)NC(c4ncccc4Cl)C4CC4)ccc3C2=O)C(=O)N1 Degrader C23H21ClN4O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-6EJIF1 SCHEMBL24742256 N-[(S)-cyclopropyl-(2,6-difluorophenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742256 O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4c(F)cccc4F)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H21F2N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-X2NQ83 SCHEMBL24742090 N-[(S)-(3-chloropyridin-2-yl)-cyclobutylmethyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742090 O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ncccc4Cl)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C24H23ClN4O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-ZP4BEC WO2022257897-A1_19 . O=C1CCC(N2Cc3cc(C(=O)NC(c4ccc(F)cc4Cl)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C25H23ClFN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-LKOP9N SCHEMBL24742784 N-[(4-chloro-2-fluorophenyl)-cyclobutylmethyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742784 O=C1CCC(N2Cc3cc(C(=O)NC(c4ccc(Cl)cc4F)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C25H23ClFN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-9D0I1T WO2022257897-A1_21 . CN1CCN(c2ccc([C@@H](NC(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C3CCC3)cc2)CC1 Degrader C30H35N5O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-YB8I9Q SCHEMBL24742789 N-[cyclobutyl-(2,6-difluorophenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742789 O=C1CCC(N2Cc3cc(C(=O)NC(c4c(F)cccc4F)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C25H23F2N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-HNDXBV SCHEMBL24741631 N-[cyclobutyl-(3-fluorophenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24741631 O=C1CCC(N2Cc3cc(C(=O)NC(c4cccc(F)c4)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C25H24FN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-FHVW5F WO2022257897-A1_24 . O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ccccc4F)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C25H24FN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-Y1Y9X2 WO2022257897-A1_25 . O=C1CCC(N2Cc3cc(C(=O)N[C@@H](c4cccc(F)c4)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H22FN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-MUR5PM WO2022257897-A1_26 . O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4cccc(F)c4)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H22FN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-35XMTZ SCHEMBL24741694 N-[(R)-(3-chlorophenyl)-cyclopropylmethyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24741694 O=C1CCC(N2Cc3cc(C(=O)N[C@@H](c4cccc(Cl)c4)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H22ClN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-QYL4N0 SCHEMBL24741697 N-[(S)-(3-chlorophenyl)-cyclopropylmethyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24741697 O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4cccc(Cl)c4)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H22ClN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-2GOQU4 SCHEMBL24741700 N-[(R)-cyclopropyl-(3-methylphenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24741700 Cc1cccc([C@H](NC(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C2CC2)c1 Degrader C25H25N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-DW1P9V SCHEMBL24741698 N-[(S)-cyclopropyl-(3-methylphenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24741698 Cc1cccc([C@@H](NC(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C2CC2)c1 Degrader C25H25N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-8LXMKY SCHEMBL24741591 N-[(R)-cyclopropyl-(3-methoxyphenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24741591 COc1cccc([C@H](NC(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C2CC2)c1 Degrader C25H25N3O5 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-4VE7P7 SCHEMBL24741590 N-[(S)-cyclopropyl-(3-methoxyphenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24741590 COc1cccc([C@@H](NC(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C2CC2)c1 Degrader C25H25N3O5 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-1RHPC4 SCHEMBL24741592 N-[(R)-cyclopropyl-[3-(trifluoromethyl)phenyl]methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24741592 O=C1CCC(N2Cc3cc(C(=O)N[C@@H](c4cccc(C(F)(F)F)c4)C4CC4)ccc3C2=O)C(=O)N1 Degrader C25H22F3N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-V3K0RL WO2022257897-A1_34 . O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4cccc(C(F)(F)F)c4)C4CC4)ccc3C2=O)C(=O)N1 Degrader C25H22F3N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-BD649Y WO2022257897-A1_35 . O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ccc(Cl)cc4)C4CC(F)(F)C4)ccc3C2=O)C(=O)N1 Degrader C25H22ClF2N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-EX4VZ6 WO2022257897-A1_36 . O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ccc(Cl)cc4)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C25H24ClN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-PS0L35 WO2022257897-A1_37 N-[cyclopentyl-(4-fluorophenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide O=C1CCC(N2Cc3cc(C(=O)NC(c4ccc(F)cc4)C4CCCC4)ccc3C2=O)C(=O)N1 Degrader C26H26FN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-UUB85A SCHEMBL24742320 2-(2,6-dioxopiperidin-3-yl)-N-[(S)-(4-fluorophenyl)-(oxan-4-yl)methyl]-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742320 O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ccc(F)cc4)C4CCOCC4)ccc3C2=O)C(=O)N1 Degrader C26H26FN3O5 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-QYJFMQ WO2022257897-A1_39 . Cc1ccccc1[C@@H](NC(=O)c1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CC1 Degrader C25H25N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-UFJ4SF SCHEMBL24742356 N-[cyclobutyl-(3,4-difluorophenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742356 O=C1CCC(N2Cc3cc(C(=O)NC(c4ccc(F)c(F)c4)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C25H23F2N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-MR1TFK SCHEMBL24742355 N-[(S)-cyclobutyl-(2,4-difluorophenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742355 O=C1CCC(N2Cc3cc(C(=O)N[C@H](c4ccc(F)cc4F)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C25H23F2N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-8I7DSU SCHEMBL24742359 N-[(R)-cyclobutyl-(2,4-difluorophenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742359 O=C1CCC(N2Cc3cc(C(=O)N[C@@H](c4ccc(F)cc4F)C4CCC4)ccc3C2=O)C(=O)N1 Degrader C25H23F2N3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-G75PM3 SCHEMBL24742102 N-[(2-chloro-3-fluorophenyl)-cyclopropylmethyl]-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL24742102 O=C1CCC(N2Cc3cc(C(=O)NC(c4cccc(F)c4Cl)C4CC4)ccc3C2=O)C(=O)N1 Degrader C24H21ClFN3O4 GSPT1;CK1α P15170/P48729 CRBN WO-2022257897-A1 TPD-161M4N WO2023025112-A1_1 (4aR)-3-[[4-[[1-(2,6-dioxopiperidin-3-yl)-4-fluoro-2-oxobenzo[cd]indol-6-yl]methyl]phenyl]methyl]-2,4,4a,5-tetrahydro-1H-pyrazino[2,1-c][1,4]benzoxazine-8-carbonitrile N#Cc1ccc2c(c1)OC[C@H]1CN(Cc3ccc(Cc4ccc5c6c(cc(F)cc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CCN21 Degrader C36H30FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-0C3AC0 SCHEMBL27458657 (10R)-12-[[4-[[1-(2,6-dioxopiperidin-3-yl)-4-fluoro-2-oxobenzo[cd]indol-6-yl]methyl]-3-fluorophenyl]methyl]-8-oxa-1,3,12-triazatricyclo[8.4.0.02,7]tetradeca-2(7),3,5-triene-5-carbonitrile\; SCHEMBL27458657 N#Cc1cnc2c(c1)OC[C@H]1CN(Cc3ccc(Cc4ccc5c6c(cc(F)cc46)C(=O)N5C4CCC(=O)NC4=O)c(F)c3)CCN21 Degrader C35H28F2N6O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-CCZCK1 SCHEMBL27453393 3-[4-Fluoro-6-[[2-fluoro-4-[(4-morpholin-4-ylpiperidin-1-yl)methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione\; SCHEMBL27453393 O=C1CCC(N2C(=O)c3cc(F)cc4c(Cc5ccc(CN6CCC(N7CCOCC7)CC6)cc5F)ccc2c34)C(=O)N1 Degrader C33H34F2N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-VLH3GB SCHEMBL27453469 3-[4-Fluoro-6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione\; SCHEMBL27453469 O=C1CCC(N2C(=O)c3cc(F)cc4c(Cc5ccc(CN6CCOCC6)cc5)ccc2c34)C(=O)N1 Degrader C28H26FN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-GUHO5O SCHEMBL27453491 3-[6-[[4-[(4-Tert-butylpiperazin-1-yl)methyl]-2-fluorophenyl]methyl]-4-fluoro-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione\; SCHEMBL27453491 CC(C)(C)N1CCN(Cc2ccc(Cc3ccc4c5c(cc(F)cc35)C(=O)N4C3CCC(=O)NC3=O)c(F)c2)CC1 Degrader C32H34F2N4O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-M53XSE SCHEMBL27453570 4-[4-[[4-[[1-(2,6-Dioxopiperidin-3-yl)-5-fluoro-2-oxobenzo[cd]indol-6-yl]methyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile\; SCHEMBL27453570 N#Cc1ccc(N2CCN(Cc3ccc(Cc4ccc5c6c(ccc(F)c46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)c(F)c1 Degrader C35H29F2N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-W3WJUM SCHEMBL27453563 4-[4-[[4-[[1-(2,6-Dioxopiperidin-3-yl)-3-fluoro-2-oxobenzo[cd]indol-6-yl]methyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile\; SCHEMBL27453563 N#Cc1ccc(N2CCN(Cc3ccc(Cc4ccc5c6c(c(F)ccc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)c(F)c1 Degrader C35H29F2N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-HZNP5F SCHEMBL27453561 4-[4-[[4-[[4-Bromo-1-(2,6-dioxopiperidin-3-yl)-2-oxobenzo[cd]indol-6-yl]methyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile\; SCHEMBL27453561 N#Cc1ccc(N2CCN(Cc3ccc(Cc4ccc5c6c(cc(Br)cc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)c(F)c1 Degrader C35H29BrFN5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-LQD8AT SCHEMBL27453559 4-[4-[[4-[[4-Chloro-1-(2,6-dioxopiperidin-3-yl)-2-oxobenzo[cd]indol-6-yl]methyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile\; SCHEMBL27453559 N#Cc1ccc(N2CCN(Cc3ccc(Cc4ccc5c6c(cc(Cl)cc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)c(F)c1 Degrader C35H29ClFN5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-Z7BUH2 SCHEMBL27454412 4-[4-[[4-[[1-(2,6-Dioxopiperidin-3-yl)-2-oxobenzo[cd]indol-6-yl]methyl]-3-fluorophenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile\; SCHEMBL27454412 N#Cc1ccc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5C4CCC(=O)NC4=O)c(F)c3)CC2)c(F)c1 Degrader C35H29F2N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-18PNIG WO2023025112-A1_2 (4aR)-3-[[5-[[1-(2,6-dioxopiperidin-3-yl)-4-fluoro-2-oxobenzo[cd]indol-6-yl]methyl]pyridin-2-yl]methyl]-2,4,4a,5-tetrahydro-1H-pyrazino[2,1-c][1,4]benzoxazine-8-carbonitrile N#Cc1ccc2c(c1)OC[C@H]1CN(Cc3ccc(Cc4ccc5c6c(cc(F)cc46)C(=O)N5C4CCC(=O)NC4=O)cn3)CCN21 Degrader C35H29FN6O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025112-A1 TPD-BSDGZZ WO2023025136-A1_1 . N#Cc1ccc2c(c1)OCC1CN(Cc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3)CCN21 Degrader C33H31N5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025136-A1 TPD-XFS2HA WO2023025136-A1_10 . N#Cc1cnc2c(c1)OC[C@H]1CN(Cc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)CCN21 Degrader C32H30N6O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025136-A1 TPD-DUTBDO WO2023025136-A1_10_A . N#Cc1cnc2c(c1)OC[C@H]1CN(Cc3ccc(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)cc3)CCN21 Degrader C32H30N6O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025136-A1 TPD-80TC9C WO2023025136-A1_10_B . N#Cc1cnc2c(c1)OC[C@H]1CN(Cc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3)CCN21 Degrader C32H30N6O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025136-A1 TPD-NW83OI WO2023025136-A1_11_A . N#Cc1cnc2c(c1)OC[C@H]1CN(Cc3ccc(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)c(F)c3)CCN21 Degrader C32H29FN6O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025136-A1 TPD-PO9VUW WO2023025136-A1_11_B . N#Cc1cnc2c(c1)OC[C@H]1CN(Cc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)c(F)c3)CCN21 Degrader C32H29FN6O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025136-A1 TPD-99IZNZ WO2023025136-A1_12 . N#Cc1cnc2c(c1)OC[C@H]1CN(Cc3ccc(COc4cc(F)cc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3)CCN21 Degrader C32H29FN6O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025136-A1 TPD-V5BK4O WO2023025136-A1_1_A . N#Cc1ccc2c(c1)OC[C@H]1CN(Cc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3)CCN21 Degrader C33H31N5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025136-A1 TPD-WDKMKP WO2023025136-A1_1_B . N#Cc1ccc2c(c1)OC[C@@H]1CN(Cc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3)CCN21 Degrader C33H31N5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023025136-A1 TPD-VFOKTQ [(4-Acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride 2172794-56-6; [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride; ((4-acetamidophenyl)(fluorosulfonyl)amino)sulfonyl fluoride; 840-843-9; (4-Acetamidophenyl)(fluorosulfonyl)sulfamoyl fluoride; Aisf; (4-Acetamidophenyl)(fluorosulfonyl)sulfamoylfluoride; N-(4-acetamidophenyl)-N-fluorosulfonylsulfamoyl fluoride; 4-(Acetylamino)phenyl]imidodisulfuryl difluoride; MFCD31625434; C8H8F2N2O5S2; SCHEMBL20720013; AC5609; AKOS040767043; BS-52453; SY249732; CS-0149204; [4-(acetylamino)phenyl]imidodisulfuryl difluoride; EN300-6745900; 4-(Acetylamino)phenyl]imidodisulfuryl difluoride, >=98%; N-(4-acetamidophenyl)-N-fluorosulfonyl-sulfamoyl fluoride CC(=O)Nc1ccc(N(S(=O)(=O)F)S(=O)(=O)F)cc1 Degrader C8H8F2N2O5S2 GSPT1 P15170 CRBN WO-2023056443-A1 TPD-WVHFRJ WO2023056443-A1_10 7-amino-2-(2,6-dioxopiperidin-3-yl)-5-fluorosulfonyloxy-3-oxo-1H-isoindole Nc1cc(OS(=O)(=O)F)cc2c1CN(C1CCC(=O)NC1=O)C2=O Degrader C13H12FN3O6S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-A3A4KL CHEMBL5421432 3-[5-(4-methylpyrazol-1-yl)sulfonyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; CHEMBL5421432; BDBM50630775 Cc1cnn(S(=O)(=O)c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)c1 Degrader C17H16N4O5S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-0LK8QO CHEMBL5415133 3-[5-(4-fluoropyrazol-1-yl)sulfonyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; CHEMBL5415133; BDBM50630777 O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cc(F)cn4)cc3C2=O)C(=O)N1 Degrader C16H13FN4O5S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-LGV206 CHEMBL5430120 3-[3-oxo-5-[4-(trifluoromethyl)pyrazol-1-yl]sulfonyl-1H-isoindol-2-yl]piperidine-2,6-dione\; CHEMBL5430120; BDBM50630779 O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cc(C(F)(F)F)cn4)cc3C2=O)C(=O)N1 Degrader C17H13F3N4O5S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-0KGQ15 CHEMBL5431074 3-[3-oxo-5-[4-(trifluoromethyl)imidazol-1-yl]sulfonyl-1H-isoindol-2-yl]piperidine-2,6-dione\; CHEMBL5431074; BDBM50630774 O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cnc(C(F)(F)F)c4)cc3C2=O)C(=O)N1 Degrader C17H13F3N4O5S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-UWED8B CHEMBL5413999 3-[5-(3-fluoropyrazol-1-yl)sulfonyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; CHEMBL5413999; BDBM50630776 O=C1CCC(N2Cc3ccc(S(=O)(=O)n4ccc(F)n4)cc3C2=O)C(=O)N1 Degrader C16H13FN4O5S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-WETNFY CHEMBL5399248 3-[5-(4-methylimidazol-1-yl)sulfonyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; CHEMBL5399248; BDBM50630772 Cc1cn(S(=O)(=O)c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cn1 Degrader C17H16N4O5S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-7VIIBW CHEMBL5429393 3-[5-(4-fluoroimidazol-1-yl)sulfonyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; CHEMBL5429393; BDBM50630773 O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cnc(F)c4)cc3C2=O)C(=O)N1 Degrader C16H13FN4O5S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-J37P6E CHEMBL5419977 3-[3-oxo-5-[3-(trifluoromethyl)pyrazol-1-yl]sulfonyl-1H-isoindol-2-yl]piperidine-2,6-dione\; CHEMBL5419977; BDBM50630778 O=C1CCC(N2Cc3ccc(S(=O)(=O)n4ccc(C(F)(F)F)n4)cc3C2=O)C(=O)N1 Degrader C17H13F3N4O5S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-JEG785 CHEMBL5397937 1-[[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]sulfonyl]-5-methylpyrimidine-2,4-dione\; CHEMBL5397937; BDBM50630780 Cc1cn(S(=O)(=O)c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)c(=O)[nH]c1=O Degrader C18H16N4O7S GSPT1 P15170 CRBN WO-2023056443-A1 TPD-LFPZ31 WO2023059899-A1_1 . Cc1c(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)oc2ccc(F)cc12 Degrader C17H11Cl2FN2O3S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-XC4W8H N-(3,4-dichloro-1H-indol-7-yl)-3-oxo-1H-2-benzofuran-5-sulfonamide BDBM708590; US20240425486, Compound 10 O=C1OCc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc21 Degrader C16H10Cl2N2O4S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-I96YUR N-(3,4-dichloro-1H-indol-7-yl)-1-benzofuran-5-sulfonamide BDBM708591; US20240425486, Compound 11 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc2occc2c1 Degrader C16H10Cl2N2O3S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-ZJHFVM US20240425486, Compound 12 1-acetyl-N-(3,4-dichloro-1H-indol-7-yl)-2,3-dihydroindole-5-sulfonamide\; BDBM708592; US20240425486, Compound 12 CC(=O)N1CCc2cc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)ccc21 Degrader C18H15Cl2N3O3S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-KRA1NB WO2023059899-A1_13 N-(3,4-dichloro-1H-indol-7-yl)-1-propanoyl-2,3-dihydroindole-6-sulfonamide CCC(=O)N1CCc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc21 Degrader C19H17Cl2N3O3S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-15R6WA N-(3,4-dichloro-1H-indol-7-yl)-2,3-dioxo-1H-indole-5-sulfonamide BDBM708593; US20240425486, Compound 14 O=C1Nc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2C1=O Degrader C16H9Cl2N3O4S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-KW073A US20240425486, Compound 15 2-acetyl-N-(3,4-dichloro-1H-indol-7-yl)-1,3-dihydroisoindole-5-sulfonamide\; BDBM708594; US20240425486, Compound 15 CC(=O)N1Cc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2C1 Degrader C18H15Cl2N3O3S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-BKPNBB US20240425486, Compound 16 N-(3,4-dichloro-1H-indol-7-yl)-2-methyl-1,3-dioxoisoindole-5-sulfonamide\; BDBM708595; US20240425486, Compound 16 CN1C(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2C1=O Degrader C17H11Cl2N3O4S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-ADW1EH US20240425486, Compound 17 N-(3,4-dichloro-1H-indol-7-yl)-2,2-dioxo-1,3-dihydro-2-benzothiophene-5-sulfonamide\; BDBM708596; US20240425486, Compound 17 O=S1(=O)Cc2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2C1 Degrader C16H12Cl2N2O4S2 RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-E4NR5O US20240425486, Compound 18 N-(3,4-dichloro-1H-indol-7-yl)-2,2-difluoro-1,3-benzodioxole-5-sulfonamide\; BDBM708597; US20240425486, Compound 18 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc2c(c1)OC(F)(F)O2 Degrader C15H8Cl2F2N2O4S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-RSODC6 US20240425486, Compound 19 N-(3,4-dichloro-1H-indol-7-yl)-1,3-dimethyl-2-oxobenzimidazole-5-sulfonamide\; BDBM708598; US20240425486, Compound 19 Cn1c(=O)n(C)c2cc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)ccc21 Degrader C17H14Cl2N4O3S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-VBK4RC N-(3,4-dichloro-1H-indol-7-yl)-1-methylindole-3-sulfonamide 0 Cn1cc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)c2ccccc21 Degrader C17H13Cl2N3O2S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-GZPJJB N-(3,4-dichloro-1H-indol-7-yl)-2-phenyl-3H-benzimidazole-5-sulfonamide 0 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc2[nH]c(-c3ccccc3)nc2c1 Degrader C21H14Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-YCMZ97 N-(3,4-dichloro-1H-indol-7-yl)-2-oxo-3H-1,3-benzoxazole-6-sulfonamide 0 O=c1[nH]c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc2o1 Degrader C15H9Cl2N3O4S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-R1LQ9O US20240425486, Compound 22 N-(3,4-dichloro-1H-indol-7-yl)-3-methyl-2-oxo-1,3-benzoxazole-6-sulfonamide\; BDBM708599; US20240425486, Compound 22 Cn1c(=O)oc2cc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)ccc21 Degrader C16H11Cl2N3O4S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-YVYMD3 US20240425486, Compound 23 N-(3,4-dichloro-1H-indol-7-yl)-1,1,3-trioxo-1,2-benzothiazole-5-sulfonamide\; BDBM708600; US20240425486, Compound 23 O=C1NS(=O)(=O)c2ccc(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cc21 Degrader C15H9Cl2N3O5S2 RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-WVZF06 WO2023059899-A1_24 N-(3,4-dichloro-1H-indol-7-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc2c(c1)CCCC2 Degrader C18H16Cl2N2O2S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-PEKDFQ N-(3,4-dichloro-1H-indol-7-yl)-1-fluoronaphthalene-2-sulfonamide BDBM708601; US20240425486, Compound 25 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc2ccccc2c1F Degrader C18H11Cl2FN2O2S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-TO1QIM 8-chloro-N-(3,4-dichloro-1H-indol-7-yl)naphthalene-2-sulfonamide 0 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc2cccc(Cl)c2c1 Degrader C18H11Cl3N2O2S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-F3YU0B WO2023059899-A1_27 N-(3,4-dichloro-1H-indol-7-yl)-5-(dimethylamino)naphthalene-1-sulfonamide CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)c4c(Cl)c[nH]c34)cccc12 Degrader C20H17Cl2N3O2S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-FX6WHM 5,8-dichloro-N-(3,4-dichloro-1H-indol-7-yl)naphthalene-2-sulfonamide 0 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc2c(Cl)ccc(Cl)c2c1 Degrader C18H10Cl4N2O2S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-2K2XRB US20240425486, Compound 29 (2S)-N-(3,4-dichloro-1H-indol-7-yl)-2-(difluoromethyl)-3,4-dihydro-2H-chromene-6-sulfonamide\; BDBM708602; US20240425486, Compound 29 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)c1ccc2c(c1)CC[C@@H](C(F)F)O2 Degrader C18H14Cl2F2N2O3S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-2BRMDE N-(3,4-dichloro-1H-indol-7-yl)-1,3-dihydroisoindole-2-sulfonamide 0 O=S(=O)(Nc1ccc(Cl)c2c(Cl)c[nH]c12)N1Cc2ccccc2C1 Degrader C16H13Cl2N3O2S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-D27TEZ WO2023059899-A1_30 . Cc1c[nH]c2c(NS(=O)(=O)c3ccc4c(c3)C(=O)CCO4)ccc(Cl)c12 Degrader C18H15ClN2O4S RBM39 Q14498 DCAF15 WO-2023059899-A1 TPD-PGKIMA WO2023064058-A1_1 6,7-dichloro-3-(2-methoxyethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide COCCN1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C12H13Cl2N3O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-8LA5VJ SCHEMBL25149614 7-Chloro-3-propyl-1,3,4,9-tetrahydropyrrolo[3,2-h][2,1]benzothiazine 2,2-dioxide\; SCHEMBL25149614 CCCC1Cc2ccc3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C13H15ClN2O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-ACH7L4 SCHEMBL25150424 3-(2-methoxyethyl)-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine-7-carbonitrile\; SCHEMBL25150424 COCCN1Cc2ccc3c(C#N)c[nH]c3c2NS1(=O)=O Degrader C13H14N4O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-SI8708 WO2023064058-A1_11 6,7-dichloro-3-[(3-chlorophenyl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1cccc(Cl)c1 Degrader C16H12Cl3N3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-CHJ30A SCHEMBL25149579 6,7-dichloro-3-[(6-chloropyridin-3-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25149579 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1ccc(Cl)nc1 Degrader C15H11Cl3N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-DFHSPF WO2023064058-A1_13 6,7-dichloro-3-[(4-chlorophenyl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1ccc(Cl)cc1 Degrader C16H12Cl3N3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-4R7HI3 WO2023064058-A1_14 6,7-dichloro-3-[(2-chlorophenyl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1ccccc1Cl Degrader C16H12Cl3N3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-0Q4J1E WO2023064058-A1_15 6,7-dichloro-3-methyl-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide CN1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C10H9Cl2N3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-F1ZLEN SCHEMBL25149430 3-Benzyl-6,7-dichloro-1,3,4,9-tetrahydropyrrolo[3,2-h][2,1]benzothiazine 2,2-dioxide\; SCHEMBL25149430 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CC1Cc1ccccc1 Degrader C17H14Cl2N2O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-DWX30Z SCHEMBL25150437 5-[(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)methyl]-1H-pyridin-2-one\; SCHEMBL25150437 O=c1ccc(CN2Cc3cc(Cl)c4c(Cl)c[nH]c4c3NS2(=O)=O)c[nH]1 Degrader C15H12Cl2N4O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-4VEOFU SCHEMBL25150476 6,7-dichloro-3-(4-fluorobutyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25150476 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1CCCCF Degrader C13H14Cl2FN3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-LK1NZ8 WO2023064058-A1_19 6,7-dichloro-3-(pyridin-2-ylmethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1ccccn1 Degrader C15H12Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-9VMM4S WO2023064058-A1_2 6-chloro-3-(2-methoxyethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide COCCN1Cc2cc(Cl)c3cc[nH]c3c2NS1(=O)=O Degrader C12H14ClN3O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-CCJ0TI WO2023064058-A1_20 6,7-dichloro-3-(pyridin-4-ylmethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1ccncc1 Degrader C15H12Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-HWR91L WO2023064058-A1_21 6,7-dichloro-3-[(6-methoxypyridin-3-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide COc1ccc(CN2Cc3cc(Cl)c4c(Cl)c[nH]c4c3NS2(=O)=O)cn1 Degrader C16H14Cl2N4O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-1IMYT7 SCHEMBL25150462 6,7-Dichloro-3-(2-methoxyethyl)-1,3,4,9-tetrahydropyrrolo[3,2-h][2,1]benzothiazine 2,2-dioxide\; SCHEMBL25150462 COCCC1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C13H14Cl2N2O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-D3U308 SCHEMBL25150385 6,7-dichloro-3-(1-phenylethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25150385 CC(c1ccccc1)N1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C17H15Cl2N3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-HTUH5P SCHEMBL25149616 2-(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)ethanol\; SCHEMBL25149616 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1CCO Degrader C11H11Cl2N3O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-566I0N WO2023064058-A1_25 6,7-dichloro-3-(4,4,5,5,5-pentafluoropentyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1CCCC(F)(F)C(F)(F)F Degrader C14H12Cl2F5N3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-RBA709 SCHEMBL25150453 6,7-dichloro-3-(pyridin-3-ylmethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25150453 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1cccnc1 Degrader C15H12Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-N0J4OH SCHEMBL25150366 6,7-dichloro-3-[(2-chloropyridin-3-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25150366 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1cccnc1Cl Degrader C15H11Cl3N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-3R70FX SCHEMBL25150463 2-(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)-N-methylethanamine\; SCHEMBL25150463 CNCCN1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C12H14Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-0BGKMF SCHEMBL25150489 (3R)-6,7-dichloro-3-(2-methoxyethyl)-1,3,4,9-tetrahydropyrrolo[3,2-h][2,1]benzothiazine 2,2-dioxide\; SCHEMBL25150489 COCC[C@H]1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C13H14Cl2N2O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-PD1FYW SCHEMBL25150455 6,7-Dichloro-1,3,4,9-tetrahydro-[1,2,6]thiadiazino[4,3-g]indole 2,2-dioxide\; SCHEMBL25150455; 6,7-Dichloro-1,3,4,9-tetrahydro-[1,2,6]thiadiazino[4,3-g]indole 2,2-dioxide; 2923335-54-8 O=S1(=O)NCc2cc(Cl)c3c(Cl)c[nH]c3c2N1 Degrader C9H7Cl2N3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-DYDNZD SCHEMBL25150484 (3S)-6,7-dichloro-3-(2-methoxyethyl)-1,3,4,9-tetrahydropyrrolo[3,2-h][2,1]benzothiazine 2,2-dioxide\; SCHEMBL25150484 COCC[C@@H]1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C13H14Cl2N2O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-V3XY5Z SCHEMBL25150293 5,7-Dichloro-12lambda6-thia-3,8,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),2(6),4,7-tetraene 12,12-dioxide\; SCHEMBL25150293 O=S1(=O)NCc2nc(Cl)c3c(Cl)c[nH]c3c2N1 Degrader C8H6Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-XWXLO9 WO2023064058-A1_32 6,7-dichloro-3-(4,4,4-trifluorobutyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1CCCC(F)(F)F Degrader C13H12Cl2F3N3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-RDK8FL SCHEMBL25150388 6,7-dichloro-3-(pyrimidin-5-ylmethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25150388 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1cncnc1 Degrader C14H11Cl2N5O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-M69ZDJ SCHEMBL25150475 6,7-dichloro-3-(oxetan-3-ylmethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25150475 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1CC1COC1 Degrader C13H13Cl2N3O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-H7PMM5 SCHEMBL25150423 6,7-dichloro-3-[(3-chloropyridin-4-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25150423 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1ccncc1Cl Degrader C15H11Cl3N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-FFKKWK SCHEMBL25150368 6,7-dichloro-3-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25150368 Cc1nnc(CN2Cc3cc(Cl)c4c(Cl)c[nH]c4c3NS2(=O)=O)o1 Degrader C13H11Cl2N5O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-9A947A WO2023064058-A1_37 . Cn1cnc(CN2Cc3cc(CI)c4c(Cl)c[nH]c4c3NS2(=O)=O)n1 Degrader C14H14ClIN6O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-K4HN4N SCHEMBL25149399 6,7-dichloro-3-[(2-methyl-1,2,4-triazol-3-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25149399 Cn1ncnc1CN1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C13H12Cl2N6O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-CPYPUF SCHEMBL25149606 6,7-dichloro-3-(piperidin-4-ylmethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25149606 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1CC1CCNCC1 Degrader C15H18Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-CEWJ7T SCHEMBL25150450 7-chloro-3-cyclohexyl-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25150450 O=S1(=O)Nc2c(ccc3c(Cl)c[nH]c23)CN1C1CCCCC1 Degrader C15H18ClN3O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-7MPY5M WO2023064058-A1_40 N-[2-(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)ethyl]acetamide CC(=O)NCCN1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C13H14Cl2N4O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-TP170K SCHEMBL25149708 2-(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)-N,N-dimethylethanamine\; SCHEMBL25149708 CN(C)CCN1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C13H16Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-4250HR SCHEMBL25149565 6,7-dichloro-3-(pyridazin-3-ylmethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25149565 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1cccnn1 Degrader C14H11Cl2N5O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-U9OLCJ SCHEMBL25149402 6,7-dichloro-3-[(1-methylpyrazol-4-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25149402 Cn1cc(CN2Cc3cc(Cl)c4c(Cl)c[nH]c4c3NS2(=O)=O)cn1 Degrader C14H13Cl2N5O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-VHRDHW SCHEMBL25149754 6,7-dichloro-3-(oxan-4-ylmethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25149754 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1CC1CCOCC1 Degrader C15H17Cl2N3O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-IXFQSS SCHEMBL25149669 1-[4-[(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)methyl]piperidin-1-yl]ethanone\; SCHEMBL25149669 CC(=O)N1CCC(CN2Cc3cc(Cl)c4c(Cl)c[nH]c4c3NS2(=O)=O)CC1 Degrader C17H20Cl2N4O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-NOLTNF SCHEMBL25149433 2-[(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)methyl]benzonitrile\; SCHEMBL25149433 N#Cc1ccccc1CN1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C17H12Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-957PZG SCHEMBL25150292 1-[3-[(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)methyl]azetidin-1-yl]ethanone\; SCHEMBL25150292 CC(=O)N1CC(CN2Cc3cc(Cl)c4c(Cl)c[nH]c4c3NS2(=O)=O)C1 Degrader C15H16Cl2N4O3S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-HGMAWU SCHEMBL25149404 6,7-dichloro-3-[(6-methylpyridin-3-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25149404 Cc1ccc(CN2Cc3cc(Cl)c4c(Cl)c[nH]c4c3NS2(=O)=O)cn1 Degrader C16H14Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-XVTZPP SCHEMBL25149475 6,7-dichloro-3-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide\; SCHEMBL25149475 O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1ccc(C(F)(F)F)nc1 Degrader C16H11Cl2F3N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-Q9TNZL SCHEMBL25150451 6,7-Dichloro-1,3,4,9-tetrahydropyrrolo[3,2-h][2,1]benzothiazine 2,2-dioxide\; SCHEMBL25150451 O=S1(=O)CCc2cc(Cl)c3c(Cl)c[nH]c3c2N1 Degrader C10H8Cl2N2O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-K4RBZ2 WO2023064058-A1_50 4-[(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)methyl]benzonitrile N#Cc1ccc(CN2Cc3cc(Cl)c4c(Cl)c[nH]c4c3NS2(=O)=O)cc1 Degrader C17H12Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-Z7GXZ4 SCHEMBL25149406 3-[(6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl)methyl]benzonitrile\; SCHEMBL25149406 N#Cc1cccc(CN2Cc3cc(Cl)c4c(Cl)c[nH]c4c3NS2(=O)=O)c1 Degrader C17H12Cl2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-OIGTS8 WO2023064058-A1_52 6,7-dichloro-3-(pyrimidin-4-ylmethyl)-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1ccncn1 Degrader C14H11Cl2N5O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-05PCVN WO2023064058-A1_53 6,7-dichloro-3-[[6-(difluoromethyl)pyridin-3-yl]methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide O=S1(=O)Nc2c(cc(Cl)c3c(Cl)c[nH]c23)CN1Cc1ccc(C(F)F)nc1 Degrader C16H12Cl2F2N4O2S RBM39 Q14498 DCAF15 WO-2023064058-A1 TPD-KDQ1KD WO2023064152-A1_1 6,7-dichloro-3-[3-(2-methoxyethoxy)propyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide COCCOCCCN1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C15H19Cl2N3O4S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-E5BHJK WO2023064152-A1_11 tert-butyl 3-[[6,7-dichloro-8-(methylcarbamoyl)-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-3-yl]methyl]piperidine-1-carboxylate CNC(=O)c1[nH]c2c3c(cc(Cl)c2c1Cl)CN(CC1CCCN(C(=O)OC(C)(C)C)C1)S(=O)(=O)N3 Degrader C22H29Cl2N5O5S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-LDKT1Q WO2023064152-A1_12 3-[(1-acetylpiperidin-3-yl)methyl]-6,7-dichloro-N-methyl-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine-8-carboxamide CNC(=O)c1[nH]c2c3c(cc(Cl)c2c1Cl)CN(CC1CCCN(C(C)=O)C1)S(=O)(=O)N3 Degrader C19H23Cl2N5O4S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-HYLT6I WO2023064152-A1_13 methyl 6,7-dichloro-3-(3-methoxypropyl)-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine-8-carboxylate COCCCN1Cc2cc(Cl)c3c(Cl)c(C(=O)OC)[nH]c3c2NS1(=O)=O Degrader C15H17Cl2N3O5S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-FW39ZR WO2023064152-A1_14 ethyl 6,7-dichloro-3-(3-methoxypropyl)-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine-8-carboxylate CCOC(=O)c1[nH]c2c3c(cc(Cl)c2c1Cl)CN(CCCOC)S(=O)(=O)N3 Degrader C16H19Cl2N3O5S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-MBIFWA WO2023064152-A1_15 6,7-dichloro-3-(3-methoxypropyl)-N-methyl-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine-8-carboxamide CNC(=O)c1[nH]c2c3c(cc(Cl)c2c1Cl)CN(CCCOC)S(=O)(=O)N3 Degrader C15H18Cl2N4O4S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-L2LFHS WO2023064152-A1_16 6,7-dichloro-N-methyl-2,2-dioxo-3-[(2-oxo-1H-pyridin-4-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine-8-carboxamide CNC(=O)c1[nH]c2c3c(cc(Cl)c2c1Cl)CN(Cc1ccnc(O)c1)S(=O)(=O)N3 Degrader C17H15Cl2N5O4S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-G9G28D WO2023064152-A1_18 4-[6,7-dichloro-3-(3-methoxypropyl)-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-8-yl]butanoic acid COCCCN1Cc2cc(Cl)c3c(Cl)c(CCCC(=O)O)[nH]c3c2NS1(=O)=O Degrader C17H21Cl2N3O5S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-U7F6CJ WO2023064152-A1_19 4-[6,7-dichloro-3-(3-methoxypropyl)-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-8-yl]butanamide COCCCN1Cc2cc(Cl)c3c(Cl)c(CCCC(N)=O)[nH]c3c2NS1(=O)=O Degrader C17H22Cl2N4O4S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-XQJ9BH WO2023064152-A1_2 6,7-dichloro-3-[3-[2-(2-methoxyethoxy)ethoxy]propyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazine 2,2-dioxide COCCOCCOCCCN1Cc2cc(Cl)c3c(Cl)c[nH]c3c2NS1(=O)=O Degrader C17H23Cl2N3O5S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-8R35AW WO2023064152-A1_20 4-[3-[(1-acetylpiperidin-3-yl)methyl]-6,7-dichloro-2,2-dioxo-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-8-yl]butanamide CC(=O)N1CCCC(CN2Cc3cc(Cl)c4c(Cl)c(CCCC(N)=O)[nH]c4c3NS2(=O)=O)C1 Degrader C21H27Cl2N5O4S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-PFW4FA WO2023064152-A1_21 4-[6,7-dichloro-2,2-dioxo-3-[(2-oxo-1H-pyridin-4-yl)methyl]-4,9-dihydro-1H-pyrrolo[3,2-h][2,1,3]benzothiadiazin-8-yl]butanamide NC(=O)CCCc1[nH]c2c3c(cc(Cl)c2c1Cl)CN(Cc1ccnc(O)c1)S(=O)(=O)N3 Degrader C19H19Cl2N5O4S RBM39 Q14498 DCAF15 WO-2023064152-A1 TPD-EZV37J WO2023081224-A1_1 . COc1cccc(C(=O)NCc2cccc3c2CN(C2CCC(=O)N=NC2=O)C3=O)c1 Degrader C22H20N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-GUOPPU SPQGRSKDQIJOBF-UHFFFAOYSA-N N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-benzamide\; SCHEMBL1962104; SPQGRSKDQIJOBF-UHFFFAOYSA-N; N-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-benzamide; N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-benzamide O=C1CCC(N2Cc3c(CNC(=O)c4ccccc4)cccc3C2=O)C(=O)N1 Degrader C21H19N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-6R8XJM WO2023081224-A1_11 . Cc1ccc(C(=O)NCc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C22H21N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-MHZGNV WO2023081224-A1_12 . O=C1CCC(N2Cc3c(CNC(=O)c4cccc(C(F)(F)F)c4)cccc3C2=O)C(=O)N1 Degrader C22H18F3N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-USFLU5 NSC835957 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]methyl]-4-(trifluoromethyl)benzamide\; NSC835957; NSC-835957 O=C1CCC(N2Cc3c(CNC(=O)c4ccc(C(F)(F)F)cc4)cccc3C2=O)C(=O)N1 Degrader C22H18F3N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-BNX6T3 NBBHXJAALPXFGD-UHFFFAOYSA-N 3,4-dichloro-N-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-benzamide\; SCHEMBL1962089; NBBHXJAALPXFGD-UHFFFAOYSA-N; 3,4-dichloro-N-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-benzamide O=C1CCC(N2Cc3c(CNC(=O)c4ccc(Cl)c(Cl)c4)cccc3C2=O)C(=O)N1 Degrader C21H17Cl2N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-T31ZUP WO2023081224-A1_15 . O=C1CCC(N2Cc3c(CNC(=O)c4ccc(F)c(Cl)c4)cccc3C2=O)C(=O)N1 Degrader C21H17ClFN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-MZDD5P WO2023081224-A1_16 . O=C1CCC(N2Cc3c(CNC(=O)c4ccc(C(F)(F)F)c(F)c4)cccc3C2=O)C(=O)N1 Degrader C22H17F4N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-OBDLJ9 WO2023081224-A1_17 . O=C1CCC(N2Cc3c(CNC(=O)c4ccc(F)cc4Cl)cccc3C2=O)C(=O)N1 Degrader C21H17ClFN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-36YRCV WO2023081224-A1_18 . O=C1CCC(N2Cc3c(CNC(=O)c4ccc(Br)cc4)cccc3C2=O)C(=O)N1 Degrader C21H18BrN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-CSCL1U WO2023081224-A1_19 . O=C1CCC(N2Cc3c(CNC(=O)c4ccc(Cl)c(F)c4)cccc3C2=O)C(=O)N1 Degrader C21H17ClFN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-Q50N2Y WO2023081224-A1_2 . O=C1CCC(N2Cc3c(CNC(=O)c4ccco4)cccc3C2=O)C(=O)N=N1 Degrader C19H16N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-F2VJFT WO2023081224-A1_20 . O=C1CCC(N2Cc3c(CNC(=O)c4cccc(OC(F)(F)F)c4)cccc3C2=O)C(=O)N1 Degrader C22H18F3N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-496KYD WO2023081224-A1_21 . O=C1CCC(N2Cc3c(CNC(=O)c4ccc(Cl)c(C(F)(F)F)c4)cccc3C2=O)C(=O)N1 Degrader C22H17ClF3N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-06YIYX WO2023081224-A1_22 . O=C1CCC(N2Cc3c(CNC(=O)c4ccc(F)c(C(F)(F)F)c4)cccc3C2=O)C(=O)N1 Degrader C22H17F4N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-NUI2AX WO2023081224-A1_23 . O=C1CCC(N2Cc3c(CNC(=O)c4cccc(C(F)F)c4)cccc3C2=O)C(=O)N1 Degrader C22H19F2N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-EJW325 WO2023081224-A1_24 . O=C1CCC(N2Cc3c(CNC(=O)c4ccc(C(F)F)cc4)cccc3C2=O)C(=O)N1 Degrader C22H19F2N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-57K0OM YFZQFLPZSCFTFN-UHFFFAOYSA-N N-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-4-methoxy-benzamide\; SCHEMBL1962037; YFZQFLPZSCFTFN-UHFFFAOYSA-N; N-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-4-methoxy-benzamide COc1ccc(C(=O)NCc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C22H21N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-IQJU45 VCNABSDAEWPOOO-UHFFFAOYSA-N 3-cyano-N-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-benzamide\; SCHEMBL1963649; VCNABSDAEWPOOO-UHFFFAOYSA-N; 3-cyano-N-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-benzamide N#Cc1cccc(C(=O)NCc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)c1 Degrader C22H18N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-1G1UTL WO2023081224-A1_27 . O=C1CCC(N2Cc3c(CNC(=O)c4cccs4)cccc3C2=O)C(=O)N1 Degrader C19H17N3O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-TAUSV3 WO2023081224-A1_28 . O=C1CCC(N2Cc3c(CNC(=O)c4ccc(Cl)cc4Cl)cccc3C2=O)C(=O)N1 Degrader C21H17Cl2N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-P0IK1B WFSLTXJWUZXYOW-UHFFFAOYSA-N N-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-2-methoxy-benzamide\; SCHEMBL1961688; WFSLTXJWUZXYOW-UHFFFAOYSA-N; N-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-2-methoxy-benzamide; N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-2-methoxy-benzamide COc1ccccc1C(=O)NCc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O Degrader C22H21N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-G3XSNE WO2023081224-A1_3 . O=C1CCC(N2Cc3c(CNC(=O)c4cccc(Cl)c4)cccc3C2=O)C(=O)N=N1 Degrader C21H17ClN4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023081224-A1 TPD-860JFX WO2023096822-A1_1 . O=C(Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)NCc1ccccc1 Degrader C22H21N3O4 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-EIQXFM WO2023096822-A1_10 . O=C(Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)NCc1cccc(C(F)(F)F)c1 Degrader C23H20F3N3O4 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-LOLUZ4 NSC835962 2-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-N-(2-phenylethyl)acetamide\; NSC835962; NSC-835962 O=C(Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)NCCc1ccccc1 Degrader C23H23N3O4 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-3VXER5 NSC835963 2-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-N-(naphthalen-1-ylmethyl)acetamide\; NSC835963; NSC-835963 O=C(Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)NCc1cccc2ccccc12 Degrader C26H23N3O4 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-KWY9I0 WO2023096822-A1_13 . COc1ccc(NC(=O)Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C22H21N3O5 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-6QUG6P WO2023096822-A1_14 . O=C1CCC(N2Cc3cc(CC(=O)N4CCOCC4)ccc3C2=O)C(=O)N1 Degrader C19H21N3O5 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-9FGLUB WO2023096822-A1_15 . O=C1CCC(N2Cc3cc(CC(=O)N4CCCCC4)ccc3C2=O)C(=O)N1 Degrader C20H23N3O4 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-8GS4CW WO2023096822-A1_16 . O=C(Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)NCc1ccc(Cl)cc1 Degrader C22H20ClN3O4 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-XDR765 WO2023096822-A1_17 . O=C1CCC(N2Cc3cc(CC(=O)Nc4ccccc4)ccc3C2=O)C(=O)N1 Degrader C21H19N3O4 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-MLZB57 WO2023096822-A1_18 . Cc1ccccc1NC(=O)Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H21N3O4 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-TU1PTY WO2023096822-A1_19 . COc1cccc(NC(=O)Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1 Degrader C22H21N3O5 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-2SAJF8 WO2023096822-A1_2 . O=C1CCC(N2Cc3cc(CC(=O)NC4CCCCC4)ccc3C2=O)C(=O)N1 Degrader C21H25N3O4 GSPT1 P15170 CRBN WO-2023096822-A1 TPD-JT3A97 3-[6-(bromomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione SCHEMBL24991548 O=C1CCC(N2Cc3cc(CBr)ccc3C2=O)C(=O)N1 Degrader C14H13BrN2O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023104155-A1 TPD-61A78Y 3-[7-bromo-5-(bromomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione SCHEMBL25272485 O=C1CCC(N2Cc3c(Br)cc(CBr)cc3C2=O)C(=O)N1 Degrader C14H12Br2N2O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023104155-A1 TPD-O8Z2GY 3-(5-(Hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione 2761170-98-1; SCHEMBL24991511; MFCD35084250; SY388026; DB-378488; 3-(5-(Hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-[5-(Hydroxymethyl)-1-oxo-2-isoindolinyl]piperidine-2,6-dione; 3-[1,3-Dihydro-5-(hydroxymethyl)-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione O=C1CCC(N2Cc3cc(CO)ccc3C2=O)C(=O)N1 Degrader C14H14N2O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023104155-A1 TPD-DJRPSH SCHEMBL25764831 4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]amino]-2-oxoethyl]-N-(naphthalen-1-ylmethyl)piperidine-1-carboxamide\; SCHEMBL25764831 O=C1CCC(N2Cc3cc(NC(=O)CC4CCN(C(=O)NCc5cccc6ccccc56)CC4)ccc3C2=O)C(=O)N1 Degrader C32H33N5O5 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-HV91WO SCHEMBL25765004 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-[1-[2-(2-naphthalen-1-ylethylamino)-2-oxoethyl]piperidin-4-yl]acetamide\; SCHEMBL25765004 O=C(CN1CCC(CC(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1)NCCc1cccc2ccccc12 Degrader C34H37N5O5 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-OLDKRF SCHEMBL25767386 methyl 5-(3-chlorophenyl)-2-[4-[[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]methyl]piperidin-1-yl]pyridine-3-carboxylate\; SCHEMBL25767386 COC(=O)c1cc(-c2cccc(Cl)c2)cnc1N1CCC(CNCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C33H34ClN5O5 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-XZEDPN SCHEMBL25768323 3-[6-[[[1-[5-(3-chlorophenyl)-4-fluoropyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25768323 O=C1CCC(N2Cc3cc(CNCC4CCN(c5cc(F)c(-c6cccc(Cl)c6)cn5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31ClFN5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-72QHQO SCHEMBL25768383 3-[6-[[[1-[5-(3-chlorophenyl)pyrazin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25768383 O=C1CCC(N2Cc3cc(CNCC4CCN(c5cnc(-c6cccc(Cl)c6)cn5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H31ClN6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-TO3K5K SCHEMBL25767393 5-(3-chlorophenyl)-2-[4-[[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]methyl]piperidin-1-yl]benzonitrile\; SCHEMBL25767393 N#Cc1cc(-c2cccc(Cl)c2)ccc1N1CCC(CNCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C33H32ClN5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-8F23UE SCHEMBL25765015 3-[6-[[[1-[4-(3-chlorophenyl)-2-(trifluoromethyl)phenyl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765015 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ccc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C33H32ClF3N4O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-K41LT0 SCHEMBL25765019 3-[6-[[1-[1-[5-(3-chlorophenyl)-3-fluoropyridin-2-yl]piperidin-4-yl]ethylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765019 CC(NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCN(c2ncc(-c3cccc(Cl)c3)cc2F)CC1 Degrader C32H33ClFN5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-OPGSPE SCHEMBL25765175 3-[6-[[[1-(3-fluoro-5-pyridin-2-ylpyridin-2-yl)piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765175 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-c6ccccn6)cc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C30H31FN6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-78XB82 SCHEMBL25765180 3-[6-[[[1-[3-fluoro-5-(2-fluorophenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765180 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-c6ccccc6F)cc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31F2N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-TLQIPV SCHEMBL25765183 3-[6-[[[1-[3-fluoro-5-(3-fluorophenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765183 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(F)c6)cc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31F2N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-V506HA SCHEMBL25767407 3-[6-[[[1-[3-fluoro-5-(4-fluorophenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25767407 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-c6ccc(F)cc6)cc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31F2N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-O1N95T SCHEMBL25765007 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-[1-(2-pyrido[2,3-b]indol-9-ylacetyl)piperidin-4-yl]acetamide\; SCHEMBL25765007 O=C1CCC(N2Cc3cc(NC(=O)CC4CCN(C(=O)Cn5c6ccccc6c6cccnc65)CC4)ccc3C2=O)C(=O)N1 Degrader C33H32N6O5 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-BIFW43 SCHEMBL25765193 3-[6-[[[1-[3-fluoro-5-[3-(trifluoromethyl)phenyl]pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765193 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(C(F)(F)F)c6)cc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C32H31F4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-MTFA7F SCHEMBL25765196 3-[6-[4-[[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]methyl]piperidin-1-yl]-5-fluoropyridin-3-yl]benzonitrile\; SCHEMBL25765196 N#Cc1cccc(-c2cnc(N3CCC(CNCc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c(F)c2)c1 Degrader C32H31FN6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-50N9Y9 SCHEMBL25767432 3-[6-[[[1-[3-fluoro-5-(3-methoxyphenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25767432 COc1cccc(-c2cnc(N3CCC(CNCc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c(F)c2)c1 Degrader C32H34FN5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-XHV4ME SCHEMBL25767441 3-[6-[[[1-[5-(3-chloro-5-methoxyphenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25767441 COc1cc(Cl)cc(-c2cnc(N3CCC(CNCc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c(C(F)(F)F)c2)c1 Degrader C33H33ClF3N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-PZWJZ5 SCHEMBL25767457 3-[6-[[[1-[5-(3-chloro-5-methylphenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25767457 Cc1cc(Cl)cc(-c2cnc(N3CCC(CNCc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c(C(F)(F)F)c2)c1 Degrader C33H33ClF3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-18UOOS SCHEMBL25765349 3-[6-[[[1-[5-(3-chloro-5-fluorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765349 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-c6cc(F)cc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C32H30ClF4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-4BYJ3R WO2023116835-A1_A116 . O=C1CCC(N2C(=O)c3ccc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)cc3C2=O)C(=O)N1 Degrader C32H29ClF3N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-90PDO9 WO2023116835-A1_A117 . O=C(CC1CCN(c2ncc(-c3cccc4ccccc34)cn2)CC1)Nc1ccc2c(c1)CN(C1CCC(=O)N(COP(=O)(O)O)C1=O)C2=O Degrader C35H35N6O8P GSPT1 P15170 CRBN WO-2023116835-A1 TPD-ANRQGV SCHEMBL25765354 3-[6-[[[1-[5-(3-chlorophenyl)-3-(difluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765354 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C32H32ClF2N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-1RXBTJ SCHEMBL25765360 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-4-fluoro-1-[3-fluoro-5-(3-methoxyphenyl)pyridin-2-yl]piperidine-4-carboxamide\; SCHEMBL25765360 COc1cccc(-c2cnc(N3CCC(F)(C(=O)NCc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c(F)c2)c1 Degrader C32H31F2N5O5 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-QFBW9M SCHEMBL25765008 2-(2,6-dioxopiperidin-3-yl)-N-[[1-(4-naphthalen-1-ylpyrimidin-2-yl)piperidin-4-yl]methyl]-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL25765008 O=C1CCC(N2Cc3cc(C(=O)NCC4CCN(c5nccc(-c6cccc7ccccc67)n5)CC4)ccc3C2=O)C(=O)N1 Degrader C34H32N6O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-OOA6LP SCHEMBL25765363 3-[6-[[[4-fluoro-1-[3-fluoro-5-(3-methoxyphenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765363 COc1cccc(-c2cnc(N3CCC(F)(CNCc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c(F)c2)c1 Degrader C32H33F2N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-PL6CGD SCHEMBL25765367 3-[6-[[[4-fluoro-1-[5-(3-methoxyphenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765367 COc1cccc(-c2cnc(N3CCC(F)(CNCc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c(C(F)(F)F)c2)c1 Degrader C33H33F4N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-PJONYU SCHEMBL25765460 3-[6-[[[4-fluoro-1-[3-fluoro-5-(3-fluorophenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765460 O=C1CCC(N2Cc3cc(CNCC4(F)CCN(c5ncc(-c6cccc(F)c6)cc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H30F3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-Z0VXPW SCHEMBL25765466 (3S)-3-[6-[[[1-[5-(3-methylphenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765466 Cc1cccc(-c2cnc(N3CCC(CNCc4ccc5c(c4)CN([C@H]4CCC(=O)NC4=O)C5=O)CC3)c(C(F)(F)F)c2)c1 Degrader C33H34F3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-IF55D2 SCHEMBL25765472 (3R)-3-[6-[[[1-[5-(3-methylphenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765472 Cc1cccc(-c2cnc(N3CCC(CNCc4ccc5c(c4)CN([C@@H]4CCC(=O)NC4=O)C5=O)CC3)c(C(F)(F)F)c2)c1 Degrader C33H34F3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-AKL86P SCHEMBL25765474 (3S)-3-[6-[[[1-[3-fluoro-5-(3-fluorophenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765474 O=C1CC[C@H](N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(F)c6)cc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31F2N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-3MGUBJ SCHEMBL25765476 (3R)-3-[6-[[[1-[3-fluoro-5-(3-fluorophenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765476 O=C1CC[C@@H](N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(F)c6)cc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31F2N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-QYWP2U SCHEMBL25765480 (3S)-3-[6-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]-4-fluoropiperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765480 O=C1CC[C@H](N2Cc3cc(CNCC4(F)CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C32H30ClF4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-LTRQE9 SCHEMBL25765481 (3R)-3-[6-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]-4-fluoropiperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765481 O=C1CC[C@@H](N2Cc3cc(CNCC4(F)CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C32H30ClF4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-0H8Z02 SCHEMBL25765484 3-[6-[[[1-[5-carbazol-9-yl-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765484 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-n6c7ccccc7c7ccccc76)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C38H35F3N6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-3MT91G SCHEMBL25765010 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-[1-(4-naphthalen-1-ylpyrimidin-2-yl)piperidin-4-yl]acetamide\; SCHEMBL25765010 O=C1CCC(N2Cc3cc(NC(=O)CC4CCN(c5nccc(-c6cccc7ccccc67)n5)CC4)ccc3C2=O)C(=O)N1 Degrader C34H32N6O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-JP2NKK SCHEMBL25765566 4-[[4-(3-chloro-4-methylphenyl)piperazin-1-yl]methyl]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]benzamide\; SCHEMBL25765566 Cc1ccc(N2CCN(Cc3ccc(C(=O)NCc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)cc3)CC2)cc1Cl Degrader C33H34ClN5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-CVHGT2 SCHEMBL25765569 3-[6-[2-[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]ethylamino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765569 O=C1CCC(N2Cc3cc(NCCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C32H31ClF3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-YT5EVZ SCHEMBL25765571 3-[6-[2-[1-[5-(3-methoxyphenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]ethylamino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765571 COc1cccc(-c2cnc(N3CCC(CCNc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c(C(F)(F)F)c2)c1 Degrader C33H34F3N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-CQM5DD SCHEMBL25765573 3-[6-[2-[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765573 O=C1CCC(N2Cc3cc(OCCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C32H30ClF3N4O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-IXMUVW SCHEMBL25765576 3-[6-[3-[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]propyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765576 O=C1CCC(N2Cc3cc(CCCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C33H32ClF3N4O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-KRFEE1 SCHEMBL25765577 3-[6-[3-[4-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765577 O=C1CCC(N2Cc3cc(CCCN4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C32H31ClF3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-YC26QY SCHEMBL25765579 [2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl 4-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxylate\; SCHEMBL25765579 O=C1CCC(N2Cc3cc(COC(=O)N4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H27ClF3N5O5 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-EKSCES SCHEMBL25765582 4-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]piperazine-1-carboxamide\; SCHEMBL25765582 O=C1CCC(N2Cc3cc(CNC(=O)N4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H28ClF3N6O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-RU90R2 SCHEMBL25765662 6-[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methyl]-2-(2,6-dioxopiperidin-3-yl)-5,7-dihydropyrrolo[3,4-f]isoindole-1,3-dione\; SCHEMBL25765662 O=C1CCC(N2C(=O)c3cc4c(cc3C2=O)CN(CC2CCN(c3ncc(-c5cccc(Cl)c5)cc3C(F)(F)F)CC2)C4)C(=O)N1 Degrader C33H29ClF3N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-4964DK SCHEMBL25765664 3-[6-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765664 O=C1CCC(N2Cc3c(ccc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)c3F)C2=O)C(=O)N1 Degrader C32H30ClF4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-RQ2PB8 SCHEMBL25765012 2-(2,6-dioxopiperidin-3-yl)-N-[[1-(6-naphthalen-1-ylpyridin-2-yl)piperidin-4-yl]methyl]-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL25765012 O=C1CCC(N2Cc3cc(C(=O)NCC4CCN(c5cccc(-c6cccc7ccccc67)n5)CC4)ccc3C2=O)C(=O)N1 Degrader C35H33N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-JNPSIC SCHEMBL25765667 3-[6-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765667 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C32H30ClF4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-D4PBQ0 SCHEMBL25765668 3-[2-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-5-oxo-7H-pyrrolo[3,4-b]pyridin-6-yl]piperidine-2,6-dione\; SCHEMBL25765668 O=C1CCC(N2Cc3nc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H30ClF3N6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-KEGWBI SCHEMBL25765671 3-[6-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-pyrrolo[3,4-c]pyridin-2-yl]piperidine-2,6-dione\; SCHEMBL25765671 O=C1CCC(N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ncc3C2=O)C(=O)N1 Degrader C31H30ClF3N6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-I9T90P SCHEMBL25765675 3-[3-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-6-oxo-4H-thieno[3,4-c]pyrrol-5-yl]piperidine-2,6-dione\; SCHEMBL25765675 O=C1CCC(N2Cc3c(csc3CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)C2=O)C(=O)N1 Degrader C30H29ClF3N5O3S GSPT1 P15170 CRBN WO-2023116835-A1 TPD-KW0FGI SCHEMBL25765676 3-[3-[[[1-[5-(3-methoxyphenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-6-oxo-4H-thieno[3,4-c]pyrrol-5-yl]piperidine-2,6-dione\; SCHEMBL25765676 COc1cccc(-c2cnc(N3CCC(CNCc4scc5c4CN(C4CCC(=O)NC4=O)C5=O)CC3)c(C(F)(F)F)c2)c1 Degrader C31H32F3N5O4S GSPT1 P15170 CRBN WO-2023116835-A1 TPD-ASHKG0 SCHEMBL25765683 3-[5-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25765683 O=C1CCC(N2Cc3ccc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)cc3C2)C(=O)N1 Degrader C32H33ClF3N5O2 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-5ED32X SCHEMBL25765764 3-[7-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-[1,2,4]triazolo[4,3-a]pyridin-2-yl]piperidine-2,6-dione\; SCHEMBL25765764 O=C1CCC(n2nc3cc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccn3c2=O)C(=O)N1 Degrader C30H29ClF3N7O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-6UNHMG SCHEMBL25765767 3-[7-[[[1-[3-Fluoro-5-(3-fluorophenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-[1,2,4]triazolo[4,3-a]pyridin-2-yl]piperidine-2,6-dione\; SCHEMBL25765767 O=C1CCC(n2nc3cc(CNCC4CCN(c5ncc(-c6cccc(F)c6)cc5F)CC4)ccn3c2=O)C(=O)N1 Degrader C29H29F2N7O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-ZSDNX7 SCHEMBL25765769 3-[6-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]imidazo[1,2-a]pyridin-2-yl]piperidine-2,6-dione\; SCHEMBL25765769 O=C1CCC(c2cn3cc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3n2)C(=O)N1 Degrader C31H30ClF3N6O2 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-ENFA99 SCHEMBL25765771 3-[6-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-1-benzofuran-3-yl]piperidine-2,6-dione\; SCHEMBL25765771 O=C1CCC(c2coc3cc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc23)C(=O)N1 Degrader C32H30ClF3N4O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-I0NP5M WO2023116835-A1_A15 . O=C1CCC(N2Cc3cc(NC(=O)CC4CCN(c5cccc(C6=C7C=CC=CC7CC=C6)n5)CC4)ccc3C2=O)C(=O)N1 Degrader C35H35N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-IAREEK SCHEMBL25767914 3-[5-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-1-benzofuran-3-yl]piperidine-2,6-dione\; SCHEMBL25767914 O=C1CCC(c2coc3ccc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)cc23)C(=O)N1 Degrader C32H30ClF3N4O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-LRZEG9 SCHEMBL25765776 3-[6-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25765776 Cc1nc2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)cc2c(=O)n1C1CCC(=O)NC1=O Degrader C33H32ClF3N6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-129D4P SCHEMBL25765778 3-[7-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25765778 Cc1nc2cc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)ccc2c(=O)n1C1CCC(=O)NC1=O Degrader C33H32ClF3N6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-L6BZQ7 SCHEMBL25765781 3-[7-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-2-cyclopropyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25765781 O=C1CCC(n2c(C3CC3)nc3cc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3c2=O)C(=O)N1 Degrader C35H34ClF3N6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-JHKB2K SCHEMBL25765861 3-[6-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-4-oxo-1,2,3-benzotriazin-3-yl]piperidine-2,6-dione\; SCHEMBL25765861 O=C1CCC(n2nnc3ccc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)cc3c2=O)C(=O)N1 Degrader C31H29ClF3N7O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-UEZBY5 SCHEMBL25765862 4-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-N-(2,6-dioxopiperidin-3-yl)benzamide\; SCHEMBL25765862 O=C1CCC(NC(=O)c2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)cc2)C(=O)N1 Degrader C31H31ClF3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-1L6DFP SCHEMBL25768002 5-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-N-(2,6-dioxopiperidin-3-yl)pyridine-2-carboxamide\; SCHEMBL25768002 O=C1CCC(NC(=O)c2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)cn2)C(=O)N1 Degrader C30H30ClF3N6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-4UJLS3 SCHEMBL25765867 6-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-N-(2,6-dioxopiperidin-3-yl)pyridine-3-carboxamide\; SCHEMBL25765867 O=C1CCC(NC(=O)c2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)nc2)C(=O)N1 Degrader C30H30ClF3N6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-6OCU4Y SCHEMBL25765871 4-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-N-(2,6-dioxopiperidin-3-yl)-2-fluorobenzamide\; SCHEMBL25765871 O=C1CCC(NC(=O)c2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)cc2F)C(=O)N1 Degrader C31H30ClF4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-0G7ANE SCHEMBL25765874 4-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-N-(2,6-dioxopiperidin-3-yl)-3-fluorobenzamide\; SCHEMBL25765874 O=C1CCC(NC(=O)c2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)c(F)c2)C(=O)N1 Degrader C31H30ClF4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-T84QOK SCHEMBL25765016 2-(2,6-dioxopiperidin-3-yl)-N-[[1-(4-naphthalen-1-ylpyridin-2-yl)piperidin-4-yl]methyl]-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL25765016 O=C1CCC(N2Cc3cc(C(=O)NCC4CCN(c5cc(-c6cccc7ccccc67)ccn5)CC4)ccc3C2=O)C(=O)N1 Degrader C35H33N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-8L0K32 SCHEMBL25765877 3-bromo-4-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-N-(2,6-dioxopiperidin-3-yl)benzamide\; SCHEMBL25765877 O=C1CCC(NC(=O)c2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)c(Br)c2)C(=O)N1 Degrader C31H30BrClF3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-LIDZS2 SCHEMBL25765882 4-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-N-(2,6-dioxopiperidin-3-yl)-2-methoxybenzamide\; SCHEMBL25765882 COc1cc(CNCC2CCN(c3ncc(-c4cccc(Cl)c4)cc3C(F)(F)F)CC2)ccc1C(=O)NC1CCC(=O)NC1=O Degrader C32H33ClF3N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-YES7GP SCHEMBL25765948 4-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-2-cyano-N-(2,6-dioxopiperidin-3-yl)benzamide\; SCHEMBL25765948 N#Cc1cc(CNCC2CCN(c3ncc(-c4cccc(Cl)c4)cc3C(F)(F)F)CC2)ccc1C(=O)NC1CCC(=O)NC1=O Degrader C32H30ClF3N6O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-OND5UL WO2023116835-A1_A163 . C=C1NC(=O)CCC1N(C)C(=O)c1ccc(CNCC2CCN(c3ncc(-c4cccc(Cl)c4)cc3C(F)(F)F)CC2)cc1 Degrader C33H35ClF3N5O2 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-V53FA2 SCHEMBL25768076 4-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-N-(2,6-dioxopiperidin-3-yl)benzenesulfonamide\; SCHEMBL25768076 O=C1CCC(NS(=O)(=O)c2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)cc2)C(=O)N1 Degrader C30H31ClF3N5O4S GSPT1 P15170 CRBN WO-2023116835-A1 TPD-MQ2AA2 SCHEMBL25765957 3-[[4-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]phenyl]methylamino]piperidine-2,6-dione\; SCHEMBL25765957 O=C1CCC(NCc2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)cc2)C(=O)N1 Degrader C31H33ClF3N5O2 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-T7NYEW SCHEMBL25765960 1-N-[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methyl]-4-N-(2,6-dioxopiperidin-3-yl)benzene-1,4-dicarboxamide\; SCHEMBL25765960 O=C1CCC(NC(=O)c2ccc(C(=O)NCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)cc2)C(=O)N1 Degrader C31H29ClF3N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-9D73EG SCHEMBL25765961 2-[4-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]phenyl]-N-(2,6-dioxopiperidin-3-yl)acetamide\; SCHEMBL25765961 O=C1CCC(NC(=O)Cc2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)cc2)C(=O)N1 Degrader C32H33ClF3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-WXAYEH WO2023116835-A1_A168 . O=C1CCC(n2cc(-c3ccc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)cc3)nn2)C(=O)N1 Degrader C32H31ClF3N7O2 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-XV9DE6 SCHEMBL25765967 (3S)-3-[6-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]pyrrolidine-2,5-dione\; SCHEMBL25765967 O=C1C[C@H](N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H29ClF3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-2AQB7W SCHEMBL25765173 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-[1-(4-naphthalen-1-ylpyridin-2-yl)piperidin-4-yl]acetamide\; SCHEMBL25765173 O=C1CCC(N2Cc3cc(NC(=O)CC4CCN(c5cc(-c6cccc7ccccc67)ccn5)CC4)ccc3C2=O)C(=O)N1 Degrader C35H33N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-RJQAL9 SCHEMBL25766013 (3S)-3-[6-[[[1-[3-fluoro-5-(3-fluorophenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]pyrrolidine-2,5-dione\; SCHEMBL25766013 O=C1C[C@H](N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(F)c6)cc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C30H29F2N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-PRLF17 SCHEMBL25766014 (3R)-3-[6-[[[1-[5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]pyrrolidine-2,5-dione\; SCHEMBL25766014 O=C1C[C@@H](N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(Cl)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H29ClF3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-4E2NZ9 SCHEMBL25766016 (3S)-3-[6-[[[1-[5-(3-fluorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]pyrrolidine-2,5-dione\; SCHEMBL25766016 O=C1C[C@H](N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(F)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H29F4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-AUYIT0 SCHEMBL25766017 (3R)-3-[6-[[[1-[5-(3-fluorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-3-oxo-1H-isoindol-2-yl]pyrrolidine-2,5-dione\; SCHEMBL25766017 O=C1C[C@@H](N2Cc3cc(CNCC4CCN(c5ncc(-c6cccc(F)c6)cc5C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C31H29F4N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-GBHY9Q SCHEMBL25766018 3-[6-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione\; SCHEMBL25766018 O=C1CCC(N2C(=O)c3cccc4c(CNCC5CCN(c6ncc(-c7cccc(Cl)c7)cc6C(F)(F)F)CC5)ccc2c34)C(=O)N1 Degrader C35H31ClF3N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-ZCJZV0 SCHEMBL25766020 3-[6-[[[1-[3-Fluoro-5-(3-fluorophenyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione\; SCHEMBL25766020 O=C1CCC(N2C(=O)c3cccc4c(CNCC5CCN(c6ncc(-c7cccc(F)c7)cc6F)CC5)ccc2c34)C(=O)N1 Degrader C34H31F2N5O3 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-RPIZ3D SCHEMBL25766022 1-[5-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-1-methylindazol-3-yl]-1,3-diazinane-2,4-dione\; SCHEMBL25766022 Cn1nc(N2CCC(=O)NC2=O)c2cc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)ccc21 Degrader C31H31ClF3N7O2 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-ZSHJJU SCHEMBL25766027 1-[6-[[[1-[5-(3-Chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methylamino]methyl]-1-methylindazol-3-yl]-1,3-diazinane-2,4-dione\; SCHEMBL25766027 Cn1nc(N2CCC(=O)NC2=O)c2ccc(CNCC3CCN(c4ncc(-c5cccc(Cl)c5)cc4C(F)(F)F)CC3)cc21 Degrader C31H31ClF3N7O2 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-6BW576 SCHEMBL25765179 2-(2,6-dioxopiperidin-3-yl)-N-[[1-(5-naphthalen-1-ylpyridin-3-yl)piperidin-4-yl]methyl]-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL25765179 O=C1CCC(N2Cc3cc(C(=O)NCC4CCN(c5cncc(-c6cccc7ccccc67)c5)CC4)ccc3C2=O)C(=O)N1 Degrader C35H33N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-N9O1DG SCHEMBL25765182 2-(2,6-dioxopiperidin-3-yl)-N-[[1-(2-naphthalen-1-ylpyridin-4-yl)piperidin-4-yl]methyl]-1-oxo-3H-isoindole-5-carboxamide\; SCHEMBL25765182 O=C1CCC(N2Cc3cc(C(=O)NCC4CCN(c5ccnc(-c6cccc7ccccc67)c5)CC4)ccc3C2=O)C(=O)N1 Degrader C35H33N5O4 GSPT1 P15170 CRBN WO-2023116835-A1 TPD-ARJ1M8 (Rac)-Cemsidomide (Rac)-Cemsidomide; 2504233-68-3; (Rac)-CFT7455; orb1687018; SCHEMBL22533014; SCHEMBL25982437; SCHEMBL29378250; HY-144841A; MS-28679; CS-0529719; 3-(6-(4-(Morpholinomethyl)benzyl)-2-oxobenzo[cd]indol-1(2H)-yl)piperidine-2,6-dione; 3-[6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione O=C1CCC(N2C(=O)/C3=C/C=C\C4=C(CC5=CC=C(CN6CCOCC6)C=C5)C=CC2=C43)C(=O)N1 Degrader C28H27N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023154417-A1 TPD-5VY177 SCHEMBL25391364 3-[6-[[(1R,2S)-2-aminocyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391364 N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C20H25N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-U43KVO SCHEMBL25392107 3-[6-[[(1R,2S)-2-[(4,4-difluorocyclohexyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392107 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCC4CCC(F)(F)CC4)ccc3C2=O)C(=O)N1 Degrader C27H35F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-CXA3NY SCHEMBL25393811 3-[6-[[(1R,2S)-2-[(2,2-dimethylspiro[3.3]heptan-6-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393811 CC1(C)CC2(CC(N[C@H]3CCCC[C@@H]3Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)C1 Degrader C29H39N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-9Y8KQ8 SCHEMBL25394851 3-[6-[[(1R,2S)-2-[(2,2-difluorospiro[3.3]heptan-6-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394851 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CC5(C4)CC(F)(F)C5)ccc3C2=O)C(=O)N1 Degrader C27H33F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-D0YEI5 SCHEMBL25392722 3-[6-[[(1R,2S)-2-(1-cyclopropylethylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392722 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CC1 Degrader C25H33N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-SG3F60 SCHEMBL25394442 3-[3-oxo-6-[[(1R,2S)-2-(3,3,3-trifluoropropylamino)cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394442 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCCC(F)(F)F)ccc3C2=O)C(=O)N1 Degrader C23H28F3N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-UXHHZM SCHEMBL25392213 3-[6-[[(1R,2S)-2-[[(2S)-2-fluorocyclohexyl]amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392213 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCCC[C@@H]4F)ccc3C2=O)C(=O)N1 Degrader C26H34FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-AGOTG5 SCHEMBL25391631 3-[6-[[(1R,2S)-2-[[(2R)-2-fluorocyclohexyl]amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391631 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCCC[C@H]4F)ccc3C2=O)C(=O)N1 Degrader C26H34FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-Z6QY0Q SCHEMBL25395655 3-[6-[[(1R,2S)-2-[(1-acetylpiperidin-4-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25395655 CC(=O)N1CCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C27H36N4O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-2XLBFI SCHEMBL25393089 3-[6-[[(1R,2S)-2-(benzylamino)cyclohexyl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393089 O=C1CCC(N2Cc3c(ccc(C[C@H]4CCCC[C@@H]4NCc4ccccc4)c3F)C2=O)C(=O)N1 Degrader C27H30FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-TZW7FL SCHEMBL25393234 3-[6-[[(1R,2S)-2-[(2,2-dimethyloxan-4-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393234 CC1(C)CC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CCO1 Degrader C27H37N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-VRXHQ1 WO2023178181-A1_119 . CC1(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CCC(F)(F)CC1 Degrader C27H35F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-SFWEZR SCHEMBL25390609 3-[6-[[(1R,2S)-2-[(4-methylsulfonylphenyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25390609 CS(=O)(=O)c1ccc(CN[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C28H33N3O5S IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-Q4JKVL WO2023178181-A1_120 . Cc1c(C)c(C)c(C(C)N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c(C)c1C Degrader C33H43N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-7ED7GK SCHEMBL25392891 3-[3-oxo-6-[[(1R,2S)-2-[[4-(trifluoromethyl)cyclohexyl]amino]cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392891; SCHEMBL26250049; SCHEMBL26250080 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC(C(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C27H34F3N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-1PAC0U SCHEMBL25394502 3-[6-[[(1R,2S)-2-[(4,4-difluorocyclohexyl)-methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394502 CN(C1CCC(F)(F)CC1)[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C27H35F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-3NZEOM SCHEMBL25392014 3-[6-[[(1R,2S)-2-[(4,4-difluorocyclohexyl)-methylamino]cyclohexyl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392014 CN(C1CCC(F)(F)CC1)[C@H]1CCCC[C@@H]1Cc1ccc2c(c1F)CN(C1CCC(=O)NC1=O)C2=O Degrader C27H34F3N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-NOXTGU SCHEMBL25393915 3-[6-[[(1R,2S)-2-(7-oxaspiro[3.5]nonan-2-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393915 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CC5(CCOCC5)C4)ccc3C2=O)C(=O)N1 Degrader C28H37N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-2TVRDO SCHEMBL25392365 3-[6-[[(3R,4S)-3-[(4,4-difluorocyclohexyl)amino]oxan-4-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392365 O=C1CCC(N2Cc3cc(C[C@H]4CCOC[C@@H]4NC4CCC(F)(F)CC4)ccc3C2=O)C(=O)N1 Degrader C25H31F2N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-GWWWIX SCHEMBL25394700 3-[6-[[(1R,2S)-2-(1-fluoropropan-2-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394700 CC(CF)N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H30FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-W11FYV SCHEMBL25393692 3-[6-[[(1R,2S)-2-(butylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393692 CCCCN[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H33N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-ZT8W8G SCHEMBL25432681 3-[6-[[(1R,2S)-2-(3-methylbutylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25432681 CC(C)CCN[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-5R3IOA SCHEMBL25394723 3-[6-[[(1R,2S)-2-[(3,5-dichlorophenyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394723 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCc4cc(Cl)cc(Cl)c4)ccc3C2=O)C(=O)N1 Degrader C27H29Cl2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-7Y3KZ6 SCHEMBL25394594 3-[6-[[(1R,2S)-2-(1,1-difluoropropan-2-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394594 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C(F)F Degrader C23H29F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-CU2S2C SCHEMBL25391725 3-[6-[[(1R,2S)-2-(2,3-dihydro-1H-inden-1-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391725 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCc5ccccc54)ccc3C2=O)C(=O)N1 Degrader C29H33N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-1JJKGC SCHEMBL25392291 3-[6-[[(1R,2S)-2-(3-bicyclo[3.2.0]heptanylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392291 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CC5CCC5C4)ccc3C2=O)C(=O)N1 Degrader C27H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-6DXW1W SCHEMBL25392184 4-[[(1S,2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]cyclohexyl]amino]-2,2-dimethylbutanenitrile\; SCHEMBL25392184 CC(C)(C#N)CCN[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C26H34N4O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-LJB12T SCHEMBL25391889 3-[6-[[(1R,2S)-2-[(3-methoxy-3-methylbutyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391889 COC(C)(C)CCN[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C26H37N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-5Q6YC9 SCHEMBL25393333 3-[6-[[(1R,2S)-2-(4,4-difluorobutylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393333 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCCCC(F)F)ccc3C2=O)C(=O)N1 Degrader C24H31F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-V671U0 SCHEMBL25392958 3-[6-[[(1R,2S)-2-[1-(3,3-difluorocyclobutyl)ethylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392958 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CC(F)(F)C1 Degrader C26H33F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-WEL3KF SCHEMBL25392433 3-[6-[[(1R,2S)-2-[1-(1-bicyclo[1.1.1]pentanyl)ethylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392433 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C12CC(C1)C2 Degrader C27H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-LR42AC SCHEMBL25390488 3-[6-[[(1R,2S)-2-[(4-methoxyphenyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25390488 COc1ccc(CN[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C28H33N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-K1FGRR SCHEMBL25390900 3-[6-[[(1R,2S)-2-[(6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25390900 CC1(C)C2CC(N[C@H]3CCCC[C@@H]3Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC21 Degrader C28H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-DWWUB6 SCHEMBL25393521 3-[6-[[(1R,2S)-2-(1,2,3,3a,4,5,6,6a-octahydropentalen-2-ylamino)cyclohexyl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393521 O=C1CCC(N2Cc3c(ccc(C[C@H]4CCCC[C@@H]4NC4CC5CCCC5C4)c3F)C2=O)C(=O)N1 Degrader C28H36FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-510GL4 SCHEMBL25391008 3-[6-[[(1R,2S)-2-[(7,7-difluorospiro[3.5]nonan-2-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391008 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CC5(CCC(F)(F)CC5)C4)ccc3C2=O)C(=O)N1 Degrader C29H37F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-B2UPMA SCHEMBL25393586 3-[6-[[(1R,2S)-2-(3,4-dihydro-2H-chromen-3-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393586 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4COc5ccccc5C4)ccc3C2=O)C(=O)N1 Degrader C29H33N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-KYC395 SCHEMBL25391646 3-[3-oxo-6-[[(1R,2S)-2-[(3,3,5,5-tetramethylcyclohexyl)amino]cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391646 CC1(C)CC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC(C)(C)C1 Degrader C30H43N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-9PD9L5 SCHEMBL25394514 3-[3-oxo-6-[[(1R,2S)-2-[[4-(trifluoromethoxy)cyclohexyl]amino]cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394514; SCHEMBL26250864; SCHEMBL26261670 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC(OC(F)(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C27H34F3N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-7IHGQ8 SCHEMBL25392401 3-[6-[1-[(1R,2S)-2-[(4,4-difluorocyclohexyl)amino]cyclohexyl]ethyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392401 CC(c1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)[C@H]1CCCC[C@@H]1NC1CCC(F)(F)CC1 Degrader C27H35F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-MV57OC SCHEMBL25392800 3-[6-[[(2R,3S)-3-(cyclopentylamino)oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392800 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NC4CCCC4)c3F)C2=O)C(=O)N1 Degrader C24H30FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-FL17UM SCHEMBL25392462 3-[6-[[(2R,3S)-3-[(4,4-difluorocyclohexyl)methylamino]oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392462 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NCC4CCC(F)(F)CC4)c3F)C2=O)C(=O)N1 Degrader C26H32F3N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-1YAD39 SCHEMBL25393066 3-[6-[[(1R,2S)-2-[(3,5-difluorophenyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393066 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCc4cc(F)cc(F)c4)ccc3C2=O)C(=O)N1 Degrader C27H29F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-E10WRM SCHEMBL25395658 3-[6-[[(2R,3S)-3-[(3,3-difluorocyclobutyl)methylamino]oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25395658 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NCC4CC(F)(F)C4)c3F)C2=O)C(=O)N1 Degrader C24H28F3N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-5GKM5N SCHEMBL25394834 3-[6-[[(2R,3S)-3-(cyclobutylmethylamino)oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394834 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NCC4CCC4)c3F)C2=O)C(=O)N1 Degrader C24H30FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-J30ZD6 SCHEMBL26254517 3-[6-[[(1R,2R,3R)-2-(cyclohexylamino)-3-fluorocyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL26254517 O=C1CCC(N2Cc3cc(C[C@H]4CCC[C@@H](F)[C@@H]4NC4CCCCC4)ccc3C2=O)C(=O)N1 Degrader C26H34FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-4V8ZNR SCHEMBL25392467 3-[6-[[(1S,2S,5R)-2-[(4,4-difluorocyclohexyl)amino]-5-hydroxy-5-methylcyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392467 C[C@@]1(O)CC[C@H](NC2CCC(F)(F)CC2)[C@@H](Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C27H35F2N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-EOKS1D SCHEMBL25391863 3-[6-[[(1S,2S,5S)-2-[(4,4-difluorocyclohexyl)amino]-5-hydroxy-5-methylcyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391863 C[C@]1(O)CC[C@H](NC2CCC(F)(F)CC2)[C@@H](Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C27H35F2N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-FA9BG5 SCHEMBL25393711 3-[7-fluoro-3-oxo-6-[[(2R,3S)-3-(spiro[3.3]heptan-2-ylamino)oxan-2-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393711 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NC4CC5(CCC5)C4)c3F)C2=O)C(=O)N1 Degrader C26H32FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-M6QBAI SCHEMBL25394833 3-[7-fluoro-3-oxo-6-[[(2R,3S)-3-(spiro[3.5]nonan-2-ylamino)oxan-2-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394833 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NC4CC5(CCCCC5)C4)c3F)C2=O)C(=O)N1 Degrader C28H36FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-AE4R60 SCHEMBL25391777 3-[7-fluoro-6-[[(2R,3S)-3-[(4-methoxycyclohexyl)amino]oxan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391777; SCHEMBL26255527; SCHEMBL26264891 COC1CCC(N[C@H]2CCCO[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C26H34FN3O5 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-D70MFK SCHEMBL25392759 3-[3-oxo-6-[[(1R,2S)-2-[[4-(trifluoromethyl)phenyl]methylamino]cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392759 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCc4ccc(C(F)(F)F)cc4)ccc3C2=O)C(=O)N1 Degrader C28H30F3N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-3MJ2JS SCHEMBL25395047 3-[6-[[(1S,2S,5R)-2-[(4,4-difluorocyclohexyl)amino]-5-hydroxycyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25395047 O=C1CCC(N2Cc3cc(C[C@H]4C[C@H](O)CC[C@@H]4NC4CCC(F)(F)CC4)ccc3C2=O)C(=O)N1 Degrader C26H33F2N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-TCFU4P SCHEMBL25391443 3-[6-[[(1R,2S)-2-[(2,2-dimethyl-1,3-dioxan-5-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391443 CC1(C)OCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CO1 Degrader C26H35N3O5 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-61Q8D1 SCHEMBL25392574 3-[6-[[(1S,2S,5S)-2-[(4,4-difluorocyclohexyl)amino]-5-hydroxycyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392574 O=C1CCC(N2Cc3cc(C[C@H]4C[C@@H](O)CC[C@@H]4NC4CCC(F)(F)CC4)ccc3C2=O)C(=O)N1 Degrader C26H33F2N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-F5YZTJ SCHEMBL25395779 3-[6-[[(1R,2R,3S)-2-[(4,4-difluorocyclohexyl)amino]-3-hydroxycyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25395779 O=C1CCC(N2Cc3cc(C[C@H]4CCC[C@H](O)[C@@H]4NC4CCC(F)(F)CC4)ccc3C2=O)C(=O)N1 Degrader C26H33F2N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-93XZYX SCHEMBL26254272 3-[6-[[(1R,2R,3R)-2-[(4,4-difluorocyclohexyl)amino]-3-methoxycyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL26254272 CO[C@@H]1CCC[C@H](Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)[C@H]1NC1CCC(F)(F)CC1 Degrader C27H35F2N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-5O255I SCHEMBL25393329 3-[3-oxo-6-[[(1R,2S)-2-(4,5,6,7-tetrahydro-1H-indazol-6-ylamino)cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393329 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCc5cn[nH]c5C4)ccc3C2=O)C(=O)N1 Degrader C27H33N5O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-HSFAIA SCHEMBL25394933 3-[6-[[(1R,2S)-2-(heptan-4-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394933 CCCC(CCC)N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C27H39N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-BUZYBF SCHEMBL25393471 3-[3-oxo-6-[[(1R,2S)-2-[(4-propan-2-yloxycyclohexyl)amino]cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393471; SCHEMBL26250952; SCHEMBL26250959 CC(C)OC1CCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C29H41N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-ZF2043 SCHEMBL25393336 3-[6-[[(1S,2S,5R)-2-[(4,4-difluorocyclohexyl)amino]-5-fluorocyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393336 O=C1CCC(N2Cc3cc(C[C@H]4C[C@H](F)CC[C@@H]4NC4CCC(F)(F)CC4)ccc3C2=O)C(=O)N1 Degrader C26H32F3N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-PZI5D9 SCHEMBL25393691 4-[[[(1S,2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]cyclohexyl]amino]methyl]-3-fluorobenzonitrile\; SCHEMBL25393691 N#Cc1ccc(CN[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c(F)c1 Degrader C28H29FN4O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-N4GL4X SCHEMBL26254284 3-[6-[[(1R,2R,3S)-2-(cyclohexylamino)-3-fluorocyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL26254284 O=C1CCC(N2Cc3cc(C[C@H]4CCC[C@H](F)[C@@H]4NC4CCCCC4)ccc3C2=O)C(=O)N1 Degrader C26H34FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-QKHFH9 SCHEMBL25394706 3-[6-[[(1R,2S)-2-(1-oxaspiro[3.5]nonan-7-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394706; SCHEMBL26250990; SCHEMBL26250993; SCHEMBL26251033 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC5(CCO5)CC4)ccc3C2=O)C(=O)N1 Degrader C28H37N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-T6JYZP SCHEMBL25392843 3-[7-fluoro-6-[[(2R,3S)-3-(oxepan-4-ylamino)oxan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392843 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NC4CCCOCC4)c3F)C2=O)C(=O)N1 Degrader C25H32FN3O5 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-QPDGX3 SCHEMBL25391610 3-[6-[[(1R,2S)-2-[(2,2-difluoro-3-phenyl-1-bicyclo[1.1.1]pentanyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391610 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCC45CC(c6ccccc6)(C4)C5(F)F)ccc3C2=O)C(=O)N1 Degrader C32H35F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-OXT2SM SCHEMBL25393156 3-[6-[[(1R,2S)-2-(3,4-dihydro-2H-chromen-4-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393156 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCOc5ccccc54)ccc3C2=O)C(=O)N1 Degrader C29H33N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-1Q6IKO SCHEMBL25394517 3-[6-[[(1R,2S)-2-(butan-2-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394517 CCC(C)N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H33N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-6D4FD1 SCHEMBL25391538 3-[6-[[(1R,2S)-2-(2,3-dihydro-1H-inden-2-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391538 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4Cc5ccccc5C4)ccc3C2=O)C(=O)N1 Degrader C29H33N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-WTJ0WA SCHEMBL25394305 3-[6-[[(1R,2S)-2-[(4,4-difluorocyclohexyl)amino]cyclopentyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394305 O=C1CCC(N2Cc3cc(C[C@H]4CCC[C@@H]4NC4CCC(F)(F)CC4)ccc3C2=O)C(=O)N1 Degrader C25H31F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-JEK5LR SCHEMBL25393547 3-[6-[[(1R,2S)-2-[(2,6-difluorophenyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393547 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCc4c(F)cccc4F)ccc3C2=O)C(=O)N1 Degrader C27H29F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-V588QU SCHEMBL25394328 3-[3-oxo-6-[[(2R,3S)-3-(propan-2-ylamino)oxan-2-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394328 CC(C)N[C@H]1CCCO[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H29N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-QLW0LW SCHEMBL25391575 3-[6-[[(2R,3S)-3-(cyclohexylamino)oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391575 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NC4CCCCC4)c3F)C2=O)C(=O)N1 Degrader C25H32FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-SYG7QD SCHEMBL25392143 3-[3-oxo-6-[[(1R,2S)-2-[(4,4,4-trifluoro-3,3-dimethylbutyl)amino]cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392143 CC(C)(CCN[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C(F)(F)F Degrader C26H34F3N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-H4O81S SCHEMBL25390964 3-[6-[[(1R,2S)-2-[(2,2-difluorocyclohexyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25390964 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCCCC4(F)F)ccc3C2=O)C(=O)N1 Degrader C26H33F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-FK89SZ SCHEMBL25394423 3-[6-[[(1R,2S)-2-(8-oxabicyclo[3.2.1]octan-3-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394423 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CC5CCC(C4)O5)ccc3C2=O)C(=O)N1 Degrader C27H35N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-L8ZN14 SCHEMBL25392585 3-[6-[[(1R,2S)-2-(4-methylpentan-2-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392585 CC(C)CC(C)N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C26H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-A42190 SCHEMBL25393346 3-[7-fluoro-6-[[(1R,2S)-2-(oxetan-3-ylmethylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393346 O=C1CCC(N2Cc3c(ccc(C[C@H]4CCCC[C@@H]4NCC4COC4)c3F)C2=O)C(=O)N1 Degrader C24H30FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-MOII7Z SCHEMBL25391553 3-[7-fluoro-6-[[(1R,2S)-2-(oxan-4-ylmethylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391553 O=C1CCC(N2Cc3c(ccc(C[C@H]4CCCC[C@@H]4NCC4CCOCC4)c3F)C2=O)C(=O)N1 Degrader C26H34FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-1UA8X8 SCHEMBL25392330 3-[7-fluoro-6-[[(1R,2S)-2-(oxan-4-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392330 O=C1CCC(N2Cc3c(ccc(C[C@H]4CCCC[C@@H]4NC4CCOCC4)c3F)C2=O)C(=O)N1 Degrader C25H32FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-KPGOWO SCHEMBL25394406 3-[6-[[(1R,2S)-2-[(2,4-difluorophenyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394406 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCc4ccc(F)cc4F)ccc3C2=O)C(=O)N1 Degrader C27H29F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-3T9B4G SCHEMBL25393322 3-[7-fluoro-3-oxo-6-[[(1R,2S)-2-(oxolan-3-ylamino)cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393322 O=C1CCC(N2Cc3c(ccc(C[C@H]4CCCC[C@@H]4NC4CCOC4)c3F)C2=O)C(=O)N1 Degrader C24H30FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-HJ8UHF SCHEMBL25392799 3-[6-[[(1R,2S)-2-(3-bicyclo[3.2.1]octanylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392799 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CC5CCC(C5)C4)ccc3C2=O)C(=O)N1 Degrader C28H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-GFKVB4 SCHEMBL25391527 3-[6-[[(1R,2S)-2-[(3,3-dimethyloxan-4-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391527 CC1(C)COCCC1N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C27H37N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-N4NXT8 SCHEMBL25391710 3-[6-[[(1R,2S)-2-(7-oxabicyclo[2.2.1]heptan-2-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391710 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CC5CCC4O5)ccc3C2=O)C(=O)N1 Degrader C26H33N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-U86QJD SCHEMBL25391882 3-[6-[[(1R,2S)-2-(3-oxabicyclo[3.2.1]octan-8-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391882 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4C5CCC4COC5)ccc3C2=O)C(=O)N1 Degrader C27H35N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-L9VRK3 SCHEMBL25392844 3-[6-[[(1R,2S)-2-(6,8-dioxabicyclo[3.2.1]octan-4-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392844 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC5COC4O5)ccc3C2=O)C(=O)N1 Degrader C26H33N3O5 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-1F5GZ1 SCHEMBL25392620 3-[6-[[(1R,2S)-2-(cycloheptylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392620 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCCCCC4)ccc3C2=O)C(=O)N1 Degrader C27H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-XOAEDV SCHEMBL25393372 3-[6-[[(1R,2S)-2-(oxepan-4-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393372 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCCOCC4)ccc3C2=O)C(=O)N1 Degrader C26H35N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-3XRZSB SCHEMBL25390659 3-[6-[[(1R,2S)-2-[[(3aR,6aS)-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]furan-5-yl]amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25390659 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4C[C@H]5COC[C@H]5C4)ccc3C2=O)C(=O)N1 Degrader C27H35N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-FHRXDM SCHEMBL25392058 3-[6-[[(1R,2S)-2-(8-bicyclo[3.2.1]octanylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392058 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4C5CCCC4CC5)ccc3C2=O)C(=O)N1 Degrader C28H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-CX2726 SCHEMBL25393073 4-[[[(1S,2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]cyclohexyl]amino]methyl]benzonitrile\; SCHEMBL25393073 N#Cc1ccc(CN[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C28H30N4O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-JDR3H6 SCHEMBL25392473 3-[6-[[(1R,2S)-2-[1-(oxan-4-yl)ethylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392473 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCOCC1 Degrader C27H37N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-RB7F5I SCHEMBL25392010 3-[6-[[(1R,2S)-2-(1-cyclohexylethylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392010 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCCCC1 Degrader C28H39N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-48Z2NM SCHEMBL25395964 3-[6-[[(1R,2S)-2-(1-cyclopropylpropan-2-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25395964 CC(CC1CC1)N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C26H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-90D3NJ SCHEMBL25394553 3-[6-[[(1R,2S)-2-(4,4-dimethylpentan-2-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394553 CC(CC(C)(C)C)N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C27H39N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-TGVFJL SCHEMBL25390783 3-[6-[[(1R,2S)-2-[1-(1-methylcyclobutyl)ethylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25390783 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1(C)CCC1 Degrader C27H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-QY3ENJ SCHEMBL25393064 3-[3-oxo-6-[[(1R,2S)-2-[(2,2,6,6-tetramethyloxan-4-yl)amino]cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393064 CC1(C)CC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC(C)(C)O1 Degrader C29H41N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-C52JCS WO2023178181-A1_209 . CC1(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CCC(F)(F)CC1 Degrader C27H34F3N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-S10LPT SCHEMBL25395035 3-[6-[[(1R,2S)-2-[benzyl(methyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25395035 CN(Cc1ccccc1)[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C28H33N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-VWYQY3 WO2023178181-A1_210 . CC1(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CCC2(CC2)CC1 Degrader C29H38FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-ZJZA3E WO2023178181-A1_211 . CC1(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CCCCC1 Degrader C27H36FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-IIUFUR SCHEMBL26251842 3-[7-fluoro-6-[[(1R,2S)-2-[(1-methylcyclopentyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL26251842 CC1(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CCCC1 Degrader C26H34FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-PC6D89 WO2023178181-A1_213 . CC1(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CC2(CC2)C1 Degrader C27H34FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-380FXO WO2023178181-A1_214 . CC1(C)CC(C)(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C27H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-5GRRNT SCHEMBL26258788 3-[6-[[(1R,2S)-2-[(1-methylcyclohexyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL26258788 CC1(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CCCCC1 Degrader C27H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-1EG22O SCHEMBL25392827 3-[6-[[(1R,2S)-2-[[4-(difluoromethyl)cyclohexyl]amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392827; SCHEMBL26251961; SCHEMBL26252028 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC(C(F)F)CC4)ccc3C2=O)C(=O)N1 Degrader C27H35F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-P7D6MH SCHEMBL25391747 3-[6-[[(1R,2S)-2-(1-cyclobutylethylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391747 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCC1 Degrader C26H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-D3CFOM SCHEMBL25393817 3-[6-[[(1R,2S)-2-[(2,5-difluorophenyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393817 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCc4cc(F)ccc4F)ccc3C2=O)C(=O)N1 Degrader C27H29F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-TDZDJ9 SCHEMBL25391586 3-[6-[[(2R,3S)-3-[(2,2-dimethyloxan-4-yl)amino]oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391586 CC1(C)CC(N[C@H]2CCCO[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CCO1 Degrader C26H34FN3O5 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-4ZHTIH SCHEMBL25392130 3-[6-[[(1R,2S)-2-[1-(1-fluorocyclopropyl)ethylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392130 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1(F)CC1 Degrader C25H32FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-7DCZ3K SCHEMBL26252309 3-[6-[[(1R,2S)-2-[(3-fluoro-3-methylbutan-2-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL26252309 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C(C)(C)F Degrader C25H34FN3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-6UDD8W SCHEMBL25391525 3-[3-oxo-6-[[(1R,2S)-2-(spiro[2.5]octan-8-ylamino)cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391525 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCCCC45CC5)ccc3C2=O)C(=O)N1 Degrader C28H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-EW2TQG SCHEMBL25391583 3-[3-oxo-6-[[(1R,2S)-2-(pentan-3-ylamino)cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391583 CCC(CC)N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-4WHC5C SCHEMBL25392999 3-[6-[[(1R,2S)-2-(1-cyclopropylpropylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392999 CCC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CC1 Degrader C26H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-EQRPA3 SCHEMBL25394518 3-[6-[[(1R,2S)-2-[1-(1-methylcyclopropyl)ethylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394518 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1(C)CC1 Degrader C26H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-MCEM0I SCHEMBL25392960 3-[6-[[(1R,2S)-2-[[(3S)-3-methylcyclohexyl]amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392960 C[C@H]1CCCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C27H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-8UNMAC SCHEMBL25392097 3-[6-[[(1R,2S)-2-[(3,3-difluorocyclobutyl)methylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392097 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NCC4CC(F)(F)C4)ccc3C2=O)C(=O)N1 Degrader C25H31F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-CF5A5O SCHEMBL25393368 3-[6-[[(2R,3S)-3-(1-cyclobutylethylamino)oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393368 CC(N[C@H]1CCCO[C@@H]1Cc1ccc2c(c1F)CN(C1CCC(=O)NC1=O)C2=O)C1CCC1 Degrader C25H32FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-ND23VG WO2023178181-A1_25 . Cc1c(C)c(C)c(CN[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c(C)c1C Degrader C32H41N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-R9XH4T SCHEMBL25394036 3-[3-oxo-6-[[(1R,2S)-2-(4,4,4-trifluorobutan-2-ylamino)cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394036 CC(CC(F)(F)F)N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H30F3N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-P185FR SCHEMBL25390440 3-[6-[[(1R,2S)-2-[[4-(methoxymethyl)cyclohexyl]amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25390440; SCHEMBL26253249; SCHEMBL26253251; SCHEMBL26263056 COCC1CCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C28H39N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-MZ55D0 SCHEMBL25391365 3-[3-oxo-6-[[(1R,2S)-2-[1-(oxolan-2-yl)ethylamino]cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391365 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCCO1 Degrader C26H35N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-NRID17 SCHEMBL25394563 1-[1-[[(1S,2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]cyclohexyl]amino]ethyl]cyclopropane-1-carbonitrile\; SCHEMBL25394563 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1(C#N)CC1 Degrader C26H32N4O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-BTNDBO SCHEMBL26247785 3-[7-fluoro-3-oxo-6-[[(2R,3S)-3-[[4-(trifluoromethyl)cyclohexyl]amino]oxan-2-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL26247785; SCHEMBL26247789 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NC4CCC(C(F)(F)F)CC4)c3F)C2=O)C(=O)N1 Degrader C26H31F4N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-IH5TLD SCHEMBL25390612 3-[6-[[(2R,3S)-3-[(3,3-dimethylcyclopentyl)amino]oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25390612 CC1(C)CCC(N[C@H]2CCCO[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C26H34FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-BW7750 WO2023178181-A1_26 . Cc1c(C)c(C)c(CN(Cc2c(C)c(C)c(C)c(C)c2C)[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c(C)c1C Degrader C44H57N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-J1ZRTG SCHEMBL25394840 3-[6-[[(1R,2S)-2-(oxan-3-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394840 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCCOC4)ccc3C2=O)C(=O)N1 Degrader C25H33N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-IAY43H SCHEMBL25392285 3-[7-fluoro-6-[[(2R,3S)-3-(oxan-3-ylamino)oxan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392285 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NC4CCCOC4)c3F)C2=O)C(=O)N1 Degrader C24H30FN3O5 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-9UCN1G SCHEMBL25394351 3-[7-fluoro-6-[[(2R,3S)-3-[[4-(methoxymethyl)cyclohexyl]amino]oxan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394351; SCHEMBL26255863; SCHEMBL26265192 COCC1CCC(N[C@H]2CCCO[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C27H36FN3O5 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-V39VXB SCHEMBL25394470 3-[6-[[(1R,2S)-2-(3-bicyclo[3.1.0]hexanylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394470 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CC5CC5C4)ccc3C2=O)C(=O)N1 Degrader C26H33N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-AA1LOU SCHEMBL25392316 4-[[(1S,2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]cyclohexyl]amino]cyclohexane-1-carbonitrile\; SCHEMBL25392316 N#CC1CCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C27H34N4O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-4YA5EX SCHEMBL25392350 3-[6-[[(1R,2S)-2-[(4,4-dimethylcyclohexyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392350 CC1(C)CCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C28H39N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-U5R8ZU SCHEMBL25393267 2-[4-[[(1S,2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]cyclohexyl]amino]cyclohexyl]acetonitrile\; SCHEMBL25393267 N#CCC1CCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C28H36N4O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-5WJM8M SCHEMBL25393072 3-[6-[[(1R,2S)-2-[(2,2-difluorospiro[2.5]octan-6-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393072; SCHEMBL26246840; SCHEMBL26246842 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC5(CC4)CC5(F)F)ccc3C2=O)C(=O)N1 Degrader C28H35F2N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-SISQDW SCHEMBL25392732 3-[6-[[(1R,2S)-2-[(2,2-dimethyloxolan-3-yl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392732 CC1(C)OCCC1N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C26H35N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-4KI6HE SCHEMBL25393950 3-[6-[[(1R,2S)-2-[(3,3-dimethylcyclohexyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393950 CC1(C)CCCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C28H39N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-M3UQ80 SCHEMBL25392095 3-[6-[[(1R,2S)-2-[(4-methoxycyclohexyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392095; SCHEMBL26253884 COC1CCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C27H37N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-XIX9TI SCHEMBL25393315 3-[3-oxo-6-[[(1R,2S)-2-(spiro[2.5]octan-6-ylamino)cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393315 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC5(CC4)CC5)ccc3C2=O)C(=O)N1 Degrader C28H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-ZUVGWY SCHEMBL25390362 3-[6-[[(1R,2S)-2-[(4-methylcyclohexyl)amino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25390362; SCHEMBL26253606; SCHEMBL26263370 CC1CCC(N[C@H]2CCCC[C@@H]2Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C27H37N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-KD7D1J SCHEMBL25391204 3-[3-oxo-6-[[(1R,2S)-2-(spiro[2.4]heptan-6-ylamino)cyclohexyl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391204 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC5(CC5)C4)ccc3C2=O)C(=O)N1 Degrader C27H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-W7AOKZ SCHEMBL25393172 3-[6-[[(2R,3S)-3-[[4-(difluoromethyl)cyclohexyl]amino]oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393172; SCHEMBL26247845; SCHEMBL26247848; SCHEMBL26259802 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4NC4CCC(C(F)F)CC4)c3F)C2=O)C(=O)N1 Degrader C26H32F3N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-PAJI86 SCHEMBL25392966 3-[7-fluoro-3-oxo-6-[[(2R,3S)-3-[(4-propan-2-yloxycyclohexyl)amino]oxan-2-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25392966; SCHEMBL26255954; SCHEMBL26255980 CC(C)OC1CCC(N[C@H]2CCCO[C@@H]2Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CC1 Degrader C28H38FN3O5 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-U6885I SCHEMBL25394408 3-[6-[[(1R,2S)-2-(2-oxaspiro[3.3]heptan-7-ylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394408 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC45COC5)ccc3C2=O)C(=O)N1 Degrader C26H33N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-YEI6YE SCHEMBL25393496 3-[7-fluoro-6-[[(1R,2S)-2-[1-(oxan-4-yl)ethylamino]cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25393496 CC(N[C@H]1CCCC[C@@H]1Cc1ccc2c(c1F)CN(C1CCC(=O)NC1=O)C2=O)C1CCOCC1 Degrader C27H36FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-UN8TBE WO-2023178181-A1_289 3-[7-fluoro-6-[[(2R,3S)-3-[(4-fluorocyclohexyl)amino]oxan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391633; SCHEMBL26247984; SCHEMBL26254462 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4N[C@H]4CC[C@H](F)CC4)c3F)C2=O)C(=O)N1 Degrader C25H31F2N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-LDT7ZR SCHEMBL25391870 3-[6-[[(1R,2S)-2-(3-bicyclo[3.1.1]heptanylamino)cyclohexyl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391870 O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CC5CC(C5)C4)ccc3C2=O)C(=O)N1 Degrader C27H35N3O3 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-K87CRL WO-2023178181-A1_290 3-[7-fluoro-6-[[(2R,3S)-3-[(4-fluorocyclohexyl)amino]oxan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25391633; SCHEMBL26247984; SCHEMBL26254462 O=C1CCC(N2Cc3c(ccc(C[C@H]4OCCC[C@@H]4N[C@H]4CC[C@@H](F)CC4)c3F)C2=O)C(=O)N1 Degrader C25H31F2N3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-61HRCP SCHEMBL25394684 3-[6-[[(2R,3S)-3-(butan-2-ylamino)oxan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL25394684 CCC(C)N[C@H]1CCCO[C@@H]1Cc1ccc2c(c1F)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H30FN3O4 IKZF1;IKZF2 Q13422/Q9UKS7 CRBN WO-2023178181-A1 TPD-YEGQCA SCHEMBL26603073 (3R)-1-(3-chlorophenyl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxamide\; SCHEMBL26603073; SCHEMBL26603221 O=C(Nc1cc(C2CC2)n[nH]1)[C@@H]1CC(=O)N(c2cccc(Cl)c2)C1 Degrader C17H17ClN4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023203172-A1 TPD-7X1GRV SCHEMBL26603025 (3R)-1-(4-chloro-3-methylphenyl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxamide\; SCHEMBL26603025; SCHEMBL26603057 Cc1cc(N2C[C@H](C(=O)Nc3cc(C4CC4)n[nH]3)CC2=O)ccc1Cl Degrader C18H19ClN4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023203172-A1 TPD-XD2V4U SCHEMBL26603129 (3S)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-1-(4-fluoro-3-methylphenyl)-5-oxopyrrolidine-3-carboxamide\; SCHEMBL26603129; SCHEMBL26603227 Cc1cc(N2C[C@@H](C(=O)Nc3cc(C4CC4)n[nH]3)CC2=O)ccc1F Degrader C18H19FN4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023203172-A1 TPD-2G4ODW SCHEMBL26603068 (3R)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-1-(4-fluoro-3-methylphenyl)-5-oxopyrrolidine-3-carboxamide\; SCHEMBL26603068; SCHEMBL26603154 Cc1cc(N2C[C@H](C(=O)Nc3cc(C4CC4)n[nH]3)CC2=O)ccc1F Degrader C18H19FN4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023203172-A1 TPD-VECGQT SCHEMBL26603061 (3S)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-1-[3-(difluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxamide\; SCHEMBL26603061; SCHEMBL26603225 O=C(Nc1cc(C2CC2)n[nH]1)[C@H]1CC(=O)N(c2cccc(C(F)F)c2)C1 Degrader C18H18F2N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023203172-A1 TPD-JPUTGA SCHEMBL26603027 (3R)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-1-[3-(difluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxamide\; SCHEMBL26603027; SCHEMBL26603030 O=C(Nc1cc(C2CC2)n[nH]1)[C@@H]1CC(=O)N(c2cccc(C(F)F)c2)C1 Degrader C18H18F2N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023203172-A1 TPD-YJROBF SCHEMBL26603104 (3S)-1-(3-chlorophenyl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxamide\; SCHEMBL26603104; SCHEMBL26603114 O=C(Nc1cc(C2CC2)n[nH]1)[C@H]1CC(=O)N(c2cccc(Cl)c2)C1 Degrader C17H17ClN4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023203172-A1 TPD-CB2XHD WO2023237116-A1_A1 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCCC(F)C5)c4)c3C2=O)C(=O)N1 Degrader C27H27FN4O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-74W7WN WO2023237116-A1_A10 . Cn1c(C2CCC(NC(=O)C3CC(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)nc2ccncc21 Degrader C32H35N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-NSH6GF WO2023237116-A1_A100' . O=C1CCC(N2C(=O)c3cccc(NCc4cccc5c4CCCN5C(=O)[C@H]4CC[C@H](c5nc6cccnc6s5)CC4)c3C2=O)C(=O)N1 Degrader C36H34N6O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-3I6919 WO2023237116-A1_A100 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc5c4CCCN5C(=O)C4CCC(c5nc6cccnc6s5)CC4)c3C2=O)C(=O)N1 Degrader C36H34N6O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-146ZDS WO2023237116-A1_A101' . COc1ccc2c(c1)nc([C@H]1CC[C@H](N(C)C(=O)c3cc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ccn3)CC1)n2C Degrader C36H37N7O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-D8QT15 WO2023237116-A1_A101 . COc1ccc2c(c1)nc(C1CCC(N(C)C(=O)c3cc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ccn3)CC1)n2C Degrader C36H37N7O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-VVGS8L WO2023237116-A1_A102' . CN(C)c1cc2c(cn1)nc([C@H]1CC[C@H](NC(=O)c3cc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ccn3)CC1)n2C Degrader C35H37N9O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-WUY4OR WO2023237116-A1_A102 . CN(C)c1cc2c(cn1)NC(C1CCC(NC(=O)c3cc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ccn3)CC1)N2C Degrader C35H39N9O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-NLS09N WO2023237116-A1_A103' . CNCCN(C(=O)c1cc(CNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccn1)[C@H]1CC[C@H](c2nc3cccnc3s2)CC1 Degrader C35H36N8O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-AAUYSC WO2023237116-A1_A103 . CNCCN(C(=O)c1cc(CNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccn1)C1CCC(c2nc3cccnc3s2)CC1 Degrader C35H36N8O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-QM61AP WO2023237116-A1_A104 . O=C1CCC(N2C(=O)c3cccc(NCCCCC(=O)Nc4ccc(-c5nc6cnc7[nH]cc(C8CCOCC8)c7c6[nH]5)cc4)c3C2=O)C(=O)N1 Degrader C37H36N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-7MHL95 WO2023237116-A1_A105 . O=C1CCC(N2C(=O)c3cccc(NCCCCC(=O)NC4CCC(c5nc6c(cnc7[nH]cc(C8CCOCC8)c76)[nH]5)CC4)c3C2=O)C(=O)N1 Degrader C37H42N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-TJD5YK WO2023237116-A1_A106 . Cn1c(C2CCC(NC(=O)CCCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)nc2c3c(C4CCCCC4)c[nH]c3ncc21 Degrader C39H46N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-JSK1AR WO2023237116-A1_A107' . O=C1CCC(N2C(=O)c3cccc(NCc4cc(C(=O)N[C@H]5CC[C@H](c6nc7cccnc7s6)CC5)ncc4N4CCNCC4)c3C2=O)C(=O)N1 Degrader C36H37N9O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-Y2O7T3 WO2023237116-A1_A107 . O=C1CCC(N2C(=O)c3cccc(NCc4cc(C(=O)NC5CCC(c6nc7cccnc7s6)CC5)ncc4N4CCNCC4)c3C2=O)C(=O)N1 Degrader C36H37N9O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-L3FUL2 WO2023237116-A1_A108 . Cn1cc(C2CCOCC2)c2c3nc(C4CCC(NC(=O)CCCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)[nH]c3cnc21 Degrader C38H44N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-ELEQAD WO2023237116-A1_A109 . Cn1c(C2CCC(NC(=O)CCCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)nc2c3c(C4CCOCC4)c[nH]c3ncc21 Degrader C38H44N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-GX22YK WO2023237116-A1_A11 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6cc7ccccc7[nH]6)CC5)c4)c3C2=O)C(=O)N1 Degrader C35H33N5O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-4SK1TK WO2023237116-A1_A110 . O=C1CCC(N2C(=O)c3cccc(Nc4cccc(C(=O)NC5CCC(c6nc7c(cnc8[nH]cc(C9CCOCC9)c87)[nH]6)CC5)c4)c3C2=O)C(=O)N1 Degrader C39H38N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-O1S9LL WO2023237116-A1_A111 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6nc7c(cnc8[nH]cc(C9CCOCC9)c87)[nH]6)CC5)c4)c3C2=O)C(=O)N1 Degrader C40H40N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-WRPZ4I WO2023237116-A1_A112 . O=C1CCC(N2C(=O)c3cccc(NCc4ccc(C(=O)NC5CCC(c6nc7c(cnc8[nH]cc(C9CCOCC9)c87)[nH]6)CC5)cc4)c3C2=O)C(=O)N1 Degrader C40H40N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-RM2QMM WO2023237116-A1_A113 . Cn1c(C2CCC(NC(=O)C3CC3CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)nc2ccncc21 Degrader C31H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-36WJL7 WO2023237116-A1_A114 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6nc7cccnc7o6)CC5)c4)c3C2=O)C(=O)N1 Degrader C33H30N6O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-HNVGOH WO2023237116-A1_A115 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6nc7cncnc7[nH]6)CC5)c4)c3C2=O)C(=O)N1 Degrader C32H30N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-D2WJ7H WO2023237116-A1_A116' . Cn1c2cnccc2nc1[C@H]1CC[C@H](COc2cccc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)c2)CC1 Degrader C34H34N6O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-ALQWRR WO2023237116-A1_A116 . Cn1c(C2CCC(COc3cccc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)CC2)nc2ccncc21 Degrader C34H34N6O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-PJH52Z WO2023237116-A1_A117 . O=C1CCC(N2C(=O)c3cccc(NCCCCC(=O)Nc4ccc(-c5cn6c(cnc7[nH]cc(C8CCOCC8)c76)n5)cc4)c3C2=O)C(=O)N1 Degrader C37H36N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-8PPADF WO2023237116-A1_A118 . O=C1CCC(N2C(=O)c3cccc(NCc4ccc5c(c4)C(=O)N(C4CCC(c6nc7c(cnc8[nH]cc(C9CCOCC9)c87)[nH]6)CC4)CC5)c3C2=O)C(=O)N1 Degrader C42H42N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-RN2OEN WO2023237116-A1_A119 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc5c4CCN(C4CCC(c6nc7c(cnc8[nH]cc(C9CCOCC9)c87)[nH]6)CC4)C5=O)c3C2=O)C(=O)N1 Degrader C42H42N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-6NQIDY WO2023237116-A1_A12 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6cc7ccccc7o6)CC5)c4)c3C2=O)C(=O)N1 Degrader C35H32N4O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-ULN8NE WO2023237116-A1_A120 . O=C1CCC(N2C(=O)c3cccc(NCCC4(CC(=O)NC5CCC(c6nc7c(cnc8[nH]cc(C9CCOCC9)c87)[nH]6)CC5)CCCCC4)c3C2=O)C(=O)N1 Degrader C42H50N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-UD8U5J WO2023237116-A1_A121 . O=C1CCC(N2C(=O)c3cccc(NCC4(CCC(=O)NC5CCC(c6nc7c(cnc8[nH]cc(C9CCOCC9)c87)[nH]6)CC5)CCCCC4)c3C2=O)C(=O)N1 Degrader C42H50N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-LG6GDO WO2023237116-A1_A122 . O=C1CCC(N2C(=O)c3cccc(NCc4ccc5cnc(C6CCC(c7nc8cccnc8s7)CC6)cc5c4)c3C2=O)C(=O)N1 Degrader C35H30N6O4S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-LVXT96 WO2023237116-A1_A123 . Cn1ccc2c3nc(C4CCC(NC(=O)c5cc(CNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)ccn5)CC4)[nH]c3cnc21 Degrader C35H33N9O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-J0HA5P WO2023237116-A1_A124 . Cn1c(C2CCC(N3CCc4ccc(CNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)cc4C3=O)CC2)nc2ccncc21 Degrader C36H35N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-8M8GWX WO2023237116-A1_A125 . COc1ccc2c(c1)nc(C1CCC(N3Cc4ccc(CNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)cc4C3=O)CC1)n2C Degrader C37H36N6O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-TVXLU6 WO2023237116-A1_A13 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6coc7ccccc67)CC5)c4)c3C2=O)C(=O)N1 Degrader C35H32N4O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-QJRHGJ WO2023237116-A1_A14 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6n[nH]c7ccccc67)CC5)c4)c3C2=O)C(=O)N1 Degrader C34H32N6O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-LFJJVM WO2023237116-A1_A15 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6nc7ccccc7o6)CC5)c4)c3C2=O)C(=O)N1 Degrader C34H31N5O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-S8AR6U WO2023237116-A1_A16 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6nc7cccnc7[nH]6)CC5)c4)c3C2=O)C(=O)N1 Degrader C33H31N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-SGBGU5 WO2023237116-A1_A17 . O=C1CCC(N2C(=O)c3cccc(NCc4ccnc(C(=O)NC5CCC(c6nc7ccccc7[nH]6)CC5)c4)c3C2=O)C(=O)N1 Degrader C33H31N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-TZBBQO WO2023237116-A1_A18 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6n[nH]c7ccncc67)CC5)c4)c3C2=O)C(=O)N1 Degrader C33H31N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-EWQ0KL WO2023237116-A1_A19 . Cn1c(C2CCC(NC(=O)c3cccc(CNc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c3)CC2)nc2ccncc21 Degrader C34H35N7O4 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-W9LDFI WO2023237116-A1_A2 . COC1CCCC(NC(=O)c2cccc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)c2)C1 Degrader C28H30N4O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-HMWRL3 WO2023237116-A1_A20 . O=C1CCC(N2C(=O)c3cccc(NCc4ccnc(C(=O)NC5CCC(C6=NC7CC=CC=C7O6)CC5)c4)c3C2=O)C(=O)N1 Degrader C33H32N6O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-WS3EEH WO2023237116-A1_A21 . O=C1CCC(N2C(=O)c3cccc(NCc4ccnc(C(=O)NC5CCC(c6nc7ccncc7[nH]6)CC5)c4)c3C2=O)C(=O)N1 Degrader C32H30N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-Y2K5PY WO2023237116-A1_A22 . Cn1c(C2CCC(NC(=O)c3cc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ncn3)CC2)nc2ccncc21 Degrader C32H31N9O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-7V2D4W WO2023237116-A1_A23 . Cn1c(C2CCC(NC(=O)c3cc(CNc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)ccn3)CC2)nc2ccncc21 Degrader C33H34N8O4 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-N7Y45A WO2023237116-A1_A24' . Cn1c2cnccc2nc1[C@H]1CC[C@H](NC(=O)c2cc(COc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)ccn2)CC1 Degrader C33H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-BLG4F6 WO2023237116-A1_A24 . Cn1c(C2CCC(NC(=O)c3cc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)ccn3)CC2)nc2ccncc21 Degrader C33H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-2MSIAY WO2023237116-A1_A25 . Cn1c(N2CCC(NC(=O)c3cccc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)CC2=O)nc2ccncc21 Degrader C33H30N8O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-UJF6QY WO2023237116-A1_A26' . O=C1CCC(N2C(=O)c3cccc(NCc4ccnc(NC[C@H]5CC[C@H](c6nc7cccnc7s6)CC5)c4)c3C2=O)C(=O)N1 Degrader C32H31N7O4S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-EAMWRY WO2023237116-A1_A26 . O=C1CCC(N2C(=O)c3cccc(NCc4ccnc(NCC5CCC(c6nc7cccnc7s6)CC5)c4)c3C2=O)C(=O)N1 Degrader C32H31N7O4S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-CI99KU WO2023237116-A1_A27 . O=C1CCC(N2C(=O)c3cccc(NCCCCC(=O)NC4CCC(c5nc6c(cnc7[nH]ccc76)[nH]5)CC4)c3C2=O)C(=O)N1 Degrader C32H34N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-1F3P8T WO2023237116-A1_A28' . O=C1CCC(N2Cc3c(OCc4ccnc(C(=O)N[C@H]5CC[C@H](c6nc7cccnc7s6)CC5)c4)cccc3C2=O)C(=O)N1 Degrader C32H30N6O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-MW4APU WO2023237116-A1_A28 . O=C1CCC(N2Cc3c(OCc4ccnc(C(=O)NC5CCC(c6nc7cccnc7s6)CC5)c4)cccc3C2=O)C(=O)N1 Degrader C32H30N6O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-3FKXNH WO2023237116-A1_A29' . O=C1CCC(N2C(=O)c3cccc(NCc4cc(OC[C@H]5CC[C@H](c6nc7cccnc7s6)CC5)ccn4)c3C2=O)C(=O)N1 Degrader C32H30N6O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-EPEXNH WO2023237116-A1_A29 . O=C1CCC(N2C(=O)c3cccc(NCc4cc(OCC5CCC(c6nc7cccnc7s6)CC5)ccn4)c3C2=O)C(=O)N1 Degrader C32H30N6O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-KFD7ON WO2023237116-A1_A3 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCCC(F)(F)C5)c4)c3C2=O)C(=O)N1 Degrader C27H26F2N4O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-G6C39F WO2023237116-A1_A30 . Cn1c(C2CCC(NC(=O)c3cccc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)CC2)cc2ccccc21 Degrader C36H35N5O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-BWWFVE WO2023237116-A1_A31 . Cn1c(C2CCC(NC(=O)c3cccc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)CC2)nc2ccccc21 Degrader C35H34N6O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-F56C62 WO2023237116-A1_A32' . Cn1c2cnccc2nc1[C@H]1CC[C@H](NC(=O)c2cccc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)c2)CC1 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-Y9WC4F WO2023237116-A1_A32 . Cn1c(C2CCC(NC(=O)c3cccc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)CC2)nc2ccncc21 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-LVHD0Q WO2023237116-A1_A33' . Cn1c2ccccc2nc1[C@H]1CC[C@H](NC(=O)c2cc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)ccn2)CC1 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-BDF0IF WO2023237116-A1_A33 . Cn1c(C2CCC(NC(=O)c3cc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ccn3)CC2)nc2ccccc21 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-VLX3EP WO2023237116-A1_A34' . Cn1c2ccncc2nc1[C@H]1CC[C@H](C(=O)Nc2cccc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)c2)CC1 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-FT1TE1 WO2023237116-A1_A34 . Cn1c(C2CCC(C(=O)Nc3cccc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)CC2)nc2cnccc21 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-6ETEAW WO2023237116-A1_A35' . Cn1c2cnccc2nc1[C@H]1CC[C@H](C(=O)Nc2cccc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)c2)CC1 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-FNOK4J WO2023237116-A1_A35 . Cn1c(C2CCC(C(=O)Nc3cccc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)CC2)nc2ccncc21 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-MS1HXA WO2023237116-A1_A36' . O=C1CCC(N2C(=O)c3cccc(NCc4ccc5cn([C@H]6CC[C@H](c7nc8cccnc8s7)CC6)nc5c4)c3C2=O)C(=O)N1 Degrader C33H29N7O4S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-GB9XXW WO2023237116-A1_A36 . O=C1CCC(N2C(=O)c3cccc(NCc4ccc5cn(C6CCC(c7nc8cccnc8s7)CC6)nc5c4)c3C2=O)C(=O)N1 Degrader C33H29N7O4S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-7QU7SM WO2023237116-A1_A37 . Cn1c(C2CCC(NC(=O)c3cc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ccn3)CC2)nc2ccncc21 Degrader C33H32N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-G3TQR7 WO2023237116-A1_A38 . Cn1c(C2CCC(NC(=O)c3cccc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)n3)CC2)nc2ccncc21 Degrader C33H32N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-E7U4CZ WO2023237116-A1_A39 . Cn1c(N2CCC(NC(=O)c3cc(CNC4=CC=CC5C(=O)N(C6CCC(=O)NC6=O)C(=O)C45)ccn3)CC2)nc2ccccc21 Degrader C33H34N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-ZM5BBA WO2023237116-A1_A4 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6ccccc6)CC5)c4)c3C2=O)C(=O)N1 Degrader C33H32N4O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-GX6STU WO2023237116-A1_A40' . Cn1c2cccnc2nc1[C@H]1CC[C@H](NC(=O)c2cc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)ccn2)CC1 Degrader C33H32N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-4YWX9Q WO2023237116-A1_A40 . Cn1c(C2CCC(NC(=O)c3cc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ccn3)CC2)nc2ncccc21 Degrader C33H32N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-1DP98L WO2023237116-A1_A41' . Cn1c2ncccc2nc1[C@H]1CC[C@H](NC(=O)c2cc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)ccn2)CC1 Degrader C33H32N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-22CDCM WO2023237116-A1_A41 . Cn1c(C2CCC(NC(=O)c3cc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ccn3)CC2)nc2cccnc21 Degrader C33H32N8O5 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-MRFC65 WO2023237116-A1_A42 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6cc7ccccc7s6)CC5)c4)c3C2=O)C(=O)N1 Degrader C35H32N4O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-VN2BVD WO2023237116-A1_A43' . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)N[C@H]5CC[C@H](c6csc7ccccc76)CC5)c4)c3C2=O)C(=O)N1 Degrader C35H32N4O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-ACN3IC WO2023237116-A1_A43 . O=C1CCC(N2C(=O)c3cccc(NCc4cccc(C(=O)NC5CCC(c6csc7ccccc67)CC5)c4)c3C2=O)C(=O)N1 Degrader C35H32N4O5S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-3SIJ7N WO2023237116-A1_A44' . O=C1CCC(N2C(=O)c3cccc(NCc4ccc5c(c4)CN([C@H]4CC[C@H](c6nc7cccnc7s6)CC4)C5)c3C2=O)C(=O)N1 Degrader C34H32N6O4S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-VWUHXC WO2023237116-A1_A44 . O=C1CCC(N2C(=O)c3cccc(NCc4ccc5c(c4)CN(C4CCC(c6nc7cccnc7s6)CC4)C5)c3C2=O)C(=O)N1 Degrader C34H32N6O4S GSPT1 P15170 CRBN WO-2023237116-A1 TPD-VI26IK WO2023237116-A1_A45 . Cn1c(C2CCC(NC(=O)c3cc(COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)ccn3)CC2)nc2ccncc21 Degrader C33H31N7O6 GSPT1 P15170 CRBN WO-2023237116-A1 TPD-DVOVFN WO2023244815-A1_101 . C[C@H]1Cc2ccccc2N1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-TTQPC4 WO2023244815-A1_102 . C[C@@H]1Cc2ccccc2N1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-TXH41S Z5000148087 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2,3-dihydroindole-1-carboxamide\; Z5000148087 O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ccccc54)ccc3C2=O)C(=O)N1 Degrader C22H20N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-I13IF6 WO2023244815-A1_104 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ccccc5C4)ccc3C2=O)C(=O)N1 Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-6CS5UR WO2023244815-A1_105 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ccncc54)ccc3C2=O)C(=O)N1 Degrader C21H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-ZT04W1 Z5000154467 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1,3-dihydroisoindole-2-carboxamide\; Z5000154467 O=C1CCC(N2Cc3cc(NC(=O)N4Cc5ccccc5C4)ccc3C2=O)C(=O)N1 Degrader C22H20N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-OCDCES WO2023244815-A1_107 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5ccccc54)ccc3C2=O)C(=O)N1 Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-RSYVTB WO2023244815-A1_108 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ncccc54)ccc3C2=O)C(=O)N1 Degrader C21H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-RONOMT WO2023244815-A1_109 . CC1(c2ccccc2)CN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-8E35JM WO2023244815-A1_110 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cnccc54)ccc3C2=O)C(=O)N1 Degrader C21H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-2VRTN2 Z5000157057 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-phenylazetidine-1-carboxamide\; Z5000157057 O=C1CCC(N2Cc3cc(NC(=O)N4CC(c5ccccc5)C4)ccc3C2=O)C(=O)N1 Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-X8Q4GQ WO2023244815-A1_112 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cccnc54)ccc3C2=O)C(=O)N1 Degrader C21H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-31ODEP WO2023244815-A1_113 . Cc1cc2c(cn1)CCN2C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H21N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-PQS0TU WO2023244815-A1_114 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5ccc(C(F)(F)F)cc54)ccc3C2=O)C(=O)N1 Degrader C24H21F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-VVE5NA WO2023244815-A1_115 . N#Cc1ccc2c(c1)N(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CC2 Degrader C23H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-478N5Y WO2023244815-A1_116 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5ccc(F)cc54)ccc3C2=O)C(=O)N1 Degrader C23H21FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-9GDXH1 WO2023244815-A1_117 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cccc(C(F)(F)F)c54)ccc3C2=O)C(=O)N1 Degrader C23H19F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-92OA6L WO2023244815-A1_118 . Cc1cc(C)c2c(n1)CN(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)C2 Degrader C23H23N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-6E4V06 WO2023244815-A1_119 . CC1CN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c2ccccc21 Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-PEYVLN WO2023244815-A1_120 . CC1CCc2ccccc2N1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-POZLMG WO2023244815-A1_121 . O=C1CCC(N2CC3C=C(NC(=O)N4Cc5cccnc5C4)C=CC3C2=O)C(=O)N=N1 Degrader C21H20N6O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-P9V6WJ WO2023244815-A1_122 . Cc1cccc2c1CCCN2C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-ALAES9 WO2023244815-A1_123 . CC1c2ccccc2N(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1C Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-G7LMVZ WO2023244815-A1_124 . CC1(C)CN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c2ccccc21 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-M0Q4JB WO2023244815-A1_125 . O=C1CCC(N2Cc3cc(NC(=O)N4c5ccccc5CC4CO)ccc3C2=O)C(=O)N1 Degrader C23H22N4O5 CK1α P48729 CRBN WO-2023244815-A1 TPD-AT3RNL WO2023244815-A1_126 . N#Cc1cccc2c1CCCN2C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H21N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-0VO2DC WO2023244815-A1_127 . O=C1CCC(N2Cc3cc(NC(=O)N4CCC(C(F)(F)F)c5ccccc54)ccc3C2=O)C(=O)N1 Degrader C24H21F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-9Q0BWF WO2023244815-A1_128 . C[C@@H]1C[C@H](C)c2ccccc2N1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-QVE9G9 WO2023244815-A1_129 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5ccc(C(F)F)cc54)ccc3C2=O)C(=O)N1 Degrader C24H22F2N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-QQ09VM WO2023244815-A1_130 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ccccc5C4C(F)(F)F)ccc3C2=O)C(=O)N1 Degrader C24H21F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-3K11ZK WO2023244815-A1_131 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5c(F)cccc54)ccc3C2=O)C(=O)N1 Degrader C23H21FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-DFX2DI WO2023244815-A1_132 . CC1(C)Cc2ccccc2N1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-JB2PH1 WO2023244815-A1_134 . COc1cccc2c1CN(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)C2 Degrader C23H22N4O5 CK1α P48729 CRBN WO-2023244815-A1 TPD-0QRY7I WO2023244815-A1_135 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5c4cccc5C(F)(F)F)ccc3C2=O)C(=O)N1 Degrader C23H19F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-MGCKLR WO2023244815-A1_136 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5ccccc5C5(CC5)C4)ccc3C2=O)C(=O)N1 Degrader C25H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-GW3UDS WO2023244815-A1_137 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ccc(Cl)cc54)ccc3C2=O)C(=O)N1 Degrader C22H19ClN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-EYFRXJ WO2023244815-A1_138 . CC1Cc2ccccc2N1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-KPLEG3 WO2023244815-A1_139 . Cc1cccc2c1N(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CCC2 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-CGITZ9 WO2023244815-A1_140 . Cc1ccc2c(c1)CCC[Ni]2C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H24N3NiO4 CK1α P48729 CRBN WO-2023244815-A1 TPD-8OY6VC WO2023244815-A1_141 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5cc(F)ccc54)ccc3C2=O)C(=O)N1 Degrader C23H21FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-TI4KAQ WO2023244815-A1_142 . N#Cc1ccc2c(c1)CCN2C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-0YSDGK WO2023244815-A1_143 . CC1(C)CCN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c2ccccc21 Degrader C25H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-WZRV6Y WO2023244815-A1_144 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5ccncc5C4)ccc3C2=O)C(=O)N1 Degrader C21H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-346CQA WO2023244815-A1_145 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5ncccc54)ccc3C2=O)C(=O)N1 Degrader C22H21N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-AW5RTE WO2023244815-A1_146 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5cccnc54)ccc3C2=O)C(=O)N1 Degrader C22H21N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-2L9V5O WO2023244815-A1_147 . N#Cc1cccc2c1N(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CC2 Degrader C23H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-ANIJ2V WO2023244815-A1_148 . N#Cc1cccc2c1CCN2C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-26LTZI WO2023244815-A1_149 . Cc1ccc2c(c1)N(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CCC2 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-2NTHXP WO2023244815-A1_150 . N#Cc1ccc2c(c1)CCCN2C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H21N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-7ZDBIJ WO2023244815-A1_151 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ccncc5C4)ccc3C2=O)C(=O)N1 Degrader C22H21N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-REDWA7 WO2023244815-A1_152 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cccc(Cl)c54)ccc3C2=O)C(=O)N1 Degrader C22H19ClN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-ACVLL7 WO2023244815-A1_153 . CC1Cc2ccccc2N(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-UUHKON WO2023244815-A1_154 . CC(C)(C)C1Cc2ccccc2N(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C27H30N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-0KK3V7 WO2023244815-A1_155 . CC(C)c1cccc2c1N(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CCC2 Degrader C26H28N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-UR8FVZ WO2023244815-A1_156 . CC1(C)c2ccccc2CCN1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-NPT9QB WO2023244815-A1_157 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5cccc(F)c54)ccc3C2=O)C(=O)N1 Degrader C23H21FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-EQL9Y1 WO2023244815-A1_158 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5cccc(Cl)c54)ccc3C2=O)C(=O)N1 Degrader C23H21ClN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-MQBD4T WO2023244815-A1_159 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5cccc(OC(F)F)c54)ccc3C2=O)C(=O)N1 Degrader C24H22F2N4O5 CK1α P48729 CRBN WO-2023244815-A1 TPD-CP9757 WO2023244815-A1_160 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCc5c4cccc5C(F)(F)F)ccc3C2=O)C(=O)N1 Degrader C24H21F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-3D2H8I WO2023244815-A1_161 . O=C1CCC(N2Cc3cc(NC(=O)N4CC(n5cccn5)Cc5ccccc54)ccc3C2=O)C(=O)N1 Degrader C26H24N6O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-XSU0LU WO2023244815-A1_163 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cccc(F)c54)ccc3C2=O)C(=O)N1 Degrader C22H19FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-BLHRAK WO2023244815-A1_164 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5c(C6CC6)cccc54)ccc3C2=O)C(=O)N1 Degrader C25H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-CUPJYM WO2023244815-A1_165 . CC1(C)Cc2ccccc2N(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C25H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-VVMFUH WO2023244815-A1_166 . CC1Cc2ccccc2C(C)N1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-PHXS1L WO2023244815-A1_167 . C[C@H]1c2ccccc2CN1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-AKR4I6 WO2023244815-A1_168 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5ccc(C(F)F)cc5C4)ccc3C2=O)C(=O)N1 Degrader C23H20F2N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-VL5VWO WO2023244815-A1_169 . O=C1CCC(N2Cc3cc(NC(=O)N4C5C=CC4c4ccccc45)ccc3C2=O)C(=O)N1 Degrader C24H20N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-SN04IW WO2023244815-A1_170 . C[C@@H]1c2ccccc2CN1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-SQLGK7 WO2023244815-A1_171 . Cc1cc2c(cc1C)N(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CC2 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-JSAKTY WO2023244815-A1_172 . C[C@H]1c2ccccc2[C@H](C)N1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-QLSW0C WO2023244815-A1_173 . O=C1CCC(N2Cc3cc(NC(=O)N4CC5CC5c5cc(Br)ccc54)ccc3C2=O)C(=O)N1 Degrader C24H21BrN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-15NZ2A WO2023244815-A1_174 . O=C1CCC(N2Cc3cc(NC(=O)N4C5CCC4c4ccccc45)ccc3C2=O)C(=O)N1 Degrader C24H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-FQVERU WO2023244815-A1_175 . Cc1ccc2c(c1)CN(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)C2 Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-V2WDPL WO2023244815-A1_176 . N#Cc1cccc2c1CCN(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)C2 Degrader C24H21N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-O32M2L WO2023244815-A1_177 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5ccc(Cl)cc5C4)ccc3C2=O)C(=O)N1 Degrader C22H19ClN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-NQVOTI WO2023244815-A1_178 . O=C1CCC(N2Cc3cc(NC(=O)N4CCC5C=C(F)C=CC54)ccc3C2=O)C(=O)N1 Degrader C22H21FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-OY5EH9 WO2023244815-A1_179 . CC(C)(C)c1ccc2c(c1)CN(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CC2 Degrader C27H30N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-GGFGGQ WO2023244815-A1_180 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ccc(F)cc5C4)ccc3C2=O)C(=O)N1 Degrader C23H21FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-ADSXTH WO2023244815-A1_181 . CC(C)C1c2ccccc2CCN1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C26H28N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-4XAKZM WO2023244815-A1_182 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5cccc(Cl)c5C4)ccc3C2=O)C(=O)N1 Degrader C22H19ClN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-YDJP2P WO2023244815-A1_183 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ccc(-c6ccccc6)cc5C4)ccc3C2=O)C(=O)N1 Degrader C29H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-BS293C WO2023244815-A1_184 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5c(F)cccc5C4)ccc3C2=O)C(=O)N1 Degrader C23H21FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-751L9X WO2023244815-A1_185 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cc(C(F)(F)F)ccc54)ccc3C2=O)C(=O)N1 Degrader C23H19F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-IRVNYA WO2023244815-A1_186 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5ccc(F)cc54)ccc3C2=O)C(=O)N1 Degrader C22H19FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-ZILT6C WO2023244815-A1_187 . CC(C)(C)C1CN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c2ccccc21 Degrader C26H28N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-98ZPF1 WO2023244815-A1_188 . O=C1CCC(N2Cc3cc(NC(=O)N4CC5(CCC5)c5ccccc54)ccc3C2=O)C(=O)N1 Degrader C25H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-FMMIT5 WO2023244815-A1_189 . O=C1CCC(N2Cc3cc(NC(=O)N4CC5(CCOCC5)c5ccccc54)ccc3C2=O)C(=O)N1 Degrader C26H26N4O5 CK1α P48729 CRBN WO-2023244815-A1 TPD-I6MDB1 WO2023244815-A1_190 . Cc1ccc2c(c1)N(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CC2 Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-UMFFGO WO2023244815-A1_191 . CC1CN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)Cc2ccccc21 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-WZH0T6 WO2023244815-A1_192 . O=C1CCC(N2Cc3cc(NC(=O)N4CC5(CCCC5)c5ccccc54)ccc3C2=O)C(=O)N1 Degrader C26H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-HCPXAK WO2023244815-A1_193 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cc(F)ccc5C4)ccc3C2=O)C(=O)N1 Degrader C23H21FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-3BUWY9 WO2023244815-A1_194 . CC(C)(C)c1ccc2c(c1)CCN(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)C2 Degrader C27H30N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-5WGLOY WO2023244815-A1_195 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cccnc5C4)ccc3C2=O)C(=O)N1 Degrader C22H21N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-JF7JK8 WO2023244815-A1_196 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5ccccc5C(C(F)(F)F)C4)ccc3C2=O)C(=O)N1 Degrader C24H21F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-HBQJFK SCHEMBL27310929 5-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2,3-dihydroindole-1-carboxamide\; SCHEMBL27310929 O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cc(Cl)ccc54)ccc3C2=O)C(=O)N1 Degrader C22H19ClN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-6LPOQ4 WO2023244815-A1_198 . Cc1cccc2c1CCN2C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-F3SIVY WO2023244815-A1_199 . COc1ccc2c(c1)CN(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)C2 Degrader C23H22N4O5 CK1α P48729 CRBN WO-2023244815-A1 TPD-GT14P1 WO2023244815-A1_200 . CC1(C)CN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)Cc2ccccc21 Degrader C25H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-87YI55 WO2023244815-A1_201 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5c(F)cccc54)ccc3C2=O)C(=O)N1 Degrader C22H19FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-JAHSAT WO2023244815-A1_202 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5cccc(F)c5C4)ccc3C2=O)C(=O)N1 Degrader C22H19FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-O1D2PA WO2023244815-A1_203 . CC(C)C1CN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c2ccccc21 Degrader C25H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-52SLBV WO2023244815-A1_204 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5ccccc5C(F)(F)C4)ccc3C2=O)C(=O)N1 Degrader C23H20F2N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-AYDC6J WO2023244815-A1_205 . CC1Cc2ccccc2CN1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-ZH8E49 WO2023244815-A1_206 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5ccccc5C(n5cccn5)C4)ccc3C2=O)C(=O)N1 Degrader C26H24N6O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-GSJZJD WO2023244815-A1_207 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cnccc5C4)ccc3C2=O)C(=O)N1 Degrader C22H21N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-886DZH WO2023244815-A1_208 . CCC1c2ccccc2CN1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-N0OA8Z WO2023244815-A1_209 . Cc1cc(C)c2c(c1)N(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CC2 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-7AXQCN WO2023244815-A1_210 . O=C1CCC(N2Cc3cc(NC(=O)N4CC5(CC5)c5ccccc54)ccc3C2=O)C(=O)N1 Degrader C24H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-SPVV11 WO2023244815-A1_211 . O=C1CCC(N2Cc3cc(NC(=O)N4CCC5C=CC=CC5C4c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C29H28N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-VTAPF0 WO2023244815-A1_212 . O=C1CCC(N2Cc3cc(NC(=O)N4CCc5cccc(C(F)(F)F)c5C4)ccc3C2=O)C(=O)N1 Degrader C24H21F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-1LJ65R WO2023244815-A1_213 . N#Cc1cccc2c1CN(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)C2 Degrader C23H19N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-1IGZKO WO2023244815-A1_214 . Cc1ccc2c(c1)CCN2C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-IC105E WO2023244815-A1_215 . O=C1CCC(N2Cc3cc(NC(=O)N4Cc5ccccc5CC4c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C29H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-K3PWXN WO2023244815-A1_216 . CC1c2ccccc2CCN1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-I0PPPR WO2023244815-A1_217 . O=C1CCC(N2Cc3cc(NC(=O)N4CC(c5ccccc5F)C4)ccc3C2=O)C(=O)N1 Degrader C23H21FN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-HZNUA8 WO2023244815-A1_218 . O=C1CCC(N2Cc3cc(NC(=O)N4C5CCCC4C5)ccc3C2=O)C(=O)N1 Degrader C20H22N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-4M1YV5 WO2023244815-A1_219 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCCC4C(F)(F)F)ccc3C2=O)C(=O)N1 Degrader C20H21F3N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-GC4NU8 WO2023244815-A1_220 . O=C1CCC(N2Cc3cc(NC(=O)N4CC5[C@H]6CC[C@H](C6)[C@@H]5C4)ccc3C2=O)C(=O)N1 Degrader C23H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-98AMBJ WO2023244815-A1_221 . O=C1CCC(N2Cc3cc(NC(=O)N4CCC5CC54)ccc3C2=O)C(=O)N1 Degrader C19H20N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-1FLIE9 WO2023244815-A1_222 . Cn1cc(C2CCN(C(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)cn1 Degrader C22H24N6O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-XK6H7W WO2023244815-A1_223 . O=C1CCC(N2Cc3cc(NC(=O)N4CCC(c5cnccn5)C4)ccc3C2=O)C(=O)N1 Degrader C22H22N6O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-S1AN2Q WO2023244815-A1_224 . Cc1ccc(C2CCCN2C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cn1 Degrader C24H25N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-D65KZT WO2023244815-A1_225 . Cc1cccc(C2(O)CN(C(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)c1 Degrader C24H24N4O5 CK1α P48729 CRBN WO-2023244815-A1 TPD-8YUBWQ WO2023244815-A1_226 . Cc1cccc(C2CN(C(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)c1 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-LW7IRJ WO2023244815-A1_227 . Cc1ccccc1C1CN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-509IIK WO2023244815-A1_228 . Cc1ccc(C2CN(C(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)cc1 Degrader C24H24N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-I7FYIM WO2023244815-A1_229 . O=C1CCC(N2Cc3cc(NC(=O)N4CCC(c5ncccn5)C4)ccc3C2=O)C(=O)N1 Degrader C22H22N6O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-SF3IRF WO2023244815-A1_230 . O=C1CCC(N2Cc3cc(NC(=O)N4C[C@H]5CC4[C@H](c4ccccc4)C5)ccc3C2=O)C(=O)N1 Degrader C26H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-RY2CA6 WO2023244815-A1_231 . O=C1CCC(N2Cc3cc(NC(=O)N4CC(c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C23H21ClN4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-BURMWE WO2023244815-A1_232 . O=C1CCC(N2Cc3cc(NC(=O)N4CCCCC4C4CC4)ccc3C2=O)C(=O)N1 Degrader C22H26N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-X4B8D4 WO2023244815-A1_233 . CC(C)C1(c2ccccc2)CN(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1 Degrader C26H28N4O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-YLLOZC WO2023244815-A1_234 . O=C1CCC(N2Cc3cc(NC(=O)N4CCN(C56CC(C5)C6)CC4)ccc3C2=O)C(=O)N1 Degrader C23H27N5O4 CK1α P48729 CRBN WO-2023244815-A1 TPD-YSMVP0 WO2023244818-A1_102 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1,3-thiazole-2-carboxamide O=C1CCC(N2Cc3cc(NC(=O)c4nccs4)ccc3C2=O)C(=O)N1 Degrader C17H14N4O4S CK1α P48729 CRBN WO-2023244818-A1 TPD-VKU515 WO2023244818-A1_103 . O=C1CCC(N2Cc3cc(NC(=O)c4ncccc4Cl)ccc3C2=O)C(=O)N1 Degrader C19H15ClN4O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-1ISFE7 WO2023244818-A1_104 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]pyrimidine-2-carboxamide O=C1CCC(N2Cc3cc(NC(=O)c4ncccn4)ccc3C2=O)C(=O)N1 Degrader C18H15N5O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-A1UUW9 WO2023244818-A1_105 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]pyrimidine-4-carboxamide O=C1CCC(N2Cc3cc(NC(=O)c4ccncn4)ccc3C2=O)C(=O)N1 Degrader C18H15N5O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-8VRRVB WO2023244818-A1_106 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1-methylpyrazole-3-carboxamide Cn1ccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)n1 Degrader C18H17N5O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-7IK5FJ WO2023244818-A1_107 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1H-imidazole-2-carboxamide O=C1CCC(N2Cc3cc(NC(=O)c4ncc[nH]4)ccc3C2=O)C(=O)N1 Degrader C17H15N5O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-QCAWUZ WO2023244818-A1_108 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-pyridin-2-ylacetamide O=C1CCC(N2Cc3cc(NC(=O)Cc4ccccn4)ccc3C2=O)C(=O)N1 Degrader C20H18N4O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-JYGSJ0 WO2023244818-A1_109 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1-phenylimidazole-4-carboxamide O=C1CCC(N2Cc3cc(NC(=O)c4cn(-c5ccccc5)cn4)ccc3C2=O)C(=O)N1 Degrader C23H19N5O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-0TGDOO WO2023244818-A1_110 4-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-6-methoxy-1-oxo-3H-isoindol-5-yl]benzamide COc1cc2c(cc1NC(=O)c1ccc(Cl)cc1)CN(C1CCC(=O)NC1=O)C2=O Degrader C21H18ClN3O5 CK1α P48729 CRBN WO-2023244818-A1 TPD-QQ8W0P WO2023244818-A1_111 4-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-6-ethyl-1-oxo-3H-isoindol-5-yl]benzamide CCc1cc2c(cc1NC(=O)c1ccc(Cl)cc1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H20ClN3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-M2P3A3 WO2023244818-A1_112 . O=C1CCC(N2Cc3cc(N(CC(F)(F)F)C(=O)c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 Degrader C22H17ClF3N3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-105MZV WO2023244818-A1_113 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-(2,2,2-trifluoroethyl)benzamide O=C1CCC(N2Cc3cc(NC(=O)c4ccccc4CC(F)(F)F)ccc3C2=O)C(=O)N1 Degrader C22H18F3N3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-R707VA WO2023244818-A1_114 N-[2-(2,6-dioxopiperidin-3-yl)-6-methyl-1-oxo-3H-isoindol-5-yl]benzamide Cc1cc2c(cc1NC(=O)c1ccccc1)CN(C1CCC(=O)NC1=O)C2=O Degrader C21H19N3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-439HW8 WO2023244818-A1_115 . O=C1CCC(N2Cc3cc(NC(=O)c4cnccn4)ccc3C2=O)C(=O)N1 Degrader C18H15N5O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-ECRAM6 WO2023244818-A1_116 2-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]isoindole-1,3-dione O=C1CCC(N2Cc3cc(N4C(=O)c5ccccc5C4=O)ccc3C2=O)C(=O)N1 Degrader C21H15N3O5 CK1α P48729 CRBN WO-2023244818-A1 TPD-PFUGS1 WO2023244818-A1_117 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-phenylcyclobutane-1-carboxamide O=C1CCC(N2Cc3cc(NC(=O)C4CC(c5ccccc5)C4)ccc3C2=O)C(=O)N1 Degrader C24H23N3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-U1V6CX WO2023244818-A1_118 . C=C1NC(=O)CCC1N1Cc2cc(NC(=O)c3ccccc3C#N)ccc2C1=O Degrader C22H18N4O3 CK1α P48729 CRBN WO-2023244818-A1 TPD-JTONGM WO2023244818-A1_119 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1-methylimidazole-2-carboxamide Cn1ccnc1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C18H17N5O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-HQRDTC WO2023244818-A1_120 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1,3-oxazole-2-carboxamide O=C1CCC(N2Cc3cc(NC(=O)c4ncco4)ccc3C2=O)C(=O)N1 Degrader C17H14N4O5 CK1α P48729 CRBN WO-2023244818-A1 TPD-RLDR3J WO2023244818-A1_121 4-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-fluorobenzamide O=C1CCC(N2Cc3cc(NC(=O)c4ccc(Cl)c(F)c4)ccc3C2=O)C(=O)N1 Degrader C20H15ClFN3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-0W3I3I WO2023244818-A1_122 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-(trifluoromethyl)benzamide O=C1CCC(N2Cc3cc(NC(=O)c4ccc(C(F)(F)F)cc4)ccc3C2=O)C(=O)N1 Degrader C21H16F3N3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-DDINO5 WO2023244818-A1_123 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-6-methylpyridine-3-carboxamide Cc1ccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cn1 Degrader C20H18N4O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-SO04KL WO2023244818-A1_124 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-oxo-1,3-dihydroindole-4-carboxamide O=C1CCC(N2Cc3cc(NC(=O)c4cccc5c4CC(=O)N5)ccc3C2=O)C(=O)N1 Degrader C22H18N4O5 CK1α P48729 CRBN WO-2023244818-A1 TPD-BK6DQG WO2023244818-A1_125 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-(trifluoromethyl)benzamide O=C1CCC(N2Cc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C2=O)C(=O)N1 Degrader C21H16F3N3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-OTBBPM WO2023244818-A1_126 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-fluorobenzamide O=C1CCC(N2Cc3cc(NC(=O)c4ccc(F)cc4)ccc3C2=O)C(=O)N1 Degrader C20H16FN3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-XJOOZ0 NSC835958 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-methylbenzamide\; NSC835958; NSC-835958 Cc1ccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C21H19N3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-2O3UUC WO2023244818-A1_128 . O=C1CCC(N2Cc3cc(NC(=O)c4ccccc4C4CCCC4)ccc3C2=O)C(=O)N1 Degrader C25H25N3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-79XJTL WO2023244818-A1_129 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2,3-dihydro-1H-indene-4-carboxamide O=C1CCC(N2Cc3cc(NC(=O)c4cccc5c4CCC5)ccc3C2=O)C(=O)N1 Degrader C23H21N3O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-S863SC WO2023244818-A1_130 4-cyano-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]benzamide N#Cc1ccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C21H16N4O4 CK1α P48729 CRBN WO-2023244818-A1 TPD-WQCYQN WO2023246944-A1_1 . CC1(C(=O)N2CCC(c3ncc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)o3)CC2)CCC1 Degrader C28H31N5O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-0JUP4L WO2023246944-A1_10 . CC1(C(=O)N2CCC(c3ncc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)o3)CC2)CCCCC1 Degrader C30H35N5O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-0FKNQX SCHEMBL29183442 2-(2,6-Dioxopiperidin-3-yl)-4-[[2-[3-(oxetan-3-yloxy)phenyl]-1,3-oxazol-5-yl]methylamino]isoindole-1,3-dione\; SCHEMBL29183442 O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5cccc(OC6COC6)c5)o4)c3C2=O)C(=O)N1 Degrader C26H22N4O7 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-HDO0XL SCHEMBL29183428 2-(2,6-Dioxopiperidin-3-yl)-4-[[2-[2-(oxetan-3-yloxy)phenyl]-1,3-oxazol-5-yl]methylamino]isoindole-1,3-dione\; SCHEMBL29183428 O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccccc5OC5COC5)o4)c3C2=O)C(=O)N1 Degrader C26H22N4O7 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-7RLEZE SCHEMBL29183433 2-(2,6-Dioxopiperidin-3-yl)-4-[[2-[4-(oxetan-3-yloxy)phenyl]-1,3-thiazol-5-yl]methylamino]isoindole-1,3-dione\; SCHEMBL29183433 O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(OC6COC6)cc5)s4)c3C2=O)C(=O)N1 Degrader C26H22N4O6S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-Z5VSAE WO2023246944-A1_103 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(OC6CC6)cc5)s4)c3C2=O)C(=O)N1 Degrader C26H22N4O5S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-0P3G9G SCHEMBL29183421 2-(2,6-Dioxopiperidin-3-yl)-4-[[2-[4-(2-methoxyethoxy)phenyl]-1,3-thiazol-5-yl]methylamino]isoindole-1,3-dione\; SCHEMBL29183421 COCCOc1ccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)s2)cc1 Degrader C26H24N4O6S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-X0EIM0 WO2023246944-A1_105 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc([C@H]5CC[C@@H](Cc6ccc(F)cc6)CC5)o4)c3C2=O)C(=O)N1 Degrader C30H29FN4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-W9L5ZI WO2023246944-A1_106 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc([C@H]5CC[C@H](Cc6ccc(F)cc6)CC5)o4)c3C2=O)C(=O)N1 Degrader C30H29FN4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-S5T74N WO2023246944-A1_11 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(C5CCN(C(=O)CC67CC8CC(CC(C8)C6)C7)CC5)o4)c3C2=O)C(=O)N1 Degrader C34H39N5O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-648XEH WO2023246944-A1_12 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(C5CCN(Cc6ccc(F)cc6)CC5)o4)c3C2=O)C(=O)N1 Degrader C29H28FN5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-CA5S74 WO2023246944-A1_13 . N#Cc1ccc(CN2CCC(c3ncc(CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)o3)CC2)c(F)c1 Degrader C30H27FN6O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-PMLPXL WO2023246944-A1_14 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(C5CCN(Cc6ccc(OC(F)(F)F)cc6)CC5)o4)c3C2=O)C(=O)N1 Degrader C30H28F3N5O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-FMSJUH WO2023246944-A1_15 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(OC(F)(F)F)cc5)o4)c3C2=O)C(=O)N1 Degrader C24H17F3N4O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-8EX2O2 WO2023246944-A1_16 . COc1ccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)o2)cc1 Degrader C24H20N4O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-8PN5C6 WO2023246944-A1_17 . COc1cccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)o2)c1 Degrader C24H20N4O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-SGUJ4P WO2023246944-A1_18 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5cccc(-c6ccccc6)c5)o4)c3C2=O)C(=O)N1 Degrader C29H22N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-MIUKLQ WO2023246944-A1_19 . Cc1ccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)o2)cc1 Degrader C24H20N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-1F4CUS WO2023246944-A1_2 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(C5CCN(C(=O)C6(c7ccc(F)cc7)CCC6)CC5)o4)c3C2=O)C(=O)N1 Degrader C33H32FN5O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-ICRUBE WO2023246944-A1_20 . Cc1cccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)o2)c1 Degrader C24H20N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-B97PN5 WO2023246944-A1_21 . Cc1ccccc1-c1ncc(CNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)o1 Degrader C24H20N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-VQSF6Z WO2023246944-A1_22 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccccc5)o4)c3C2=O)C(=O)N1 Degrader C23H18N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-QBM23F WO2023246944-A1_23 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(Br)cc5)o4)c3C2=O)C(=O)N1 Degrader C23H17BrN4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-7CFULQ WO2023246944-A1_24 . Cc1ccc(-c2cnc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)o2)cc1 Degrader C24H20N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-ZQJZHB WO2023246944-A1_25 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(Cl)cc5)o4)c3C2=O)C(=O)N1 Degrader C23H17ClN4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-28EZ7W SCHEMBL29183407 4-[[2-(2-Chlorophenyl)-1,3-oxazol-5-yl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione\; SCHEMBL29183407 O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccccc5Cl)o4)c3C2=O)C(=O)N1 Degrader C23H17ClN4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-K99G9L WO2023246944-A1_28 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5cccc(F)c5)s4)c3C2=O)C(=O)N1 Degrader C23H17FN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-WDQ5LU WO2023246944-A1_29 . Cc1ccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)s2)cc1 Degrader C24H20N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-U1GRC1 WO2023246944-A1_3 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(C5CCN(C(=O)C67CC8CC(CC(C8)C6)C7)CC5)o4)c3C2=O)C(=O)N1 Degrader C33H37N5O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-W5MKVB WO2023246944-A1_30 . N#Cc1cccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)s2)c1 Degrader C24H17N5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-7F8LET WO2023246944-A1_31 . C=Cc1ccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)s2)cc1 Degrader C25H20N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-1FE4SQ WO2023246944-A1_33 . N#Cc1ccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)s2)cc1 Degrader C24H17N5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-775S35 WO2023246944-A1_34 . O=C1CCC(N2C(=O)c3cccc(NCc4ncc(-c5ccc(F)cc5)s4)c3C2=O)C(=O)N1 Degrader C23H17FN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-8CTGRT WO2023246944-A1_35 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(OC(F)(F)F)cc5)s4)c3C2=O)C(=O)N1 Degrader C24H17F3N4O5S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-QEDN3X WO2023246944-A1_36 . COc1ccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)s2)c(OC)c1 Degrader C25H22N4O6S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-VNMGHY WO2023246944-A1_37 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(C(F)(F)F)cc5)s4)c3C2=O)C(=O)N1 Degrader C24H17F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-5BB8TU WO2023246944-A1_39 . CC(C)(C)C(=O)OCN1C(=O)CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(C(F)(F)F)cc5)s4)c3C2=O)C1=O Degrader C30H27F3N4O6S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-Q1D03S WO2023246944-A1_4 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(C5CCN(C(=O)C6(C(F)(F)F)CCC6)CC5)o4)c3C2=O)C(=O)N1 Degrader C28H28F3N5O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-AC6NGF WO2023246944-A1_40 . CC(C)(C)C(=O)OCN1C(=O)CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(Cl)cc5)o4)c3C2=O)C1=O Degrader C29H27ClN4O7 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-331ZPA WO2023246944-A1_41 . CC(C)(C)C(=O)OCN1C(=O)CCC(N2C(=O)c3cccc(NCc4cnc(C5CCN(C(=O)C(C)(C)C)CC5)o4)c3C2=O)C1=O Degrader C33H41N5O8 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-H80NLZ WO2023246944-A1_42 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(C5CCC(Cc6ccc(F)cc6)CC5)o4)c3C2=O)C(=O)N1 Degrader C30H29FN4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-6JQR97 WO2023246944-A1_43 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(Cl)cn5)s4)c3C2=O)C(=O)N1 Degrader C22H16ClN5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-B88XVF WO2023246944-A1_44 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(Cl)nc5)o4)c3C2=O)C(=O)N1 Degrader C22H16ClN5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-Z6HVHH SCHEMBL29183385 2-(2,6-dioxopiperidin-3-yl)-4-[[2-[4-[(3S)-oxolan-3-yl]oxyphenyl]-1,3-oxazol-5-yl]methylamino]isoindole-1,3-dione\; SCHEMBL29183385 O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(O[C@H]6CCOC6)cc5)o4)c3C2=O)C(=O)N1 Degrader C27H24N4O7 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-UIKWNL WO2023246944-A1_49 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(OC6COC6)cc5)o4)c3C2=O)C(=O)N1 Degrader C26H22N4O7 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-3I21CD WO2023246944-A1_5 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(C5CCN(C(=O)c6ccc(F)cc6)CC5)o4)c3C2=O)C(=O)N1 Degrader C29H26FN5O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-CNDYFL WO2023246944-A1_50 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(OCCO)cc5)o4)c3C2=O)C(=O)N1 Degrader C25H22N4O7 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-0QZP2F WO2023246944-A1_51 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(OC6CC6)cc5)o4)c3C2=O)C(=O)N1 Degrader C26H22N4O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-WKOJAL WO2023246944-A1_52 . COCCOc1ccc(-c2ncc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)o2)cc1 Degrader C26H24N4O7 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-P60Q7W WO2023246944-A1_53 . O=C1CCC(N2C(=O)c3cccc(NCc4cnc(-c5ccc(OC6CCOCC6)cc5)o4)c3C2=O)C(=O)N1 Degrader C28H26N4O7 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023246944-A1 TPD-NSRPL2 SCHEMBL24847420 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(4-ethylphenyl)prop-2-ynamide\; SCHEMBL24847420 CCc1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C25H23N3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-1B33Z9 WO2023274246-A1_10 . O=C(C#Cc1ccc(F)cc1F)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H17F2N3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-DNY38I SCHEMBL24847680 3-(3,5-dichloro-4-hydroxyphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847680 O=C(C#Cc1cc(Cl)c(O)c(Cl)c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H17Cl2N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-NO47Z4 SCHEMBL24847662 3-(3-chloro-4-hydroxyphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847662 O=C(C#Cc1ccc(O)c(Cl)c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H18ClN3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-DXVRKM SCHEMBL24847666 3-(1-benzofuran-5-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847666 O=C(C#Cc1ccc2occc2c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H19N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-OI0Y4F SCHEMBL24847406 3-chloro-4-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxoprop-1-ynyl]benzoic acid\; SCHEMBL24847406 O=C(C#Cc1ccc(C(=O)O)cc1Cl)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H18ClN3O6 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-3D38V9 SCHEMBL24847673 2-chloro-5-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxoprop-1-ynyl]benzoic acid\; SCHEMBL24847673 O=C(C#Cc1ccc(Cl)c(C(=O)O)c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H18ClN3O6 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-KEKXTC SCHEMBL24847663 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(4-hydroxy-2,6-dimethylphenyl)prop-2-ynamide\; SCHEMBL24847663 Cc1cc(O)cc(C)c1C#CC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H23N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-298GID SCHEMBL24847377 3-(1,3-benzothiazol-2-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847377 O=C(C#Cc1nc2ccccc2s1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H18N4O4S GSPT1 P15170 CRBN WO-2023274246-A1 TPD-VE69PZ SCHEMBL24847674 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(1H-indazol-5-yl)prop-2-ynamide\; SCHEMBL24847674 O=C(C#Cc1ccc2[nH]ncc2c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H19N5O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-6MP9CP SCHEMBL24847681 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(1H-indol-5-yl)prop-2-ynamide\; SCHEMBL24847681 O=C(C#Cc1ccc2[nH]ccc2c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H20N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-V8437G SCHEMBL24847689 3-(2-chloro-4-hydroxyphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847689 O=C(C#Cc1ccc(O)cc1Cl)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H18ClN3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-Z3CYZE SCHEMBL24847358 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-phenylprop-2-ynamide\; SCHEMBL24847358 O=C(C#Cc1ccccc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H19N3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-DDOBJR SCHEMBL24847682 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(1H-indol-2-yl)prop-2-ynamide\; SCHEMBL24847682 O=C(C#Cc1cc2ccccc2[nH]1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H20N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-D4HKW2 SCHEMBL24847690 3-cyclopentyl-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847690 O=C(C#CC1CCCC1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H23N3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-3VRYGW SCHEMBL24847691 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(4-hydroxy-2-methylphenyl)prop-2-ynamide\; SCHEMBL24847691 Cc1cc(O)ccc1C#CC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H21N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-HO7WLG SCHEMBL24847409 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(2-hydroxy-3-methylphenyl)prop-2-ynamide\; SCHEMBL24847409 Cc1cccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1O Degrader C24H21N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-DSBLIB SCHEMBL24847683 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(3-hydroxy-2-methylphenyl)prop-2-ynamide\; SCHEMBL24847683 Cc1c(O)cccc1C#CC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H21N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-OVM1WJ SCHEMBL24848580 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-4-hydroxy-4-phenylbut-2-ynamide\; SCHEMBL24848580 O=C(C#CC(O)c1ccccc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H21N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-MVORFI SCHEMBL24847410 3-(2-acetylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847410 CC(=O)c1ccccc1C#CC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H21N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-GFTX4R SCHEMBL24847708 3-(3-acetylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847708 CC(=O)c1cccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1 Degrader C25H21N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-9H0AQO SCHEMBL24848617 3-(4-acetylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24848617 CC(=O)c1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C25H21N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-TR6PXN SCHEMBL24847718 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-1-methyl-3-oxoindene-2-carboxamide\; SCHEMBL24847718 CC1=C(C(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C(=O)c2ccccc21 Degrader C25H21N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-G87VI6 SCHEMBL24847368 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(5-fluoropyridin-2-yl)prop-2-ynamide\; SCHEMBL24847368 O=C(C#Cc1ccc(F)cn1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H17FN4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-S6JQX5 SCHEMBL24847614 3-(1,3-benzothiazol-6-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847614 O=C(C#Cc1ccc2ncsc2c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H18N4O4S GSPT1 P15170 CRBN WO-2023274246-A1 TPD-14J3N0 SCHEMBL24848588 3-(1,3-benzothiazol-5-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24848588 O=C(C#Cc1ccc2scnc2c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H18N4O4S GSPT1 P15170 CRBN WO-2023274246-A1 TPD-JZ0TT8 SCHEMBL24848221 3-(1,3-benzoxazol-6-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24848221 O=C(C#Cc1ccc2ncoc2c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H18N4O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-RB1YWT SCHEMBL24848618 3-(1,3-benzoxazol-5-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24848618 O=C(C#Cc1ccc2ocnc2c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H18N4O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-RVJ5YW SCHEMBL24847357 3-(4-aminophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847357 Nc1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C23H20N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-WS6FIA SCHEMBL24848220 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-4-pyrrolidin-1-ylbut-2-ynamide\; SCHEMBL24848220 O=C(C#CCN1CCCC1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H24N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-57IP9L SCHEMBL24848237 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-pyrrolidin-1-ylprop-2-ynamide\; SCHEMBL24848237 O=C(C#CN1CCCC1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C21H22N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-Q0UAXK SCHEMBL24848202 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-quinazolin-6-ylprop-2-ynamide\; SCHEMBL24848202 O=C(C#Cc1ccc2ncncc2c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H19N5O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-YHDAFD SCHEMBL24848034 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(4-oxo-3H-quinazolin-6-yl)prop-2-ynamide\; SCHEMBL24848034 O=C(C#Cc1ccc2nc[nH]c(=O)c2c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H19N5O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-QT1D2S SCHEMBL24848230 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(6-fluoro-1H-indazol-5-yl)prop-2-ynamide\; SCHEMBL24848230 O=C(C#Cc1cc2cn[nH]c2cc1F)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H18FN5O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-UA38MJ WO2023274246-A1_13 . Cc1cc(F)c(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c(F)c1 Degrader C24H19F2N3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-JTA8NY SCHEMBL24847393 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(4-fluoro-1H-indazol-5-yl)prop-2-ynamide\; SCHEMBL24847393 O=C(C#Cc1ccc2[nH]ncc2c1F)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H18FN5O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-Z5THTG SCHEMBL24848033 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(1-methylbenzimidazol-5-yl)prop-2-ynamide\; SCHEMBL24848033 Cn1cnc2cc(C#CC(=O)NCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)ccc21 Degrader C25H21N5O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-ZB4KMY SCHEMBL24847407 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(3-methylbenzimidazol-5-yl)prop-2-ynamide\; SCHEMBL24847407 Cn1cnc2ccc(C#CC(=O)NCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc21 Degrader C25H21N5O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-BQSAAJ SCHEMBL24848030 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(1-methylbenzimidazol-4-yl)prop-2-ynamide\; SCHEMBL24848030 Cn1cnc2c(C#CC(=O)NCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cccc21 Degrader C25H21N5O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-6FUF7B SCHEMBL24847331 (Z)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-fluoro-3-(3-fluorophenyl)prop-2-enamide\; SCHEMBL24847331 O=C1CCC(N2Cc3cc(CNC(=O)/C(F)=C/c4cccc(F)c4)ccc3C2=O)C(=O)N1 Degrader C23H19F2N3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-QGNFVH SCHEMBL24847418 (E)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-phenylprop-2-enamide\; SCHEMBL24847418 O=C(/C=C/c1ccccc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H21N3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-UR5LBI SCHEMBL24848170 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-pyridin-3-ylprop-2-ynamide\; SCHEMBL24848170 O=C(C#Cc1cccnc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H18N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-3496P0 SCHEMBL24848195 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]pent-2-ynamide\; SCHEMBL24848195 CCC#CC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C19H19N3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-PU2IB5 SCHEMBL24848177 3-(3-bromophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24848177 O=C(C#Cc1cccc(Br)c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H18BrN3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-Z181M2 SCHEMBL24848167 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(3-hydroxyphenyl)prop-2-ynamide\; SCHEMBL24848167 O=C(C#Cc1cccc(O)c1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H19N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-OHJI7D SCHEMBL24847421 3-[4-(2,2-difluoroethyl)phenyl]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847421 O=C(C#Cc1ccc(CC(F)F)cc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H21F2N3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-TJN9QB WO2023274246-A1_20 . C[Si](C)(C)C#CC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C20H23N3O4Si GSPT1 P15170 CRBN WO-2023274246-A1 TPD-5YLYBZ SCHEMBL24848209 4-[tert-butyl(dimethyl)silyl]oxy-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]but-2-ynamide\; SCHEMBL24848209 CC(C)(C)[Si](C)(C)OCC#CC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H31N3O5Si GSPT1 P15170 CRBN WO-2023274246-A1 TPD-NZYH91 SCHEMBL24848176 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-4-hydroxybut-2-ynamide\; SCHEMBL24848176 O=C(C#CCO)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C18H17N3O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-SR4T9C SCHEMBL24848192 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-pyridin-4-ylprop-2-ynamide\; SCHEMBL24848192 O=C(C#Cc1ccncc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H18N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-LO3A9S SCHEMBL24847353 3-(1,3-benzodioxol-5-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847353 O=C(C#Cc1ccc2c(c1)OCO2)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H19N3O6 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-11KEVG SCHEMBL24848165 tert-butyl 4-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxoprop-1-ynyl]benzoate\; SCHEMBL24848165 CC(C)(C)OC(=O)c1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C28H27N3O6 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-3B25EW SCHEMBL24848011 4-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxoprop-1-ynyl]benzoic acid\; SCHEMBL24848011 O=C(C#Cc1ccc(C(=O)O)cc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C24H19N3O6 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-0M4QME SCHEMBL24847667 3-(5-chloropyridin-2-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847667 O=C(C#Cc1ccc(Cl)cn1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H17ClN4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-Y13RFL SCHEMBL24847668 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(5-methylpyridin-2-yl)prop-2-ynamide\; SCHEMBL24847668 Cc1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)nc1 Degrader C23H20N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-Q6BIJG SCHEMBL24848210 ethyl 6-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxoprop-1-ynyl]pyridine-3-carboxylate\; SCHEMBL24848210 CCOC(=O)c1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)nc1 Degrader C25H22N4O6 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-IC3KHJ SCHEMBL24847775 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(4-fluorophenyl)prop-2-ynamide\; SCHEMBL24847775 O=C(C#Cc1ccc(F)cc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H18FN3O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-GLOG5W SCHEMBL24848169 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(5-methoxypyridin-2-yl)prop-2-ynamide\; SCHEMBL24848169 COc1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)nc1 Degrader C23H20N4O5 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-T5P0IR SCHEMBL24848181 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(6-methylpyridin-3-yl)prop-2-ynamide\; SCHEMBL24848181 Cc1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cn1 Degrader C23H20N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-N32UR1 SCHEMBL24847647 [4-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxoprop-1-ynyl]phenyl] acetate\; SCHEMBL24847647 CC(=O)Oc1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C25H21N3O6 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-MBQ46H SCHEMBL24847995 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(1-methylimidazol-4-yl)prop-2-ynamide\; SCHEMBL24847995 Cn1cnc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1 Degrader C21H19N5O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-BDFQ0G SCHEMBL24848183 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-[5-(trifluoromethyl)pyridin-2-yl]prop-2-ynamide\; SCHEMBL24848183 O=C(C#Cc1ccc(C(F)(F)F)cn1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C23H17F3N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-7VTYFO SCHEMBL24848024 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(1-methylpyrazol-3-yl)prop-2-ynamide\; SCHEMBL24848024 Cn1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)n1 Degrader C21H19N5O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-ZS72S0 SCHEMBL24847382 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(5-methylthiophen-2-yl)prop-2-ynamide\; SCHEMBL24847382 Cc1ccc(C#CC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)s1 Degrader C22H19N3O4S GSPT1 P15170 CRBN WO-2023274246-A1 TPD-T7A42Y SCHEMBL24848185 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(6-fluoropyridin-3-yl)prop-2-ynamide\; SCHEMBL24848185 O=C(C#Cc1ccc(F)nc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H17FN4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-JIEAOI SCHEMBL24847699 3-(4,6-dichloropyridin-3-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]prop-2-ynamide\; SCHEMBL24847699 O=C(C#Cc1cnc(Cl)cc1Cl)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H16Cl2N4O4 GSPT1 P15170 CRBN WO-2023274246-A1 TPD-FLK2TH SCHEMBL27109019 3-[6-[(3S)-1-[(2-methylquinazolin-6-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109019 Cc1ncc2cc(CN3CC[C@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)ccc2n1 Degrader C27H27N5O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-1MBVL0 SCHEMBL27109034 3-[3-oxo-5-[(3S)-1-(quinolin-3-ylmethyl)pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109034 O=C1CCC(N2Cc3ccc(O[C@H]4CCN(Cc5cnc6ccccc6c5)C4)cc3C2=O)C(=O)N1 Degrader C27H26N4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-2WWZT5 WO2024006881-A1_100 . CC[C@H]1CC[C@@H](CNc2ncc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)O1 Degrader C33H38N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-76MUSA SCHEMBL27109532 3-[6-[(3S)-1-[[2-[(1S,5R)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl]quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109532 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7[C@@H]8CC[C@H]7COC8)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C32H34N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-Y6YIH3 WO2024006881-A1_102 . O=C1CCC(N2CC3C=C(O[C@H]4CCN(Cc5ccc6nc(N7C[C@H]8C[C@@H](C7)O8)ncc6c5)C4)C=CC3C2=O)C(=O)N1 Degrader C31H34N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-FOT4Z9 SCHEMBL27111703 3-[6-[(3S)-1-[[2-[(1S,5R)-3-oxa-6-azabicyclo[3.1.1]heptan-6-yl]quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27111703 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7[C@@H]8COC[C@H]7C8)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C31H32N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-85M3XW SCHEMBL27111713 3-[6-[(3S)-1-[[2-(1,1-dioxo-1,4-thiazinan-4-yl)quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27111713 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7CCS(=O)(=O)CC7)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C30H32N6O6S WEE1 P30291 CRBN WO-2024006881-A1 TPD-P980CD SCHEMBL27109166 3-[6-[(3S)-1-[[2-(7-oxa-1-azaspiro[3.5]nonan-1-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109166 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7CCC78CCOCC8)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C34H37N5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-ZEIN76 SCHEMBL27109169 3-[6-[(3S)-1-[[2-[(5R)-7-oxa-1-azaspiro[4.4]nonan-1-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109169 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7CCC[C@]78CCOC8)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C34H37N5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-P956WP SCHEMBL27109171 3-[6-[(3S)-1-[[2-[(5S)-7-oxa-1-azaspiro[4.4]nonan-1-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109171 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7CCC[C@@]78CCOC8)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C34H37N5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-0ZWM63 SCHEMBL27111791 3-[6-[(3S)-1-[[2-(6-oxa-1-azaspiro[3.3]heptan-1-yl)quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27111791 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7CCC78COC8)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C31H32N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-7TUMAR SCHEMBL27109172 3-[6-[(3S)-1-[[2-[(5R)-7-oxa-1-azaspiro[4.4]nonan-1-yl]quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109172 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7CCC[C@]78CCOC8)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C33H36N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-1HRFA3 WO2024006881-A1_11 . O=C1CCC(N2CC3=C(C=CC(O[C@H]4CCN(Cc5ccnc6ccccc56)C4)C3)C2=O)C(=O)N1 Degrader C27H28N4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-ACHKJ6 SCHEMBL27109173 3-[6-[(3S)-1-[[2-[(5S)-7-oxa-1-azaspiro[4.4]nonan-1-yl]quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109173 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7CCC[C@@]78CCOC8)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C33H36N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-5YAM42 SCHEMBL27109175 3-[6-[(3S)-1-[[2-[(1R,2R)-2-(methoxymethyl)cyclohexyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109175 COC[C@@H]1CCCC[C@H]1c1ccc2cc(CN3CC[C@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)ccc2n1 Degrader C35H40N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-C5K54V WO2024006881-A1_112 . COC[C@H]1CCCCC1c1ccc2cc(CN3CC[C@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)ccc2n1 Degrader C35H40N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-PAXGKO SCHEMBL27109177 3-[6-[(3S)-1-[[2-[(1S,3R)-3-(methoxymethyl)cyclopentyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109177 COC[C@@H]1CC[C@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C1 Degrader C34H38N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-RVYCUR SCHEMBL27109178 3-[6-[(3S)-1-[[2-[4-(methoxymethyl)cyclohexyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109178; SCHEMBL27115224; SCHEMBL27153793 COC[C@H]1CC[C@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CC1 Degrader C35H40N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-ZOYWIK SCHEMBL27109179 3-[6-[(3S)-1-[[2-[(1S,3S)-3-(methoxymethyl)cyclopentyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109179 COC[C@H]1CC[C@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C1 Degrader C34H38N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-AU8YKC SCHEMBL27109180 3-[6-[(3S)-1-[[2-[(1R,3R)-3-(methoxymethyl)cyclopentyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109180 COC[C@@H]1CC[C@@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C1 Degrader C34H38N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-246I0K SCHEMBL27109181 3-[6-[(3S)-1-[[2-[(1R,3S)-3-(methoxymethyl)cyclopentyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109181 COC[C@H]1CC[C@@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C1 Degrader C34H38N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-A5TT87 SCHEMBL27109182 3-[6-[(3S)-1-[[2-[(1S,3R)-3-(methoxymethyl)cyclohexyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109182 COC[C@@H]1CCC[C@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C1 Degrader C35H40N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-YX4O0O SCHEMBL27109184 3-[6-[(3S)-1-[[2-[(1S,3S)-3-(methoxymethyl)cyclohexyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109184 COC[C@H]1CCC[C@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C1 Degrader C35H40N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-72WOTX SCHEMBL27109035 3-[3-oxo-5-[(3R)-1-(quinolin-3-ylmethyl)pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109035 O=C1CCC(N2Cc3ccc(O[C@@H]4CCN(Cc5cnc6ccccc6c5)C4)cc3C2=O)C(=O)N1 Degrader C27H26N4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-2QYDOZ SCHEMBL27109186 3-[6-[(3S)-1-[[2-[(1R,3R)-3-(methoxymethyl)cyclohexyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109186 COC[C@@H]1CCC[C@@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C1 Degrader C35H40N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-USKVE1 SCHEMBL27109187 3-[6-[(3S)-1-[[2-[(1R,3S)-3-(methoxymethyl)cyclohexyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109187 COC[C@H]1CCC[C@@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C1 Degrader C35H40N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-9D7YJ6 SCHEMBL27109188 3-[6-[(3S)-1-[[2-[(3aS,6aR)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]pyrrol-5-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109188 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7C[C@H]8COC[C@H]8C7)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C33H35N5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-YZLV6P SCHEMBL27109190 3-[6-[(3S)-1-[[2-[(3aR,6aS)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]pyrrol-5-yl]quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109190 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7C[C@H]8COC[C@H]8C7)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C32H34N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-YNG7YJ SCHEMBL27109189 3-[6-[(3S)-1-[[2-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydro-4,7-epoxyisoindol-2-yl]quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109189 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7C[C@@H]8C9CCC(O9)[C@@H]8C7)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C34H36N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-OTQUU6 SCHEMBL27109192 3-[6-[(3S)-1-[[2-[(1S,2R)-2-methoxycyclopentyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109192 CO[C@@H]1CCC[C@H]1c1ccc2cc(CN3CC[C@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)ccc2n1 Degrader C33H36N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-W30YIP SCHEMBL27109193 3-[6-[(3S)-1-[[2-[(1R,2S)-2-methoxycyclopentyl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109193 CO[C@H]1CCC[C@@H]1c1ccc2cc(CN3CC[C@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)ccc2n1 Degrader C33H36N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-1616SS SCHEMBL27109194 3-[6-[(3S,4R)-4-methyl-1-[[2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109194 C[C@@H]1CN(Cc2ccc3nc(C4CCOCC4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C33H36N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-91BYXN SCHEMBL27109195 3-[6-[(3S,4R)-1-[[2-(oxan-4-yl)quinolin-6-yl]methyl]-4-(trifluoromethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109195 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc(C7CCOCC7)ccc6c5)C[C@H]4C(F)(F)F)ccc3C2=O)C(=O)N1 Degrader C33H33F3N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-2J2PEA SCHEMBL27109197 (3S)-3-[3-oxo-6-[(3S)-1-[[2-[(3S)-oxolan-3-yl]quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109197 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc([C@@H]7CCOC7)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C30H31N5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-GKEHMA SCHEMBL27109036 3-[3-oxo-6-[[(3R)-1-(quinolin-3-ylmethyl)pyrrolidin-3-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109036 O=C1CCC(N2Cc3cc(C[C@@H]4CCN(Cc5cnc6ccccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C28H28N4O3 WEE1 P30291 CRBN WO-2024006881-A1 TPD-C7K5BA SCHEMBL27109198 (3S)-3-[6-[(3S)-1-[[5-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109198 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(C7CCOCC7)ccc6c5F)C4)ccc3C2=O)C(=O)N1 Degrader C32H33FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-RWAWOZ SCHEMBL27108902 (3S)-3-[6-[(3S)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27108902 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(F)c6nc(C7CCOCC7)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C32H33FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-W3ANLG SCHEMBL27109200 3-[6-[(3S)-1-[[2-[(2R,6S)-2,6-dimethyloxan-4-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109200 C[C@@H]1CC(c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C[C@H](C)O1 Degrader C34H38N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-QT418E SCHEMBL27109202 3-[6-[(3R,4R)-4-fluoro-1-[[2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109202 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc(C7CCOCC7)ccc6c5)C[C@H]4F)ccc3C2=O)C(=O)N1 Degrader C32H33FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-RGJVV8 SCHEMBL27109204 3-[6-[(3S)-1-[[2-[(2R,6R)-2,6-dimethyloxan-4-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109204 C[C@@H]1CC(c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)C[C@@H](C)O1 Degrader C34H38N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-2V9KA4 SCHEMBL27109206 3-[6-[(3S)-1-[[2-[(2R)-2-methyloxan-4-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109206 C[C@@H]1CC(c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CCO1 Degrader C33H36N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-Y0X3SV SCHEMBL27109207 3-[6-[(3S)-1-[[2-[(2S)-2-methyloxan-4-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109207 C[C@H]1CC(c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CCO1 Degrader C33H36N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-R1LI5P SCHEMBL27109208 3-[6-[(3R,4R)-4-methoxy-1-[[2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109208 CO[C@@H]1CN(Cc2ccc3nc(C4CCOCC4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C33H36N4O6 WEE1 P30291 CRBN WO-2024006881-A1 TPD-UGTNLZ SCHEMBL27109209 3-[6-[(3S,4R)-4-methyl-1-[[2-[(3R)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109209 C[C@@H]1CN(Cc2ccc3nc([C@H]4CCOC4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C32H34N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-VNVT4O SCHEMBL27109210 3-[3-oxo-6-[(3S,4R)-1-[[2-[(3R)-oxolan-3-yl]quinolin-6-yl]methyl]-4-(trifluoromethyl)pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109210 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc([C@H]7CCOC7)ccc6c5)C[C@H]4C(F)(F)F)ccc3C2=O)C(=O)N1 Degrader C32H31F3N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-0VW1UG SCHEMBL27109038 2-(2,6-dioxopiperidin-3-yl)-5-[(3S)-1-(quinolin-6-ylmethyl)pyrrolidin-3-yl]oxyisoindole-1,3-dione\; SCHEMBL27109038 O=C1CCC(N2C(=O)c3ccc(O[C@H]4CCN(Cc5ccc6ncccc6c5)C4)cc3C2=O)C(=O)N1 Degrader C27H24N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-UTUX9M SCHEMBL27109211 3-[6-[(3R)-4,4-difluoro-1-[[2-[(3R)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109211 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc([C@H]7CCOC7)ccc6c5)CC4(F)F)ccc3C2=O)C(=O)N1 Degrader C31H30F2N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-JXOLJS SCHEMBL27109213 3-[6-[(3R,4R)-4-fluoro-1-[[2-[(3R)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109213 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc([C@H]7CCOC7)ccc6c5)C[C@H]4F)ccc3C2=O)C(=O)N1 Degrader C31H31FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-V8G00Z SCHEMBL27109214 3-[6-[(3R,4S)-4-fluoro-1-[[2-[(3R)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109214 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc([C@H]7CCOC7)ccc6c5)C[C@@H]4F)ccc3C2=O)C(=O)N1 Degrader C31H31FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-0YNUIE SCHEMBL27109215 3-[6-[(3S,4R)-1-[[8-fluoro-2-[(3R)-oxolan-3-yl]quinolin-6-yl]methyl]-4-methylpyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109215 C[C@@H]1CN(Cc2cc(F)c3nc([C@H]4CCOC4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C32H33FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-GV4KDH SCHEMBL27109217 6-[[(4R)-4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxy]-3,3-difluoropyrrolidin-1-yl]methyl]quinoline-2-carbonitrile\; SCHEMBL27109217 N#Cc1ccc2cc(CN3C[C@@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C(F)(F)C3)ccc2n1 Degrader C28H23F2N5O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-N0KLUM SCHEMBL27109218 6-[[(3R,4R)-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxy]-4-fluoropyrrolidin-1-yl]methyl]quinoline-2-carbonitrile\; SCHEMBL27109218 N#Cc1ccc2cc(CN3C[C@@H](F)[C@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)ccc2n1 Degrader C28H24FN5O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-0SWQLE SCHEMBL27109219 6-[[(3R,4S)-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxy]-4-fluoropyrrolidin-1-yl]methyl]quinoline-2-carbonitrile\; SCHEMBL27109219 N#Cc1ccc2cc(CN3C[C@H](F)[C@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)ccc2n1 Degrader C28H24FN5O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-BXMW7G SCHEMBL27109220 3-[6-[(3S,4R)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]-4-methylpyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109220 C[C@@H]1CN(Cc2cc(F)c3nc(C4CCOCC4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C33H35FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-A2FKCH SCHEMBL27109221 3-[6-[(3R,4S)-4-fluoro-1-[[2-[(3S)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109221 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc([C@@H]7CCOC7)ccc6c5)C[C@@H]4F)ccc3C2=O)C(=O)N1 Degrader C31H31FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-TR9XMU SCHEMBL27109223 3-[6-[(3R,4R)-4-fluoro-1-[[2-[(3S)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109223 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc([C@@H]7CCOC7)ccc6c5)C[C@H]4F)ccc3C2=O)C(=O)N1 Degrader C31H31FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-TC3RYO SCHEMBL27109039 3-[6-[(3S)-1-[(5-fluoroquinolin-3-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109039 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5cnc6cccc(F)c6c5)C4)ccc3C2=O)C(=O)N1 Degrader C27H25FN4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-DTUZ41 SCHEMBL27109224 3-[6-[(3S)-1-[[2-(oxan-4-yl)quinolin-6-yl]methyl]-2-oxopyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109224 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(C7CCOCC7)ccc6c5)C4=O)ccc3C2=O)C(=O)N1 Degrader C32H32N4O6 WEE1 P30291 CRBN WO-2024006881-A1 TPD-TJTWBO SCHEMBL27109225 (3S)-3-[6-[(3S)-1-[[8-fluoro-2-(oxan-4-yl)quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109225 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(F)c6nc(C7CCOCC7)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C31H32FN5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-E0HJA7 SCHEMBL27109227 (3S)-3-[6-[(3S)-1-[[5-fluoro-2-(oxan-4-yl)quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109227 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(C7CCOCC7)ncc6c5F)C4)ccc3C2=O)C(=O)N1 Degrader C31H32FN5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-SIBTYF SCHEMBL27109230 (3S)-3-[6-[(3S)-1-[(8-chloro-2-morpholin-4-ylquinazolin-6-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109230 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(Cl)c6nc(N7CCOCC7)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C30H31ClN6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-U9FRB0 SCHEMBL27109234 3-[6-[(3S,4R)-4-methyl-1-[[2-[(3S)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109234 C[C@@H]1CN(Cc2ccc3nc([C@@H]4CCOC4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C32H34N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-MVN0ZI SCHEMBL27109235 3-[6-[(3R)-4,4-difluoro-1-[[2-[(3S)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109235 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc([C@@H]7CCOC7)ccc6c5)CC4(F)F)ccc3C2=O)C(=O)N1 Degrader C31H30F2N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-8GYIIP SCHEMBL27109240 (3S)-3-[6-[(3S)-1-[(7-fluoro-2-morpholin-4-ylquinazolin-6-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109240 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc6cnc(N7CCOCC7)nc6cc5F)C4)ccc3C2=O)C(=O)N1 Degrader C30H31FN6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-F721RM SCHEMBL27109242 (3S)-3-[6-[(3S)-1-[(8-cyclopropyl-2-morpholin-4-ylquinazolin-6-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109242 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(C6CC6)c6nc(N7CCOCC7)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C33H36N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-3WIL5J SCHEMBL27109245 (3S)-3-[6-[(3S)-1-[[8-cyclopropyl-2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109245 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(C6CC6)c6nc(C7CCOCC7)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C35H38N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-0F1F45 SCHEMBL27109041 3-[6-[(3S)-1-[(1-methylisoquinolin-3-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109041 Cc1nc(CN2CC[C@H](Oc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)cc2ccccc12 Degrader C28H28N4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-ZEHKDH SCHEMBL27109248 3-[3-oxo-6-[(3S,4R)-1-[[2-[(3S)-oxolan-3-yl]quinolin-6-yl]methyl]-4-(trifluoromethyl)pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109248 O=C1CCC(N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc([C@@H]7CCOC7)ccc6c5)C[C@H]4C(F)(F)F)ccc3C2=O)C(=O)N1 Degrader C32H31F3N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-VVKBAY SCHEMBL27109249 (3R)-3-[6-[(3S)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109249 O=C1CC[C@@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(F)c6nc(C7CCOCC7)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C32H33FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-LMGUXS SCHEMBL27109252 (3S)-3-[6-[(3S)-1-[[8-(azetidin-1-yl)-2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109252 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(N6CCC6)c6nc(C7CCOCC7)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C35H39N5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-NJW1C2 SCHEMBL27109255 3-[6-[(3S)-1-[[2-[4-(methylamino)piperidin-1-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109255 CNC1CCN(c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CC1 Degrader C33H38N6O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-SH3GTR SCHEMBL27109259 3-[6-[(3S)-1-[[2-[4-(dimethylamino)piperidin-1-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109259 CN(C)C1CCN(c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CC1 Degrader C34H40N6O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-3QGH3E SCHEMBL27109261 (3S)-3-[6-[(3S)-1-[[2-(4-methylpiperazin-1-yl)quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109261 CN1CCN(c2ncc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN([C@H]5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CC1 Degrader C31H35N7O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-KT6E4K SCHEMBL27109263 (3S)-3-[6-[(3S)-1-[[2-(azetidin-1-yl)quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109263 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7CCC7)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C29H30N6O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-DRLH2L SCHEMBL27109264 3-[3-oxo-6-[(3S)-1-[(2-pyrrolidin-1-ylquinazolin-6-yl)methyl]pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109264 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ccc6nc(N7CCCC7)ncc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C30H32N6O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-FKCO4Q SCHEMBL27109265 (3S)-3-[6-[(3S)-1-[[2-(4-acetylpiperazin-1-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109265 CC(=O)N1CCN(c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN([C@H]5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CC1 Degrader C33H36N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-WOWZK5 SCHEMBL27109266 (3S)-3-[6-[(3S)-1-[[2-(1-acetylpiperidin-4-yl)quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109266 CC(=O)N1CCC(c2ncc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN([C@H]5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CC1 Degrader C33H36N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-04MX4Q SCHEMBL27109044 3-[6-[(3S)-1-[(7-fluoroisoquinolin-3-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109044 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5cc6ccc(F)cc6cn5)C4)ccc3C2=O)C(=O)N1 Degrader C27H25FN4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-OER9NL SCHEMBL27109267 (3S)-3-[6-[(3S)-1-[[2-(1-acetylpiperidin-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109267 CC(=O)N1CCC(c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN([C@H]5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CC1 Degrader C34H37N5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-BKMHOP SCHEMBL27109268 (3S)-3-[6-[(3S)-1-[(8-fluoro-2-morpholin-4-ylquinolin-6-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109268 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(F)c6nc(N7CCOCC7)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C31H32FN5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-EXLGIH SCHEMBL27109270 (3S)-3-[6-[(3S)-1-[[8-fluoro-2-[(3R)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109270 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(F)c6nc([C@H]7CCOC7)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C31H31FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-WAPPKD SCHEMBL27109271 (3S)-3-[6-[(3S)-1-[[8-fluoro-2-[(3S)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109271 O=C1CC[C@H](N2Cc3cc(O[C@H]4CCN(Cc5cc(F)c6nc([C@@H]7CCOC7)ccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C31H31FN4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-2UNSOK WO2024006881-A1_174 . O=C1CC[C@H](N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc(C7CCOC7)ccc6c5)CC4(F)F)ccc3C2=O)C(=O)N1 Degrader C31H30F2N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-RP2688 SCHEMBL27109273 (3S)-3-[6-[(3R)-4,4-difluoro-1-[[2-[(3R)-oxolan-3-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109273 O=C1CC[C@H](N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc([C@H]7CCOC7)ccc6c5)CC4(F)F)ccc3C2=O)C(=O)N1 Degrader C31H30F2N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-P84I2F SCHEMBL27109274 (3S)-3-[6-[(3S)-1-[[2-[(4S)-2,2-dimethyloxan-4-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109274 CC1(C)C[C@@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN([C@H]5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CCO1 Degrader C34H38N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-K95TH9 SCHEMBL27109275 (3S)-3-[6-[(3S)-1-[[2-[(4R)-2,2-dimethyloxan-4-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109275 CC1(C)C[C@H](c2ccc3cc(CN4CC[C@H](Oc5ccc6c(c5)CN([C@H]5CCC(=O)NC5=O)C6=O)C4)ccc3n2)CCO1 Degrader C34H38N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-DIERAX SCHEMBL27109276 (3S)-3-[6-[(3S,4S)-1-[[2-[(4S)-2,2-dimethyloxan-4-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109276 COC[C@@H]1CN(Cc2ccc3nc([C@H]4CCOC(C)(C)C4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN([C@H]1CCC(=O)NC1=O)C2=O Degrader C36H42N4O6 WEE1 P30291 CRBN WO-2024006881-A1 TPD-2LHL7E SCHEMBL27109278 (3S)-3-[6-[(3S,4S)-1-[[2-[(4R)-2,2-dimethyloxan-4-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109278 COC[C@@H]1CN(Cc2ccc3nc([C@@H]4CCOC(C)(C)C4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN([C@H]1CCC(=O)NC1=O)C2=O Degrader C36H42N4O6 WEE1 P30291 CRBN WO-2024006881-A1 TPD-PJYHNZ SCHEMBL27109045 3-[5-[(3S)-1-[(2-methylquinolin-3-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109045 Cc1nc2ccccc2cc1CN1CC[C@H](Oc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)C1 Degrader C28H28N4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-KFPD7Z SCHEMBL27109279 (3S)-3-[6-[(3R)-4,4-difluoro-1-[[7-(oxan-4-yl)isoquinolin-3-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109279 O=C1CC[C@H](N2Cc3cc(O[C@@H]4CN(Cc5cc6ccc(C7CCOCC7)cc6cn5)CC4(F)F)ccc3C2=O)C(=O)N1 Degrader C32H32F2N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-9OWLHM SCHEMBL27109280 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[(2-morpholin-4-ylquinazolin-6-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109280 COC[C@@H]1CN(Cc2ccc3nc(N4CCOCC4)ncc3c2)C[C@H]1Oc1ccc2c(c1)CN([C@H]1CCC(=O)NC1=O)C2=O Degrader C32H36N6O6 WEE1 P30291 CRBN WO-2024006881-A1 TPD-DN2TAI SCHEMBL27109283 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[2-(oxan-4-yl)quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109283 COC[C@@H]1CN(Cc2ccc3nc(C4CCOCC4)ncc3c2)C[C@H]1Oc1ccc2c(c1)CN([C@H]1CCC(=O)NC1=O)C2=O Degrader C33H37N5O6 WEE1 P30291 CRBN WO-2024006881-A1 TPD-GP6Y72 SCHEMBL27109284 (3S)-3-[6-[(3R)-4,4-difluoro-1-[(2-morpholin-4-ylquinazolin-6-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109284 O=C1CC[C@H](N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc(N7CCOCC7)ncc6c5)CC4(F)F)ccc3C2=O)C(=O)N1 Degrader C30H30F2N6O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-JJ6UFX SCHEMBL27109285 (3S)-3-[6-[(3R)-4,4-difluoro-1-[[2-(oxan-4-yl)quinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109285 O=C1CC[C@H](N2Cc3cc(O[C@@H]4CN(Cc5ccc6nc(C7CCOCC7)ncc6c5)CC4(F)F)ccc3C2=O)C(=O)N1 Degrader C31H31F2N5O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-LSIR6K SCHEMBL27109286 (3S)-3-[6-[(3S,4S)-1-[[2-[(4S)-2,2-dimethyloxan-4-yl]-8-fluoroquinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109286 COC[C@@H]1CN(Cc2cc(F)c3nc([C@H]4CCOC(C)(C)C4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN([C@H]1CCC(=O)NC1=O)C2=O Degrader C36H41FN4O6 WEE1 P30291 CRBN WO-2024006881-A1 TPD-SR7F2V SCHEMBL27109287 (3S)-3-[6-[(3S,4S)-1-[[2-(4-acetylpiperazin-1-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109287 COC[C@@H]1CN(Cc2ccc3nc(N4CCN(C(C)=O)CC4)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN([C@H]1CCC(=O)NC1=O)C2=O Degrader C35H40N6O6 WEE1 P30291 CRBN WO-2024006881-A1 TPD-CIFGJP SCHEMBL27109289 3-[3-oxo-6-[(3S)-1-[[7-[(3R)-oxolan-3-yl]isoquinolin-3-yl]methyl]pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109289 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5cc6ccc([C@H]7CCOC7)cc6cn5)C4)ccc3C2=O)C(=O)N1 Degrader C31H32N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-0NWPM0 SCHEMBL27109290 3-[6-[(3S)-1-[(4-methyl-3-oxo-1,4-benzoxazin-6-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109290 CN1C(=O)COc2ccc(CN3CC[C@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)cc21 Degrader C27H28N4O6 WEE1 P30291 CRBN WO-2024006881-A1 TPD-L3O0ZL SCHEMBL27109294 3-[6-[(3S)-1-[[2-(methoxymethyl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109294 COCc1ccc2cc(CN3CC[C@H](Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)ccc2n1 Degrader C29H30N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-A7WC7M SCHEMBL27109048 3-[3-oxo-6-[(3S)-1-(quinazolin-2-ylmethyl)pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109048 O=C1CCC(N2Cc3cc(O[C@H]4CCN(Cc5ncc6ccccc6n5)C4)ccc3C2=O)C(=O)N1 Degrader C26H25N5O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-AWUKRK SCHEMBL27109297 3-[3-oxo-6-[(3R)-1-pyrazin-2-ylpyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109297 O=C1CCC(N2Cc3cc(O[C@@H]4CCN(c5cnccn5)C4)ccc3C2=O)C(=O)N1 Degrader C21H21N5O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-QOPR19 SCHEMBL27109299 2-(2,6-dioxopiperidin-3-yl)-5-[(3R)-1-(quinolin-5-ylmethyl)pyrrolidin-3-yl]oxyisoindole-1,3-dione\; SCHEMBL27109299 O=C1CCC(N2C(=O)c3ccc(O[C@@H]4CCN(Cc5cccc6ncccc56)C4)cc3C2=O)C(=O)N1 Degrader C27H24N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-BR02SS SCHEMBL27109300 2-(2,6-dioxopiperidin-3-yl)-5-[(3R)-1-(quinolin-4-ylmethyl)pyrrolidin-3-yl]oxyisoindole-1,3-dione\; SCHEMBL27109300 O=C1CCC(N2C(=O)c3ccc(O[C@@H]4CCN(Cc5ccnc6ccccc56)C4)cc3C2=O)C(=O)N1 Degrader C27H24N4O5 WEE1 P30291 CRBN WO-2024006881-A1 TPD-I04T19 SCHEMBL27112671 3-[3-oxo-6-[(3R)-1-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27112671 O=C1CCC(N2Cc3cc(O[C@@H]4CCN(Cc5c[nH]c6ncccc56)C4)ccc3C2=O)C(=O)N1 Degrader C25H25N5O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-L309YQ SCHEMBL27112678 3-[3-oxo-6-[(3R)-1-(quinolin-6-ylmethyl)pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27112678 O=C1CCC(N2Cc3cc(O[C@@H]4CCN(Cc5ccc6ncccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C27H26N4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-ACXZS0 SCHEMBL27109613 3-[3-oxo-6-[(3R)-1-(quinolin-4-ylmethyl)pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109613 O=C1CCC(N2Cc3cc(O[C@@H]4CCN(Cc5ccnc6ccccc56)C4)ccc3C2=O)C(=O)N1 Degrader C27H26N4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-KP14TL SCHEMBL27109302 3-[3-oxo-6-[(3R)-1-(quinolin-3-ylmethyl)pyrrolidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27109302 O=C1CCC(N2Cc3cc(O[C@@H]4CCN(Cc5cnc6ccccc6c5)C4)ccc3C2=O)C(=O)N1 Degrader C27H26N4O4 WEE1 P30291 CRBN WO-2024006881-A1 TPD-JOO5E7 WO2024015618-A2_1 . Cc1ccc(C(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C21H17N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-BEV4RO NSC835959 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-methoxybenzamide\; NSC835959; NSC-835959 COc1cccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1 Degrader C21H19N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-3BLCKD WO2024015618-A2_13 . O=C1CCC(N2Cc3cc(NC(=O)c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 Degrader C20H16ClN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-J6ESX9 WO2024015618-A2_16 . O=C1CCC(N2Cc3cc(C(=O)Nc4ccc(F)cc4)ccc3C2=O)C(=O)N1 Degrader C20H16FN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-T0PJF3 WO2024015618-A2_17 . Cc1ccc(NC(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C21H20N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-F6GS1A WO2024015618-A2_18 . CN(C(=O)c1ccccc1)c1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C21H19N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-VEZEDD WO2024015618-A2_19 . Cc1ccc2c(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)noc2c1 Degrader C21H18N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-MTG6E2 WO2024015618-A2_21 . O=C1CCC(N2Cc3cc(NC(=O)c4ccc(-c5ccn[nH]5)cc4)ccc3C2=O)C(=O)N1 Degrader C23H19N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-M7J39M WO2024015618-A2_22 . CC(C)(O)c1ccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C23H23N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-P8IRJ1 WO2024015618-A2_23 . O=C1CCC(N2Cc3cc(NC(=O)c4ccccc4Oc4ccccc4)ccc3C2=O)C(=O)N1 Degrader C26H21N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-7P5SKL WO2024015618-A2_24 . O=C1CCC(N2Cc3cc(NC(=O)Cc4ccc(O)cc4)ccc3C2=O)C(=O)N1 Degrader C21H19N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-PQBOKN WO2024015618-A2_25 . O=C1CCC(N2Cc3cc(NC(=O)Cc4ccccc4Br)ccc3C2=O)C(=O)N1 Degrader C21H18BrN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-A9MP3H WO2024015618-A2_26 . O=C1CCC(N2Cc3cc(NC(=O)c4[nH]c5ccccc5c4Cl)ccc3C2=O)C(=O)N1 Degrader C22H17ClN4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-JZ96R6 WO2024015618-A2_27 . O=C1CCC(N2Cc3cc(NC(=O)c4ccc5nc[nH]c5c4)ccc3C2=O)C(=O)N1 Degrader C21H17N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-1LIXGL WO2024015618-A2_29 . CC(N)c1ccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C22H22N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-QXVP33 WO2024015618-A2_30 . NC1(c2ccc(C(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc2)CCC1 Degrader C24H24N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-YTXJYB WO2024015618-A2_31 . CN1CCN(Cc2ccc(C(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc2)CC1 Degrader C26H29N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-4PTZAL WO2024015618-A2_32 . O=C1CCC(N2Cc3cc(NC(=O)c4ccc(CN5CCOCC5)cc4)ccc3C2=O)C(=O)N1 Degrader C25H26N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-CNRHSB WO2024015618-A2_34 . COc1ccccc1C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C21H19N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-4HNJ64 WO2024015618-A2_35 . Cc1cccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)n1 Degrader C20H18N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-6R8P7U WO2024015618-A2_36 . Cc1ccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)nc1 Degrader C20H18N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-K7B65B WO2024015618-A2_39 . O=C1CCC(N2Cc3cc(NC(=O)c4ccccc4Cl)ccc3C2=O)C(=O)N=N1 Degrader C20H15ClN4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-YA3EF5 WO2024015618-A2_40 . COc1ccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C21H19N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-3HKZES WO2024015618-A2_41 . CC(C)c1cccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1 Degrader C23H23N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024015618-A2 TPD-JXAHU5 WO2024032689-A1_GT-03355 3-[6-[[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-Q3RWB8 WO2024032689-A1_GT-03356 3-[6-[4-[[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]methyl]phenyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(-c4ccc(CN5CCN(Cc6ccccc6-c6ccc(Cl)cc6)CC5)cc4)ccc3C2=O)C(=O)N1 Degrader C37H35ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-Q72RME WO2024032689-A1_GT-03361 3-[6-[[1-[[2-(4-chlorophenyl)phenyl]methyl]piperidin-4-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CC4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C32H32ClN3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-2FTRSX WO2024032689-A1_GT-03367 3-[6-[4-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]phenyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3ccc(-c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)cc3)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C39H43ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-SJ10PE WO2024032689-A1_GT-03368 3-[6-[[1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperidin-4-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C34H40ClN3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-X4U6QP WO2024032689-A1_GT-03454 3-[6-[[4-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C33H39FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-1VH741 WO2024032689-A1_GT-03455 3-[6-[[1-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperidin-4-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C34H40FN3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-M6062I WO2024032689-A1_GT-03468 3-[6-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3ccc4c(c3F)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H38ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-7I684R WO2024032689-A1_GT-03469 3-[6-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3cc(F)c4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H38ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-5BFKTT WO2024032689-A1_GT-03492 3-[6-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H39ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-MX2F3G WO2024032689-A1_GT-03493 3-[6-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CC(C2)N3Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H38ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-AH1YFV WO2024032689-A1_GT-03578 3-[6-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3cc4c(cc3F)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H38ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-Q5PJ9S WO2024032689-A1_GT-03649 3-[7-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H39ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-XCIBNA WO2024032689-A1_GT-03694 3-[6-[[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)c3F)C2=O)C(=O)N1 Degrader C31H30ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-DGWKLG WO2024032689-A1_GT-03695 3-[6-[[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C31H30ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-C9TM5Y WO2024032689-A1_GT-03696 3-[6-[[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C31H30ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-SSWEO8 WO2024032689-A1_GT-03876 3-[7-[[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)cccc3C2=O)C(=O)N1 Degrader C31H31ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-JVG0AA WO2024032689-A1_GT-03877 3-[6-[[1-[[2-(4-chlorophenyl)phenyl]methyl]piperidin-4-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(NC4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-7GVWBS WO2024032689-A1_GT-03878 3-[6-[3-[[2-(4-chlorophenyl)phenyl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(N4C5CCC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 Degrader C32H31ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-G7JECQ WO2024032689-A1_GT-03880 3-[6-[[1-[[2-(4-chlorophenyl)phenyl]methyl]-3-hydroxyazetidin-3-yl]-hydroxymethyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(O)C4(O)CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H28ClN3O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-VE6AAW WO2024032689-A1_GT-03881 . O=C1CCC(N2Cc3cc(C=C4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H26ClN3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-OJCTY9 WO2024032689-A1_GT-03887 3-[6-[[(1R,4R)-5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C[C@H]3C[C@@H]2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H39ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-JV1ITV WO2024032689-A1_GT-03888 3-[6-[[(1R,4R)-5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C[C@H]3C[C@@H]2CN3Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H38ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-FC1M70 WO2024032689-A1_GT-03889 3-[6-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H41ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-B6APB0 WO2024032689-A1_GT-03890 3-[6-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H40ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-5JZSFX WO2024032689-A1_GT-03891 3-[6-[[4-[2-(4-chlorophenyl)benzoyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H29ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-NJVL07 WO2024032689-A1_GT-03922 3-[6-[[1-[2-(4-chlorophenyl)benzoyl]azetidin-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CC4CN(C(=O)c5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H26ClN3O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-UCVYED WO2024032689-A1_GT-03923 3-[6-[[1-[[2-(4-chlorophenyl)phenyl]methyl]azetidin-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CC4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H28ClN3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-TEG7D2 WO2024032689-A1_GT-03991 3-[6-[[4-[2-(4-chlorophenyl)anilino]piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCC(Nc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-39QOSO WO2024032689-A1_GT-03995 3-[6-[[6-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C3CC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C34H39ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-L0WNI6 WO2024032689-A1_GT-03996 3-[6-[[8-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C3CCC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C35H41ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-II8UOT WO2024032689-A1_GT-03997 3-[6-[[(1S,4S)-5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C[C@@H]3C[C@H]2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H39ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-TMSBGS WO2024032689-A1_GT-04167 3-[6-[[5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H41ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-XMVBW7 WO2024032689-A1_GT-04168 3-[6-[[5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC2CN3Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H40ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-H750GN WO2024032689-A1_GT-04169 . O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(=O)c4ccccc4-c4ccc(F)cc4)C5)ccc3C2=O)C(=O)N1 Degrader C32H29FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-7FXJQH WO2024032689-A1_GT-04194 3-[6-[[4-[2-(4-fluorophenyl)benzoyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccccc5-c5ccc(F)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H29FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-GOLMNI WO2024032689-A1_GT-04196 3-[6-[[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(NN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H30ClN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-V213GT WO2024032689-A1_GT-04204 3-[6-[[1-[[2-(4-chlorophenyl)phenyl]methyl]azetidin-3-yl]amino]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(NC4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)c(F)cc3C2=O)C(=O)N1 Degrader C29H26ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-05WBFT WO2024032689-A1_GT-04222 3-[6-[[4-[3-(4-chlorophenyl)pyridine-4-carbonyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccncc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H28ClN5O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-TREG2C WO2024032689-A1_GT-04252 3-[6-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C32H38ClN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-RTJLTV WO2024032689-A1_GT-04256 3-[6-[[4-[[2-(4-fluorophenyl)phenyl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(F)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-KYL3VU WO2024032689-A1_GT-04275 3-[6-[[4-[[3-(4-chlorophenyl)pyridin-4-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccncc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H30ClN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-V6JUCY WO2024032689-A1_GT-04397 3-[6-[[1-[2-(4-chlorophenyl)benzoyl]azetidin-3-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(NC4CN(C(=O)c5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H25ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-GZXS2M WO2024032689-A1_GT-04719 5-[[3-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2CC3CCC(C2)N3Cc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H39ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-TDQLIK WO2024032689-A1_GT-04947 3-[7-[[4-[2-(4-chlorophenyl)anilino]piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCC(Nc5ccccc5-c5ccc(Cl)cc5)CC4)cccc3C2=O)C(=O)N1 Degrader C31H31ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-N77ZDR WO2024032689-A1_GT-05359 3-[6-[4-[[4-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]piperazin-1-yl]methyl]phenyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CCN(Cc3ccc(-c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)cc3)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C39H41ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-X4QVD1 WO2024032689-A1_GT-05360 3-[4-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H39ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-D4NFER WO2024032689-A1_GT-05361 3-[6-[2-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]ethyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(CCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C34H41ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-52R0OJ WO2024032689-A1_GT-05362 3-[6-[3-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]propyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(CCCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C35H43ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-LMJ0O4 WO2024032689-A1_GT-05363 3-[5-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H39ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-YP95E6 WO2024032689-A1_GT-05366 5-[4-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazine-1-carbonyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2CCN(C(=O)c3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H35ClN4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-RI8K1N WO2024032689-A1_GT-05367 3-[6-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CC(C2)N3Cc2cc3c(cc2F)C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C34H38ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-NW4836 WO2024032689-A1_GT-05369 5-[3-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2CC3CC(C2)N3C(=O)c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H35ClN4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-SZ40WZ WO2024032689-A1_GT-05370 5-[3-[[2-(4-Chlorophenyl)phenyl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(N4C5CCC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)cc3C2=O)C(=O)N1 Degrader C32H29ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-QO4RLA WO2024032689-A1_GT-05371 5-[8-[[2-(4-Chlorophenyl)phenyl]methyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(N4CC5CCC(C4)N5Cc4ccccc4-c4ccc(Cl)cc4)cc3C2=O)C(=O)N1 Degrader C32H29ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-YT3NEP WO2024032689-A1_GT-05372 5-[3-[[2-(4-Chlorophenyl)phenyl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(N4C5CC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)cc3C2=O)C(=O)N1 Degrader C31H27ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-K1S1J7 WO2024032689-A1_GT-05373 5-[6-[[2-(4-Chlorophenyl)phenyl]methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(N4CC5CC(C4)N5Cc4ccccc4-c4ccc(Cl)cc4)cc3C2=O)C(=O)N1 Degrader C31H27ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-AUZC87 WO2024032689-A1_GT-05374 5-[5-[[2-(4-Chlorophenyl)phenyl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(N4CC5CCC4CN5Cc4ccccc4-c4ccc(Cl)cc4)cc3C2=O)C(=O)N1 Degrader C32H29ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-QU348B WO2024032689-A1_GT-05376 5-[8-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2C3CCC2CN(c2ccc4c(c2)C(=O)N(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-XBUTAR WO2024032689-A1_GT-05377 5-[3-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2CC3CC(C2)N3c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C33H35ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-2FO2KR WO2024032689-A1_GT-05378 5-[6-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2C3CC2CN(c2ccc4c(c2)C(=O)N(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C33H35ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-JG6V7O WO2024032689-A1_GT-05379 5-[5-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2CC3CCC2CN3c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-OVROQ1 WO2024032689-A1_GT-05382 3-[6-[[1-[[2-(4-chlorophenyl)phenyl]methyl]azetidin-3-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(NC4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H27ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-4SOP7J WO2024032689-A1_GT-05383 3-[6-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CC(C2)N3Cc2cc(F)c3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H38ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-OHZOZD WO2024032689-A1_GT-05384 5-[3-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2CC3CCC(C2)N3c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-YO979L WO2024032689-A1_GT-05385 2-(2,6-Dioxopiperidin-3-yl)-5-[8-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]isoindole-1,3-dione CC1(C)CCC(CN2C3CCC2CN(c2ccc4c(c2)C(=O)N(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C34H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-7FBPI7 WO2024032689-A1_GT-05386 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]isoindole-1,3-dione CC1(C)CCC(CN2CC3CC(C2)N3c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C33H35FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-DY9OQS WO2024032689-A1_GT-05387 2-(2,6-Dioxopiperidin-3-yl)-5-[6-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]isoindole-1,3-dione CC1(C)CCC(CN2C3CC2CN(c2ccc4c(c2)C(=O)N(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C33H35FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-BKPCDJ WO2024032689-A1_GT-05388 2-(2,6-Dioxopiperidin-3-yl)-5-[5-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]isoindole-1,3-dione CC1(C)CCC(CN2CC3CCC2CN3c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C34H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-UR3X41 WO2024032689-A1_GT-05390 3-[7-fluoro-6-[[4-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3ccc4c(c3F)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C33H38F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-7IIJ9L WO2024032689-A1_GT-05391 3-[5-fluoro-6-[[4-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3cc4c(cc3F)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(F)cc2)C1 Degrader C33H38F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-Y3VZRW WO2024032689-A1_GT-05392 3-[4-fluoro-6-[[4-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3cc(F)c4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C33H38F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-8XH34J WO2024032689-A1_GT-05393 3-[7-[[4-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C33H39FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-RG80U7 WO2024032689-A1_GT-05394 3-[5-[[4-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(F)cc2)C1 Degrader C33H39FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-1XHXYB WO2024032689-A1_GT-05395 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]isoindole-1,3-dione CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C33H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-PINJMG WO2024032689-A1_GT-05396 3-[6-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-1,4-diazepan-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C34H41ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-VK0M6Q WO2024032689-A1_GT-05398 3-[6-[[2-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3C2)=C(c2ccc(F)cc2)C1 Degrader C35H41FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-GWYH8Z WO2024032689-A1_GT-05399 3-[6-[[3-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C34H39FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-70C6O3 WO2024032689-A1_GT-05400 3-[6-[[3-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C35H41FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-AE7234 WO2024032689-A1_GT-05401 . CCC1CN(Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CCN1CC1=C(c2ccc(F)cc2)CC(C)(C)CC1 Degrader C35H43FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-CCBRZ5 WO2024032689-A1_GT-05402 3-[6-[[5-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC3CCC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C35H39FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-SA68LN WO2024032689-A1_GT-05404 3-[6-[[7-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-2,7-diazaspiro[3.5]nonan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C36H41FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-YG8QE8 WO2024032689-A1_GT-05405 3-[6-[[5-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC3CN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3C2)=C(c2ccc(F)cc2)C1 Degrader C35H39FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-KQTHO6 WO2024032689-A1_GT-05411 5-[(1S,4S)-5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2C[C@@H]3C[C@H]2CN3C(=O)c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H35ClN4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-X81EYU WO2024032689-A1_GT-05415 2-(2,6-Dioxopiperidin-3-yl)-5-[4-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]piperazine-1-carbonyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(C(=O)N4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)cc3C2=O)C(=O)N1 Degrader C31H29FN4O6 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-9MDK6V WO2024032689-A1_GT-05416 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(C(=O)N4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)cc3C2=O)C(=O)N1 Degrader C32H29FN4O6 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-40CKQ1 WO2024032689-A1_GT-05418 3-[6-[[4-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-54D3M5 WO2024032689-A1_GT-05419 3-[6-[[1-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]azetidin-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 Degrader C32H34ClN3O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-AS2FMU WO2024032689-A1_GT-05420 . CC1(C)CCC(C(=O)N2CC(=Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 Degrader C32H32ClN3O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-3QR6UZ WO2024032689-A1_GT-05427 3-[6-[[1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3-hydroxyazetidin-3-yl]-hydroxymethyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC(O)(C(O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 Degrader C32H36ClN3O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-NJ235W WO2024032689-A1_GT-05428 3-[6-[[1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]azetidin-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 Degrader C32H36ClN3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-7OQ2DV WO2024032689-A1_GT-05429 3-[6-[8-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C3CCC2CN(c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C34H39ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-C8YX1D WO2024032689-A1_GT-05430 3-[6-[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H39ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-80WD0H WO2024032689-A1_GT-05440 3-[6-[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-TFAH1Z WO2024032689-A1_GT-05441 3-[6-[(1R,4R)-5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C[C@H]3C[C@@H]2CN3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-YZQTTX WO2024032689-A1_GT-05442 3-[6-[(1S,4S)-5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C[C@@H]3C[C@H]2CN3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-NTJCF3 WO2024032689-A1_GT-05445 3-[6-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazine-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCN(C(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-6MSMA9 WO2024032689-A1_GT-05446 3-[6-[8-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octane-3-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C3CCC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C35H39ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-UFF0GP WO2024032689-A1_GT-05447 . O=C1CCC(N2Cc3cc(C(=O)N4CC5CN(CC6=C(c7ccc(F)cc7)CCCC6)CC5C4)ccc3C2=O)C(=O)N1 Degrader C33H35FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-LSW6R7 WO2024032689-A1_GT-05448 3-[6-[4-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]piperazine-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31FN4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-IQVXH2 WO2024032689-A1_GT-05449 3-[6-[3-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)ccc3C2=O)C(=O)N1 Degrader C32H31FN4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-7ZZZO1 WO2024032689-A1_GT-05450 3-[6-[3-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C34H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-PVTJSQ WO2024032689-A1_GT-05451 3-[6-[3-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octane-8-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C35H39FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-UMQSN2 WO2024032689-A1_GT-05452 3-[6-[5-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CC2CN3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C34H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-PB5T1F WO2024032689-A1_GT-05453 3-[6-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-1,4-diazepane-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCCN(C(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C34H39ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-GKWB64 WO2024032689-A1_GT-05454 5-[4-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-1,4-diazepane-1-carbonyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2CCCN(C(=O)c3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-BGMC4Y WO2024032689-A1_GT-05455 3-[6-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazine-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H29ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-XQJ20O WO2024032689-A1_GT-05457 3-[6-[6-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C3CC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-OMW1YP WO2024032689-A1_GT-05458 3-[6-[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octane-8-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H39ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-FSKJCS WO2024032689-A1_GT-05459 3-[5-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3Cc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C35H41ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-FFYCX3 WO2024032689-A1_GT-05460 3-[6-[[5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC2CN3Cc2cc3c(cc2F)C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C35H40ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-VZVL22 WO2024032689-A1_GT-05461 3-[7-[[5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC2CN3Cc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H41ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-8GH5VT WO2024032689-A1_GT-05462 3-[4-[[5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC2CN3Cc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C35H41ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-W5ZTB4 WO2024032689-A1_GT-05463 5-[[5-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1(C)CCC(CN2CC3CCC2CN3Cc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H39ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-T7BP45 WO2024032689-A1_GT-05464 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-[[2-(4-fluorophenyl)cyclohexen-1-yl]methyl]piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCN(CC5=C(c6ccc(F)cc6)CCCC5)CC4)cc3C2=O)C(=O)N1 Degrader C31H33FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-9K72CI WO2024032689-A1_GT-05465 3-[5-[[4-[[2-(4-fluorophenyl)cyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3ccc(CN4CCN(CC5=C(c6ccc(F)cc6)CCCC5)CC4)cc3C2=O)C(=O)N1 Degrader C31H35FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-JLT7FU WO2024032689-A1_GT-05466 3-[7-fluoro-6-[[4-[[2-(4-fluorophenyl)cyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(CC5=C(c6ccc(F)cc6)CCCC5)CC4)c3F)C2=O)C(=O)N1 Degrader C31H34F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-1DILKU WO2024032689-A1_GT-05467 3-[6-[[1-[2-(4-chlorophenyl)benzoyl]piperidin-4-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CC4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C32H30ClN3O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-741R9G WO2024032689-A1_GT-05468 . CC1(C)CCC(C(=O)N2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C33H35FN4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-GF5BJR WO2024032689-A1_GT-05469 3-[4-[[4-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cccc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)c3C2=O)C(=O)N1 Degrader C31H33FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-7TR5DE WO2024032689-A1_GT-05470 3-[5-[[4-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3ccc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)cc3C2=O)C(=O)N1 Degrader C31H33FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-41RYFY WO2024032689-A1_GT-05471 3-[7-[[4-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)cccc3C2=O)C(=O)N1 Degrader C31H33FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-4BVJJ1 WO2024032689-A1_GT-05472 3-[7-fluoro-6-[[4-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)c3F)C2=O)C(=O)N1 Degrader C31H32F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-U8XWYG WO2024032689-A1_GT-05473 3-[5-fluoro-6-[[4-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C31H32F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-D2Z6ZP WO2024032689-A1_GT-05474 3-[4-fluoro-6-[[4-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C31H32F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-YLUB1L WO2024032689-A1_GT-05475 3-[7-fluoro-6-[[3-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)c3F)C2=O)C(=O)N1 Degrader C32H32F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-R310EK WO2024032689-A1_GT-05476 3-[5-fluoro-6-[[3-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)c(F)cc3C2=O)C(=O)N1 Degrader C32H32F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-V2XJ5J WO2024032689-A1_GT-05477 3-[4-fluoro-6-[[3-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)cc(F)c3C2=O)C(=O)N1 Degrader C32H32F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-I0ON3B WO2024032689-A1_GT-05478 3-[7-[[3-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)cccc3C2=O)C(=O)N1 Degrader C32H33FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-U6CN1K WO2024032689-A1_GT-05479 3-[5-[[3-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3ccc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)cc3C2=O)C(=O)N1 Degrader C32H33FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-WBXR20 WO2024032689-A1_GT-05480 3-[4-[[3-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cccc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)c3C2=O)C(=O)N1 Degrader C32H33FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-IWVAIX WO2024032689-A1_GT-05481 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[2-(4-fluorophenyl)cyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)cc3C2=O)C(=O)N1 Degrader C32H31FN4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-I20PL8 WO2024032689-A1_GT-05482 . O=C1CCC(N2Cc3cc(C=C4CN(C(=O)c5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H24ClN3O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-GJ2WDQ WO2024032689-A1_GT-05483 . CC1(C)CCC(CN2CC(=Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 Degrader C32H34FN3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-ZYSSLB WO2024032689-A1_GT-05484 3-[6-[[1-[2-(4-chlorophenyl)benzoyl]-3-hydroxyazetidin-3-yl]-hydroxymethyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(O)C4(O)CN(C(=O)c5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H26ClN3O6 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-6SLGOO WO2024032689-A1_GT-05485 3-[5-[[5-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC2CN3Cc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C35H41ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-KV97GO WO2024032689-A1_GT-05486 3-[7-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazine-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(C(=O)N4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)cccc3C2=O)C(=O)N1 Degrader C31H29ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-GL23SH WO2024032689-A1_GT-05487 3-[6-[[1-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]piperidin-4-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CCC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C34H38FN3O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-SH2SY9 WO2024032689-A1_GT-05488 3-[6-[[1-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]azetidin-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 Degrader C32H34FN3O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-891KJV WO2024032689-A1_GT-05489 . CC1(C)CCC(C(=O)N2CC(=Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 Degrader C32H32FN3O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-YK84S3 WO2024032689-A1_GT-05490 3-[6-[[1-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-3-hydroxyazetidin-3-yl]-hydroxymethyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC(O)(C(O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 Degrader C32H34FN3O6 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-ZEMG32 WO2024032689-A1_GT-05491 3-[6-[8-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2C3CCC2CN(c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C34H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-XH131C WO2024032689-A1_GT-05492 3-[6-[3-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC3CCC(C2)N3c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C34H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-8QFGU0 WO2024032689-A1_GT-05493 3-[6-[[1-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]azetidin-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 Degrader C32H36FN3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-E6R90A WO2024032689-A1_GT-05494 3-[6-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3Cc2cc3c(cc2F)C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C35H40ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-HCSU6A WO2024032689-A1_GT-05495 3-[6-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3Cc2cc(F)c3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H40ClFN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-9RRUVZ WO2024032689-A1_GT-05497 5-[[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H29ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-XZ51XN WO2024032689-A1_GT-05498 3-[6-[3-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC(C2)N3c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C34H39FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-A5WLNL WO2024032689-A1_GT-05499 3-[6-[[1-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3-hydroxyazetidin-3-yl]-hydroxymethyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC(O)(C(O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 Degrader C32H36FN3O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-H542DW WO2024032689-A1_GT-05500 3-[6-[8-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C3CCC2CN(c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C34H39FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-6RQBVB WO2024032689-A1_GT-05504 3-[6-[[4-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-1,4-diazepan-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C34H41FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-EH7F6C WO2024032689-A1_GT-05505 3-[6-[4-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-1,4-diazepane-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCCN(C(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C34H39FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-BKVA3K WO2024032689-A1_GT-05506 3-[6-[[7-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCC3(CC2)CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C36H43FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-T0QN6I WO2024032689-A1_GT-05507 3-[6-[7-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,7-diazaspiro[3.5]nonane-2-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCC3(CC2)CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C36H41FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-EDY50G WO2024032689-A1_GT-05508 3-[6-[6-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,6-diazaspiro[3.3]heptane-2-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3(C2)CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C34H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-273A46 WO2024032689-A1_GT-05509 3-[6-[[6-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C3CC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C34H39FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-SRJTK1 WO2024032689-A1_GT-05510 3-[6-[[8-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C3CCC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C35H41FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-USG009 WO2024032689-A1_GT-05511 3-[6-[8-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,8-diazabicyclo[3.2.1]octane-3-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2C3CCC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C35H39FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-PER429 WO2024032689-A1_GT-05512 3-[6-[[5-[[2-(4-fluorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC3CCC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C35H41FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-YROFGV WO2024032689-A1_GT-05514 3-[6-[[3-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC3CC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C34H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-3Q0X4X WO2024032689-A1_GT-05515 . CCC1CN(Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CCN1C(=O)C1=C(c2ccc(F)cc2)CC(C)(C)CC1 Degrader C35H41FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-A52OTS WO2024032689-A1_GT-05516 3-[6-[[3-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC3CCC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 Degrader C35H39FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-PRXB84 WO2024032689-A1_GT-05517 3-[6-[[8-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2C3CCC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 Degrader C35H39FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-944K1W WO2024032689-A1_GT-05519 3-[3-oxo-6-[[4-[(2-thiophen-2-ylphenyl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5cccs5)CC4)ccc3C2=O)C(=O)N1 Degrader C29H30N4O3S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-89WWV5 WO2024032689-A1_GT-05520 3-[6-[[4-[2-(4-fluorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 Degrader C33H37FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-QQLAH1 WO2024032689-A1_GT-05521 3-[6-[[3-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC3CC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-O35TUN WO2024032689-A1_GT-05522 3-[6-[[3-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC3CCC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C35H39ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-8SJWMP WO2024032689-A1_GT-05523 3-[6-[[8-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2C3CCC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 Degrader C35H39ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-EC867A WO2024032689-A1_GT-05524 3-[6-[[5-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CC3CC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 Degrader C34H37ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024032689-A1 TPD-87JP1U WO2024039689-A1_1 . Cc1ccc(NS(=O)(=O)c2nc(-c3ccccc3)cs2)c2[nH]cc(C#N)c12 Degrader C19H14N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-ZK2RSY US20240092770, Compound 10 4-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-5-methyl-1,3-thiazole-2-sulfonamide\; BDBM659432; US20240092770, Compound 10 Cc1sc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)nc1C#N Degrader C15H11N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-FDYHE9 US20240092770, Compound 100 2-tert-butyl-N-(3-cyano-4-methyl-1H-indol-7-yl)-1,3-oxazole-5-sulfonamide\; BDBM659494; US20240092770, Compound 100 Cc1ccc(NS(=O)(=O)c2cnc(C(C)(C)C)o2)c2[nH]cc(C#N)c12 Degrader C17H18N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-JD9LZ8 WO2024039689-A1_101 . Cc1cnc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)s1 Degrader C13H10N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-QQYD23 N-(1H-indazol-7-yl)-1,3-thiazole-2-sulfonamide BDBM659495; US20240092770, Compound 102 O=S(=O)(Nc1cccc2cn[nH]c12)c1nccs1 Degrader C10H8N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-N2VHE2 N-(3-cyano-1H-indol-7-yl)-5-methyl-1,3-thiazole-4-sulfonamide BDBM659496; US20240092770, Compound 103 Cc1scnc1S(=O)(=O)Nc1cccc2c(C#N)c[nH]c12 Degrader C13H10N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-EI3T6T 3-tert-butyl-N-(3-cyano-1H-indol-7-yl)-1,2-oxazole-5-sulfonamide BDBM659497; US20240092770, Compound 104 CC(C)(C)c1cc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)on1 Degrader C16H16N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-5K9S3Y US20240092770, Compound 105 N-(3-cyano-1H-indol-7-yl)-2-(difluoromethyl)-1,3-thiazole-4-sulfonamide\; BDBM659498; US20240092770, Compound 105 N#Cc1c[nH]c2c(NS(=O)(=O)c3csc(C(F)F)n3)cccc12 Degrader C13H8F2N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-AOJMHO WO2024039689-A1_106 . CC(C)(C)c1nnc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)[nH]1 Degrader C15H16N6O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-GCJOD2 N-(3-cyano-1H-indol-7-yl)-2-cyclopropyl-1,3-oxazole-5-sulfonamide SCHEMBL27174902; BDBM659499; US20240092770, Compound 107 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(C4CC4)o3)cccc12 Degrader C15H12N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-S40VS2 N-(3-cyano-1H-indol-7-yl)-2-methyl-1,3-oxazole-5-sulfonamide BDBM659500; US20240092770, Compound 108 Cc1ncc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)o1 Degrader C13H10N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-1SMV92 2-bromo-N-(3-cyano-1H-indol-7-yl)-4-methyl-1,3-thiazole-5-sulfonamide BDBM659501; US20240092770, Compound 109 Cc1nc(Br)sc1S(=O)(=O)Nc1cccc2c(C#N)c[nH]c12 Degrader C13H9BrN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-3R45K0 US20240092770, Compound 11 4-bromo-N-(3-cyano-4-methyl-1H-indol-7-yl)-5-methyl-1,3-thiazole-2-sulfonamide\; BDBM659433; US20240092770, Compound 11 Cc1sc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)nc1Br Degrader C14H11BrN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-P3IFJK 2-tert-butyl-N-(3-cyano-1H-indol-7-yl)-1,3-oxazole-5-sulfonamide BDBM659502; US20240092770, Compound 110 CC(C)(C)c1ncc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)o1 Degrader C16H16N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-ROIAJP US20240092770, Compound 111 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-dimethylphosphoryl-1,3-thiazole-2-sulfonamide\; SCHEMBL27174977; BDBM659503; US20240092770, Compound 111 Cc1ccc(NS(=O)(=O)c2ncc(P(C)(C)=O)s2)c2[nH]cc(C#N)c12 Degrader C15H15N4O3PS2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-L9UPDP US20240092770, Compound 112 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-(morpholine-4-carbonyl)-1,3-thiazole-2-sulfonamide\; BDBM659504; US20240092770, Compound 112 Cc1ccc(NS(=O)(=O)c2ncc(C(=O)N3CCOCC3)s2)c2[nH]cc(C#N)c12 Degrader C18H17N5O4S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-FP1WLP WO2024039689-A1_113 . O=S(=O)(Nc1ccc(F)c2c(Cl)c[nH]c12)c1nccs1 Degrader C11H7ClFN3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-0J44GE N-(3-cyano-4-fluoro-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide BDBM659505; US20240092770, Compound 113; US20240092770, Compound 114 N#Cc1c[nH]c2c(NS(=O)(=O)c3nccs3)ccc(F)c12 Degrader C12H7FN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-81DLZZ WO2024039689-A1_115 . O=S(=O)(Nc1cc(F)cc2c(Cl)c[nH]c12)c1nccs1 Degrader C11H7ClFN3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-S4CJQL 5-chloro-N-(3-cyano-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide BDBM659507; US20240092770, Compound 116 N#Cc1c[nH]c2c(NS(=O)(=O)c3ncc(Cl)s3)cccc12 Degrader C12H7ClN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-NE8N5A US20240092770, Compound 117 N-(3-cyano-4-methyl-1H-indol-7-yl)-2-(difluoromethyl)-1,3-thiazole-5-sulfonamide\; BDBM659508; US20240092770, Compound 117 Cc1ccc(NS(=O)(=O)c2cnc(C(F)F)s2)c2[nH]cc(C#N)c12 Degrader C14H10F2N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-45JO6P N-(3-cyano-4-methyl-1H-indol-7-yl)-2-ethyl-1,3-oxazole-5-sulfonamide BDBM659509; US20240092770, Compound 118 CCc1ncc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)o1 Degrader C15H14N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-WE4Y3O N-(3-cyano-4-methyl-1H-indol-7-yl)-3-ethyl-1,2-oxazole-4-sulfonamide 0 CCc1nocc1S(=O)(=O)Nc1ccc(C)c2c(C#N)c[nH]c12 Degrader C15H14N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-Y0MI5R US20240092770, Compound 12 N-(3-cyano-4-methyl-1H-indol-7-yl)-4-(trifluoromethyl)-1,3-thiazole-2-sulfonamide\; SCHEMBL27174931; BDBM659434; US20240092770, Compound 12 Cc1ccc(NS(=O)(=O)c2nc(C(F)(F)F)cs2)c2[nH]cc(C#N)c12 Degrader C14H9F3N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-G01BXV US20240092770, Compound 120 N-(3-cyano-1H-indol-7-yl)-2-(difluoromethyl)-1,3-thiazole-5-sulfonamide\; BDBM659510; US20240092770, Compound 120 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(C(F)F)s3)cccc12 Degrader C13H8F2N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-PH7NRA N-(3-cyano-1H-indol-7-yl)-2-ethyl-1,3-oxazole-5-sulfonamide BDBM659511; US20240092770, Compound 121 CCc1ncc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)o1 Degrader C14H12N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-YI1MT2 N-(3-cyano-1H-indol-7-yl)-3-ethyl-1,2-oxazole-4-sulfonamide 0 CCc1nocc1S(=O)(=O)Nc1cccc2c(C#N)c[nH]c12 Degrader C14H12N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-V8HAR4 2-ethyl-N-(1H-indazol-7-yl)-1H-imidazole-5-sulfonamide AKOS013470157 CCc1nc(S(=O)(=O)Nc2cccc3cn[nH]c23)c[nH]1 Degrader C12H13N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-RRVCHL N-(1H-indazol-7-yl)-4-(trifluoromethyl)-1,3-thiazole-2-sulfonamide 0 O=S(=O)(Nc1cccc2cn[nH]c12)c1nc(C(F)(F)F)cs1 Degrader C11H7F3N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-Z637RQ N-(3-chloro-2H-indazol-7-yl)-2-ethyl-1H-imidazole-5-sulfonamide 0 CCc1nc(S(=O)(=O)Nc2cccc3c(Cl)n[nH]c23)c[nH]1 Degrader C12H12ClN5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-414FJ2 US20240092770, Compound 126 2-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-N-methyl-1,3-thiazole-5-carboxamide\; BDBM659513; US20240092770, Compound 126 CNC(=O)c1cnc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)s1 Degrader C15H13N5O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-2VD2OU US20240092770, Compound 127 2-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-N,N-dimethyl-1,3-thiazole-5-carboxamide\; BDBM659514; US20240092770, Compound 127 Cc1ccc(NS(=O)(=O)c2ncc(C(=O)N(C)C)s2)c2[nH]cc(C#N)c12 Degrader C16H15N5O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-WC3RYT WO2024039689-A1_128 2-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-N,N-diethyl-1,3-thiazole-5-carboxamide CCN(CC)C(=O)c1cnc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)s1 Degrader C18H19N5O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-WT9X90 US20240092770, Compound 129 2-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-N-(2-hydroxyethyl)-1,3-thiazole-5-carboxamide\; BDBM659516; US20240092770, Compound 129 Cc1ccc(NS(=O)(=O)c2ncc(C(=O)NCCO)s2)c2[nH]cc(C#N)c12 Degrader C16H15N5O4S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-8EUUT9 4-bromo-N-(3-cyano-4-methyl-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide BDBM659435; US20240092770, Compound 13 Cc1ccc(NS(=O)(=O)c2nc(Br)cs2)c2[nH]cc(C#N)c12 Degrader C13H9BrN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-BN7BNQ US20240092770, Compound 130 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-(pyrrolidine-1-carbonyl)-1,3-thiazole-2-sulfonamide\; BDBM659517; US20240092770, Compound 130 Cc1ccc(NS(=O)(=O)c2ncc(C(=O)N3CCCC3)s2)c2[nH]cc(C#N)c12 Degrader C18H17N5O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-C86CVL US20240092770, Compound 131 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-(4-methylpiperazine-1-carbonyl)-1,3-thiazole-2-sulfonamide\; BDBM659518; US20240092770, Compound 131 Cc1ccc(NS(=O)(=O)c2ncc(C(=O)N3CCN(C)CC3)s2)c2[nH]cc(C#N)c12 Degrader C19H20N6O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-EX1CPB N-(3-cyano-5-fluoro-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide BDBM659519; US20240092770, Compound 132 N#Cc1c[nH]c2c(NS(=O)(=O)c3nccs3)cc(F)cc12 Degrader C12H7FN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-1P1PVH N-(3-chloro-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide BDBM659520; US20240092770, Compound 133 O=S(=O)(Nc1cccc2c(Cl)c[nH]c12)c1nccs1 Degrader C11H8ClN3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-YIKVMB US20240092770, Compound 134 N-(3-cyano-1H-indol-7-yl)-4-(trifluoromethyl)-1,3-thiazole-2-sulfonamide\; BDBM659521; US20240092770, Compound 134 N#Cc1c[nH]c2c(NS(=O)(=O)c3nc(C(F)(F)F)cs3)cccc12 Degrader C13H7F3N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-2B0KBD US20240092770, Compound 135 N-(3-cyano-4-methyl-1H-indol-7-yl)-3-propan-2-yl-1,2-oxazole-5-sulfonamide\; BDBM659522; US20240092770, Compound 135 Cc1ccc(NS(=O)(=O)c2cc(C(C)C)no2)c2[nH]cc(C#N)c12 Degrader C16H16N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-AP9JRY 2-chloro-N-(3-cyano-1H-indol-7-yl)-1,3-thiazole-5-sulfonamide BDBM659523; US20240092770, Compound 136 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(Cl)s3)cccc12 Degrader C12H7ClN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-12SE7O N-(3-chloro-2H-indazol-7-yl)-1,3-thiazole-2-sulfonamide 0 O=S(=O)(Nc1cccc2c(Cl)n[nH]c12)c1nccs1 Degrader C10H7ClN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-YZNYG4 N-(3-cyano-1H-indol-7-yl)-3-propan-2-yl-1,2-oxazole-5-sulfonamide BDBM659524; US20240092770, Compound 138 CC(C)c1cc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)on1 Degrader C15H14N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-9I3NXM US20240092770, Compound 139 2-[4-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-2-ethylimidazol-1-yl]-N-cyclopropylacetamide\; SCHEMBL27174964; BDBM659525; US20240092770, Compound 139 CCc1nc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cn1CC(=O)NC1CC1 Degrader C20H22N6O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-FPITZ5 WO2024039689-A1_14 . Cc1sc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)nc1-c1cnn(C)c1 Degrader C18H16N6O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-80OJ87 US20240092770, Compound 140 2-[4-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-2-ethylimidazol-1-yl]acetic acid\; SCHEMBL27174887; BDBM659526; US20240092770, Compound 140 CCc1nc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cn1CC(=O)O Degrader C17H17N5O4S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-XUWIWW US20240092770, Compound 141 2-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-1,3-thiazole-5-carboxamide\; BDBM659527; US20240092770, Compound 141 Cc1ccc(NS(=O)(=O)c2ncc(C(N)=O)s2)c2[nH]cc(C#N)c12 Degrader C14H11N5O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-CBR6W9 US20240092770, Compound 142 2-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-N-(2-methoxyethyl)-1,3-thiazole-5-carboxamide\; BDBM659528; US20240092770, Compound 142 COCCNC(=O)c1cnc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)s1 Degrader C17H17N5O4S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-MGCOMT US20240092770, Compound 143 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-(3-hydroxypyrrolidine-1-carbonyl)-1,3-thiazole-2-sulfonamide\; BDBM659529; US20240092770, Compound 143 Cc1ccc(NS(=O)(=O)c2ncc(C(=O)N3CCC(O)C3)s2)c2[nH]cc(C#N)c12 Degrader C18H17N5O4S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-KV8XR7 US20240092770, Compound 144 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-(piperidine-1-carbonyl)-1,3-thiazole-2-sulfonamide\; BDBM659530; US20240092770, Compound 144 Cc1ccc(NS(=O)(=O)c2ncc(C(=O)N3CCCCC3)s2)c2[nH]cc(C#N)c12 Degrader C19H19N5O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-4CN738 WO2024039689-A1_145 . Cc1ccc(NS(=O)(=O)c2ncc(C(=O)N3CCNCC3)s2)c2[nH]cc(C#N)c12 Degrader C18H18N6O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-A15HXP N-(3-chloro-4-fluoro-1H-indol-7-yl)-2-ethyl-1H-imidazole-5-sulfonamide BDBM659531; US20240092770, Compound 146 CCc1nc(S(=O)(=O)Nc2ccc(F)c3c(Cl)c[nH]c23)c[nH]1 Degrader C13H12ClFN4O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-V8UZYO N-(3-cyano-4-fluoro-1H-indol-7-yl)-2-ethyl-1H-imidazole-5-sulfonamide BDBM659532; US20240092770, Compound 147 CCc1nc(S(=O)(=O)Nc2ccc(F)c3c(C#N)c[nH]c23)c[nH]1 Degrader C14H12FN5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-G6FIY3 US20240092770, Compound 148 N-(3-cyano-4-fluoro-1H-indol-7-yl)-4-(trifluoromethyl)-1,3-thiazole-2-sulfonamide\; BDBM659533; US20240092770, Compound 148 N#Cc1c[nH]c2c(NS(=O)(=O)c3nc(C(F)(F)F)cs3)ccc(F)c12 Degrader C13H6F4N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-CMEI9W US20240092770, Compound 149 N-(3-chloro-5-fluoro-1H-indol-7-yl)-4-(trifluoromethyl)-1,3-thiazole-2-sulfonamide\; BDBM659534; US20240092770, Compound 149 O=S(=O)(Nc1cc(F)cc2c(Cl)c[nH]c12)c1nc(C(F)(F)F)cs1 Degrader C12H6ClF4N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-LVHOZQ WO2024039689-A1_15 . Cc1sc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)nc1-c1ccncc1 Degrader C19H15N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-T6WB9V US20240092770, Compound 150 N-(3-cyano-5-fluoro-1H-indol-7-yl)-4-(trifluoromethyl)-1,3-thiazole-2-sulfonamide\; BDBM659535; US20240092770, Compound 150 N#Cc1c[nH]c2c(NS(=O)(=O)c3nc(C(F)(F)F)cs3)cc(F)cc12 Degrader C13H6F4N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-NB3PII US20240092770, Compound 151 N-(3-chloro-1H-indol-7-yl)-4-(trifluoromethyl)-1,3-thiazole-2-sulfonamide\; BDBM659536; US20240092770, Compound 151 O=S(=O)(Nc1cccc2c(Cl)c[nH]c12)c1nc(C(F)(F)F)cs1 Degrader C12H7ClF3N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-OIDVL6 N-(3-cyano-4-methyl-1H-indol-7-yl)-2-methyl-1,3-thiazole-4-sulfonamide BDBM659537; US20240092770, Compound 152 Cc1nc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cs1 Degrader C14H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-86Y8GS N-(3-cyano-1H-indol-7-yl)-2-methyl-1,3-thiazole-4-sulfonamide BDBM659538; US20240092770, Compound 153 Cc1nc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)cs1 Degrader C13H10N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-2XW9KG WO2024039689-A1_154 N-(3-chloro-2H-indazol-7-yl)-4-(trifluoromethyl)-1,3-thiazole-2-sulfonamide O=S(=O)(Nc1cccc2c(Cl)n[nH]c12)c1nc(C(F)(F)F)cs1 Degrader C11H6ClF3N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-BGOKPS WO2024039689-A1_155 . Cc1ccc(NS(=O)(=O)c2ncc(-c3c[nH]cn3)s2)c2[nH]cc(C#N)c12 Degrader C16H12N6O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-57PY1H WO2024039689-A1_156 . CCc1nc(S(=O)(=O)Nc2cc(F)cc3c(Cl)c[nH]c23)c[nH]1 Degrader C13H12ClFN4O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-NX3HFL N-(3-cyano-5-fluoro-1H-indol-7-yl)-2-ethyl-1H-imidazole-5-sulfonamide BDBM659539; US20240092770, Compound 157 CCc1nc(S(=O)(=O)Nc2cc(F)cc3c(C#N)c[nH]c23)c[nH]1 Degrader C14H12FN5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-FQH82Z N-(3-chloro-1H-indol-7-yl)-2-ethyl-1H-imidazole-5-sulfonamide BDBM659540; US20240092770, Compound 158 CCc1nc(S(=O)(=O)Nc2cccc3c(Cl)c[nH]c23)c[nH]1 Degrader C13H13ClN4O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-01K71M US20240092770, Compound 159 N-(3-chloro-4-fluoro-1H-indol-7-yl)-4-(trifluoromethyl)-1,3-thiazole-2-sulfonamide\; SCHEMBL27174976; BDBM659541; US20240092770, Compound 159 O=S(=O)(Nc1ccc(F)c2c(Cl)c[nH]c12)c1nc(C(F)(F)F)cs1 Degrader C12H6ClF4N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-AHOO51 WO2024039689-A1_16 . Cc1sc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)nc1-c1cccnc1 Degrader C19H15N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-F1Y7U4 N-(3-cyano-1H-indol-7-yl)-4,5-dimethyl-1,3-thiazole-2-sulfonamide BDBM659542; US20240092770, Compound 160 Cc1nc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)sc1C Degrader C14H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-200WMT US20240092770, Compound 161 N-(3-cyano-4-methyl-1H-indol-7-yl)-1-(2-methylpropyl)imidazole-4-sulfonamide\; BDBM659543; US20240092770, Compound 161 Cc1ccc(NS(=O)(=O)c2cn(CC(C)C)cn2)c2[nH]cc(C#N)c12 Degrader C17H19N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-PC0REY N-(3-cyano-4-methyl-1H-indol-7-yl)-1-propylimidazole-4-sulfonamide BDBM659544; US20240092770, Compound 162 CCCn1cnc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)c1 Degrader C16H17N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-XX7B3Y 4-chloro-N-(3-cyano-4-fluoro-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide BDBM659545; US20240092770, Compound 163 N#Cc1c[nH]c2c(NS(=O)(=O)c3nc(Cl)cs3)ccc(F)c12 Degrader C12H6ClFN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-DH0S3X WO2024039689-A1_164 N-[4-methyl-3-(trifluoromethyl)-1H-indol-7-yl]-1,3-thiazole-2-sulfonamide Cc1ccc(NS(=O)(=O)c2nccs2)c2[nH]cc(C(F)(F)F)c12 Degrader C13H10F3N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-KRVPI7 WO2024039689-A1_165 . CCc1nc(S(=O)(=O)Nc2cccc3c(C#N)n[nH]c23)c[nH]1 Degrader C13H12N6O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-BQTHTA N-(3-cyano-4-methyl-1H-indol-7-yl)-5-methyl-1H-imidazole-4-sulfonamide 0 Cc1[nH]cnc1S(=O)(=O)Nc1ccc(C)c2c(C#N)c[nH]c12 Degrader C14H13N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-79TPN0 WO2024039689-A1_167 . CCn1cnc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)c1 Degrader C15H15N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-6AG25F WO2024039689-A1_168 N-(3-cyano-4-methyl-1H-indol-7-yl)-1-propan-2-ylimidazole-4-sulfonamide Cc1ccc(NS(=O)(=O)c2cn(C(C)C)cn2)c2[nH]cc(C#N)c12 Degrader C16H17N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-NLEI1I WO2024039689-A1_169 . Cc1ccc(NS(=O)(=O)c2cn(C)c(C(C)C)n2)c2[nH]cc(C#N)c12 Degrader C17H19N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-OO7OFO WO2024039689-A1_17 . Cc1sc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)nc1-c1cn[nH]c1 Degrader C17H14N6O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-6TIKDA WO2024039689-A1_170 . Cc1ccc(NS(=O)(=O)c2cn(C)c(Cl)n2)c2[nH]cc(C#N)c12 Degrader C14H12ClN5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-5P8530 WO2024039689-A1_171 . Cc1ccc(NS(=O)(=O)c2cn(C)c(C)n2)c2[nH]cc(C#N)c12 Degrader C15H15N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-RCU7SW 5-chloro-N-(3-cyano-4-fluoro-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3ncc(Cl)s3)ccc(F)c12 Degrader C12H6ClFN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-6LSN2N WO2024039689-A1_173 . N#Cc1n[nH]c2c(NS(=O)(=O)c3nccs3)cccc12 Degrader C11H7N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-7BRF82 N-(3-cyano-4-methyl-1H-indol-7-yl)-3-methylimidazole-4-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2cncn2C)c2[nH]cc(C#N)c12 Degrader C14H13N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-01VXN4 WO2024039689-A1_175 . CCn1cncc1S(=O)(=O)Nc1ccc(C)c2c(C#N)c[nH]c12 Degrader C15H15N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-LYQDXQ WO2024039689-A1_176 . CCn1c(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cnc1C Degrader C16H17N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-38VUO3 WO2024039689-A1_177 5-bromo-N-(3-cyano-4-methyl-1H-indol-7-yl)-1,2-dimethylimidazole-4-sulfonamide Cc1ccc(NS(=O)(=O)c2nc(C)n(C)c2Br)c2[nH]cc(C#N)c12 Degrader C15H14BrN5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-S1S50E WO2024039689-A1_178 . Cc1ccc(NS(=O)(=O)c2cnc(Cl)n2C)c2[nH]cc(C#N)c12 Degrader C14H12ClN5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-GCXXQ7 WO2024039689-A1_179 . Cc1ccc(NS(=O)(=O)c2nccn2C)c2[nH]cc(C#N)c12 Degrader C14H13N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-A55X60 WO2024039689-A1_18 . Cc1ccc(NS(=O)(=O)c2nc(-c3cnn(C)c3)cs2)c2[nH]cc(C#N)c12 Degrader C17H14N6O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-P9K65K WO2024039689-A1_180 . Cc1ccc(NS(=O)(=O)c2ncn(C)c2Cl)c2[nH]cc(C#N)c12 Degrader C14H12ClN5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-0YXS23 2-chloro-N-(3-chloro-2H-indazol-7-yl)-1,3-thiazole-5-sulfonamide 0 O=S(=O)(Nc1cccc2c(Cl)n[nH]c12)c1cnc(Cl)s1 Degrader C10H6Cl2N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-EG6NOB 5-chloro-N-(3-chloro-2H-indazol-7-yl)-1,3-thiazole-2-sulfonamide 0 O=S(=O)(Nc1cccc2c(Cl)n[nH]c12)c1ncc(Cl)s1 Degrader C10H6Cl2N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-TH429J WO2024039689-A1_183 . N#Cc1n[nH]c2c(NS(=O)(=O)c3ncc(Cl)s3)cccc12 Degrader C11H6ClN5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-DI4TBG 2-chloro-N-(3-cyano-4-fluoro-1H-indol-7-yl)-1,3-thiazole-5-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(Cl)s3)ccc(F)c12 Degrader C12H6ClFN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-80ZA4L N-[3-(trifluoromethyl)-1H-indol-7-yl]-1,3-thiazole-2-sulfonamide BDBM659546; US20240092770, Compound 185 O=S(=O)(Nc1cccc2c(C(F)(F)F)c[nH]c12)c1nccs1 Degrader C12H8F3N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-DO83NK N-[3-(trifluoromethyl)-1H-indol-7-yl]-1,3-thiazole-5-sulfonamide BDBM659547; US20240092770, Compound 186 O=S(=O)(Nc1cccc2c(C(F)(F)F)c[nH]c12)c1cncs1 Degrader C12H8F3N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-Q257AB N-(3-chloro-4-fluoro-1H-indol-7-yl)-1,3-thiazole-5-sulfonamide BDBM659548; US20240092770, Compound 187 O=S(=O)(Nc1ccc(F)c2c(Cl)c[nH]c12)c1cncs1 Degrader C11H7ClFN3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-238J0M WO2024039689-A1_188 N-(3-chloro-4-fluoro-1H-indol-7-yl)-2-methyl-1,3-thiazole-5-sulfonamide Cc1ncc(S(=O)(=O)Nc2ccc(F)c3c(Cl)c[nH]c23)s1 Degrader C12H9ClFN3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-PR5B9K WO2024039689-A1_189 N-(3-cyano-4-methyl-1H-indol-7-yl)-4,5-dimethyl-1,3-thiazole-2-sulfonamide Cc1nc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)sc1C Degrader C15H14N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-G0RAY9 WO2024039689-A1_19 . Cc1csc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)n1 Degrader C14H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-FA9UTO WO2024039689-A1_190 . Cc1ccc(NS(=O)(=O)c2cn(C)cn2)c2[nH]cc(C#N)c12 Degrader C14H13N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-7BO333 WO2024039689-A1_191 . CCn1cc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)nc1C Degrader C16H17N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-EMPDLP WO2024039689-A1_192 . Cc1ccc(NS(=O)(=O)c2cnc(C)n2C)c2[nH]cc(C#N)c12 Degrader C15H15N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-7NMPZ6 WO2024039689-A1_193 5-tert-butyl-N-(3-cyano-4-methyl-1H-indol-7-yl)-1H-imidazole-4-sulfonamide Cc1ccc(NS(=O)(=O)c2nc[nH]c2C(C)(C)C)c2[nH]cc(C#N)c12 Degrader C17H19N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-Y7DS5S WO2024039689-A1_194 5-chloro-N-(3-cyano-4-methyl-1H-indol-7-yl)-1,2-dimethylimidazole-4-sulfonamide Cc1ccc(NS(=O)(=O)c2nc(C)n(C)c2Cl)c2[nH]cc(C#N)c12 Degrader C15H14ClN5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-9UGPFD WO2024039689-A1_195 . CCc1ncc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)n1CC1CC1 Degrader C19H21N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-8LQBBE 4-chloro-N-(3-cyano-4-methyl-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2nc(Cl)cs2)c2[nH]cc(C#N)c12 Degrader C13H9ClN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-TF4U6Z 4-chloro-N-(3-cyano-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3nc(Cl)cs3)cccc12 Degrader C12H7ClN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-7NK6VP US20240092770, Compound 198 N-[4-methyl-3-(trifluoromethyl)-1H-indol-7-yl]-1,3-thiazole-5-sulfonamide\; BDBM659549; US20240092770, Compound 198 Cc1ccc(NS(=O)(=O)c2cncs2)c2[nH]cc(C(F)(F)F)c12 Degrader C13H10F3N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-1BQXIM N-(3-cyano-4-fluoro-1H-indol-7-yl)-1,3-thiazole-5-sulfonamide BDBM659550; US20240092770, Compound 199 N#Cc1c[nH]c2c(NS(=O)(=O)c3cncs3)ccc(F)c12 Degrader C12H7FN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-9PT9SG N-(3-cyano-4-methyl-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide BDBM659427; US20240092770, Compound 2 Cc1ccc(NS(=O)(=O)c2nccs2)c2[nH]cc(C#N)c12 Degrader C13H10N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-7ZPHLY WO2024039689-A1_20 . Cc1ccc(NS(=O)(=O)c2nc(-c3cccnc3)cs2)c2[nH]cc(C#N)c12 Degrader C18H13N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-6ANRJN N-(3-chloro-1H-indol-7-yl)-2-methyl-1,3-thiazole-5-sulfonamide BDBM659551; US20240092770, Compound 200 Cc1ncc(S(=O)(=O)Nc2cccc3c(Cl)c[nH]c23)s1 Degrader C12H10ClN3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-0I6ZXG N-(3-cyano-4-fluoro-1H-indol-7-yl)-2-methyl-1,3-thiazole-5-sulfonamide BDBM659552; US20240092770, Compound 201 Cc1ncc(S(=O)(=O)Nc2ccc(F)c3c(C#N)c[nH]c23)s1 Degrader C13H9FN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-NVTWJ4 US20240092770, Compound 202 N-(3-cyano-1H-indol-7-yl)-2-(2-hydroxypropan-2-yl)-1,3-thiazole-5-sulfonamide\; BDBM659553; US20240092770, Compound 202 CC(C)(O)c1ncc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)s1 Degrader C15H14N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-Z67UAS N-(3-chloro-1H-indol-7-yl)-1,3-thiazole-5-sulfonamide BDBM659554; US20240092770, Compound 203 O=S(=O)(Nc1cccc2c(Cl)c[nH]c12)c1cncs1 Degrader C11H8ClN3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-QSY174 US20240092770, Compound 204 N-(3-chloro-1H-indol-7-yl)-2-(difluoromethyl)-1,3-thiazole-5-sulfonamide\; BDBM659555; US20240092770, Compound 204 O=S(=O)(Nc1cccc2c(Cl)c[nH]c12)c1cnc(C(F)F)s1 Degrader C12H8ClF2N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-XGKVTD N-(3-cyano-1H-indol-7-yl)-2-morpholin-4-yl-1,3-thiazole-5-sulfonamide BDBM659556; US20240092770, Compound 205 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(N4CCOCC4)s3)cccc12 Degrader C16H15N5O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-6RI6M2 WO2024039689-A1_206 N-(3-cyano-1H-indol-7-yl)-2-(2H-triazol-4-yl)-1,3-thiazole-5-sulfonamide N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(-c4cnn[nH]4)s3)cccc12 Degrader C14H9N7O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-0ZPIJ7 3-bromo-N-(3-cyano-4-methyl-1H-indol-7-yl)-1,2-oxazole-5-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2cc(Br)no2)c2[nH]cc(C#N)c12 Degrader C13H9BrN4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-CUHNJ1 WO2024039689-A1_208 N-(3-cyano-4-fluoro-1H-indol-7-yl)-2-(difluoromethyl)-1,3-thiazole-5-sulfonamide N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(C(F)F)s3)ccc(F)c12 Degrader C13H7F3N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-4I7LBZ N-(3-cyano-1H-indol-7-yl)-2-propan-2-yl-1,3-thiazole-5-sulfonamide 0 CC(C)c1ncc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)s1 Degrader C15H14N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-UG8NWJ WO2024039689-A1_21 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-methyl-4-pyridazin-4-yl-1,3-thiazole-2-sulfonamide Cc1sc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)nc1-c1ccnnc1 Degrader C18H14N6O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-GTN0KP N-(3-cyano-1H-indol-7-yl)-2-cyclopropyl-1,3-thiazole-5-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(C4CC4)s3)cccc12 Degrader C15H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-SCLJ3G N-(3-cyano-1H-indol-7-yl)-2,4-dimethyl-1,3-thiazole-5-sulfonamide 0 Cc1nc(C)c(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)s1 Degrader C14H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-5WS4W8 WO2024039689-A1_212 N-(3-chloro-4-fluoro-1H-indol-7-yl)-2-(difluoromethyl)-1,3-thiazole-5-sulfonamide O=S(=O)(Nc1ccc(F)c2c(Cl)c[nH]c12)c1cnc(C(F)F)s1 Degrader C12H7ClF3N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-7Z764H N-(3-cyano-1H-indol-7-yl)-1,3,4-thiadiazole-2-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3nncs3)cccc12 Degrader C11H7N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-JS8ISK N-(3-cyano-1H-indol-7-yl)-1,2-thiazole-5-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3ccns3)cccc12 Degrader C12H8N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-5PQL2H N-(3-cyano-1H-indol-7-yl)-1,2-thiazole-4-sulfonamide BDBM659557; US20240092770, Compound 215 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnsc3)cccc12 Degrader C12H8N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-X6N0H7 N-(3-cyano-4-ethyl-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide SCHEMBL27174925 CCc1ccc(NS(=O)(=O)c2nccs2)c2[nH]cc(C#N)c12 Degrader C14H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-B7MV5H N-(3-cyano-4-ethyl-1H-indol-7-yl)-1,3-thiazole-5-sulfonamide 0 CCc1ccc(NS(=O)(=O)c2cncs2)c2[nH]cc(C#N)c12 Degrader C14H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-XRH5ZJ WO2024039689-A1_218 N-(3-cyano-4-fluoro-1H-indol-7-yl)-2-morpholin-4-yl-1,3-thiazole-5-sulfonamide N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(N4CCOCC4)s3)ccc(F)c12 Degrader C16H14FN5O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-Z8O0CE N-(3-cyano-1H-indol-7-yl)-2-(fluoromethyl)-1,3-thiazole-5-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(CF)s3)cccc12 Degrader C13H9FN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-ZZVF93 WO2024039689-A1_22 . Cc1ccc(NS(=O)(=O)c2nc(-c3cc[nH]n3)cs2)c2[nH]cc(C#N)c12 Degrader C16H12N6O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-URSNE0 N-(3-cyano-1H-indol-7-yl)-2-methoxy-1,3-thiazole-4-sulfonamide 0 COc1nc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)cs1 Degrader C13H10N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-9QZZ8H WO2024039689-A1_221 N-(3-cyano-4-methyl-1H-indol-7-yl)-2-methoxy-1,3-thiazole-4-sulfonamide COc1nc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cs1 Degrader C14H12N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-RVT9VK WO2024039689-A1_222 N-(3-cyano-4-methyl-1H-indol-7-yl)-4-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-sulfonamide Cc1ccc(NS(=O)(=O)c2nc(CC(C)(C)O)cs2)c2[nH]cc(C#N)c12 Degrader C17H18N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-ETH4V6 N-(3-cyano-1H-indol-7-yl)-5-fluoro-1,3-thiazole-2-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3ncc(F)s3)cccc12 Degrader C12H7FN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-UHUWFA N-(3-cyano-4-methyl-1H-indol-7-yl)-5-fluoro-1,3-thiazole-2-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2ncc(F)s2)c2[nH]cc(C#N)c12 Degrader C13H9FN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-TNXB5K N-(3-cyano-1H-indol-7-yl)-2-cyclopropyl-1,3-thiazole-4-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3csc(C4CC4)n3)cccc12 Degrader C15H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-C8LRWI N-(3-cyano-1H-indol-7-yl)-2-ethyl-1,3-oxazole-4-sulfonamide 0 CCc1nc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)co1 Degrader C14H12N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-G1EA4W N-(3-cyano-1H-indol-7-yl)-2-cyclopropyl-1,3-oxazole-4-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3coc(C4CC4)n3)cccc12 Degrader C15H12N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-42508N WO2024039689-A1_228 N-(3-cyano-4-methyl-1H-indol-7-yl)-2-cyclopropyl-1,3-thiazole-4-sulfonamide Cc1ccc(NS(=O)(=O)c2csc(C3CC3)n2)c2[nH]cc(C#N)c12 Degrader C16H14N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-4EF7JF N-(3-cyano-4-methyl-1H-indol-7-yl)-2-ethyl-1,3-oxazole-4-sulfonamide 0 CCc1nc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)co1 Degrader C15H14N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-GPOHIN SCHEMBL27174886 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-morpholin-4-yl-1,3-thiazole-2-sulfonamide\; SCHEMBL27174886 Cc1ccc(NS(=O)(=O)c2ncc(N3CCOCC3)s2)c2[nH]cc(C#N)c12 Degrader C17H17N5O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-NWRZW1 WO2024039689-A1_230 N-(3-cyano-4-methyl-1H-indol-7-yl)-2-cyclopropyl-1,3-oxazole-4-sulfonamide Cc1ccc(NS(=O)(=O)c2coc(C3CC3)n2)c2[nH]cc(C#N)c12 Degrader C16H14N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-QCPTTS WO2024039689-A1_231 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-sulfonamide Cc1ccc(NS(=O)(=O)c2ncc(CC(C)(C)O)s2)c2[nH]cc(C#N)c12 Degrader C17H18N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-1MKHPZ N-(3-cyano-1H-indol-7-yl)-2-ethyl-1,3-thiazole-4-sulfonamide 0 CCc1nc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)cs1 Degrader C14H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-L2FO1U N-(3-cyano-4-methyl-1H-indol-7-yl)-2-ethyl-1,3-thiazole-4-sulfonamide 0 CCc1nc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cs1 Degrader C15H14N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-5BOIJB N-(3-cyano-4-fluoro-1H-indol-7-yl)-1,2-thiazole-4-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnsc3)ccc(F)c12 Degrader C12H7FN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-8JPOWR N-(3-chloro-4-fluoro-1H-indol-7-yl)-1,2-thiazole-4-sulfonamide 0 O=S(=O)(Nc1ccc(F)c2c(Cl)c[nH]c12)c1cnsc1 Degrader C11H7ClFN3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-F5CWBG N-(3-chloro-1H-indol-7-yl)-1,2-thiazole-4-sulfonamide 0 O=S(=O)(Nc1cccc2c(Cl)c[nH]c12)c1cnsc1 Degrader C11H8ClN3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-I1CMXP N-(3-cyano-4-methyl-1H-indol-7-yl)-1,2-thiazole-4-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2cnsc2)c2[nH]cc(C#N)c12 Degrader C13H10N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-3BTEBA N-(3-chloro-2H-indazol-7-yl)-1,3-thiazole-5-sulfonamide 0 O=S(=O)(Nc1cccc2c(Cl)n[nH]c12)c1cncs1 Degrader C10H7ClN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-RVREPO N-(3-cyano-1H-indol-7-yl)-2-fluoro-1,3-thiazole-5-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(F)s3)cccc12 Degrader C12H7FN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-SJS40L US20240092770, Compound 24 N-(3-cyano-4-methyl-1H-indol-7-yl)-2-(trifluoromethyl)-1,3-thiazole-5-sulfonamide\; BDBM659436; US20240092770, Compound 24 Cc1ccc(NS(=O)(=O)c2cnc(C(F)(F)F)s2)c2[nH]cc(C#N)c12 Degrader C14H9F3N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-RTF6IT N-(3-cyano-1H-indol-7-yl)-2-methyl-1,3-oxazole-4-sulfonamide 0 Cc1nc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)co1 Degrader C13H10N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-AQQFG1 N-(3-cyano-4-methyl-1H-indol-7-yl)-2-methyl-1,3-oxazole-4-sulfonamide 0 Cc1nc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)co1 Degrader C14H12N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-TTITBP N-(3-chloro-2H-indazol-7-yl)-2-methyl-1,3-thiazole-5-sulfonamide 0 Cc1ncc(S(=O)(=O)Nc2cccc3c(Cl)n[nH]c23)s1 Degrader C11H9ClN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-WA7BCP N-(3-chloro-2H-indazol-7-yl)-1,2-thiazole-4-sulfonamide 0 O=S(=O)(Nc1cccc2c(Cl)n[nH]c12)c1cnsc1 Degrader C10H7ClN4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-XLEUG7 N-(3-cyano-1H-indazol-7-yl)-1,3-thiazole-5-sulfonamide SCHEMBL27174874 N#Cc1n[nH]c2c(NS(=O)(=O)c3cncs3)cccc12 Degrader C11H7N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-P3MKN5 WO2024039689-A1_245 . Cc1ncc(S(=O)(=O)Nc2cccc3c(C#N)n[nH]c23)s1 Degrader C12H9N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-HK6LF9 N-(3-cyano-1H-indazol-7-yl)-1,2-thiazole-4-sulfonamide 0 N#Cc1n[nH]c2c(NS(=O)(=O)c3cnsc3)cccc12 Degrader C11H7N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-YJ6Q8S N-(3-cyano-4-fluoro-1H-indazol-7-yl)-1,3-thiazole-5-sulfonamide 0 N#Cc1n[nH]c2c(NS(=O)(=O)c3cncs3)ccc(F)c12 Degrader C11H6FN5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-9T89X3 WO2024039689-A1_248 N-(3-cyano-4-fluoro-1H-indazol-7-yl)-2-methyl-1,3-thiazole-5-sulfonamide Cc1ncc(S(=O)(=O)Nc2ccc(F)c3c(C#N)n[nH]c23)s1 Degrader C12H8FN5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-USGMFC N-[3-(trifluoromethyl)-1H-indol-7-yl]-1,2-thiazole-4-sulfonamide 0 O=S(=O)(Nc1cccc2c(C(F)(F)F)c[nH]c12)c1cnsc1 Degrader C12H8F3N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-9301T1 US20240092770, Compound 25 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-(trifluoromethyl)-1,3-thiazole-2-sulfonamide\; BDBM659437; US20240092770, Compound 25 Cc1ccc(NS(=O)(=O)c2ncc(C(F)(F)F)s2)c2[nH]cc(C#N)c12 Degrader C14H9F3N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-BZ34O7 N-(3-cyano-4-methyl-1H-indol-7-yl)-1,3-oxazole-5-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2cnco2)c2[nH]cc(C#N)c12 Degrader C13H10N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-OVGWXP N-(3-cyano-1H-indol-7-yl)-1,3-oxazole-5-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnco3)cccc12 Degrader C12H8N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-TY4W95 WO2024039689-A1_253 . Cc1ccc(NS(=O)(=O)c2cn3c(n2)CCCC3)c2[nH]cc(C#N)c12 Degrader C17H17N5O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-3VWDOL N-(3-cyano-1H-indol-7-yl)-1,2,5-thiadiazole-3-sulfonamide BDBM659558; US20240092770, Compound 254 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnsn3)cccc12 Degrader C11H7N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-T36IWJ N-(3-cyano-1H-indol-7-yl)thiadiazole-5-sulfonamide BDBM659559; US20240092770, Compound 255 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnns3)cccc12 Degrader C11H7N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-6Y2Q1W N-(3-cyano-1H-indol-7-yl)-3-methyl-1,2-thiazole-5-sulfonamide SCHEMBL27174906 Cc1cc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)sn1 Degrader C13H10N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-B7DKFR N-(3-cyano-4-methyl-1H-indol-7-yl)-3-methyl-1,2-thiazole-5-sulfonamide 0 Cc1cc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)sn1 Degrader C14H12N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-NH9K0P N-(3-cyano-1H-indol-7-yl)-3-methyl-1,2-thiazole-4-sulfonamide 0 Cc1nscc1S(=O)(=O)Nc1cccc2c(C#N)c[nH]c12 Degrader C13H10N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-Y4JGXP N-(3-cyano-4-methyl-1H-indol-7-yl)-1,2,5-thiadiazole-3-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2cnsn2)c2[nH]cc(C#N)c12 Degrader C12H9N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-1QP0V6 WO2024039689-A1_26 . Cc1ccc(NS(=O)(=O)c2nc(-c3cn[nH]c3)cs2)c2[nH]cc(C#N)c12 Degrader C16H12N6O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-KGFZUV N-(3-cyano-4-methyl-1H-indol-7-yl)thiadiazole-5-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2cnns2)c2[nH]cc(C#N)c12 Degrader C12H9N5O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-5715QZ N-(3-cyano-4-methyl-1H-indol-7-yl)-1,2-thiazole-5-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2ccns2)c2[nH]cc(C#N)c12 Degrader C13H10N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-G0176D N-(3-cyano-1H-indol-7-yl)furan-3-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3ccoc3)cccc12 Degrader C13H9N3O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-B1YIH6 N-(3-cyano-4-methyl-1H-indol-7-yl)furan-3-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2ccoc2)c2[nH]cc(C#N)c12 Degrader C14H11N3O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-11HKP7 N-(3-chloro-4-fluoro-1H-indol-7-yl)-2-ethyl-1,3-oxazole-5-sulfonamide 0 CCc1ncc(S(=O)(=O)Nc2ccc(F)c3c(Cl)c[nH]c23)o1 Degrader C13H11ClFN3O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-FKN1H8 N-(3-chloro-1H-indol-7-yl)-2-ethyl-1,3-oxazole-5-sulfonamide 0 CCc1ncc(S(=O)(=O)Nc2cccc3c(Cl)c[nH]c23)o1 Degrader C13H12ClN3O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-V2U3QM N-(3-cyano-1H-indol-7-yl)thiophene-2-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3cccs3)cccc12 Degrader C13H9N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-F6SST1 N-(3-cyano-1H-indol-7-yl)thiophene-3-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3ccsc3)cccc12 Degrader C13H9N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-8WAVDE N-(3-cyano-4-methyl-1H-indol-7-yl)thiophene-2-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2cccs2)c2[nH]cc(C#N)c12 Degrader C14H11N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-XOCIO3 N-(3-cyano-4-methyl-1H-indol-7-yl)thiophene-3-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2ccsc2)c2[nH]cc(C#N)c12 Degrader C14H11N3O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-6YRYZB N-(3-cyano-1H-indol-7-yl)-1,3-thiazole-2-sulfonamide BDBM659438; US20240092770, Compound 27 N#Cc1c[nH]c2c(NS(=O)(=O)c3nccs3)cccc12 Degrader C12H8N4O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-IW2XMK N-(3-cyano-1H-indol-7-yl)-1,3,4-oxadiazole-2-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3nnco3)cccc12 Degrader C11H7N5O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-D26UMB N-(3-cyano-4-methyl-1H-indol-7-yl)-1,3,4-oxadiazole-2-sulfonamide 0 Cc1ccc(NS(=O)(=O)c2nnco2)c2[nH]cc(C#N)c12 Degrader C12H9N5O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-LDGZTA WO2024039689-A1_272 . O=S(=O)(Nc1cccc2c(C(F)(F)F)c[nH]c12)c1cnco1 Degrader C12H8F3N3O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-YKDR5R WO2024039689-A1_273 . CCc1ncc(S(=O)(=O)Nc2ccc(F)c3c(C#N)c[nH]c23)o1 Degrader C14H11FN4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-G0L5CM WO2024039689-A1_274 . Cc1ncc(S(=O)(=O)Nc2ccc(F)c3c(Cl)c[nH]c23)o1 Degrader C12H9ClFN3O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-HZAFLE WO2024039689-A1_275 . Cc1ncc(S(=O)(=O)Nc2cccc3c(Cl)c[nH]c23)o1 Degrader C12H10ClN3O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-ZFWX53 WO2024039689-A1_276 . CC(C)(O)Cc1ncc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)s1 Degrader C16H16N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-JQ4DY8 N-(3-cyano-1H-indol-7-yl)-1,2-oxazole-4-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3cnoc3)cccc12 Degrader C12H8N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-Y66ZXS WO2024039689-A1_278 N-(3-cyano-4-methyl-1H-indol-7-yl)-2-(2-hydroxy-2-methylpropyl)-1,3-thiazole-5-sulfonamide Cc1ccc(NS(=O)(=O)c2cnc(CC(C)(C)O)s2)c2[nH]cc(C#N)c12 Degrader C17H18N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-5WZT3I N-(3-cyano-4-fluoro-1H-indol-7-yl)-2-methyl-1,3-oxazole-5-sulfonamide 0 Cc1ncc(S(=O)(=O)Nc2ccc(F)c3c(C#N)c[nH]c23)o1 Degrader C13H9FN4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-G8KHTC WO2024039689-A1_28 N-(3-cyano-4-methyl-1H-indol-7-yl)-5-methyl-4-(1H-pyrazol-5-yl)-1,3-thiazole-2-sulfonamide Cc1sc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)nc1-c1cc[nH]n1 Degrader C17H14N6O2S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-PCBA9K N-(3-cyano-1H-indol-7-yl)furan-2-sulfonamide SCHEMBL3065754 N#Cc1c[nH]c2c(NS(=O)(=O)c3ccco3)cccc12 Degrader C13H9N3O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-AF9M24 WO2024039689-A1_281 . Cc1ccc(NS(=O)(=O)c2ccco2)c2[nH]cc(C#N)c12 Degrader C14H11N3O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-IIBMEL WO2024039689-A1_282 . COc1ccc(NS(=O)(=O)c2cnsc2)c2[nH]cc(C#N)c12 Degrader C13H10N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-MAIXGQ WO2024039689-A1_283 . Cc1ccc(NS(=O)(=O)c2cnoc2)c2[nH]cc(C#N)c12 Degrader C13H10N4O3S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-R6ITTV N-(3-cyano-1H-indol-7-yl)-1H-pyrrole-2-sulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3ccc[nH]3)cccc12 Degrader C13H10N4O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-P8KLZ7 WO2024039689-A1_285 . N#Cc1c[nH]c2c(NS(=O)(=O)c3cc[nH]c3)cccc12 Degrader C13H10N4O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-R7RI21 WO2024039689-A1_286 . Cc1ccc(NS(=O)(=O)c2cc[nH]c2)c2[nH]cc(C#N)c12 Degrader C14H12N4O2S RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-ZFD9ET WO2024039689-A1_287 . COc1cc(NS(=O)(=O)c2cncs2)c2[nH]cc(C#N)c2c1 Degrader C13H10N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-WE7NB3 WO2024039689-A1_288 . COc1ccc(NS(=O)(=O)c2cncs2)c2[nH]cc(C#N)c12 Degrader C13H10N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-X1VTI7 WO2024039689-A1_289 . COc1ccc(NS(=O)(=O)c2nccs2)c2[nH]cc(C#N)c12 Degrader C13H10N4O3S2 RBM39 Q14498 DCAF15 WO-2024039689-A1 TPD-L8JMBY CHEMBL5432743 3-benzoyl-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]benzamide\; CHEMBL5432743; SCHEMBL27387088 O=C1CCC(N2Cc3cc(NC(=O)c4cccc(C(=O)c5ccccc5)c4)ccc3C2=O)C(=O)N1 Degrader C27H21N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-Y7A93K CHEMBL5438061 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2H-chromene-3-carboxamide\; CHEMBL5438061; SCHEMBL27387019 O=C1CCC(N2Cc3cc(NC(=O)C4=Cc5ccccc5OC4)ccc3C2=O)C(=O)N1 Degrader C23H19N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-RX11GO CHEMBL5408856 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide\; CHEMBL5408856; SCHEMBL27387091 O=C1CCC(N2Cc3cc(NC(=O)c4ccc5c(c4)OCCO5)ccc3C2=O)C(=O)N1 Degrader C22H19N3O6 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-OPCTPQ CHEMBL5424426 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1,3-benzodioxole-5-carboxamide\; CHEMBL5424426; SCHEMBL27387094 O=C1CCC(N2Cc3cc(NC(=O)c4ccc5c(c4)OCO5)ccc3C2=O)C(=O)N1 Degrader C21H17N3O6 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-O5HN8Y CHEMBL5417912 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-phenoxybenzamide\; CHEMBL5417912; SCHEMBL27387095 O=C1CCC(N2Cc3cc(NC(=O)c4cccc(Oc5ccccc5)c4)ccc3C2=O)C(=O)N1 Degrader C26H21N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-TCNLE6 CHEMBL5394470 (E)-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-phenylprop-2-enamide\; CHEMBL5394470; SCHEMBL27387097 O=C(/C=C/c1ccccc1)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C22H19N3O4 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-GG2P2F SCHEMBL27387099 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-(4-methoxyphenyl)propanamide\; SCHEMBL27387099 COc1ccc(CCC(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C23H23N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-TNL5DU SCHEMBL27387102 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-(6-methoxynaphthalen-1-yl)acetamide\; SCHEMBL27387102 COc1ccc2c(CC(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cccc2c1 Degrader C26H23N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-EAO8D2 CHEMBL5394952 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1-benzofuran-2-carboxamide\; CHEMBL5394952; SCHEMBL27387106 O=C1CCC(N2Cc3cc(NC(=O)c4cc5ccccc5o4)ccc3C2=O)C(=O)N1 Degrader C22H17N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-B20NL7 SCHEMBL27387107 (E)-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-(4-methoxyphenyl)prop-2-enamide\; SCHEMBL27387107 COc1ccc(/C=C/C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C23H21N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-TMB9RD CHEMBL5412554 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-phenoxybenzamide\; CHEMBL5412554; SCHEMBL27387109 O=C1CCC(N2Cc3cc(NC(=O)c4ccc(Oc5ccccc5)cc4)ccc3C2=O)C(=O)N1 Degrader C26H21N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-KQKT1U CHEMBL5406290 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1-benzofuran-5-carboxamide\; CHEMBL5406290; SCHEMBL27387113 O=C1CCC(N2Cc3cc(NC(=O)c4ccc5occc5c4)ccc3C2=O)C(=O)N1 Degrader C22H17N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-6RE7BN CHEMBL5417902 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1,4-benzodioxine-3-carboxamide\; CHEMBL5417902; SCHEMBL27387184 O=C1CCC(N2Cc3cc(NC(=O)C4=COc5ccccc5O4)ccc3C2=O)C(=O)N1 Degrader C22H17N3O6 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-HIKZV9 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]benzamide CHEMBL5401836; SCHEMBL27387190 O=C1CCC(N2Cc3cc(NC(=O)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C20H17N3O4 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-T6NUDG SCHEMBL27387199 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1,3-benzothiazole-2-carboxamide\; SCHEMBL27387199 O=C1CCC(N2Cc3cc(NC(=O)c4nc5ccccc5s4)ccc3C2=O)C(=O)N1 Degrader C21H16N4O4S CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-VWMA9G N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-5-yl]acetamide CHEMBL5439738; SCHEMBL23535299; N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-5-yl]acetamide; 2651996-37-9 CC(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C15H15N3O4 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-HUI2A3 CHEMBL5417251 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-naphthalen-1-ylacetamide\; CHEMBL5417251; SCHEMBL27387204 O=C1CCC(N2Cc3cc(NC(=O)Cc4cccc5ccccc45)ccc3C2=O)C(=O)N1 Degrader C25H21N3O4 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-USC1AK SCHEMBL27387207 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-(7-methoxynaphthalen-1-yl)acetamide\; SCHEMBL27387207 COc1ccc2cccc(CC(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)c2c1 Degrader C26H23N3O5 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-9PWPHI WO2024059107-A1_69 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-3-(4-methoxyphenoxy)benzamide COc1ccc(Oc2cccc(C(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)c2)cc1 Degrader C27H23N3O6 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-IJAJ3R WO2024059107-A1_70 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-(4-methoxyphenoxy)benzamide COc1ccc(Oc2ccc(C(=O)Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc2)cc1 Degrader C27H23N3O6 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-3ISVAI SCHEMBL27387210 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2-naphthalen-2-ylacetamide\; SCHEMBL27387210 O=C1CCC(N2Cc3cc(NC(=O)Cc4ccc5ccccc5c4)ccc3C2=O)C(=O)N1 Degrader C25H21N3O4 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-7J120Y CHEMBL5411150 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-1,3-benzothiazole-6-carboxamide\; CHEMBL5411150; SCHEMBL27387216 O=C1CCC(N2Cc3cc(NC(=O)c4ccc5ncsc5c4)ccc3C2=O)C(=O)N1 Degrader C21H16N4O4S CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-02571A SCHEMBL27387221 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-phenylsulfanylbenzamide\; SCHEMBL27387221 O=C1CCC(N2Cc3cc(NC(=O)c4ccc(Sc5ccccc5)cc4)ccc3C2=O)C(=O)N1 Degrader C26H21N3O4S CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-2MFR70 CHEMBL5441130 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-7-methoxy-2H-chromene-3-carboxamide\; CHEMBL5441130; SCHEMBL27387225; BDBM50631523 COc1ccc2c(c1)OCC(C(=O)Nc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)=C2 Degrader C24H21N3O6 CK1α;IKZF1;IKZF3;GSPT1 P48729/Q13422/Q9UKT9/P15170 CRBN WO-2024059107-A1 TPD-LFN6D0 WO2024066454A1_C1 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NCCNC3=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)CC[C@@]21[H] Degrader C34H41N5O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-VH8DQ0 WO2024066454A1_C10 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NCCCCCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)CC[C@@]21[H] Degrader C38H49N5O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-ERZW9S WO2024066454A1_C11 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NCCCCCCCNC3=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)CC[C@@]21[H] Degrader C39H51N5O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-8KNVWI WO2024066454A1_C12 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NCCCCCCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)CC[C@@]21[H] Degrader C39H51N5O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-TDAGCR WO2024066454A1_C13 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)N3CCC(CN4CCN(C5=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=CC=C5)CC4)CC3)CC[C@@]21[H] Degrader C42H54N6O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-GVGHLI WO2024066454A1_C14 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)N3CCC(CN4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)CC[C@@]21[H] Degrader C42H54N6O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-X5OPPJ WO2024066454A1_C15 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C40H45N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-MGXQ2Q WO2024066454A1_C16 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C40H45N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-JK2W52 WO2024066454A1_C17 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C41H47N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-ARWONA WO2024066454A1_C18 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCNC4=CC5=C(C=C4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C41H47N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-PT3ME9 WO2024066454A1_C19 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C43H51N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-X8S4O3 WO2024066454A1_C2 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NCCNC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC[C@@]21[H] Degrader C34H41N5O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-JNZVLS WO2024066454A1_C20 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCCCNC4=CC5=C(C=C4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C43H51N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-S74KU4 WO2024066454A1_C21 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C44H53N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-7W0HD6 WO2024066454A1_C22 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCCCCNC4=CC5=C(C=C4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C44H53N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-MFW0G9 WO2024066454A1_C23 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C45H55N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-RHVDK2 WO2024066454A1_C24 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCCCCCNC4=CC5=C(C=C4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C45H55N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-47ESUE WO2024066454A1_C25 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C46H57N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-EA87SU WO2024066454A1_C26 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=C(OCCCCCCCCNC4=CC5=C(C=C4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)CC[C@@]21[H] Degrader C46H57N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-NEDYQ3 WO2024066454A1_C27 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCNC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)=C3)CC[C@@]21[H] Degrader C40H45N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-66E14F WO2024066454A1_C28 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)=C3)CC[C@@]21[H] Degrader C40H45N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-91BZW9 WO2024066454A1_C29 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCNC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)=C3)CC[C@@]21[H] Degrader C41H47N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-6FLM2C WO2024066454A1_C3 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC[C@@]21[H] Degrader C35H43N5O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-U2SKU5 WO2024066454A1_C30 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)=C3)CC[C@@]21[H] Degrader C41H47N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-ZP6KGO WO2024066454A1_C31 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCNC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)=C3)CC[C@@]21[H] Degrader C42H49N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-OHZQQX WO2024066454A1_C32 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)=C3)CC[C@@]21[H] Degrader C42H49N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-JV9MHW WO2024066454A1_C33 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCCNC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)=C3)CC[C@@]21[H] Degrader C43H51N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-D0RVWV WO2024066454A1_C34 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)=C3)CC[C@@]21[H] Degrader C43H51N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-7PTRG4 WO2024066454A1_C35 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCCCNC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)=C3)CC[C@@]21[H] Degrader C44H53N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-0QJ9OZ WO2024066454A1_C36 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)=C3)CC[C@@]21[H] Degrader C44H53N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-MOPLZP WO2024066454A1_C37 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCCCCNC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)=C3)CC[C@@]21[H] Degrader C45H55N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-RHF6QO WO2024066454A1_C38 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)=C3)CC[C@@]21[H] Degrader C45H55N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-UCUXCS WO2024066454A1_C39 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCCCCCNC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)=C3)CC[C@@]21[H] Degrader C46H57N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-GLQDBO WO2024066454A1_C4 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NCCCNC3=C/C=C4/C(=O)N(C5CCC(=O)NC5=O)C(=O)/C4=C\3)CC[C@@]21[H] Degrader C35H43N5O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-FC7ASY WO2024066454A1_C40 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)=C3)CC[C@@]21[H] Degrader C46H57N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-1R79I2 WO2024066454A1_C41 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCCCNC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)=C3)CC[C@@]21[H] Degrader C41H49N5O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-5CN5LM WO2024066454A1_C42 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCC4CCN(C5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=C3)CC[C@@]21[H] Degrader C44H51N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-HT3DVJ WO2024066454A1_C43 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(OCC4CCN(C5=C/C6=C(\C=C/5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=C3)CC[C@@]21[H] Degrader C44H51N5O7 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-FWTZD3 WO2024066454A1_C44 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(N4CCC(CN5CCN(/C6=C/C=C\C7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)=C3)CC[C@@]21[H] Degrader C48H59N7O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-9E1K1I WO2024066454A1_C45 . [H][C@@]12CC[C@@]3([H])NC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(=O)NC3=CC=CC(N4CCC(CN5CCN(C6=CC7=C(C=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)=C3)CC[C@@]21[H] Degrader C48H59N7O6 GSPT1 P15170 CRBN WO-2024066454-A1 TPD-QAKP4H 2-(2,6-Dioxopiperidin-3-yl)-5-piperidin-2-ylisoindole-1,3-dione SCHEMBL27284246 O=C1CCC(N2C(=O)c3ccc(C4CCCCN4)cc3C2=O)C(=O)N1 Degrader C18H19N3O4 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-X0MNSY 3-[3-oxo-6-[(2S)-piperidin-2-yl]-1H-isoindol-2-yl]piperidine-2,6-dione SCHEMBL27284748 O=C1CCC(N2Cc3cc([C@@H]4CCCCN4)ccc3C2=O)C(=O)N1 Degrader C18H21N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-Z1ZHTE SCHEMBL27283351 3-[3-oxo-6-[5-(trifluoromethyl)pyridin-2-yl]-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27283351 O=C1CCC(N2Cc3cc(-c4ccc(C(F)(F)F)cn4)ccc3C2=O)C(=O)N1 Degrader C19H14F3N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-HDWLJP SCHEMBL27283242 3-(7-methyl-3-oxo-6-piperidin-2-yl-1H-isoindol-2-yl)piperidine-2,6-dione\; SCHEMBL27283242 Cc1c(C2CCCCN2)ccc2c1CN(C1CCC(=O)NC1=O)C2=O Degrader C19H23N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-DGC2B7 3-(1-Oxo-5-(pyridin-2-yl)isoindolin-2-yl)piperidine-2,6-dione SCHEMBL23423465; DB-409986; 3-(1-oxo-5-(pyridin-2-yl)isoindolin-2-yl)piperidine-2,6-dione; 2710288-40-5 O=C1CCC(N2Cc3cc(-c4ccccn4)ccc3C2=O)C(=O)N1 Degrader C18H15N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-LKQWTD 3-(3-oxo-6-piperidin-2-yl-1H-isoindol-2-yl)piperidine-2,6-dione SCHEMBL27283139 O=C1CCC(N2Cc3cc(C4CCCCN4)ccc3C2=O)C(=O)N1 Degrader C18H21N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-BAPCCU SCHEMBL27283244 3-(5-methyl-3-oxo-6-piperidin-2-yl-1H-isoindol-2-yl)piperidine-2,6-dione\; SCHEMBL27283244 Cc1cc2c(cc1C1CCCCN1)CN(C1CCC(=O)NC1=O)C2=O Degrader C19H23N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-X8EEAB SCHEMBL27283245 3-(4-methyl-3-oxo-6-piperidin-2-yl-1H-isoindol-2-yl)piperidine-2,6-dione\; SCHEMBL27283245 Cc1cc(C2CCCCN2)cc2c1C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C19H23N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-GKFSY0 SCHEMBL27283247 3-(7-fluoro-3-oxo-6-piperidin-2-yl-1H-isoindol-2-yl)piperidine-2,6-dione\; SCHEMBL27283247 O=C1CCC(N2Cc3c(ccc(C4CCCCN4)c3F)C2=O)C(=O)N1 Degrader C18H20FN3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-N31VIP 3-(2-Oxo-5-pyridin-2-ylbenzo[cd]indol-1-yl)piperidine-2,6-dione SCHEMBL27283346 O=C1CCC(N2C(=O)c3ccc(-c4ccccn4)c4cccc2c34)C(=O)N1 Degrader C21H15N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-DPQ7RZ SCHEMBL27283249 3-(5-fluoro-3-oxo-6-piperidin-2-yl-1H-isoindol-2-yl)piperidine-2,6-dione\; SCHEMBL27283249 O=C1CCC(N2Cc3cc(C4CCCCN4)c(F)cc3C2=O)C(=O)N1 Degrader C18H20FN3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-S4Z157 3-(1-methyl-3-oxo-6-pyridin-2-yl-1H-isoindol-2-yl)piperidine-2,6-dione SCHEMBL27284904 CC1c2cc(-c3ccccn3)ccc2C(=O)N1C1CCC(=O)NC1=O Degrader C19H17N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-VE8WV9 SCHEMBL27283250 3-(4-fluoro-3-oxo-6-piperidin-2-yl-1H-isoindol-2-yl)piperidine-2,6-dione\; SCHEMBL27283250 O=C1CCC(N2Cc3cc(C4CCCCN4)cc(F)c3C2=O)C(=O)N1 Degrader C18H20FN3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-3CI209 Z4504065320 3-[6-(5-methoxypyridin-2-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27388047; Z4504065320 COc1ccc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)nc1 Degrader C19H17N3O4 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-QZT4M1 SCHEMBL27283251 3-(1-methyl-3-oxo-6-piperidin-2-yl-1H-isoindol-2-yl)piperidine-2,6-dione\; SCHEMBL27283251 CC1c2cc(C3CCCCN3)ccc2C(=O)N1C1CCC(=O)NC1=O Degrader C19H23N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-M235IM Z4504065055 3-[3-oxo-6-[4-(trifluoromethyl)pyridin-2-yl]-1H-isoindol-2-yl]piperidine-2,6-dione\; Z4504065055 O=C1CCC(N2Cc3cc(-c4cc(C(F)(F)F)ccn4)ccc3C2=O)C(=O)N1 Degrader C19H14F3N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-VKFLRI SCHEMBL27388048 3-[3-oxo-6-(4-oxo-1H-pyridin-2-yl)-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27388048 O=C1CCC(N2Cc3cc(-c4cc(O)ccn4)ccc3C2=O)C(=O)N1 Degrader C18H15N3O4 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-IQBBB7 3-(2-Oxo-6-pyridin-2-ylbenzo[cd]indol-1-yl)piperidine-2,6-dione SCHEMBL27388050 O=C1CCC(N2C(=O)c3cccc4c(-c5ccccn5)ccc2c34)C(=O)N1 Degrader C21H15N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-8F4SBW 3-(3-oxo-6-pyridin-2-yl-1H-isoindol-2-yl)azepane-2,7-dione SCHEMBL27388053 O=C1CCCC(N2Cc3cc(-c4ccccn4)ccc3C2=O)C(=O)N1 Degrader C19H17N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-480NDU SCHEMBL27388057 3-(6-oxo-2-pyridin-2-yl-4H-thieno[2,3-c]pyrrol-5-yl)piperidine-2,6-dione\; SCHEMBL27388057 O=C1CCC(N2Cc3cc(-c4ccccn4)sc3C2=O)C(=O)N1 Degrader C16H13N3O3S NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-158AP2 SCHEMBL27388058 3-(6-oxo-3-pyridin-2-yl-4H-thieno[3,4-c]pyrrol-5-yl)piperidine-2,6-dione\; SCHEMBL27388058 O=C1CCC(N2Cc3c(csc3-c3ccccn3)C2=O)C(=O)N1 Degrader C16H13N3O3S NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-2QL325 SCHEMBL27283253 3-[3-oxo-6-(5-phenylpiperidin-2-yl)-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27283253 O=C1CCC(N2Cc3cc(C4CCC(c5ccccc5)CN4)ccc3C2=O)C(=O)N1 Degrader C24H25N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-DL7KSY SCHEMBL27283256 N-[6-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-3-yl]acetamide\; SCHEMBL27283256 CC(=O)NC1CCC(c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)NC1 Degrader C20H24N4O4 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-CD2877 SCHEMBL27283339 3-[6-(5-benzylpiperidin-2-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27283339 O=C1CCC(N2Cc3cc(C4CCC(Cc5ccccc5)CN4)ccc3C2=O)C(=O)N1 Degrader C25H27N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-RMQPFU SCHEMBL27283341 3-[6-(5-butylpiperidin-2-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27283341 CCCCC1CCC(c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)NC1 Degrader C22H29N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-PNQZ2G SCHEMBL27283347 3-[3-oxo-6-(5-phenylpyridin-2-yl)-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27283347 O=C1CCC(N2Cc3cc(-c4ccc(-c5ccccc5)cn4)ccc3C2=O)C(=O)N1 Degrader C24H19N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-F1GX5N SCHEMBL27283343 3-[6-(6-butylpiperidin-2-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione\; SCHEMBL27283343 CCCCC1CCCC(c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)N1 Degrader C22H29N3O3 NEK7 Q8TDX7 CRBN WO-2024094819-A1 TPD-1BGP4U N-(3-cyano-4-methyl-1H-indol-7-yl)-4-pyridin-3-ylbenzenesulfonamide SCHEMBL27284391 Cc1ccc(NS(=O)(=O)c2ccc(-c3cccnc3)cc2)c2[nH]cc(C#N)c12 Degrader C21H16N4O2S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-N523CW WO2024129634-A1_100 . N#Cc1c[nH]c2c(NS(=O)(=O)c3ccc(O)cc3)ccc(F)c12 Degrader C15H10FN3O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-HTZ73F WO2024129634-A1_101 . CC(C)(O)COc1ccc(S(=O)(=O)Nc2cccc3c(C#N)n[nH]c23)cc1 Degrader C18H18N4O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-2X94M0 WO2024129634-A1_102 . N#Cc1c[nH]c2c(NS(=O)(=O)c3cnc(O)nc3)cccc12 Degrader C13H9N5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-49EA9O WO2024129634-A1_103 . CC(C)(O)COc1ccc(S(=O)(=O)Nc2ccc(Cl)c3c(Cl)c[nH]c23)cc1 Degrader C18H18Cl2N2O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-DZYSDN WO2024129634-A1_104 . N#Cc1c[nH]c2c(NS(=O)(=O)c3ccc(-c4noc(O)n4)cc3)cccc12 Degrader C17H11N5O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-KIYLEA SCHEMBL27283684 N-(3-cyano-1H-indol-7-yl)-4-(2-oxo-3H-1,3,4-oxadiazol-5-yl)benzenesulfonamide\; SCHEMBL27283684 N#Cc1c[nH]c2c(NS(=O)(=O)c3ccc(-c4nnc(O)o4)cc3)cccc12 Degrader C17H11N5O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-3KSJRX WO2024129634-A1_106 . Cc1ccc(NS(=O)(=O)c2ccc(-c3nnc(O)o3)cc2)c2[nH]cc(C#N)c12 Degrader C18H13N5O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-TNRPK3 WO2024129634-A1_107 . Cc1ccc(NS(=O)(=O)c2ccc(-c3noc(O)n3)cc2)c2[nH]cc(C#N)c12 Degrader C18H13N5O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-VKAVOR WO2024129634-A1_108 . CC(C)(O)C1CN(c2ccc(S(=O)(=O)Nc3cccc4c(C#N)c[nH]c34)cc2)C1 Degrader C21H22N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-H6FRQ2 WO2024129634-A1_109 . Cc1ccc(NS(=O)(=O)c2cc(C(C)(C)O)cc(C(F)(F)F)n2)c2[nH]cc(C#N)c12 Degrader C19H17F3N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-C4QK4C WO2024129634-A1_11 . CC1=C2C(C#N)=CNC2C(NS(=O)(=O)c2ccc(-c3ccnn3C)cc2)C=C1 Degrader C20H19N5O2S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-YLA7TO WO2024129634-A1_110 . Cc1ccc(NS(=O)(=O)c2cccc(CC(=O)N3CCCN(C)CC3)c2)c2[nH]cc(C#N)c12 Degrader C24H27N5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-TJ13E1 2-{3-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]phenyl}acetic acid SCHEMBL27283794; EN300-37109908; 2-{3-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]phenyl}acetic acid; 2732244-99-2 Cc1ccc(NS(=O)(=O)c2cccc(CC(=O)O)c2)c2[nH]cc(C#N)c12 Degrader C18H15N3O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-MK62LE WO2024129634-A1_112 N-(3-cyano-4-methyl-1H-indol-7-yl)-3-(2-oxo-2-piperazin-1-ylethyl)benzenesulfonamide Cc1ccc(NS(=O)(=O)c2cccc(CC(=O)N3CCNCC3)c2)c2[nH]cc(C#N)c12 Degrader C22H23N5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-QA3K6B WO2024129634-A1_113 . CC1(O)CN(c2ccc(S(=O)(=O)Nc3cccc4c(C#N)c[nH]c34)cn2)C1 Degrader C18H17N5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-K80N72 WO2024129634-A1_114 . CN1CCCN(C(=O)Cc2cccc(S(=O)(=O)Nc3cccc4c(C#N)c[nH]c34)c2)CC1 Degrader C23H25N5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-D0AAUW 2-[3-[(3-cyano-1H-indol-7-yl)sulfamoyl]phenyl]acetic acid SCHEMBL27283885 N#Cc1c[nH]c2c(NS(=O)(=O)c3cccc(CC(=O)O)c3)cccc12 Degrader C17H13N3O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-51HK7V WO2024129634-A1_116 . N#Cc1c[nH]c2c(NS(=O)(=O)c3cccc(CC(=O)N4CCNCC4)c3)cccc12 Degrader C21H21N5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-QXP2XQ WO2024129634-A1_117 . N#Cc1c[nH]c2c(NS(=O)(=O)c3ccc(OCC4(O)CCC4)cc3)cccc12 Degrader C20H19N3O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-U0CZKN WO2024129634-A1_118 . COc1cc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)cc(N(C)C)n1 Degrader C17H17N5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-U1FDNE WO2024129634-A1_119 . COc1cc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)cc(Cl)n1 Degrader C15H11ClN4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-N19KBB WO2024129634-A1_12 . Cc1ccc(P(C)(C)=O)cc1S(=O)(=O)Nc1ccc(C)c2c(C#N)c[nH]c12 Degrader C19H20N3O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-8HO7CJ SCHEMBL27283894 N-(3-cyano-1H-indol-7-yl)-4-[(3-hydroxyoxetan-3-yl)methoxy]benzenesulfonamide\; SCHEMBL27283894 N#Cc1c[nH]c2c(NS(=O)(=O)c3ccc(OCC4(O)COC4)cc3)cccc12 Degrader C19H17N3O5S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-JREGT9 WO2024129634-A1_121 . O=S(=O)(Nc1cccc2c(Cl)c[nH]c12)c1ccc(OCC2(O)CCC2)cc1 Degrader C19H19ClN2O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-T82LRT SCHEMBL27283995 N-(3-cyano-1H-indol-7-yl)-3-[(3-hydroxyoxetan-3-yl)methoxy]benzenesulfonamide\; SCHEMBL27283995 N#Cc1c[nH]c2c(NS(=O)(=O)c3cccc(OCC4(O)COC4)c3)cccc12 Degrader C19H17N3O5S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-N1MYLW SCHEMBL27283996 N-(3-cyano-4-methyl-1H-indol-7-yl)-2-(2-hydroxy-2-methylpropoxy)pyridine-4-sulfonamide\; SCHEMBL27283996 Cc1ccc(NS(=O)(=O)c2ccnc(OCC(C)(C)O)c2)c2[nH]cc(C#N)c12 Degrader C19H20N4O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-TB67KA SCHEMBL27283998 N-(3-cyano-1H-indol-7-yl)-2-(2-hydroxy-2-methylpropoxy)pyridine-4-sulfonamide\; SCHEMBL27283998 CC(C)(O)COc1cc(S(=O)(=O)Nc2cccc3c(C#N)c[nH]c23)ccn1 Degrader C18H18N4O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-D5WQNL SCHEMBL27284001 N-(3-cyano-1H-indol-7-yl)-3-(3-hydroxy-3-methylazetidin-1-yl)benzenesulfonamide\; SCHEMBL27284001 CC1(O)CN(c2cccc(S(=O)(=O)Nc3cccc4c(C#N)c[nH]c34)c2)C1 Degrader C19H18N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-E6IU5Q SCHEMBL27284003 N-(4-chloro-3-cyano-1H-indol-7-yl)-3-(3-hydroxy-3-methylazetidin-1-yl)benzenesulfonamide\; SCHEMBL27284003 CC1(O)CN(c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(C#N)c[nH]c34)c2)C1 Degrader C19H17ClN4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-CEJWX5 SCHEMBL27284091 N-(4-chloro-3-cyano-1H-indazol-7-yl)-3-(3-hydroxy-3-methylazetidin-1-yl)benzenesulfonamide\; SCHEMBL27284091 CC1(O)CN(c2cccc(S(=O)(=O)Nc3ccc(Cl)c4c(C#N)n[nH]c34)c2)C1 Degrader C18H16ClN5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-JG02Y6 WO2024129634-A1_128 . Cc1ccc(NS(=O)(=O)c2cccc(N(C)CCCc3ccc(O)cc3)c2)c2[nH]cc(C#N)c12 Degrader C26H26N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-U96FNN WO2024129634-A1_129 . Cc1ccc(NS(=O)(=O)c2cccc(NCCCc3ccc(O)cc3)c2)c2[nH]cc(C#N)c12 Degrader C25H24N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-4ZB5TE WO2024129634-A1_13 . Cc1ccc(NS(=O)(=O)c2cc(F)cc(P(C)(C)=O)c2)c2[nH]cc(C#N)c12 Degrader C18H17FN3O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-02MGVS SCHEMBL27284097 N-(3-cyano-1H-indol-7-yl)-3-[2-(2-fluoroethylamino)ethoxy]benzenesulfonamide\; SCHEMBL27284097 N#Cc1c[nH]c2c(NS(=O)(=O)c3cccc(OCCNCCF)c3)cccc12 Degrader C19H19FN4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-K2PHFE WO2024129634-A1_131 . N#Cc1n[nH]c2c(NS(=O)(=O)c3cccc(OCCNCCF)c3)cccc12 Degrader C18H18FN5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-GFMT85 WO2024129634-A1_132 N-(3-cyano-4-methyl-1H-indol-7-yl)-4-ethylsulfanyl-3-(methylamino)benzenesulfonamide CCSc1ccc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cc1NC Degrader C19H20N4O2S2 RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-JQYFKL SCHEMBL27284156 N-[5-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-2-ethylsulfanylphenyl]-3-(3-fluorophenyl)propanamide\; SCHEMBL27284156 CCSc1ccc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cc1NC(=O)CCc1cccc(F)c1 Degrader C27H25FN4O3S2 RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-3QTOXQ WO2024129634-A1_14 . Cc1ccc(NS(=O)(=O)c2cc(Cl)cc(P(C)(C)=O)c2)c2[nH]cc(C#N)c12 Degrader C18H17ClN3O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-H9Z6GX WO2024129634-A1_15 . Cc1ccc(NS(=O)(=O)c2cc(C(F)(F)F)cc(P(C)(C)=O)c2)c2[nH]cc(C#N)c12 Degrader C19H17F3N3O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-71ARMY WO2024129634-A1_16 . Cc1cc(P(C)(C)=O)cc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)c1 Degrader C19H20N3O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-AG0P83 WO2024129634-A1_17 . COc1ccc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cc1P(C)(C)=O Degrader C19H20N3O4PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-IZ0KLN WO2024129634-A1_18 . Cc1c(P(C)(C)=O)cccc1S(=O)(=O)Nc1ccc(C)c2c(C#N)c[nH]c12 Degrader C19H20N3O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-V0U72U WO2024129634-A1_19 . CCNC(=O)c1cc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)ccc1OC Degrader C20H20N4O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-24XGS0 SCHEMBL27284304 N-(3-cyano-4-methyl-1H-indol-7-yl)-3-(2-methoxyethoxy)benzenesulfonamide\; SCHEMBL27284304 COCCOc1cccc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)c1 Degrader C19H19N3O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-4Q6XVB SCHEMBL27284668 N-(3-cyano-4-methyl-1H-indol-7-yl)-3-(morpholine-4-carbonyl)benzenesulfonamide\; SCHEMBL27284668 Cc1ccc(NS(=O)(=O)c2cccc(C(=O)N3CCOCC3)c2)c2[nH]cc(C#N)c12 Degrader C21H20N4O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-KPKUSH WO2024129634-A1_21 . Cc1ccc(NS(=O)(=O)c2cccc(C(=O)N3CCCC3)c2)c2[nH]cc(C#N)c12 Degrader C21H20N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-R8SRIE SCHEMBL27282133 N-(3-cyano-4-methyl-1H-indol-7-yl)-3-dimethylphosphoryl-4-(trifluoromethyl)benzenesulfonamide\; SCHEMBL27282133 Cc1ccc(NS(=O)(=O)c2ccc(C(F)(F)F)c(P(C)(C)=O)c2)c2[nH]cc(C#N)c12 Degrader C19H17F3N3O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-U39RPX N-(3-cyano-1H-indol-7-yl)-3-(1H-pyrazol-4-yl)benzenesulfonamide 0 N#Cc1c[nH]c2c(NS(=O)(=O)c3cccc(-c4cn[nH]c4)c3)cccc12 Degrader C18H13N5O2S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-K809IG WO2024129634-A1_24 . CCc1ccc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)cc1P(C)(C)=O Degrader C20H22N3O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-ZV6EBO SCHEMBL27282226 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-4-(1H-pyrazol-4-yl)benzenesulfonamide\; SCHEMBL27282226 Cc1ccc(NS(=O)(=O)c2ccc(-c3cn[nH]c3)c(C#N)c2)c2[nH]cc(C#N)c12 Degrader C20H14N6O2S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-86P7MY WO2024129634-A1_26 . Cc1ccc(NS(=O)(=O)c2ccc(-c3cn[nH]c3)c(Cl)c2)c2[nH]cc(C#N)c12 Degrader C19H14ClN5O2S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-21UFUM WO2024129634-A1_27 . Cc1ccc(NS(=O)(=O)c2ccc(-c3cn[nH]c3)c(P(C)(C)=O)c2)c2[nH]cc(C#N)c12 Degrader C21H20N5O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-YUAWP1 SCHEMBL27282232 4-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-3-dimethylphosphorylbenzenesulfonamide\; SCHEMBL27282232 Cc1ccc(NS(=O)(=O)c2ccc(C#N)c(P(C)(C)=O)c2)c2[nH]cc(C#N)c12 Degrader C19H17N4O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-ZBJ7BF WO2024129634-A1_29 . CC1=C2C(C#N)=CNC2C(NS(=O)(=O)c2ccc(N3CCOCC3)cc2)C=C1 Degrader C20H22N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-2QNUBB WO2024129634-A1_3 N-(3-cyano-4-methyl-1H-indol-7-yl)-3-dimethylphosphorylbenzenesulfonamide Cc1ccc(NS(=O)(=O)c2cccc(P(C)(C)=O)c2)c2[nH]cc(C#N)c12 Degrader C18H18N3O3PS RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-E1BZBT WO2024129634-A1_30 . N#Cc1c[nH]c2c(NS(=O)(=O)c3ccc(-c4cn[nH]c4)cc3)cccc12 Degrader C18H13N5O2S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-JXNL3K 3-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]benzamide SCHEMBL23518787 Cc1ccc(NS(=O)(=O)c2cccc(C(N)=O)c2)c2[nH]cc(C#N)c12 Degrader C17H14N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-7O9SX8 3-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-N-methylbenzamide SCHEMBL21218377; US11807606, Compound 5; BDBM633521 CNC(=O)c1cccc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)c1 Degrader C18H16N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-U5RWW4 WO2024129634-A1_33 . Cc1ccc(NS(=O)(=O)c2cccc(N3CCOCC3)c2)c2[nH]cc(C#N)c12 Degrader C20H20N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-MZTYGK WO2024129634-A1_34 . Cc1ccc(NS(=O)(=O)c2cccc(C(=O)N(C)C)c2)c2[nH]cc(C#N)c12 Degrader C19H18N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-O3JLJM WO2024129634-A1_35 . Cc1ccc(NS(=O)(=O)c2cccc(C(=O)NCCO)c2)c2[nH]cc(C#N)c12 Degrader C19H18N4O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-W9F0U0 SCHEMBL27282321 3-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]-N-(2-methoxyethyl)benzamide\; SCHEMBL27282321 COCCNC(=O)c1cccc(S(=O)(=O)Nc2ccc(C)c3c(C#N)c[nH]c23)c1 Degrader C20H20N4O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-3BSQVW WO2024129634-A1_37 . Cc1ccc(NS(=O)(=O)c2cccc(C(=O)N3CCCCC3)c2)c2[nH]cc(C#N)c12 Degrader C22H22N4O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-ZRHBFI WO2024129634-A1_38 . Cc1ccc(NS(=O)(=O)c2cccc(C(=O)N3CCN(C)CC3)c2)c2[nH]cc(C#N)c12 Degrader C22H23N5O3S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-728P4E N-(3-cyano-1H-indol-7-yl)-3-(morpholine-4-carbonyl)benzenesulfonamide SCHEMBL27282425 N#Cc1c[nH]c2c(NS(=O)(=O)c3cccc(C(=O)N4CCOCC4)c3)cccc12 Degrader C20H18N4O4S RBM39 Q14498 DCAF15 WO-2024129634-A1 TPD-ILEIGY WO2024140637-A1_GT-03245 3-[6-[(4-benzhydrylpiperazin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-JPRRVS WO2024140637-A1_GT-03386 3-[6-[[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H30F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-87SIZ6 WO2024140637-A1_GT-03466 3-[6-[(4-benzhydrylpiperazin-1-yl)methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(c5ccccc5)c5ccccc5)CC4)c3F)C2=O)C(=O)N1 Degrader C31H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-Q8PQSH WO2024140637-A1_GT-03467 3-[6-[(4-benzhydrylpiperazin-1-yl)methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccc5)c5ccccc5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C31H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-XQTWE5 WO2024140637-A1_GT-03564 3-[6-[[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)c3F)C2=O)C(=O)N1 Degrader C31H29F3N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-YBTUHA WO2024140637-A1_GT-03565 3-[6-[[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C31H29F3N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-9LO9SP WO2024140637-A1_GT-03566 3-[6-[[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H30Cl2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-BTL90G WO2024140637-A1_GT-03567 3-[6-[[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)c3F)C2=O)C(=O)N1 Degrader C31H29Cl2FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-FY06WM WO2024140637-A1_GT-03568 3-[6-[[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C31H29Cl2FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-NW7C79 WO2024140637-A1_GT-03569 3-[6-[(3-benzhydryl-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(c4ccccc4)c4ccccc4)C5)ccc3C2=O)C(=O)N1 Degrader C32H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-ARNFP2 WO2024140637-A1_GT-03570 3-[6-[[(1R,4R)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C[C@H]5C[C@@H]4CN5C(c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C32H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-623REM WO2024140637-A1_GT-03571 3-[6-[[(2R)-4-benzhydryl-2-methylpiperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione C[C@@H]1CN(C(c2ccccc2)c2ccccc2)CCN1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C32H34N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-94FW54 WO2024140637-A1_GT-03572 3-[6-[(3-benzhydryl-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4C5CC4CN(C(c4ccccc4)c4ccccc4)C5)c3F)C2=O)C(=O)N1 Degrader C32H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-PEGG4D WO2024140637-A1_GT-03573 3-[6-[[(1R,4R)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4C[C@H]5C[C@@H]4CN5C(c4ccccc4)c4ccccc4)c3F)C2=O)C(=O)N1 Degrader C32H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-EEJG83 WO2024140637-A1_GT-03574 . C=CC1=C(/C(F)=C/CN2CCN(C(c3ccccc3)c3ccccc3)C[C@H]2C)CN(C2CCC(=O)NC2=O)C1=O Degrader C32H35FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-1YFXYK WO2024140637-A1_GT-03575 3-[6-[(3-benzhydryl-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(c4ccccc4)c4ccccc4)C5)cc(F)c3C2=O)C(=O)N1 Degrader C32H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-A8HW1M WO2024140637-A1_GT-03576 3-[6-[[(1R,4R)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C[C@H]5C[C@@H]4CN5C(c4ccccc4)c4ccccc4)cc(F)c3C2=O)C(=O)N1 Degrader C32H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-FJWNWI WO2024140637-A1_GT-03577 3-[6-[[(2R)-4-benzhydryl-2-methylpiperazin-1-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione C[C@@H]1CN(C(c2ccccc2)c2ccccc2)CCN1Cc1cc(F)c2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C32H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-JXRJJB WO2024140637-A1_GT-03646 3-[7-[(4-benzhydrylpiperazin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCN(C(c5ccccc5)c5ccccc5)CC4)cccc3C2=O)C(=O)N1 Degrader C31H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-CNANTB WO2024140637-A1_GT-03647 3-[7-[[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)cccc3C2=O)C(=O)N1 Degrader C31H30F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-AC8VSR WO2024140637-A1_GT-03648 . Cc1ccc(C(c2ccc(Cl)cc2)N2CCN(Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)cc1 Degrader C32H33ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-UU6XAW WO2024140637-A1_GT-03698 3-[6-[[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C31H29F3N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-1I7RFO WO2024140637-A1_GT-03699 3-[6-[[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C31H29Cl2FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-OVAARG WO2024140637-A1_GT-03700 3-[6-[(4-benzhydrylpiperazin-1-yl)methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccc5)c5ccccc5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C31H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-LRWBTF WO2024140637-A1_GT-03701 3-[6-[[4-[bis(3-fluorophenyl)methyl]piperazin-1-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C31H29F3N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-SQ31JD WO2024140637-A1_GT-03702 3-[6-[[4-[bis(3-fluorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H30F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-LA942V WO2024140637-A1_GT-03703 3-[6-[[4-[bis(3-fluorophenyl)methyl]piperazin-1-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)c3F)C2=O)C(=O)N1 Degrader C31H29F3N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-V06NAB WO2024140637-A1_GT-03704 3-[6-[[4-[bis(3-fluorophenyl)methyl]piperazin-1-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C31H29F3N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-3AZYVR WO2024140637-A1_GT-03721 3-[6-[[(1S,4S)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C[C@@H]5C[C@H]4CN5C(c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C32H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-4DJ0JZ WO2024140637-A1_GT-03722 3-[6-[(8-benzhydryl-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CC5CCC(C4)N5C(c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C33H34N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-45CY5X WO2024140637-A1_GT-03723 3-[6-[(4-benzhydryl-2,6-dimethylpiperazin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1CN(C(c2ccccc2)c2ccccc2)CC(C)N1Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C33H36N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-JCA82J WO2024140637-A1_GT-03724 3-[6-[[(1S,4S)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4C[C@@H]5C[C@H]4CN5C(c4ccccc4)c4ccccc4)c3F)C2=O)C(=O)N1 Degrader C32H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-I6OD38 WO2024140637-A1_GT-03725 3-[6-[(8-benzhydryl-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CC5CCC(C4)N5C(c4ccccc4)c4ccccc4)c3F)C2=O)C(=O)N1 Degrader C33H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-5JWGG7 WO2024140637-A1_GT-03726 3-[6-[(4-benzhydryl-2,6-dimethylpiperazin-1-yl)methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1CN(C(c2ccccc2)c2ccccc2)CC(C)N1Cc1ccc2c(c1F)CN(C1CCC(=O)NC1=O)C2=O Degrader C33H35FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-WEBL01 WO2024140637-A1_GT-03832 3-[7-fluoro-3-oxo-6-[[4-[phenyl(pyridin-2-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(c5ccccc5)c5ccccn5)CC4)c3F)C2=O)C(=O)N1 Degrader C30H30FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-HAKPLW WO2024140637-A1_GT-03833 3-[5-fluoro-3-oxo-6-[[4-[phenyl(pyridin-2-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccc5)c5ccccn5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C30H30FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-XGCGZN WO2024140637-A1_GT-03835 3-[4-fluoro-3-oxo-6-[[4-[phenyl(pyridin-2-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccc5)c5ccccn5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C30H30FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-6ZU6ZR WO2024140637-A1_GT-03836 3-[3-oxo-7-[[4-[phenyl(pyridin-2-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCN(C(c5ccccc5)c5ccccn5)CC4)cccc3C2=O)C(=O)N1 Degrader C30H31N5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-NKFIVX WO2024140637-A1_GT-03837 3-[6-[(3-benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C5CCC4CN(C(c4ccccc4)c4ccccc4)C5)ccc3C2=O)C(=O)N1 Degrader C33H34N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-KCPT9R WO2024140637-A1_GT-03838 3-[6-[(3-benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4C5CCC4CN(C(c4ccccc4)c4ccccc4)C5)c3F)C2=O)C(=O)N1 Degrader C33H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-EYYSOE WO2024140637-A1_GT-03839 3-[6-[(3-benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C5CCC4CN(C(c4ccccc4)c4ccccc4)C5)c(F)cc3C2=O)C(=O)N1 Degrader C33H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-FHW662 WO2024140637-A1_GT-03840 3-[6-[(3-benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C5CCC4CN(C(c4ccccc4)c4ccccc4)C5)cc(F)c3C2=O)C(=O)N1 Degrader C33H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-XTA6ZY WO2024140637-A1_GT-03872 3-[6-[(4-benzhydryl-3,5-dimethylpiperazin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1CN(Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC(C)N1C(c1ccccc1)c1ccccc1 Degrader C33H36N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-2A394O WO2024140637-A1_GT-03873 3-[6-[(4-benzhydryl-2,6-dimethylpiperazin-1-yl)methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1CN(C(c2ccccc2)c2ccccc2)CC(C)N1Cc1cc2c(cc1F)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C33H35FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-5L77OR WO2024140637-A1_GT-03874 3-[6-[(4-benzhydryl-2,6-dimethylpiperazin-1-yl)methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1CN(C(c2ccccc2)c2ccccc2)CC(C)N1Cc1cc(F)c2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C33H35FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-WBQY00 WO2024140637-A1_GT-03875 3-[7-[[4-[bis(3-fluorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)cccc3C2=O)C(=O)N1 Degrader C31H30F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-RJYUJU WO2024140637-A1_GT-03933 3-[6-[(5-benzhydryl-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CC5CCC4CN5C(c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C33H34N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-SZ6WX6 WO2024140637-A1_GT-03944 3-[6-[(4-benzhydryl-1,4-diazepan-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C32H34N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-OZ6WWI WO2024140637-A1_GT-04163 3-[6-[(5-benzhydryl-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CC5CCC4CN5C(c4ccccc4)c4ccccc4)c3F)C2=O)C(=O)N1 Degrader C33H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-DVI2YE WO2024140637-A1_GT-04164 3-[6-[(4-benzhydryl-1,4-diazepan-1-yl)methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCCN(C(c5ccccc5)c5ccccc5)CC4)c3F)C2=O)C(=O)N1 Degrader C32H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-IVE6X7 WO2024140637-A1_GT-04165 3-[6-[(4-benzhydryl-3,3-dimethylpiperazin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CN(Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CCN1C(c1ccccc1)c1ccccc1 Degrader C33H36N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-D8G7R4 WO2024140637-A1_GT-04166 3-[6-[(4-benzhydryl-3,3-dimethylpiperazin-1-yl)methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CN(Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)CCN1C(c1ccccc1)c1ccccc1 Degrader C33H35FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-HCCVLO WO2024140637-A1_GT-04225 3-[3-oxo-6-[[4-(N-phenylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCC(N(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-XM3E8T WO2024140637-A1_GT-04226 3-[7-fluoro-3-oxo-6-[[4-(N-phenylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCC(N(c5ccccc5)c5ccccc5)CC4)c3F)C2=O)C(=O)N1 Degrader C31H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-TQ3G22 WO2024140637-A1_GT-04227 3-[5-fluoro-3-oxo-6-[[4-(N-phenylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCC(N(c5ccccc5)c5ccccc5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C31H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-R9SFS2 WO2024140637-A1_GT-04244 2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]benzo[de]isoquinoline-1,3-dione O=C1CCC(N2Cc3cc(CN4C(=O)c5cccc6cccc(c56)C4=O)ccc3C2=O)C(=O)N1 Degrader C26H19N3O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-C5OWS4 WO2024140637-A1_GT-04247 3-[7-fluoro-3-oxo-6-[[4-[phenyl(pyridin-4-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(c5ccccc5)c5ccncc5)CC4)c3F)C2=O)C(=O)N1 Degrader C30H30FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-W5NXDH WO2024140637-A1_GT-04248 3-[5-fluoro-3-oxo-6-[[4-[phenyl(pyridin-4-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccc5)c5ccncc5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C30H30FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-7AZ7D5 WO2024140637-A1_GT-04249 3-[3-oxo-6-[[4-[phenyl(pyridin-3-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccc5)c5cccnc5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H31N5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-MBF71D WO2024140637-A1_GT-04250 3-[7-fluoro-3-oxo-6-[[4-[phenyl(pyridin-3-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(c5ccccc5)c5cccnc5)CC4)c3F)C2=O)C(=O)N1 Degrader C30H30FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-56JXPN WO2024140637-A1_GT-04251 3-[5-fluoro-3-oxo-6-[[4-[phenyl(pyridin-3-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccc5)c5cccnc5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C30H30FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-XZ6JXB WO2024140637-A1_GT-04383 3-[6-[[4-(dipyridin-2-ylmethyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccn5)c5ccccn5)CC4)ccc3C2=O)C(=O)N1 Degrader C29H30N6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-P8RVLM WO2024140637-A1_GT-04384 3-[6-[[4-(dipyridin-2-ylmethyl)piperazin-1-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccn5)c5ccccn5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C29H29FN6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-MHW59Q WO2024140637-A1_GT-04385 3-[6-[[4-(dipyridin-3-ylmethyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5cccnc5)c5cccnc5)CC4)ccc3C2=O)C(=O)N1 Degrader C29H30N6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-0UGHR2 WO2024140637-A1_GT-04386 3-[6-[[4-(dipyridin-3-ylmethyl)piperazin-1-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5cccnc5)c5cccnc5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C29H29FN6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-FMDCN2 WO2024140637-A1_GT-04523 3-[3-oxo-6-[[4-[(R)-phenyl(pyridin-2-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN([C@H](c5ccccc5)c5ccccn5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H31N5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-AL545V WO2024140637-A1_GT-04524 3-[3-oxo-6-[[4-[(S)-phenyl(pyridin-2-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN([C@@H](c5ccccc5)c5ccccn5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H31N5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-VAEB94 WO2024140637-A1_GT-04525 3-[3-oxo-6-[[4-(N-pyridin-2-ylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCC(N(c5ccccc5)c5ccccn5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H31N5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-3G41W9 WO2024140637-A1_GT-04945 3-[3-oxo-7-[[4-[phenyl(pyridin-4-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCN(C(c5ccccc5)c5ccncc5)CC4)cccc3C2=O)C(=O)N1 Degrader C30H31N5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-E96RYC WO2024140637-A1_GT-04948 3-[3-oxo-7-[[4-(N-pyridin-2-ylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCC(N(c5ccccc5)c5ccccn5)CC4)cccc3C2=O)C(=O)N1 Degrader C30H31N5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-9R2GNK WO2024140637-A1_GT-04992 3-[3-oxo-7-[[4-(N-phenylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCC(N(c5ccccc5)c5ccccc5)CC4)cccc3C2=O)C(=O)N1 Degrader C31H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-S19E1B WO2024140637-A1_GT-05686 . CC(=O)NC(=O)C(C)N1Cc2ccc(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)cc2C1=O Degrader C31H34N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-NMP10V WO2024140637-A1_GT-05687 3-[4-[(4-benzhydrylpiperazin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cccc(CN4CCN(C(c5ccccc5)c5ccccc5)CC4)c3C2=O)C(=O)N1 Degrader C31H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-HUST0F WO2024140637-A1_GT-05688 3-[6-[3-(4-benzhydrylpiperazin-1-yl)propyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CCCN4CCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C33H36N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-DNGABY WO2024140637-A1_GT-05689 3-[6-(4-benzhydrylpiperazine-1-carbonyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-A7WWH6 WO2024140637-A1_GT-05690 5-[(4-Benzhydrylpiperazin-1-yl)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCN(C(c5ccccc5)c5ccccc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-B7YZYL WO2024140637-A1_GT-05691 . O=C1CCC(N2C(=O)C3C=CC(C(=O)N4CCN(C(c5ccccc5)c5ccccc5)CC4)=CC3C2=O)C(=O)N1 Degrader C31H30N4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-Q1SB0S WO2024140637-A1_GT-05696 3-[6-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CCN4CCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C32H34N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-KP5TNR WO2024140637-A1_GT-05713 3-[6-[[4-(dipyridin-2-ylmethyl)piperazin-1-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(c5ccccn5)c5ccccn5)CC4)c3F)C2=O)C(=O)N1 Degrader C29H29FN6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-RLR08X WO2024140637-A1_GT-05714 3-[6-[[4-(dipyridin-2-ylmethyl)piperazin-1-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5ccccn5)c5ccccn5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C29H29FN6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-X69R2J WO2024140637-A1_GT-05715 3-[7-[[4-(dipyridin-2-ylmethyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCN(C(c5ccccn5)c5ccccn5)CC4)cccc3C2=O)C(=O)N1 Degrader C29H30N6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-WQKTZL WO2024140637-A1_GT-05716 3-[6-[[4-(dipyridin-3-ylmethyl)piperazin-1-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCN(C(c5cccnc5)c5cccnc5)CC4)c3F)C2=O)C(=O)N1 Degrader C29H29FN6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-ZDP9S3 WO2024140637-A1_GT-05717 3-[6-[[4-(dipyridin-3-ylmethyl)piperazin-1-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCN(C(c5cccnc5)c5cccnc5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C29H29FN6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-1AGPFZ WO2024140637-A1_GT-05718 3-[7-[[4-(dipyridin-3-ylmethyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CCN(C(c5cccnc5)c5cccnc5)CC4)cccc3C2=O)C(=O)N1 Degrader C29H30N6O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-ZTVUXW WO2024140637-A1_GT-05719 3-[5-[[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3ccc(CN4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H30F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-NEAH5U WO2024140637-A1_GT-05720 3-[4-[[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cccc(CN4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)c3C2=O)C(=O)N1 Degrader C31H30F2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-8JE4JF WO2024140637-A1_GT-05721 3-[7-(4-benzhydrylpiperazine-1-carbonyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(C(=O)N4CCN(C(c5ccccc5)c5ccccc5)CC4)cccc3C2=O)C(=O)N1 Degrader C31H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-R2CD7K WO2024140637-A1_GT-05722 4-[(4-Benzhydrylpiperazin-1-yl)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3cccc(CN4CCN(C(c5ccccc5)c5ccccc5)CC4)c3C2=O)C(=O)N1 Degrader C31H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-J6MKRJ WO2024140637-A1_GT-05723 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-[phenyl(pyridin-2-yl)methyl]piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCN(C(c5ccccc5)c5ccccn5)CC4)cc3C2=O)C(=O)N1 Degrader C30H29N5O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-FXTD78 WO2024140637-A1_GT-05724 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-(dipyridin-2-ylmethyl)piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCN(C(c5ccccn5)c5ccccn5)CC4)cc3C2=O)C(=O)N1 Degrader C29H28N6O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-3C6WH0 WO2024140637-A1_GT-05725 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-(dipyridin-3-ylmethyl)piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCN(C(c5cccnc5)c5cccnc5)CC4)cc3C2=O)C(=O)N1 Degrader C29H28N6O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-2FHWIC WO2024140637-A1_GT-05726 5-[[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H28F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-W00BA3 WO2024140637-A1_GT-05727 5-[[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H28Cl2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-ZS61V2 WO2024140637-A1_GT-05728 5-[(3-Benzhydryl-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4C5CC4CN(C(c4ccccc4)c4ccccc4)C5)cc3C2=O)C(=O)N1 Degrader C32H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-WB2UMU WO2024140637-A1_GT-05729 5-[[(1S,4S)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4C[C@@H]5C[C@H]4CN5C(c4ccccc4)c4ccccc4)cc3C2=O)C(=O)N1 Degrader C32H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-LENFP2 WO2024140637-A1_GT-05730 5-[(5-Benzhydryl-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CC5CCC4CN5C(c4ccccc4)c4ccccc4)cc3C2=O)C(=O)N1 Degrader C33H32N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-I75OF3 WO2024140637-A1_GT-05735 3-[5-[[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3ccc(CN4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H30Cl2N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-SDX9ZM WO2024140637-A1_GT-05736 . Cc1ccc(C(c2ccc(Cl)cc2)N2CCN(Cc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4)CC2)cc1 Degrader C32H33ClN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-PQXI8B WO2024140637-A1_GT-05737 3-[6-[(3-benzhydryl-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(c4ccccc4)c4ccccc4)C5)c(F)cc3C2=O)C(=O)N1 Degrader C32H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-OSJFKH WO2024140637-A1_GT-05738 3-[6-[(4-benzhydryl-1,4-diazepan-1-yl)methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCCN(C(c5ccccc5)c5ccccc5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C32H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-GK9IZ0 WO2024140637-A1_GT-05739 5-[(4-Benzhydryl-1,4-diazepan-1-yl)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCCN(C(c5ccccc5)c5ccccc5)CC4)cc3C2=O)C(=O)N1 Degrader C32H32N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-E8S10H WO2024140637-A1_GT-05740 5-[(4-Benzhydryl-2,6-dimethylpiperazin-1-yl)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1CN(C(c2ccccc2)c2ccccc2)CC(C)N1Cc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C33H34N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-9URKUN WO2024140637-A1_GT-05741 2-(2,6-dioxopiperidin-3-yl)-5-[[4-(N-phenylanilino)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCC(N(c5ccccc5)c5ccccc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-DB34UL WO2024140637-A1_GT-05742 2-(2,6-dioxopiperidin-3-yl)-5-[[4-(N-pyridin-2-ylanilino)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CCC(N(c5ccccc5)c5ccccn5)CC4)cc3C2=O)C(=O)N1 Degrader C30H29N5O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-FX6XV8 WO2024140637-A1_GT-05743 3-[6-[(4-benzhydrylpiperazin-1-yl)amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(NN4CCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H31N5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-V3TJAW WO2024140637-A1_GT-05744 3-[6-[(1-benzhydrylpiperidin-4-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CC4CCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C32H33N3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-WMFGN6 WO2024140637-A1_GT-05745 3-[6-[(1-benzhydrylazetidin-3-ylidene)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C=C4CN(C(c5ccccc5)c5ccccc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H27N3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-6FAX9H WO2024140637-A1_GT-05850 3-[6-(4-benzhydrylpiperazine-1-carbonyl)-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(c5ccccc5)c5ccccc5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C31H29FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-92GL36 WO2024140637-A1_GT-05851 3-[5-(4-benzhydrylpiperazine-1-carbonyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3ccc(C(=O)N4CCN(C(c5ccccc5)c5ccccc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-WYWH6D WO2024140637-A1_GT-05852 3-[4-(4-benzhydrylpiperazine-1-carbonyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cccc(C(=O)N4CCN(C(c5ccccc5)c5ccccc5)CC4)c3C2=O)C(=O)N1 Degrader C31H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-M5KNNR WO2024140637-A1_GT-05853 4-(4-Benzhydrylpiperazine-1-carbonyl)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3cccc(C(=O)N4CCN(C(c5ccccc5)c5ccccc5)CC4)c3C2=O)C(=O)N1 Degrader C31H28N4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-A33UCQ WO2024140637-A1_GT-05854 3-[3-oxo-6-[4-[phenyl(pyridin-2-yl)methyl]piperazine-1-carbonyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(c5ccccc5)c5ccccn5)CC4)ccc3C2=O)C(=O)N1 Degrader C30H29N5O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-W5XSDD WO2024140637-A1_GT-05855 . O=C1CCC(N2C(=O)c3ccc(C(=O)N4CCN(C(c5cccnc5)C5C=NC=CC5)CC4)cc3C2=O)C(=O)N1 Degrader C29H28N6O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-2X8LYV WO2024140637-A1_GT-05856 3-[7-fluoro-3-oxo-6-[[4-(N-pyridin-2-ylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CCC(N(c5ccccc5)c5ccccn5)CC4)c3F)C2=O)C(=O)N1 Degrader C30H30FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-C05YWS WO2024140637-A1_GT-05857 3-[5-fluoro-3-oxo-6-[[4-(N-pyridin-2-ylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CCC(N(c5ccccc5)c5ccccn5)CC4)c(F)cc3C2=O)C(=O)N1 Degrader C30H30FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-9GTFDM WO2024140637-A1_GT-05858 . O=C1C=CC(N2Cc3cc(CN4CCC(N(c5ccccc5)c5ccccn5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C30H28FN5O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-RWKBRW WO2024140637-A1_GT-05859 3-[6-[(1-benzhydrylazetidin-3-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CC4CN(C(c5ccccc5)c5ccccc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H29N3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-JZTR1Q WO2024140637-A1_GT-05864 3-[6-[(1-benzhydrylpiperidin-4-yl)amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(NC4CCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-ZGF1PH WO2024140637-A1_GT-05865 3-[6-(8-benzhydryl-3,8-diazabicyclo[3.2.1]octan-3-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(N4CC5CCC(C4)N5C(c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C32H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-WYYO0T WO2024140637-A1_GT-05866 3-[6-(3-benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(N4C5CCC4CN(C(c4ccccc4)c4ccccc4)C5)ccc3C2=O)C(=O)N1 Degrader C32H32N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-36CUFO WO2024140637-A1_GT-05867 3-[6-[4-[(4-benzhydrylpiperazin-1-yl)methyl]phenyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(-c4ccc(CN5CCN(C(c6ccccc6)c6ccccc6)CC5)cc4)ccc3C2=O)C(=O)N1 Degrader C37H36N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-DM6ODD WO2024140637-A1_GT-05868 3-[6-(1-benzhydrylpiperidin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C4CCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31N3O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-LP4XRO WO2024140637-A1_GT-05877 3-[4-fluoro-3-oxo-6-[4-[phenyl(pyridin-2-yl)methyl]piperazine-1-carbonyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(c5ccccc5)c5ccccn5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C30H28FN5O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-X6DB4G WO2024140637-A1_GT-05878 2-(2,6-Dioxopiperidin-3-yl)-5-[4-[phenyl(pyridin-2-yl)methyl]piperazine-1-carbonyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(C(=O)N4CCN(C(c5ccccc5)c5ccccn5)CC4)cc3C2=O)C(=O)N1 Degrader C30H27N5O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-M2UBBT WO2024140637-A1_GT-05880 2-(2,6-Dioxopiperidin-3-yl)-5-[4-(dipyridin-2-ylmethyl)piperazine-1-carbonyl]isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(C(=O)N4CCN(C(c5ccccn5)c5ccccn5)CC4)cc3C2=O)C(=O)N1 Degrader C29H26N6O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-M3IER9 WO2024140637-A1_GT-05881 3-[6-[4-[bis(4-fluorophenyl)methyl]piperazine-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H28F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-AMVTY7 WO2024140637-A1_GT-05882 3-[6-[4-[bis(4-fluorophenyl)methyl]piperazine-1-carbonyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C31H27F3N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-XAR52Y WO2024140637-A1_GT-05883 3-[5-[4-[bis(4-fluorophenyl)methyl]piperazine-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3ccc(C(=O)N4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H28F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-8PTDK7 WO2024140637-A1_GT-05884 3-[4-[4-[bis(4-fluorophenyl)methyl]piperazine-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cccc(C(=O)N4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)c3C2=O)C(=O)N1 Degrader C31H28F2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-FBMWBB WO2024140637-A1_GT-05885 5-[4-[Bis(4-fluorophenyl)methyl]piperazine-1-carbonyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(C(=O)N4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H26F2N4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-OAK1H8 WO2024140637-A1_GT-05886 3-[6-[4-[bis(4-chlorophenyl)methyl]piperazine-1-carbonyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H28Cl2N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-ANGEGM WO2024140637-A1_GT-05887 3-[6-[4-[bis(4-chlorophenyl)methyl]piperazine-1-carbonyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)cc(F)c3C2=O)C(=O)N1 Degrader C31H27Cl2FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-J1QYIU WO2024140637-A1_GT-05888 . Cc1ccc(C(c2ccc(Cl)cc2)N2CCN(C(=O)c3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)cc1 Degrader C32H31ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-AAX5QF WO2024140637-A1_GT-05889 . Cc1ccc(C(c2ccc(Cl)cc2)N2CCN(C(=O)c3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4)CC2)cc1 Degrader C32H31ClN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-2I8FA7 WO2024140637-A1_GT-05890 5-[4-[Bis(4-chlorophenyl)methyl]piperazine-1-carbonyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(C(=O)N4CCN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)CC4)cc3C2=O)C(=O)N1 Degrader C31H26Cl2N4O5 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-S4WV09 WO2024140637-A1_GT-05891 3-[6-(3-benzhydryl-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4C5CC4CN(C(c4ccccc4)c4ccccc4)C5)ccc3C2=O)C(=O)N1 Degrader C32H30N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-8DX3BZ WO2024140637-A1_GT-05892 3-[6-(4-benzhydryl-1,4-diazepane-1-carbonyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4CCCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C32H32N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-E53O7E WO2024140637-A1_GT-05894 3-[6-[[(1S,4S)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C[C@@H]5C[C@H]4CN5C(c4ccccc4)c4ccccc4)c(F)cc3C2=O)C(=O)N1 Degrader C32H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-3LID90 WO2024140637-A1_GT-05895 3-[6-[[(1S,4S)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4C[C@@H]5C[C@H]4CN5C(c4ccccc4)c4ccccc4)cc(F)c3C2=O)C(=O)N1 Degrader C32H31FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-ASG29N WO2024140637-A1_GT-05896 3-[6-[(8-benzhydryl-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CC5CCC(C4)N5C(c4ccccc4)c4ccccc4)c(F)cc3C2=O)C(=O)N1 Degrader C33H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-HLTD4E WO2024140637-A1_GT-05897 3-[6-[(8-benzhydryl-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CC5CCC(C4)N5C(c4ccccc4)c4ccccc4)cc(F)c3C2=O)C(=O)N1 Degrader C33H33FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-MGM5MJ WO2024140637-A1_GT-05898 5-[(8-Benzhydryl-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CC5CCC(C4)N5C(c4ccccc4)c4ccccc4)cc3C2=O)C(=O)N1 Degrader C33H32N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-YYQMDX WO2024140637-A1_GT-05899 5-[(3-Benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4C5CCC4CN(C(c4ccccc4)c4ccccc4)C5)cc3C2=O)C(=O)N1 Degrader C33H32N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-YOYH4O WO2024140637-A1_GT-05901 3-[6-[(7-benzhydryl-2,7-diazaspiro[3.5]nonan-2-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CC5(CCN(C(c6ccccc6)c6ccccc6)CC5)C4)ccc3C2=O)C(=O)N1 Degrader C34H36N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-UMJ2VF WO2024140637-A1_GT-05902 3-[6-[(7-benzhydryl-2,7-diazaspiro[3.5]nonan-2-yl)methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(ccc(CN4CC5(CCN(C(c6ccccc6)c6ccccc6)CC5)C4)c3F)C2=O)C(=O)N1 Degrader C34H35FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-XWSXKW WO2024140637-A1_GT-05903 3-[6-[(7-benzhydryl-2,7-diazaspiro[3.5]nonan-2-yl)methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CC5(CCN(C(c6ccccc6)c6ccccc6)CC5)C4)c(F)cc3C2=O)C(=O)N1 Degrader C34H35FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-4E13MV WO2024140637-A1_GT-05904 3-[6-[(7-benzhydryl-2,7-diazaspiro[3.5]nonan-2-yl)methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(CN4CC5(CCN(C(c6ccccc6)c6ccccc6)CC5)C4)cc(F)c3C2=O)C(=O)N1 Degrader C34H35FN4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-LRTCB7 WO2024140637-A1_GT-05905 3-[7-[(7-benzhydryl-2,7-diazaspiro[3.5]nonan-2-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(CN4CC5(CCN(C(c6ccccc6)c6ccccc6)CC5)C4)cccc3C2=O)C(=O)N1 Degrader C34H36N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-CKCITE WO2024140637-A1_GT-05906 5-[(7-Benzhydryl-2,7-diazaspiro[3.5]nonan-2-yl)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)c3ccc(CN4CC5(CCN(C(c6ccccc6)c6ccccc6)CC5)C4)cc3C2=O)C(=O)N1 Degrader C34H34N4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-NLCFXT WO2024140637-A1_GT-05907 . CCCC(C(=O)NC=O)N1Cc2cc(CN3CCN(C4c5ccccc5-c5ccccc54)CC3)ccc2C1=O Degrader C32H34N4O3 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-BSVINU WO2024140637-A1_GT-05908 . O=C1CCC(N2C(=O)c3ccc(CN4CC[Ni](C5c6ccccc6-c6ccccc65)CC4)cc3C2=O)C(=O)N1 Degrader C31H28N3NiO4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-5LSZL8 WO2024140637-A1_GT-05916 3-[6-(3-benzhydryl-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(C(=O)N4C5CC4CN(C(c4ccccc4)c4ccccc4)C5)cc(F)c3C2=O)C(=O)N1 Degrader C32H29FN4O4 IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024140637-A1 TPD-JL6O4E WO2024140638-A1_GT-03357 . Cc1ccc(-c2ccccc2CN2CCC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)cc1 Degrader C32H33N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-WQF3VL WO2024140638-A1_GT-03360 3-[6-[1-[[2-(4-chlorophenyl)phenyl]methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H26ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-NCF9FH WO2024140638-A1_GT-03363 . O=C1CCC(N2Cc3cc(OC4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H26ClN3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-XJ2DDP WO2024140638-A1_GT-03369 3-[6-[1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC(Oc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 Degrader C31H34ClN3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-27CA8D WO2024140638-A1_GT-03457 . CC1(C)CCC(CN2CC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 Degrader C31H34FN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-QPBPBF WO2024140638-A1_GT-03459 . CC1(C)CCC(CN2CC(Oc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 Degrader C31H34FN3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-DH3VI6 WO2024140638-A1_GT-03462 3-[6-[1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperidin-4-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H38ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-QYHNBK WO2024140638-A1_GT-03464 3-[6-[1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 Degrader C31H34ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-EJA9ZX WO2024140638-A1_GT-03892 . Cc1ccc(-c2ccccc2C(=O)N2CC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)cc1 Degrader C30H27N3O4S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-TOA0VT WO2024140638-A1_GT-04195 . O=C1CCC(N2Cc3cc(SC4CCN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H28ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-SDES9J WO2024140638-A1_GT-04245 3-[6-[1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]pyrrolidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 Degrader C32H36ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-2FTAJI WO2024140638-A1_GT-06137 . Cc1ccc(C2=C(C(=O)N3CC(Sc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)CCC(C)(C)C2)cc1 Degrader C32H35N3O4S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-WLMWFV WO2024140638-A1_GT-06138 3-[6-(1-benzhydrylazetidin-3-yl)sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CN(C(c5ccccc5)c5ccccc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H27N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-2ZR7RD WO2024140638-A1_GT-06139 3-[6-[1-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]pyrrolidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CCC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 Degrader C32H34ClN3O4S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-R6034W WO2024140638-A1_GT-06180 . Cc1ccc(C2=C(C(=O)N3CC(Oc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)CCC(C)(C)C2)cc1 Degrader C32H35N3O5 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-8CA7Y1 WO2024140638-A1_GT-06181 . Cc1ccc(-c2ccccc2C(=O)N2CCC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)cc1 Degrader C31H29N3O4S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-QTZM5W WO2024140638-A1_GT-06182 3-[6-[1-[2-(4-chlorophenyl)benzoyl]piperidin-4-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H28ClN3O4S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-H8FJDT WO2024140638-A1_GT-06183 3-[6-[1-[2-(4-chlorophenyl)benzoyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(C(=O)c5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H24ClN3O5 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-WBQ0HG WO2024140638-A1_GT-06184 . O=C1CCC(N2Cc3cc(SC4CCN(C(c5ccccc5)C5C=CC=CC5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H33N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-YJVCSV WO2024140638-A1_GT-06185 3-[6-(1-benzhydrylazetidin-3-yl)oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(C(c5ccccc5)c5ccccc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H27N3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-5L3GUM WO2024140638-A1_GT-06192 3-[6-[1-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]piperidin-4-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CCC(Oc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H36ClN3O5 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-PIG35E WO2024140638-A1_GT-06193 3-[6-[1-[[2-(4-chlorophenyl)phenyl]methyl]piperidin-4-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H30ClN3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-710I3M WO2024140638-A1_GT-06195 3-[6-(1-benzhydrylpiperidin-4-yl)oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H31N3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-9OVXFK WO2024140638-A1_GT-06196 3-[6-(1-benzhydrylpyrrolidin-3-yl)sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CCN(C(c5ccccc5)c5ccccc5)C4)ccc3C2=O)C(=O)N1 Degrader C30H29N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-K8RD9D WO2024140638-A1_GT-06204 3-[6-[1-[2-(4-chlorophenyl)benzoyl]piperidin-4-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C31H28ClN3O5 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-5293NU WO2024140638-A1_GT-06225 . O=C1CCC(N2Cc3cc(SC4CN(CC5C=C(c6ccc(Cl)cc6)C=CC5)C4)ccc3C2=O)C(=O)N1 Degrader C29H28ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-1KP6WV WO2024140638-A1_GT-06226 3-[6-[1-[[4-(4-chlorophenyl)phenyl]methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CN(Cc5ccc(-c6ccc(Cl)cc6)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H26ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-5QXFL1 WO2024140638-A1_GT-06227 3-[6-[1-[[3-(4-chlorophenyl)phenyl]methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(Cc5cccc(-c6ccc(Cl)cc6)c5)C4)ccc3C2=O)C(=O)N1 Degrader C29H26ClN3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-HYBYKG WO2024140638-A1_GT-06228 . O=C1CCC(N2Cc3cc(OC4CCN(CC5C=C(c6ccc(Cl)cc6)C=CC5)CC4)ccc3C2=S)C(=O)N1 Degrader C31H32ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-9F83AN WO2024140638-A1_GT-06230 3-[6-[1-[[4-(4-chlorophenyl)phenyl]methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(Cc5ccc(-c6ccc(Cl)cc6)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H26ClN3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-YL9ZLP WO2024140638-A1_GT-06302 . O=C1CCC(N2Cc3cc(OC4CN(CC5=C(C6C=CC(F)=CC6)CCCC5)C4)ccc3C2=O)C(=O)N1 Degrader C29H32FN3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-YGZBF8 WO2024140638-A1_GT-06349 3-[6-[1-[bis(3-fluorophenyl)methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CN(C(c5cccc(F)c5)c5cccc(F)c5)C4)ccc3C2=O)C(=O)N1 Degrader C29H25F2N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-71LPAW WO2024140638-A1_GT-06352 3-[6-[1-[bis(3-fluorophenyl)methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(C(c5cccc(F)c5)c5cccc(F)c5)C4)ccc3C2=O)C(=O)N1 Degrader C29H25F2N3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-AC1E7P WO2024140638-A1_GT-06354 3-[6-[1-[[4-(4-chlorophenyl)-3,6-dihydro-2H-pyran-5-yl]methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(CC5=C(c6ccc(Cl)cc6)CCOC5)C4)ccc3C2=O)C(=O)N1 Degrader C28H28ClN3O5 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-4RCP2F WO2024140638-A1_GT-06503 3-[6-[1-[bis(4-fluorophenyl)methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CN(C(c5ccc(F)cc5)c5ccc(F)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H25F2N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-DHQGJQ WO2024140638-A1_GT-06504 3-[6-[1-[bis(4-chlorophenyl)methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H25Cl2N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-VUXB42 WO2024140638-A1_GT-06514 3-[6-[1-[[4-(4-chlorophenyl)-6,6-dimethyl-2,5-dihydropyran-3-yl]methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CC(c2ccc(Cl)cc2)=C(CN2CC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)CO1 Degrader C30H32ClN3O4S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-TGIX0L WO2024140638-A1_GT-06515 . CC1(C)CCC(CN2CC(Sc3cccc4c3CN(C3CCCNC3=O)C4=O)C2)=C(c2ccc(O)cc2)C1 Degrader C31H37N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-84K6UA WO2024140638-A1_GT-06516 . Cc1ccc(C2=C(CN3CC(Sc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)CC(F)(F)CC2)cc1 Degrader C30H31F2N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-JRGYTD WO2024140638-A1_GT-06517 3-[6-[1-[[5-(furan-2-yl)thiophen-2-yl]methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CN(Cc5ccc(-c6ccco6)s5)C4)ccc3C2=O)C(=O)N1 Degrader C25H23N3O4S2 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-I51I3H WO2024140638-A1_GT-06518 3-[3-oxo-6-[1-[phenyl(pyridin-2-yl)methyl]azetidin-3-yl]sulfanyl-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CN(C(c5ccccc5)c5ccccn5)C4)ccc3C2=O)C(=O)N1 Degrader C28H26N4O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-PXYSU6 WO2024140638-A1_GT-06519 3-[6-[1-[bis(4-fluorophenyl)methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(C(c5ccc(F)cc5)c5ccc(F)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H25F2N3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-D5OCN2 WO2024140638-A1_GT-06520 3-[6-[1-[bis(4-chlorophenyl)methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 Degrader C29H25Cl2N3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-B3QG8H WO2024140638-A1_GT-06559 3-[3-oxo-6-[1-[phenyl(pyridin-2-yl)methyl]azetidin-3-yl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(C(c5ccccc5)c5ccccn5)C4)ccc3C2=O)C(=O)N1 Degrader C28H26N4O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-RJRAHL WO2024140638-A1_GT-06560 3-[6-[1-[[4-(4-fluorophenyl)-3,6-dihydro-2H-pyran-5-yl]methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(CC5=C(c6ccc(F)cc6)CCOC5)C4)ccc3C2=O)C(=O)N1 Degrader C28H28FN3O5 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-2U1002 WO2024140638-A1_GT-06561 3-[6-[1-[[4-(4-chlorophenyl)-6,6-dimethyl-2,5-dihydropyran-3-yl]methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CC(c2ccc(Cl)cc2)=C(CN2CC(Oc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)CO1 Degrader C30H32ClN3O5 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-MQGVQ4 WO2024140638-A1_GT-06562 3-[6-[1-[[5-(furan-2-yl)thiophen-2-yl]methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(Cc5ccc(-c6ccco6)s5)C4)ccc3C2=O)C(=O)N1 Degrader C25H23N3O5S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-C6A10H WO2024140638-A1_GT-06563 3-[6-[1-[[2-(4-chlorophenyl)-5,5-difluorocyclohexen-1-yl]methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(CC5=C(c6ccc(Cl)cc6)CCC(F)(F)C5)C4)ccc3C2=O)C(=O)N1 Degrader C29H28ClF2N3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-6TI0H9 WO2024140638-A1_GT-06641 3-[6-[1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]azepan-4-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CCCC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C34H40ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-904L6E WO2024140638-A1_GT-06642 3-[6-[1-[2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-carbonyl]piperidin-4-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(C(=O)N2CCC(Sc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 Degrader C33H36ClN3O4S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-M8EMZ6 WO2024140638-A1_GT-06643 . O=C1CCC(N2Cc3cc(SC4CCCN(Cc5ccccc5-c5ccc(CI)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C33H34IN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-JMJG8S WO2024140638-A1_GT-06644 3-[6-[1-[2-(4-chlorophenyl)benzoyl]azepan-4-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CCCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 Degrader C32H30ClN3O4S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-CVLT0A WO2024140638-A1_GT-06645 3-[6-(1-benzhydrylazepan-4-yl)sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CCCN(C(c5ccccc5)c5ccccc5)CC4)ccc3C2=O)C(=O)N1 Degrader C32H33N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-ZT4KGS WO2024140638-A1_GT-06757 3-[5-[1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1(C)CCC(CN2CC(Sc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)C2)=C(c2ccc(Cl)cc2)C1 Degrader C31H34ClN3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-2ZEIDR WO2024140638-A1_GT-06758 3-[6-[1-[bis(2-fluorophenyl)methyl]azetidin-3-yl]sulfanyl-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(SC4CN(C(c5ccccc5F)c5ccccc5F)C4)ccc3C2=O)C(=O)N1 Degrader C29H25F2N3O3S CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-ZIFT17 WO2024140638-A1_GT-06759 3-[6-[1-[bis(2-fluorophenyl)methyl]azetidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3cc(OC4CN(C(c5ccccc5F)c5ccccc5F)C4)ccc3C2=O)C(=O)N1 Degrader C29H25F2N3O4 CK1α;WEE1;IKZF1;IKZF2;IKZF3;GSPT1 P48729/P30291/Q13422/Q9UKS7/Q9UKT9/P15170 CRBN WO-2024140638-A1 TPD-DSHR21 8-Chloro-7-(4-methylphenyl)-1,3-dihydroimidazo[4,5-b]quinolin-2-one 0 Cc1ccc(-c2ccc3nc4[nH]c(=O)[nH]c4cc3c2Cl)cc1 Stabilizer C17H12ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-MYXYG9 WO2024149378-A1_10 7-(3-Chloro-5-fluoropyridin-2-yl)-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4ncc(F)cc4Cl)ccc3nc2[nH]1 Stabilizer C15H8ClFN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-4BNU24 WO2024149378-A1_11 7-[1-(Difluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cnn(C(F)F)c4)ccc3nc2[nH]1 Stabilizer C14H9F2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-OXT2AB WO2024149378-A1_12 7-[3-Chloro-1-(difluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cn(C(F)F)nc4Cl)ccc3nc2[nH]1 Stabilizer C14H8ClF2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-2EC1E7 WO2024149378-A1_13 7-[5-Chloro-1-(difluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cnn(C(F)F)c4Cl)ccc3nc2[nH]1 Stabilizer C14H8ClF2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-9W2K2P 3-Chloro-4-(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)benzonitrile 0 N#Cc1ccc(-c2ccc3nc4[nH]c(=O)[nH]c4cc3c2)c(Cl)c1 Stabilizer C17H9ClN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-Z68623 WO2024149378-A1_15 7-[4-Chloro-1-(difluoromethyl)pyrazol-3-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4nn(C(F)F)cc4Cl)ccc3nc2[nH]1 Stabilizer C14H8ClF2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-CRYR4I WO2024149378-A1_16 7-[4-Chloro-2-(difluoromethyl)pyrazol-3-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4c(Cl)cnn4C(F)F)ccc3nc2[nH]1 Stabilizer C14H8ClF2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-5BX1XC WO2024149378-A1_17 7-[2-Chloro-6-(trifluoromethyl)pyridin-3-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4ccc(C(F)(F)F)nc4Cl)ccc3nc2[nH]1 Stabilizer C16H8ClF3N4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-IN7SUV 7-(2,6-Dichloropyridin-3-yl)-1,3-dihydroimidazo[4,5-b]quinolin-2-one 0 O=c1[nH]c2cc3cc(-c4ccc(Cl)nc4Cl)ccc3nc2[nH]1 Stabilizer C15H8Cl2N4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-XIVA36 WO2024149378-A1_19 7-(6-Amino-2-chloropyridin-3-yl)-1,3-dihydroimidazo[4,5-b]quinolin-2-one Nc1ccc(-c2ccc3nc4[nH]c(=O)[nH]c4cc3c2)c(Cl)n1 Stabilizer C15H10ClN5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-R5B9ST 5-Chloro-6-(4-methylphenyl)-1,3-dihydropyrrolo[2,3-b]quinolin-2-one 0 Cc1ccc(-c2ccc3nc4c(cc3c2Cl)CC(=O)N4)cc1 Stabilizer C18H13ClN2O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-KMRP8Z 7-phenyl-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-2-one 0 O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1ccccc1)C3 Stabilizer C15H14N4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-NJ8567 WO2024149378-A1_21 7-(2-chloro-4-fluorophenyl)-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-2-one O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1ccc(F)cc1Cl)C3 Stabilizer C15H12ClFN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-OIZY75 WO2024149378-A1_22 3-chloro-4-(2-oxo-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-7-yl)benzonitrile N#Cc1ccc(N2CCc3nc4[nH]c(=O)[nH]c4cc3C2)c(Cl)c1 Stabilizer C16H12ClN5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-ZC3780 WO2024149378-A1_23 . O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1ncc(F)cc1Cl)C3 Stabilizer C14H11ClFN5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-6VN3JU WO2024149378-A1_24 8-Chloro-7-(5-fluoropyridin-2-yl)-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3c(Cl)c(-c4ccc(F)cn4)ccc3nc2[nH]1 Stabilizer C15H8ClFN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-U86JZK 7-(2-Chloro-4-methylphenyl)-1,3-dihydroimidazo[4,5-b]quinolin-2-one 0 Cc1ccc(-c2ccc3nc4[nH]c(=O)[nH]c4cc3c2)c(Cl)c1 Stabilizer C17H12ClN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-G8CF9L 7-(2-Aminopyridin-4-yl)-1,3-dihydroimidazo[4,5-b]quinolin-2-one 0 Nc1cc(-c2ccc3nc4[nH]c(=O)[nH]c4cc3c2)ccn1 Stabilizer C15H11N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-SC2KXY WO2024149378-A1_29 7-[1-(Trifluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cnn(C(F)(F)F)c4)ccc3nc2[nH]1 Stabilizer C14H8F3N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-7MAH7K 7-(2-Chloro-4-fluorophenyl)-1,3-dihydroimidazo[4,5-b]quinolin-2-one 0 O=c1[nH]c2cc3cc(-c4ccc(F)cc4Cl)ccc3nc2[nH]1 Stabilizer C16H9ClFN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-OZOBLG WO2024149378-A1_30 7-[1-(Difluoromethyl)-5-(trifluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cnn(C(F)F)c4C(F)(F)F)ccc3nc2[nH]1 Stabilizer C15H8F5N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-IGPHRD WO2024149378-A1_31 7-[1-(Difluoromethyl)-3-(trifluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cn(C(F)F)nc4C(F)(F)F)ccc3nc2[nH]1 Stabilizer C15H8F5N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-EDYLNQ WO2024149378-A1_32 7-[5-Bromo-1-(difluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cnn(C(F)F)c4Br)ccc3nc2[nH]1 Stabilizer C14H8BrF2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-4YYMS8 WO2024149378-A1_33 7-[3-Bromo-1-(difluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cn(C(F)F)nc4Br)ccc3nc2[nH]1 Stabilizer C14H8BrF2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-PON4QQ WO2024149378-A1_34 7-[4-Chloro-3-(difluoromethyl)-1,2-oxazol-5-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4onc(C(F)F)c4Cl)ccc3nc2[nH]1 Stabilizer C14H7ClF2N4O2 PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-6TBX0Z WO2024149378-A1_35 7-[2-Chloro-6-(difluoromethyl)pyridin-3-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4ccc(C(F)F)nc4Cl)ccc3nc2[nH]1 Stabilizer C16H9ClF2N4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-6TXZ42 WO2024149378-A1_36 7-[2-Chloro-4-(difluoromethyl)phenyl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4ccc(C(F)F)cc4Cl)ccc3nc2[nH]1 Stabilizer C17H10ClF2N3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-GD9CPK WO2024149378-A1_37 7-[5-Chloro-1-(difluoromethyl)imidazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4ncn(C(F)F)c4Cl)ccc3nc2[nH]1 Stabilizer C14H8ClF2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-8457DC WO2024149378-A1_38 7-[5-Chloro-3-(difluoromethyl)imidazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4c(Cl)ncn4C(F)F)ccc3nc2[nH]1 Stabilizer C14H8ClF2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-7T5AFD WO2024149378-A1_39 7-[6-Chloro-2-(difluoromethoxy)pyridin-3-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4ccc(Cl)nc4OC(F)F)ccc3nc2[nH]1 Stabilizer C16H9ClF2N4O2 PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-JR8Q5F 7-(4-Fluoro-2-methylphenyl)-1,3-dihydroimidazo[4,5-b]quinolin-2-one 0 Cc1cc(F)ccc1-c1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Stabilizer C17H12FN3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-05R1TZ WO2024149378-A1_40 7-[2-Chloro-6-(methylamino)pyridin-3-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one CNc1ccc(-c2ccc3nc4[nH]c(=O)[nH]c4cc3c2)c(Cl)n1 Stabilizer C16H12ClN5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-SPLQNM WO2024149378-A1_41 . Nc1nc(Cl)ccc1-c1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Stabilizer C15H10ClN5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-WZ0N76 WO2024149378-A1_42 7-[5-(Difluoromethoxy)-1-(difluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cnn(C(F)F)c4OC(F)F)ccc3nc2[nH]1 Stabilizer C15H9F4N5O2 PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-0N3W51 WO2024149378-A1_43 7-[3-(Difluoromethoxy)-1-(difluoromethyl)pyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one O=c1[nH]c2cc3cc(-c4cn(C(F)F)nc4OC(F)F)ccc3nc2[nH]1 Stabilizer C15H9F4N5O2 PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-7QUTKX WO2024149378-A1_44 7-[1-(Difluoromethyl)-5-methylpyrazol-4-yl]-1,3-dihydroimidazo[4,5-b]quinolin-2-one Cc1c(-c2ccc3nc4[nH]c(=O)[nH]c4cc3c2)cnn1C(F)F Stabilizer C15H11F2N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-U3WSW8 WO2024149378-A1_46 7-[2-chloro-4-(difluoromethyl)phenyl]-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-2-one O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1ccc(C(F)F)cc1Cl)C3 Stabilizer C16H13ClF2N4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-9WDXLM WO2024149378-A1_47 7-(2,4-dichlorophenyl)-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-2-one O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1ccc(Cl)cc1Cl)C3 Stabilizer C15H12Cl2N4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-LQO0ST WO2024149378-A1_48 . O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1ccc(C(F)(F)F)nc1Cl)C3 Stabilizer C15H11ClF3N5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-I39NFU WO2024149378-A1_49 7-(3-fluorophenyl)-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-2-one O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1cccc(F)c1)C3 Stabilizer C15H13FN4O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-C6LIWU WO2024149378-A1_5 . O=c1[nH]c2cc3cc(-c4ccc(F)cc4C(F)(F)F)ccc3nc2[nH]1 Stabilizer C17H9F4N3O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-4F4450 WO2024149378-A1_50 7-[5-chloro-1-(difluoromethyl)pyrazol-4-yl]-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-2-one O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1cnn(C(F)F)c1Cl)C3 Stabilizer C13H11ClF2N6O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-26Q52P WO2024149378-A1_51 7-[3-chloro-1-(difluoromethyl)pyrazol-4-yl]-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-2-one O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1cn(C(F)F)nc1Cl)C3 Stabilizer C13H11ClF2N6O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-SOENDL WO2024149378-A1_52 3-fluoro-4-(2-oxo-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-7-yl)benzonitrile N#Cc1ccc(N2CCc3nc4[nH]c(=O)[nH]c4cc3C2)c(F)c1 Stabilizer C16H12FN5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-ASUUAI WO2024149378-A1_53 2-fluoro-4-(2-oxo-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-7-yl)benzonitrile N#Cc1ccc(N2CCc3nc4[nH]c(=O)[nH]c4cc3C2)cc1F Stabilizer C16H12FN5O PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-EPHHGI WO2024149378-A1_54 7-[2-chloro-4-(trifluoromethoxy)phenyl]-3,5,6,8-tetrahydro-1H-imidazo[4,5-b][1,6]naphthyridin-2-one O=c1[nH]c2cc3c(nc2[nH]1)CCN(c1ccc(OC(F)(F)F)cc1Cl)C3 Stabilizer C16H12ClF3N4O2 PDE3A;SLFN12 Q14432/Q8IYM2 . WO-2024149378-A1 TPD-PJ1DNZ WO2024165577-A1_1 2-(4-tert-butylphenyl)-N-[[3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-6-yl]methyl]-2-oxoacetamide Cc1nc2ccc(CNC(=O)C(=O)c3ccc(C(C)(C)C)cc3)cc2cc1C1CCC(=O)NC1=O Degrader C28H29N3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-WPEEKA WO2024165577-A1_10 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(4-tert-butyl-3-chlorophenyl)carbamate Cc1nc2cc(COC(=O)Nc3ccc(C(C)(C)C)c(Cl)c3)ccc2cc1C1CCC(=O)NC1=O Degrader C27H28ClN3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-ZXG8B3 WO2024165577-A1_11 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(3-chloro-4-methoxyphenyl)carbamate COc1ccc(NC(=O)OCc2ccc3cc(C4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C24H22ClN3O5 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-WNW4SH WO2024165577-A1_12 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(3,4-dichlorophenyl)carbamate Cc1nc2cc(COC(=O)Nc3ccc(Cl)c(Cl)c3)ccc2cc1C1CCC(=O)NC1=O Degrader C23H19Cl2N3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-PXTK45 WO2024165577-A1_13 3-[7-[[[5-(3-Chloro-4-methylphenyl)-1,3,4-oxadiazol-2-yl]amino]methyl]-2-methylquinolin-3-yl]piperidine-2,6-dione Cc1ccc(-c2nnc(NCc3ccc4cc(C5CCC(=O)NC5=O)c(C)nc4c3)o2)cc1Cl Degrader C25H22ClN5O3 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-TDBQ9S WO2024165577-A1_14 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(1,3-benzodioxol-5-yl)carbamate Cc1nc2cc(COC(=O)Nc3ccc4c(c3)OCO4)ccc2cc1C1CCC(=O)NC1=O Degrader C24H21N3O6 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-QBXVTW WO2024165577-A1_15 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(2,3-dihydro-1,4-benzodioxin-6-yl)carbamate Cc1nc2cc(COC(=O)Nc3ccc4c(c3)OCCO4)ccc2cc1C1CCC(=O)NC1=O Degrader C25H23N3O6 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-YCWNPN WO2024165577-A1_17 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-[3-chloro-4-methyl-5-(morpholin-4-ylmethyl)phenyl]carbamate Cc1nc2cc(COC(=O)Nc3cc(Cl)c(C)c(CN4CCOCC4)c3)ccc2cc1C1CCC(=O)NC1=O Degrader C29H31ClN4O5 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-G0IE4C WO2024165577-A1_18 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-[3-chloro-4-(trifluoromethyl)phenyl]carbamate Cc1nc2cc(COC(=O)Nc3ccc(C(F)(F)F)c(Cl)c3)ccc2cc1C1CCC(=O)NC1=O Degrader C24H19ClF3N3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-D0GF1P WO2024165577-A1_19 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-[3-(trifluoromethoxy)phenyl]carbamate Cc1nc2cc(COC(=O)Nc3cccc(OC(F)(F)F)c3)ccc2cc1C1CCC(=O)NC1=O Degrader C24H20F3N3O5 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-OKASJJ WO2024165577-A1_2 1-(3-Chloro-4-methylphenyl)-3-[[3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl]thiourea Cc1ccc(NC(=S)NCc2ccc3cc(C4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C24H23ClN4O2S GSPT1 P15170 CRBN WO-2024165577-A1 TPD-EYJZRM WO2024165577-A1_20 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(6-phenylpyridin-3-yl)carbamate Cc1nc2cc(COC(=O)Nc3ccc(-c4ccccc4)nc3)ccc2cc1C1CCC(=O)NC1=O Degrader C28H24N4O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-AYT8XU WO2024165577-A1_21 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(5-chloro-2-methoxy-4-methylphenyl)carbamate COc1cc(C)c(Cl)cc1NC(=O)OCc1ccc2cc(C3CCC(=O)NC3=O)c(C)nc2c1 Degrader C25H24ClN3O5 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-0UVGGH WO2024165577-A1_22 [3-(2,6-dioxopiperidin-3-yl)-5-fluoro-2-methylquinolin-7-yl]methyl N-(3-chloro-4-methylphenyl)carbamate Cc1ccc(NC(=O)OCc2cc(F)c3cc(C4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C24H21ClFN3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-50LAMZ WO2024165577-A1_23 2-(4-tert-butylpiperidin-1-yl)-N-[[3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-6-yl]methyl]-2-oxoacetamide Cc1nc2ccc(CNC(=O)C(=O)N3CCC(C(C)(C)C)CC3)cc2cc1C1CCC(=O)NC1=O Degrader C27H34N4O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-DDXDV0 WO2024165577-A1_26 2-(3-chloro-4-methylanilino)-N-[[3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-6-yl]methyl]acetamide Cc1ccc(NCC(=O)NCc2ccc3nc(C)c(C4CCC(=O)NC4=O)cc3c2)cc1Cl Degrader C25H25ClN4O3 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-6Q4HCQ WO2024165577-A1_27 1-(3-Chloro-4-methylphenyl)-3-[[3-(2,4-dioxo-1,3-diazinan-1-yl)-2-methylquinolin-7-yl]methyl]urea Cc1ccc(NC(=O)NCc2ccc3cc(N4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C23H22ClN5O3 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-2VMMDZ WO2024165577-A1_28 [3-(2,4-dioxo-1,3-diazinan-1-yl)-2-methylquinolin-7-yl]methyl N-(3-chloro-4-methylphenyl)carbamate Cc1ccc(NC(=O)OCc2ccc3cc(N4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C23H21ClN4O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-DR9NMY WO2024165577-A1_29 [3-(2,4-dioxo-1,3-diazinan-1-yl)-2-methylquinolin-6-yl]methyl N-(3-chloro-4-methylphenyl)carbamate Cc1ccc(NC(=O)OCc2ccc3nc(C)c(N4CCC(=O)NC4=O)cc3c2)cc1Cl Degrader C23H21ClN4O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-BF7945 WO2024165577-A1_3 3-[7-[[[2-(3-Chloro-4-methylanilino)-3,4-dioxocyclobuten-1-yl]amino]methyl]-2-methylquinolin-3-yl]piperidine-2,6-dione Cc1ccc(Nc2c(NCc3ccc4cc(C5CCC(=O)NC5=O)c(C)nc4c3)c(=O)c2=O)cc1Cl Degrader C27H23ClN4O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-9JYGFZ WO2024165577-A1_30 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(3-tert-butyl-1,2-oxazol-5-yl)carbamate Cc1nc2cc(COC(=O)Nc3cc(C(C)(C)C)no3)ccc2cc1C1CCC(=O)NC1=O Degrader C24H26N4O5 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-0WAGZF WO2024165577-A1_32 N-(3-chloro-4-methylphenyl)-3-[3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]propanamide Cc1ccc(NC(=O)CCc2ccc3cc(C4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C25H24ClN3O3 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-62TDEY WO2024165577-A1_34 N-(3-chloro-4-methylphenyl)-2-[3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]oxypropanamide Cc1ccc(NC(=O)C(C)Oc2ccc3cc(C4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C25H24ClN3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-A6QJCJ WO2024165577-A1_36 N-cyclohexyl-2-[3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]oxypropanamide Cc1nc2cc(OC(C)C(=O)NC3CCCCC3)ccc2cc1C1CCC(=O)NC1=O Degrader C24H29N3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-46YLIV WO2024165577-A1_37 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(5-phenylthiophen-3-yl)carbamate Cc1nc2cc(COC(=O)Nc3csc(-c4ccccc4)c3)ccc2cc1C1CCC(=O)NC1=O Degrader C27H23N3O4S GSPT1 P15170 CRBN WO-2024165577-A1 TPD-W4F8RK WO2024165577-A1_38 . CC1=C([C@@H]2CCC(=O)NC2=O)C=C2C=CC(COC(=O)Nc3ccc(C)c(Cl)c3)=CC2N1 Degrader C24H24ClN3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-NHKGTE WO2024165577-A1_39 [3-[(3R)-2,6-dioxopiperidin-3-yl]-2-methylquinolin-7-yl]methyl N-(3-chloro-4-methylphenyl)carbamate Cc1ccc(NC(=O)OCc2ccc3cc([C@H]4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C24H22ClN3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-ADCSTC WO2024165577-A1_4 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(3-chloro-4-methylphenyl)carbamate Cc1ccc(NC(=O)OCc2ccc3cc(C4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C24H22ClN3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-D2S6VB WO2024165577-A1_42 [3-(2,6-dioxopiperidin-3-yl)-2-methylquinolin-7-yl]methyl N-(6-morpholin-4-ylpyridin-3-yl)carbamate Cc1nc2cc(COC(=O)Nc3ccc(N4CCOCC4)nc3)ccc2cc1C1CCC(=O)NC1=O Degrader C26H27N5O5 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-F7M32N WO2024165577-A1_44 . Cc1ccc(NC(=O)OCc2cc(C)c3cc(C4CCC(=O)NC4=O)c(C)nc3c2)cc1Cl Degrader C25H24ClN3O4 GSPT1 P15170 CRBN WO-2024165577-A1 TPD-ZF4JI6 SCHEMBL25442343 2-chloranyl-~{N}-[[1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]piperidin-4-yl]methyl]ethanamide\; 2-chloranyl-~{N}-[[1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]piperidin-4-yl]methyl]ethanamide; SCHEMBL25442343 CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CCC(CNC(=O)CCl)CC1 Stabilizer C18H24Cl2N2O3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-M2KCK6 WO2024192415-A1_1074203 1-[4-(4-Chloro-3-oxobutyl)piperidin-1-yl]-2-(4-chlorophenoxy)-2-methylpropan-1-one CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CCC(CCC(=O)CCl)CC1 Stabilizer C19H25Cl2NO3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-SMTSD6 SCHEMBL25443633 2-chloro-N-[2-[1-[2-(4-chlorophenoxy)-2-methylpropanoyl]piperidin-4-yl]ethyl]acetamide\; SCHEMBL25443633 CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CCC(CCNC(=O)CCl)CC1 Stabilizer C19H26Cl2N2O3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-1ZY8Q9 WO2024192415-A1_1074359 2-chloro-N-[3-[1-[2-(4-chlorophenoxy)-2-methylpropanoyl]piperidin-4-yl]propyl]acetamide CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CCC(CCCNC(=O)CCl)CC1 Stabilizer C20H28Cl2N2O3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-81216S WO2024192415-A1_1074360 2-chloro-N-[1-[2-(4-chlorophenoxy)-2-methylpropanoyl]piperidin-4-yl]acetamide CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CCC(NC(=O)CCl)CC1 Stabilizer C17H22Cl2N2O3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-5PCMVD WO2024192415-A1_1074378 2-chloro-N-[[1-[1-(4-chlorophenoxy)cyclopropanecarbonyl]piperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(C(=O)C2(Oc3ccc(Cl)cc3)CC2)CC1 Stabilizer C18H22Cl2N2O3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-EB3C2U WO2024192415-A1_1075294 2-chloro-N-[[1-[(1S,2R)-1-(4-chlorophenoxy)-2-methylcyclopropanecarbonyl]piperidin-4-yl]methyl]acetamide C[C@@H]1C[C@@]1(Oc1ccc(Cl)cc1)C(=O)N1CCC(CNC(=O)CCl)CC1 Stabilizer C19H24Cl2N2O3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-8LIVZO WO2024192415-A1_1075308 2-chloro-N-[[1-[(1S,2R)-1-(4-chlorophenoxy)-2-ethylcyclopropanecarbonyl]piperidin-4-yl]methyl]acetamide CC[C@@H]1C[C@@]1(Oc1ccc(Cl)cc1)C(=O)N1CCC(CNC(=O)CCl)CC1 Stabilizer C20H26Cl2N2O3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-590M6W WO2024192415-A1_1075314 2-chloro-N-[[1-[2-(4-chlorophenoxy)-2-cyclohexylpropanoyl]piperidin-4-yl]methyl]acetamide CC(Oc1ccc(Cl)cc1)(C(=O)N1CCC(CNC(=O)CCl)CC1)C1CCCCC1 Stabilizer C23H32Cl2N2O3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-7QJXCZ WO2024192415-A1_1075343 . CC(C)[C@@H]1C[C@@]1(Oc1ccc(Cl)cc1)C(=O)N1CCC(CNC(=O)CCl)CC1 Stabilizer C21H28Cl2N2O3 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-E94CIX S0O N-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-2-phenoxypropanamide\; S0O CC(C)(Oc1ccccc1)C(=O)Nc1cccc(-c2csc(C(=N)N)c2)c1 Stabilizer C21H21N3O2S 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-LAWEBG S0U 2-anilino-N-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methylpropanamide\; S0U CC(C)(Nc1ccccc1)C(=O)Nc1cccc(-c2csc(C(=N)N)c2)c1 Stabilizer C21H22N4OS 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-WXV6E4 RZL 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide\; 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide; RZL CC(C)(Oc1ccc(Br)cc1)C(=O)Nc1cccc(-c2csc(C(=N)N)c2)c1 Stabilizer C21H20BrN3O2S 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-N0QV44 WO2024192415-A1_Compound 13 N-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-2-[4-(trifluoromethyl)phenoxy]propanamide CC(C)(Oc1ccc(C(F)(F)F)cc1)C(=O)Nc1cccc(-c2csc(C(=N)N)c2)c1 Stabilizer C22H20F3N3O2S 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-S4LSEY RZC 2-[3,4-bis(chloranyl)phenoxy]-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide\; 2-[3,4-bis(chloranyl)phenoxy]-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide; RZC CC(C)(Oc1ccc(Cl)c(Cl)c1)C(=O)Nc1cccc(-c2csc(C(=N)N)c2)c1 Stabilizer C21H19Cl2N3O2S 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-C2ZRRP U0L N-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-chloro-3-fluorophenoxy)-2-methylpropanamide\; U0L CC(C)(Oc1ccc(Cl)c(F)c1)C(=O)Nc1cccc(-c2csc(C(=N)N)c2)c1 Stabilizer C21H19ClFN3O2S 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-8NH3M6 S3I 2-(4-acetylphenoxy)-N-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methylpropanamide\; S3I CC(=O)c1ccc(OC(C)(C)C(=O)Nc2cccc(-c3csc(C(=N)N)c3)c2)cc1 Stabilizer C23H23N3O3S 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-XCUZSB WO2024192415-A1_Compound 17 N-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-methoxyphenoxy)-2-methylpropanamide COc1ccc(OC(C)(C)C(=O)Nc2cccc(-c3csc(C(=N)N)c3)c2)cc1 Stabilizer C22H23N3O3S 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-VHYWAY WO2024192415-A1_Compound 18 4-[1-[3-(5-Carbamimidoylthiophen-3-yl)anilino]-2-methyl-1-oxopropan-2-yl]oxybenzoic acid CC(C)(Oc1ccc(C(=O)O)cc1)C(=O)Nc1cccc(-c2csc(C(=N)N)c2)c1 Stabilizer C22H21N3O4S 14-3-3σ;ERα P31947/P03372 . WO-2024192415-A1 TPD-GHHGQG SCHEMBL31191918 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2H-chromene-3-carboxamide O=C1CCC(N2CC3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC=C5)OC4)=C3)C2=O)C(=O)N1 Degrader C24H21N3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-JEJ5K8 3053857-55-6 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-6-(trifluoromethoxy)-2H-chromene-3-carboxamide; orb2944748; SCHEMBL31191952; LYG-409; EX-A12135 O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C4=CC5=C(/C=C\C(OC(F)(F)F)=C/5)OC4)=C/3)C2=O)C(=O)N1 Degrader C25H20F3N3O6 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-L0I189 SCHEMBL31191982 6-cyano-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2H-chromene-3-carboxamide N#CC1=C/C2=C(\C=C/1)OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C2 Degrader C25H20N4O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-YTZKG6 SCHEMBL31191945 6-amino-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2H-chromene-3-carboxamide NC1=C/C2=C(\C=C/1)OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C2 Degrader C24H22N4O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-Y6HHZ1 SCHEMBL31191946 6-(dimethylamino)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2H-chromene-3-carboxamide CN(C)C1=C/C2=C(\C=C/1)OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C2 Degrader C26H26N4O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-XXX0CD SCHEMBL31191907 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-6-ethenyl-2H-chromene-3-carboxamide C=CC1=C/C2=C(\C=C/1)OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C2 Degrader C26H23N3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-S5YJAJ SCHEMBL31191993 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-6-ethynyl-2H-chromene-3-carboxamide C#CC1=C/C2=C(\C=C/1)OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C2 Degrader C26H21N3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-UR3FFI SCHEMBL31191913 6-tert-butyl-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2H-chromene-3-carboxamide CC(C)(C)C1=C/C2=C(\C=C/1)OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C2 Degrader C28H29N3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-GAN5D7 SCHEMBL31191949 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-6-phenyl-2H-chromene-3-carboxamide O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C4=CC5=C(/C=C\C(C6=CC=CC=C6)=C/5)OC4)=C/3)C2=O)C(=O)N1 Degrader C30H25N3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-JZXH25 SCHEMBL31192038 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-8-(trifluoromethyl)-2H-chromene-3-carboxamide O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)/C4=C/C5=C(OC4)C(C(F)(F)F)=CC=C5)=C/3)C2=O)C(=O)N1 Degrader C25H20F3N3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-3J3U45 SCHEMBL31191960 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-8-(trifluoromethoxy)-2H-chromene-3-carboxamide O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)/C4=C/C5=C(OC4)C(OC(F)(F)F)=CC=C5)=C/3)C2=O)C(=O)N1 Degrader C25H20F3N3O6 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-LU3WWG SCHEMBL31191987 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-5-fluoro-2H-chromene-3-carboxamide O=C1CCC(N2CC3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC=C5F)OC4)=C3)C2=O)C(=O)N1 Degrader C24H20FN3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-NZ2VJR SCHEMBL31191916 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-8-methoxy-2H-chromene-3-carboxamide COC1=CC=CC2=C1OC/C(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C\2 Degrader C25H23N3O6 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-EYQLTL SCHEMBL31192063 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-8-methyl-2H-chromene-3-carboxamide CC1=CC=CC2=C1OC/C(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C\2 Degrader C25H23N3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-5P4KUH SCHEMBL31192068 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-5-methyl-2H-chromene-3-carboxamide CC1=CC=CC2=C1/C=C(/C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)CO2 Degrader C25H23N3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-HCU6WI SCHEMBL31191935 6-acetamido-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2H-chromene-3-carboxamide CC(=O)NC1=CC2=C(C=C1)OC/C(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C\2 Degrader C26H24N4O6 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-TYSX8W WO2024222918A1_A-24 . C=CC(=O)NC1=CC2=C(C=C1)OC/C(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C\2 Degrader C27H24N4O6 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-X49THW WO2024222918A1_A-25 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)/C4=C/C5=C(C=CC(NC(=O)CO)=C5)OC4)=C/3)C2=O)C(=O)N1 Degrader C26H24N4O7 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-O320AJ WO2024222918A1_A-26 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)/C4=C/C5=C(C=CC(NC(=O)C6CC6)=C5)OC4)=C/3)C2=O)C(=O)N1 Degrader C28H26N4O6 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-R5EBIU WO2024222918A1_A-27 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)/C4=C/C5=C(C=CC(NC(=O)C6CCC6)=C5)OC4)=C/3)C2=O)C(=O)N1 Degrader C29H28N4O6 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-RDPSHY WO2024222918A1_A-28 . CC1=C/C2=C(C=C(C(=O)NCC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CO2)/C=C\1Cl Degrader C25H22ClN3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-3SAFJ2 SCHEMBL31192019 7-chloro-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-6-methyl-2H-chromene-3-carboxamide CC1=C/C2=C(\C=C/1Cl)OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C2 Degrader C25H22ClN3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-ZJBPZ1 SCHEMBL31191902 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-6-fluoro-2H-chromene-3-carboxamide O=C1CCC(N2CC3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC(F)=C5)OC4)=C3)C2=O)C(=O)N1 Degrader C24H20FN3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-EYJ7J8 SCHEMBL31192029 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-7-fluoro-6-methyl-2H-chromene-3-carboxamide CC1=C/C2=C(\C=C/1F)OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C2 Degrader C25H22FN3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-6B5NPR SCHEMBL31191928 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-6-fluoro-8-methyl-2H-chromene-3-carboxamide C/C1=C/C(F)=C\C2=C1OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C3)=C2 Degrader C25H22FN3O5 GSPT1 P15170 CRBN WO-2024222918-A1 TPD-X00UE3 SCHEMBL31264456 (2E)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-methoxyimino-3-phenylpropanamide CO/N=C(\CC1=CC=CC=C1)C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H24N4O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-N99A3J SCHEMBL31264423 (2E)-2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-methoxyiminoacetamide CO/N=C(/C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2)C1=CC=C(Cl)C=C1 Degrader C23H21ClN4O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-XKR3BT WO2024251301A1_CX-11 . CO/N=C(/C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2)C1=CSC(N)=N1 Degrader C20H20N6O5S GSPT1 P15170 CRBN WO-2024251301-A1 TPD-QI2SAS SCHEMBL31264446 (2E)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-methoxyimino-3-(4-methylphenyl)propanamide CO/N=C(\CC1=CC=C(C)C=C1)C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C25H26N4O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-GR6DUL SCHEMBL31264425 (2E)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(4-fluorophenyl)-2-methoxyiminopropanamide CO/N=C(\CC1=CC=C(F)C=C1)C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H23FN4O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-DUWDFY SCHEMBL31264422 (2E)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-(3-fluorophenyl)-2-methoxyiminopropanamide CO/N=C(\CC1=CC(F)=CC=C1)C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H23FN4O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-CX7QVC SCHEMBL31264432 (2E)-3-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-methoxyiminopropanamide CO/N=C(\CC1=CC=C(Cl)C=C1)C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H23ClN4O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-F0ZCUX SCHEMBL31264420 (2E)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-methoxyimino-3-[4-(trifluoromethyl)phenyl]propanamide CO/N=C(\CC1=CC=C(C(F)(F)F)C=C1)C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C25H23F3N4O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-8X3AOW SCHEMBL31264444 (2E)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-methoxyimino-3-[4-(trifluoromethoxy)phenyl]propanamide CO/N=C(\CC1=CC=C(OC(F)(F)F)C=C1)C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C25H23F3N4O6 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-OADQJM SCHEMBL31264457 (2E)-3-(3-chloro-4-methylphenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-methoxyiminopropanamide CO/N=C(\CC1=CC(Cl)=C(C)C=C1)C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C25H25ClN4O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-78KS6T SCHEMBL31264462 (2E)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-(4-fluorophenyl)-2-methoxyiminoacetamide CO/N=C(/C(=O)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2)C1=CC=C(F)C=C1 Degrader C23H21FN4O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-W8U3E9 SCHEMBL31264415 (2E)-N-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methyl]-2-hydrazinylidene-3-phenylpropanamide N/N=C(\CC1=CC=CC=C1)C(=O)NCC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C23H21N5O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-I6ZI5F WO2024251301A1_NX-2 . N/N=C(\CC1=CC=C(F)C=C1)C(=O)NCC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C23H20FN5O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-RLUBL8 WO2024251301A1_NX-3 . CC1=CC=C(C/C(=N\N)C(=O)NCC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C24H23N5O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-DJC57G WO2024251301A1_NX-4 . N/N=C(\CC1=CC=C(OC(F)(F)F)C=C1)C(=O)NCC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C24H20F3N5O6 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-LFGB7J WO2024251301A1_NX-5 . N/N=C(\CC1=CC=C(Cl)C=C1)C(=O)NCC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C23H20ClN5O5 GSPT1 P15170 CRBN WO-2024251301-A1 TPD-KOHUUB WO2024255810A1_1 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C=NN3C=C2)CCN1CC1CCN(C2=C(F)C=C(C#N)C=C2)CC1 Degrader C30H35FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-W0L6JJ WO2024255810A1_10 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=NC=C(F)C=C2)CC1 Degrader C28H35FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-DQRYJW WO2024255810A1_100 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1C[C@H]1CC[C@H](C2=NN(C)C=C2)CC1 Degrader C28H37FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-2T5380 WO2024255810A1_101 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(C2=CN(C)N=C2)CC1 Degrader C28H37FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-XRHCMJ WO2024255810A1_102 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(C2=CC=NN2C)CC1 Degrader C28H37FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-8ET5ZK WO2024255810A1_103 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(C2=N/N3CCC\C3=C\2)CC1 Degrader C30H39FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-PYANPG WO2024255810A1_104 . CC1=CN(C)N=C1C1CCC(CN2CCN(CC3=CC4=C(N5CCC(=O)NC5=O)C(F)=NN4C=C3)C[C@@H]2C)CC1 Degrader C29H39FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-7Q2U5K WO2024255810A1_105 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(C2=NN(C(F)F)C=C2)CC1 Degrader C28H35F3N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-EGN05G WO2024255810A1_106 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(C2=NN(C3CC3)C=C2)CC1 Degrader C30H39FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-NLN0M0 WO2024255810A1_107 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(C2=NN(C)C=C2F)CC1 Degrader C28H36F2N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-K5B0RS WO2024255810A1_108 . CC1=NC=C(C2CCC(CN3CCN(CC4=CC5=C(N6CCC(=O)NC6=O)C(F)=NN5C=C4)C[C@@H]3C)CC2)C=N1 Degrader C29H37FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-57ZE5L WO2024255810A1_109 . CCN1C=CC(C2CCC(CN3CCN(CC4=CC5=C(N6CCC(=O)NC6=O)C(F)=NN5C=C4)C[C@@H]3C)CC2)=N1 Degrader C29H39FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-UR87SB WO2024255810A1_11 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=CC=C(C#N)C=C2)CC1 Degrader C30H36N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-NCET78 WO2024255810A1_13 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=NC=C(Cl)C=C2)CC1 Degrader C28H35ClN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-CRQLGE WO2024255810A1_131 . CCN1C=CC(C2CCC(N3CCN(CC4=CC5=C(N6CCC(=O)NC6=O)C(F)NN5C=C4)C[C@@H]3C)CC2)=N1 Degrader C28H39FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-GNC0A5 WO2024255810A1_132 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1C1CCC(C2=NN(C)C=C2)CC1 Degrader C27H35FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-2J2PO9 WO2024255810A1_133 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1C1CCC(C2=NN(C(F)F)C=C2)CC1 Degrader C27H33F3N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-T6E7AR WO2024255810A1_134 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1C1CCN(C2=C(F)C=C(C#N)C=C2)CC1 Degrader C29H32F2N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-KG95O7 WO2024255810A1_135 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1C1CCN(C2=CC=C(F)C=C2)CC1 Degrader C28H33F2N7O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-21NTUG WO2024255810A1_136 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1C1CCN(C2=C(F)C=C(F)C=C2)CC1 Degrader C28H32F3N7O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-IQUKQC WO2024255810A1_137 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1C1CCN(C2=C(Cl)C=C(C#N)C=C2)CC1 Degrader C29H32ClFN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-PY860A WO2024255810A1_138 . CC(C1CCC1)N1CCN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C(F)=N\N3C=C2)C[C@@H]1C Degrader C23H31FN6O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-R7ZNZ9 WO2024255810A1_14 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=CN=C(C#N)C=C2)CC1 Degrader C29H35N9O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-VMH4KH WO2024255810A1_140 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1C[C@H]1CC[C@H](N2C=C(F)C=N2)CC1 Degrader C27H34F2N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-8AERL1 WO2024255810A1_141 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1C[C@H]1CC[C@@H](N2C=C(F)C=N2)CC1 Degrader C27H34F2N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-51KZRJ WO2024255810A1_142 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(N2C=C(C(F)(F)F)C=N2)CC1 Degrader C28H34F4N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-0NCX7Z WO2024255810A1_143 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(N2C=C(Cl)C=N2)CC1 Degrader C27H34ClFN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-Y9A5PG WO2024255810A1_144 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(N2C=CC(C3CC3)=N2)CC1 Degrader C30H39FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-4UP490 WO2024255810A1_145 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCC(N2C=CC(C(F)(F)F)=N2)CC1 Degrader C28H34F4N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-NZV3UP WO2024255810A1_146 . CC1=NN(C2CCC(CN3CCN(CC4=CC5=C(N6CCC(=O)NC6=O)C(F)=NN5C=C4)C[C@@H]3C)CC2)C=C1Cl Degrader C28H36ClFN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-EZKDN0 WO2024255810A1_15 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C=NN3C=C2)CCN1CC1CCN(C2=C(F)C=NC=C2)CC1 Degrader C28H35FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-T8NZDZ WO2024255810A1_161 . CC1=CN(C2CCC(N3CCN(CC4=CC5=C(N6CCC(=O)NC6=O)C(F)=NN5C=C4)C[C@@H]3C)CC2)N=C1 Degrader C27H35FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-OT9BNW WO2024255810A1_162 . CC(C)S(=O)(=O)N1CCC(CN2CCN(CC3=CC4=C(N5CCC(=O)NC5=O)C(F)=NN4C=C3)C[C@@H]2C)CC1 Degrader C26H38FN7O4S WIZ O95785 CRBN WO-2024255810-A1 TPD-D5WQVK WO2024255810A1_163 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C(F)=NN3C=C2)CCN1CC1CCN(C(=O)C2CC2)CC1 Degrader C27H36FN7O3 WIZ O95785 CRBN WO-2024255810-A1 TPD-67N5R1 WO2024255810A1_164 . CC(C)OC(=O)N1CCC(CN2CCN(CC3=C/C4=C(N5CCC(=O)NC5=O)/C(F)=N\N4C=C3)C[C@@H]2C)CC1 Degrader C27H38FN7O4 WIZ O95785 CRBN WO-2024255810-A1 TPD-S24UEF WO2024255810A1_165 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C(F)=N\N3C=C2)CCN1CC1CCN(C(=O)N(C)C)CC1 Degrader C26H37FN8O3 WIZ O95785 CRBN WO-2024255810-A1 TPD-Q1FO1K WO2024255810A1_17 . C[C@H]1CN(CC2=CC3=C(C=C2)O/C=C\3N2CCC(=O)NC2=O)CCN1CC1CCN(C2=NC=C(C#N)C=C2)CC1 Degrader C30H35N7O3 WIZ O95785 CRBN WO-2024255810-A1 TPD-0OK9EL WO2024255810A1_2 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C=NN3C=C2)CCN1CC1CCC(C2=CC=C(F)C=C2)CC1 Degrader C30H37FN6O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-S507GK WO2024255810A1_20 . CC(C)CN1CCN(CC2=CC3=C(C=C2F)O/N=C\3N2CCC(=O)NC2=O)C[C@@H]1C Degrader C21H28FN5O3 WIZ O95785 CRBN WO-2024255810-A1 TPD-UBFKEM WO2024255810A1_21 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=CC=C(C#N)C(F)=C2)CC1 Degrader C30H35FN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-KJYONP WO2024255810A1_22 . COC1=CN=C(N2CCC(CN3CCN(CC4=C/C5=C(N6CCC(=O)NC6=O)/C=N\N5C=C4)C[C@@H]3C)CC2)C=C1 Degrader C29H38N8O3 WIZ O95785 CRBN WO-2024255810-A1 TPD-6R4SHZ WO2024255810A1_23 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=CC=C(Cl)C=C2)CC1 Degrader C29H36ClN7O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-GPVSC5 WO2024255810A1_24 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=NC=CC=N2)CC1 Degrader C27H35N9O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-OFFCSN WO2024255810A1_25 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=NC=C(Cl)C=N2)CC1 Degrader C27H34ClN9O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-RRDPJ4 WO2024255810A1_26 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=C(F)C=C(F)C=C2)CC1 Degrader C29H35F2N7O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-JCG1CV WO2024255810A1_27 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=CC(Cl)=CC=N2)CC1 Degrader C28H35ClN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-A9J84J WO2024255810A1_3 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C=NN3C=C2)CCN1CC1CCN(C2=CC=C(F)C=C2)CC1 Degrader C29H36FN7O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-OE7MEC WO2024255810A1_30 . CC1=CC=C(N2CCC(CN3CCN(CC4=C/C5=C(N6CCC(=O)NC6=O)/C=N\N5C=C4)C[C@@H]3C)CC2)N=C1 Degrader C29H38N8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-Q2VCZE WO2024255810A1_31 . CC1=CC(N2CCC(CN3CCN(CC4=C/C5=C(N6CCC(=O)NC6=O)/C=N\N5C=C4)C[C@@H]3C)CC2)=NC=C1Cl Degrader C29H37ClN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-3D77X8 WO2024255810A1_32 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=NC=NC=C2)CC1 Degrader C27H35N9O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-38VYOH WO2024255810A1_33 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C=NN3C=C2)CCN1CC1CCN(C2=NC=CN=C2)CC1 Degrader C27H35N9O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-2XCYVT WO2024255810A1_34 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=NC=CS2)CC1 Degrader C26H34N8O2S WIZ O95785 CRBN WO-2024255810-A1 TPD-6HT58O WO2024255810A1_35 . CC1=C(N2CCC(CN3CCN(CC4=C/C5=C(N6CCC(=O)NC6=O)/C=N\N5C=C4)C[C@@H]3C)CC2)N=CC(Cl)=C1 Degrader C29H37ClN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-SKEG23 WO2024255810A1_37 . CC1=C(Cl)C=CC(N2CCC(CN3CCN(CC4=CC5=C(N6CCC(=O)NC6=O)C=NN5C=C4)C[C@@H]3C)CC2)=N1 Degrader C29H37ClN8O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-C497G3 WO2024255810A1_38 . C[C@H]1CN(CC2=C/C3=C(N4CCC(=O)NC4=O)/C=N\N3C=C2)CCN1CC1CCN(C2=NN=CC=C2)CC1 Degrader C27H35N9O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-R38A2Y WO2024255810A1_39 . C[C@H]1CN(CC2=CC3=C(C=C2)O/C=C\3N2CCC(=O)NC2=O)CCN1CC1CCN(C2=CC=C(Cl)C=N2)CC1 Degrader C29H35ClN6O3 WIZ O95785 CRBN WO-2024255810-A1 TPD-1E6XRY WO2024255810A1_4 . C[C@H]1CN(CC2=CC3=C(N4CCC(=O)NC4=O)C=NN3C=C2)CCN1CC1CCN(C2=NC=C(C#N)C=C2)CC1 Degrader C29H35N9O2 WIZ O95785 CRBN WO-2024255810-A1 TPD-SE27G7 WO2024255810A1_40 . C[C@H]1CN(CC2=CC3=C(C=C2)O/C=C\3N2CCC(=O)NC2=O)CCN1CC1CCN(C2=CC=C(C#N)C=C2)CC1 Degrader C31H36N6O3 WIZ O95785 CRBN WO-2024255810-A1 TPD-62I3PQ WO2024255810A1_41 . C[C@H]1CN(CC2=CC3=C(C=C2)O/C=C\3N2CCC(=O)NC2=O)CCN1CC1CCN(C2=NC=CC=N2)CC1 Degrader C28H35N7O3 WIZ O95785 CRBN WO-2024255810-A1 TPD-650UFZ WO2025040546A1_100-1 . O=C(CC1=CN(C2=CC=NC=C2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C16H16N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-9E3T9O WO2025040546A1_100-10 . CC1=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=NC=C1 Degrader C17H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-A6IZRQ WO2025040546A1_100-11 . O=C(CC1=CN(C2=CC=CC(Cl)=C2)N=C1)NC1=NNC(C2CCC2)=C1 Degrader C18H18ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-Z3HNXA WO2025040546A1_100-12 . C[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H18ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-C5I3VE WO2025040546A1_100-13 . O=C(CC1=CN(C2=CC(F)=CC(F)=C2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C17H15F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-OTR5O1 WO2025040546A1_100-14 . C[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H18ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-KUI4D3 WO2025040546A1_100-2 . CC1=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1F Degrader C18H18FN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LB1RI9 WO2025040546A1_100-3 . O=C(CC1=CN(C2=NC=CC=C2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C16H16N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-J5EAPX WO2025040546A1_100-4 . N#CC1=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1 Degrader C18H16N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-DY0VMI WO2025040546A1_100-5 . COC1=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1 Degrader C18H19N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-W44AMJ WO2025040546A1_100-6 . O=C(CC1=CN(C2=CC=CC(Cl)=C2)N=C1)NC1=CC(C2CCC2)=NN1 Degrader C18H18ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-93YRBZ WO2025040546A1_100-7 . CC1=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1F Degrader C18H18FN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-Y41IQ0 WO2025040546A1_100-8 . O=C(CC1=CN(C2=CC(F)=CC(F)=C2)N=C1)NC1=CC(C2CC2)=NN1 Degrader C17H15F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-WF4NAN WO2025040546A1_100-9 . N#CC1=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1 Degrader C18H16N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-X4PFYG WO2025040546A1_101-1 . CC1=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=NC=C1 Degrader C17H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-IBJCHK WO2025040546A1_101-10 . C[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=C(F)C(F)=C2)N=C1 Degrader C18H17F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-YEJZ1F WO2025040546A1_101-11 . COCC1=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1 Degrader C19H21N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-MPYW12 WO2025040546A1_101-12 . C[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H17F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-9GTQXI WO2025040546A1_101-13 . C[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=C(F)C(F)=C2)N=C1 Degrader C18H17F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-SZJ4TC WO2025040546A1_101-14 . C[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H17F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-BMS4NB WO2025040546A1_101-2 . O=C(CC1=CN(C2=NC=CC(Cl)=C2)N=C1)NC1=CC(C2CC2)=NN1 Degrader C16H15ClN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-ZD1P54 WO2025040546A1_101-3 . C[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H18ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-2NHSR6 WO2025040546A1_101-4 . CN(C)CC1=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1 Degrader C20H24N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-HSQBTQ WO2025040546A1_101-5 . C[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H18ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-383RWI WO2025040546A1_101-6 . COCC1=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1 Degrader C19H21N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-5IKOFH WO2025040546A1_101-7 . O=C(CC1=CN(C2=NC=CC(Cl)=C2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C16H15ClN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-PUNYW5 WO2025040546A1_101-8 . C[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=C(F)C(F)=C2)N=C1 Degrader C18H17F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-2EY5N0 WO2025040546A1_101-9 . CN(C)CC1=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1 Degrader C20H24N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-DXU67G WO2025040546A1_102-1 . C[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=C(F)C(F)=C2)N=C1 Degrader C18H17F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-YIHOD2 WO2025040546A1_102-10 . C[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=C(F)C(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-YCAIPE WO2025040546A1_102-11 . CN(C)C1=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=NC=C1 Degrader C18H21N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-UNOPZT WO2025040546A1_102-12 . C[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=C(F)C(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LYUIW8 WO2025040546A1_102-13 . COC1=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=NC=C1 Degrader C17H18N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-4C47ZC WO2025040546A1_102-14 . CN(C)C1=CC=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=N1 Degrader C18H21N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-3LF3CD WO2025040546A1_102-2 . O=C(CC1=CN(C2=NC(Cl)=CC=C2)N=C1)NC1=CC(C2CC2)=NN1 Degrader C16H15ClN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-5QU5NP WO2025040546A1_102-3 . C[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H17F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-04MF9M WO2025040546A1_102-4 . CC1=CC=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=N1 Degrader C17H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-3CO3HH WO2025040546A1_102-5 . C[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H17F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-MX4AOV WO2025040546A1_102-6 . CN(C)C1=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=NC=C1 Degrader C18H21N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-IYRX7I WO2025040546A1_102-7 . O=C(CC1=CN(C2=NC(Cl)=CC=C2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C16H15ClN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-W67OK7 WO2025040546A1_102-8 . COC1=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=NC=C1 Degrader C17H18N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-FBTCVM WO2025040546A1_102-9 . CC1=CC=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=N1 Degrader C17H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-RDEOT5 WO2025040546A1_103-1 . C[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=C(F)C(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-32ZNMB WO2025040546A1_103-10 . CC1=CSC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=N1 Degrader C15H16N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-J92AKE WO2025040546A1_103-11 . O=C(CC1=CN(C2=NC=CS2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C14H14N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-MZ5B1R WO2025040546A1_103-12 . C[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=CC(C#N)=C2)N=C1 Degrader C19H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-N9Q1B7 WO2025040546A1_103-13 . O=C(CC1=CN(C2=CSC=N2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C14H14N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-G294DZ WO2025040546A1_103-14 . C[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=CC(C#N)=C2)N=C1 Degrader C19H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-FVM6O3 WO2025040546A1_103-2 . COC1=CC=CC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=N1 Degrader C17H18N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-U09UAC WO2025040546A1_103-3 . C[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=C(F)C(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-Y76WXB WO2025040546A1_103-4 . CC1=CN=C(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)S1 Degrader C15H16N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-9O3XYH WO2025040546A1_103-5 . CN(C)C1=CC=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=N1 Degrader C18H21N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-U5R1CB WO2025040546A1_103-6 . O=C(CC1=CN(C2=NC=CS2)N=C1)NC1=CC(C2CC2)=NN1 Degrader C14H14N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-T4EFSK WO2025040546A1_103-7 . COC1=CC=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=N1 Degrader C17H18N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-E5ULL5 WO2025040546A1_103-8 . O=C(CC1=CN(C2=CSC=N2)N=C1)NC1=CC(C2CC2)=NN1 Degrader C14H14N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-INNON6 WO2025040546A1_103-9 . CC1=CN=C(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)S1 Degrader C15H16N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-3Q0XCV WO2025040546A1_104-1 . CC1=CSC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=N1 Degrader C15H16N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-VP4GY2 WO2025040546A1_104-10 . C[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=C(F)C(C#N)=C2)N=C1 Degrader C19H17FN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-11O8R4 WO2025040546A1_104-11 . CC1=NC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=CS1 Degrader C15H16N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-5E0ZK6 WO2025040546A1_104-12 . C[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=C(F)C(C#N)=C2)N=C1 Degrader C19H17FN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-QERXOZ WO2025040546A1_104-13 . CC1=NC=C(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)S1 Degrader C15H16N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-8CJ4B6 WO2025040546A1_104-14 . C[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC(F)=CC(C#N)=C2)N=C1 Degrader C19H17FN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-DYLSVJ WO2025040546A1_104-2 . CC1=CN=C(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)C=C1Cl Degrader C17H17ClN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-AXUQBC WO2025040546A1_104-3 . C[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=CC(C#N)=C2)N=C1 Degrader C19H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-SRQH0B WO2025040546A1_104-4 . O=C(CC1=CN(C2=CSC(Cl)=N2)N=C1)NC1=CC(C2CC2)=NN1 Degrader C14H13ClN6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-12YBZM WO2025040546A1_104-5 . C[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=CC(C#N)=C2)N=C1 Degrader C19H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LAH1I4 WO2025040546A1_104-6 . CC1=NC(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)=CS1 Degrader C15H16N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-2WG2EI WO2025040546A1_104-7 . CC1=CN=C(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)C=C1Cl Degrader C17H17ClN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-SQDJF3 WO2025040546A1_104-8 . CC1=NC=C(N2C=C(CC(=O)NC3=CC(C4CC4)=NN3)C=N2)S1 Degrader C15H16N6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-GSJPW6 WO2025040546A1_104-9 . O=C(CC1=CN(C2=CSC(Cl)=N2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C14H13ClN6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-5FJ04P WO2025040546A1_105-1 . C[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=C(F)C(C#N)=C2)N=C1 Degrader C19H17FN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LATXAP WO2025040546A1_105-10 . O=C(CC1=CN(C2=CN=C(Cl)S2)N=C1)NC1=CC(C2CC2)=NN1 Degrader C14H13ClN6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-M39XEV WO2025040546A1_105-11 . CC1=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1Cl Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-2HZK64 WO2025040546A1_105-12 . CC1=CC=C(N2C=C([C@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)C=C1Cl Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-VF9RK2 WO2025040546A1_105-13 . O=C(CC1=CN(C2=NC(Cl)=CS2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C14H13ClN6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-V9OCQW WO2025040546A1_105-14 . CC1=CC=C(N2C=C([C@@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)C=C1Cl Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-Q6EDCK WO2025040546A1_105-2 . C[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC(F)=CC(C#N)=C2)N=C1 Degrader C19H17FN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-C4GEEA WO2025040546A1_105-3 . C[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=C(F)C(C#N)=C2)N=C1 Degrader C19H17FN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-EM3N8F WO2025040546A1_105-4 . CC1=CC(N2C=C([C@@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1Cl Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-DIVFD4 WO2025040546A1_105-5 . C[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC(F)=CC(C#N)=C2)N=C1 Degrader C19H17FN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-D4X9H5 WO2025040546A1_105-6 . CC1=CC(N2C=C([C@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1Cl Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-TKVMDQ WO2025040546A1_105-7 . C[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC(F)=CC(C#N)=C2)N=C1 Degrader C19H17FN6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-VCFPLL WO2025040546A1_105-8 . O=C(CC1=CN(C2=NC(Cl)=CS2)N=C1)NC1=CC(C2CC2)=NN1 Degrader C14H13ClN6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-Y5BTRY WO2025040546A1_105-9 . CC1=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1Cl Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-URBZW0 WO2025040546A1_106-1 . O=C(CC1=CN(C2=CN=C(Cl)S2)N=C1)NC1=NNC(C2CC2)=C1 Degrader C14H13ClN6OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-ZPF9HT WO2025040546A1_106-10 . CC[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-QC0W6C WO2025040546A1_106-11 . C[C@H](C(=O)NC1=NNC(C2CCC2)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-NYG1VN WO2025040546A1_106-12 . CC[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-0OVSH1 WO2025040546A1_106-2 . CC1=CC(Cl)=CC(N2C=C([C@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-DCS0C2 WO2025040546A1_106-3 . CC1=CC=C(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)C=C1Cl Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-TCXTZ3 WO2025040546A1_106-4 . CC1=CC(Cl)=CC(N2C=C([C@@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-WMO5NG WO2025040546A1_106-5 . CC1=CC=C(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)C=C1Cl Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-TFGL00 WO2025040546A1_106-6 . C[C@H](C(=O)NC1=CC(C2CCC2)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-P2EQBZ WO2025040546A1_106-7 . CC1=CC(Cl)=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-55C1UC WO2025040546A1_106-8 . C[C@@H](C(=O)NC1=CC(C2CCC2)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-EJOPU1 WO2025040546A1_106-9 . CC1=CC(Cl)=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-INO9SB WO2025040546A1_107-1 . C[C@@H](C(=O)NC1=NNC(C2CCC2)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-T219WY WO2025040546A1_107-10 . COC1=CC(N2C=C([C@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=NC=C1 Degrader C18H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LZ94CC WO2025040546A1_107-11 . C[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC(F)=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-I593TF WO2025040546A1_107-12 . COC1=CC(N2C=C([C@@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=NC=C1 Degrader C18H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-S4A71I WO2025040546A1_107-2 . COC1=CC=CC(N2C=C([C@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=N1 Degrader C18H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-CMDSK8 WO2025040546A1_107-3 . CC[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-YSXZ4V WO2025040546A1_107-4 . COC1=CC=CC(N2C=C([C@@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=N1 Degrader C18H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-MO1EDK WO2025040546A1_107-5 . CC[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H20ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-84GKS6 WO2025040546A1_107-6 . C[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC(F)=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-702QB6 WO2025040546A1_107-7 . COC1=CC=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=N1 Degrader C18H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-QC8IL9 WO2025040546A1_107-8 . C[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC(F)=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LIMJR8 WO2025040546A1_107-9 . COC1=CC=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=N1 Degrader C18H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-HCPQLT WO2025040546A1_108-1 . C[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC(F)=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-R6XVS6 WO2025040546A1_108-10 . CC1=CC(N2C=C([C@@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1F Degrader C19H20FN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-NXRNLA WO2025040546A1_108-11 . COCC1=CC(N2C=C([C@@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1 Degrader C20H23N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-97JSY2 WO2025040546A1_108-12 . CC1=CC(N2C=C([C@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1F Degrader C19H20FN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-IFUSBW WO2025040546A1_108-13 . COCC1=CC(N2C=C([C@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=CC=C1 Degrader C20H23N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-ML519G WO2025040546A1_108-14 . C[C@H](C(=O)NC1=CC(C2CC(F)(F)C2)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H18ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-TZ9ECH WO2025040546A1_108-2 . COC1=CC(Cl)=CC(N2C=C([C@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=C1 Degrader C19H20ClN5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-I40R0X WO2025040546A1_108-3 . COC1=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=NC=C1 Degrader C18H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-7T4D3Y WO2025040546A1_108-4 . COC1=CC(Cl)=CC(N2C=C(CC(=O)NC3=NNC(C4CC4)=C3)C=N2)=C1 Degrader C18H18ClN5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-9ZJ6Q5 WO2025040546A1_108-5 . COC1=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=NC=C1 Degrader C18H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-5TUEYN WO2025040546A1_108-6 . COCC1=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1 Degrader C20H23N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-DME2R0 WO2025040546A1_108-7 . COC1=CC(Cl)=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C19H20ClN5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-FPU1Q9 WO2025040546A1_108-8 . COCC1=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1 Degrader C20H23N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-661766 SCHEMBL31516912 (2R)-2-[1-(3-chloro-5-methoxyphenyl)pyrazol-4-yl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)propanamide; SCHEMBL31517417 COC1=CC(Cl)=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C19H20ClN5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-F0BPKZ WO2025040546A1_109-1 . CC1=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1F Degrader C19H20FN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-L0FKJW WO2025040546A1_109-10 . C[C@@H](C(=O)NC1=CC([C@H]2CC2(F)F)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H16ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-FNIN83 WO2025040546A1_109-11 . C[C@H](C(=O)NC1=NNC(C(C)(C)C)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H22ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-HS704K WO2025040546A1_109-12 . C[C@H](C(=O)NC1=CC([C@@H]2CC2(F)F)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H16ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-MSMTXP WO2025040546A1_109-13 . C[C@@H](C(=O)NC1=NNC([C@@H]2CC2(F)F)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H16ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-C6BJI9 WO2025040546A1_109-14 . C[C@H](C(=O)NC1=CC([C@H]2CC2(F)F)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H16ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-PGY89F WO2025040546A1_109-2 . C[C@@H](C(=O)NC1=CC(C2CC(F)(F)C2)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H18ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LCMD9V WO2025040546A1_109-3 . CC1=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=CC=C1F Degrader C19H20FN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-6FS332 WO2025040546A1_109-4 . C[C@@H](C(=O)NC1=CC(C(C)(C)C)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H22ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-9XDF6B WO2025040546A1_109-5 . C[C@H](C(=O)NC1=NNC(C2CC(F)(F)C2)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H18ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-FZUEID WO2025040546A1_109-6 . C[C@H](C(=O)NC1=CC(C(C)(C)C)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H22ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-R6Q7J3 WO2025040546A1_109-7 . C[C@@H](C(=O)NC1=NNC(C2CC(F)(F)C2)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H18ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-UM1PIQ WO2025040546A1_109-8 . C[C@@H](C(=O)NC1=CC([C@@H]2CC2(F)F)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H16ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-03P3MD WO2025040546A1_109-9 . C[C@@H](C(=O)NC1=NNC(C(C)(C)C)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C19H22ClN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-YFNI3S WO2025040546A1_110-1 . C[C@@H](C(=O)NC1=NNC([C@H]2CC2(F)F)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H16ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-UJW22M WO2025040546A1_110-10 . C[C@@H](C(=O)NC1=CC([C@H]2C[C@@H]2F)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-4FZJ4K WO2025040546A1_110-11 . C[C@@H](C(=O)NC1=NNC([C@@H]2C[C@H]2F)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-8AA75X WO2025040546A1_110-12 . C[C@H](C(=O)NC1=CC([C@H]2C[C@@H]2F)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-J0NMEO WO2025040546A1_110-2 . C[C@@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=C(C#N)C=C2)N=C1 Degrader C19H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-UUJSN7 WO2025040546A1_110-3 . C[C@H](C(=O)NC1=NNC([C@@H]2CC2(F)F)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H16ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-K35BZ9 WO2025040546A1_110-4 . C[C@H](C(=O)NC1=NNC(C2CC2)=C1)C1=CN(C2=CC=C(C#N)C=C2)N=C1 Degrader C19H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-60T1MU WO2025040546A1_110-5 . C[C@H](C(=O)NC1=NNC([C@H]2CC2(F)F)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H16ClF2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-BFKQBS WO2025040546A1_110-6 . C[C@@H](C(=O)NC1=CC([C@@H]2C[C@H]2F)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-IMMWRD WO2025040546A1_110-7 . C[C@@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=C(C#N)C=C2)N=C1 Degrader C19H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-T9Z02G WO2025040546A1_110-8 . C[C@H](C(=O)NC1=CC([C@@H]2C[C@H]2F)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-ROOQ03 WO2025040546A1_110-9 . C[C@H](C(=O)NC1=CC(C2CC2)=NN1)C1=CN(C2=CC=C(C#N)C=C2)N=C1 Degrader C19H18N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-X49LMR WO2025040546A1_111-1 . C[C@H](C(=O)NC1=NNC([C@@H]2C[C@H]2F)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-U5Q0GM WO2025040546A1_111-10 . CC1=CC(C#N)=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C20H20N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-RMVWLM WO2025040546A1_111-11 . C[C@@H](C(=O)NC1=NNC([C@@H]2CC2(F)F)=C1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H15F4N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-G9MW3V WO2025040546A1_111-12 . CC1=CC(C#N)=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C20H20N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-Z10X39 WO2025040546A1_111-13 . C[C@H](C(=O)NC1=NNC([C@@H]2CC2(F)F)=C1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H15F4N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-4S7RHK WO2025040546A1_111-14 . CC1=CC(F)=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C19H20FN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-ZTL43R SCHEMBL31516936 (2R)-N-[5-[(1R)-2,2-difluorocyclopropyl]-1H-pyrazol-3-yl]-2-[1-(3,5-difluorophenyl)pyrazol-4-yl]propanamide; SCHEMBL31517394 C[C@@H](C(=O)NC1=CC([C@H]2CC2(F)F)=NN1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H15F4N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-TMJQA8 WO2025040546A1_111-3 . C[C@@H](C(=O)NC1=NNC([C@H]2C[C@@H]2F)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LU09D3 WO2025040546A1_111-4 . C[C@H](C(=O)NC1=CC([C@H]2CC2(F)F)=NN1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H15F4N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-52G0JT WO2025040546A1_111-5 . C[C@H](C(=O)NC1=NNC([C@H]2C[C@@H]2F)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H17ClFN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-4NY9LJ WO2025040546A1_111-6 . C[C@@H](C(=O)NC1=CC([C@@H]2CC2(F)F)=NN1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H15F4N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-U1E4C5 WO2025040546A1_111-7 . O=C(CC1=CN(C2=CC(F)=CC(F)=C2)N=C1)NC1=NNC([C@H]2CC2(F)F)=C1 Degrader C17H13F4N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-SMYE7U SCHEMBL31517525 (2S)-N-[5-[(1S)-2,2-difluorocyclopropyl]-1H-pyrazol-3-yl]-2-[1-(3,5-difluorophenyl)pyrazol-4-yl]propanamide; SCHEMBL31517675 C[C@H](C(=O)NC1=CC([C@@H]2CC2(F)F)=NN1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H15F4N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LGWE1J WO2025040546A1_111-9 . C[C@H](C(=O)NC1=NNC([C@H]2CC2(F)F)=C1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H15F4N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-LQTW7E WO2025040546A1_112-1 . CC1=CC(C#N)=CC(N2C=C([C@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=C1 Degrader C20H20N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-7Y7GCL WO2025040546A1_112-10 . C[C@H](C(=O)NC1=CC(C2COC2)=NN1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H17F2N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-CFE2NL WO2025040546A1_112-11 . C[C@@H](C(=O)NC1=NNC(C2COC2)=C1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H18ClN5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-HO96PB WO2025040546A1_112-12 . COC1=CC(C#N)=CC(N2C=C([C@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C20H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-7929NY WO2025040546A1_112-13 . C[C@@H](C(=O)NC1=NNC(C2COC2)=C1)C1=CN(C2=CC(F)=CC(F)=C2)N=C1 Degrader C18H17F2N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-R6JNSF WO2025040546A1_112-14 . COC1=CC(C#N)=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C20H20N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-SOUCBY WO2025040546A1_112-2 . CC1=CC(F)=CC(N2C=C([C@@H](C)C(=O)NC3=CC(C4CC4)=NN3)C=N2)=C1 Degrader C19H20FN5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-HII7TL WO2025040546A1_112-3 . CC1=CC(C#N)=CC(N2C=C([C@@H](C)C(=O)NC3=NNC(C4CC4)=C3)C=N2)=C1 Degrader C20H20N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-08HBQA WO2025040546A1_112-4 . C[C@H](C(=O)NC1=CC(C2COC2)=NN1)C1=CN(C2=CC=CC(Cl)=C2)N=C1 Degrader C18H18ClN5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2025040546-A1 TPD-WYYCTP SCHEMBL31534735 (3S)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CC[C@H](N2NC3=C(C=CC=C3OCC3=CC=C(CN4CCOCC4)C=C3)C2=O)C(=O)N1 Degrader C24H26N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-2B1H0S SCHEMBL31534736 3-[7-[[4-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC=C3OCC3=CC=C(CN4CCN(C5=CC=C(F)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C30H30FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-UH234B SCHEMBL31534781 3-[3-oxo-7-[[4-[[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]phenyl]methoxy]-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC=C3OCC3=CC=C(CN4CCN(C5=CC=C(C(F)(F)F)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C31H30F3N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-O1VKQP SCHEMBL31534737 3-[7-[[4-[[4-(2,4-dichlorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC=C3OCC3=CC=C(CN4CCN(C5=C(Cl)C=C(Cl)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C30H29Cl2N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-7XGCJQ SCHEMBL31534743 3-[7-[[4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methoxy]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC=C3OCC3=CC=C(CN4CC(N5CCOCC5)C4)C=C3)C2=O)C(=O)N1 Degrader C27H31N5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-HY1CA2 SCHEMBL31534766 4-[4-[[4-[[2-(2,6-dioxopiperidin-3-yl)-5-fluoro-3-oxo-1H-indazol-7-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile N#CC1=CC(F)=C(N2CCN(CC3=CC=C(COC4=CC(F)=CC5=C4NN(C4CCC(=O)NC4=O)C5=O)C=C3)CC2)C=C1 Degrader C31H28F2N6O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-JMGZ0H SCHEMBL31534748 3-[7-[[4-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-5-fluoro-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=C(F)C=C3OCC3=CC=C(CN4CCN(C5=C(F)C=C(F)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C30H28F3N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-XDOO1I SCHEMBL31534773 3-[7-[[4-[[4-(2,4-dichlorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-5-fluoro-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=C(F)C=C3OCC3=CC=C(CN4CCN(C5=C(Cl)C=C(Cl)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C30H28Cl2FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-3ABZG4 SCHEMBL31534758 3-[5-fluoro-3-oxo-7-[[4-[[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]phenyl]methoxy]-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=C(F)C=C3OCC3=CC=C(CN4CCN(C5=CC=C(C(F)(F)F)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C31H29F4N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-79HGDO SCHEMBL31534745 3-[7-[[4-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-5-fluoro-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=C(F)C=C3OCC3=CC=C(CN4CCN(C5=CC=C(Cl)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C30H29ClFN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-2LTC5K SCHEMBL31534740 3-[5-fluoro-7-[[4-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=C(F)C=C3OCC3=CC=C(CN4CCN(C5=CC=C(F)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C30H29F2N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-1F7S3W WO2025056073A1_D2 . N#CC1=CC(F)=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4NN([C@H]4CCC(=O)NC4=O)C5=O)C=C3)CC2)C=C1 Degrader C31H29FN6O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-AI43N9 SCHEMBL31534768 3-[5-fluoro-7-[[4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methoxy]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=C(F)C=C3OCC3=CC=C(CN4CC(N5CCOCC5)C4)C=C3)C2=O)C(=O)N1 Degrader C27H30FN5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-WC0GTG SCHEMBL31534762 3-[7-[[4-[[4-(4-chloro-2-fluorophenyl)piperazin-1-yl]methyl]phenyl]methoxy]-5-fluoro-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=C(F)C=C3OCC3=CC=C(CN4CCN(C5=C(F)C=C(Cl)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C30H28ClF2N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-EIJ2D7 WO2025056073A1_D22 . CN1C2=C(C=CC=C2OCC2=CC=C(CN3CCOCC3)C=C2)C(=O)N1C1CCC(=O)NC1=O Degrader C25H28N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-93L5UZ WO2025056073A1_D23 . CCN1C2=C(C=CC=C2OCC2=CC=C(CN3CCOCC3)C=C2)C(=O)N1C1CCC(=O)NC1=O Degrader C26H30N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-PIK6IT SCHEMBL31534744 4-[4-[[4-[[2-(2,6-Dioxopiperidin-3-yl)-1-methyl-3-oxoindazol-7-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile CN1C2=C(C=CC=C2OCC2=CC=C(CN3CCN(C4=C(F)C=C(C#N)C=C4)CC3)C=C2)C(=O)N1C1CCC(=O)NC1=O Degrader C32H31FN6O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-CGQSK1 WO2025056073A1_D25 . CCN1C2=C(C=CC=C2OCC2=CC=C(CN3CCN(C4=C(F)C=C(C#N)C=C4)CC3)C=C2)C(=O)N1C1CCC(=O)NC1=O Degrader C33H33FN6O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-5Z7KUT SCHEMBL31534757 (3S)-3-[3-oxo-7-[[2-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-5-yl]methoxy]-1H-indazol-2-yl]piperidine-2,6-dione O=C1CC[C@H](N2NC3=C(OCC4=CN=C(C5=CC=C(OC(F)(F)F)C=C5)O4)C=CC=C3C2=O)C(=O)N1 Degrader C23H17F3N4O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-D96VDK WO2025056073A1_D27 . O=C1CCC(N2NC3=C(OCC4=CN=C(C5=CC=C(Cl)C=C5)O4)C=CC=C3C2=O)C(=O)N1 Degrader C22H17ClN4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-UT5E5Q SCHEMBL31529395 3-[7-[[2-(4-methoxyphenyl)-1,3-oxazol-5-yl]methoxy]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione COC1=CC=C(C2=NC=C(COC3=C4NN(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)O2)C=C1 Degrader C23H20N4O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-668G5I SCHEMBL31534760 N-[(4-chlorophenyl)methyl]-2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-indazole-6-carboxamide O=C1CCC(N2NC3=C(/C=C\C(C(=O)NCC4=CC=C(Cl)C=C4)=C/3)C2=O)C(=O)N1 Degrader C20H17ClN4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-EJ25SZ SCHEMBL31534778 4-[4-[5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-3-oxo-1H-indazol-7-yl]oxymethyl]pyridin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile N#CC1=CC(F)=C(N2CCC(SC3=CC=C(COC4=CC=CC5=C4NN([C@H]4CCC(=O)NC4=O)C5=O)C=N3)CC2)C=C1 Degrader C30H27FN6O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-IUALFP SCHEMBL31534770 N-[(1S)-1-(4-chlorophenyl)ethyl]-2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-indazole-6-carboxamide C[C@H](NC(=O)C1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)N2)C1=CC=C(Cl)C=C1 Degrader C21H19ClN4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025056073-A1 TPD-SS559Q SCHEMBL31454804 3-[6-(1-benzylpiperidin-4-yl)-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=CC(C4CCN(CC5=CC=CC=C5)CC4)=CC=C3C2=O)C(=O)N1 Degrader C24H26N4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-MCJOY7 SCHEMBL31454801 3-[6-[1-[(3-chlorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC(C4CCN(CC5=CC=CC(Cl)=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H25ClN4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-L8BXZE SCHEMBL31454803 3-[[4-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-indazol-6-yl]piperidin-1-yl]methyl]benzonitrile N#CC1=CC(CN2CCC(C3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)N4)CC2)=CC=C1 Degrader C25H25N5O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-D186SX SCHEMBL31454891 3-[3-oxo-6-[1-[[3-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC(C4CCN(CC5=CC=CC(C(F)(F)F)=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C25H25F3N4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-7LC8W5 SCHEMBL31454823 3-[6-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC(C4CCN(CC5=CC=CC=C5Cl)CC4)=C3)C2=O)C(=O)N1 Degrader C24H25ClN4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-PGP722 WO2025056074A1_z14 . N#CC1=CC=CC=C1CN1CCC(C2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)N3)CC1 Degrader C25H25N5O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-27B3Z3 SCHEMBL31454815 3-[3-oxo-6-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC(C4CCN(CC5=CC=CC=C5C(F)(F)F)CC4)=C3)C2=O)C(=O)N1 Degrader C25H25F3N4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-2KXJOM SCHEMBL31454951 3-[6-[1-[(2,4-difluorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC(C4CCN(CC5=CC=C(F)C=C5F)CC4)=C3)C2=O)C(=O)N1 Degrader C24H24F2N4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-OQRVO5 SCHEMBL31454843 3-[6-[1-[(2,4-dichlorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC(C4CCN(CC5=CC=C(Cl)C=C5Cl)CC4)=C3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-WAQO1Z SCHEMBL31454824 3-[6-[1-[(4-chloro-2-fluorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC(C4CCN(CC5=CC=C(Cl)C=C5F)CC4)=C3)C2=O)C(=O)N1 Degrader C24H24ClFN4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-328IAH SCHEMBL31454866 3-[6-[1-[(2-chloro-4-fluorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-indazol-2-yl]piperidine-2,6-dione O=C1CCC(N2NC3=C(C=CC(C4CCN(CC5=CC=C(F)C=C5Cl)CC4)=C3)C2=O)C(=O)N1 Degrader C24H24ClFN4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-C7VCVX WO2025056074A1_z2 . O=C1CCC(N2NC3C=C(C4CCN(CC5=CC=C(Cl)C=C5)CC4)C=CC3C2=O)C(=O)N1 Degrader C24H27ClN4O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-CVHS4R SCHEMBL31454848 4-[[4-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-indazol-6-yl]piperidin-1-yl]methyl]-3-fluorobenzonitrile N#CC1=CC=C(CN2CCC(C3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)N4)CC2)C(F)=C1 Degrader C25H24FN5O3 IKZF2 Q9UKS7 CRBN WO-2025056074-A1 TPD-E5EP3L MRT-2359 [2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]methyl N-[2-fluoro-5-(trifluoromethoxy)phenyl]carbamate; 2803881-11-8; MRT2359; [2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]methyl N-[2-fluoro-5-(trifluoromethoxy)phenyl]carbamate; M2R4A9NKZ8; orb1741339; SCHEMBL26740495; SCHEMBL30767695; SCHEMBL31438897; GTPL12629; BDBM654045; GLXC-27405; EX-A7775; MRT-2539?; NSC847603; US11912682, Compound 145; NSC-847603; DA-55721; SY361734; TS-09459; HY-153356; CS-0694259; G83026; T-13-00; Z8167331771; (2-Fluoro-5-trifluoromethoxy-phenyl)-carbamic acid 2-(2,6-dioxo-piperidin-3-yl)-3-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl ester; [2-(2,6-Dioxo-3-piperidyl)-3-oxo-5-isoindolinyl]methyl [2-Fluoro-5-(trifluoromethoxy)phenyl]carbamate; Carbamic acid, N-[2-fluoro-5-(trifluoromethoxy)phenyl]-, [2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindol-5-yl]methyl ester O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(OC(F)(F)F)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C22H17F4N3O6 GSPT1 P15170 CRBN WO-2025078667-A1 TPD-4Y42OT SCHEMBL31398140 methyl (3R)-3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoate COC(=O)C[C@@H](C)N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C18H19N3O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-WA3N0Q SCHEMBL31494093 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-(4-fluorophenyl)ethyl]amino]isoindole-1,3-dione C[C@@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=C(F)C=C1 Degrader C21H18FN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-FR10OV SCHEMBL31494094 2-(2,6-dioxopiperidin-3-yl)-4-[[(1S)-1-(4-methoxyphenyl)ethyl]amino]isoindole-1,3-dione COC1=CC=C([C@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C22H21N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-LAO9NU SCHEMBL31489238 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]isoindole-1,3-dione COC1=CC=C([C@@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C22H21N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-Q7H3OL SCHEMBL31494100 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-[4-(trifluoromethoxy)phenyl]ethyl]amino]isoindole-1,3-dione C[C@@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=C(OC(F)(F)F)C=C1 Degrader C22H18F3N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-SKFZHM SCHEMBL31494091 2-(2,6-dioxopiperidin-3-yl)-4-[[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]amino]isoindole-1,3-dione C[C@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=C(OC(F)(F)F)C=C1 Degrader C22H18F3N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-938WI9 SCHEMBL31494103 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-(2-fluorophenyl)ethyl]amino]isoindole-1,3-dione C[C@@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=CC=C1F Degrader C21H18FN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-SU8OI9 SCHEMBL31494077 2-(2,6-dioxopiperidin-3-yl)-4-[[(1S)-1-(2-fluorophenyl)ethyl]amino]isoindole-1,3-dione C[C@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=CC=C1F Degrader C21H18FN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-CSGT5G SCHEMBL31494090 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-(3-methoxyphenyl)ethyl]amino]isoindole-1,3-dione COC1=CC([C@@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=CC=C1 Degrader C22H21N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-CR9POF SCHEMBL31494098 2-(2,6-dioxopiperidin-3-yl)-4-[[(1S)-1-(3-methoxyphenyl)ethyl]amino]isoindole-1,3-dione COC1=CC([C@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=CC=C1 Degrader C22H21N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-NFR4RB SCHEMBL31494065 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-[2-(trifluoromethyl)phenyl]ethyl]amino]isoindole-1,3-dione C[C@@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=CC=C1C(F)(F)F Degrader C22H18F3N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-KHSNSE SCHEMBL31398122 methyl (3S)-3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoate COC(=O)C[C@H](C)N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C18H19N3O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-F5VH0L SCHEMBL31398186 4-[(1R)-1-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]benzenesulfonamide C[C@@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=C(S(N)(=O)=O)C=C1 Degrader C21H20N4O6S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-TRL5BC SCHEMBL31494071 methyl 4-[(1R)-1-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]benzoate COC(=O)C1=CC=C([C@@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C23H21N3O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-4KZIMR SCHEMBL31398136 methyl 4-[(1S)-1-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]benzoate COC(=O)C1=CC=C([C@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C23H21N3O6 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-3444DJ SCHEMBL31494076 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-(4-methylphenyl)ethyl]amino]isoindole-1,3-dione CC1=CC=C([C@@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C22H21N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-1VLXG6 SCHEMBL31494099 2-(2,6-dioxopiperidin-3-yl)-4-[[(1S)-1-(4-methylphenyl)ethyl]amino]isoindole-1,3-dione CC1=CC=C([C@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C22H21N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-XP0L5M SCHEMBL31494080 4-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione C[C@@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=C(Cl)C=C1 Degrader C21H18ClN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-TOG5SM SCHEMBL31494101 4-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione C[C@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=C(Cl)C=C1 Degrader C21H18ClN3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-7SQEQE SCHEMBL31494083 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-(2-fluoro-4-methoxyphenyl)ethyl]amino]isoindole-1,3-dione COC1=CC=C([C@@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(F)=C1 Degrader C22H20FN3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-B2PEGN SCHEMBL31494085 2-(2,6-dioxopiperidin-3-yl)-4-[[(1S)-1-(2-fluoro-4-methoxyphenyl)ethyl]amino]isoindole-1,3-dione COC1=CC=C([C@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(F)=C1 Degrader C22H20FN3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-U61E2O SCHEMBL31494104 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-(4-fluoro-3-methoxyphenyl)ethyl]amino]isoindole-1,3-dione COC1=CC([C@@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=CC=C1F Degrader C22H20FN3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-CJ4AJA SCHEMBL31398166 2-(2,6-dioxopiperidin-3-yl)-4-[[(2S)-1-hydroxypropan-2-yl]amino]isoindole-1,3-dione C[C@@H](CO)N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C16H17N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-789H9Z SCHEMBL31494089 2-(2,6-dioxopiperidin-3-yl)-4-[[(1S)-1-(4-fluoro-3-methoxyphenyl)ethyl]amino]isoindole-1,3-dione COC1=CC([C@H](C)N/C2=C/C=C\C3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=CC=C1F Degrader C22H20FN3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-J705UK SCHEMBL31494092 2-(2,6-dioxopiperidin-3-yl)-4-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]isoindole-1,3-dione C[C@@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=C(C(F)(F)F)C=C1 Degrader C22H18F3N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-WVOYRC SCHEMBL31494067 2-(2,6-dioxopiperidin-3-yl)-4-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]isoindole-1,3-dione C[C@H](N/C1=C/C=C\C2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC=C(C(F)(F)F)C=C1 Degrader C22H18F3N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2025084740-A1 TPD-HE0IMC WO2025092775A1_1 . O=C1CCC(N2/N=C\C3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC=C5)OC4)=C3)C2=O)C(=O)N1 Degrader C24H20N4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-XENSX2 WO2025092775A1_10 . O=C1CCC(N2/N=C\C3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC(OC(F)(F)F)=C5)OC4)=C3)C2=O)C(=O)N1 Degrader C25H19F3N4O6 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-1W9LX2 WO2025092775A1_11 . C/C1=C/C=C\C2=C1OCC(C(=O)NCC1=C/C3=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)N=C3)=C2 Degrader C25H22N4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-AA32EZ WO2025092775A1_12 . CC1=CC2=C(C=C1)OC/C(C(=O)NCC1=CC3=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)/N=C\3)=C\2 Degrader C25H22N4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-H8D9GV WO2025092775A1_13 . O=C1CCC(N2/N=C\C3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC(Cl)=C5)OC4)=C3)C2=O)C(=O)N1 Degrader C24H19ClN4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-W2MKT5 WO2025092775A1_14 . O=C1CCC(N2/N=C\C3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC(Br)=C5)OC4)=C3)C2=O)C(=O)N1 Degrader C24H19BrN4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-DIG6PE WO2025092775A1_15 . O=C1CCC(N2/N=C\C3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC=C5C(F)(F)F)OC4)=C3)C2=O)C(=O)N1 Degrader C25H19F3N4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-17YMDA WO2025092775A1_16 . C=CC1=CC2=C(C=C1)OC/C(C(=O)NCC1=CC3=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)/N=C\3)=C\2 Degrader C26H22N4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-C1EYH4 WO2025092775A1_17 . CC(C)(C)C1=CC2=C(C=C1)OC/C(C(=O)NCC1=CC3=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)/N=C\3)=C\2 Degrader C28H28N4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-HFHTH5 WO2025092775A1_18 . O=C1CCC(N2/N=C\C3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC(C6=CC=CC=C6)=C5)OC4)=C3)C2=O)C(=O)N1 Degrader C30H24N4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-X5ULT9 WO2025092775A1_19 . O=C1CCC(N2/N=C\C3=C(C=CC(CNC(=O)/C4=C/C5=C(OC4)C(F)=CC(F)=C5)=C3)C2=O)C(=O)N1 Degrader C24H18F2N4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-RYN1BM WO2025092775A1_2 . O=C1CCC(N2/N=C\C3=C(C=CC(CNC(=O)/C4=C/C5=C(C=CC=C5F)OC4)=C3)C2=O)C(=O)N1 Degrader C24H19FN4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-XKE47V WO2025092775A1_20 . CC1=CC2=C(C=C1Cl)/C=C(/C(=O)NCC1=CC3=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)/N=C\3)CO2 Degrader C25H21ClN4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-6WBD0N WO2025092775A1_21 . O=C1CCC(N2/N=C\C3=C(C=CC(CNC(=O)C4COC5=C(C=CC=C5)C4)=C3)C2=O)C(=O)N1 Degrader C24H22N4O5 GSPT1 P15170 CRBN WO-2025092775-A1 TPD-P1YJFI SCHEMBL31638743 N-[[1-(benzenesulfonyl)piperidin-4-yl]methyl]-2-chloroacetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=CC=C2)CC1 Stabilizer C14H19ClN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-YJYX33 SCHEMBL31638707 2-chloro-N-[[1-(4-fluorophenyl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=C(F)C=C2)CC1 Stabilizer C14H18ClFN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-REZBFS SCHEMBL25442348 2-chloro-N-[[1-(4-chlorophenyl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=C(Cl)C=C2)CC1 Stabilizer C14H18Cl2N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-YKYBN7 SCHEMBL31638401 2-chloro-N-[3-[1-(4-chlorophenyl)sulfonylpiperidin-4-yl]propyl]acetamide O=C(CCl)NCCCC1CCN(S(=O)(=O)C2=CC=C(Cl)C=C2)CC1 Stabilizer C16H22Cl2N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-PTD1PY SCHEMBL31638576 2-chloro-N-[[1-(6-chloropyridin-3-yl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=C(Cl)N=C2)CC1 Stabilizer C13H17Cl2N3O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-2HLG07 SCHEMBL31638657 2-chloro-N-[[1-(2-fluorophenyl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=C(F)C=CC=C2)CC1 Stabilizer C14H18ClFN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-IKRBP0 SCHEMBL31638690 2-chloro-N-[[1-(3-fluorophenyl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC(F)=CC=C2)CC1 Stabilizer C14H18ClFN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-5X74V4 SCHEMBL31638623 2-chloro-N-[[1-[3-(trifluoromethyl)phenyl]sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC(C(F)(F)F)=CC=C2)CC1 Stabilizer C15H18ClF3N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-NVUT99 SCHEMBL31638508 2-chloro-N-[[1-[4-(trifluoromethyl)phenyl]sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=C(C(F)(F)F)C=C2)CC1 Stabilizer C15H18ClF3N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-OF9A5N SCHEMBL31638423 2-chloro-N-[[1-[4-(trifluoromethoxy)phenyl]sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=C(OC(F)(F)F)C=C2)CC1 Stabilizer C15H18ClF3N2O4S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-II2AH5 SCHEMBL31638543 2-chloro-N-[[1-(4-cyanophenyl)sulfonylpiperidin-4-yl]methyl]acetamide N#CC1=CC=C(S(=O)(=O)N2CCC(CNC(=O)CCl)CC2)C=C1 Stabilizer C15H18ClN3O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-612ANS WO2025136944A1_21 . O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=C(CO)C=C2)CC1 Stabilizer C15H21ClN2O4S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-TZWGKF SCHEMBL31638557 N-[[1-(4-bromophenyl)sulfonylpiperidin-4-yl]methyl]-2-chloroacetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=C(Br)C=C2)CC1 Stabilizer C14H18BrClN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-A5WBZ0 SCHEMBL31638520 2-chloro-N-[[1-(4-iodophenyl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=C(I)C=C2)CC1 Stabilizer C14H18ClIN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-YSBESF SCHEMBL31638406 2-chloro-N-[[1-(4-methylphenyl)sulfonylpiperidin-4-yl]methyl]acetamide CC1=CC=C(S(=O)(=O)N2CCC(CNC(=O)CCl)CC2)C=C1 Stabilizer C15H21ClN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-BF1DMI SCHEMBL31638626 2-chloro-N-[[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]methyl]acetamide COC1=CC=C(S(=O)(=O)N2CCC(CNC(=O)CCl)CC2)C=C1 Stabilizer C15H21ClN2O4S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-OV1X0T SCHEMBL31638512 N-[[1-(1,3-benzodioxol-5-ylsulfonyl)piperidin-4-yl]methyl]-2-chloroacetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC=C3OCOC3=C2)CC1 Stabilizer C15H19ClN2O5S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-3ZQEZ7 SCHEMBL31638528 2-chloro-N-[[1-(2,4-difluorophenyl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=C(F)C=C(F)C=C2)CC1 Stabilizer C14H17ClF2N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-ZCK3QF WO2025136944A1_28 . O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC(F)=C(F)C=C2)CC1 Stabilizer C14H17ClF2N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-83I8O7 SCHEMBL31638589 2-chloro-N-[[1-(4-chloro-3-fluorophenyl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC(F)=C(Cl)C=C2)CC1 Stabilizer C14H17Cl2FN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-6D1SPC SCHEMBL31638649 2-chloro-N-[[1-(3-chloro-4-fluorophenyl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC(Cl)=C(F)C=C2)CC1 Stabilizer C14H17Cl2FN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-PKY5RD SCHEMBL31638420 2-chloro-N-[[1-[4-chloro-3-(trifluoromethyl)phenyl]sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC(C(F)(F)F)=C(Cl)C=C2)CC1 Stabilizer C15H17Cl2F3N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-C51LGL SCHEMBL31638505 2-chloro-N-[[1-[3-fluoro-4-(trifluoromethyl)phenyl]sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=CC(F)=C(C(F)(F)F)C=C2)CC1 Stabilizer C15H17ClF4N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-TTI4R2 SCHEMBL31638704 2-chloro-N-[[1-(3-fluoro-4-methoxyphenyl)sulfonylpiperidin-4-yl]methyl]acetamide COC1=C(F)C=C(S(=O)(=O)N2CCC(CNC(=O)CCl)CC2)C=C1 Stabilizer C15H20ClFN2O4S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-GCCUWS SCHEMBL31638258 2-chloro-N-[[1-(2,2-difluorospiro[2.5]octan-6-yl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2CCC3(CC2)CC3(F)F)CC1 Stabilizer C16H25ClF2N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-JZO4QN SCHEMBL31638350 2-chloro-N-[[1-(2,2-difluorospiro[3.3]heptan-6-yl)sulfonylpiperidin-4-yl]methyl]acetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2CC3(C2)CC(F)(F)C3)CC1 Stabilizer C15H23ClF2N2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-QHPAMW SCHEMBL31638572 N-[[1-(4-bromo-2-fluorophenyl)sulfonylpiperidin-4-yl]methyl]-2-chloroacetamide O=C(CCl)NCC1CCN(S(=O)(=O)C2=C(F)C=C(Br)C=C2)CC1 Stabilizer C14H17BrClFN2O3S ARAF;BRAF;CRAF;14-3-3σ P10398/P15056/P04049/P31947 . WO-2025136944-A1 TPD-9KKPOB CN118812512A_1 . O=C1CCC(N2CC3=C\C(C4CN(C(=S)NC5=C(F)C=CC(OC(F)(F)F)=C5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C24H20F4N4O4S GSPT1 P15170 CRBN CN-118812512-A TPD-ES6X6S CN118812512A_10 . O=C1CCC(N2CC3=CC(C4CN(C(=S)NC5=CC=CC(OC(F)(F)F)=C5)C4)=CC=C3C2=O)C(=O)N1 Degrader C24H21F3N4O4S GSPT1 P15170 CRBN CN-118812512-A TPD-ONPEXT CN118812512A_11 . O=C1CCC(N2CC3=CC(C4CN(C(=S)NC5=C(F)C=CC(OC(F)(F)F)=C5)C4)=NC=C3C2=O)C(=O)N1 Degrader C23H19F4N5O4S GSPT1 P15170 CRBN CN-118812512-A TPD-NBZYV8 CN118812512A_12 . O=C1CCC(N2CC3=N\C(C4CN(C(=S)NC5=C(F)C=CC(OC(F)(F)F)=C5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C23H19F4N5O4S GSPT1 P15170 CRBN CN-118812512-A TPD-X1MV3P CN118812512A_13 . O=C1CCC(N2CC3=C\C(C4CN(C(=S)NC5=C(F)C=CC(OC(F)(F)F)=C5)C4)=C/N=C\3C2=O)C(=O)N1 Degrader C23H19F4N5O4S GSPT1 P15170 CRBN CN-118812512-A TPD-EZLVXI CN118812512A_14 . O=C1CCC(N2CC3=C\C(C4CN(C(=S)NC5=C(F)C=CC(C(F)(F)F)=C5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C24H20F4N4O3S GSPT1 P15170 CRBN CN-118812512-A TPD-CKT29B CN118812512A_15 . N#CC1=CC=C(F)C(NC(=S)N2CC(C3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)C2)=C1 Degrader C24H20FN5O3S GSPT1 P15170 CRBN CN-118812512-A TPD-0J9V4M CN118812512A_16 . N#CC1=C(Cl)C=C(NC(=S)N2CC(C3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)C2)C(F)=C1 Degrader C24H19ClFN5O3S GSPT1 P15170 CRBN CN-118812512-A TPD-TJZ66I CN118812512A_17 . O=C1CCC(N2CC3=C\C(C4CN(C(=S)NC5=C(F)C=CC(Br)=C5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C23H20BrFN4O3S GSPT1 P15170 CRBN CN-118812512-A TPD-E7JZB3 CN118812512A_18 . O=C1CCC(N2CC3=C\C(C4(F)CN(C(=S)NC5=C(F)C=CC(OC(F)(F)F)=C5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C24H19F5N4O4S GSPT1 P15170 CRBN CN-118812512-A TPD-303NAP CN118812512A_19 . O=C1CCC(N2CC3=C\C(C4CCN(C(=S)NC5=C(F)C=CC(OC(F)(F)F)=C5)CC4)=C/C=C\3C2=O)C(=O)N1 Degrader C26H24F4N4O4S GSPT1 P15170 CRBN CN-118812512-A TPD-IUKU39 CN118812512A_2 . O=C1CCC(N2CC3=C/C=C(C4CN(C(=S)NC5=C(F)C=CC(OC(F)(F)F)=C5)C4)\C=C\3C2=O)C(=O)N1 Degrader C24H20F4N4O4S GSPT1 P15170 CRBN CN-118812512-A TPD-QGC06B CN118812512A_20 . O=C1CCC(N2CC3=C\C(C4CN(C(=S)NC5=C(F)C=C(F)C(Cl)=C5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C23H19ClF2N4O3S GSPT1 P15170 CRBN CN-118812512-A TPD-1NUH9M CN118812512A_21 . O=C1CCC(N2CC3=C\C(C4CN(C(=S)NC5=C(F)C=CC(I)=C5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C23H20FIN4O3S GSPT1 P15170 CRBN CN-118812512-A TPD-XR1S6V CN118812512A_22 . O=C1CCC(N2CC3=C\C(N4CCN(C(=S)NC5=C(F)C=CC(OC(F)(F)F)=C5)CC4)=C/C=C\3C2=O)C(=O)N1 Degrader C25H23F4N5O4S GSPT1 P15170 CRBN CN-118812512-A TPD-JHXRQ9 SCHEMBL31306519 5-[3-[[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]methyl]azetidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CC3CN(C4=C/C5=C(\C=C/4F)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)=C1 Degrader C27H28FN7O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-SJ3VL9 SCHEMBL31306481 5-[3-[[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]methyl]pyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione NC1=CC(N2CCN(CC3CCN(C4=CC5=C(C=C4F)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)=CC=C1[N+](=O)[O-] Degrader C28H30FN7O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-OU9NBT 3059333-98-8 5-[4-[[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]methyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione; SZU-B6; orb2695624; SCHEMBL31306505; EX-A13249 NC1=C([N+](=O)[O-])C=CC(N2CCN(CC3CCN(C4=C/C5=C(\C=C/4F)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=C1 Degrader C29H32FN7O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-N5IWUB CN119019370A_10d 5-[3-[[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]methyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CC3CCCN(C4=C/C5=C(\C=C/4F)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)=C1 Degrader C29H32FN7O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-Y0KW1C SCHEMBL31306493 5-[4-[2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CCC3CCN(C4=C/C5=C(\C=C/4F)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=C1 Degrader C30H34FN7O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-UR6RAN SCHEMBL31306527 5-[4-[3-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]propyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CCCC3CCN(C4=C/C5=C(\C=C/4F)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=C1 Degrader C31H36FN7O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-RQRTG3 SCHEMBL31306495 5-[6-[[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CC3C4CN(C5=C/C6=C(\C=C/5F)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC34)CC2)=C1 Degrader C29H30FN7O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-SKKYH3 SCHEMBL31306472 5-[4-[[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]methyl]-4-fluoropiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CC3(F)CCN(C4=C/C5=C(\C=C/4F)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=C1 Degrader C29H31F2N7O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-Q74KHE CN119019370A_10i . NC1=C(NOO)C=CC(N2CCN(CC3CCN(C4CCN(C5=C/C6=C(\C=C/5F)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)CC2)=C1 Degrader C34H43FN8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-LU51P1 SCHEMBL31306502 5-[3-[4-[[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]methyl]piperidin-1-yl]azetidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CC3CCN(C4CN(C5=CC6=C(C=C5F)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)CC3)CC2)=C1 Degrader C32H37FN8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-SEWDI4 CN119019370A_10k . NC1=C([N+](=O)[O-])C=CC(N2CCN(CC3CCN(CC4CCN(C5=C/C6=C(\C=C/5F)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)CC2)=C1 Degrader C35H43FN8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-BMHCQ9 CN119019370A_10l . NC1=C([N+](=O)[O-])C=CC(N2CCN(CC3CN(CC4CCN(C5=C/C6=C(\C=C/5F)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C3)CC2)=C1 Degrader C33H39FN8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-Y6KE6M SCHEMBL31306468 5-[4-[[4-[[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]methyl]piperidin-1-yl]methyl]-4-fluoropiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CC3CCN(CC4(F)CCN(C5=C/C6=C(\C=C/5F)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)CC2)=C1 Degrader C35H42F2N8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-ZI50FJ SCHEMBL31306511 5-[3-[[2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethylamino]methyl]azetidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CCNCC3CN(C4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)=C1 Degrader C29H34N8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-6UO6DG CN119019370A_12b . NC1=C([N+](=O)[O-])C=CC(N2CCN(CCNCC3CCN(C4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)=C1 Degrader C30H36N8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-1CX2JH SCHEMBL31306531 5-[4-[[2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethylamino]methyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CCNCC3CCN(C4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=C1 Degrader C31H38N8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-I6CH1L CN119019370A_12d . NC1=C([N+](=O)[O-])C=CC(N2CCN(CCNCC3CCCN(C4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)=C1 Degrader C31H38N8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-T4OZ3A SCHEMBL31306510 5-[4-[2-[2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethylamino]ethyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CCNCCC3CCN(C4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=C1 Degrader C32H40N8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-NMPGMF CN119019370A_12f . NC1=C([N+](=O)[O-])C=CC(N2CCN(CCNCCCC3CCN(C4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=C1 Degrader C33H42N8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-KSKMPO SCHEMBL31306467 5-[6-[[2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethylamino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione NC1=C([N+](=O)[O-])C=CC(N2CCN(CCNCC3C4CN(C5=C/C6=C(\C=C/5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC34)CC2)=C1 Degrader C31H36N8O6 SIRT6;GSPT1 Q8N6T7/P15170 CRBN CN-119019370-A TPD-AWMPZP SCHEMBL20702905 US11427553, Example 1; SCHEMBL29842856; IAOAVCNNXDYQHL-UHFFFAOYSA-N; US11427553, Example 1; BDBM568562; 5-[4-(4,4-Difluoropiperidin-1-yl)-3-fluorophenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(4,4-Difluoropiperidin-1-yl)-3-fluorophenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC=C(N3CCC(F)(F)CC3)C(F)=C2)CO1 Stabilizer C14H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-3TRGF4 SCHEMBL20702879 US11427553, Example 10; SCHEMBL29842353; BDBM568570; US11427553, Example 10; 5-[4-(3,6-Dihydro-2H-pyran-4-yl)-3-methylphenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=C(C2=CCOCC2)C=CC(C2=NNC(=O)OC2)=C1 Stabilizer C15H16N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-YOSWL3 SCHEMBL20703158 US11427553, Example 100; SCHEMBL30580703; BDBM568648; US11427553, Example 100; 5-(2,2',5'-Trifluoro[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=CC(F)=CC=C3F)C=C2)CO1 Stabilizer C15H9F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-4SPA5D SCHEMBL20703232 US11427553, Example 101; BDBM568649; US11427553, Example 101; 2'-Fluoro-4'-(2-oxo-3,6-dihydro-2H-1,3,4-oxadiazin-5-yl)[1,1'-biphenyl]-4-carbonitrile N#CC1=CC=C(C2=C(F)C=C(C3=NNC(=O)OC3)C=C2)C=C1 Stabilizer C16H10FN3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-VRS0AQ WO2019025562-A1_102 . NC1CC=CC=C1C1=C(F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H14FN3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-4GUVPG SCHEMBL20702611 US11427553, Example 103; SCHEMBL30580686; BDBM568651; US11427553, Example 103; 5-(3'-Amino-2-fluoro-4'-methyl[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=CC=C(C2=C(F)C=C(C3=NNC(=O)OC3)C=C2)C=C1N Stabilizer C16H14FN3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-FKXGQ8 SCHEMBL20705296 US11427553, Example 104; BDBM568838; US11427553, Example 104; 5-(2-Fluoro-3'-hydroxy[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=CC=CC(O)=C3)C=C2)CO1 Stabilizer C15H11FN2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-2DJGT1 SCHEMBL20702627 US11427553, Example 105; SCHEMBL30580625; BDBM568652; US11427553, Example 105; 5-(2-Fluoro-4'-hydroxy[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=CC=C(O)C=C3)C=C2)CO1 Stabilizer C15H11FN2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-1GVCLR SCHEMBL20702635 US11427553, Example 106; SCHEMBL30580684; BDBM568653; US11427553, Example 106; 5-(2-Fluoro-2'-hydroxy[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=CC=CC=C3O)C=C2)CO1 Stabilizer C15H11FN2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-PG55U9 SCHEMBL20702656 US11427553, Example 107; BDBM568654; US11427553, Example 107; 5-(2,3',4'-Trifluoro[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=CC=C(F)C(F)=C3)C=C2)CO1 Stabilizer C15H9F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-EI0ZIL SCHEMBL20702610 US11427553, Example 108; BDBM568655; US11427553, Example 108; 5-[3-Fluoro-4-(pyridin-3-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=CN=CC=C3)C=C2)CO1 Stabilizer C14H10FN3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-VZMKYT SCHEMBL20703306 US11427553, Example 109; BDBM568656; US11427553, Example 109; 5-(2,2',3'-Trifluoro[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=C(F)C(F)=CC=C3)C=C2)CO1 Stabilizer C15H9F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-2L65YG SCHEMBL20702907 US11427553, Example 11; SCHEMBL30692567; BDBM568571; US11427553, Example 11; 5-[3-Methyl-4-(1H-pyrazol-4-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=C(C2=CNN=C2)C=CC(C2=NNC(=O)OC2)=C1 Stabilizer C13H12N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-2RY6JP SCHEMBL20702914 US11427553, Example 110; SCHEMBL30580708; BDBM568657; US11427553, Example 110; 5-(2,3',5'-Trifluoro[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=CC(F)=CC(F)=C3)C=C2)CO1 Stabilizer C15H9F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-62XQL7 SCHEMBL20702975 US11427553, Example 111; BDBM568658; US11427553, Example 111; 5-(2,2',4'-Trifluoro[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=C(F)C=C(F)C=C3)C=C2)CO1 Stabilizer C15H9F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-J24DD2 SCHEMBL20702612 US11427553, Example 112; BDBM568659; US11427553, Example 112; 5-(2-Fluoro-2',4'-dimethyl[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=CC(C)=C(C2=C(F)C=C(C3=NNC(=O)OC3)C=C2)C=C1 Stabilizer C17H15FN2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-4BQLBM SCHEMBL20702714 US11427553, Example 113; BDBM568660; US11427553, Example 113; 5-(2,3'-Difluoro-4'-methyl[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=C(F)C=C(C2=C(F)C=C(C3=NNC(=O)OC3)C=C2)C=C1 Stabilizer C16H12F2N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-QR1QIH SCHEMBL20702890 US11427553, Example 114; BDBM568661; US11427553, Example 114; 5-(2,2'-Difluoro[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=C(F)C=CC=C3)C=C2)CO1 Stabilizer C15H10F2N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-MKGNH2 SCHEMBL20702637 US11427553, Example 115; BDBM568662; US11427553, Example 115; 5-(2,2',6'-Trifluoro[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=C(F)C=CC=C3F)C=C2)CO1 Stabilizer C15H9F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-NH432C SCHEMBL20702763 US11427553, Example 116; BDBM568663; US11427553, Example 116; 5-(2-Fluoro-2'-methoxy[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one COC1=C(C2=C(F)C=C(C3=NNC(=O)OC3)C=C2)C=CC=C1 Stabilizer C16H13FN2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-ZKZY32 SCHEMBL20703237 US11427553, Example 117; BDBM568664; US11427553, Example 117; 5-(2,3'-Difluoro[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=CC(F)=CC=C3)C=C2)CO1 Stabilizer C15H10F2N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-3FX0LB SCHEMBL20703161 US11427553, Example 118; BDBM568665; US11427553, Example 118; 5-[3-Fluoro-4-(4-methylpyridin-3-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=C(C2=C(F)C=C(C3=NNC(=O)OC3)C=C2)C=NC=C1 Stabilizer C15H12FN3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-KEJNPE SCHEMBL20702904 US11427553, Example 119; BDBM568666; US11427553, Example 119; (rac)-5-(3-Fluoro-4-morpholinophenyl)-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1OC(=O)NN=C1C1=CC=C(N2CCOCC2)C(F)=C1 Stabilizer C14H16FN3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-BL9D46 SCHEMBL20702634 5-[3-methyl-4-(6-oxo-1H-pyridin-3-yl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one CC1=C(C2=CNC(=O)C=C2)C=CC(C2=NNC(=O)OC2)=C1 Stabilizer C15H13N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-9KTNPT SCHEMBL20702583 (6S)-6-methyl-5-[4-morpholin-4-yl-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; SCHEMBL29842732; VPFVSVYEZRQCSG-VIFPVBQESA-N; (6S)-6-methyl-5-[4-morpholin-4-yl-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(N2CCOCC2)C(C(F)(F)F)=C1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-EEG1SI SCHEMBL20716745 US11427553, Example 121; SCHEMBL29842377; MILHWNGXHGLLTF-QMMMGPOBSA-N; BDBM568668; US11427553, Example 121; (6S)-5-(-[(3-Chloro-4-(morpholin-4-yl)-5-(trifluoromethyl)phenyl)-)]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[3-chloro-4-morpholin-4-yl-5-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC(Cl)=C(N2CCOCC2)C(C(F)(F)F)=C1 Stabilizer C15H15ClF3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-P4BT36 SCHEMBL20702876 US11427553, Example 126; VPFVSVYEZRQCSG-UHFFFAOYSA-N; BDBM568669; US11427553, Example 126; (rac)-6-Methyl-5-(4-morpholino-3-(trifluoromethyl)phenyl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 6-Methyl-5-[4-morpholin-4-yl-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one CC1OC(=O)NN=C1C1=CC=C(N2CCOCC2)C(C(F)(F)F)=C1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-44ZMYA SCHEMBL20702854 US11427553, Example 127; NNYVUXWGZYBGSC-UHFFFAOYSA-N; BDBM568839; US11427553, Example 127; 5-[4-[1-Methyl-3-(trifluoromethyl)pyrazol-4-yl]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CN1C=C(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)C(C(F)(F)F)=N1 Stabilizer C15H10F6N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-OLT12Y SCHEMBL20702720 5-[4-(3,5-dimethyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; SCHEMBL29842595; IBJVKSNORDBFND-UHFFFAOYSA-N; 5-[4-(3,5-dimethyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one CC1=NNC(C)=C1C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H13F3N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-CUF8MA SCHEMBL20702613 US11427553, Example 129; SCHEMBL29842745; OCOHVUNJBKXDTF-UHFFFAOYSA-N; BDBM568841; US11427553, Example 129; 5-[4-(3,5-Dimethyl-1,2-oxazol-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(3,5-Dimethyl-1,2-oxazol-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=NOC(C)=C1C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H12F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-ACNFLC SCHEMBL20702645 US11427553, Example 13; BDBM568572; US11427553, Example 13; 5-[3-Methyl-4-(pyridin-3-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=C(C2=CC=CN=C2)C=CC(C2=NNC(=O)OC2)=C1 Stabilizer C15H13N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-HAT6B5 SCHEMBL20702827 5-[3-(trifluoromethyl)-4-[5-(trifluoromethyl)-1H-pyrazol-4-yl]phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; SCHEMBL29842605; KSUZWMWMORSGOH-UHFFFAOYSA-N; 5-[3-(trifluoromethyl)-4-[5-(trifluoromethyl)-1H-pyrazol-4-yl]phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CNN=C3C(F)(F)F)C=C2)CO1 Stabilizer C14H8F6N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-UL82OC SCHEMBL20702943 US11427553, Example 131; LKVAXYUHJKCXRX-UHFFFAOYSA-N; BDBM568670; US11427553, Example 131; 5-[4-(1-Ethylpyrazol-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(1-Ethyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CCN1C=C(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)C=N1 Stabilizer C15H13F3N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-NPS9IT SCHEMBL20702915 US11427553, Example 132; SCHEMBL29842966; KNFYAEPYLBLULE-UHFFFAOYSA-N; BDBM568671; US11427553, Example 132; 5-[4-[Cyclopentyl(methyl)amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[Cyclopentyl(methyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CN(C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1)C1CCCC1 Stabilizer C16H18F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-RNA6C5 SCHEMBL20702700 US11427553, Example 133; SCHEMBL29842635; LFVIOVSORBCSRB-UHFFFAOYSA-N; BDBM568672; US11427553, Example 133; 5-[4-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one CN1CC=C(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)CC1 Stabilizer C16H16F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-Q3V1P9 SCHEMBL20703049 US11427553, Example 134; SCHEMBL29842705; XCLWOENOEKDGQK-UHFFFAOYSA-N; BDBM568673; US11427553, Example 134; 5-[4-[Butyl(methyl)amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[Butyl(methyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CCCCN(C)C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H18F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-6WVD8O SCHEMBL20702665 US11427553, Example 136; SCHEMBL29842712; NTTOFFAKCDYQOO-UHFFFAOYSA-N; BDBM568675; US11427553, Example 136; 5-[4-(Cyclopentylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(Cyclopentylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NC3CCCC3)C=C2)CO1 Stabilizer C15H16F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-ZZS6EK SCHEMBL20703041 US11427553, Example 137; YORIIIRVDMNKSJ-UHFFFAOYSA-N; BDBM568676; US11427553, Example 137; 5-[4-(Propan-2-ylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(Propan-2-ylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC(C)NC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C13H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-C92GQP SCHEMBL20702954 US11427553, Example 138; SCHEMBL30692569; WUBSOAMGZUHXEK-UHFFFAOYSA-N; BDBM568677; US11427553, Example 138; 5-[3'-Fluoro-2-(trifluoromethyl)biphenyl-4-yl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-(3-Fluorophenyl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CC=CC(F)=C3)C=C2)CO1 Stabilizer C16H10F4N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-VHOCH9 SCHEMBL20702731 US11427553, Example 139; SCHEMBL30692590; DEZBCGCLCOIZBU-UHFFFAOYSA-N; BDBM568678; US11427553, Example 139; 5-[4-Methyl-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-Methyl-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C11H9F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-YXAB18 SCHEMBL20702940 US11427553, Example 14; BDBM568829; US11427553, Example 14; 5-[3-Methyl-4-(pyrimidin-5-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=C(C2=CN=CN=C2)C=CC(C2=NNC(=O)OC2)=C1 Stabilizer C14H12N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-IT8C4Y SCHEMBL20702703 US11427553, Example 140; RYLLWGXEJSHWDG-NSCUHMNNSA-N; BDBM568679; US11427553, Example 140; 5-[4-[(E)-3-methoxyprop-1-enyl]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[3-Methoxyprop-1-en-1-yl]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one COC/C=C/C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H13F3N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-KKQGG9 SCHEMBL20702967 US11427553, Example 141; WKQXYWSYWAQGFJ-UHFFFAOYSA-N; BDBM568680; US11427553, Example 141; (rac)-5-[4'-Hydroxy-2-(trifluoromethyl)-2',3',4',5'-tetrahydro[1,1'-biphenyl]-4-yl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-(4-Hydroxycyclohexen-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CCC(O)CC3)C=C2)CO1 Stabilizer C16H15F3N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-E8BPBV SCHEMBL20702830 US11427553, Example 142; SCHEMBL29842818; SUWNWKUDIYFSTN-UHFFFAOYSA-N; BDBM568681; US11427553, Example 142; 5-[4-(3,6-dihydro-2H-pyran-5-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(5,6-Dihydro-2H-pyran-3-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CCCOC3)C=C2)CO1 Stabilizer C15H13F3N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-P32AHT SCHEMBL20705292 US11427553, Example 143; SCHEMBL29842545; ZOARZGZEVRPIHO-UHFFFAOYSA-N; BDBM568682; US11427553, Example 143; 5-[4-(Imidazo[1,2-a]pyridin-6-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-Imidazo[1,2-a]pyridin-6-yl-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CN4C=CN=C4C=C3)C=C2)CO1 Stabilizer C17H11F3N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-RS8AFQ SCHEMBL20702658 US11427553, Example 144; ULROFRBOPSXXEA-VOTSOKGWSA-N; BDBM568683; US11427553, Example 144; 5-[4-[(E)-3,3-dimethylbut-1-enyl]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[3,3-Dimethylbut-1-en-1-yl]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC(C)(C)/C=C/C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C16H17F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-6A0207 SCHEMBL20703030 US11427553, Example 145; BLSQHANBUTYZBK-UHFFFAOYSA-N; BDBM568684; US11427553, Example 145; 5-[3-(Trifluoromethyl)-4-[5-(trifluoromethyl)thiophen-3-yl]phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{3-(Trifluoromethyl)-4-[5-(trifluoromethyl)thiophen-3-yl]phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CSC(C(F)(F)F)=C3)C=C2)CO1 Stabilizer C15H8F6N2O2S PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-XYR6KP SCHEMBL20702945 US11427553, Example 146; ABQOWYKZOMELPA-UHFFFAOYSA-N; BDBM568685; US11427553, Example 146; 5-[4-[1-(Difluoromethyl)pyrazol-4-yl]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[1-(Difluoromethyl)-1H-pyrazol-4-yl]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CN(C(F)F)N=C3)C=C2)CO1 Stabilizer C14H9F5N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-0V0QW0 SCHEMBL20702712 US11427553, Example 147; SCHEMBL30692592; KJYJSTIRHYSKPR-UHFFFAOYSA-N; BDBM568686; US11427553, Example 147; 5-[4-(Prop-1-en-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-Prop-1-en-2-yl-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one C=C(C)C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C13H11F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-492ELL SCHEMBL20705306 US11427553, Example 148; SCHEMBL30692596; DLDDNYHHOKSVRW-UHFFFAOYSA-N; BDBM568687; US11427553, Example 148; 5-[4-(1-Benzothiophen-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(1-Benzothiophen-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(/C3=C/C4=C(C=CC=C4)S3)C=C2)CO1 Stabilizer C18H11F3N2O2S PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-PU2X6J SCHEMBL20702786 US11427553, Example 149; KYCLFGAQDWJRRK-UHFFFAOYSA-N; BDBM568688; US11427553, Example 149; 5-[4-(2,5-Dihydrofuran-3-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(2,5-Dihydrofuran-3-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CCOC3)C=C2)CO1 Stabilizer C14H11F3N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-AQI59K SCHEMBL20702596 US11427553, Example 15; SCHEMBL30692611; BDBM568573; US11427553, Example 15; 5-(3'-Fluoro-2-methylbiphenyl-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=C(C2=CC=CC(F)=C2)C=CC(C2=NNC(=O)OC2)=C1 Stabilizer C16H13FN2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-EIB4CN WO2019025562-A1_150 . O=C1NNC(C2=CC(C(F)(F)F)=C(C3=CCCC3)C=C2)CO1 Stabilizer C15H15F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-DOT6M2 SCHEMBL20703195 US11427553, Example 151; ZSDCPMJORZSDGS-UHFFFAOYSA-N; BDBM568690; US11427553, Example 151; 5-[4-(1-Ethylimidazol-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(1-Ethyl-1H-imidazol-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CCN1C=NC(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)=C1 Stabilizer C15H13F3N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-O40K7D SCHEMBL20702536 US11427553, Example 152; SCHEMBL29842710; HBUNMCPRHXBDCX-UHFFFAOYSA-N; BDBM568691; US11427553, Example 152; 3-Methyl-5-[4-(2-oxo-3,6-dihydro-1,3,4-oxadiazin-5-yl)-2-(trifluoromethyl)phenyl]thiophene-2-carbonitrile; 3-Methyl-5-[4-(2-oxo-3,6-dihydro-2H-1,3,4-oxadiazin-5-yl)-2-(trifluoromethyl)phenyl]thiophene-2-carbonitrile CC1=C(C#N)SC(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)=C1 Stabilizer C16H10F3N3O2S PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-RIQPOI SCHEMBL20702554 US11427553, Example 153; SEOSKAFBLAKFPD-UHFFFAOYSA-N; BDBM568692; US11427553, Example 153; 5-[4-(1-Propan-2-ylpyrazol-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[1-(Propan-2-yl)-1H-pyrazol-4-yl]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC(C)N1C=C(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)C=N1 Stabilizer C16H15F3N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-6VI6BH SCHEMBL20702533 US11427553, Example 154; SCHEMBL29842853; ZYBODMTUKDRWQM-UHFFFAOYSA-N; BDBM568693; US11427553, Example 154; (rac)-5-[4-(Bicyclo[2.2.1]hept-2-en-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-(2-Bicyclo[2.2.1]hept-2-enyl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CC4CCC3C4)C=C2)CO1 Stabilizer C17H15F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-IDALL0 SCHEMBL20703015 US11427553, Example 155; SCHEMBL30580610; FEFXNCRFMIZZHK-UHFFFAOYSA-N; BDBM568694; US11427553, Example 155; 5-[4-(2-Fluorophenyl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[2'-Fluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CC=CC=C3F)C=C2)CO1 Stabilizer C16H10F4N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-HQVILG SCHEMBL20702644 US11427553, Example 156; FFRNPLZIICTENM-UHFFFAOYSA-N; BDBM568695; US11427553, Example 156; 5-[3-(Trifluoromethyl)-4-[5-(trifluoromethyl)thiophen-2-yl]phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{3-(Trifluoromethyl)-4-[5-(trifluoromethyl)thiophen-2-yl]phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CC=C(C(F)(F)F)S3)C=C2)CO1 Stabilizer C15H8F6N2O2S PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-WO8VK4 SCHEMBL20702636 US11427553, Example 157; SCHEMBL29842787; DJMQVJUNBVJEPK-UHFFFAOYSA-N; BDBM568696; US11427553, Example 157; 5-[4-(5-Methylpyridin-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(5-Methylpyridin-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=CN=C(C2=CC=C(C3=NNC(=O)OC3)C=C2C(F)(F)F)C=C1 Stabilizer C16H12F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-9GUWGH SCHEMBL20702654 US11427553, Example 158; SCHEMBL29842602; NWFFCJBUMMVCRX-UHFFFAOYSA-N; BDBM568697; US11427553, Example 158; 5-[4-(5-Fluoropyridin-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(5-Fluoropyridin-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=NC=C(F)C=C3)C=C2)CO1 Stabilizer C15H9F4N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-CJ4VCU SCHEMBL20703172 US11427553, Example 159; SCHEMBL29842877; ZVJWTSJWSMDARQ-UHFFFAOYSA-N; BDBM568698; US11427553, Example 159; 5-[4-(5-Chloropyridin-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(5-Chloropyridin-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=NC=C(Cl)C=C3)C=C2)CO1 Stabilizer C15H9ClF3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-ZCPEYA SCHEMBL20705947 US11427553, Example 160; SCHEMBL30692603; FUQINQITUBUYBR-UHFFFAOYSA-N; BDBM568699; US11427553, Example 160; 5-[4-(Pyridin-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-Pyridin-2-yl-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=NC=CC=C3)C=C2)CO1 Stabilizer C15H10F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-CGCDCS SCHEMBL20705307 US11427553, Example 161; SCHEMBL30692565; LIFTWKZNLFUUPN-UHFFFAOYSA-N; BDBM568700; US11427553, Example 161; 5-[4-[2-(Difluoromethyl)phenyl]-3-fluorophenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[2'-(Difluoromethyl)-2-fluoro[1,1'-biphenyl]-4-yl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(C3=C(C(F)F)C=CC=C3)C=C2)CO1 Stabilizer C16H11F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-J3WO6Z SCHEMBL20702529 US11427553, Example 162; SCHEMBL29842851; BDBM568701; US11427553, Example 162; 5-(2,4'-Difluoro-2'-methyl[1,1'-biphenyl]-4-yl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=C(C2=C(F)C=C(C3=NNC(=O)OC3)C=C2)C=CC(F)=C1 Stabilizer C16H12F2N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-E8F1X2 SCHEMBL20702900 US11427553, Example 163; SCHEMBL29842924; BDBM568702; US11427553, Example 163; 2'-Fluoro-2-methyl-4'-(2-oxo-3,6-dihydro-2H-1,3,4-oxadiazin-5-yl)[1,1'-biphenyl]-4-carbonitrile CC1=C(C2=C(F)C=C(C3=NNC(=O)OC3)C=C2)C=CC(C#N)=C1 Stabilizer C17H12FN3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-JPSEIN SCHEMBL20702988 US11427553, Example 164; QXWCJHGGVHVZFT-UHFFFAOYSA-N; BDBM568703; US11427553, Example 164; 5-[4-(2-Methylprop-1-enyl)-3-(trifluoromethoxy)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(2-Methylprop-1-en-1-yl)-3-(trifluoromethoxy)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC(C)=CC1=C(OC(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H13F3N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-S1MRBK SCHEMBL20702803 US11427553, Example 165; SCHEMBL29842830; XZVRWQQQWLPFRB-QMMMGPOBSA-N; BDBM568704; US11427553, Example 165; (6S)-5-[4-(2-aminopyridin-4-yl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one; (6S)-5-[4-(2-Aminopyridin-4-yl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=CC(N)=NC=C2)C(C(F)(F)F)=C1 Stabilizer C16H13F3N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-8W58EV SCHEMBL20702753 US11427553, Example 166; SCHEMBL29842539; KJJACMBDLFUVJV-VIFPVBQESA-N; BDBM568705; US11427553, Example 166; (6S)-6-Methyl-5-[4-(pyridin-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-6-methyl-5-[4-pyridin-4-yl-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=CC=NC=C2)C(C(F)(F)F)=C1 Stabilizer C16H12F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-36EG9Y SCHEMBL20702912 US11427553, Example 167; SCHEMBL29842769; RDPTWFYHEIZOBA-JTQLQIEISA-N; BDBM568706; US11427553, Example 167; (6S)-6-methyl-5-[4-(6-methylpyridin-3-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; (6S)-6-Methyl-5-[4-(6-methylpyridin-3-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=CC=C(C2=CC=C(C3=NNC(=O)O[C@H]3C)C=C2C(F)(F)F)C=N1 Stabilizer C17H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-7IDODH SCHEMBL20702698 US11427553, Example 168; SCHEMBL29842874; QDOZTHLINUJNET-JTQLQIEISA-N; BDBM568707; US11427553, Example 168; (6S)-5-[2'-Fluoro-4'-methyl-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(2-fluoro-4-methylphenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one CC1=CC(F)=C(C2=CC=C(C3=NNC(=O)O[C@H]3C)C=C2C(F)(F)F)C=C1 Stabilizer C18H14F4N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-ZDPRUN SCHEMBL20705334 US11427553, Example 169; SCHEMBL29842765; UTXFHGXBAUIRLZ-ZETCQYMHSA-N; BDBM568708; US11427553, Example 169; (6S)-6-Methyl-5-[2',4',5'-trifluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-6-methyl-5-[3-(trifluoromethyl)-4-(2,4,5-trifluorophenyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=CC(F)=C(F)C=C2F)C(C(F)(F)F)=C1 Stabilizer C17H10F6N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-TJCKRS SCHEMBL20702715 US11427553, Example 17; BDBM568574; US11427553, Example 17; (rac)-5-[3,5-Difluoro-4-(morpholin-4-yl)phenyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1OC(=O)NN=C1C1=CC(F)=C(N2CCOCC2)C(F)=C1 Stabilizer C14H15F2N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-RAI29I SCHEMBL20702961 US11427553, Example 170; SCHEMBL29842718; KQIHCUMWNXFYMS-ZETCQYMHSA-N; BDBM568709; US11427553, Example 170; (6S)-6-Methyl-5-[2',3',4'-trifluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-6-methyl-5-[3-(trifluoromethyl)-4-(2,3,4-trifluorophenyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=C(F)C(F)=C(F)C=C2)C(C(F)(F)F)=C1 Stabilizer C17H10F6N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-QH0VM3 SCHEMBL20702619 US11427553, Example 171; SCHEMBL30580624; NQRKCVDSWOZJKC-QMMMGPOBSA-N; BDBM568710; US11427553, Example 171; (6S)-5-[2',5'-Difluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(2,5-difluorophenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=C(F)C=CC(F)=C2)C(C(F)(F)F)=C1 Stabilizer C17H11F5N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-WDQ42O WO2019025562-A1_172 . CC1OC(=O)NN=C1C1=CC=C(C2=CC=CC=C2C#N)C(C(F)(F)F)=C1 Stabilizer C18H12F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-FNRZEF SCHEMBL20705309 US11427553, Example 173; CRAFDKUTOHUVLX-JTQLQIEISA-N; BDBM568712; US11427553, Example 173; (6S)-5-[4-(1H-indol-5-yl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one; (6S)-5-[4-(1H-Indol-5-yl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=C/C3=C(\C=C/2)NC=C3)C(C(F)(F)F)=C1 Stabilizer C19H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-8PSS6H SCHEMBL20703035 US11427553, Example 174; SCHEMBL30580658; QLSMQXDPLXXTTO-VIFPVBQESA-N; BDBM568713; US11427553, Example 174; US11427553, Example 188; (6S)-5-[4'-Hydroxy-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(4-hydroxyphenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=CC=C(O)C=C2)C(C(F)(F)F)=C1 Stabilizer C17H13F3N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-JUXS5G SCHEMBL20703349 US11427553, Example 175; SCHEMBL30580595; MHLFBNHKEUUGDT-VIFPVBQESA-N; BDBM568714; US11427553, Example 175; (6S)-5-[3'-Hydroxy-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(3-hydroxyphenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=CC(O)=CC=C2)C(C(F)(F)F)=C1 Stabilizer C17H13F3N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-1RY1D6 SCHEMBL20702861 US11427553, Example 176; SCHEMBL29842693; GIHKNYQIKPLINP-VIFPVBQESA-N; BDBM568715; US11427553, Example 176; (6S)-5-[3'-Amino-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(3-aminophenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=CC=CC(N)=C2)C(C(F)(F)F)=C1 Stabilizer C17H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-D0FS3K SCHEMBL23561763 (3R,4R)-4-[[[3-propan-2-yl-7-[[3-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561763 CC(C)c1cnn2c(NCc3nc4ccccn4c3C(F)(F)F)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C24H29F3N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-15EEGB WO2021122745-A1_H-APPAMP-024 . CC(C)c1cnn2c(NCc3nc4ccccn4c3C3CC3)cc(NC[C@H]3CCNC[C@H]3O)nc12 Degrader C26H34N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-AAUTT3 SCHEMBL20702534 US11427553, Example 177; SCHEMBL30580678; WFZBHBLUCVRJNX-QMMMGPOBSA-N; BDBM568716; US11427553, Example 177; (6S)-5-[2',4'-Difluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(2,4-difluorophenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=C(F)C=C(F)C=C2)C(C(F)(F)F)=C1 Stabilizer C17H11F5N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-BFS0S8 SCHEMBL20702926 US11427553, Example 178; SCHEMBL29842865; KQIQTSQHKHNYJY-JTQLQIEISA-N; BDBM568717; US11427553, Example 178; (6S)-5-[3'-Fluoro-4'-methyl-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(3-fluoro-4-methylphenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one CC1=C(F)C=C(C2=CC=C(C3=NNC(=O)O[C@H]3C)C=C2C(F)(F)F)C=C1 Stabilizer C18H14F4N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-SICYN6 SCHEMBL23561765 (3R,4R)-4-[[[3-cyclopropyl-7-[(5-methylimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561765 Cc1cccc2nc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)cn12 Degrader C24H30N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-ZM1YW0 SCHEMBL23561762 (3R,4R)-4-[[[3-ethyl-7-[(8-methylimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561762 CCc1cnn2c(NCc3cn4cccc(C)c4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C23H30N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-EEW8IS SCHEMBL20702572 US11427553, Example 179; SCHEMBL29842886; GVDRUTSKBXIUEW-VIFPVBQESA-N; BDBM568718; US11427553, Example 179; (6S)-5-[2'-Fluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(2-fluorophenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=C(F)C=CC=C2)C(C(F)(F)F)=C1 Stabilizer C17H12F4N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-MIPSV3 SCHEMBL20705326 US11427553, Example 18; BDBM568575; US11427553, Example 18; 5-{3,5-Difluoro-4-[2-methylmorpholin-4-yl]phenyl}-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one (Mixture of stereoisomers) CC1CN(C2=C(F)C=C(C3=NNC(=O)OC3C)C=C2F)CCO1 Stabilizer C15H17F2N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-UEOILL SCHEMBL23561776 (3R,4R)-4-[[[3-cyclopropyl-7-[(5-methoxyimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561776 COc1cccc2nc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)cn12 Degrader C24H30N8O2 CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-J6RKG6 SCHEMBL23562147 (3R,4R)-4-[[[3-cyclopropyl-7-[(6-cyclopropylimidazo[1,2-b]pyridazin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562147 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2cn3nc(C4CC4)ccc3n2)n2ncc(C3CC3)c2n1 Degrader C25H31N9O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-04LHMB SCHEMBL20702548 US11427553, Example 180; SCHEMBL29842848; HCIDSTUOZLVOEQ-JTQLQIEISA-N; BDBM568719; US11427553, Example 180; (6S)-5-[2'-Methoxy-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(2-methoxyphenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one COC1=CC=CC=C1C1=CC=C(C2=NNC(=O)O[C@H]2C)C=C1C(F)(F)F Stabilizer C18H15F3N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-1QZGJ9 SCHEMBL20702842 US11427553, Example 181; SCHEMBL29842902; GLILTUPAPNTIBB-VIFPVBQESA-N; BDBM568720; US11427553, Example 181; (6S)-5-[3'-Fluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-5-[4-(3-fluorophenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=CC(F)=CC=C2)C(C(F)(F)F)=C1 Stabilizer C17H12F4N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-TPGUUC SCHEMBL23561778 (3R,4R)-4-[[[3-cyclobutyl-7-[(8-methylimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561778 Cc1cccn2cc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CCC5)cnn34)nc12 Degrader C25H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-7RHVGK SCHEMBL20702874 US11427553, Example 182; SCHEMBL29843060; XFINUDQNQVAXQO-JTQLQIEISA-N; BDBM568721; US11427553, Example 182; (6S)-6-methyl-5-[4-(4-methylpyridin-3-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; (6S)-6-Methyl-5-[4-(4-methylpyridin-3-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=CC=NC=C1C1=CC=C(C2=NNC(=O)O[C@H]2C)C=C1C(F)(F)F Stabilizer C17H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-6RW3NO SCHEMBL23561779 (3R,4R)-4-[[[3-cyclopropyl-7-[(5-cyclopropylimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561779 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2cn3c(C4CC4)cccc3n2)n2ncc(C3CC3)c2n1 Degrader C26H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-W7BYV6 SCHEMBL23562043 (3R,4R)-4-[[[3-ethyl-7-[(5-methylimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562043 CCc1cnn2c(NCc3cn4c(C)cccc4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C23H30N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-XES8Z6 SCHEMBL20702866 US11427553, Example 183; SCHEMBL29842741; QAMBZWUEYQFBKA-JTQLQIEISA-N; BDBM568722; US11427553, Example 183; (6S)-6-methyl-5-[4-(3-methylpyridin-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; (6S)-6-Methyl-5-[4-(3-methylpyridin-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=CN=CC=C1C1=CC=C(C2=NNC(=O)O[C@H]2C)C=C1C(F)(F)F Stabilizer C17H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-5ONUSV SCHEMBL20702708 US11427553, Example 184; SCHEMBL29842761; IPEVOPPPDXENKM-JTQLQIEISA-N; BDBM568723; US11427553, Example 184; (6S)-6-methyl-5-[4-(2-methylpyridin-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; (6S)-6-Methyl-5-[4-(2-methylpyridin-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=NC=CC(C2=CC=C(C3=NNC(=O)O[C@H]3C)C=C2C(F)(F)F)=C1 Stabilizer C17H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-P9RNHW SCHEMBL23561783 (3R,4R)-4-[[[3-cyclopropyl-7-[(5,7-dimethylimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561783 Cc1cc(C)n2cc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)nc2c1 Degrader C25H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-1P6IZF SCHEMBL23562040 (3R,4R)-4-[[[7-[[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methylamino]-3-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562040 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2cn3cc(C(F)(F)F)cc(Cl)c3n2)n2ncc(C3CC3)c2n1 Degrader C24H26ClF3N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-ABERKW SCHEMBL20702878 US11427553, Example 185; FVABQEGQFDIRKT-JTQLQIEISA-N; BDBM568724; US11427553, Example 185; (6S)-5-[4-(1H-indol-6-yl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one; (6S)-5-[4-(1H-Indol-6-yl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC=C(C2=C/C3=C(C=CN3)/C=C\2)C(C(F)(F)F)=C1 Stabilizer C19H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-CHDRDD SCHEMBL20702792 (6S)-5-[4-(2-ethylphenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one; SFXKPQNCLUZXJU-NSHDSACASA-N; (6S)-5-[4-(2-ethylphenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one CCC1=C(C2=CC=C(C3=NNC(=O)O[C@H]3C)C=C2C(F)(F)F)C=CC=C1 Stabilizer C19H17F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-BNVOIY SCHEMBL23562041 (3R,4R)-4-[[[3-ethyl-7-[[5-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562041 CCc1cnn2c(NCc3cn4c(C(F)(F)F)cccc4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C23H27F3N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-475OAU SCHEMBL23562014 (3R,4R)-4-[[[3-cyclopropyl-7-[[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562014 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2cn3ccc(C(F)(F)F)cc3n2)n2ncc(C3CC3)c2n1 Degrader C24H27F3N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-8B0RBY SCHEMBL20702925 (6S)-5-[4-(6-methoxypyridin-3-yl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one; SCHEMBL29842575; KDFDNYYGLNRWPN-VIFPVBQESA-N; (6S)-5-[4-(6-methoxypyridin-3-yl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one COC1=CC=C(C2=CC=C(C3=NNC(=O)O[C@H]3C)C=C2C(F)(F)F)C=N1 Stabilizer C17H14F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-RWUJWO SCHEMBL20702931 (6S)-5-[4-(4-methoxyphenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one; SCHEMBL29842858; QQWHXUAAHPGCKJ-JTQLQIEISA-N; (6S)-5-[4-(4-methoxyphenyl)-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one COC1=CC=C(C2=CC=C(C3=NNC(=O)O[C@H]3C)C=C2C(F)(F)F)C=C1 Stabilizer C18H15F3N2O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-V8OQR2 SCHEMBL23561782 (3R,4R)-4-[[[3-cyclopropyl-7-[(5,6-difluoro-1-methylbenzimidazol-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561782 Cn1c(CNc2cc(NC[C@H]3CCNC[C@@H]3O)nc3c(C4CC4)cnn23)nc2cc(F)c(F)cc21 Degrader C24H28F2N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-635GDO SCHEMBL23562103 (3R,4R)-4-[[[3-cyclopropyl-7-[[5-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562103 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2cn3c(C(F)(F)F)cccc3n2)n2ncc(C3CC3)c2n1 Degrader C24H27F3N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-HLFQR3 SCHEMBL20703072 US11427553, Example 189; SCHEMBL30580654; ARWVVDBWISSNEP-NSHDSACASA-N; BDBM568727; US11427553, Example 189; (6S)-6-Methyl-5-[4'-methyl-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; (6S)-6-methyl-5-[4-(4-methylphenyl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one CC1=CC=C(C2=CC=C(C3=NNC(=O)O[C@H]3C)C=C2C(F)(F)F)C=C1 Stabilizer C18H15F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-PD2CZM SCHEMBL20702927 US11427553, Example 190; GYOWSDLEDJOFED-ZETCQYMHSA-N; BDBM568728; US11427553, Example 190; (6S)-5-[4-[1-(difluoromethyl)pyrazol-4-yl]-3-(trifluoromethyl)phenyl]-6-methyl-3,6-dihydro-1,3,4-oxadiazin-2-one; (6S)-5-{4-[1-(Difluoromethyl)-1H-pyrazol-4-yl]-3-(trifluoromethyl)phenyl}-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC(C(F)(F)F)=C(C2=CN(C(F)F)N=C2)C=C1 Stabilizer C15H11F5N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-6OISUN SCHEMBL23562104 (3R,4R)-4-[[[7-[[6-cyclopropyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methylamino]-3-ethylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562104 CCc1cnn2c(NCc3cn4cc(C5CC5)cc(C(F)(F)F)c4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C26H31F3N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-6GANKV SCHEMBL23561766 (3R,4R)-4-[[[3-cyclopropyl-7-[[5-methyl-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561766 Cc1cc(C(F)(F)F)cc2nc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)cn12 Degrader C25H29F3N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-U3SR81 WO2019025562-A1_191 . C[C@H]1OC(=O)NN=C1C1=CC(C(F)(F)F)=C(C2=CN(C(F)F)N=C2)C=C1 Stabilizer C15H11F5N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-YQ94R9 WO2019025562-A1_192 . C[C@H]1OC(=O)NN=C1C1=CC(C(F)(F)F)=C(C2=CC=C(F)C=C2)C=C1 Stabilizer C17H12F4N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-ILE9G6 SCHEMBL23561767 (3R,4R)-4-[[[3-cyclopropyl-7-[[6-methyl-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561767 Cc1cn2cc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)nc2cc1C(F)(F)F Degrader C25H29F3N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-6UGHMB SCHEMBL23561768 (3R,4R)-4-[[[3-cyclopropyl-7-[(5-propan-2-yloxyimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561768 CC(C)Oc1cccc2nc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)cn12 Degrader C26H34N8O2 CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-33OQRA SCHEMBL20702601 US11427553, Example 193; PTJJQADRERZTSY-UHFFFAOYSA-N; BDBM568731; US11427553, Example 193; 5-[4-[1-(Difluoromethyl)pyrazol-4-yl]-3-fluoro-5-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[1-(Difluoromethyl)-1H-pyrazol-4-yl]-3-fluoro-5-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(C3=CN(C(F)F)N=C3)C(F)=C2)CO1 Stabilizer C14H8F6N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-KB0FO1 SCHEMBL20702528 US11427553, Example 195; SCHEMBL29842616; VJHAQTKDSPEXPQ-UHFFFAOYSA-N; BDBM568732; US11427553, Example 195; 5-[3-(Difluoromethyl)-4-[1-(difluoromethyl)pyrazol-4-yl]phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{3-(Difluoromethyl)-4-[1-(difluoromethyl)-1H-pyrazol-4-yl]phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)F)=C(C3=CN(C(F)F)N=C3)C=C2)CO1 Stabilizer C14H10F4N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-7WSHQL WO2021122745-A1_H-APPAMP-042 . O[C@H]1CNCC[C@@H]1CNc1cc(NCC2=CN3C=C(C4CC4)C=C(C(F)(F)F)C3N2)n2ncc(C3CC3)c2n1 Degrader C27H33F3N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-1N2RYT SCHEMBL23561785 (3R,4R)-4-[[[7-[(5,7-dimethylimidazo[1,2-a]pyrimidin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561785 Cc1cc(C)n2cc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C(C)C)cnn34)nc2n1 Degrader C24H33N9O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-7OIFHG SCHEMBL20703116 US11427553, Example 196; SCHEMBL29842466; PFPFPCWJWPYXQM-JTQLQIEISA-N; BDBM568733; US11427553, Example 196; (6S)-6-methyl-5-[4-(morpholin-4-ylmethyl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; (6S)-6-Methyl-5-{4-[(morpholin-4-yl)methyl]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one C[C@@H]1OC(=O)NN=C1C1=CC(C(F)(F)F)=C(CN2CCOCC2)C=C1 Stabilizer C16H18F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-DK5O7K SCHEMBL20702655 US11427553, Example 197; SCHEMBL29842768; LWFOWEGIOLZSAB-UHFFFAOYSA-N; BDBM568734; US11427553, Example 197; 5-[4-(Morpholin-4-ylmethyl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(Morpholin-4-yl)methyl]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(CN3CCOCC3)C=C2)CO1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-D59F08 SCHEMBL23562892 (3R,4R)-4-[[[7-[(7-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562892 CC(C)c1cnn2c(NCc3nc4cc(C5CC5)ccn4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C25H33N9O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-U3L2P8 SCHEMBL25172955 (3R,4R)-4-[[[3-cyclopropyl-7-[(7-phenylimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL25172955 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2cn3ccc(-c4ccccc4)cc3n2)n2ncc(C3CC3)c2n1 Degrader C29H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-Y1ARCW SCHEMBL20703188 US11427553, Example 198; SCHEMBL30692587; FWYQCYVILNCMID-UHFFFAOYSA-N; BDBM568735; US11427553, Example 198; 5-[3-(Difluoromethyl)-4-(4-fluorophenyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[2-(Difluoromethyl)-4'-fluoro[1,1'-biphenyl]-4-yl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC=C(C3=CC=C(F)C=C3)C(C(F)F)=C2)CO1 Stabilizer C16H11F3N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-87DSVR SCHEMBL20702547 US11427553, Example 199; SCHEMBL30580661; LKPHAELTCVRPDD-UHFFFAOYSA-N; BDBM568736; US11427553, Example 199; 5-[4-(4-Chlorophenyl)-3-(difluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4'-Chloro-2-(difluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC=C(C3=CC=C(Cl)C=C3)C(C(F)F)=C2)CO1 Stabilizer C16H11ClF2N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-C1Z9SO SCHEMBL20702632 US11427553, Example 20; BDBM568576; US11427553, Example 20; (rac)-6-Methyl-5-[4-(morpholin-4-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1OC(=O)NN=C1C1=CC=C(N2CCOCC2)C=C1 Stabilizer C14H17N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-CNZ6XY SCHEMBL20702863 US11427553, Example 200; UVPBMSDTJZLQJH-UHFFFAOYSA-N; BDBM568737; US11427553, Example 200; 5-[3-(Difluoromethyl)-4-(6-methylpyridin-3-yl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[3-(Difluoromethyl)-4-(6-methylpyridin-3-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1=CC=C(C2=CC=C(C3=NNC(=O)OC3)C=C2C(F)F)C=N1 Stabilizer C16H13F2N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-0DHH92 SCHEMBL20703046 US11427553, Example 201; YQNZHHDYPPXVSY-UHFFFAOYSA-N; BDBM568738; US11427553, Example 201; 5-[4-(Cyclopenten-1-yl)-3-(difluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(Cyclopent-1-en-1-yl)-3-(difluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC=C(C3=CCCC3)C(C(F)F)=C2)CO1 Stabilizer C15H14F2N2O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-1IT9WF SCHEMBL20702896 US11427553, Example 202; SCHEMBL30692608; WXMGJIXCKGQRLA-UHFFFAOYSA-N; BDBM568739; US11427553, Example 202; 5-[3-(difluoromethyl)-4-(1H-pyrazol-4-yl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[3-(Difluoromethyl)-4-(1H-pyrazol-4-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC=C(C3=CNN=C3)C(C(F)F)=C2)CO1 Stabilizer C13H10F2N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-TC7QQN SCHEMBL20702729 US11427553, Example 203; SCHEMBL29842891; LKAOHDKDUDPAPP-UHFFFAOYSA-N; BDBM568740; US11427553, Example 203; 5-[4-(3-Hydroxy-3-methylazetidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(3-Hydroxy-3-methylazetidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1(O)CN(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)C1 Stabilizer C14H14F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-8MISFF SCHEMBL29842550 5-[4-[[(2R)-3,3,3-trifluoro-2-hydroxypropyl]amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NC[C@@H](O)C(F)(F)F)C=C2)CO1 Stabilizer C13H11F6N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-534B4F SCHEMBL20702932 US11427553, Example 205; SCHEMBL29842873; BRDRSCOFKHRZPN-UHFFFAOYSA-N; BDBM568742; US11427553, Example 205; 5-[4-(Oxan-4-ylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(Oxan-4-yl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NC3CCOCC3)C=C2)CO1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-OTZD3X WO2019025562-A1_206 . O=C1NN=C(C2=CC(C(F)(F)F)=C(NC3CC(O)C3)C=C2)CO1 Stabilizer C14H14F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-4KWLSH SCHEMBL20716555 US11427553, Example 207; LGMBOZFWFXOLRI-UHFFFAOYSA-N; BDBM568744; US11427553, Example 207; (rac)-5-{4-[2,4-Dimethylazetidin-1-yl]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-(2,4-Dimethylazetidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one CC1CC(C)N1C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H16F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-6M3RVJ SCHEMBL20716363 5-[4-[(2S,4R)-2,4-dimethylazetidin-1-yl]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; LGMBOZFWFXOLRI-DTORHVGOSA-N; 5-[4-[(2S,4R)-2,4-dimethylazetidin-1-yl]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H]1C[C@H](C)N1C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H16F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-AHXXXW SCHEMBL20705317 US11427553, Example 209; HETJACRWUIMVMX-JTQLQIEISA-N; BDBM568746; US11427553, Example 209; 5-[4-[[(2S)-3,3,3-trifluoro-2-hydroxypropyl]amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[3,3,3-Trifluoro-(2S)-hydroxypropyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NC[C@H](O)C(F)(F)F)C=C2)CO1 Stabilizer C13H11F6N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-MSJML3 SCHEMBL20702605 US11427553, Example 21; BDBM568577; US11427553, Example 21; 5-[3,5-Difluoro-4-(morpholin-4-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(F)=C(N3CCOCC3)C(F)=C2)CO1 Stabilizer C13H13F2N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-L0VXJQ SCHEMBL20702526 US11427553, Example 210; SCHEMBL29842906; BQKWMVANZSMRQL-UHFFFAOYSA-N; BDBM568747; US11427553, Example 210; 5-[4-[(2-Hydroxy-2-methylpropyl)amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(2-Hydroxy-2-methylpropyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC(C)(O)CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-L1WQSB SCHEMBL20702928 US11427553, Example 211; SCHEMBL20702930; SCHEMBL29842622; FDFBRHLJGWWTPU-XYPYZODXSA-N; BDBM568748; US11427553, Example 211; (trans)-5-[4-{[4-Hydroxycyclohexyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-[(4-Hydroxycyclohexyl)amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(N[C@H]3CC[C@H](O)CC3)C=C2)CO1 Stabilizer C16H18F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-ZVUWQG SCHEMBL20702738 US11427553, Example 212; SCHEMBL29842823; DTAMDCMHGINZIZ-UHFFFAOYSA-N; BDBM568749; US11427553, Example 212; 5-[4-(Cyclopropylmethylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(Cyclopropylmethyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NCC3CC3)C=C2)CO1 Stabilizer C14H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-SWGL23 SCHEMBL20702743 US11427553, Example 213; SCHEMBL29842675; WHOPZHXSQBNYFL-UHFFFAOYSA-N; BDBM568750; US11427553, Example 213; 5-[4-[(3-Methyloxetan-3-yl)methylamino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(3-Methyloxetan-3-yl)methyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1(CNC2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)COC1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-3LUF53 SCHEMBL20703254 US11427553, Example 214; DVNBHVVAZHOSQT-UHFFFAOYSA-N; BDBM568751; US11427553, Example 214; 5-[4-(3-Methoxypropylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(3-Methoxypropyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one COCCCNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-HNYB0D SCHEMBL20702628 US11427553, Example 215; WQZNIULOSVKZFL-UHFFFAOYSA-N; BDBM568752; US11427553, Example 215; (rac)-5-[4-({[Oxolan-2-yl]methyl}amino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-(Oxolan-2-ylmethylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NCC3CCCO3)C=C2)CO1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-C5G7YR SCHEMBL20705298 US11427553, Example 216; CDJVHFYAUYOQBH-SSDOTTSWSA-N; BDBM568753; US11427553, Example 216; 5-[4-[[(2R)-2-hydroxypropyl]amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(2R)-2-Hydroxypropyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one C[C@@H](O)CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C13H14F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-R8NC9W WO2019025562-A1_217 . C[C@@H](O)CCNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-72NS9Q SCHEMBL20702848 US11427553, Example 218; SCHEMBL29842909; CDJVHFYAUYOQBH-ZETCQYMHSA-N; BDBM568755; US11427553, Example 218; 5-[4-[[(2S)-2-hydroxypropyl]amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(2S)-2-Hydroxypropyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one C[C@H](O)CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C13H14F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-0ZNPWL SCHEMBL20702837 US11427553, Example 219; SCHEMBL29842887; IWUNUHKQPDUGIK-UHFFFAOYSA-N; BDBM568756; US11427553, Example 219; 5-[4-[(1-Hydroxycyclobutyl)methylamino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(1-Hydroxycyclobutyl)methyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NCC3(O)CCC3)C=C2)CO1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-0WBSIW SCHEMBL20702646 US11427553, Example 22; BDBM568830; US11427553, Example 22; 2-(Morpholin-4-yl)-5-(2-oxo-3,6-dihydro-2H-1,3,4-oxadiazin-5-yl)benzonitrile N#CC1=C(N2CCOCC2)C=CC(C2=NNC(=O)OC2)=C1 Stabilizer C14H14N4O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-7WAQTV SCHEMBL20702811 US11427553, Example 220; SCHEMBL30692583; FYVQHFOKZCWSQL-UHFFFAOYSA-N; BDBM568757; US11427553, Example 220; 5-[4-(3-Methylbutylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(3-Methylbutyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC(C)CCNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H18F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-3I0UYH SCHEMBL20702527 US11427553, Example 221; SCHEMBL29842567; UCSCXOFPNHJIGF-UHFFFAOYSA-N; BDBM568758; US11427553, Example 221; 5-[4-(2-Methylpropylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(2-Methylpropyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC(C)CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H16F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-5F156W SCHEMBL20702944 US11427553, Example 222; SCHEMBL29842880; IBBJDXMABDCWFR-UHFFFAOYSA-N; BDBM568759; US11427553, Example 222; 5-[4-(2-Methoxyethylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(2-Methoxyethyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one COCCNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C13H14F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-6BMX01 SCHEMBL20702574 US11427553, Example 223; SCHEMBL29842672; VBRPITHMSDKIQH-UHFFFAOYSA-N; BDBM568760; US11427553, Example 223; 5-[4-[Ethyl(methyl)amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[Ethyl(methyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CCN(C)C1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C13H14F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-4E2T4A SCHEMBL20702761 US11427553, Example 224; SCHEMBL30692588; FSSROFZZQZTZML-UHFFFAOYSA-N; BDBM568761; US11427553, Example 224; 5-[4-(Tert-butylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(tert-Butylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC(C)(C)NC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H16F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-G0XRW0 SCHEMBL20702531 US11427553, Example 225; SCHEMBL29842654; WQZNIULOSVKZFL-SNVBAGLBSA-N; BDBM568762; US11427553, Example 225; 5-[4-({[(2R)-Oxolan-2-yl]methyl}amino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-[[(2R)-oxolan-2-yl]methylamino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NC[C@H]3CCCO3)C=C2)CO1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-AO1VS1 SCHEMBL20702936 US11427553, Example 226; SCHEMBL29842699; FQPXYNARCNENKV-UHFFFAOYSA-N; BDBM568763; US11427553, Example 226; 5-[4-(Pyrazin-2-ylmethylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(Pyrazin-2-yl)methyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NCC3=CN=CC=N3)C=C2)CO1 Stabilizer C15H12F3N5O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-ICKLN1 SCHEMBL20702885 US11427553, Example 227; SCHEMBL29842747; BEMLSYVAFRQIIR-UHFFFAOYSA-N; BDBM568764; US11427553, Example 227; 5-[4-(4-Hydroxypiperidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(4-Hydroxypiperidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(N3CCC(O)CC3)C=C2)CO1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-0HQVJC SCHEMBL20702736 US11427553, Example 228; SCHEMBL29842715; IQHZVNOJYBEWSF-VIFPVBQESA-N; BDBM568765; US11427553, Example 228; 5-[4-[[(2S)-1-hydroxybutan-2-yl]amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(2S)-1-Hydroxybutan-2-yl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC[C@@H](CO)NC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-1QFSGN SCHEMBL20703045 US11427553, Example 229; SCHEMBL26364219; IYOGBIHWMLYILM-UHFFFAOYSA-N; BDBM568766; US11427553, Example 229; (rac)-5-[4-(3-hydroxypiperidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-(3-Hydroxypiperidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(N3CCCC(O)C3)C=C2)CO1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-TS0243 SCHEMBL20702705 US11427553, Example 23; SCHEMBL30692584; BDBM568578; US11427553, Example 23; 3-Chloro-2-(morpholin-4-yl)-5-(2-oxo-3,6-dihydro-2H-1,3,4-oxadiazin-5-yl)benzonitrile N#CC1=C(N2CCOCC2)C(Cl)=CC(C2=NNC(=O)OC2)=C1 Stabilizer C14H13ClN4O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-IM62IL SCHEMBL20702921 US11427553, Example 230; SCHEMBL26364221; JKERQASOWSAQGV-UHFFFAOYSA-N; BDBM568767; US11427553, Example 230; (rac)-1-[4-(2-Oxo-3,6-dihydro-2H-1,3,4-oxadiazin-5-yl)-2-(trifluoromethyl)phenyl]piperidine-3-carboxamide; 1-[4-(2-Oxo-3,6-dihydro-1,3,4-oxadiazin-5-yl)-2-(trifluoromethyl)phenyl]piperidine-3-carboxamide NC(=O)C1CCCN(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)C1 Stabilizer C16H17F3N4O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-IEY64X SCHEMBL20702817 US11427553, Example 231; SCHEMBL29842696; NVXQITVLIURHGR-UHFFFAOYSA-N; BDBM568768; US11427553, Example 231; 5-[4-[(3-Hydroxy-2,2-dimethylpropyl)amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(3-Hydroxy-2,2-dimethylpropyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC(C)(CO)CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H18F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-Y92RPN SCHEMBL20702877 US11427553, Example 232; SCHEMBL29842816; UUSSKISSJWVYTA-UHFFFAOYSA-N; BDBM568769; US11427553, Example 232; 5-[4-(4,4-Difluoropiperidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(4,4-Difluoropiperidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(N3CCC(F)(F)CC3)C=C2)CO1 Stabilizer C15H14F5N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-ZHLZCR WO2019025562-A1_233 . O=C1NN=C(C2=CC(C(F)(F)F)=C(N[C@@H]3CC4CC45CCC35)C=C2)CO1 Stabilizer C18H18F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-F50E8M WO2019025562-A1_234 . O=C1NN=C(C2=CC(C(F)(F)F)=C(N3CC[C@H](O)C3)C=C2)CO1 Stabilizer C14H14F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-K97FCO SCHEMBL29842781 5-[4-[[(2R)-2-hydroxy-3-methoxypropyl]amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one COC[C@H](O)CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H16F3N3O4 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-LVNKCZ SCHEMBL20702916 US11427553, Example 236; BXJGRMQPXQFDQL-UHFFFAOYSA-N; BDBM568773; US11427553, Example 236; 5-[4-[(2-Methylpyrazol-3-yl)methylamino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(1-Methyl-1H-pyrazol-5-yl)methyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CN1N=CC=C1CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H14F3N5O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-YTCMLY SCHEMBL20703243 US11427553, Example 237; ZCJNURSCOKBXIF-UHFFFAOYSA-N; BDBM568774; US11427553, Example 237; 5-[4-(1H-pyrazol-5-ylmethylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(1H-Pyrazol-3-yl)methyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NCC3=NNC=C3)C=C2)CO1 Stabilizer C14H12F3N5O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-G7CDFA SCHEMBL20702793 US11427553, Example 238; STCOVSUSIUIOEK-UHFFFAOYSA-N; BDBM568775; US11427553, Example 238; 5-[4-(2-Pyrazol-1-ylethylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[2-(1H-Pyrazol-1-yl)ethyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NCCN3C=CC=N3)C=C2)CO1 Stabilizer C15H14F3N5O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-OWJLJD SCHEMBL20702617 US11427553, Example 239; SCHEMBL29842563; HEXIGMPICOZSLA-UHFFFAOYSA-N; BDBM568776; US11427553, Example 239; 1-[4-(2-Oxo-3,6-dihydro-1,3,4-oxadiazin-5-yl)-2-(trifluoromethyl)phenyl]piperidine-4-carbonitrile; 1-[4-(2-Oxo-3,6-dihydro-2H-1,3,4-oxadiazin-5-yl)-2-(trifluoromethyl)phenyl]piperidine-4-carbonitrile N#CC1CCN(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)CC1 Stabilizer C16H15F3N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-DN41XY SCHEMBL20702858 US11427553, Example 24; SCHEMBL29842674; BDBM568579; US11427553, Example 24; 5-{4-[2,6-Dimethylmorpholin-4-yl]-3-fluorophenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CC1CN(C2=C(F)C=C(C3=NNC(=O)OC3)C=C2)CC(C)O1 Stabilizer C15H18FN3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-032GFV SCHEMBL29842601 5-[4-[[(1R)-1-cyclopropylethyl]amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one C[C@@H](NC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1)C1CC1 Stabilizer C15H16F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-IF9QZP SCHEMBL29842619 5-[4-[[(2R)-2-ethoxypropyl]amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one CCO[C@H](C)CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C15H18F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-NAMKZH SCHEMBL20702602 US11427553, Example 242; SCHEMBL26364236; RHLKPHWSFKZMIP-UHFFFAOYSA-N; BDBM568779; US11427553, Example 242; 5-[4-(2-Methoxypropylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; (rac)-5-{4-[(2-Methoxypropyl)amino]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one COC(C)CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-73ZUES SCHEMBL20702730 US11427553, Example 243; SCHEMBL30692580; FWCZQOKJZOETPW-UHFFFAOYSA-N; BDBM568780; US11427553, Example 243; 5-[4-(3-Ethoxyazetidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-(3-Ethoxyazetidin-1-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one CCOC1CN(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)C1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-QY1T9M SCHEMBL20702616 US11427553, Example 244; SCHEMBL29842756; PICPVDDPDQYUGM-UHFFFAOYSA-N; BDBM568781; US11427553, Example 244; 5-[4-(Pyrimidin-2-ylmethylamino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(Pyrimidin-2-yl)methyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NCC3=NC=CC=N3)C=C2)CO1 Stabilizer C15H12F3N5O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-VBM30J WO2019025562-A1_245 . O=C1NN=C(C2=CC(C(F)(F)F)=C(NC[C@H]3CCOC3)C=C2)CO1 Stabilizer C15H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-PZA5OK SCHEMBL20702865 US11427553, Example 246; SCHEMBL29842695; GRCVFQWWWBIXTN-QMMMGPOBSA-N; BDBM568783; US11427553, Example 246; 5-[4-[[(2S)-4-hydroxybutan-2-yl]amino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-[4-{[(2S)-4-Hydroxybutan-2-yl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one C[C@@H](CCO)NC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C14H16F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-NWH7Q5 SCHEMBL29842784 5-[4-[[(3R)-6-oxopiperidin-3-yl]methylamino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1CC[C@H](CNC2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)CN1 Stabilizer C16H17F3N4O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-59HZ49 SCHEMBL20702555 US11427553, Example 248; SCHEMBL22697058; QHAMCQNWQKUPPD-UHFFFAOYSA-N; BDBM568785; US11427553, Example 248; (rac)-5-[4-{[(2,2-Dimethylcyclopropyl)methyl]amino}-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-[(2,2-Dimethylcyclopropyl)methylamino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one CC1(C)CC1CNC1=C(C(F)(F)F)C=C(C2=NNC(=O)OC2)C=C1 Stabilizer C16H18F3N3O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-GEHUL9 SCHEMBL20702835 US11427553, Example 249; SCHEMBL29842836; KOGQRLQEEDTHCO-UHFFFAOYSA-N; BDBM568786; US11427553, Example 249; 5-[4-({[1-(Hydroxymethyl)cyclobutyl]methyl}amino)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one; 5-[4-[[1-(Hydroxymethyl)cyclobutyl]methylamino]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(NCC3(CO)CCC3)C=C2)CO1 Stabilizer C16H18F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-5JGI2H SCHEMBL20702979 US11427553, Example 250; SCHEMBL29842676; HGYOZMPWRRSOIO-VIFPVBQESA-N; BDBM568787; US11427553, Example 250; 5-[4-[(2S)-2-(hydroxymethyl)azetidin-1-yl]-3-(trifluoromethyl)phenyl]-3,6-dihydro-1,3,4-oxadiazin-2-one; 5-{4-[(2S)-2-(Hydroxymethyl)azetidin-1-yl]-3-(trifluoromethyl)phenyl}-3,6-dihydro-2H-1,3,4-oxadiazin-2-one O=C1NN=C(C2=CC(C(F)(F)F)=C(N3CC[C@H]3CO)C=C2)CO1 Stabilizer C14H14F3N3O3 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-2E59W5 SCHEMBL20702845 US11427553, Example 251; SCHEMBL29842558; DTXHZZLZPOYJPR-UHFFFAOYSA-N; BDBM568788; US11427553, Example 251; 3-Methyl-1-[4-(2-oxo-3,6-dihydro-1,3,4-oxadiazin-5-yl)-2-(trifluoromethyl)phenyl]azetidine-3-carbonitrile; 3-Methyl-1-[4-(2-oxo-3,6-dihydro-2H-1,3,4-oxadiazin-5-yl)-2-(trifluoromethyl)phenyl]azetidine-3-carbonitrile CC1(C#N)CN(C2=C(C(F)(F)F)C=C(C3=NNC(=O)OC3)C=C2)C1 Stabilizer C15H13F3N4O2 PDE3A;PDE3B;SLFN12 Q14432/Q13370/Q8IYM2 . WO-2019025562-A1 TPD-X7M15Q SCHEMBL23531041 (3R,4R)-4-[[[7-[(5-methylimidazo[1,2-a]pyridin-3-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23531041 Cc1cccc2ncc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C(C)C)cnn34)n12 Degrader C24H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-4KFLOV WO2021122745-A1_H-APPAMP-002 . CC(C)c1cnn2c(NCc3cn4cccnc4n3)cc(NCC3CCNC[C@@H]3O)nc12 Degrader C22H29N9O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-JAJD6G SCHEMBL23530616 (3R,4R)-4-[[[7-(imidazo[1,2-a]pyridin-2-ylmethylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23530616 CC(C)c1cnn2c(NCc3cn4ccccc4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C23H30N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-756JVG SCHEMBL23530993 (3R,4R)-4-[[[7-[(8-methylimidazo[1,2-a]pyridin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23530993 Cc1cccn2cc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C(C)C)cnn34)nc12 Degrader C24H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-82YJFQ SCHEMBL23530878 (3R,4R)-4-[[[7-(1H-benzimidazol-2-ylmethylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23530878 CC(C)c1cnn2c(NCc3nc4ccccc4[nH]3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C23H30N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-P665RG SCHEMBL23531045 (3R,4R)-4-[[[7-[(1-methylbenzimidazol-5-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23531045 CC(C)c1cnn2c(NCc3ccc4c(c3)ncn4C)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C24H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-TMCCYH SCHEMBL23561772 (3R,4R)-4-[[[7-[(3-methylimidazo[2,1-b][1,3]thiazol-6-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561772 Cc1csc2nc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C(C)C)cnn34)cn12 Degrader C22H30N8OS CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-4MO2W7 SCHEMBL23562145 (3R,4R)-4-[[[7-[(6-methylimidazo[1,2-a]pyridin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562145 Cc1ccc2nc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C(C)C)cnn34)cn2c1 Degrader C24H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-F1N7DJ SCHEMBL23562106 (3R,4R)-4-[[[7-[(7-methylimidazo[1,2-a]pyridin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562106 Cc1ccn2cc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C(C)C)cnn34)nc2c1 Degrader C24H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-CQ6L7B SCHEMBL23562137 (3R,4R)-4-[[[7-[(5-methylimidazo[1,2-a]pyridin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562137 Cc1cccc2nc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C(C)C)cnn34)cn12 Degrader C24H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-67VB20 SCHEMBL23562134 (3R,4R)-4-[[[7-[(6-fluoroimidazo[1,2-a]pyridin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562134 CC(C)c1cnn2c(NCc3cn4cc(F)ccc4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C23H29FN8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-XNB4UM SCHEMBL23561774 (3R,4R)-4-[[[7-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23561774 CC(C)c1cnn2c(NCc3cn4cc(Cl)ccc4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C23H29ClN8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-MLBW70 SCHEMBL23562132 (3R,4R)-4-[[[7-[(8-cyclopropylimidazo[1,2-a]pyridin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562132 CC(C)c1cnn2c(NCc3cn4cccc(C5CC5)c4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C26H34N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-CZWSLZ SCHEMBL23562133 (3R,4R)-4-[[[3-propan-2-yl-7-(quinolin-2-ylmethylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562133 CC(C)c1cnn2c(NCc3ccc4ccccc4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C25H31N7O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-9OYBDK Cdk7/12-IN-1 CDK7/12-IN-1; 2654075-94-0; SCHEMBL23562149; DA-51723; HY-46568; MS-28509; CS-0373738; (3R,4R)-4-[[[7-[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol Cc1ccn2c(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C(C)C)cnn34)c(C)nc2c1 Degrader C25H34N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-ORBEOJ SCHEMBL23562148 (3R,4R)-4-[[[7-(imidazo[1,2-a]pyridin-3-ylmethylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562148 CC(C)c1cnn2c(NCc3cnc4ccccn34)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C23H30N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-WVFRO6 SCHEMBL23562150 (3R,4R)-4-[[[7-[(3-methylimidazo[1,2-a]pyridin-2-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562150 Cc1c(CNc2cc(NC[C@H]3CCNC[C@@H]3O)nc3c(C(C)C)cnn23)nc2ccccn12 Degrader C24H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-VWUYMY WO2021122745-A1_H-APPAMP-018 . CC(C)c1cnn2c(NC(C)(C)c3cn4ccccc4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C25H34N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-N1JNDR SCHEMBL23562032 (3R,4R)-4-[[[7-(1-imidazo[1,2-a]pyridin-2-ylethylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562032 CC(C)c1cnn2c(NC(C)c3cn4ccccc4n3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C24H32N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-ZU80UU SCHEMBL23562143 (3R,4R)-4-[[[7-(1-benzofuran-2-ylmethylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562143 CC(C)c1cnn2c(NCc3cc4ccccc4o3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C24H30N6O2 CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-R34YPF SCHEMBL23562153 (3R,4R)-4-[[[3-propan-2-yl-7-(quinolin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562153 CC(C)c1cnn2c(NCc3cnc4ccccc4c3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C25H31N7O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-JB1VH8 SCHEMBL23562157 (3R,4R)-4-[[[3-cyclopropyl-7-[(8-methylimidazo[1,2-a]pyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL23562157 Cc1cccn2cc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C5CC5)cnn34)nc12 Degrader C24H30N8O CDK7;CDK12;CCNK P50613/Q9NYV4/O75909 DDB1 WO-2021122745-A1 TPD-MYKAJU SCHEMBL25209797 4-[4-[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25209797 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)CC2)c(F)c1 Degrader C32H29FN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-CGL1G7 SCHEMBL25249568 4-[4-[4-[[2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,3-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25249568 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)c(F)c3F)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-8BEZ2U SCHEMBL25225220 4-[4-[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,3-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25225220 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c(F)c3F)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-SRX9KK SCHEMBL25225218 4-[4-[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,3-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25225218 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)c(F)c3F)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-W6AFJQ SCHEMBL25233571 4-[4-[4-[[2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,5-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25233571 N#Cc1ccc(N2CCC(Sc3cc(F)c(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)cc3F)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-ZMMRGG SCHEMBL25230010 4-[4-[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,5-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25230010 N#Cc1ccc(N2CCC(Sc3cc(F)c(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3F)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-SG7OAR SCHEMBL25212081 4-[4-[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,5-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25212081 N#Cc1ccc(N2CCC(Sc3cc(F)c(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3F)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-CT6371 SCHEMBL25204885 4-[4-[4-[[2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,6-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25204885 N#Cc1ccc(N2CCC(Sc3c(F)cc(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)cc3F)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-S8GP6E SCHEMBL25229127 4-[4-[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,6-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25229127 N#Cc1ccc(N2CCC(Sc3c(F)cc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3F)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-04AMAF SCHEMBL25210511 4-[4-[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,6-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25210511 N#Cc1ccc(N2CCC(Sc3c(F)cc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3F)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-JJ06EH SCHEMBL25345446 4-[4-[5-[[2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-6-methylpyridin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25345446 Cc1nc(SC2CCN(c3ccc(C#N)cc3F)CC2)ccc1COc1cccc2c1CN([C@@H]1CCC(=O)NC1=O)C2=O Degrader C32H30FN5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-9RPVP6 SCHEMBL25344945 4-[4-[5-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]-6-methylpyridin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25344945 Cc1nc(SC2CCN(c3ccc(C#N)cc3F)CC2)ccc1COc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O Degrader C32H30FN5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-92GEH3 SCHEMBL25254999 4-[4-[5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-6-methylpyridin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25254999 Cc1nc(SC2CCN(c3ccc(C#N)cc3F)CC2)ccc1COc1cccc2c1CN([C@H]1CCC(=O)NC1=O)C2=O Degrader C32H30FN5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-LB442Y SCHEMBL25206482 4-[4-[2-chloro-4-[[2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25206482 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)cc3Cl)CC2)c(F)c1 Degrader C32H28ClFN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-S1VUQB SCHEMBL25230488 4-[4-[2-chloro-4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25230488 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3Cl)CC2)c(F)c1 Degrader C32H28ClFN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-05X91J SCHEMBL25230487 4-[4-[2-chloro-4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25230487 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3Cl)CC2)c(F)c1 Degrader C32H28ClFN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-MOQZ7Y SCHEMBL25664172 4-[3-[5-[[2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]pyridin-2-yl]sulfanylpyrrolidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25664172 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)cn3)C2)c(F)c1 Degrader C30H26FN5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-0711QN SCHEMBL25233466 4-[3-[5-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]pyridin-2-yl]sulfanylpyrrolidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25233466 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cn3)C2)c(F)c1 Degrader C30H26FN5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-K89XHT SCHEMBL25200650 4-[3-[5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]pyridin-2-yl]sulfanylpyrrolidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25200650 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cn3)C2)c(F)c1 Degrader C30H26FN5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-I2FWLI SCHEMBL25228903 4-[3-[4-[[2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]sulfanylazetidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25228903 N#Cc1ccc(N2CC(Sc3ccc(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)cc3)C2)c(F)c1 Degrader C30H25FN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-75W5RB SCHEMBL25220144 4-[3-[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]sulfanylazetidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25220144 N#Cc1ccc(N2CC(Sc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)C2)c(F)c1 Degrader C30H25FN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-QLU5GG SCHEMBL25212018 4-[3-[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]sulfanylazetidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25212018 N#Cc1ccc(N2CC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3)C2)c(F)c1 Degrader C30H25FN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-516Q9X SCHEMBL25207955 4-[4-[5-[[2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-6-fluoropyridin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25207955 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)c(F)n3)CC2)c(F)c1 Degrader C31H27F2N5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-I0DV4O SCHEMBL25343968 4-[4-[5-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]-6-fluoropyridin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25343968 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c(F)n3)CC2)c(F)c1 Degrader C31H27F2N5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-5DFQPH SCHEMBL25209021 4-[4-[5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-6-fluoropyridin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25209021 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)c(F)n3)CC2)c(F)c1 Degrader C31H27F2N5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-8XU73Z SCHEMBL25232774 4-[4-[4-[[2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-3,5-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25232774 N#Cc1ccc(N2CCC(Sc3cc(F)c(COc4cccc5c4CN([C@@H]4CCC(=O)NC4=O)C5=O)c(F)c3)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-NYJQLX SCHEMBL24642979 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-fluoro-5-methylbenzenesulfonamide\; SCHEMBL24642979 Cc1ccc(F)c(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)c1 Degrader C20H16FN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-0944N9 CHEMBL5090015 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-methoxybenzenesulfonamide\; CHEMBL5090015; SCHEMBL24273969 COc1ccccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C20H17N3O7S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-Q9WZOF SCHEMBL24642911 5-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-methoxybenzenesulfonamide\; SCHEMBL24642911 COc1ccc(Cl)cc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C20H16ClN3O7S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-51XQ2O SCHEMBL25211094 4-[4-[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-3,5-difluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25211094 N#Cc1ccc(N2CCC(Sc3cc(F)c(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)c(F)c3)CC2)c(F)c1 Degrader C32H27F3N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-YKJOZL SCHEMBL24642965 4-bromo-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide\; SCHEMBL24642965 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc(Br)cc4OC(F)(F)F)cc3C2=O)C(=O)N1 Degrader C20H13BrF3N3O7S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-0U0UFC SCHEMBL24274170 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2,6-dimethylbenzenesulfonamide\; SCHEMBL24274170 Cc1cccc(C)c1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C21H19N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-SQAS76 SCHEMBL24642821 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-4-fluorobenzenesulfonamide\; SCHEMBL24642821 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc(F)cc4)cc3C2=O)C(=O)N1 Degrader C19H14FN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-1P6M60 SCHEMBL24642826 N-[4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]sulfamoyl]phenyl]acetamide\; SCHEMBL24642826 CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C21H18N4O7S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-ICX074 WO2022017365-A1_2 . O=Nc1ccc(N2CCC(Sc3ccc(COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)CC2)c(F)c1 Degrader C31H27FN4O6S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-HMGSCP SCHEMBL24642978 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-4-methoxybenzenesulfonamide\; SCHEMBL24642978 COc1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C20H17N3O7S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-SFYTN6 CHEMBL5073414 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-methylbenzenesulfonamide\; CHEMBL5073414; SCHEMBL24274027 Cc1ccccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C20H17N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-VZOZZ1 SCHEMBL25223071 4-[4-[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25223071 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3)CC2)c(F)c1 Degrader C32H29FN4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-UGPQ1Y SCHEMBL24273907 4-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]benzenesulfonamide\; SCHEMBL24273907 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3C2=O)C(=O)N1 Degrader C19H14ClN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-Q4FMBC SCHEMBL24642816 3-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-4-fluorobenzenesulfonamide\; SCHEMBL24642816 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc(F)c(Cl)c4)cc3C2=O)C(=O)N1 Degrader C19H13ClFN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-DM274L SCHEMBL24642850 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]thiophene-2-sulfonamide\; SCHEMBL24642850 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4cccs4)cc3C2=O)C(=O)N1 Degrader C17H13N3O6S2 GSPT1 P15170 CRBN WO-2022066835-A1 TPD-K405WJ SCHEMBL25207308 4-[4-[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2-fluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25207308 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3F)CC2)c(F)c1 Degrader C32H28F2N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-AQ7XHE SCHEMBL24642912 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-3-methylbenzenesulfonamide\; SCHEMBL24642912 Cc1cccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)c1 Degrader C20H17N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-F31WYY CHEMBL5079426 N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-3-(trifluoromethoxy)benzenesulfonamide\; CHEMBL5079426; SCHEMBL24274028; BDBM669520; US20240132463, Compound 2; N-(2-(2,6-dioxopiperidin-3-yl)-1,3- dioxoisoindolin-5-yl)-3- (trifluoromethoxy)benzenesulfonamide O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4cccc(OC(F)(F)F)c4)cc3C2=O)C(=O)N1 Degrader C20H14F3N3O7S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-CBS066 SCHEMBL25202225 4-[4-[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-3-fluorophenyl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25202225 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)c(F)c3)CC2)c(F)c1 Degrader C32H28F2N4O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-TVGWWD CHEMBL5078971 N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)benzenesulfonamide\; CHEMBL5078971; SCHEMBL24273908; BDBM669523; US20240132463, Compound 20; N-(2-(2,6-dioxopiperidin-3-yl)-1,3- dioxoisoindolin-5- yl)benzenesulfonamide O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccccc4)cc3C2=O)C(=O)N1 Degrader C19H15N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-EOBUWG SCHEMBL24273759 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]benzenesulfonamide\; SCHEMBL24273759 O=C1CCC(N2Cc3ccc(NS(=O)(=O)c4ccccc4)cc3C2=O)C(=O)N1 Degrader C19H17N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-73BLPH SCHEMBL24642910 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-4-fluorobenzenesulfonamide\; SCHEMBL24642910 O=C1CCC(N2Cc3ccc(NS(=O)(=O)c4ccc(F)cc4)cc3C2=O)C(=O)N1 Degrader C19H16FN3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-46PRWH SCHEMBL24642870 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-4-methoxybenzenesulfonamide\; SCHEMBL24642870 COc1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cc1 Degrader C20H19N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-08PCL9 SCHEMBL25208232 4-[4-[5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]pyridin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25208232 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cn3)CC2)c(F)c1 Degrader C31H28FN5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-STPG6Q SCHEMBL24642871 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-4-methylbenzenesulfonamide\; SCHEMBL24642871 Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cc1 Degrader C20H19N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-G3TUNI Z5000211081 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-4-(trifluoromethyl)benzenesulfonamide\; SCHEMBL24642913; Z5000211081 O=C1CCC(N2Cc3ccc(NS(=O)(=O)c4ccc(C(F)(F)F)cc4)cc3C2=O)C(=O)N1 Degrader C20H16F3N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-GJ2UPK SCHEMBL24642770 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-3-(trifluoromethoxy)benzenesulfonamide\; SCHEMBL24642770 O=C1CCC(N2Cc3ccc(NS(=O)(=O)c4cccc(OC(F)(F)F)c4)cc3C2=O)C(=O)N1 Degrader C20H16F3N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-W895I5 SCHEMBL25201841 4-[4-[5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]pyrimidin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25201841 N#Cc1ccc(N2CCC(Sc3ncc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cn3)CC2)c(F)c1 Degrader C30H27FN6O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-ZHUOFF SCHEMBL24643008 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-2-(trifluoromethyl)benzenesulfonamide\; SCHEMBL24643008 O=C1CCC(N2Cc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3C2=O)C(=O)N1 Degrader C20H16F3N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-OX53QJ SCHEMBL24642975 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-3-methoxybenzenesulfonamide\; SCHEMBL24642975 COc1cccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)c1 Degrader C20H19N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-CFAG32 SCHEMBL25230180 4-[4-[5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-6-fluoro-1-oxo-3H-isoindol-4-yl]oxymethyl]pyridin-2-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25230180 N#Cc1ccc(N2CCC(Sc3ccc(COc4cc(F)cc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cn3)CC2)c(F)c1 Degrader C31H27F2N5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-ECG0MC SCHEMBL24642815 4-tert-butyl-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]benzenesulfonamide\; SCHEMBL24642815 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C23H23N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-9ZYVSV SCHEMBL24642971 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-4-propan-2-ylbenzenesulfonamide\; SCHEMBL24642971 CC(C)c1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cc1 Degrader C22H23N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-OIVT2I SCHEMBL24643011 3-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-4-fluorobenzenesulfonamide\; SCHEMBL24643011 O=C1CCC(N2Cc3ccc(NS(=O)(=O)c4ccc(F)c(Cl)c4)cc3C2=O)C(=O)N1 Degrader C19H15ClFN3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-UT6F5S SCHEMBL24643009 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-3-(trifluoromethyl)benzenesulfonamide\; SCHEMBL24643009 O=C1CCC(N2Cc3ccc(NS(=O)(=O)c4cccc(C(F)(F)F)c4)cc3C2=O)C(=O)N1 Degrader C20H16F3N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-FXIJUG SCHEMBL25205188 4-[4-[6-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]pyridin-3-yl]sulfanylpiperidin-1-yl]-3-fluorobenzonitrile\; SCHEMBL25205188 N#Cc1ccc(N2CCC(Sc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)nc3)CC2)c(F)c1 Degrader C31H28FN5O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022017365-A1 TPD-1FHV48 SCHEMBL24642835 3-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-4-methylbenzenesulfonamide\; SCHEMBL24642835 Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cc1Cl Degrader C20H18ClN3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-38RNKF SCHEMBL24642809 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-2-fluoro-5-methylbenzenesulfonamide\; SCHEMBL24642809 Cc1ccc(F)c(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)c1 Degrader C20H18FN3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-Q32FMY SCHEMBL24273764 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-2-methylbenzenesulfonamide\; SCHEMBL24273764 Cc1ccccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C20H19N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-DKDN7O SCHEMBL24642817 3-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-2-methylbenzenesulfonamide\; SCHEMBL24642817 Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C20H18ClN3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-AUQSF9 SCHEMBL24642827 N-[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide\; SCHEMBL24642827 O=C1CCC(N2Cc3ccc(NS(=O)(=O)c4ccccc4OC(F)(F)F)cc3C2=O)C(=O)N1 Degrader C20H16F3N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-1MCHQM SCHEMBL24642822 1-(4-chlorophenyl)-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methanesulfonamide\; SCHEMBL24642822 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)Cc4ccc(Cl)cc4)cc3C2=O)C(=O)N1 Degrader C20H16ClN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-X8WSFP SCHEMBL24642781 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-1-(4-methylphenyl)methanesulfonamide\; SCHEMBL24642781 Cc1ccc(CS(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C21H19N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-L1IH7O SCHEMBL24642818 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-3-(trifluoromethyl)benzenesulfonamide\; SCHEMBL24642818 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4cccc(C(F)(F)F)c4)cc3C2=O)C(=O)N1 Degrader C20H14F3N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-ZNG4DI SCHEMBL24642784 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2,3-dihydro-1,4-benzodioxine-6-sulfonamide\; SCHEMBL24642784 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc5c(c4)OCCO5)cc3C2=O)C(=O)N1 Degrader C21H17N3O8S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-6SC9XA SCHEMBL24273945 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide\; SCHEMBL24273945 Cc1noc(C)c1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C18H16N4O7S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-98ABRJ SCHEMBL24642782 3-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-fluorobenzenesulfonamide\; SCHEMBL24642782 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4cccc(Cl)c4F)cc3C2=O)C(=O)N1 Degrader C19H13ClFN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-KJ0H7R SCHEMBL24642785 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-4-phenylbenzenesulfonamide\; SCHEMBL24642785 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc(-c5ccccc5)cc4)cc3C2=O)C(=O)N1 Degrader C25H19N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-U2KUMC SCHEMBL24642789 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]naphthalene-2-sulfonamide\; SCHEMBL24642789 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc5ccccc5c4)cc3C2=O)C(=O)N1 Degrader C23H17N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-SG6GUE SCHEMBL24642783 4-cyano-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]benzenesulfonamide\; SCHEMBL24642783 N#Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C20H14N4O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-DWTOG6 SCHEMBL24642857 2-bromo-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]benzenesulfonamide\; SCHEMBL24642857 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccccc4Br)cc3C2=O)C(=O)N1 Degrader C19H14BrN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-5OX0PU SCHEMBL24642894 4-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2,5-difluorobenzenesulfonamide\; SCHEMBL24642894 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4cc(F)c(Cl)cc4F)cc3C2=O)C(=O)N1 Degrader C19H12ClF2N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-1NE6VB SCHEMBL24642984 2-chloro-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-4-fluorobenzenesulfonamide\; SCHEMBL24642984 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc(F)cc4Cl)cc3C2=O)C(=O)N1 Degrader C19H13ClFN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-KVHCWY SCHEMBL24642962 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2,4,6-trimethylbenzenesulfonamide\; SCHEMBL24642962 Cc1cc(C)c(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)c(C)c1 Degrader C22H21N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-WTXATR CHEMBL5084741 3-chloro-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-methylbenzenesulfonamide\; CHEMBL5084741; SCHEMBL24273911; BDBM669521; NSC829445; US20240132463, Compound 5; NSC-829445; 3-chloro-N-(2-(2,6-dioxopiperidin-3- yl)-1,3-dioxoisoindolin-5-yl)-2- methylbenzenesulfonamide Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C20H16ClN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-QY7RGQ SCHEMBL24642983 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]benzenesulfonamide\; SCHEMBL24642983 O=C1CCC(N2Cc3cc(NS(=O)(=O)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C19H17N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-4RVC4Z SCHEMBL24642838 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-fluorobenzenesulfonamide\; SCHEMBL24642838 O=C1CCC(N2Cc3cc(NS(=O)(=O)c4ccc(F)cc4)ccc3C2=O)C(=O)N1 Degrader C19H16FN3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-KHVL0N SCHEMBL24642986 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-methoxybenzenesulfonamide\; SCHEMBL24642986 COc1ccc(S(=O)(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C20H19N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-RI3WMX SCHEMBL24643019 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-methylbenzenesulfonamide\; SCHEMBL24643019 Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C20H19N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-Z9W8OM WO-2022073469-A1_GS-001 . CC(=O)C(CCC(N)=O)N1C(=O)C2=C(/C=C(NCCCCCC(=O)N3CCCCC3)\C=C/2)C1=O Degrader C25H34N4O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JPJTBM SCHEMBL24291535 5-[[6-[4-[4-(8-Bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=C\N=C7\C=CC=C(Br)\C7=N\6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C35H35BrN8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-VCR8KN SCHEMBL24291536 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-pyrazol-1-ylpiperidin-1-yl)hexyl]amino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=CC=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C27H32N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-8QMI5F SCHEMBL27090606 2-[3-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]phenyl]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoroacetamide; SCHEMBL29589595 O=C1CCC(N2CC3=C(C=CC(CNC(=O)C(F)(F)C4=CC=CC(N5CCC(N6C=C(C7=C\N=C8\C=CC=C(Br)\C8=N\7)C=N6)CC5)=C4)=C3)C2=O)C(=O)N1 Degrader C38H33BrF2N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-W0VFEV SCHEMBL24289322 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL29590149 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C35H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-H1EDOQ SCHEMBL24291539 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-(4-quinolin-2-ylpyrazol-1-yl)piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL29589767 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7C=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C36H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-VLCM8I SCHEMBL24288794 5-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoro-5-oxopentanamide; SCHEMBL29589715 O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(F)(F)CCC(=O)N4CCC(N5C=C(C6=C\N=C7\C=CC=C(Br)\C7=N\6)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C35H33BrF2N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-M2LVXD SCHEMBL27091029 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-[4-(1,2,3,4-tetrahydroquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL29590729 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6CNC7=C(/C=C\C=C/7)N6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C35H40N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-K8V2FL SCHEMBL24290736 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-(4-pyrazin-2-ylpyrazol-1-yl)piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL29589534 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=NC=CN=C6)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C31H34N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-SDXCQC SCHEMBL24290734 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-phenylpiperidin-1-yl)hexyl]amino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(NCCCCCC(=O)N4CCC(C5=CC=CC=C5)CC4)C=C3C2=O)C(=O)N1 Degrader C30H34N4O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KV8VOJ SCHEMBL24290737 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-(4-morpholin-4-ylpiperidin-1-yl)-6-oxohexyl]amino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(NCCCCCC(=O)N4CCC(N5CCOCC5)CC4)C=C3C2=O)C(=O)N1 Degrader C28H37N5O6 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-7XUR3Y SCHEMBL24290059 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-piperidin-1-ylpiperidin-1-yl)hexyl]amino]isoindole-1,3-dione; SCHEMBL29589539 O=C1CCC(N2C(=O)C3=CC=C(NCCCCCC(=O)N4CCC(N5CCCCC5)CC4)C=C3C2=O)C(=O)N1 Degrader C29H39N5O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ZGH71J SCHEMBL24289352 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-6-oxohexyl]amino]isoindole-1,3-dione CN1CCN(C2CCN(C(=O)CCCCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)CC2)CC1 Degrader C29H40N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9QHGOZ SCHEMBL24290730 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-pyrimidin-2-ylpiperidin-1-yl)hexyl]amino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(NCCCCCC(=O)N4CCC(C5=NC=CC=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C28H32N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-QYW5SN SCHEMBL27090795 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-(3-quinoxalin-2-ylpyrrolidin-1-yl)piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL30875408 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCCC(=O)N4CCC(N5CCC(C6=NC7=CC=CC=C7N=C6)C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C36H41N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-182MK7 SCHEMBL24290738 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-[4-(2-methylbenzoyl)piperazin-1-yl]-6-oxohexyl]amino]isoindole-1,3-dione; SCHEMBL29591496 CC1=CC=CC=C1C(=O)N1CCN(C(=O)CCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)CC1 Degrader C31H35N5O6 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PFDGKF SCHEMBL24290271 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-pyridin-2-ylpiperidin-1-yl)hexyl]amino]isoindole-1,3-dione; SCHEMBL30875622 O=C1CCC(N2C(=O)C3=CC=C(NCCCCCC(=O)N4CCC(C5=CC=CC=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C29H33N5O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-Z5T8RY SCHEMBL27090915 3-[6-[2-[3-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-3-oxopropoxy]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29591604 O=C1CCC(N2CC3=C(/C=C\C(OCCOCCC(=O)N4CCC(N5C=C(C6=NC7=C(Br)C=CC=C7N=C6)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C34H34BrN7O6 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-X27M5L SCHEMBL24290731 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-pyridin-2-ylpiperazin-1-yl)hexyl]amino]isoindole-1,3-dione; SCHEMBL30875373 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCN(C5=CC=CC=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C28H32N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JF2ZC3 SCHEMBL24289342 6-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-6-oxohexanamide; SCHEMBL29590043 O=C1CCC(N2CC3=C(/C=C\C(NC(=O)CCCCC(=O)N4CCC(N5C=C(C6=NC7=C(Br)C=CC=C7N=C6)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C35H35BrN8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-D16PSV WO-2022073469-A1_GS-021 . O=C(CCCC(=O)N1CCC(N2C=C(C3=N/C4C(=CC=CC4Br)/N=C\3)C=N2)CC1)NCC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C35H37BrN8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-VI9J0P SCHEMBL24291554 N-[3-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-3-oxopropyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxy]acetamide; SCHEMBL29590692 O=C(COC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2)NCCC(=O)N1CCC(N2C=C(C3=N/C4=C(Br)C=CC=C4/N=C\3)C=N2)CC1 Degrader C34H33BrN8O6 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-53D4VU SCHEMBL24291558 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-[3-(1,2,3,4-tetrahydroquinoxalin-2-yl)pyrrolidin-1-yl]piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL30875490 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5CCC(C6CNC7=CC=CC=C7N6)C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C36H45N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-VJDWS9 SCHEMBL24291550 3-[7-[[2-[3-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]anilino]pyrimidin-4-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875374 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=NC(NC4=CC=CC(N5CCC(N6C=C(C7=NC8=C(Br)C=CC=C8N=C7)C=N6)CC5)=C4)=NC=C3)C2=O)C(=O)N1 Degrader C39H34BrN11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-61CT4M SCHEMBL27090879 3-[3-oxo-7-[[2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875401 O=C1CCC(N2CC3=C(C=CC=C3NC3=NC(NC4=CC=CC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=C4)=NC=C3)C2=O)C(=O)N1 Degrader C39H35N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-RBEFTY SCHEMBL27090919 3-[7-[[2-[4-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]anilino]pyrimidin-4-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875582 O=C1CCC(N2CC3=C(NC4=CC=NC(NC5=CC=C(N6CCC(N7C=C(C8=NC9=C(Br)C=CC=C9N=C8)C=N7)CC6)C=C5)=N4)C=CC=C3C2=O)C(=O)N1 Degrader C39H34BrN11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-IHDCLC SCHEMBL27090932 3-[3-oxo-7-[[2-[4-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875551 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=NC(NC4=CC=C(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)C=C4)=NC=C3)C2=O)C(=O)N1 Degrader C39H35N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KL7OZU SCHEMBL27091082 3-[7-[[2-[3-[[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]methyl]anilino]pyrimidin-4-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875420 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=NC(NC4=CC=CC(CN5CCC(N6C=C(C7=N/C8=C(Br)C=CC=C8/N=C\7)C=N6)CC5)=C4)=NC=C3)C2=O)C(=O)N1 Degrader C40H36BrN11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-2EIIVK SCHEMBL27090828 3-[3-oxo-7-[[2-[3-[[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]methyl]anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875304 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=NC(NC4=CC=CC(CN5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=C4)=NC=C3)C2=O)C(=O)N1 Degrader C40H37N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BN8UBI SCHEMBL27091055 3-[7-[[2-[4-[[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]methyl]anilino]pyrimidin-4-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875440 O=C1CCC(N2CC3=C(C=CC=C3NC3=NC(NC4=CC=C(CN5CCC(N6C=C(C7=NC8=C(Br)C=CC=C8N=C7)C=N6)CC5)C=C4)=NC=C3)C2=O)C(=O)N1 Degrader C40H36BrN11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LGXSZ0 SCHEMBL27090556 3-[3-oxo-7-[[2-[4-[[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]methyl]anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875274 O=C1CCC(N2CC3=C(C=CC=C3NC3=NC(NC4=CC=C(CN5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)C=C4)=NC=C3)C2=O)C(=O)N1 Degrader C40H37N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-L9VLHU SCHEMBL27091493 3-[7-[[2-[[2-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-2,3-dihydro-1H-inden-5-yl]amino]pyrimidin-4-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875319 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=NC(NC4=C/C=C5/CC(N6CCC(N7C=C(C8=N/C9=C(Br)C=CC=C9/N=C\8)C=N7)CC6)C/C5=C\4)=NC=C3)C2=O)C(=O)N1 Degrader C42H38BrN11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5QFRRF SCHEMBL24292114 3-[3-oxo-7-[[2-[[2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]-2,3-dihydro-1H-inden-5-yl]amino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875577 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=NC(NC4=CC=C5CC(N6CCC(N7C=C(C8=NC9=C\C=C/C=C\9N=C8)C=N7)CC6)CC5=C4)=NC=C3)C2=O)C(=O)N1 Degrader C42H39N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-M65WMR SCHEMBL24292062 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-[4-[4-(8-morpholin-4-ylquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]isoindole-1,3-dione; SCHEMBL30875328 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=NC7=C(N8CCOCC8)C=CC=C7N=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C39H43N9O6 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-FW6SQ3 WO-2022073469-A1_GS-035 . O=C1CCC(N2C(=O)C3=C(C=C(NCCCCCC(=O)N4CCC(N5C=C(/C6=N/C7=C(N8CCNCC8)C=CC=C7NC6)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C39H46N10O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-6ZB45Z SCHEMBL27091032 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-[4-[4-[8-(4-methylpiperazin-1-yl)quinoxalin-2-yl]pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]isoindole-1,3-dione; SCHEMBL29590205 CN1CCN(C2=C3/N=C(C4=CN(C5CCN(C(=O)CCCCCNC6=C/C7=C(\C=C/6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)N=C4)\C=N/C3=CC=C2)CC1 Degrader C40H46N10O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5YU71V SCHEMBL24292113 3-[6-[[6-[4-[4-(8-morpholin-4-ylquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875385 O=C1CCC(N2CC3=C(C=CC(NCCCCCC(=O)N4CCC(N5C=C(C6=N/C7=C(N8CCOCC8)C=CC=C7/N=C\6)C=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C39H45N9O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CU3SG8 SCHEMBL27091269 3-[3-oxo-6-[[6-oxo-6-[4-[4-(8-piperazin-1-ylquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]hexyl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875410 O=C1CCC(N2CC3=C(/C=C\C(NCCCCCC(=O)N4CCC(N5C=C(C6=N/C7=C(N8CCNCC8)C=CC=C7/N=C\6)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C39H46N10O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LLXDLI SCHEMBL24274144 N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-4-phenylbenzenesulfonamide\; SCHEMBL24274144 O=C1CCC(N2Cc3cc(NS(=O)(=O)c4ccc(-c5ccccc5)cc4)ccc3C2=O)C(=O)N1 Degrader C25H21N3O5S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-JM6XQY SCHEMBL27091382 3-[6-[[6-[4-[4-[8-(4-methylpiperazin-1-yl)quinoxalin-2-yl]pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875339 CN1CCN(C2=C3N=C(C4=CN(C5CCN(C(=O)CCCCCNC6=C/C7=C(\C=C/6)C(=O)N(C6CCC(=O)NC6=O)C7)CC5)N=C4)C=NC3=CC=C2)CC1 Degrader C40H48N10O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ZZXB0D SCHEMBL27091205 3-[6-[[6-[4-[4-[8-(oxan-4-yl)quinoxalin-2-yl]pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875587 O=C1CCC(N2CC3=C(/C=C\C(NCCCCCC(=O)N4CCC(N5C=C(C6=N/C7=C(C8CCOCC8)C=CC=C7/N=C\6)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C40H46N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-QBNTNS SCHEMBL27091437 3-[3-oxo-6-[[6-oxo-6-[4-[4-(8-piperidin-4-ylquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]hexyl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875310 O=C1CCC(N2CC3=C(/C=C\C(NCCCCCC(=O)N4CCC(N5C=C(C6=NC7=C(C8CCNCC8)C=CC=C7N=C6)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C40H47N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-EPN5FN SCHEMBL27091131 3-[6-[[6-[4-[4-[8-(1-methylpiperidin-4-yl)quinoxalin-2-yl]pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875657 CN1CCC(C2=C3/N=C(C4=CN(C5CCN(C(=O)CCCCCNC6=CC7=C(C=C6)C(=O)N(C6CCC(=O)NC6=O)C7)CC5)N=C4)\C=N/C3=CC=C2)CC1 Degrader C41H49N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4I2NWY SCHEMBL27091062 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-[4-[4-[8-(oxan-4-yl)quinoxalin-2-yl]pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]isoindole-1,3-dione; SCHEMBL30875316 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=N/C7=C(C8CCOCC8)C=CC=C7/N=C\6)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C40H44N8O6 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PUQI7G SCHEMBL27090974 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-[4-(8-piperidin-4-ylquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL30875306 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=N/C7=C(C8CCNCC8)C=CC=C7/N=C\6)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C40H45N9O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CGSB62 CHEMBL5084281 3-chloro-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-4-methylbenzenesulfonamide\; CHEMBL5084281; SCHEMBL24273917; BDBM669522; US20240132463, Compound 7; 3-chloro-N-(2-(2,6-dioxopiperidin-3- yl)-1,3-dioxoisoindolin-5-yl)-4- methylbenzenesulfonamide Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1Cl Degrader C20H16ClN3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-X8JJ19 SCHEMBL24289645 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-[4-[4-[8-(1-methylpiperidin-4-yl)quinoxalin-2-yl]pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]isoindole-1,3-dione; SCHEMBL29591131 CN1CCC(C2=C3/N=C(C4=CN(C5CCN(C(=O)CCCCCNC6=CC7=C(C=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)N=C4)\C=N/C3=CC=C2)CC1 Degrader C41H47N9O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OYIUTC SCHEMBL27090805 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-[4-[4-(4-methylpiperazin-1-yl)pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]isoindole-1,3-dione; SCHEMBL30875395 CN1CCN(C2=CN(C3CCN(C(=O)CCCCCNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)N=C2)CC1 Degrader C32H42N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LQJCXE SCHEMBL24289642 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-[4-(4-morpholin-4-ylpyrazol-1-yl)piperidin-1-yl]-6-oxohexyl]amino]isoindole-1,3-dione; SCHEMBL29590183 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(N6CCOCC6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C31H39N7O6 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-E73UG1 SCHEMBL24289667 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-(4-piperidin-1-ylpyrazol-1-yl)piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL29591897 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(N6CCCCC6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C32H41N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BCEBG6 SCHEMBL24289670 5-[[6-[4-(4-Cyclohexylpyrazol-1-yl)piperidin-1-yl]-6-oxohexyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6CCCCC6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C33H42N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-XP13T0 SCHEMBL24289582 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-(4-phenylpyrazol-1-yl)piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL30875458 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=CC=CC=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C33H36N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UEBON4 SCHEMBL24289658 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-(4-pyrimidin-2-ylpyrazol-1-yl)piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL29590415 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=NC=CC=N6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C31H34N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-D7UVST SCHEMBL24290155 5-[[6-[4-[4-(8-Bromoquinolin-2-yl)pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL29589597 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=N/C7=C(Br)C=CC=C7/C=C\6)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C36H36BrN7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HN0UTL SCHEMBL24289673 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-(4-pyridin-2-ylpyrazol-1-yl)piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL29589905 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=NC=CC=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C32H35N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5COJ8O WO-2022073469-A1_GS-054 . CC(F)(CCC(=O)NCC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2)C(=O)N1CCC(N2C=C(C3=NC4=C(Br)C=CC=C4N=C3)C=N2)CC1 Degrader C36H36BrFN8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-M5Y0GM SCHEMBL24290400 3-[6-[6-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-6-oxohexoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875313 O=C1CCC(N2CC3=C(/C=C\C(OCCCCCC(=O)N4CCC(N5C=C(C6=NC7=C(/C=C\C=C/7Br)N=C6)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C35H36BrN7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-AB7Z5C SCHEMBL24642825 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-4-(trifluoromethyl)benzenesulfonamide\; SCHEMBL24642825 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc(C(F)(F)F)cc4)cc3C2=O)C(=O)N1 Degrader C20H14F3N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-M6AIAI SCHEMBL27090536 4-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-N-[2-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]ethyl]-4-oxobutanamide; SCHEMBL30875292 O=C(CCC(=O)N1CCC(N2C=C(C3=NC4=C(Br)C=CC=C4N=C3)C=N2)CC1)NCCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C35H35BrN8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-VTUMUL SCHEMBL27090675 6-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-2,2-difluoro-6-oxohexanamide; SCHEMBL30875241 O=C1CCC(N2CC3=C(/C=C\C(NC(=O)C(F)(F)CCCC(=O)N4CCC(N5C=C(C6=N/C7=C(Br)C=CC=C7/N=C\6)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C35H33BrF2N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-39VDPE SCHEMBL27091063 5-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-N-methyl-5-oxopentanamide; SCHEMBL29590028 CN(CC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2)C(=O)CCCC(=O)N1CCC(N2C=C(C3=NC4=C(Br)C=CC=C4N=C3)C=N2)CC1 Degrader C36H37BrN8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-INDORN SCHEMBL24290414 5-[[6-[4-(8-Bromoquinoxalin-2-yl)pyrazol-1-yl]-6-oxohexyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875358 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCCC(=O)N4C=C(C5=N/C6=C(Br)C=CC=C6/N=C\5)C=N4)C=C3)C2=O)C(=O)N1 Degrader C30H26BrN7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-55UCEU SCHEMBL24291757 5-[[6-[4-(8-Bromoquinoxalin-2-yl)piperidin-1-yl]-6-oxohexyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(C5=CN=C6C=CC=C(Br)C6=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C32H33BrN6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-736TPG SCHEMBL27090759 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-pyrazol-1-ylphenyl)hexyl]amino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)C4=CC=C(N5C=CC=N5)C=C4)\C=C/3)C2=O)C(=O)N1 Degrader C28H27N5O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-0IICFL SCHEMBL24290662 5-[[6-[3-[4-(8-Bromoquinoxalin-2-yl)pyrazol-1-yl]azetidin-1-yl]-6-oxohexyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL29590353 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CC(N5C=C(C6=N/C7=C(Br)C=CC=C7/N=C\6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H31BrN8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PKZFIH SCHEMBL24290403 5-[[6-[4-[4-(Azetidin-1-yl)pyrazol-1-yl]piperidin-1-yl]-6-oxohexyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(N6CCC6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C30H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-WJXQEM SCHEMBL27091172 5-[[6-[4-(4-Cyclopropylpyrazol-1-yl)piperidin-1-yl]-6-oxohexyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6CC6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C30H36N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ICWOIE SCHEMBL27091056 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[3-(6-methylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione CC1=CC=CC(C2=NN(C3CC(CNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)C=C2)=N1 Degrader C27H26N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JA9C4O SCHEMBL27090728 5-[[3-[3-Cyclopropyl-4-(6-morpholin-4-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875434 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=NC7=CC=C(N8CCOCC8)C=C7N=C6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C36H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-O27VFZ SCHEMBL27090693 5-[[3-[3-Cyclopropyl-4-[7-(morpholin-4-ylmethyl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875615 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=NC7=CC(CN8CCOCC8)=CC=C7N=C6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C37H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-NL5NXS SCHEMBL24273921 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-1-phenylmethanesulfonamide\; SCHEMBL24273921 O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)Cc4ccccc4)cc3C2=O)C(=O)N1 Degrader C20H17N3O6S GSPT1 P15170 CRBN WO-2022066835-A1 TPD-80XO4K SCHEMBL27091109 5-[[3-[3-Cyclopropyl-4-[7-(piperazin-1-ylmethyl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875572 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=NC7=CC(CN8CCNCC8)=CC=C7N=C6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C37H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-59VO3R SCHEMBL24292072 5-[[3-[3-Cyclopropyl-4-(6-ethylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875363 CCC1=CC=CC(C2=CN([C@H]3C[C@H](CNC4=CC5=C(C=C4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2C2CC2)=N1 Degrader C31H32N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-FQX8HG SCHEMBL24291464 5-[3-[3-[4-(3-Chloropyridin-2-yl)-3-cyclopropylpyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091374; SCHEMBL30875312 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=C(Cl)C=CC=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C31H31ClN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-78S72J SCHEMBL24290079 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[4-(6-methylpyridin-2-yl)-3-(oxan-4-yl)pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione; SCHEMBL24290199; SCHEMBL27091177 CC1=CC=CC(C2=CN([C@H]3C[C@H](CNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2C2CCOCC2)=N1 Degrader C32H34N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-H66EBD SCHEMBL27090681 3-[6-[[2-[[2-[4-[4-(8-bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-2,3-dihydro-1H-inden-5-yl]amino]pyrimidin-4-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875415 O=C1CCC(N2CC3=C\C(NC4=NC(NC5=C/C6=C(\C=C/5)CC(N5CCC(N7C=C(C8=NC9=C(Br)C=CC=C9N=C8)C=N7)CC5)C6)=NC=C4)=C/C=C\3C2=O)C(=O)N1 Degrader C42H38BrN11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-WPRLB1 SCHEMBL27090913 3-[3-oxo-6-[[2-[[2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]-2,3-dihydro-1H-inden-5-yl]amino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875446 O=C1CCC(N2CC3=C\C(NC4=NC(NC5=C/C6=C(\C=C/5)CC(N5CCC(N7C=C(C8=NC9=CC=CC=C9N=C8)C=N7)CC5)C6)=NC=C4)=C/C=C\3C2=O)C(=O)N1 Degrader C42H39N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UNJOZQ SCHEMBL27090995 3-[3-oxo-7-[[2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]pyrrolidin-1-yl]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875457 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=NC(N4CCC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)C4)=NC=C3)C2=O)C(=O)N1 Degrader C37H37N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-7RY16W SCHEMBL27091104 3-[3-oxo-7-[[2-[3-(4-phenylpiperidin-1-yl)anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875405 O=C1CCC(N2CC3=C(NC4=NC(NC5=CC=CC(N6CCC(C7=CC=CC=C7)CC6)=C5)=NC=C4)C=CC=C3C2=O)C(=O)N1 Degrader C34H33N7O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-353XLM SCHEMBL24290080 3-[3-oxo-7-[[2-[3-(4-pyridin-2-ylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875451 O=C1CCC(N2CC3=C(NC4=NC(NC5=CC=CC(N6CCN(C7=NC=CC=C7)CC6)=C5)=NC=C4)C=CC=C3C2=O)C(=O)N1 Degrader C32H31N9O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-FI523I SCHEMBL24290083 3-[3-oxo-7-[[2-[3-(4-pyridin-2-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875524 O=C1CCC(N2CC3=C(NC4=NC(NC5=CC=CC(N6CCC(C7=CC=CC=N7)CC6)=C5)=NC=C4)C=CC=C3C2=O)C(=O)N1 Degrader C33H32N8O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-G4SKXM SCHEMBL27090561 3-[3-oxo-7-[[2-[3-(4-pyrimidin-2-ylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875470 O=C1CCC(N2CC3=C(NC4=NC(NC5=CC=CC(N6CCN(C7=NC=CC=N7)CC6)=C5)=NC=C4)C=CC=C3C2=O)C(=O)N1 Degrader C31H30N10O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-XOMMCV SCHEMBL27090698 3-[3-oxo-7-[[2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidine-1-carbonyl]anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875550 O=C1CCC(N2CC3=C(NC4=CC=NC(NC5=CC=CC(C(=O)N6CCC(N7C=C(C8=NC9=CC=CC=C9N=C8)C=N7)CC6)=C5)=N4)C=CC=C3C2=O)C(=O)N1 Degrader C40H35N11O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PVGUQX SCHEMBL24290164 3-[3-oxo-7-[[2-[3-(4-pyridin-2-ylpiperazine-1-carbonyl)anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875323 O=C1CCC(N2CC3=C(NC4=CC=NC(NC5=CC=CC(C(=O)N6CCN(C7=CC=CC=N7)CC6)=C5)=N4)C=CC=C3C2=O)C(=O)N1 Degrader C33H31N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-8F9WF1 SCHEMBL27090894 3-[3-oxo-7-[[2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29590766 O=C1CCC(N2CC3=C(NC4=NC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=NC=C4)C=CC=C3C2=O)C(=O)N1 Degrader C33H30N10O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-F5GWLO WO-2022073469-A1_GS-082 . O=C(CC1CC(N2CCC(N3C=C(C4=N/C5=C(C=CC=C5)/N=C\4)C=N3)CC2)C1)NCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)CC2C1 Degrader C36H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-Q9B173 SCHEMBL27090669 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]cyclopropyl]acetamide; SCHEMBL30875378 O=C(CC1CC1N1CCC(N2C=C(C3=NC4=CC=CC=C4N=C3)C=N2)CC1)NCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)CC2=C1 Degrader C35H36N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-AOIRL6 SCHEMBL27090889 3-[3-oxo-7-[[2-[3-(4-quinoxalin-2-ylpyrazol-1-yl)anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875393 O=C1CCC(N2CC3=C(NC4=NC(NC5=CC=CC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)=C5)=NC=C4)C=CC=C3C2=O)C(=O)N1 Degrader C34H26N10O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HASP97 SCHEMBL27091064 3-[3-oxo-7-[[2-[[3-oxo-3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]propyl]amino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875383 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=NC(NCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)=NC=C3)C2=O)C(=O)N1 Degrader C36H35N11O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-F0ZQYD SCHEMBL27090856 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]cyclohexyl]acetamide; SCHEMBL30875338 O=C(CC1CCCC(N2CCC(N3C=C(C4=NC5=CC=CC=C5N=C4)C=N3)CC2)C1)NCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)CC2=C1 Degrader C38H42N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-S3F2L3 SCHEMBL27091149 N-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]anilino]acetamide O=C(CNC1=CC(N2CCC(N3C=C(C4=NC5=CC=CC=C5N=C4)C=N3)CC2)=CC=C1)NCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CS1 Degrader C36H35N9O4S GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HIHBMD SCHEMBL27090598 3-[3-oxo-7-[[2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]propylamino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875548 O=C1CCC(N2CC3=C(NC4=NC(NCCCN5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=NC=C4)C=CC=C3C2=O)C(=O)N1 Degrader C36H37N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-TV97VM SCHEMBL27090742 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[4-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]cyclohexyl]acetamide; SCHEMBL30875569 O=C(CC1CCC(N2CCC(N3C=C(C4=NC5=CC=CC=C5N=C4)C=N3)CC2)CC1)NCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)CC2=C1 Degrader C38H42N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-GFON3V SCHEMBL27090900 3-[3-oxo-7-[[6-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]anilino]pyridin-2-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875372 O=C1CCC(N2CC3=C(NC4=NC(NC5=CC=CC(N6CCC(N7C=C(C8=NC9=CC=CC=C9N=C8)C=N7)CC6)=C5)=CC=C4)C=CC=C3C2=O)C(=O)N1 Degrader C40H36N10O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HHDSRW SCHEMBL27091385 3-[3-oxo-7-[[2-[[2-oxo-2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]ethyl]amino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875585 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=CC=NC(NCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)=N3)C2=O)C(=O)N1 Degrader C35H33N11O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OW6OXK SCHEMBL27090667 3-[3-oxo-7-[[2-[[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]cyclopentyl]amino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875379 O=C1CCC(N2CC3=C(NC4=NC(NC5CCC(N6CCC(N7C=C(C8=NC9=CC=CC=C9N=C8)C=N7)CC6)C5)=NC=C4)C=CC=C3C2=O)C(=O)N1 Degrader C38H39N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-QX9BT6 SCHEMBL27090836 1-[[5-(2,6-dioxopiperidin-3-yl)-6-oxo-4H-thieno[3,4-c]pyrrol-3-yl]methyl]-3-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]phenyl]urea O=C1CCC(N2CC3=C(CNC(=O)NC4=CC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=CC=C4)SC=C3C2=O)C(=O)N1 Degrader C35H33N9O4S GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LEA0KR SCHEMBL24290311 3-[3-oxo-7-[[2-[3-(4-piperidin-1-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875391 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3=NC(NC4=CC=CC(N5CCC(N6CCCCC6)CC5)=C4)=NC=C3)C2=O)C(=O)N1 Degrader C33H38N8O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-DM5SV4 SCHEMBL24290316 3-[3-oxo-5-[6-oxo-6-(4-phenylpiperidin-1-yl)hexyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29590065 O=C1CCC(N2CC3=C(C=C(CCCCCC(=O)N4CCC(C5=CC=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C30H35N3O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9YOJ2T SCHEMBL27090963 3-[3-oxo-5-[7-oxo-7-(4-pyridin-2-ylpiperazin-1-yl)heptyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29589700 O=C1CCC(N2CC3=CC=C(CCCCCCC(=O)N4CCN(C5=NC=CC=C5)CC4)C=C3C2=O)C(=O)N1 Degrader C29H35N5O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-92LXPC SCHEMBL27090765 3-[3-oxo-5-[7-oxo-7-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]heptyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875477 O=C1CCC(N2CC3=C\C=C(CCCCCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)/C=C\3C2=O)C(=O)N1 Degrader C36H39N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PP2NPL SCHEMBL24290321 3-[3-oxo-5-[7-oxo-7-[4-(4-quinolin-2-ylpyrazol-1-yl)piperidin-1-yl]heptyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC=C(CCCCCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7C=C6)C=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C37H40N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-RA3WOK SCHEMBL24290322 3-[3-oxo-5-[7-oxo-7-(4-phenylpiperidin-1-yl)heptyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC=C(CCCCCCC(=O)N4CCC(C5=CC=CC=C5)CC4)C=C3C2=O)C(=O)N1 Degrader C31H37N3O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OUYASE SCHEMBL27090628 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)cyclohexyl]ethylamino]isoindole-1,3-dione; SCHEMBL29589642 O=C1CCC(N2C(=O)C3=CC=C(NCCC4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-A0V5WP SCHEMBL24290768 3-[3-oxo-5-[6-oxo-6-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]hexyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875308 O=C1CCC(N2CC3=C(/C=C(CCCCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C35H37N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UDDWQF SCHEMBL27091075 3-[3-oxo-5-[6-oxo-6-[4-(4-quinolin-2-ylpyrazol-1-yl)piperidin-1-yl]hexyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875464 O=C1CCC(N2CC3=C(/C=C(CCCCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7C=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C36H38N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KT1ESX SCHEMBL24290756 3-[3-oxo-5-[6-oxo-6-(4-pyridin-2-ylpiperazin-1-yl)hexyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29590555 O=C1CCC(N2CC3=C(/C=C(CCCCCC(=O)N4CCN(C5=CC=CC=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C28H33N5O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4ER6PS SCHEMBL24290741 3-[3-oxo-5-[6-oxo-6-(4-pyridin-2-ylpiperidin-1-yl)hexyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29589806 O=C1CCC(N2CC3=C(/C=C(CCCCCC(=O)N4CCC(C5=CC=CC=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C29H34N4O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-W9QKJA SCHEMBL24290759 3-[3-oxo-5-[7-(4-quinoxalin-2-ylpyrazol-1-yl)heptyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC=C(CCCCCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)C=C3C2=O)C(=O)N1 Degrader C31H32N6O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-MZX5FM SCHEMBL24290760 3-[3-oxo-5-[6-(4-quinoxalin-2-ylpyrazol-1-yl)hexyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC=C(CCCCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)C=C3C2=O)C(=O)N1 Degrader C30H30N6O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-47HZSB WO-2022073469-A1_GS-107 . O=C1CCC(N2C(=O)C3=CC=C(NCCCC4CC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-GKVHOR SCHEMBL27090818 3-[3-oxo-7-[[4-[[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]methyl]phenyl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875471 O=C1CCC(N2CC3=C(OCC4=CC=C(CN5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)C=C4)C=CC=C3C2=O)C(=O)N1 Degrader C37H35N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ZD09I1 SCHEMBL24288830 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[2-(4-quinoxalin-2-ylpyrazol-1-yl)cyclopropyl]acetamide O=C(CC1CC1N1C=C(C2=NC3=CC=CC=C3N=C2)C=N1)NCC1=C/C=C2/C(=O)N(C3CCC(=O)NC3=O)C/C2=C\1 Degrader C30H27N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-QKNC7B SCHEMBL27090622 3-[3-oxo-7-[[3-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]anilino]cyclohexyl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875546 O=C1CCC(N2CC3=C(/C=C\C=C/3NC3CCCC(NC4=CC=CC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=C4)C3)C2=O)C(=O)N1 Degrader C41H43N9O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-E2Y5FM SCHEMBL24288803 3-[3-oxo-5-[7-oxo-7-(4-pyridin-2-ylpiperidin-1-yl)heptyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC=C(CCCCCCC(=O)N4CCC(C5=NC=CC=C5)CC4)C=C3C2=O)C(=O)N1 Degrader C30H36N4O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5MAFCS SCHEMBL24289027 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-quinoxalin-2-ylpyrazol-1-yl)cyclohexyl]propylamino]isoindole-1,3-dione; SCHEMBL29590007 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCC4CCCC(N5C=C(C6=CN=C7C=CC=CC7=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YUH2DR SCHEMBL24289615 3-[5-[6-[4-(3-chlorophenyl)piperidin-1-yl]-6-oxohexyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29590890 O=C1CCC(N2CC3=C/C=C(CCCCCC(=O)N4CCC(C5=CC(Cl)=CC=C5)CC4)\C=C\3C2=O)C(=O)N1 Degrader C30H34ClN3O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-A8L8MT SCHEMBL27090620 3-[5-[6-[4-(4-chlorophenyl)piperidin-1-yl]-6-oxohexyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29590736 O=C1CCC(N2CC3=C/C=C(CCCCCC(=O)N4CCC(C5=CC=C(Cl)C=C5)CC4)\C=C\3C2=O)C(=O)N1 Degrader C30H34ClN3O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9YU0WS SCHEMBL24289617 3-[5-[7-[4-(3-chlorophenyl)piperidin-1-yl]-7-oxoheptyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29589531 O=C1CCC(N2CC3=CC=C(CCCCCCC(=O)N4CCC(C5=CC(Cl)=CC=C5)CC4)C=C3C2=O)C(=O)N1 Degrader C31H36ClN3O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-MUIJCT SCHEMBL24289614 3-[5-[7-[4-(4-chlorophenyl)piperidin-1-yl]-7-oxoheptyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC=C(CCCCCCC(=O)N4CCC(C5=CC=C(Cl)C=C5)CC4)C=C3C2=O)C(=O)N1 Degrader C31H36ClN3O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-C851LE SCHEMBL24289624 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)phenyl]ethylamino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(NCCC4=CC=C(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C=C4)C=C3C2=O)C(=O)N1 Degrader C32H25N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-8AIXS5 SCHEMBL27090988 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[[2-(4-quinoxalin-2-ylpyrazol-1-yl)cyclopropyl]methylamino]ethylamino]isoindole-1,3-dione; SCHEMBL30875262 O=C1CCC(N2C(=O)C3=CC=C(NCCNCC4CC4N4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)C=C3C2=O)C(=O)N1 Degrader C30H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LFX50U SCHEMBL27090791 3-[3-oxo-7-[[3-[[2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]pyrimidin-4-yl]amino]cyclohexyl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875353 O=C1CCC(N2CC3=C(NC4CCCC(NC5=CC=NC(N6CCC(N7C=C(C8=NC9=CC=CC=C9N=C8)C=N7)CC6)=N5)C4)C=CC=C3C2=O)C(=O)N1 Degrader C39H41N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LNC08J WO-2022073469-A1_GS-120 . O=C1CCC(N2CC3/C=C(CNC(=O)C45CC6(C(=O)N7CCC(N8C=C(C9=NC%10=CC=CC=C%10N=C9)C=N8)CC7)CC46C5)\C=C/C3C2=O)C(=O)N1 Degrader C38H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-L9L9OZ SCHEMBL27090907 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidine-1-carbonyl]-1-bicyclo[1.1.1]pentanyl]acetamide; SCHEMBL29590875 O=C(CC12CC(C(=O)N3CCC(N4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)CC3)(C1)C2)NCC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C38H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-N7LN1T SCHEMBL24342088 2-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24342088 O=C(Cc1cn2cc(F)ccc2n1)Nc1ncc(C(F)(F)F)s1 Degrader C13H8F4N4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-PSM9SO SCHEMBL27091200 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[4-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]phenyl]acetamide; SCHEMBL30875254 O=C(CC1=CC=C(N2CCC(N3C=C(C4=NC5=CC=CC=C5N=C4)C=N3)CC2)C=C1)NCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)CC2=C1 Degrader C38H36N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-6D82WR SCHEMBL24290707 2-(2,6-Dioxopiperidin-3-yl)-5-[5-[1-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]cyclopropyl]pentylamino]isoindole-1,3-dione; SCHEMBL30875307 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC4(N5CCC(N6C=C(C7=NC8=C\C=C/C=C\8N=C7)C=N6)CC5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C37H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-6ZBLOZ SCHEMBL24290686 2-(2,6-Dioxopiperidin-3-yl)-5-[4-[1-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]cyclopropyl]butylamino]isoindole-1,3-dione; SCHEMBL30875476 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCC4(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)CC4)C=C3)C2=O)C(=O)N1 Degrader C36H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-K79F5F SCHEMBL27090603 3-[3-oxo-7-[[3-[[4-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]pyrimidin-2-yl]amino]cyclohexyl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875516 O=C1CCC(N2CC3=C(NC4CCCC(NC5=NC=CC(N6CCC(N7C=C(C8=NC9=CC=CC=C9N=C8)C=N7)CC6)=N5)C4)C=CC=C3C2=O)C(=O)N1 Degrader C39H41N11O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-14T5B5 SCHEMBL24290696 3-[3-oxo-6-[5-[1-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]cyclopropyl]pentylamino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875542 O=C1CCC(N2CC3=C(/C=C\C(NCCCCCC4(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)CC4)=C/3)C2=O)C(=O)N1 Degrader C37H42N8O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-FVD80Q WO-2022073469-A1_GS-127 . CC(CCCCCCC1=CC=C2CN(C3CCC(=O)NC3=O)C(=O)C2=C1)N1C=C(C2=NC3=CC=CC=C3N=C2)C=N1 Degrader C32H34N6O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ZXHV9W SCHEMBL27090634 3-[3-oxo-5-[6-(4-quinoxalin-2-ylpyrazol-1-yl)hexylamino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29589466 O=C1CCC(N2CC3=C(C=C(NCCCCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)C=C3)C2=O)C(=O)N1 Degrader C30H31N7O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-GBF5D9 WO-2022073469-A1_GS-129 . O=C1CCC(N2C(=O)C3C=CC(NCCCCS(=O)(=O)N4CCC(N5C=C(C6=N/C7=CC=CC=C7/N=C\6)C=N5)CC4)=CC3C2=O)C(=O)N1 Degrader C33H36N8O6S GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CA9QXP SCHEMBL27090903 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]-1-bicyclo[1.1.1]pentanyl]acetamide; SCHEMBL29590527 O=C(CC12CC(N3CCC(N4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)CC3)(C1)C2)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C37H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5V0YPR SCHEMBL27090809 3-[3-oxo-5-[3-[3-(4-quinoxalin-2-ylpyrazol-1-yl)cyclobutyl]propylamino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29589567 O=C1CCC(N2CC3=CC=C(NCCCC4CC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C31H31N7O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OIOUNF SCHEMBL24342052 2-(8-methylimidazo[1,2-a]pyridin-3-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24342052 Cc1cccn2c(CC(=O)Nc3ncc(C(F)(F)F)s3)cnc12 Degrader C14H11F3N4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-RUE0G8 SCHEMBL24289723 N-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]propyl]-4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidine-1-carboxamide O=C1CCC(N2C(=O)C3=CC=C(NCCCNC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C33H33N9O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ANF8V6 SCHEMBL24289720 3-[3-oxo-7-[[1-[[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]phenyl]methyl]piperidin-3-yl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(NC4CCCN(CC5=CC(N6CCC(N7C=C(C8=NC9=CC=CC=C9N=C8)C=N7)CC6)=CC=C5)C4)/C=C\C=C\3C2=O)C(=O)N1 Degrader C41H43N9O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5LMDFC SCHEMBL24289725 3-[5-[7-[4-(3-methylquinoxalin-2-yl)pyrazol-1-yl]heptyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29589532 CC1=NC2=CC=CC=C2N=C1C1=CN(CCCCCCCC2=CC=C3CN(C4CCC(=O)NC4=O)C(=O)C3=C2)N=C1 Degrader C32H34N6O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LJADVL SCHEMBL24288836 3-[7-[[3-[3-[4-(3-chlorophenyl)piperidin-1-yl]anilino]cyclohexyl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875606 O=C1CCC(N2CC3=C(NC4CCCC(NC5=CC=CC(N6CCC(C7=CC(Cl)=CC=C7)CC6)=C5)C4)C=CC=C3C2=O)C(=O)N1 Degrader C36H40ClN5O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-SBCRCW SCHEMBL27090878 2-(2,6-Dioxopiperidin-3-yl)-5-[[5-oxo-5-[3-(4-quinoxalin-2-ylpyrazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]pentyl]amino]isoindole-1,3-dione; SCHEMBL29589707 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCC(=O)N4C5CCC4CC(N4C=C(C6=NC7=CC=CC=C7N=C6)C=N4)C5)C=C3)C2=O)C(=O)N1 Degrader C36H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-0SEAZ8 WO-2022073469-A1_GS-137 . O=C1CCC(N2CC3=C(C=CC(NCCCCC4(N5CCC(N6C=C(C7=NC8CC=CC=C8N=C7)C=N6)CC5)CC4)=C3)C2=O)C(=O)N1 Degrader C36H42N8O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-XMKN9P WO-2022073469-A1_GS-138 . C=C1C2=C(C=CC(NCCCC(C)C(=O)N3CCC(N4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)CC3)=C2)C(=O)N1C1CCC(=O)NC1=O Degrader C36H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-RH2FFM SCHEMBL24289717 5-[[4,4-Dimethyl-5-oxo-5-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]pentyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC(C)(CCCNC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)N1CCC(N2C=C(C3=NC4=CC=CC=C4N=C3)C=N2)CC1 Degrader C36H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4HQOZ7 SCHEMBL27091169 3-[3-oxo-6-[3-[3-(4-quinoxalin-2-ylpyrazol-1-yl)cyclobutyl]propylamino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875336 O=C1CCC(N2CC3=CC(NCCCC4CC(N5C=C(C6=NC7=C/C=C\C=C\7N=C6)C=N5)C4)=CC=C3C2=O)C(=O)N1 Degrader C31H31N7O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-AWV5FK SCHEMBL24341143 2-(8-methylimidazo[1,2-a]pyridin-2-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24341143 Cc1cccn2cc(CC(=O)Nc3ncc(C(F)(F)F)s3)nc12 Degrader C14H11F3N4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-69N22M SCHEMBL24341141 2-(6,8-dichloroimidazo[1,2-a]pyridin-2-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24341141 O=C(Cc1cn2cc(Cl)cc(Cl)c2n1)Nc1ncc(C(F)(F)F)s1 Degrader C13H7Cl2F3N4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-PBGLY3 SCHEMBL27091408 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[1-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidine-1-carbonyl]cyclopropyl]propylamino]isoindole-1,3-dione; SCHEMBL30875320 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCC4(C(=O)N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C36H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4N5UXP WO-2022073469-A1_GS-142 . O=C1CCC(N2CC3/C(=C\C=C/C3NC3CCCC(CCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)C3)C2=O)C(=O)N1 Degrader C34H39N7O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-22IC2R SCHEMBL24341138 2-(6-bromo-8-methoxyimidazo[1,2-a]pyridin-2-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24341138 COc1cc(Br)cn2cc(CC(=O)Nc3ncc(C(F)(F)F)s3)nc12 Degrader C14H10BrF3N4O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-ZNFVW9 WO-2022073469-A1_GS-143 . C=C1C2=C(/C=C\C(NCCCCC(=O)N3[C@H](C)CC(N4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)C[C@@H]3C)=C/2)C(=O)N1C1CCC(=O)NC1=O Degrader C37H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4QFLY5 WO-2022073469-A1_GS-144 . O=C1CCC(N2C(=O)C3=CC=C(NC45CC(C(=O)N6CCC(N7C=C(C8=NC9=CC=CC=C9N=C8)C=N7)CC6)(C4)C5)C=C3C2=O)C(=O)N1 Degrader C35H32N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-W0OT8W SCHEMBL24290752 5-[[4,4-Difluoro-5-oxo-5-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]pentyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(NCCCC(F)(F)C(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C34H32F2N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-J26IKL SCHEMBL27090880 5-[6-(3,5-Dimethyl-4-pyrazin-2-ylpyrazol-1-yl)hexylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL29589565 CC1=NN(CCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C1C1=NC=CN=C1 Degrader C28H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-2F9YXK SCHEMBL24289462 2-(2,6-Dioxopiperidin-3-yl)-5-[[5-oxo-5-(4-phenylpiperidin-1-yl)pentyl]amino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C\C(NCCCCC(=O)N4CCC(C5=CC=CC=C5)CC4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H32N4O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-T43D00 SCHEMBL27091190 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-oxo-4-(4-phenylpiperidin-1-yl)butyl]amino]isoindole-1,3-dione; SCHEMBL30875279 O=C1CCC(N2C(=O)C3=CC=C(NCCCC(=O)N4CCC(C5=CC=CC=C5)CC4)C=C3C2=O)C(=O)N1 Degrader C28H30N4O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UE2OR8 WO-2022073469-A1_GS-149 . O=C1CCC(N2C(=O)C3/C=C\C(NCCNC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)=C/C3C2=O)C(=O)N1 Degrader C32H33N9O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-QP51YF SCHEMBL24290757 5-[6-(3,5-Dimethyl-4-pyrimidin-2-ylpyrazol-1-yl)hexylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL29589512 CC1=NN(CCCCCCNC2=C/C=C3/C(=O)N(C4CCC(=O)NC4=O)C(=O)/C3=C\2)C(C)=C1C1=NC=CC=N1 Degrader C28H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OKXSYU SCHEMBL24290745 5-[6-(3,5-Dimethyl-4-quinazolin-2-ylpyrazol-1-yl)hexylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL29589996 CC1=NN(CCCCCCNC2=C/C=C3/C(=O)N(C4CCC(=O)NC4=O)C(=O)/C3=C\2)C(C)=C1C1=N/C2=C(C=CC=C2)/C=N\1 Degrader C32H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-EW75SA SCHEMBL27090713 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]phenyl]ethylamino]isoindole-1,3-dione; SCHEMBL29589646 O=C1CCC(N2C(=O)C3=C(C=C(NCCC4=CC=CC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=C4)C=C3)C2=O)C(=O)N1 Degrader C37H34N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-2ECBND SCHEMBL24290762 2-(2,6-Dioxopiperidin-3-yl)-5-[[5-oxo-5-[7-(4-quinoxalin-2-ylpyrazol-1-yl)-4-azaspiro[2.5]octan-4-yl]pentyl]amino]isoindole-1,3-dione; SCHEMBL29589551 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC45CC5)C=C3)C2=O)C(=O)N1 Degrader C36H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-71OM4I WO-2022073469-A1_GS-154 . O=C1CCC(N2CC3=C(NC4CCCC(CCCC(=O)N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)C4)C=CCC3C2=O)C(=O)N1 Degrader C39H46N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-D5IBFV WO-2022073469-A1_GS-155 . C=C1NC(=O)CCC1N1C(=O)C2=CC=C(NCC3CCC(CN4C=C(C5=N/C6=C(C=CC=C6)/N=C\5)C=N4)CC3)C=C2C1=O Degrader C33H33N7O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9TRM8L SCHEMBL27090560 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(8-fluoroquinoxalin-2-yl)-3,5-dimethylpyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL29590506 CC1=NN(C2CC(CCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C2)C(C)=C1C1=NC2=C(F)C=CC=C2N=C1 Degrader C33H32FN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UDWRV8 SCHEMBL29059913 4-[4-[5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]-3-fluorobenzonitrile\; SCHEMBL29059913 N#Cc1ccc(N2CCN(C3CCc4cc(COc5cccc6c5CN([C@H]5CCC(=O)NC5=O)C6=O)ccc43)CC2)c(F)c1 Degrader C34H32FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022148358-A1 TPD-4KDVBQ SCHEMBL27091425 3-[3-oxo-7-[[3-[3-(4-quinoxalin-2-ylpyrazol-1-yl)propyl]cyclohexyl]amino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29589559 O=C1CCC(N2CC3=C(NC4CCCC(CCCN5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)C=CC=C3C2=O)C(=O)N1 Degrader C33H35N7O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-NR7LM8 SCHEMBL27090682 3-[3-oxo-5-[4-oxo-4-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]butyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875540 O=C1CCC(N2CC3=CC=C(CCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C33H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-58D5P1 SCHEMBL27090735 3-[3-oxo-5-[4-oxo-4-[4-(4-quinolin-2-ylpyrazol-1-yl)piperidin-1-yl]butyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875453 O=C1CCC(N2CC3=CC=C(CCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7C=C6)C=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C34H34N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-NIRYXY WO2022148358-A1_4-1 4-[4-[(1S)-5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]-3-fluorobenzonitrile N#Cc1ccc(N2CCN([C@H]3CCc4cc(COc5cccc6c5CN([C@H]5CCC(=O)NC5=O)C6=O)ccc43)CC2)c(F)c1 Degrader C34H32FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022148358-A1 TPD-GK6HM6 SCHEMBL27091295 3-[3-oxo-5-[5-oxo-5-[4-(4-quinolin-2-ylpyrazol-1-yl)piperidin-1-yl]pentyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875350 O=C1CCC(N2CC3=C(C=C(CCCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7C=C6)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C35H36N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-94I2K5 WO2022148358-A1_4-2 4-[4-[(1R)-5-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]-3-fluorobenzonitrile N#Cc1ccc(N2CCN([C@@H]3CCc4cc(COc5cccc6c5CN([C@H]5CCC(=O)NC5=O)C6=O)ccc43)CC2)c(F)c1 Degrader C34H32FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022148358-A1 TPD-840JLR SCHEMBL24291459 3-[3-oxo-5-[5-oxo-5-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]pentyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875370 O=C1CCC(N2CC3=C(/C=C(CCCCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C34H35N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-3GTI1H SCHEMBL24291461 3-[3-oxo-6-[[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]phenyl]methylamino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29589803 O=C1CCC(N2CC3=C(/C=C\C(NCC4=CC=CC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=C4)=C/3)C2=O)C(=O)N1 Degrader C36H34N8O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-7B0RR6 SCHEMBL24291467 3-[1-[6-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]hexyl]pyrazol-4-yl]quinoxaline-6-carbonitrile; SCHEMBL29590781 N#CC1=CC=C2N=CC(C3=CN(CCCCCCNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C3)=NC2=C1 Degrader C31H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-7VVNUU SCHEMBL27091003 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(8-fluoroquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL29591342 O=C1CCC(N2C(=O)C3=CC=C(NCCCC4CC(N5C=C(C6=NC7=C(F)C=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C31H28FN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UHUDHA SCHEMBL24290629 3-[1-[6-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]hexyl]pyrazol-4-yl]quinoxaline-5-carbonitrile; SCHEMBL29589605 N#CC1=C2/N=C(C3=CN(CCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)N=C3)\C=N/C2=CC=C1 Degrader C31H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-GDX4SV SCHEMBL24291468 3-[1-[6-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]hexyl]-3,5-dimethylpyrazol-4-yl]quinoxaline-5-carbonitrile; SCHEMBL29590020 CC1=NN(CCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C1C1=NC2=C(C#N)C=CC=C2N=C1 Degrader C33H32N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-3LRQL6 SCHEMBL27091057 5-[3-[3-(3,5-Dimethyl-4-quinoxalin-2-ylpyrazol-1-yl)cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CC1=NN(C2CC(CCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C2)C(C)=C1C1=NC2=CC=CC=C2N=C1 Degrader C33H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JHFDEV WO-2022073469-A1_GS-168 . CC1=NN([C@H]2C[C@@H](CCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C2)C=C1C1=NC2=CC=CC=C2N=C1 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4ED3AD WO-2022073469-A1_GS-169 . CC1=C(C2=NC3=CC=CC=C3N=C2)C=NN1C1CC(CCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C1 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-SGNIYM WO-2022073469-A1_GS-170 . CC1=C(C2=NC3=CC=CC=C3N=C2)C=NN1[C@H]1C[C@H](CCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C1 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-2YP6AV WO-2022073469-A1_GS-171 . CC1=NN([C@H]2C[C@H](CCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C2)C=C1C1=NC2=CC=CC=C2N=C1 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-G4ZIZR SCHEMBL27090695 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[7-(4-methylpiperazin-1-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL30875616 CN1CCN(C2=CC=C3N=CC(C4=CN(C5CC(CCCNC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)N=C4)=NC3=C2)CC1 Degrader C36H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-0QFCJN WO-2022073469-A1_GS-173 . O=C1CCC(N2C(=O)C3=CC=C(NCCCC4CC(N5C=C(C6=NC7=CC(N8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C35H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-FM08J6 WO-2022073469-A1_GS-175 . N#CC1=CC=C2N=CC(C3=CN(C4CC(CCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)N=C3)=NC2=C1 Degrader C32H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-28LZ47 WO-2022073469-A1_GS-176 . O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UT3PQI WO-2022073469-A1_GS-177 . O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UGYR3S WO-2022073469-A1_GS-178 . O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@H](N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C29H25N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-J6TITQ WO-2022073469-A1_GS-179 . O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@@H](N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C29H25N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4TTNJE WO-2022073469-A1_GS-180 . O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@H](N5C=C(C6=NC7=CC(C8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-K8HYMW WO-2022073469-A1_GS-181 . O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(C8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C36H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4VAYS9 WO-2022073469-A1_GS-182 . O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(C8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C36H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4580MD SCHEMBL27091143 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-[2-(4-quinoxalin-2-ylpyrazol-1-yl)ethyl]cyclohexyl]amino]isoindole-1,3-dione; SCHEMBL29589508 O=C1CCC(N2C(=O)C3=C\C(NC4CCC(CCN5C=C(C6=N/C7=C(C=CC=C7)/N=C\6)C=N5)CC4)=C/C=C\3C2=O)C(=O)N1 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ONKODU SCHEMBL27091087 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-[3-(4-quinoxalin-2-ylpyrazol-1-yl)propyl]cyclohexyl]amino]isoindole-1,3-dione; SCHEMBL29589800 O=C1CCC(N2C(=O)C3=C(/C=C(NC4CCC(CCCN5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C33H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YQNJKT WO-2022073469-A1_GS-185 . CN1CCN(C2=CC=C3N=CC(C4=CN([C@H]5C[C@H](CNC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)N=C4)=NC3=C2)CC1 Degrader C34H35N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-1W68FA WO-2022073469-A1_GS-186 . O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(N8CCNCC8)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C33H33N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JOWMCX WO-2022073469-A1_GS-187 . O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@H](N5C=C(C6=NC7=CC(N8CCNCC8)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C33H33N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-XG7SF9 WO-2022073469-A1_GS-188 . O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(N8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C35H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CITZS0 WO-2022073469-A1_GS-189 . O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(N8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C33H32N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HMU8K7 WO-2022073469-A1_GS-190 . CN1CCN(C2=CC=C3N=CC(C4=CN([C@H]5C[C@@H](CNC6=CC7=C(C=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)C5)N=C4)=NC3=C2)CC1 Degrader C34H35N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-6AYEJE WO-2022073469-A1_GS-191 . O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@H](N5C=C(C6=NC7=CC(N8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C33H32N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5SIPB8 SCHEMBL27091387 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidine-1-carbonyl]cyclobutyl]methylamino]isoindole-1,3-dione; SCHEMBL30875427 O=C1CCC(N2C(=O)C3=C(C=C(NCC4CC(C(=O)N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)C4)C=C3)C2=O)C(=O)N1 Degrader C35H34N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9YZC5T WO-2022073469-A1_GS-193 . O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(C8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-81ZCF5 SCHEMBL27091007 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidine-1-carbonyl]-1-bicyclo[1.1.1]pentanyl]ethylamino]isoindole-1,3-dione; SCHEMBL30875433 O=C1CCC(N2C(=O)C3=CC=C(NCCC45CC(C(=O)N6CCC(N7C=C(C8=NC9=CC=CC=C9N=C8)C=N7)CC6)(C4)C5)C=C3C2=O)C(=O)N1 Degrader C37H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BEEHKW WO-2022073469-A1_GS-195 . O=C1CCC(N2C(=O)C3=C(C=C(NCCCC4CC(N5C=C(C6=NC7=CC(N8CCNCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C35H37N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-1PR60T WO-2022073469-A1_GS-196 . O=C1CCC(N2C(=O)C3=C(C=C(NCCCC4CC(N5C=C(C6=NC7=CC(NC8CCNCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C36H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-37W6GD SCHEMBL27090832 3-[1-[3-[3-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]propyl]cyclobutyl]pyrazol-4-yl]quinoxaline-5-carbonitrile; SCHEMBL27092008; SCHEMBL30875377 N#CC1=C2N=C(C3=CN([C@H]4C[C@H](CCCNC5=CC6=C(C=C5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)N=C3)C=NC2=CC=C1 Degrader C32H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9WQFUH WO-2022073469-A1_GS-198 . N#CC1=CC2=N/C(C3=CN([C@H]4C[C@H](CCCNC5=CC6=C(C=C5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)N=C3)=C/N=C\2C=C1 Degrader C32H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YUEMGD SCHEMBL27091134 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(7-piperidin-4-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27135849 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(C8CCNCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C36H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-B7NNI2 SCHEMBL27090672 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-(3-methyl-4-quinoxalin-2-ylpyrazol-1-yl)cyclobutyl]methylamino]isoindole-1,3-dione CC1=NN(C2CC(CNC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)C=C1C1=NC2=CC=CC=C2N=C1 Degrader C30H27N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9WLBF2 WO-2022073469-A1_GS-201 . O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(F)=CC=C7N=C6)C=N5)C4)CC3C2=O)C(=O)N1 Degrader C31H30FN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-64K3VI SCHEMBL27090548 5-[3-[3-[4-(7-Cyclopropyloxyquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091964; SCHEMBL30875521 O=C1CCC(N2C(=O)C3=CC=C(NCCCC4CC(N5C=C(C6=NC7=CC(OC8CC8)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C34H33N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-S1MIQO SCHEMBL27090719 5-[3-[3-[4-[7-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27139776 O=C1CCC(N2C(=O)C3=C(C=C(NCCCC4CC(N5C=C(C6=NC7=CC(N8C[C@@H]9C[C@H]8CN9)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C36H37N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-VVOHRN SCHEMBL27091289 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(7-piperidin-4-yloxyquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092026 O=C1CCC(N2C(=O)C3=C(C=C(NCCCC4CC(N5C=C(C6=NC7=CC(OC8CCNCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C36H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-6XN806 SCHEMBL27090967 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidine-1-carbonyl]cyclobutyl]ethylamino]isoindole-1,3-dione; SCHEMBL30875291 O=C1CCC(N2C(=O)C3=CC=C(NCCC4CC(C(=O)N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)C4)C=C3C2=O)C(=O)N1 Degrader C36H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-TW13WQ SCHEMBL27090969 5-[3-[3-[4-(7-Chloroquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27136720; SCHEMBL30875467 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@H](N5C=C(C6=C\N=C7\C=CC(Cl)=C\C7=N\6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C31H28ClN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UI83BR WO-2022073469-A1_GS-207 . O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(N8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C35H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CVXLW4 SCHEMBL27090576 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[7-(morpholin-4-ylmethyl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091950 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(CN8CCOCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C36H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KQJYLA SCHEMBL27091180 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[7-(piperazin-1-ylmethyl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27134887 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(CN8CCNCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C36H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-MLCKS9 SCHEMBL27090768 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[7-(oxan-4-yl)quinoxalin-2-yl]-3-(trifluoromethyl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091959 O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(C8CCOCC8)=CC=C7N=C6)C(C(F)(F)F)=N5)C4)C=C3C2=O)C(=O)N1 Degrader C37H36F3N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KI21UZ SCHEMBL27090739 5-[[5-[4-[3-Cyclopropyl-4-(7-piperazin-1-ylquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]-5-oxopentyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(NCCCCC(=O)N4CCC(N5C=C(C6=NC7=CC(N8CCNCC8)=CC=C7N=C6)C(C6CC6)=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C41H46N10O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PBYG9C SCHEMBL27091013 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[7-(trifluoromethyl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091988 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(C(F)(F)F)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C32H28F3N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BRQ639 SCHEMBL27091397 5-[3-[3-[3-Cyclopropyl-4-[7-(oxan-4-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27092041; SCHEMBL30875283 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(C8CCOCC8)=CC=C7N=C6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C39H41N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-1YTCKH WO-2022073469-A1_GS-214 . O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(NC8CCNCC8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C36H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-1H3OZG SCHEMBL27091102 5-[3-[3-[4-[7-(3,8-Diazabicyclo[3.2.1]octan-3-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27136163; SCHEMBL30875299 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(N8CC9CCC(C8)N9)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C37H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HOPJTZ SCHEMBL27091121 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[4-(6-morpholin-4-ylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=NC(N7CCOCC7)=CC=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C30H31N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OR7ANC SCHEMBL27090611 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(6-morpholin-4-ylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27141055 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=CC=CC(N7CCOCC7)=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H35N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4V6Z8L SCHEMBL24289579 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[4-[6-(oxan-4-ylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione; SCHEMBL27090748 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=CC=CC(NC7CCOCC7)=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C31H33N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CX636V SCHEMBL27090740 5-[3-[3-[4-(5-Chloroquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27092055; SCHEMBL30875426 O=C1CCC(N2C(=O)C3=CC=C(NCCCC4CC(N5C=C(C6=NC7=CC=CC(Cl)=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C31H28ClN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-MUWF2E SCHEMBL27090992 5-[3-[3-[4-[7-(4,7-Diazaspiro[2.5]octan-7-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091989; SCHEMBL30875318 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(N8CCNC9(CC9)C8)=CC=C7N=C6)C=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C37H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-Q051WV WO-2022073469-A1_GS-221 . CC1=NN([C@H]2C[C@@H](CCCNC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)C=C1C1=NC2=CC(N3CCOCC3)=CC=C2N=C1 Degrader C36H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-1XIAMG SCHEMBL24290259 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[6-(oxan-4-ylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091325 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=CC=CC(NC7CCOCC7)=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HSYQJM SCHEMBL27090994 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[3-methyl-4-[7-(oxan-4-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27134932 CC1=NN([C@H]2C[C@@H](CCCNC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)C=C1C1=NC2=CC(C3CCOCC3)=CC=C2N=C1 Degrader C37H39N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HZP6ZY SCHEMBL27090671 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[7-(1-methylpiperidin-4-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27134930 CN1CCC(C2=CC=C3N=CC(C4=CN([C@H]5C[C@H](CCCNC6=CC7=C(C=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)C5)N=C4)=NC3=C2)CC1 Degrader C37H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OE1WDN SCHEMBL27090925 3-[3-oxo-5-[4-[3-(4-quinoxalin-2-ylpyrazol-1-yl)cyclobutyl]butyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875528 O=C1CCC(N2CC3=C\C=C(CCCCC4CC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)/C=C\3C2=O)C(=O)N1 Degrader C32H32N6O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-T2N3Z4 SCHEMBL27091028 3-[3-oxo-6-[4-[3-(4-quinoxalin-2-ylpyrazol-1-yl)cyclobutyl]butyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875330 O=C1CCC(N2CC3=CC(CCCCC4CC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)=CC=C3C2=O)C(=O)N1 Degrader C32H32N6O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-F74NM9 WO-2022073469-A1_GS-227 . O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(N8CCOCC8)=CC=C7N=C6)C(C6CC6)=N5)C4)C=C3C2=O)C(=O)N1 Degrader C38H40N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-NTSX7X SCHEMBL27090957 5-[3-[3-[3-Cyclopropyl-4-[7-(piperazin-1-ylmethyl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091987; SCHEMBL30875555 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(CN8CCNCC8)=CC=C7N=C6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C39H43N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CJFD34 SCHEMBL27090780 5-[3-[3-[3-Cyclopropyl-4-(7-piperidin-4-yloxyquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091961; SCHEMBL30875544 O=C1CCC(N2C(=O)C3=C(C=C(NCCCC4CC(N5C=C(C6=NC7=CC(OC8CCNCC8)=CC=C7N=C6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C39H42N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ZBSP3H SCHEMBL27090874 5-[3-[3-[3-Cyclopropyl-4-[7-(morpholin-4-ylmethyl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27150746; SCHEMBL30875246 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCC4CC(N5C=C(C6=NC7=CC(CN8CCOCC8)=CC=C7N=C6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C39H42N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KM3814 SCHEMBL27090716 5-[3-[3-[3-Cyclopropyl-4-(7-piperidin-4-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27134908; SCHEMBL30875561 O=C1CCC(N2C(=O)C3=C(C=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC(C8CCNCC8)=CC=C7N=C6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C39H42N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-54IDVT SCHEMBL24290753 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-phenylpyrazol-1-yl)cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091991; SCHEMBL30875584 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=CC=CC=C6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C29H29N5O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JR2JPX SCHEMBL27090950 2-[1-[3-[3-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]propyl]cyclobutyl]pyrazol-4-yl]quinoxaline-5-carbonitrile; SCHEMBL27091977; SCHEMBL30875534 N#CC1=C2N=CC(C3=CN([C@H]4C[C@H](CCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)N=C3)=NC2=CC=C1 Degrader C32H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-WD25KP SCHEMBL27090655 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(5-fluoroquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27152303 O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC=CC(F)=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C31H28FN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-XPLIIZ SCHEMBL24288918 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-pyrazin-2-ylpyrazol-1-yl)cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27090555; SCHEMBL27091981 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=CN=CC=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C27H27N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-NWCQPZ SCHEMBL24289570 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[6-(oxan-4-yl)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL24290758; SCHEMBL30875462 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC(C7CCOCC7)=CC=C6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H36N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9CJSXV SCHEMBL24289676 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[6-(1-methylpiperidin-4-yl)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091273 CN1CCC(C2=CC=CC(C3=CN([C@H]4C[C@H](CCCNC5=C/C6=C(\C=C/5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)N=C3)=N2)CC1 Degrader C34H39N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-IZS3F2 SCHEMBL27090901 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(6-piperidin-4-ylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091967 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC(C7CCNCC7)=CC=C6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H37N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-6WS2HR SCHEMBL24290764 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(2-morpholin-4-ylpyrimidin-4-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27140094; SCHEMBL29590538 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC(N7CCOCC7)=NC=C6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C31H34N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-QI8LI4 SCHEMBL24289224 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(4-morpholin-4-ylpyrimidin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27090679 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC(N7CCOCC7)=CC=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C31H34N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ZLJ7NL SCHEMBL24289300 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(3-morpholin-4-ylphenyl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27090688 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=CC(N7CCOCC7)=CC=C6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H36N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PS6VW6 SCHEMBL27090926 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-pyrimidin-2-ylpyrazol-1-yl)cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091973 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC=CC=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C27H27N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-NOAWTZ SCHEMBL27090541 5-[3-[3-[3-(Difluoromethyl)-4-quinoxalin-2-ylpyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091975; SCHEMBL30875392 O=C1CCC(N2C(=O)C3=CC=C(NCCCC4CC(N5C=C(C6=NC7=CC=CC=C7N=C6)C(C(F)F)=N5)C4)C=C3C2=O)C(=O)N1 Degrader C32H29F2N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-8YDCA9 SCHEMBL24290791 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[3-methyl-4-(6-morpholin-4-ylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27090769 CC1=NN([C@H]2C[C@H](CCCNC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)C=C1C1=NC(N2CCOCC2)=CC=C1 Degrader C33H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-3XYTHL SCHEMBL24291524 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27090935 CN1CCN(C2=CC=CC(C3=CN([C@H]4C[C@H](CCCNC5=C/C6=C(\C=C/5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)N=C3)=N2)CC1 Degrader C33H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-AWM3MM SCHEMBL27090737 5-[3-[3-[3-Cyclopropyl-4-(6-morpholin-4-ylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27092005; SCHEMBL30875251 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC(N7CCOCC7)=CC=C6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C35H39N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-2738IY SCHEMBL27091068 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(6-piperazin-1-ylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27135877 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC(N7CCNCC7)=CC=C6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H36N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-N2TRP6 SCHEMBL24291527 5-[3-[3-[4-[6-(Dimethylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090680; SCHEMBL30875570 CN(C)C1=CC=CC(C2=CN([C@H]3C[C@H](CCCNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2)=N1 Degrader C30H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-0ZJHPW SCHEMBL24291525 2-(2,6-dioxopiperidin-3-yl)-5-[3-[3-[4-(6-oxo-1H-pyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27134565; SCHEMBL29589603 O=C1C=CC=C(C2=CN(C3CC(CCCNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2)N1 Degrader C28H28N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-TGGO0Q SCHEMBL27091282 5-[3-[3-[4-[5-(Azetidin-3-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27136138; SCHEMBL30875388 O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC=CC(C8CNC8)=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C34H34N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-I26UVS SCHEMBL24291520 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[6-(methylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27136120; SCHEMBL30875237 CNC1=CC=CC(C2=CN([C@H]3C[C@H](CCCNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2)=N1 Degrader C29H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YOO8TL SCHEMBL27090887 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[6-(4-hydroxypiperidin-1-yl)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092009 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC(N7CCC(O)CC7)=CC=C6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-RTD7I7 SCHEMBL24289635 5-[[3-[3-Cyclopropyl-4-(4-methylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090862; SCHEMBL30875424 CC1=CC=NC(C2=CN([C@H]3C[C@H](CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C2CC2)=C1 Degrader C30H30N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-16WE0P SCHEMBL24290383 5-[[3-[3-Cyclopropyl-4-(4-methoxypyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875397 COC1=CC=NC(C2=CN([C@H]3C[C@H](CNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C3)N=C2C2CC2)=C1 Degrader C30H30N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-FO3BYC SCHEMBL27091136 5-[[3-[4-(5-Chloropyridin-2-yl)-3-cyclopropylpyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875642 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=NC=C(Cl)C=C6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H27ClN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4QVOG0 SCHEMBL24290385 5-[[3-[3-Cyclopropyl-4-(5-methylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875432 CC1=CN=C(C2=CN(C3CC(CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C2CC2)C=C1 Degrader C30H30N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5AUVXH SCHEMBL24290395 5-[[3-[4-[6-(Azetidin-1-yl)pyridin-2-yl]-3-cyclopropylpyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091323; SCHEMBL30875564 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=CC=CC(N7CCC7)=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-EJJM4C SCHEMBL27090767 5-[[3-[4-[6-(Cyclobutylamino)pyridin-2-yl]-3-cyclopropylpyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875501 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=CC=CC(NC7CCC7)=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H35N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-K6EQQE SCHEMBL24290665 5-[[3-[3-Cyclopropyl-4-[6-(dimethylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091218; SCHEMBL30875260 CN(C)C1=NC(C2=CN([C@H]3C[C@H](CNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2C2CC2)=CC=C1 Degrader C31H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-GDBZWY SCHEMBL27090955 5-[[3-[3-Cyclopropyl-4-[6-(oxetan-3-ylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875369 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=CC=CC(NC7COC7)=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H33N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LMTYM2 SCHEMBL27090819 5-[[3-[3-Cyclopropyl-4-(3-methylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875302 CC1=C(C2=CN([C@H]3C[C@H](CNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2C2CC2)N=CC=C1 Degrader C30H30N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ZFJ3F3 SCHEMBL24289659 5-[[3-[3-Cyclopropyl-4-(3-methoxypyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090699; SCHEMBL30875636 COC1=C(C2=CN([C@H]3C[C@H](CNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2C2CC2)N=CC=C1 Degrader C30H30N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5GARR6 SCHEMBL24291489 5-[[3-[3-Cyclopropyl-4-[6-(methylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091211; SCHEMBL30875512 CNC1=CC=CC(C2=CN(C3CC(CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C2CC2)=N1 Degrader C30H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-U9U6P1 SCHEMBL24291493 5-[[3-[4-(4-Chloropyridin-2-yl)-3-cyclopropylpyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875449 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=CC(Cl)=CC=N6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H27ClN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-0JHJO3 SCHEMBL27091111 5-[[3-(3-Cyclopropyl-4-pyridin-4-ylpyrazol-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875461 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=CC=NC=C6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H28N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-2DTRFT SCHEMBL27090662 5-[[3-[3-Cyclopropyl-4-(5-morpholin-4-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875556 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=NC7=CC=CC(N8CCOCC8)=C7N=C6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C36H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-IQYO9K SCHEMBL27091231 5-[[3-[3-Cyclopropyl-4-[5-(4-methylpiperazin-1-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875525 CN1CCN(C2=C3N=CC(C4=CN([C@H]5C[C@H](CNC6=CC7=C(C=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)C5)N=C4C4CC4)=NC3=CC=C2)CC1 Degrader C37H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-S2RHSJ SCHEMBL27090610 5-[[3-(3-Cyclopropyl-4-pyridin-3-ylpyrazol-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875270 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=CC=CN=C6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H28N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KF63TX SCHEMBL27091014 5-[[3-[3-Cyclopropyl-4-[6-[(3-hydroxycyclobutyl)amino]pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875526 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=CC=CC(NC7CC(O)C7)=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H35N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PF6L2E SCHEMBL27091322 5-[[3-[3-cyclopropyl-4-(6-oxo-1H-pyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875244 O=C1C=CC=C(C2=CN(C3CC(CNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2C2CC2)N1 Degrader C29H28N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4574L1 SCHEMBL27090827 2-(3-cyclopropyl-4-quinoxalin-2-ylpyrazol-1-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methyl]acetamide O=C(CN1C=C(C2=NC3=CC=CC=C3N=C2)C(C2CC2)=N1)NCC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C30H25N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9S75AH SCHEMBL24288931 5-[[3-[4-(3-Chloropyridin-2-yl)-3-cyclopropylpyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090633; SCHEMBL30875518 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=C(Cl)C=CC=N6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C29H27ClN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-Z5B4SA SCHEMBL27090636 5-[[3-[4-(6-Aminopyridin-2-yl)-3-cyclopropylpyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875508 NC1=NC(C2=CN([C@H]3C[C@H](CNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2C2CC2)=CC=C1 Degrader C29H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-AAAGPM SCHEMBL27091074 5-[[3-[4-[6-(Azetidin-3-ylamino)pyridin-2-yl]-3-cyclopropylpyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875559 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=CC=CC(NC7CNC7)=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H34N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-S4C56X SCHEMBL24291751 5-[[3-[3-Cyclopropyl-4-(5-methoxypyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090810; SCHEMBL30875428 COC1=CC=C(C2=CN([C@H]3C[C@H](CNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2C2CC2)N=C1 Degrader C30H30N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4DSEVY SCHEMBL24291560 5-[[3-[3-Cyclopropyl-4-[5-(dimethylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875282 CN(C)C1=CC=C(C2=CN([C@H]3C[C@H](CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C2CC2)N=C1 Degrader C31H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-EXDVTJ SCHEMBL27090732 5-[[3-[3-Cyclopropyl-4-[3-(trifluoromethyl)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875389 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=C(C(F)(F)F)C=CC=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C30H27F3N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-J4GB0E SCHEMBL27091144 5-[[3-[3-cyclopropyl-4-(1H-pyrrolo[3,2-c]pyridin-4-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875275 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=C7C=CNC7=CC=N6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-3VFUM5 SCHEMBL27091402 5-[[3-[3-cyclopropyl-4-(1H-pyrrolo[2,3-c]pyridin-5-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875483 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=NC=C7NC=CC7=C6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-IEI4CP WO-2022073469-A1_GS-280 . CC1=CC(NC[C@H]2C[C@H](N3C=C(C4=C5C=CN=CC5=CC=N4)C(C4CC4)=N3)C2)=CC=C1C(=O)N(C=O)C1CCC(=O)NC1=O Degrader C33H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-H46PMA SCHEMBL27090774 5-[[3-[3-Cyclopropyl-4-(1,6-naphthyridin-5-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875368 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(/C6=N/C=C\C7=C6C=CC=N7)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C32H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-IEO9OB SCHEMBL27091041 5-[[3-[3-cyclopropyl-4-(1H-pyrrolo[3,2-c]pyridin-6-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875545 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=C/C7=C(C=CN7)/C=N\6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-XRX29S SCHEMBL24290857 5-[[3-[3-Cyclopropyl-4-(5-fluoropyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090674; SCHEMBL30875612 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=CC=C(F)C=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C29H27FN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-3BYJKH SCHEMBL27091023 5-[[3-[3-Cyclopropyl-4-(2,7-naphthyridin-1-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875537 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=C7\C=NC=C\C7=C\C=N\6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C32H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YTN7XU SCHEMBL27091188 5-[[3-(3-Cyclopropyl-4-pyrido[3,4-b]pyrazin-7-ylpyrazol-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875472 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=NC=C7N=CC=NC7=C6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C31H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HQQ1OW SCHEMBL27090883 5-[[3-[3-Cyclopropyl-4-(1,7-naphthyridin-8-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875480 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=C7N=CC=CC7=CC=N6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C32H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-I5I6ML WO-2022073469-A1_GS-287 . O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=C(OCF)C=CC=N6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C30H29FN6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5NQ0HR SCHEMBL27090635 5-[[3-[3-cyclopropyl-4-(1H-pyrazolo[4,3-c]pyridin-6-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875277 O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@H](N5C=C(C6=NC=C7C=NNC7=C6)C(C6CC6)=N5)C4)C=C3C2=O)C(=O)N1 Degrader C30H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-70NLHH SCHEMBL24289699 5-[[3-[3-Cyclopropyl-4-(2-fluorophenyl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090905; SCHEMBL30875520 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=CC=CC=C6F)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C30H28FN5O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-B13D9P SCHEMBL24290167 5-[[3-[3-Cyclopropyl-4-(4-fluoropyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875375 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=CC(F)=CC=N6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H27FN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-8PZ4BY SCHEMBL27091394 5-[[3-[3-cyclopropyl-4-(1H-pyrrolo[2,3-c]pyridin-7-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875321 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(/C6=N/C=C\C7=C6NC=C7)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-A7W81J SCHEMBL27090855 5-[[3-[3-Cyclopropyl-4-[6-[(1-methylazetidin-3-yl)amino]pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875573 CN1CC(NC2=NC(C3=CN([C@H]4C[C@H](CNC5=C/C6=C(\C=C/5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)N=C3C3CC3)=CC=C2)C1 Degrader C33H36N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-NG8FHL SCHEMBL27090842 5-[[3-[3-cyclopropyl-4-(1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875354 O=C1CCC(N2C(=O)C3=CC=C(NCC4CC(N5C=C(C6=N\C=C7\NN=C\C7=C\6)C(C6CC6)=N5)C4)C=C3C2=O)C(=O)N1 Degrader C30H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-Z4LY26 SCHEMBL27090928 5-[[3-[3-Cyclopropyl-4-[4-(piperidin-4-ylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875261 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=CC(NC7CCNCC7)=CC=N6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C34H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-N5F7GQ SCHEMBL24288929 5-[[3-[3-Cyclopropyl-4-[4-[(1-methylpiperidin-4-yl)amino]pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090609; SCHEMBL30875257 CN1CCC(NC2=CC=NC(C3=CN([C@H]4C[C@H](CNC5=C/C=C6/C(=O)N(C7CCC(=O)NC7=O)C(=O)/C6=C\5)C4)N=C3C3CC3)=C2)CC1 Degrader C35H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-31DIZS SCHEMBL24289683 5-[[3-[3-Cyclopropyl-4-(3-fluoropyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875248 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=C(F)C=CC=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C29H27FN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5BC507 SCHEMBL27090979 5-[[3-[3-Cyclopropyl-4-(5-piperazin-1-ylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875578 O=C1CCC(N2C(=O)C3=C(/C=C(NCC4CC(N5C=C(C6=CC=C(N7CCNCC7)C=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C33H36N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UB9XN5 SCHEMBL24289678 5-[[3-[3-Cyclopropyl-4-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091278; SCHEMBL30875504 CN1CCN(C2=CC=C(C3=CN([C@H]4C[C@H](CNC5=C/C6=C(\C=C/5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)N=C3C3CC3)N=C2)CC1 Degrader C34H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-2B10JN SCHEMBL27090626 5-[[3-[3-cyclopropyl-4-(1H-pyrazolo[4,3-c]pyridin-4-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875489 O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@H](N5C=C(C6=C7C=NNC7=CC=N6)C(C6CC6)=N5)C4)C=C3C2=O)C(=O)N1 Degrader C30H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-AD3E64 WO-2022073469-A1_GS-300 5-[[3-[3-Cyclopropyl-4-[3-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CN1CCN(C2=CC=CN=C2C2=CN([C@H]3C[C@H](CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C2CC2)CC1 Degrader C34H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BOMHZN SCHEMBL24290858 5-[[3-[3-Cyclopropyl-4-[5-(methylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091140; SCHEMBL30875273 CNC1=CC=C(C2=CN([C@H]3C[C@H](CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C2CC2)N=C1 Degrader C30H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BA3Q05 SCHEMBL27090593 5-[[3-[3-Cyclopropyl-4-[5-(piperidin-4-ylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875250 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=CC=C(NC7CCNCC7)C=N6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C34H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KWU8PF SCHEMBL27090700 5-[[3-[3-Cyclopropyl-4-[5-[(1-methylpiperidin-4-yl)amino]pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875417 CN1CCC(NC2=CC=C(C3=CN([C@H]4C[C@H](CNC5=C/C=C6/C(=O)N(C7CCC(=O)NC7=O)C(=O)/C6=C\5)C4)N=C3C3CC3)N=C2)CC1 Degrader C35H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-QZCD22 SCHEMBL24290864 5-[[3-[3-Cyclopropyl-4-[3-(piperidin-4-ylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090980; SCHEMBL30875258 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=NC=CC=C6NC6CCNCC6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C34H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-Z4ADAY SCHEMBL24289388 5-[[3-[3-Cyclopropyl-4-(5-fluoro-6-methylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091286; SCHEMBL30875479 CC1=C(F)C=CC(C2=CN([C@H]3C[C@H](CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C2CC2)=N1 Degrader C30H29FN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-55TBLQ SCHEMBL27090770 5-[[3-[3-Cyclopropyl-4-[4-(methylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875400 CNC1=CC(C2=CN([C@H]3C[C@H](CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C2CC2)=NC=C1 Degrader C30H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-E3HBKG SCHEMBL27090540 5-[[3-[3-cyclopropyl-4-(3H-imidazo[4,5-c]pyridin-6-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875466 O=C1CCC(N2C(=O)C3=CC=C(NC[C@H]4C[C@H](N5C=C(C6=N\C=C7\N=CN\C7=C\6)C(C6CC6)=N5)C4)C=C3C2=O)C(=O)N1 Degrader C30H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-FL5MX6 WO-2022073469-A1_GS-308 . O=C1CCC(N2C(=O)C3C=CC(NC[C@H]4C[C@H](N5C=C(C6=CC=C7CCCCC7=N6)C(C6CC6)N5)C4)=CC3C2=O)C(=O)N1 Degrader C33H38N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UIAN0C SCHEMBL24288917 5-[[3-(3-Cyclopropyl-4-pyrido[3,4-b]pyrazin-5-ylpyrazol-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091245; SCHEMBL30875478 O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(C6=C7N=CC=NC7=CC=N6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C31H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YSYKTB SCHEMBL27090899 5-[[3-[3-cyclopropyl-4-(1H-pyrazolo[3,4-c]pyridin-7-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875580 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=C7NN=CC7=CC=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C30H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-8D8474 SCHEMBL24292122 5-[3-[3-[4-(3-Chloropyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090638; SCHEMBL27133984; SCHEMBL30875286 O=C1CCC(N2C(=O)C3=C(/C=C(NCCC[C@H]4C[C@H](N5C=C(C6=C(Cl)C=CC=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C28H27ClN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-3W2HIA SCHEMBL24289483 3-(3-cyclopropyl-4-quinoxalin-2-ylpyrazol-1-yl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methyl]propanamide O=C(CCN1C=C(C2=NC3=CC=CC=C3N=C2)C(C2CC2)=N1)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C31H27N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-K84OTB SCHEMBL24290046 5-[[3-(3-Cyclopropyl-4-quinoxalin-2-ylpyrazol-1-yl)propylamino]methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(CNCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C(C5CC5)=N4)\C=C/3)C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5K156I SCHEMBL27091210 5-[[3-[3-Cyclopropyl-4-[6-(4-methylpiperazin-1-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875503 CN1CCN(C2=CC=C3N=C(C4=CN([C@H]5C[C@H](CNC6=CC7=C(C=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)C5)N=C4C4CC4)C=NC3=C2)CC1 Degrader C37H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5DF9HK SCHEMBL24288960 5-[6-[4-(8-Bromoquinoxalin-2-yl)pyrazol-1-yl]hexylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL29589522 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCCN4C=C(C5=NC6=C(Br)C=CC=C6N=C5)C=N4)\C=C/3)C2=O)C(=O)N1 Degrader C30H28BrN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5TKQAM SCHEMBL24292221 N-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]propyl]-2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]acetamide; SCHEMBL29589584 O=C(CN1CCC(N2C=C(C3=NC4=C\C=C/C=C\4N=C3)C=N2)CC1)NCCCNC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C34H35N9O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-MXXSS0 SCHEMBL27091163 N-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]propyl]-2-[4-(4-quinolin-2-ylpyrazol-1-yl)piperidin-1-yl]acetamide; SCHEMBL29590801 O=C(CN1CCC(N2C=C(C3=NC4=CC=CC=C4C=C3)C=N2)CC1)NCCCNC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C35H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-GC0KCE SCHEMBL24288962 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-oxo-4-(4-pyridin-2-ylpiperazin-1-yl)butyl]amino]isoindole-1,3-dione; SCHEMBL30875491 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCC(=O)N4CCN(C5=NC=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C26H28N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-12CPAZ SCHEMBL27091248 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-oxo-4-(4-phenylpiperazin-1-yl)butyl]amino]isoindole-1,3-dione; SCHEMBL30875529 O=C1CCC(N2C(=O)C3=CC=C(NCCCC(=O)N4CCN(C5=CC=CC=C5)CC4)C=C3C2=O)C(=O)N1 Degrader C27H29N5O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-TO9J8L AKOS017066624 2-(6,7-dimethyl-1-benzofuran-3-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide\; SCHEMBL22216481; AKOS017066624 Cc1cnc(NC(=O)Cc2coc3c(C)c(C)ccc23)s1 Degrader C16H16N2O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-WJY6M2 SCHEMBL24341140 2-(1-benzothiophen-2-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24341140 O=C(Cc1cc2ccccc2s1)Nc1ncc(C(F)(F)F)s1 Degrader C14H9F3N2OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-KKCI08 SCHEMBL24341881 2-(1-benzothiophen-2-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]propanamide\; SCHEMBL24341881 CC(C(=O)Nc1ncc(C(F)(F)F)s1)c1cc2ccccc2s1 Degrader C15H11F3N2OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-RQOG46 SCHEMBL24343217 2-(3-methyl-1-benzothiophen-2-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24343217 Cc1c(CC(=O)Nc2ncc(C(F)(F)F)s2)sc2ccccc12 Degrader C15H11F3N2OS2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-8WGVWM 2-quinolin-5-yl-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide SCHEMBL24343222 O=C(Cc1cccc2ncccc12)Nc1ncc(C(F)(F)F)s1 Degrader C15H10F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-E9GU2W 2-quinolin-6-yl-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide SCHEMBL24343228 O=C(Cc1ccc2ncccc2c1)Nc1ncc(C(F)(F)F)s1 Degrader C15H10F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-N5ZTQQ SCHEMBL24343203 2-(6-methylbenzimidazol-1-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24343203 Cc1ccc2ncn(CC(=O)Nc3ncc(C(F)(F)F)s3)c2c1 Degrader C14H11F3N4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-39VLK3 SCHEMBL24341150 1-(4-methylphenyl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24341150 Cc1ccc(N2CC(C(=O)Nc3ncc(C(F)(F)F)s3)CC2=O)cc1 Degrader C16H14F3N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-5IMXC8 SCHEMBL24341147 1-(4-fluoro-3-methylphenyl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24341147 Cc1cc(N2CC(C(=O)Nc3ncc(C(F)(F)F)s3)CC2=O)ccc1F Degrader C16H13F4N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-8BCSIT SCHEMBL24341148 1-(4-chlorophenyl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24341148 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(c2ccc(Cl)cc2)C1 Degrader C15H11ClF3N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-94JQ23 SCHEMBL24341149 1-(3-chlorophenyl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24341149 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(c2cccc(Cl)c2)C1 Degrader C15H11ClF3N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-JN8KJE SCHEMBL20588990 2-(6,7-dimethyl-1-benzofuran-3-yl)-N-(5-propan-2-yl-1,3-thiazol-2-yl)acetamide\; SCHEMBL20588990 Cc1ccc2c(CC(=O)Nc3ncc(C(C)C)s3)coc2c1C Degrader C18H20N2O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-Q87AQ5 SCHEMBL24343234 1-(2-chlorophenyl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24343234 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(c2ccccc2Cl)C1 Degrader C15H11ClF3N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-9M2R8G SCHEMBL24342111 1-(3,5-difluorophenyl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24342111 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(c2cc(F)cc(F)c2)C1 Degrader C15H10F5N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-YLIC6B SCHEMBL24341160 1-(2,5-difluorophenyl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24341160 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(c2cc(F)ccc2F)C1 Degrader C15H10F5N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-BQTKFS SCHEMBL24343215 1-(3,4-difluorophenyl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24343215 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(c2ccc(F)c(F)c2)C1 Degrader C15H10F5N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-TYOGSK SCHEMBL24342093 1-(2,3-dihydro-1H-inden-5-yl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24342093 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(c2ccc3c(c2)CCC3)C1 Degrader C18H16F3N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-O99714 SCHEMBL24343202 1-(1,3-benzodioxol-5-yl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24343202 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(c2ccc3c(c2)OCO3)C1 Degrader C16H12F3N3O4S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-LA9M59 SCHEMBL24341890 1-(4-fluorophenyl)-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24341890 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(c2ccc(F)cc2)C1 Degrader C15H11F4N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-OEH72M SCHEMBL24342116 1-benzyl-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24342116 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(Cc2ccccc2)C1 Degrader C16H14F3N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-0KJES2 SCHEMBL24343221 1-[(4-chlorophenyl)methyl]-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24343221 O=C(Nc1ncc(C(F)(F)F)s1)C1CC(=O)N(Cc2ccc(Cl)cc2)C1 Degrader C16H13ClF3N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-U6E4EH SCHEMBL24343220 1-[(4-methylphenyl)methyl]-5-oxo-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide\; SCHEMBL24343220 Cc1ccc(CN2CC(C(=O)Nc3ncc(C(F)(F)F)s3)CC2=O)cc1 Degrader C17H16F3N3O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-95AJZT SCHEMBL24341139 N-(5-chloro-1,3-thiazol-2-yl)-2-(6,7-dimethyl-1-benzofuran-3-yl)acetamide\; SCHEMBL24341139 Cc1ccc2c(CC(=O)Nc3ncc(Cl)s3)coc2c1C Degrader C15H13ClN2O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-DYAG9M 2-isoquinolin-5-yl-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide SCHEMBL24341158 O=C(Cc1cccc2cnccc12)Nc1ncc(C(F)(F)F)s1 Degrader C15H10F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-GYRBSS 2-isoquinolin-6-yl-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide SCHEMBL24342094 O=C(Cc1ccc2cnccc2c1)Nc1ncc(C(F)(F)F)s1 Degrader C15H10F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-MA9MKF 2-isoquinolin-7-yl-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide SCHEMBL24343224 O=C(Cc1ccc2ccncc2c1)Nc1ncc(C(F)(F)F)s1 Degrader C15H10F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-O3Q81F 2-isoquinolin-8-yl-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide SCHEMBL24343223 O=C(Cc1cccc2ccncc12)Nc1ncc(C(F)(F)F)s1 Degrader C15H10F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-E73S6U 2-isoquinolin-4-yl-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide SCHEMBL24343211 O=C(Cc1cncc2ccccc12)Nc1ncc(C(F)(F)F)s1 Degrader C15H10F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-31A8QH 2-quinolin-3-yl-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]propanamide SCHEMBL24342118 CC(C(=O)Nc1ncc(C(F)(F)F)s1)c1cnc2ccccc2c1 Degrader C16H12F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-GG8DGM 2-quinolin-3-yl-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide SCHEMBL24341893 O=C(Cc1cnc2ccccc2c1)Nc1ncc(C(F)(F)F)s1 Degrader C15H10F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-KMD6OE SCHEMBL24342123 2-(5-methylindol-1-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24342123 Cc1ccc2c(ccn2CC(=O)Nc2ncc(C(F)(F)F)s2)c1 Degrader C15H12F3N3OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-04SYJS SCHEMBL24341816 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24341816 O=C(Cc1c[nH]c2ncccc12)Nc1ncc(C(F)(F)F)s1 Degrader C13H9F3N4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-TVLRTK SCHEMBL24343232 2-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24343232 O=C(Cc1c[nH]c2nccc(Cl)c12)Nc1ncc(C(F)(F)F)s1 Degrader C13H8ClF3N4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-PMUOQ3 SCHEMBL24341142 2-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-N-(5-propan-2-yl-1,3-thiazol-2-yl)acetamide\; SCHEMBL24341142 CC(C)c1cnc(NC(=O)Cc2cn3cc(F)ccc3n2)s1 Degrader C15H15FN4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-L0H1GJ SCHEMBL24341155 2-(1H-pyrrolo[3,2-b]pyridin-3-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24341155 O=C(Cc1c[nH]c2cccnc12)Nc1ncc(C(F)(F)F)s1 Degrader C13H9F3N4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-F7DPZZ SCHEMBL24342092 2-(1-benzofuran-2-yl)-N-[5-(trifluoromethyl)-1,3-thiazol-2-yl]acetamide\; SCHEMBL24342092 O=C(Cc1cc2ccccc2o1)Nc1ncc(C(F)(F)F)s1 Degrader C14H9F3N2O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-IHCKMY SCHEMBL24342095 N-(5-cyclopropyl-1,3-thiazol-2-yl)-2-(6,7-dimethyl-1-benzofuran-3-yl)acetamide\; SCHEMBL24342095 Cc1ccc2c(CC(=O)Nc3ncc(C4CC4)s3)coc2c1C Degrader C18H18N2O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-K77GL2 SCHEMBL24341738 N-(5-cyclopropyl-1,3-thiazol-2-yl)-2-(6-fluoroimidazo[1,2-a]pyridin-2-yl)acetamide\; SCHEMBL24341738 O=C(Cc1cn2cc(F)ccc2n1)Nc1ncc(C2CC2)s1 Degrader C15H13FN4OS CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2022079290-A2 TPD-L3YXE2 SCHEMBL29060212 4-[4-[6-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-1,2,3,4-tetrahydronaphthalen-1-yl]piperazin-1-yl]-3-fluorobenzonitrile\; SCHEMBL29060212 N#Cc1ccc(N2CCN(C3CCCc4cc(COc5cccc6c5CN([C@H]5CCC(=O)NC5=O)C6=O)ccc43)CC2)c(F)c1 Degrader C35H34FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022148358-A1 TPD-XS5O2Z SCHEMBL29060126 tert-butyl (4S)-5-amino-4-[7-[[5-[4-(4-cyano-2-fluorophenyl)piperazin-1-yl]-5,6,7,8-tetrahydronaphthalen-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate\; SCHEMBL29060126 CC(C)(C)OC(=O)CC[C@@H](C(N)=O)N1Cc2c(OCc3ccc4c(c3)CCCC4N3CCN(c4ccc(C#N)cc4F)CC3)cccc2C1=O Degrader C39H44FN5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022148358-A1 TPD-5INX0N SCHEMBL29059968 4-[4-[(1S)-6-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-1,2,3,4-tetrahydronaphthalen-1-yl]piperazin-1-yl]-3-fluorobenzonitrile\; SCHEMBL29059968 N#Cc1ccc(N2CCN([C@H]3CCCc4cc(COc5cccc6c5CN([C@H]5CCC(=O)NC5=O)C6=O)ccc43)CC2)c(F)c1 Degrader C35H34FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022148358-A1 TPD-HB04WR SCHEMBL29060055 4-[4-[(1R)-6-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-1,2,3,4-tetrahydronaphthalen-1-yl]piperazin-1-yl]-3-fluorobenzonitrile\; SCHEMBL29060055 N#Cc1ccc(N2CCN([C@@H]3CCCc4cc(COc5cccc6c5CN([C@H]5CCC(=O)NC5=O)C6=O)ccc43)CC2)c(F)c1 Degrader C35H34FN5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2022148358-A1 TPD-YHKYZA US20240383900, Compound PPA-001 (3R,4R)-4-[[[3-propan-2-yl-7-[(4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24791458; BDBM706339; US20240383900, Compound PPA-001 CC(C)c1cnn2c(NCc3ccc(-c4ccccn4)cc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C27H33N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-J2NUX1 US20240383900, Compound PPA-002 (3R,4R)-4-[[[3-propan-2-yl-7-[(4-pyridin-4-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24791457; BDBM706340; US20240383900, Compound PPA-002 CC(C)c1cnn2c(NCc3ccc(-c4ccncc4)cc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C27H33N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-VHI46I US20240383900, Compound PPA-003 (3R,4R)-4-[[[3-propan-2-yl-7-[(4-pyridin-3-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24791456; BDBM706341; US20240383900, Compound PPA-003 CC(C)c1cnn2c(NCc3ccc(-c4cccnc4)cc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C27H33N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-RORMB2 US20240383900, Compound PPA-004 (3R,4R)-4-[[[7-[(4-phenylphenyl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24791459; BDBM706342; US20240383900, Compound PPA-004 CC(C)c1cnn2c(NCc3ccc(-c4ccccc4)cc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C28H34N6O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-NQNNBC US20240383900, Compound PPA-005 (3R,4R)-4-[[[3-ethyl-7-[(4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792717; BDBM706343; US20240383900, Compound PPA-005 CCc1cnn2c(NCc3ccc(-c4ccccn4)cc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C26H31N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-9R72BZ US20240383900, Compound PPA-006 (3R,4R)-4-[[[3-cyclopropyl-7-[(4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792712; BDBM706344; US20240383900, Compound PPA-006 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ccccn3)cc2)n2ncc(C3CC3)c2n1 Degrader C27H31N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-GEOW37 US20240383900, Compound PPA-007 (3R,4R)-4-[[[3-propan-2-yl-7-[(4-pyrimidin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792710; BDBM706345; US20240383900, Compound PPA-007 CC(C)c1cnn2c(NCc3ccc(-c4ncccn4)cc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C26H32N8O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-GBZQ2Q US20240383900, Compound PPA-008 (3R,4R)-4-[[[3-propan-2-yl-7-[(4-pyrimidin-4-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792713; BDBM706346; US20240383900, Compound PPA-008 CC(C)c1cnn2c(NCc3ccc(-c4ccncn4)cc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C26H32N8O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-IE9I5K US20240383900, Compound PPA-009 (3R,4R)-4-[[[3-cyclopropyl-7-[(4-pyrazol-1-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792393; BDBM706347; US20240383900, Compound PPA-009 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-n3cccn3)cc2)n2ncc(C3CC3)c2n1 Degrader C25H30N8O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-JZWMCH US20240383900, Compound PPA-010 5-[[(3R,4R)-3-hydroxypiperidin-4-yl]methylamino]-7-[(4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile\; SCHEMBL24792387; BDBM706348; US20240383900, Compound PPA-010 N#Cc1cnn2c(NCc3ccc(-c4ccccn4)cc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C25H26N8O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-A58J0A US20240383900, Compound PPA-011 (3R,4R)-4-[[[7-[(3-methyl-4-pyridin-2-ylphenyl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792384; BDBM706349; US20240383900, Compound PPA-011 Cc1cc(CNc2cc(NC[C@H]3CCNC[C@@H]3O)nc3c(C(C)C)cnn23)ccc1-c1ccccn1 Degrader C28H35N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-VB6UZT US20240383900, Compound PPA-012 (3R,4R)-4-[[[7-[[4-(3-methylpyridin-2-yl)phenyl]methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792385; BDBM706350; US20240383900, Compound PPA-012 Cc1cccnc1-c1ccc(CNc2cc(NC[C@H]3CCNC[C@@H]3O)nc3c(C(C)C)cnn23)cc1 Degrader C28H35N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-HK4INB US20240383900, Compound PPA-013 (3R,4R)-4-[[[7-[[4-(3-methoxypyridin-2-yl)phenyl]methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792772; BDBM706351; US20240383900, Compound PPA-013 COc1cccnc1-c1ccc(CNc2cc(NC[C@H]3CCNC[C@@H]3O)nc3c(C(C)C)cnn23)cc1 Degrader C28H35N7O2 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-RKCL42 US20240383900, Compound PPA-014 (3R,4R)-4-[[[7-[[4-(3-fluoropyridin-2-yl)phenyl]methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792775; BDBM706352; US20240383900, Compound PPA-014 CC(C)c1cnn2c(NCc3ccc(-c4ncccc4F)cc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 Degrader C27H32FN7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-AMVNK2 US20240383900, Compound PPA-015 (3R,4R)-4-[[[3-cyclopropyl-7-[(3-methoxy-4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24791439; BDBM706353; US20240383900, Compound PPA-015 COc1cc(CNc2cc(NC[C@H]3CCNC[C@@H]3O)nc3c(C4CC4)cnn23)ccc1-c1ccccn1 Degrader C28H33N7O2 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-FURCG4 US20240383900, Compound PPA-016 (3R,4R)-4-[[[3-chloro-7-[(4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792773; BDBM706354; US20240383900, Compound PPA-016 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ccccn3)cc2)n2ncc(Cl)c2n1 Degrader C24H26ClN7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-O4VWUP US20240383900, Compound PPA-017 (3R,4R)-4-[[[3-cyclopropyl-7-[(4-pyrrol-1-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792386; BDBM706355; US20240383900, Compound PPA-017 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-n3cccc3)cc2)n2ncc(C3CC3)c2n1 Degrader C26H31N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-NYDAVE US20240383900, Compound PPA-018 (3R,4R)-4-[[[3-cyclopropyl-7-[[4-(1,3-thiazol-2-yl)phenyl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792388; BDBM706356; US20240383900, Compound PPA-018 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3nccs3)cc2)n2ncc(C3CC3)c2n1 Degrader C25H29N7OS CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-UQH0Y0 US20240383900, Compound PPA-019 (3R,4R)-4-[[[3-cyclopropyl-7-[[4-(5-fluoropyridin-2-yl)phenyl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792389; BDBM706357; US20240383900, Compound PPA-019 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ccc(F)cn3)cc2)n2ncc(C3CC3)c2n1 Degrader C27H30FN7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-0YK9H6 US20240383900, Compound PPA-020 (3R,4R)-4-[[[3-cyclopropyl-7-[(2-fluoro-4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792392; BDBM706358; US20240383900, Compound PPA-020 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ccccn3)cc2F)n2ncc(C3CC3)c2n1 Degrader C27H30FN7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-WUXXCX US20240383900, Compound PPA-021 (3R,4R)-4-[[[3-cyclopropyl-7-[(5-pyridin-2-ylpyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792826; BDBM706359; US20240383900, Compound PPA-021 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ccccn3)cn2)n2ncc(C3CC3)c2n1 Degrader C26H30N8O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-CC4YLF SCHEMBL24792970 (3R,4R)-4-[[[3-cyclopropyl-7-[(3-fluoro-4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792970 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ccccn3)c(F)c2)n2ncc(C3CC3)c2n1 Degrader C27H30FN7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-QAWAFC US20240383900, Compound PPA-023 (3R,4R)-4-[[[3-cyclopropyl-7-[[4-(2-methylimidazol-1-yl)phenyl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; BDBM706361; US20240383900, Compound PPA-023 Cc1nccn1-c1ccc(CNc2cc(NC[C@H]3CCNC[C@@H]3O)nc3c(C4CC4)cnn23)cc1 Degrader C26H32N8O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-68R2Z3 US20240383900, Compound PPA-024 (3R,4R)-4-[[[3-cyclopropyl-7-[(1-methyl-4-pyridin-2-ylimidazol-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792989; BDBM706362; US20240383900, Compound PPA-024 Cn1cc(-c2ccccn2)nc1CNc1cc(NC[C@H]2CCNC[C@@H]2O)nc2c(C3CC3)cnn12 Degrader C25H31N9O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-9A75PG US20240383900, Compound PPA-025 (3R,4R)-4-[[[3-cyclopropyl-7-[(1-pyridin-2-ylimidazol-4-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; BDBM706363; US20240383900, Compound PPA-025 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2cn(-c3ccccn3)cn2)n2ncc(C3CC3)c2n1 Degrader C24H29N9O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-9ZYQGJ US20240383900, Compound PPA-026 (3R,4R)-4-[[[3-cyclopropyl-7-[(6-phenylpyridin-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24791465; BDBM706364; US20240383900, Compound PPA-026 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ccccc3)nc2)n2ncc(C3CC3)c2n1 Degrader C27H31N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-N4OB44 US20240383900, Compound PPA-027 (3R,4R)-4-[[[3-cyclopropyl-7-[[4-(3-methoxypyridin-2-yl)phenyl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24791460; BDBM706365; US20240383900, Compound PPA-027 COc1cccnc1-c1ccc(CNc2cc(NC[C@H]3CCNC[C@@H]3O)nc3c(C4CC4)cnn23)cc1 Degrader C28H33N7O2 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-6G7CSD US20240383900, Compound PPA-028 (3R,4R)-4-[[[3-cyclopropyl-7-[[4-[3-(trifluoromethoxy)pyridin-2-yl]phenyl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24791461; BDBM706366; US20240383900, Compound PPA-028 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ncccc3OC(F)(F)F)cc2)n2ncc(C3CC3)c2n1 Degrader C28H30F3N7O2 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-0V5P3V US20240383900, Compound PPA-029 (3R,4R)-4-[[[3-cyclopropyl-7-[(4-pyrimidin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24791462; BDBM706367; US20240383900, Compound PPA-029 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ncccn3)cc2)n2ncc(C3CC3)c2n1 Degrader C26H30N8O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-WUGL66 US20240383900, Compound PPA-030 (3R,4R)-4-[[[3-cyclopropyl-7-[(2-methoxy-4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792800; BDBM706368; US20240383900, Compound PPA-030 COc1cc(-c2ccccn2)ccc1CNc1cc(NC[C@H]2CCNC[C@@H]2O)nc2c(C3CC3)cnn12 Degrader C28H33N7O2 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-HT2CPY US20240383900, Compound PPA-031 (3R,4R)-4-[[[3-cyclopropyl-7-[[4-(1,3-oxazol-2-yl)phenyl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792802; BDBM706369; US20240383900, Compound PPA-031 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ncco3)cc2)n2ncc(C3CC3)c2n1 Degrader C25H29N7O2 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-KOTSOB US20240383900, Compound PPA-032 3-cyclopropyl-5-N-[[(2R)-morpholin-2-yl]methyl]-7-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidine-5,7-diamine\; SCHEMBL24792808; BDBM706370; US20240383900, Compound PPA-032 c1ccc(-c2ccc(CNc3cc(NC[C@H]4CNCCO4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C26H29N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-5BDDQU US20240383900, Compound PPA-033 3-cyclopropyl-5-morpholin-4-yl-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine\; SCHEMBL24791639; BDBM706371; US20240383900, Compound PPA-033 c1ccc(-c2ccc(CNc3cc(N4CCOCC4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C25H26N6O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-SS02MN US20240383900, Compound PPA-034 (3R,4R)-4-[[[3-cyclopropyl-7-[(5-phenylpyridin-2-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792804; BDBM706372; US20240383900, Compound PPA-034 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ccccc3)cn2)n2ncc(C3CC3)c2n1 Degrader C27H31N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-SZ86MN US20240383900, Compound PPA-035 (3R,4R)-4-[[[3-cyclopropyl-7-[[4-(1,3-thiazol-4-yl)phenyl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792806; BDBM706373; US20240383900, Compound PPA-035 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3cscn3)cc2)n2ncc(C3CC3)c2n1 Degrader C25H29N7OS CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-59C27V US20240383900, Compound PPA-036 (3R,4R)-4-[[[3-cyclopropyl-7-[[4-[3-(trifluoromethyl)pyridin-2-yl]phenyl]methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol\; SCHEMBL24792809; BDBM706374; US20240383900, Compound PPA-036 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccc(-c3ncccc3C(F)(F)F)cc2)n2ncc(C3CC3)c2n1 Degrader C28H30F3N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-JSIVUU US20240383900, Compound PPA-037 3-cyclopropyl-7-N-[(4-pyridin-2-ylphenyl)methyl]-5-N-[(3S)-pyrrolidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine\; SCHEMBL24791659; BDBM706375; US20240383900, Compound PPA-037 c1ccc(-c2ccc(CNc3cc(N[C@H]4CCNC4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C25H27N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-5917PL US20240383900, Compound PPA-038 3-cyclopropyl-5-piperazin-1-yl-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine\; SCHEMBL24792404; BDBM706376; US20240383900, Compound PPA-038 c1ccc(-c2ccc(CNc3cc(N4CCNCC4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C25H27N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-VO5ZUZ US20240383900, Compound PPA-039 3-cyclopropyl-5-N-methyl-5-N-piperidin-4-yl-7-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidine-5,7-diamine\; SCHEMBL24791665; BDBM706377; US20240383900, Compound PPA-039 CN(c1cc(NCc2ccc(-c3ccccn3)cc2)n2ncc(C3CC3)c2n1)C1CCNCC1 Degrader C27H31N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-YTBO8K US20240383900, Compound PPA-040 3-cyclopropyl-5-N-(piperidin-4-ylmethyl)-7-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidine-5,7-diamine\; SCHEMBL24791651; BDBM706378; US20240383900, Compound PPA-040 c1ccc(-c2ccc(CNc3cc(NCC4CCNCC4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C27H31N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-LFC0SX US20240383900, Compound PPA-041 3-cyclopropyl-5-N-[(3,3-difluoropiperidin-4-yl)methyl]-7-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidine-5,7-diamine\; SCHEMBL24792811; BDBM706379; US20240383900, Compound PPA-041 FC1(F)CNCCC1CNc1cc(NCc2ccc(-c3ccccn3)cc2)n2ncc(C3CC3)c2n1 Degrader C27H29F2N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-QPUJOW US20240383900, Compound PPA-042 3-cyclopropyl-5-(2,7-diazaspiro[3.5]nonan-2-yl)-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine\; SCHEMBL24792403; BDBM706380; US20240383900, Compound PPA-042 c1ccc(-c2ccc(CNc3cc(N4CC5(CCNCC5)C4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C28H31N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-I42O33 US20240383900, Compound PPA-043 3-cyclopropyl-7-N-[(4-pyridin-2-ylphenyl)methyl]-5-N-[(3R)-pyrrolidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine\; SCHEMBL24791683; BDBM706381; US20240383900, Compound PPA-043 c1ccc(-c2ccc(CNc3cc(N[C@@H]4CCNC4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C25H27N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-TAUSYD US20240383900, Compound PPA-044 3-cyclopropyl-5-N-[(3S)-piperidin-3-yl]-7-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidine-5,7-diamine\; SCHEMBL24791508; BDBM706382; US20240383900, Compound PPA-044 c1ccc(-c2ccc(CNc3cc(N[C@H]4CCCNC4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C26H29N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-NXGBYR US20240383900, Compound PPA-045 3-cyclopropyl-5-N-[(3R)-piperidin-3-yl]-7-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidine-5,7-diamine\; SCHEMBL24791510; BDBM706383; US20240383900, Compound PPA-045 c1ccc(-c2ccc(CNc3cc(N[C@@H]4CCCNC4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C26H29N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-I0KYTR US20240383900, Compound PPA-046 1-[4-[[[3-Cyclopropyl-7-[(4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-1-yl]ethanone\; SCHEMBL24792856; BDBM706384; US20240383900, Compound PPA-046 CC(=O)N1CCC(CNc2cc(NCc3ccc(-c4ccccn4)cc3)n3ncc(C4CC4)c3n2)CC1 Degrader C29H33N7O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-FAOA6H WO2022263604-A1_PPA-047 . C1=C(NCc2ccc(-c3ccccn3)cc2)n2ncc(C3CC3)c2NC1NC1CNC1 Degrader C24H27N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-BNN23D US20240383900, Compound PPA-048 3-cyclopropyl-5-N-piperidin-4-yl-7-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidine-5,7-diamine\; SCHEMBL24792971; BDBM706386; US20240383900, Compound PPA-048 c1ccc(-c2ccc(CNc3cc(NC4CCNCC4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C26H29N7 CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-GZ5S57 US20240383900, Compound PPA-049 5-(azetidin-3-yloxy)-3-cyclopropyl-N-[(4-pyridin-2-ylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine\; SCHEMBL24791488; BDBM706387; US20240383900, Compound PPA-049 c1ccc(-c2ccc(CNc3cc(OC4CNC4)nc4c(C5CC5)cnn34)cc2)nc1 Degrader C24H24N6O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-I7GJW1 US20240383900, Compound PPA-050 1-[3-Cyclopropyl-7-[(4-pyridin-2-ylphenyl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-4-ol\; SCHEMBL24791494; BDBM706388; US20240383900, Compound PPA-050 OC1CCN(c2cc(NCc3ccc(-c4ccccn4)cc3)n3ncc(C4CC4)c3n2)CC1 Degrader C26H28N6O CDK12;CDK7;CCNK Q9NYV4/P50613/O75909 DDB1 WO-2022263604-A1 TPD-0160HF WO2023025225-A1_1 4-(oxetan-3-yloxy)-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine FC(F)(F)c1cnc(NCc2ccc(-c3ccccn3)cc2)nc1OC1COC1 Degrader C20H17F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-MRFIVK 5-chloro-4-methoxy-N-[(4-pyridin-2-ylphenyl)methyl]pyrimidin-2-amine 0 COc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1Cl Degrader C17H15ClN4O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-4CQ6PO WO2023025225-A1_100 (1R,2R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]cyclohexan-1-ol O[C@@H]1CCCC[C@H]1Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C23H24F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-YUBZYR WO2023025225-A1_101 (3R,4R)-4-[[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]piperidin-3-ol O[C@H]1CNCC[C@@H]1CNc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C23H25F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-VPWZJ2 WO2023025225-A1_102 5-methylsulfanyl-4-(oxetan-3-yloxy)-N-[(4-pyridin-2-ylphenyl)methyl]pyrimidin-2-amine CSc1cnc(NCc2ccc(-c3ccccn3)cc2)nc1OC1COC1 Degrader C20H20N4O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-M3S1AU WO2023025225-A1_103 5-methylsulfinyl-4-(oxetan-3-yloxy)-N-[(4-pyridin-2-ylphenyl)methyl]pyrimidin-2-amine CS(=O)c1cnc(NCc2ccc(-c3ccccn3)cc2)nc1OC1COC1 Degrader C20H20N4O3S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-V0430M WO2023025225-A1_104 2-[[2-[(4-Pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propane-1,3-diol OCC(CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C20H20F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-GPZCVB WO2023025225-A1_105 (2R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propan-1-ol C[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C20H20F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-0OEQ7Y WO2023025225-A1_106 4-[(3R)-1-methylpyrrolidin-3-yl]oxy-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine CN1CC[C@@H](Oc2nc(NCc3ccc(-c4ccccn4)cc3)ncc2C(F)(F)F)C1 Degrader C22H22F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-QBCL18 WO2023025225-A1_107 4-[(3S)-1-methylpyrrolidin-3-yl]oxy-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine CN1CC[C@H](Oc2nc(NCc3ccc(-c4ccccn4)cc3)ncc2C(F)(F)F)C1 Degrader C22H22F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-F9G9GI WO2023025225-A1_108 [3-[4-[[[4-(Oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]phenyl]methanol OCc1cccc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H20F3N3O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-1RT46I WO2023025225-A1_109 4-(oxetan-3-yloxy)-N-[2-(4-pyridin-2-ylphenyl)propan-2-yl]-5-(trifluoromethyl)pyrimidin-2-amine CC(C)(Nc1ncc(C(F)(F)F)c(OC2COC2)n1)c1ccc(-c2ccccn2)cc1 Degrader C22H21F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-D85H27 WO2023025225-A1_11 4-(1-methylpyrazol-3-yl)-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine Cn1ccc(-c2nc(NCc3ccc(-c4ccccn4)cc3)ncc2C(F)(F)F)n1 Degrader C21H17F3N6 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-2M6RI2 WO2023025225-A1_110 4-(oxetan-3-yloxy)-N-[(1S)-1-(4-pyridin-2-ylphenyl)ethyl]-5-(trifluoromethyl)pyrimidin-2-amine C[C@H](Nc1ncc(C(F)(F)F)c(OC2COC2)n1)c1ccc(-c2ccccn2)cc1 Degrader C21H19F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-N7YQMR WO2023025225-A1_111 (1R,2R)-2-[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxycyclohexan-1-ol O[C@@H]1CCCC[C@H]1Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C23H23F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-E328RL WO2023025225-A1_112 N-[(2-methoxy-4-pyridin-2-ylphenyl)methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine COc1cc(-c2ccccn2)ccc1CNc1ncc(C(F)(F)F)c(OC2COC2)n1 Degrader C21H19F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-K0MSWX WO2023025225-A1_113 4-[[(2R)-1-hydroxybutan-2-yl]amino]-2-[(4-pyridin-2-ylphenyl)methylamino]pyrimidine-5-carboxamide CC[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(N)=O Degrader C21H24N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-A1JJVX WO2023025225-A1_114 N-[[4-(4-methoxypyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine COc1ccnc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C21H19F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-A6P802 WO2023025225-A1_115 . O[C@@H]1CCC[C@H]1Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C22H21F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-6T14AC WO2023025225-A1_116 (3R,4R)-4-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]pyrrolidin-3-ol O[C@@H]1CNC[C@H]1Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H21F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-MGBJWY WO2023025225-A1_117 N-[[4-(4-chloropyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine FC(F)(F)c1cnc(NCc2ccc(-c3cc(Cl)ccn3)cc2)nc1OC1COC1 Degrader C20H16ClF3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-INMVZR WO2023025225-A1_118 4-(oxetan-3-yloxy)-N-[[4-pyridin-2-yl-2-(trifluoromethyl)phenyl]methyl]-5-(trifluoromethyl)pyrimidin-2-amine FC(F)(F)c1cc(-c2ccccn2)ccc1CNc1ncc(C(F)(F)F)c(OC2COC2)n1 Degrader C21H16F6N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-G784RL WO2023025225-A1_119 4-(oxetan-3-yloxy)-N-[(1R)-1-(4-pyridin-2-ylphenyl)ethyl]-5-(trifluoromethyl)pyrimidin-2-amine C[C@@H](Nc1ncc(C(F)(F)F)c(OC2COC2)n1)c1ccc(-c2ccccn2)cc1 Degrader C21H19F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-9SFN4Q WO2023025225-A1_12 N-[[4-(2-methoxyphenyl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine COc1ccccc1-c1ccc(CNc2ncc(C(F)(F)F)c(OC3COC3)n2)cc1 Degrader C22H20F3N3O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-7FT5BT WO2023025225-A1_120 (1R,2R)-2-[[2-[(5-pyridin-2-ylpyridin-2-yl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]cyclopentan-1-ol O[C@@H]1CCC[C@H]1Nc1nc(NCc2ccc(-c3ccccn3)cn2)ncc1C(F)(F)F Degrader C21H21F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-UBUGMI WO2023025225-A1_121 (2R)-2-[[2-[(5-pyridin-2-ylpyridin-2-yl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butan-1-ol CC[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cn2)ncc1C(F)(F)F Degrader C20H21F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-1XMUE9 WO2023025225-A1_122 N-[[4-(4,6-dimethylpyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine Cc1cc(C)nc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H21F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-L9ZIDY WO2023025225-A1_123 2-Methyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propan-1-ol CC(C)(CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H22F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-UV3VK8 WO2023025225-A1_124 (3R)-3-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]pyrrolidin-2-one O=C1NCC[C@H]1Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H19F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-DGL70I WO2023025225-A1_125 [2-(Hydroxymethyl)-6-[4-[[[4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]pyridin-4-yl]methanol OCc1cc(CO)nc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H21F3N4O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-A42TF0 WO2023025225-A1_126 (2R,3R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butane-1,3-diol C[C@@H](O)[C@@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H22F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-FGEXO7 WO2023025225-A1_128 N-[[4-(4-cyclopropylpyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine FC(F)(F)c1cnc(NCc2ccc(-c3cc(C4CC4)ccn3)cc2)nc1OC1COC1 Degrader C23H21F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-1DG02I WO2023025225-A1_129 N-[[4-(4-ethenylpyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine C=Cc1ccnc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H19F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-NCSQTZ WO2023025225-A1_13 4-(5-methylsulfonylpyridin-3-yl)-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine CS(=O)(=O)c1cncc(-c2nc(NCc3ccc(-c4ccccn4)cc3)ncc2C(F)(F)F)c1 Degrader C23H18F3N5O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-7K446N WO2023025225-A1_130 (2S,3S)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butane-1,3-diol C[C@H](O)[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H22F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-UETUKM WO2023025225-A1_131 (2R,3R)-3-[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxybutan-2-ol C[C@@H](O)[C@@H](C)Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H21F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-F4UVO0 WO2023025225-A1_132 (2S)-3-hydroxy-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propanamide NC(=O)[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C20H19F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-HOH42F WO2023025225-A1_133 N-[(2-chloro-4-pyridin-2-ylphenyl)methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine FC(F)(F)c1cnc(NCc2ccc(-c3ccccn3)cc2Cl)nc1OC1COC1 Degrader C20H16ClF3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-2L8WOK WO2023025225-A1_134 (2R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide CC[C@@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C21H21F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-5BX08Y WO2023025225-A1_135 N-[[4-(4-ethylpyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine CCc1ccnc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H21F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-9S2Y02 WO2023025225-A1_136 N-[(1R)-2-methyl-1-(4-pyridin-2-ylphenyl)propyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine CC(C)[C@@H](Nc1ncc(C(F)(F)F)c(OC2COC2)n1)c1ccc(-c2ccccn2)cc1 Degrader C23H23F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-YPBAXO WO2023025225-A1_137 N-[(R)-cyclopropyl-(4-pyridin-2-ylphenyl)methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine FC(F)(F)c1cnc(N[C@@H](c2ccc(-c3ccccn3)cc2)C2CC2)nc1OC1COC1 Degrader C23H21F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-XOLR97 WO2023025225-A1_138 . N#Cc1ccnc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C21H16F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-04ESY5 WO2023025225-A1_139 N-[[4-(4-dimethylphosphorylpyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine CP(C)(=O)c1ccnc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H22F3N4O3P CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-04AZAC WO2023025225-A1_14 4-Phenoxy-2-[(4-pyridin-2-ylphenyl)methylamino]pyrimidine-5-carbonitrile N#Cc1cnc(NCc2ccc(-c3ccccn3)cc2)nc1Oc1ccccc1 Degrader C23H17N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-PKJIDN WO2023025225-A1_140 N-[(1S)-2-methyl-1-(4-pyridin-2-ylphenyl)propyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine CC(C)[C@H](Nc1ncc(C(F)(F)F)c(OC2COC2)n1)c1ccc(-c2ccccn2)cc1 Degrader C23H23F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-50W055 WO2023025225-A1_141 6-[4-[[[4-(Oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]pyridine-2-carbonitrile N#Cc1cccc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)n1 Degrader C21H16F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-VJLNPQ WO2023025225-A1_142 4-(oxetan-3-yloxy)-N-[(1R)-1-(4-pyridin-2-ylphenyl)propyl]-5-(trifluoromethyl)pyrimidin-2-amine CC[C@@H](Nc1ncc(C(F)(F)F)c(OC2COC2)n1)c1ccc(-c2ccccn2)cc1 Degrader C22H21F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-1OM20Z WO2023025225-A1_143 . FC(F)(F)c1ccnc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C21H16F6N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-CMTSRX WO2023025225-A1_144 . COc1cc(CO)nc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H21F3N4O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-F7ZGBQ WO2023025225-A1_145 . COCc1ccnc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H21F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-3UEDWO WO2023025225-A1_146 4-(3-methylsulfonylphenyl)-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine CS(=O)(=O)c1cccc(-c2nc(NCc3ccc(-c4ccccn4)cc3)ncc2C(F)(F)F)c1 Degrader C24H19F3N4O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-UUP39M WO2023025225-A1_147 . NS(=O)(=O)c1cccc(-c2nc(NCc3ccc(-c4ccccn4)cc3)ncc2C(F)(F)F)c1 Degrader C23H18F3N5O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-N38KV6 WO2023025225-A1_148 N-[[4-(6-methoxypyrimidin-4-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine COc1cc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)ncn1 Degrader C20H18F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-VV0DDQ WO2023025225-A1_149 (2R)-2-[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxybutan-1-ol CC[C@H](CO)Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H21F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-IDMIGN WO2023025225-A1_15 N-[[4-(6-methylpyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine Cc1cccc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)n1 Degrader C21H19F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-A9Y7QC WO2023025225-A1_150 . O[C@H]1CCCC[C@H]1Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C23H23F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-9GPKQ7 WO2023025225-A1_151 (3S,4R)-4-[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxyoxolan-3-ol O[C@H]1COC[C@H]1Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H19F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-PXDX1P WO2023025225-A1_154 4-pyridin-3-yloxy-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine FC(F)(F)c1cnc(NCc2ccc(-c3ccccn3)cc2)nc1Oc1cccnc1 Degrader C22H16F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-8L1XZQ WO2023025225-A1_155 4-(5-methylsulfonylpyridin-3-yl)oxy-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine CS(=O)(=O)c1cncc(Oc2nc(NCc3ccc(-c4ccccn4)cc3)ncc2C(F)(F)F)c1 Degrader C23H18F3N5O3S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-EYO1GS WO2023025225-A1_156 (1S,2R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]cyclohexan-1-ol O[C@H]1CCCC[C@H]1Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C23H24F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-ROF4ID WO2023025225-A1_157 4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine C[C@@H]1CN(c2nc(NCc3ccc(-c4ccccn4)cc3)ncc2C(F)(F)F)C[C@H](C)N1 Degrader C23H25F3N6 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-RH1R8R WO2023025225-A1_158 (2S)-3-methoxy-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propan-1-ol COC[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H22F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-78BAPT WO2023025225-A1_159 (2R)-2-cyclopropyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]ethanol OC[C@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C1CC1 Degrader C22H22F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-OIPU47 WO2023025225-A1_16 4-(oxetan-3-yloxy)-5-(trifluoromethyl)-N-[[4-[6-(trifluoromethyl)pyridin-2-yl]phenyl]methyl]pyrimidin-2-amine FC(F)(F)c1cccc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)n1 Degrader C21H16F6N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-5D78JP WO2023025225-A1_160 (2R,3R)-2-[[2-[[4-[4-(hydroxymethyl)-6-methylpyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butane-1,3-diol Cc1cc(CO)cc(-c2ccc(CNc3ncc(C(F)(F)F)c(N[C@H](CO)[C@@H](C)O)n3)cc2)n1 Degrader C23H26F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-0R2QPW WO2023025225-A1_161 (2R)-2-[[2-[[4-[4-(hydroxymethyl)-6-methylpyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide CC[C@@H](Nc1nc(NCc2ccc(-c3cc(CO)cc(C)n3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C23H25F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-4HRGVX WO2023025225-A1_162 (2R,3R)-2-[[2-[[4-[6-(hydroxymethyl)-4-methylpyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butane-1,3-diol Cc1cc(CO)nc(-c2ccc(CNc3ncc(C(F)(F)F)c(N[C@H](CO)[C@@H](C)O)n3)cc2)c1 Degrader C23H26F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-EBGNIN WO2023025225-A1_163 (2R)-2-[[2-[[4-[6-(hydroxymethyl)-4-methylpyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide CC[C@@H](Nc1nc(NCc2ccc(-c3cc(C)cc(CO)n3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C23H25F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-RB7CX5 WO2023025225-A1_164 . O[C@H]1CNC[C@H]1Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H20F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-LEM1SC WO2023025225-A1_165 (2R)-2-[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxypropan-1-ol C[C@H](CO)Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C20H19F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-6WG5F3 WO2023025225-A1_166 (2R)-2-[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxypropanamide C[C@@H](Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C20H18F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-HEDOJB WO2023025225-A1_167 (3R)-2-methyl-3-[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxybutan-2-ol C[C@@H](Oc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C(C)(C)O Degrader C22H23F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-T7U9MI WO2023025225-A1_168 (2R,3R)-3-[2-[[4-[4,6-bis(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxybutan-2-ol C[C@@H](O)[C@@H](C)Oc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cc2)ncc1C(F)(F)F Degrader C23H25F3N4O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-ZW99BX WO2023025225-A1_169 (2R)-2-[[2-[[4-[4,6-bis(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide CC[C@@H](Nc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C23H25F3N6O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-KIXEGG WO2023025225-A1_17 N-[[4-(6-methoxypyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine COc1cccc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)n1 Degrader C21H19F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-S0UAJK WO2023025225-A1_170 (2R,3R)-2-[[2-[[4-[4,6-bis(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butane-1,3-diol C[C@@H](O)[C@@H](CO)Nc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cc2)ncc1C(F)(F)F Degrader C23H26F3N5O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-LO9SFX WO2023025225-A1_171 (2R,3R)-2-[[2-[[4-[6-(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butane-1,3-diol C[C@@H](O)[C@@H](CO)Nc1nc(NCc2ccc(-c3cccc(CO)n3)cc2)ncc1C(F)(F)F Degrader C22H24F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-8PCD69 WO2023025225-A1_172 (2R)-2-[[2-[[4-[6-(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide CC[C@@H](Nc1nc(NCc2ccc(-c3cccc(CO)n3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C22H23F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-2FEHP1 WO2023025225-A1_173 (2R,3R)-3-[2-[[4-[6-(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxybutan-2-ol C[C@@H](O)[C@@H](C)Oc1nc(NCc2ccc(-c3cccc(CO)n3)cc2)ncc1C(F)(F)F Degrader C22H23F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-4JWCO4 WO2023025225-A1_174 (2R)-2-[[2-[[4-[4,6-bis(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-5-cyanopyrimidin-4-yl]amino]butanamide CC[C@@H](Nc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cc2)ncc1C#N)C(N)=O Degrader C23H25N7O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-03E7QO WO2023025225-A1_175 2-[[4-[4,6-bis(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-4-[[(2R,3R)-1,3-dihydroxybutan-2-yl]amino]pyrimidine-5-carbonitrile C[C@@H](O)[C@@H](CO)Nc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cc2)ncc1C#N Degrader C23H26N6O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-3D16PI WO2023025225-A1_176 (2R)-2-[[2-[[5-[4,6-bis(hydroxymethyl)pyridin-2-yl]pyridin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide CC[C@@H](Nc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cn2)ncc1C(F)(F)F)C(N)=O Degrader C22H24F3N7O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-W66ADM WO2023025225-A1_177 (2R,3R)-2-[[2-[[5-[4,6-bis(hydroxymethyl)pyridin-2-yl]pyridin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butane-1,3-diol C[C@@H](O)[C@@H](CO)Nc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cn2)ncc1C(F)(F)F Degrader C22H25F3N6O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-2JQ5MX WO2023025225-A1_178 4-(Hydroxymethyl)-6-[4-[[[4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]pyridine-2-carbonitrile N#Cc1cc(CO)cc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)n1 Degrader C22H18F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-TYZUBI WO2023025225-A1_179 . N#Cc1cc(CO)nc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H18F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-M5B3KS WO2023025225-A1_18 [6-[4-[[[4-(Oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]pyridin-2-yl]methanol OCc1cccc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)n1 Degrader C21H19F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-6FKCBB WO2023025225-A1_180 2-(Hydroxymethyl)-6-[4-[[[4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]pyridine-4-carboxamide NC(=O)c1cc(CO)nc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H20F3N5O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-EZ4RJM WO2023025225-A1_181 [2-(hydroxymethyl)-6-[4-[(1R)-1-[[4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]ethyl]phenyl]pyridin-4-yl]methanol C[C@@H](Nc1ncc(C(F)(F)F)c(OC2COC2)n1)c1ccc(-c2cc(CO)cc(CO)n2)cc1 Degrader C23H23F3N4O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-GDW18E WO2023025225-A1_182 (2R,3R)-3-[2-[[5-[4,6-bis(hydroxymethyl)pyridin-2-yl]pyridin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxybutan-2-ol C[C@@H](O)[C@@H](C)Oc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cn2)ncc1C(F)(F)F Degrader C22H24F3N5O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-BFHRY8 WO2023025225-A1_183 (2R,3R)-3-[2-[[4-[5-(hydroxymethyl)pyridin-3-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]oxybutan-2-ol C[C@@H](O)[C@@H](C)Oc1nc(NCc2ccc(-c3cncc(CO)c3)cc2)ncc1C(F)(F)F Degrader C22H23F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-XA6JTJ WO2023025225-A1_184 (2R,3R)-3-[2-[[(1R)-1-[4-[4,6-bis(hydroxymethyl)pyridin-2-yl]phenyl]ethyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]oxybutan-2-ol C[C@@H](Nc1ncc(C(F)(F)F)c(O[C@H](C)[C@@H](C)O)n1)c1ccc(-c2cc(CO)cc(CO)n2)cc1 Degrader C24H27F3N4O4 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-OS6BZA WO2023025225-A1_185 [(2S)-1-[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]pyrrolidin-2-yl]methanol OC[C@@H]1CCCN1c1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C22H22F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-UIDHJI WO2023025225-A1_186 (2R)-1-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propan-2-ol C[C@@H](O)CNc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C20H20F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-PWOI53 WO2023025225-A1_187 (3R,5S)-5-(hydroxymethyl)-1-[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]pyrrolidin-3-ol OC[C@@H]1C[C@@H](O)CN1c1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C22H22F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-4FCCFG WO2023025225-A1_188 (2R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propanamide C[C@@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C20H19F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-YN32QW WO2023025225-A1_189 [4-(Aminomethyl)-6-[4-[[[4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]pyridin-2-yl]methanol NCc1cc(CO)nc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H22F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-RSC3HF WO2023025225-A1_19 4-(oxetan-3-yloxy)-N-[(4-pyrimidin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine FC(F)(F)c1cnc(NCc2ccc(-c3ncccn3)cc2)nc1OC1COC1 Degrader C19H16F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-OJJ4AN WO2023025225-A1_190 (2S,3R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butane-1,3-diol C[C@@H](O)[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H22F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-0QN6DW WO2023025225-A1_191 (2R,3S)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butane-1,3-diol C[C@H](O)[C@@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H22F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-91GNSF WO2023025225-A1_192 (2R)-N,N-dimethyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propanamide C[C@@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C(=O)N(C)C Degrader C22H23F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-E8MXNF WO2023025225-A1_193 (2R)-N-methyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propanamide CNC(=O)[C@@H](C)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H21F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-TR43RJ WO2023025225-A1_194 (2R,3R)-3-[[2-[[4-[4,6-bis(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butan-2-ol C[C@@H](O)[C@@H](C)Nc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cc2)ncc1C(F)(F)F Degrader C23H26F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-0UUH3C WO2023025225-A1_195 (2R,3R)-3-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]pentan-2-ol CC[C@@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)[C@@H](C)O Degrader C22H24F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-449ZFM WO2023025225-A1_196 (1R,2R)-1-cyclopropyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propan-1-ol C[C@@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)[C@H](O)C1CC1 Degrader C23H24F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-VDDGHN WO2023025225-A1_197 (1S,2R)-1-cyclopropyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propan-1-ol C[C@@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)[C@@H](O)C1CC1 Degrader C23H24F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-EOAB1A WO2023025225-A1_198 (2R,3R)-3-[[2-[[4-[4,6-bis(hydroxymethyl)pyridin-2-yl]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]pentan-2-ol CC[C@@H](Nc1nc(NCc2ccc(-c3cc(CO)cc(CO)n3)cc2)ncc1C(F)(F)F)[C@@H](C)O Degrader C24H28F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-QNNVXK WO2023025225-A1_199 (2R,3S)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]pentan-3-ol CC[C@H](O)[C@@H](C)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C22H24F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-R7SVYC WO2023025225-A1_2 5-chloro-4-(1H-indol-3-yl)-N-[(4-pyridin-2-ylphenyl)methyl]pyrimidin-2-amine Clc1cnc(NCc2ccc(-c3ccccn3)cc2)nc1-c1c[nH]c2ccccc12 Degrader C24H18ClN5 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-3MHUT1 WO2023025225-A1_20 N-[(3-methoxy-4-pyridin-2-ylphenyl)methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine COc1cc(CNc2ncc(C(F)(F)F)c(OC3COC3)n2)ccc1-c1ccccn1 Degrader C21H19F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-65Q1G8 WO2023078410-A1_1-86 . CN(C(=O)OC(C)(C)C)[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCCCC1 Degrader C28H38N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-BEFNZO WO2023078410-A1_1-89 . CCN(C(=O)OC(C)(C)C)[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCCCC1 Degrader C29H40N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-UGE827 SCHEMBL26147336 tert-butyl N-[(1R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147336 CC(C)(C)OC(=O)N[C@@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C27H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-VEHCN7 SCHEMBL25169570 tert-butyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]amino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL25169570 CC(C)(C)OC(=O)N[C@H](C(=O)Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C26H28N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-VV0A2H SCHEMBL26147327 N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]benzamide\; SCHEMBL26147327 O=C1CCC(N2Cc3cc(CNC(=O)C(NC(=O)c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C29H26N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-K6ZQRQ SCHEMBL25167514 (2S)-2-acetamido-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-phenylacetamide\; SCHEMBL25167514 CC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C24H24N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-HVD0H1 SCHEMBL26147411 tert-butyl N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxoethyl]carbamate\; SCHEMBL26147411 CC(C)(C)OC(=O)NCC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C21H26N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-KMMEJ5 SCHEMBL25173088 tert-butyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]amino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL25173088 CC(C)(C)OC(=O)N[C@H](C(=O)Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C26H28N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-51J9BK SCHEMBL26147328 methyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147328 COC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C24H24N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-A097VJ SCHEMBL25167518 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-(methylamino)-2-phenylacetamide\; SCHEMBL25167518 CNC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C23H24N4O4 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-9X6CFO SCHEMBL26147412 tert-butyl N-[(2R)-1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-4-methyl-1-oxopentan-2-yl]carbamate\; SCHEMBL26147412 CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C25H34N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-ENJL1K SCHEMBL26147413 tert-butyl N-[1-cyclohexyl-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxoethyl]carbamate\; SCHEMBL26147413 CC(C)(C)OC(=O)NC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCCCC1 Degrader C27H36N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-WBKLUS SCHEMBL26147330 methyl N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147330 COC(=O)NC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C24H24N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-6KZCDW SCHEMBL25175364 2-(tert-butylcarbamoylamino)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-phenylacetamide\; SCHEMBL25175364 CC(C)(C)NC(=O)NC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C27H31N5O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-USLWD1 SCHEMBL26147345 tert-butyl N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147345 CC(C)(C)OC(=O)NC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C27H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-34YHU6 SCHEMBL26147369 N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]morpholine-4-carboxamide\; SCHEMBL26147369 O=C1CCC(N2Cc3cc(CNC(=O)C(NC(=O)N4CCOCC4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C27H29N5O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-8UDVWK SCHEMBL26147231 tert-butyl N-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxo-1-phenylpropyl]carbamate\; SCHEMBL26147231 CC(C)(C)OC(=O)NC(CC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C28H32N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-677SKI SCHEMBL26147473 tert-butyl N-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxo-2-phenylpropyl]carbamate\; SCHEMBL26147473 CC(C)(C)OC(=O)NCC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C28H32N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-0HM419 SCHEMBL26148700 tert-butyl N-[(2R)-1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-1-oxo-3-phenylpropan-2-yl]carbamate\; SCHEMBL26148700 CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C28H32N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-LJ4VQ2 WO2023078410-A1_4-133 . CC(C)(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)CC1=O)C2=O)c1ccc2ccccc2c1 Degrader C32H33N3O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-EBVNUZ SCHEMBL26147415 tert-butyl 1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylcarbamoyl]-1,3-dihydroisoindole-2-carboxylate\; SCHEMBL26147415 CC(C)(C)OC(=O)N1Cc2ccccc2C1C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C28H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-S0E7ON SCHEMBL26147758 tert-butyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]-N-methylcarbamate\; SCHEMBL26147758 CN(C(=O)OC(C)(C)C)[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C28H32N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-TVMZU7 SCHEMBL26147433 tert-butyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-1-(4-fluorophenyl)-2-oxoethyl]carbamate\; SCHEMBL26147433 CC(C)(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccc(F)cc1 Degrader C27H29FN4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-W9OUT1 SCHEMBL26147468 tert-butyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-1-(4-hydroxyphenyl)-2-oxoethyl]carbamate\; SCHEMBL26147468 CC(C)(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccc(O)cc1 Degrader C27H30N4O7 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-V3VU9H SCHEMBL26147331 ethyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147331 CCOC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C25H26N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-8YUFDZ SCHEMBL26147349 benzyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147349 O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NC(=O)OCc4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C30H28N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-D7LO0R SCHEMBL26147437 tert-butyl N-[(1S)-1-(3-chlorophenyl)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxoethyl]carbamate\; SCHEMBL26147437 CC(C)(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1cccc(Cl)c1 Degrader C27H29ClN4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-DQ1SOA SCHEMBL26147438 tert-butyl N-[(1S)-1-(4-chlorophenyl)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxoethyl]carbamate\; SCHEMBL26147438 CC(C)(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccc(Cl)cc1 Degrader C27H29ClN4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-PBXU1Y SCHEMBL26147178 tert-butyl N-[1-(3,4-dichlorophenyl)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxoethyl]carbamate\; SCHEMBL26147178 CC(C)(C)OC(=O)NC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccc(Cl)c(Cl)c1 Degrader C27H28Cl2N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-WLOLNO WO2023078410-A1_4-152 . CC(C)(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccc(F)c(Cl)c1 Degrader C27H28ClFN4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-6BSZ29 SCHEMBL26147394 tert-butyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147394 CC(C)(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2)c1ccccc1 Degrader C27H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-T6047L SCHEMBL26147370 N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]-3,3-dimethylbutanamide\; SCHEMBL26147370 CC(C)(C)CC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C28H32N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-NFKBVM SCHEMBL26147346 cyclopentyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147346 O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NC(=O)OC4CCCC4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C28H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-LWZEED SCHEMBL26147333 propan-2-yl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147333 CC(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C26H28N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-M5IPL1 SCHEMBL25172860 (2S)-2-[(2-cyclopropylacetyl)amino]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-phenylacetamide\; SCHEMBL25172860 O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NC(=O)CC4CC4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C27H28N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-LVADC6 SCHEMBL26147471 tert-butyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-1-(4-methylphenyl)-2-oxoethyl]carbamate\; SCHEMBL26147471 Cc1ccc([C@H](NC(=O)OC(C)(C)C)C(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1 Degrader C28H32N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-YS6Z5N SCHEMBL26147410 tert-butyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-4-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147410 CC(C)(C)OC(=O)N[C@H](C(=O)NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2)c1ccccc1 Degrader C27H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-ZBKXFZ SCHEMBL26147512 tert-butyl N-[(2R)-2-benzyl-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxopropyl]carbamate\; SCHEMBL26147512 CC(C)(C)OC(=O)NC[C@@H](Cc1ccccc1)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C29H34N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-MYF8BV SCHEMBL26147351 (2S)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[(2-phenoxyacetyl)amino]-2-phenylacetamide\; SCHEMBL26147351 O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NC(=O)COc4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C30H28N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-QA0V78 WO2023078410-A1_4-175 . CC(C)[C@H]1CC[C@H](C)C[C@@H]1OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C33H40N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-WW9K78 WO2023078410-A1_4-175b . CC(C)C1CC[C@@H](C)C[C@H]1OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C33H40N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-E4F909 SCHEMBL25175866 (2S)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[(4-methylphenyl)sulfonylamino]-2-phenylacetamide\; SCHEMBL25175866 Cc1ccc(S(=O)(=O)N[C@H](C(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c2ccccc2)cc1 Degrader C29H28N4O6S GSPT1 P15170 CRBN WO-2023078410-A1 TPD-GCGQGF WO2023078410-A1_4-177 . O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NS(=O)(=O)C4CC4)c4ccccc4)ccc3C2=O)C(=O)C1 Degrader C26H27N3O6S GSPT1 P15170 CRBN WO-2023078410-A1 TPD-LVP3LW SCHEMBL26147350 (2S)-2-[(2-cyclopentyloxyacetyl)amino]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-phenylacetamide\; SCHEMBL26147350 O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NC(=O)COC4CCCC4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C29H32N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-RI0OBT SCHEMBL25169582 (2S)-2-(benzylcarbamoylamino)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-phenylacetamide\; SCHEMBL25169582 O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NC(=O)NCc4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C30H29N5O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-17W8UL SCHEMBL26147513 2-[[2-(tert-butylamino)-2-oxoethyl]amino]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-phenylpropanamide\; SCHEMBL26147513 CC(C)(C)NC(=O)CNC(Cc1ccccc1)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C29H35N5O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-RWV1UB WO2023078410-A1_4-187 . CC(C)(C)CC(=O)NCC(Cc1ccccc1)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C30H36N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-TA8OBN SCHEMBL25172646 2-benzyl-3-(tert-butylcarbamoylamino)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]propanamide\; SCHEMBL25172646 CC(C)(C)NC(=O)NCC(Cc1ccccc1)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C29H35N5O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-0ILUO2 SCHEMBL26147541 N-[2-benzyl-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxopropyl]cyclopentanecarboxamide\; SCHEMBL26147541 O=C1CCC(N2Cc3cc(CNC(=O)C(CNC(=O)C4CCCC4)Cc4ccccc4)ccc3C2=O)C(=O)N1 Degrader C30H34N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-CG4NWX SCHEMBL26147389 (2S)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[(2-hydroxy-2-phenylacetyl)amino]-2-phenylacetamide\; SCHEMBL26147389 O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NC(=O)C(O)c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C30H28N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-LPH9K8 SCHEMBL26147393 2-acetamido-N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]-2-phenylacetamide\; SCHEMBL26147393 CC(=O)NC(C(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1)c1ccccc1 Degrader C32H31N5O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-7BRWJG SCHEMBL26147348 phenyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147348 O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NC(=O)Oc4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C29H26N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-INJR7H SCHEMBL26147392 N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]-2-(methylamino)-2-phenylacetamide\; SCHEMBL26147392 CNC(C(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1)c1ccccc1 Degrader C31H31N5O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-AGX89R SCHEMBL26147371 N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]-2-hydroxy-3-methylbutanamide\; SCHEMBL26147371 CC(C)C(O)C(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C27H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-SU4BES SCHEMBL26147391 (2S)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[(2-oxo-2-phenylacetyl)amino]-2-phenylacetamide\; SCHEMBL26147391 O=C1CCC(N2Cc3cc(CNC(=O)[C@@H](NC(=O)C(=O)c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C30H26N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-35XKVO SCHEMBL26147390 (2S)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-[(2-methoxy-2-phenylacetyl)amino]-2-phenylacetamide\; SCHEMBL26147390 COC(C(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1)c1ccccc1 Degrader C31H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-CB1YHK SCHEMBL26147435 tert-butyl N-[1-(2-chlorophenyl)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxoethyl]carbamate\; SCHEMBL26147435 CC(C)(C)OC(=O)NC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1Cl Degrader C27H29ClN4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-7WTITP SCHEMBL26147507 tert-butyl 2-[[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]amino]acetate\; SCHEMBL26147507 CC(C)(C)OC(=O)CN[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C28H32N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-IWBS09 SCHEMBL25175860 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-hydroxy-2-phenylacetamide\; SCHEMBL25175860 O=C1CCC(N2Cc3cc(CNC(=O)C(O)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C22H21N3O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-PQR4T2 SCHEMBL25169584 (2S)-2-amino-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-phenylacetamide\; SCHEMBL25169584 N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C22H22N4O4 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-VZ7FM2 SCHEMBL26147334 tert-butyl N-[(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]carbamate\; SCHEMBL26147334 CC(C)(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C27H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-10IZT8 SCHEMBL26147545 phenyl N-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxo-2-phenylpropyl]carbamate\; SCHEMBL26147545 O=C1CCC(N2Cc3cc(CNC(=O)C(CNC(=O)Oc4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C30H28N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-2RLKY7 SCHEMBL25175141 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-phenyl-3-(phenylcarbamoylamino)propanamide\; SCHEMBL25175141 O=C1CCC(N2Cc3cc(CNC(=O)C(CNC(=O)Nc4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C30H29N5O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-I7GILX SCHEMBL26147599 3-(tert-butylcarbamoylamino)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-phenylpropanamide\; SCHEMBL26147599 CC(C)(C)NC(=O)NCC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C28H33N5O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-TM8077 SCHEMBL25344073 3-[5-[4-(1-Adamantylamino)butylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344073 Cc1nc2cccc(NCCCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C28H37N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-FCP2GR US20240425475, Compound GT-02234 3-[5-[2-[2-(1-Adamantylamino)ethoxy]ethylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; BDBM708503; US20240425475, Compound GT-02234; 3-(5-((2-(2-(((1s,3s)-adamantan-1- yl)amino)ethoxy)ethyl)amino)- 2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione Cc1nc2cccc(NCCOCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C28H37N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-C1TA2E SCHEMBL25346262 3-[5-[6-(1-Adamantylamino)hexylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346262 Cc1nc2cccc(NCCCCCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C30H41N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-EIAYD0 US20240425475, Compound GT-02237 3-[5-[7-(1-Adamantylamino)heptylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; BDBM708492; US20240425475, Compound GT-02237; 3-(5-((7-(((1s,3s)-adamantan-1- yl)amino)heptyl)amino)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione Cc1nc2cccc(NCCCCCCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C31H43N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-VFYX60 SCHEMBL25346527 3-[5-[2-[2-[2-(1-Adamantylamino)ethoxy]ethoxy]ethylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346527 Cc1nc2cccc(NCCOCCOCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C30H41N5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-MU0B11 WO2023151635-A1_GT-02280 3-[5-[5-(1-Adamantylamino)pentylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione Cc1nc2cccc(NCCCCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C29H39N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-ZJMPIP SCHEMBL29085646 N-[5-[[3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxoquinazolin-5-yl]amino]pentyl]adamantane-1-carboxamide\; SCHEMBL29085646 Cc1nc2cccc(NCCCCCNC(=O)C34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C30H39N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-J4KSK2 SCHEMBL25345699 3-[5-[2-(2-Adamantylamino)ethylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25345699; SCHEMBL25345706 Cc1nc2cccc(NCCNC3C4CC5CC(C4)CC3C5)c2c(=O)n1C1CCC(=O)NC1=O Degrader C26H33N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-S2FTJC BDBM708494 3-[5-[3-(2-Adamantylamino)propylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344961; SCHEMBL25344965; BDBM708494; US20240425475, Compound GT-02326; 3-(5-((3-(((1r,3r, 5r,7r)-adamantan-2- yl)amino)propyl) amino)-2-methyl-4- oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione Cc1nc2cccc(NCCCNC3C4CC5CC(C4)CC3C5)c2c(=O)n1C1CCC(=O)NC1=O Degrader C27H35N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-LFXHFR US20240425475, Compound GT-02389 3-[2-Methyl-4-oxo-5-[2-[2-(3-tricyclo[3.3.1.03,7]nonanylamino)ethoxy]ethylamino]quinazolin-3-yl]piperidine-2,6-dione\; BDBM708505; US20240425475, Compound GT-02389; 3-(5-((2-(2-(((3as,6as)- hexahydro-2,5- methanopentalen- 3a(1H)-yl)amino)ethoxy) ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione Cc1nc2cccc(NCCOCCNC34CC5CC(CC3C5)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C27H35N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-ZBPDT9 BDBM708511 3-[5-[4-(2-Adamantylamino)butylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25342322; SCHEMBL25342329; BDBM708511; US20240425475, Compound GT-02392; 3-(5-((4-(((1r,3r, 5r,7r)-adamantan-2- yl)amino)butyl) amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione Cc1nc2cccc(NCCCCNC3C4CC5CC(C4)CC3C5)c2c(=O)n1C1CCC(=O)NC1=O Degrader C28H37N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-G07JHJ BDBM708513 3-[5-[5-(2-Adamantylamino)pentylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346413; SCHEMBL25346420; BDBM708513; US20240425475, Compound GT-02393; 3-(5-((5-(((1r,3r, 5r,7r)-adamantan-2- yl)amino)pentyl) amino)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione Cc1nc2cccc(NCCCCCNC3C4CC5CC(C4)CC3C5)c2c(=O)n1C1CCC(=O)NC1=O Degrader C29H39N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-FR2HY8 SCHEMBL25345547 3-[2-Methyl-5-[2-[2-(4-methyl-1,4-diazepan-1-yl)ethoxy]ethylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25345547 Cc1nc2cccc(NCCOCCN3CCCN(C)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C24H34N6O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-DJKXMF US20240425475, Compound GT-02494 3-[2-Methyl-4-oxo-5-[6-(3-tricyclo[3.3.1.03,7]nonanylamino)hexylamino]quinazolin-3-yl]piperidine-2,6-dione\; BDBM708496; US20240425475, Compound GT-02494; 3-(5-((6-(((2R,3as,5S,6as)- hexahydro-2,5- methanopentalen-3a(1H)- yl)amino)hexyl)amino)-2- methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione Cc1nc2cccc(NCCCCCCNC34CC5CC(CC3C5)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C29H39N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-Y5MR4E US20240425475, Compound GT-02495 3-[2-Methyl-4-oxo-5-[7-(3-tricyclo[3.3.1.03,7]nonanylamino)heptylamino]quinazolin-3-yl]piperidine-2,6-dione\; BDBM708498; BDBM708517; US20240425475, Compound GT-02495; US20240425475, Compound GT-02497; 3-(5-((2-(2-(2-(((2R,3as,5S, 6as)-hexahydro-2,5- methanopentalen-3a(1H)- yl)amino)ethoxy)ethoxy) ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione; 3-(5-((7-(((3as, 6as)-hexahydro- 2,5-methanopentalen- 3a(1H)-yl)amino)heptyl) amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione Cc1nc2cccc(NCCCCCCCNC34CC5CC(CC3C5)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C30H41N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-JID038 US20240425475, Compound GT-02496 3-[2-Methyl-4-oxo-5-[5-(3-tricyclo[3.3.1.03,7]nonanylamino)pentylamino]quinazolin-3-yl]piperidine-2,6-dione\; BDBM708509; US20240425475, Compound GT-02496; 3-(5-((5-(((3as, 6as)-hexahydro- 2,5-methanopentalen- 3a(1H)-yl)amino)pentyl) amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione Cc1nc2cccc(NCCCCCNC34CC5CC(CC3C5)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C28H37N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-15TCDB WO2023151635-A1_GT-02497 . Cc1nc2cccc(NCCOCCOCCNC34CC5CC(CC3C5)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C29H39N5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-LPBP62 SCHEMBL25345100 3-[2-Methyl-5-[5-(4-methyl-1,4-diazepan-1-yl)pentylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25345100 Cc1nc2cccc(NCCCCCN3CCCN(C)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C25H36N6O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-WRC40R US20240425475, Compound GT-02502 3-[2-Methyl-5-[7-(4-methyl-1,4-diazepan-1-yl)heptylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346649; BDBM708500; US20240425475, Compound GT-02502; 3-(2-methyl-5- ((7-(4-methyl- 1,4-diazepan-1- yl)heptyl)amino)-4- oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione Cc1nc2cccc(NCCCCCCCN3CCCN(C)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C27H40N6O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-M8S85Y SCHEMBL25344412 3-[5-(5-Hydroxypent-1-ynyl)-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344412 Cc1nc2cccc(C#CCCCO)c2c(=O)n1C1CCC(=O)NC1=O Degrader C19H19N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-TKN4C1 US20240425475, Compound GT-02598 3-[5-(7-Hydroxyheptylamino)-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25342825; BDBM708502; US20240425475, Compound GT-02598; 3-(5-((7-hydroxyheptyl) amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione Cc1nc2cccc(NCCCCCCCO)c2c(=O)n1C1CCC(=O)NC1=O Degrader C21H28N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-51DZIE US20240425475, Compound GT-02601 3-[5-(1-Adamantylamino)-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; BDBM708504; US20240425475, Compound GT-02601; 3-(5-(((1s,3s)-adamantan- 1-yl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione Cc1nc2cccc(NC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C24H28N4O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-2FGTUH SCHEMBL29085676 3-[5-[2-(2-Hydroxyethoxy)ethylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL29085676 Cc1nc2cccc(NCCOCCO)c2c(=O)n1C1CCC(=O)NC1=O Degrader C18H22N4O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-FBBGQ7 SCHEMBL25344857 3-[2-Methyl-5-[2-[2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)ethoxy]ethylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344857 Cc1nc2cccc(NCCOCCN3CC4CC(C3)O4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C23H29N5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-438QMZ SCHEMBL29085660 3-[2-Methyl-5-[2-(2-morpholin-4-ylethoxy)ethylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL29085660 Cc1nc2cccc(NCCOCCN3CCOCC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C22H29N5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-ZAA85K SCHEMBL25342474 3-[2-Methyl-5-[2-[2-(4-morpholin-4-ylpiperidin-1-yl)ethoxy]ethylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25342474 Cc1nc2cccc(NCCOCCN3CCC(N4CCOCC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C27H38N6O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-0M5AKH SCHEMBL25344650 3-[2-Methyl-5-[2-[2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethoxy]ethylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344650 Cc1nc2cccc(NCCOCCN3CCC(N4CCN(C)CC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C28H41N7O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-PGAG4D SCHEMBL25344981 3-[2-Methyl-5-[2-[2-[4-(oxetan-3-yl)piperazin-1-yl]ethoxy]ethylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344981 Cc1nc2cccc(NCCOCCN3CCN(C4COC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C25H34N6O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-DE0J0O US20240425475, Compound GT-02621 3-[2-Methyl-5-[7-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)heptylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; BDBM708506; US20240425475, Compound GT-02621; 3-(5-((7-(6-oxa-3- azabicyclo[3.1.1 ]heptan-3- yl)heptyl)amino)-2- methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione Cc1nc2cccc(NCCCCCCCN3CC4CC(C3)O4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C26H35N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-XE45H1 US20240425475, Compound GT-02622 3-[2-Methyl-5-[7-(4-morpholin-4-ylpiperidin-1-yl)heptylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25345026; BDBM708508; US20240425475, Compound GT-02622; 3-(2-methyl-5-((7-(4- morpholinopiperidin-1- yl)heptyl)amino)-4- oxoquinazolin-3(4H)- yl)piperidine- 2,6-dione Cc1nc2cccc(NCCCCCCCN3CCC(N4CCOCC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C30H44N6O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-4HIUQU US20240425475, Compound GT-02623 3-[2-Methyl-5-[7-[4-(oxetan-3-yl)piperazin-1-yl]heptylamino]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25345840; BDBM708510; US20240425475, Compound GT-02623; 3-(2-methyl-5-((7-(4- (oxetan-3-yl)piperazin-1- yl)heptyl)amino)-4- oxoquinazolin-3(4H)- yl)piperidine- 2,6-dione Cc1nc2cccc(NCCCCCCCN3CCN(C4COC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C28H40N6O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-7OIN4S SCHEMBL25346815 3-[5-[5-(1-Adamantylamino)pent-1-ynyl]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346815 Cc1nc2cccc(C#CCCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C29H34N4O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-FX4JI8 SCHEMBL29085672 3-[2-Methyl-4-oxo-5-(5-piperidin-1-ylpent-1-ynyl)quinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL29085672 Cc1nc2cccc(C#CCCCN3CCCCC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C24H28N4O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-5VD1LO SCHEMBL25346447 3-[2-Methyl-5-[5-(4-methylpiperazin-1-yl)pent-1-ynyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346447 Cc1nc2cccc(C#CCCCN3CCN(C)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C24H29N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-E398TB SCHEMBL25437567 3-[2-Methyl-5-[5-[4-(oxetan-3-yl)piperazin-1-yl]pent-1-ynyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25437567 Cc1nc2cccc(C#CCCCN3CCN(C4COC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C26H31N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-O9Y2LT SCHEMBL25437995 3-[2-Methyl-5-[5-(4-methyl-1,4-diazepan-1-yl)pent-1-ynyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25437995 Cc1nc2cccc(C#CCCCN3CCCN(C)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C25H31N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-TMI2K8 SCHEMBL25346370 3-[5-(8-Hydroxyoct-1-ynyl)-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346370 Cc1nc2cccc(C#CCCCCCCO)c2c(=O)n1C1CCC(=O)NC1=O Degrader C22H25N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-QERW6Z SCHEMBL25346021 3-[5-[8-(1-Adamantylamino)oct-1-ynyl]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346021 Cc1nc2cccc(C#CCCCCCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C32H40N4O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-L8V1B3 SCHEMBL25436855 3-[2-Methyl-5-[8-[4-(oxetan-3-yl)piperazin-1-yl]oct-1-ynyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25436855 Cc1nc2cccc(C#CCCCCCCN3CCN(C4COC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C29H37N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-BGFGUU SCHEMBL25345259 3-[5-(5-Hydroxypentyl)-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25345259 Cc1nc2cccc(CCCCCO)c2c(=O)n1C1CCC(=O)NC1=O Degrader C19H23N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-RRQHFN US20240425475, Compound GT-02645 3-[2-Methyl-5-[8-(4-methylpiperazin-1-yl)oct-1-ynyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344738; BDBM708491; US20240425475, Compound GT-02645; 3-(2-methyl-5-(8-(4- methylpiperazin-1- yl)oct-1-yn-1-yl)- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione Cc1nc2cccc(C#CCCCCCCN3CCN(C)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C27H35N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-L23E9S SCHEMBL25344972 3-[2-Methyl-5-[8-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]oct-1-ynyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344972 Cc1nc2cccc(C#CCCCCCCN3CCC(N4CCN(C)CC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C32H44N6O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-YL2FWD SCHEMBL25343911 3-[2-Methyl-5-[8-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)oct-1-ynyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25343911 Cc1nc2cccc(C#CCCCCCCN3CC4CC(C3)O4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C27H32N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-WVCPRI SCHEMBL25345463 3-[5-(7-Hydroxyheptoxy)-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25345463 Cc1nc2cccc(OCCCCCCCO)c2c(=O)n1C1CCC(=O)NC1=O Degrader C21H27N3O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-MLFNOI US20240425475, Compound GT-02759 3-[5-[5-(1-Adamantylamino)pentyl]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346005; BDBM708495; US20240425475, Compound GT-02759; 3-(5-(5-(((3s,5s,7s)- adamantan-1- yl)amino)pentyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione Cc1nc2cccc(CCCCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C29H38N4O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-01FLLG SCHEMBL25344586 3-[5-(8-Hydroxyoctyl)-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344586 Cc1nc2cccc(CCCCCCCCO)c2c(=O)n1C1CCC(=O)NC1=O Degrader C22H29N3O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-OTXC98 SCHEMBL25344057 3-[2-Methyl-5-[5-[4-(oxetan-3-yl)piperazin-1-yl]pentyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25344057 Cc1nc2cccc(CCCCCN3CCN(C4COC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C26H35N5O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-4BK7CC WO2023151635-A1_GT-02762 3-[2-Methyl-5-[5-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)pentyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione Cc1nc2cccc(CCCCCN3CC4CC(C3)O4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C24H30N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-G5NBH4 SCHEMBL29085657 3-[2-Methyl-5-[5-(4-methylpiperazin-1-yl)pentyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL29085657 Cc1nc2cccc(CCCCCN3CCN(C)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C24H33N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-KOUJVP SCHEMBL25346430 3-[2-Methyl-5-[5-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pentyl]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346430 Cc1nc2cccc(CCCCCN3CCC(N4CCN(C)CC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C29H42N6O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-Q2N9NM WO2023151635-A1_GT-02767 . Cc1nc2cccc(NCCCCCCCN[C@@]34CC5C[C@@](C)(C[C@@](C)(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C33H47N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-ATN7U8 US20240425475, Compound GT-02768 3-[5-[7-[1-(1-Adamantyl)ethylamino]heptylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25438646; BDBM708514; US20240425475, Compound GT-02768; 3-(5-((7-((1-((3r,5r,7r)- adamantan-1- yl)ethyl)amino)heptyl) amino)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione Cc1nc2cccc(NCCCCCCCNC(C)C34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C33H47N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-IM0KJS SCHEMBL25342774 3-[5-[7-(1-Adamantylamino)heptoxy]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25342774 Cc1nc2cccc(OCCCCCCCNC34CC5CC(CC(C5)C3)C4)c2c(=O)n1C1CCC(=O)NC1=O Degrader C31H42N4O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-8VFYJN SCHEMBL25346163 3-[2-Methyl-5-[7-[4-(oxetan-3-yl)piperazin-1-yl]heptoxy]-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25346163 Cc1nc2cccc(OCCCCCCCN3CCN(C4COC4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C28H39N5O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-GKTUWA WO2023193760-A1_GS-640 . O=C1CCC(N2C(=O)c3ccc(OC[C@H]4C[C@H](n5cc(-c6cnc7ccccc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C32H28N6O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-T5SQCV WO2023193760-A1_GS-641 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ncccc6OC6CC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C32H32N6O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-4RSTUN WO2023193760-A1_GS-642 . O=C1CCC(N2C(=O)c3ccc(NCCCn4cc(-c5cnc6ccccc6n5)c(C5CC5)n4)cc3C2=O)C(=O)N1 Degrader C30H27N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-31G2CR WO2023193760-A1_GS-643 . Cc1nc(-c2cn([C@H]3C[C@@H]3CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)nc2C2CC2)ccc1F Degrader C29H27FN6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-3HY3RS WO2023193760-A1_GS-644 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6cnc7ccc(N8CC(O)C8)cc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C35H34N8O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-L71FY2 WO2023193760-A1_GS-645 . Cc1nc(-c2cn(CC3CC3CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)nc2C2CC2)ccc1F Degrader C30H29FN6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-FMQYKH WO2023193760-A1_GS-646 . COC1CCCCC1c1cn([C@H]2C[C@H](CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)nc1C1CC1 Degrader C31H37N5O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-ERYDAS WO2023193760-A1_GS-647 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6cccc(N7CC(O)C7)n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C32H33N7O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-OKJ3HM WO2023193760-A1_GS-648 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5nc(C6CC6)c6nccnc65)C4)cc3C2=O)C(=O)N1 Degrader C26H25N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-5DX6YE WO2023193760-A1_GS-649 . Cn1ncc2ccnc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)c21 Degrader C31H30N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-ST8R51 WO2023193760-A1_GS-650 . CN(C)c1ccccc1-c1cn([C@H]2C[C@H](CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)nc1C1CC1 Degrader C32H34N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-SM98S5 WO2023193760-A1_GS-651 . O=C1CCC(N2Cc3cc(NC[C@H]4C[C@H](n5cc(-c6cnc7ccccc7n6)c(C6CC6)n5)C4)ccc3C2=O)C(=O)N1 Degrader C32H31N7O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-L1HHGZ WO2023193760-A1_GS-652 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ccccc6N6CCNCC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C34H37N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-80IQYW WO2023193760-A1_GS-653 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6cccc(N7CCC7)c6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C33H34N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-O9M9DG WO2023193760-A1_GS-654 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ccccc6C6CCNCC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C35H38N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-G7FYC8 WO2023193760-A1_GS-655 . CN1CC(c2ccc3ncc(-c4cn([C@H]5C[C@H](CNc6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)C5)nc4C4CC4)nc3c2)C1 Degrader C36H36N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-CP8MPC WO2023193760-A1_GS-656 . CC(C)n1ncc2cnc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C(F)F)cc21 Degrader C31H30F2N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-9OOJ9Y WO2023193760-A1_GS-657 . Cn1ncc2cnc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C(F)F)cc21 Degrader C29H26F2N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-NVA4W1 WO2023193760-A1_GS-658 . Cn1cnc2cnc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)cc21 Degrader C31H30N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-LPZMVP WO2023193760-A1_GS-659 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6cnc7ccc(N8CCC(O)C8)cc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C36H36N8O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-MFGJKR WO2023193760-A1_GS-660 . CC(C)n1cc2ccnc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)c2n1 Degrader C33H34N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-R0CNVU WO2023193760-A1_GS-661 . CC(C)n1ncc2ccnc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)c21 Degrader C33H34N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-C13441 WO2023193760-A1_GS-662 . O=C1CCC(N2Cc3ccc(NC[C@H]4C[C@H](n5cc(-c6cnc7ccccc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C32H31N7O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-3TU1DS WO2023193760-A1_GS-663 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5nc(C6CC6)c6cncnc65)C4)cc3C2=O)C(=O)N1 Degrader C26H25N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-DSKQ27 WO2023193760-A1_GS-664 . CC(C)n1cnc2cnc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)cc21 Degrader C33H34N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-8FYERZ WO2023193760-A1_GS-665 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ncccc6C6CCNCC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C34H37N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-ZK9QDG WO2023193760-A1_GS-666 . CN1CCC(Nc2cn([C@H]3C[C@H](CNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)CC1 Degrader C30H37N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-HIHATZ WO2023193760-A1_GS-667 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(NC6CCCCC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C30H36N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-1VEG8D WO2023193760-A1_GS-668 . Cc1cc(F)cnc1-c1cn([C@H]2C[C@H](CNc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)nc1C(F)F Degrader C28H27F3N6O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-T4TUNA WO2023193760-A1_GS-669 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(Nc6ccccn6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C29H29N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-PJR1TF WO2023193760-A1_GS-670 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(Nc6cccnc6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C29H29N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-M6EZQA WO2023193760-A1_GS-671 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(Nc6ccncc6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C29H29N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-Z9BWZG WO2023193760-A1_GS-672 . Cc1ccc2c(C3CC3)nn([C@H]3C[C@H](CNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)c2n1 Degrader C28H28N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-UNVRD0 WO2023193760-A1_GS-673 . Cc1cnc2c(c1)c(C1CC1)nn2[C@H]1C[C@H](CNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C1 Degrader C28H28N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-1TF9CY WO2023193760-A1_GS-674 . COc1ccc2c(C3CC3)nn([C@H]3C[C@H](CNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)c2n1 Degrader C28H28N6O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-S35TUN WO2023193760-A1_GS-675 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6cc7c(cn6)cnn7C6CNC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C33H33N9O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-RQFBGE WO2023193760-A1_GS-676 . Cc1cc(F)cnc1-c1cn([C@H]2C[C@H](CNc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)nc1C1CC1 Degrader C30H31FN6O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-DAO2ZX WO2023193760-A1_GS-677 . Cc1nc(-c2cn([C@H]3C[C@H](CNc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)nc2C(F)F)ccc1F Degrader C28H27F3N6O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-RV2LKS WO2023193760-A1_GS-678 . Cn1ncc2cnc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)cc21 Degrader C31H32N8O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-9MJEBD WO2023193760-A1_GS-679 . Cc1ccnc2c1c(C1CC1)nn2[C@H]1C[C@H](CNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C1 Degrader C28H28N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-5C2SIK WO2023193760-A1_GS-680 . CN1CC(n2cc3cnc(-c4cn([C@H]5C[C@H](CNc6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)C5)nc4C4CC4)cc3n2)C1 Degrader C34H35N9O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-0OB1I4 WO2023193760-A1_GS-681 . COc1ccnc2c1c(C1CC1)nn2[C@H]1C[C@H](CNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C1 Degrader C28H28N6O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-JYBU0U WO2023193760-A1_GS-682 . COc1cnc2c(c1)c(C1CC1)nn2[C@H]1C[C@H](CNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C1 Degrader C28H28N6O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-AA160M WO2023193760-A1_GS-683 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ncc(F)cc6N6CCNCC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C33H35FN8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-SI5XM4 WO2023193760-A1_GS-684 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ccc7[nH]ncc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C30H28N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-NFLBEC WO2023193760-A1_GS-685 . O=C1CCC(N2C(=O)c3ccc(NCCC[C@H]4C[C@H](n5cc(-c6nccc7c6NCCC7)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C34H37N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-AYM85G WO2023193760-A1_GS-686 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ncc(F)cc6C6CCNCC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)C1 Degrader C35H37FN6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-7NXWDO WO2023193760-A1_GS-687 . Cn1ccnc1-c1cn([C@H]2C[C@H](CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)nc1C1CC1 Degrader C28H29N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-LD3QOP WO2023193760-A1_GS-688 . Cc1c2ccccc2nn1[C@H]1C[C@H](CNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C1 Degrader C26H25N5O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-UM760P WO2023193760-A1_GS-689 . Cc1nn([C@H]2C[C@H](CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c2ccccc12 Degrader C26H25N5O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-DFF77Q WO2023193760-A1_GS-690 . Cn1nccc1-c1cn([C@H]2C[C@H](CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)nc1C1CC1 Degrader C28H29N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-8NVLOJ WO2023193760-A1_GS-691 . Cn1cncc1-c1cn([C@H]2C[C@H](CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)nc1C1CC1 Degrader C28H29N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-UZ1LS4 WO2023193760-A1_GS-693 . Cc1cccc2cnn([C@H]3C[C@H](CNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)c12 Degrader C26H25N5O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-0JHHXT WO2023193760-A1_GS-694 . Cc1cccc2cn([C@H]3C[C@H](CNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)nc12 Degrader C26H25N5O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-X887T6 WO2023193760-A1_GS-695 . Cn1ccc2nc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)ccc21 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-JV1IM8 WO2023193760-A1_GS-696 . CC(C)n1ccc2nc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)ccc21 Degrader C34H35N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-ZWVDE0 WO2023193760-A1_GS-697 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ncc(F)c7cccnc67)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C32H28FN7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-Q8T0BG WO2023193760-A1_GS-699 . Cn1ncc2nc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)ccc21 Degrader C31H30N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-68K3OE WO2023193760-A1_GS-700 . CC(C)n1ncc2nc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)ccc21 Degrader C33H34N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-QKBY6C WO2023193760-A1_GS-701 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(C6CCC(O)CC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C30H35N5O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-TB597B WO2023193760-A1_GS-702 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6cnc7c(NCC(O)CO)cccc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C35H36N8O6 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-9OH9EW WO2023193760-A1_GS-703 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(C6CCCC(O)C6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C30H35N5O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-FD034M WO2023193760-A1_GS-704 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6cc7c(cn6)cnn7CC(F)(F)F)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C32H29F3N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-A41QE7 WO2023193760-A1_GS-705 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ccc7c(n6)CCC7O)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C32H32N6O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-SZ8HMJ WO2023193760-A1_GS-706 . NC1CCN(c2ccc3ncc(-c4cn([C@H]5C[C@H](CNC6=CC7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7C=C6)C5)nc4C4CC4)nc3c2)C1 Degrader C36H39N9O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-4CXI0B WO2023193760-A1_GS-707 . CN(C)c1nc(-c2cn([C@H]3C[C@H](CNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)ccc1F Degrader C31H32FN7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-Q1MVTR WO2023193760-A1_GS-708 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(NC6CCOCC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C29H34N6O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-XXLZ1K WO2023193760-A1_GS-709 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(NC6CCC(O)CC6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C30H36N6O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-TAR0FA WO2023193760-A1_GS-710 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6cnc7c(NC(CO)CO)cccc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C35H36N8O6 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-EELFRK WO2023193760-A1_GS-711 . Cc1nc(-c2cn(C[C@H]3C[C@H](Nc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)ccc1F Degrader C30H29FN6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-21W490 WO2023193760-A1_GS-712 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6cnc7cc(N8CC(O)C8)ccc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C35H34N8O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-SSJ5RF WO2023193760-A1_GS-713 . Cc1cccc(-c2nn([C@H]3C[C@H](CNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)cc2C2CC2)n1 Degrader C30H30N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-42KVOQ WO2023193760-A1_GS-714 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ccc7cn[nH]c7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C30H28N8O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-NAL1JV WO2023193760-A1_GS-715 . Cc1nc(-c2cn([C@H]3C[C@H](COc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)ccc1F Degrader C30H28FN5O5 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-POZB1J WO2023193760-A1_GS-716 . Cc1nc(-c2cn([C@H]3C[C@H](CNc4cc5c(cc4F)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)ccc1F Degrader C30H28F2N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-CIB77K WO2023193760-A1_GS-717 . Cc1cc(F)cnc1-c1cn([C@H]2C[C@H](CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)nc1C1CC1 Degrader C30H29FN6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-EBBQWJ WO2023193760-A1_GS-718 . O=C1CCC(N2C(=O)c3cc(F)c(NCCC[C@H]4C[C@H](n5cc(-c6cnc7ccccc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C34H32FN7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-ARJRFT WO2023193760-A1_GS-719 . Cc1cc(F)cnc1-c1cn([C@H]2C[C@H](CNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)nc1C(F)F Degrader C28H25F3N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-5Y8MX9 WO2023193760-A1_GS-720 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ccc7[nH]ccc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-D5I8NM WO2023193760-A1_GS-721 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-c6ccc7cc[nH]c7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-2M5ERT WO2023193760-A1_GS-722 . Cn1ccc2ccc(-c3cn([C@H]4C[C@H](CNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)nc3C3CC3)nc21 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-CDE52I WO2023193760-A1_GS-723 . Cc1nc(-c2cn(C3CC(F)(CNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)ccc1F Degrader C30H28F2N6O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-NH0CAA WO2023193760-A1_GS-724 . O=C1CCC(N2C(=O)c3ccc(NCCC4CC5(C4)CC(n4cc(-c6cnc7ccccc7n6)c(C6CC6)n4)C5)cc3C2=O)C(=O)N1 Degrader C36H35N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-NZG9G2 WO2023193760-A1_GS-725 . O=C1CCC(N2Cc3ccc(CC[C@H]4C[C@H](n5cc(-c6cnc7ccccc7n6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C33H32N6O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-DA1R1N WO2023193760-A1_GS-726 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc(-n6cccn6)c(C6CC6)n5)C4)cc3C2=O)C(=O)N1 Degrader C27H27N7O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-A0PVDD WO2023193760-A1_GS-727 . O=C1CCC(N2C(=O)c3ccc(NC[C@H]4C[C@H](n5cc6ccccc6n5)C4)cc3C2=O)C(=O)N1 Degrader C25H23N5O4 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-6CNM9W SCHEMBL25767588 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-3H-isoindole-5-carbonitrile; SCHEMBL31305201 N#CC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C14H10FN3O3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-IAVN2T SCHEMBL26087823 4-chloro-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carbonitrile N#CC1=C(\Cl)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C14H10ClN3O3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-UWAMM4 WO2023207241A1_100 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C4=CC=C(C(=O)C5=CC=CC=C5)C=C4)=C/3F)C2=O)C(=O)N1 Degrader C28H22FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-HBSZ2W WO2023207241A1_101 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C4=CC=C(OC5=CC=CC=C5)C=C4)=C/3F)C2=O)C(=O)N1 Degrader C27H22FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-EOP5ZD WO2023207241A1_102 . COC1=CC=C(C(=O)NCC2=C(F)C3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1OC Degrader C23H22FN3O6 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-U7L64B WO2023207241A1_103 . CC(C)(C)OC1=CC=C(C(=O)NCC2=C(F)C3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C25H26FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-SNLRYH WO2023207241A1_104 . COC1=CC(C)=CC=C1C(=O)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C23H22FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-77SLEG WO2023207241A1_105 . CSC1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C(C)=C1 Degrader C23H22FN3O4S GSPT1 P15170 CRBN WO-2023207241-A1 TPD-C8X901 WO2023207241A1_106 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C4=C/C=C5/CCC(=O)/C5=C\4)=C/3F)C2=O)C(=O)N1 Degrader C24H20FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-E5QQTK WO2023207241A1_107 . CS(=O)(=O)C1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C22H20FN3O6S GSPT1 P15170 CRBN WO-2023207241-A1 TPD-YIMLNA WO2023207241A1_108 . O=C1CCC(N2CC3=C(C=CC(CNC(=O)C4=CC=C(CO)C=C4)=C3F)C2=O)C(=O)N1 Degrader C22H20FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-2MPCJ2 WO2023207241A1_109 . CC1=CC=C(C(=O)NCC2=C(F)C3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)C(O)=C1 Degrader C22H20FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-5DY5HM WO2023207241A1_11 . CC(C)(C)OC(=O)NCC1=C(\Cl)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C19H22ClN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-HMU1A7 WO2023207241A1_110 . O=C1CCC(N2CC3=C(C=CC(CNC(=O)C4=CC=C(N5CCCC5)C=C4)=C3F)C2=O)C(=O)N1 Degrader C25H25FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-O1I4HX WO2023207241A1_111 . CC1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C(N)=C1 Degrader C22H21FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-JVALT8 WO2023207241A1_112 . CC1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1N Degrader C22H21FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-ZE14VS WO2023207241A1_113 . NC1=CC(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)=CC=C1Cl Degrader C21H18ClFN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-GMZLPB WO2023207241A1_114 . CS(=O)(=O)C1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C(N)=C1 Degrader C22H21FN4O6S GSPT1 P15170 CRBN WO-2023207241-A1 TPD-SCDWR6 WO2023207241A1_115 . NS(=O)(=O)C1=CC(C(=O)NCC2=C(F)C3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)=CC=C1Cl Degrader C21H18ClFN4O6S GSPT1 P15170 CRBN WO-2023207241-A1 TPD-BE1013 WO2023207241A1_116 . O=C1CCC(N2CC3=C(C=CC(CNC(=O)C4=CC=C(Cl)C(F)=C4)=C3F)C2=O)C(=O)N1 Degrader C21H16ClF2N3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-TSRFVY WO2023207241A1_117 . O=C1CCC(N2CC3=C(C=CC(CNC(=O)C4=CC=C(Cl)C=C4F)=C3F)C2=O)C(=O)N1 Degrader C21H16ClF2N3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-7P7BXA WO2023207241A1_118 . O=C1CCC(N2CC3=C(C=CC(CNC(=O)C4=CC=C(Cl)C(F)=C4)=C3Cl)C2=O)C(=O)N1 Degrader C21H16Cl2FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-Z3RZS2 WO2023207241A1_119 . O=C1CCC(N2CC3=C(C=CC(CNC(=O)C4=CC=C(Cl)C=C4F)=C3Cl)C2=O)C(=O)N1 Degrader C21H16Cl2FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-FTWXEM WO2023207241A1_12 . NCC1=C(\Cl)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C14H14ClN3O3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-4D55HT WO2023207241A1_120 . CC1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1F Degrader C22H19F2N3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-P96VFV WO2023207241A1_121 . CC1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C(F)=C1 Degrader C22H19F2N3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-7Y0LF1 WO2023207241A1_122 . CC1=CC=C(C(=O)NCC2=C(\Cl)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1F Degrader C22H19ClFN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-1RNLVY WO2023207241A1_123 . CC1=CC=C(C(=O)NCC2=C(\Cl)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C(F)=C1 Degrader C22H19ClFN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-DBZUKE WO2023207241A1_124 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C(F)(F)C4=CC=C(Cl)C=C4)=C/3F)C2=O)C(=O)N1 Degrader C22H17ClF3N3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-449017 WO2023207241A1_125 . CCN1C(=O)CCC(N2CC3=C(C=CC(CNC(=O)C4C=CC(Cl)=CC4)=C3F)C2=O)C1=O Degrader C23H23ClFN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-OKP1IR WO2023207241A1_126 . CCOC(=O)CN1C(=O)CCC(N2CC3=C(C=CC(CNC(=O)C4C=CC(Cl)=CC4)=C3F)C2=O)C1=O Degrader C25H25ClFN3O6 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-U8NMOJ WO2023207241A1_127 . CC(C)OC(=O)N1C(=O)CCC(N2CC3=C(C=CC(CNC(=O)C4=CC=C(Cl)C=C4)=C3F)C2=O)C1=O Degrader C25H23ClFN3O6 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-DJCWF1 WO2023207241A1_128 . CC(C)OC(=O)OCN1C(=O)CCC(N2CC3=C(C=CC(CNC(=O)C4=CC=C(Cl)C=C4)=C3F)C2=O)C1=O Degrader C26H25ClFN3O7 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-ONY97C WO2023207241A1_129 . CC(C)(C)C(=O)OCN1C(=O)CCC(N2CC3=C(C=CC(CNC(=O)C4=CC=C(Cl)C=C4)=C3F)C2=O)C1=O Degrader C27H27ClFN3O6 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-WVDN6X SCHEMBL25012193 6-chloro-2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-5-carbonitrile; SCHEMBL30270871 N#CC1=CC2=C(C=C1Cl)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C14H10ClN3O3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-NFJ7MR WO2023207241A1_130 . CC1=CC=C(C(=O)NCC2=C(F)C3=C(C=C2)C(=O)N(C2CCC(=O)N(COC(=O)OC(C)C)C2=O)C3)C(F)=C1 Degrader C27H27F2N3O7 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-Y2X1Q9 WO2023207241A1_131 . O=C(CC1=CC=C(Cl)C=C1Cl)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C22H18Cl2FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-SCD8OP WO2023207241A1_132 . CCCCOC1=CC=C(CC(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C26H28FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-KLHO95 WO2023207241A1_133 . O=C(CC1=CC(C2=CC=CC=C2)=CC=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C28H24FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-4U6JUA WO2023207241A1_134 . O=C(C/C1=C/NC2=C1C=C(F)C=C2)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H20F2N4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-VLQKLO WO2023207241A1_135 . O=C(C/C1=C/NC2=C1C(Br)=CC=C2)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H20BrFN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-BN0A9L WO2023207241A1_136 . O=C(C/C1=C/C2=C(C=CC=C2)S1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H20FN3O4S GSPT1 P15170 CRBN WO-2023207241-A1 TPD-K3T3M7 WO2023207241A1_137 . O=C(CCC1=CC=CC(F)=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C23H21F2N3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-6QFTUW WO2023207241A1_138 . O=C(CC/C1=C/C=C\C2=C1C=CC=C2)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C27H24FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-AO8MQZ WO2023207241A1_139 . O=C(CCCC1=CC=C(I)C=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H23FIN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-TOF79O WO2023207241A1_14 . CC(C)(C)OC(=O)NCC1=C/C2=C(\C=C/1Cl)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C19H22ClN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-1S1Q4Q WO2023207241A1_140 . O=C(CCC/C1=C/C=C2/C/C=C3/C=CCC4=CC=C1C2C43)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C34H32FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-UPO929 WO2023207241A1_141 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C4(C5=CC=C(Br)C=C5F)CC4)=C/3F)C2=O)C(=O)N1 Degrader C24H20BrF2N3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-A2PA8N WO2023207241A1_142 . O=C(/C=C/C1=CC=C(Cl)C=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C23H19ClFN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-EZNB3E WO2023207241A1_143 . CCCOC1=CC=C(/C=C/C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C26H26FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-Z91JST WO2023207241A1_144 . O=C(C#CC1=CC=CC=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C23H18FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-6Y281P WO2023207241A1_145 . O=C(C#CC1=CC=C(Cl)C=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C23H17ClFN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-NIVFSG WO2023207241A1_146 . O=C(C#CC1=CC=CC(O)=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C23H18FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-SIYMQK WO2023207241A1_147 . O=C(C#CC1=CC=C(C2=CC=CC=C2)C=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C29H22FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-8Z70QF WO2023207241A1_148 . O=C(C#CC1=CC=CC=N1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C22H17FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-XUA44A WO2023207241A1_149 . N#CC1=CC=C(NCC(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C23H20FN5O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-J9AELZ WO2023207241A1_15 . NCC1=CC2=C(C=C1Cl)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C14H14ClN3O3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-KIRYVB WO2023207241A1_150 . O=C(CNC(=O)C1=CC=C(Cl)C=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C23H20ClFN4O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-3FNTIR WO2023207241A1_151 . CCCCCCCC(=O)NCC(=O)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H31FN4O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-OIXV5K WO2023207241A1_152 . O=C(COC1=C(Cl)C=C(Cl)C=C1Cl)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C22H17Cl3FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-S830D4 WO2023207241A1_153 . O=C(CO/C1=N/N(CC2=CC=CC=C2)C2=C1C=CC=C2)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C30H26FN5O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-8G269C WO2023207241A1_154 . O=C(CCOC1=CC=CC=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C23H22FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-R9Z70L WO2023207241A1_155 . O=C(CSC1=CC=NC=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C21H19FN4O4S GSPT1 P15170 CRBN WO-2023207241-A1 TPD-D7CR5P WO2023207241A1_156 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C4CC5(CCC5)C4)=C/3F)C2=O)C(=O)N1 Degrader C22H24FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-DYZDBD WO2023207241A1_157 . CCCCCCCCCCC(=O)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C25H34FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-XOZYRZ WO2023207241A1_158 . CN(C)CCCCC(=O)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C21H27FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-M1PTM4 WO2023207241A1_159 . O=C(CCCCN1CCCCC1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C24H31FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-U1VHZE SCHEMBL25012220 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-3H-isoindole-4-carbonitrile N#C/C1=C/C(F)=C\C2=C1CN(C1CCC(=O)NC1=O)C2=O Degrader C14H10FN3O3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-G47O2H WO2023207241A1_160 . O=C(CCP(C1=CC=CC=C1)C1=CC=CC=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C29H27FN3O4P GSPT1 P15170 CRBN WO-2023207241-A1 TPD-IG4MQY WO2023207241A1_161 . O=C(CCSC(=S)SCC1=CC=CC=C1)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C25H24FN3O4S3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-5X5SLO WO2023207241A1_162 . COC1C=C(C)C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)=C(C)C1C Degrader C35H40FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-INQZAG WO2023207241A1_163 . CCCCCCCCCCCCSC(=S)SC(C)(C)C(=O)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C31H44FN3O4S3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-CJMHX3 WO2023207241A1_164 . CCCCCCCCCCCCSC(=S)SC(C)(C#N)CCC(=O)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C33H45FN4O4S3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-VDJ2D1 WO2023207241A1_165 . O=C1CCC(N2CC3=C(/C=C\C(CNC/C4=C/C5=C(C=CC(Cl)=C5)O4)=C/3F)C2=O)C(=O)N1 Degrader C23H19ClFN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-IE0GLU WO2023207241A1_166 . O=C1CCC(N2CC3=C(/C=C\C(CNCC4=CC=C(OC5=CC=CC=C5)C=C4)=C/3F)C2=O)C(=O)N1 Degrader C27H24FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-YSLX8X WO2023207241A1_167 . CCCC1=CC=C(CNCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C24H26FN3O3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-2WL3VF WO2023207241A1_168 . O=C1CCC(N2CC3=C(/C=C\C(CNCC4=CC=C(Cl)C=C4)=C/3F)C2=O)C(=O)N1 Degrader C21H19ClFN3O3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-9EBM3C WO2023207241A1_169 . O=C(C/C1=C/C2=C(C=CC=C2)S1)NC/C1=C/C(F)=C\C2=C1CN(C1CCC(=O)NC1=O)C2=O Degrader C24H20FN3O4S GSPT1 P15170 CRBN WO-2023207241-A1 TPD-EILI11 SCHEMBL25280630 3-[4-(Aminomethyl)-6-fluoro-1-oxo-isoindolin-2-yl]piperidine-2,6-dione; 3-[4-(aminomethyl)-6-fluoro-1-oxo-isoindolin-2-yl]piperidine-2,6-dione; 2813335-37-2 NC/C1=C/C(F)=C\C2=C1CN(C1CCC(=O)NC1=O)C2=O Degrader C14H14FN3O3 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-KDK0LU WO2023207241A1_170 . O=C(CCC1=C2\C=CC=C\C2=C\C=C\1)NC/C1=C/C(F)=C\C2=C1CN(C1CCC(=O)NC1=O)C2=O Degrader C27H24FN3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-TM91GK WO2023207241A1_171 . O=C1CCC(N2CC3=C(/C=C(F)\C=C/3CNC(=O)C(F)(F)C3=CC=C(Cl)C=C3)C2=O)C(=O)N1 Degrader C22H17ClF3N3O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-WUADLH WO2023207241A1_172 . CC(C)(C)C1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C(N)=C1 Degrader C25H27FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-09MIDA WO2023207241A1_173 . CC(C)(C)C1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1O Degrader C25H26FN3O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-2XTMJH WO2023207241A1_174 . CC(C)(CN)C1=CC=C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C25H27FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-8OFBK7 WO2023207241A1_175 . NCC1=CC=C(C2=CC=C(C(=O)NCC3=C(\F)C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)C=C2)C=C1 Degrader C28H25FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-FDMKY8 WO2023207241A1_176 . NC1=CC(C2=CC=CC=C2)=CC=C1C(=O)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2 Degrader C27H23FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-VG303R WO2023207241A1_177 . NC1=CC=C(C2=CC=C(C(=O)NCC3=C(\F)C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)C=C2)C=C1 Degrader C27H23FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-750P9H WO2023207241A1_178 . COC1=C(OCC2=CC=CC=C2)C=C(N)C(C(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)=C1 Degrader C29H27FN4O6 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-AIZNF1 WO2023207241A1_179 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C4=CC(O)=C(OCC5=CC=CC=C5)C=C4)=C/3F)C2=O)C(=O)N1 Degrader C28H24FN3O6 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-5M0C8U WO2023207241A1_180 . CC(CCC(=O)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2)(C1=CC=C(O)C=C1)C1=CC=C(O)C=C1 Degrader C31H30FN3O6 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-5EKPHP WO2023207241A1_181 . N[C@@H](CC(=O)NCC1=C(\F)C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2)C(C1=CC=CC=C1)C1=CC=CC=C1 Degrader C30H29FN4O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-0DMWO5 WO2023207241A1_182 . NCCC1=C(Cl)C=C(NC(=O)NCC2=C(\F)C3=C(\C=C/2)C(=O)N(C2CCC(=O)NC2=O)C3)C=C1 Degrader C23H23ClFN5O4 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-021VZ6 WO2023207241A1_183 . O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)NC4=CC(Cl)=C(CCO)C=C4)=C/3F)C2=O)C(=O)N1 Degrader C23H22ClFN4O5 GSPT1 P15170 CRBN WO-2023207241-A1 TPD-BYII1J WO2024041661-A1_UB-001 . CCn1cnc2c(NCc3ccc(-c4cccc(CO)n4)cc3)nc(N3CCOCC3)nc21 Degrader C24H27N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-OQG9UV WO2024041661-A1_UB-002 . CCn1cnc2c(NCc3ccc(-c4cccc(CO)n4)cc3)nc(N3CCNCC3)nc21 Degrader C24H28N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-6B7IKY WO2024041661-A1_UB-003 . CCn1cnc2c(NCc3ccc(-c4cccc(CO)n4)cc3)nc(N3CCN(C)CC3)nc21 Degrader C25H30N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-TEONLH WO2024041661-A1_UB-004 . CCn1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCNCC3)nc21 Degrader C24H27N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-L4MWOF WO2024041661-A1_UB-005 . CCn1cnc2c(NCc3ccc(-c4cccc(CO)c4)cc3)nc(N3CCNCC3)nc21 Degrader C25H29N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-HQPUMB WO2024041661-A1_UB-006 . CCn1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(NN3CCC(O)CC3)nc21 Degrader C25H29N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-KH3KK9 WO2024041661-A1_UB-008 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCCCC3)nc21 Degrader C26H30N6 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-ITHY1L WO2024041661-A1_UB-009 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCOCC3)nc21 Degrader C25H28N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-HMXGNS WO2024041661-A1_UB-010 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCNCC3)nc21 Degrader C25H29N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-8IRMUT WO2024041661-A1_UB-011 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCN(C)CC3)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-CL8SEE WO2024041661-A1_UB-012 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCC[C@H](N)C3)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-GMYM1J WO2024041661-A1_UB-013 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCC[C@@H](N)C3)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-YQ9CB6 WO2024041661-A1_UB-014 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N[C@@H]3CCCNC3)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-8DQC6N WO2024041661-A1_UB-015 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N[C@H]3CCCNC3)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-FP7RVG WO2024041661-A1_UB-016 6-N-[(4-phenylphenyl)methyl]-2-N-piperidin-4-yl-9-propan-2-ylpurine-2,6-diamine CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(NC3CCNCC3)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-H0POCF WO2024041661-A1_UB-017 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCC(N)CC3)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-RVRDM1 WO-2024041661-A1_UB-018 2-N-(4-aminocyclohexyl)-6-N-[(4-phenylphenyl)methyl]-9-propan-2-ylpurine-2,6-diamine\; CHEMBL575450; BDBM50378212 CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc21 Degrader C27H33N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-DBEPRP WO-2024041661-A1_UB-019 2-N-(4-aminocyclohexyl)-6-N-[(4-phenylphenyl)methyl]-9-propan-2-ylpurine-2,6-diamine\; CHEMBL575450; BDBM50378212 CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N[C@H]3CC[C@@H](N)CC3)nc21 Degrader C27H33N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-SVX23A SCHEMBL27144015 2-[(2R)-2-methylpiperazin-1-yl]-N-[(4-phenylphenyl)methyl]-9-propan-2-ylpurin-6-amine\; SCHEMBL27144015 CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCNC[C@H]3C)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-DZIES3 SCHEMBL27140401 2-[(2S)-2-methylpiperazin-1-yl]-N-[(4-phenylphenyl)methyl]-9-propan-2-ylpurin-6-amine\; SCHEMBL27140401 CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCNC[C@@H]3C)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-F9TI52 WO2024041661-A1_UB-022 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCNC[C@H]3CO)nc21 Degrader C26H31N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-OQZPE7 SCHEMBL29164862 [(2R)-1-[6-[(4-phenylphenyl)methylamino]-9-propan-2-ylpurin-2-yl]piperazin-2-yl]methanol\; SCHEMBL29164862 CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCNC[C@@H]3CO)nc21 Degrader C26H31N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-FELZZD WO2024041661-A1_UB-024 . CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCNC[C@H]3CCO)nc21 Degrader C27H33N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-OB38RM SCHEMBL27146229 2-[(2S)-1-[6-[(4-phenylphenyl)methylamino]-9-propan-2-ylpurin-2-yl]piperazin-2-yl]ethanol\; SCHEMBL27146229 CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCNC[C@@H]3CCO)nc21 Degrader C27H33N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-KOUISN WO2024041661-A1_UB-026 . CCN(C[C@H](C)N)c1nc(NCc2ccc(-c3ccccc3)cc2)c2ncn(C(C)C)c2n1 Degrader C26H33N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-4LE1EA SCHEMBL27138831 2-[(3R)-3-methylpiperazin-1-yl]-N-[(4-phenylphenyl)methyl]-9-propan-2-ylpurin-6-amine\; SCHEMBL27138831 CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCN[C@H](C)C3)nc21 Degrader C26H31N7 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-OYDDWE SCHEMBL29164944 [(2R)-4-[6-[(4-phenylphenyl)methylamino]-9-propan-2-ylpurin-2-yl]piperazin-2-yl]methanol\; SCHEMBL29164944 CC(C)n1cnc2c(NCc3ccc(-c4ccccc4)cc3)nc(N3CCN[C@@H](CO)C3)nc21 Degrader C26H31N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024041661-A1 TPD-UJ9L4F WO2024051766-A1_GT-04024 3-[7-[[4-[(4,4-difluoropiperidin-1-yl)methyl]phenyl]methylsulfanyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(SCc4ccc(CN5CCC(F)(F)CC5)cc4)cc(F)cc3C2=O)C(=O)N1 Degrader C26H26F3N3O3S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-Y158Z5 WO2024051766-A1_GT-04117 3-[5-fluoro-3-oxo-7-[[4-(piperidin-1-ylmethyl)phenyl]methylsulfanyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(SCc4ccc(CN5CCCCC5)cc4)cc(F)cc3C2=O)C(=O)N1 Degrader C26H28FN3O3S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-B6XP49 WO2024051766-A1_GT-04243 3-[7-[4-(1-adamantylamino)butylsulfanyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(SCCCCNC45CC6CC(CC(C6)C4)C5)cc(F)cc3C2=O)C(=O)N1 Degrader C27H34FN3O3S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-YJGCBK WO2024051766-A1_GT-04333 3-[7-[7-(1-adamantylamino)heptylsulfanyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(SCCCCCCCNC45CC6CC(CC(C6)C4)C5)cc(F)cc3C2=O)C(=O)N1 Degrader C30H40FN3O3S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-ZXU2CN WO2024051766-A1_GT-05341 . O=C1CCC(N2Cc3c(SCCCCCCCCN4CCOCC4)cc(F)cc3C2=O)C(=O)N1 Degrader C25H34FN3O4S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-UQPBVZ WO2024051766-A1_GT-05342 3-[7-[8-(diethylamino)octylsulfanyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CCN(CC)CCCCCCCCSc1cc(F)cc2c1CN(C1CCC(=O)NC1=O)C2=O Degrader C25H36FN3O3S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-6JQDPL WO2024051766-A1_GT-05343 3-[5-fluoro-3-oxo-7-(7-oxo-7-piperidin-1-ylheptyl)sulfanyl-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(SCCCCCCC(=O)N4CCCCC4)cc(F)cc3C2=O)C(=O)N1 Degrader C25H32FN3O4S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-J1F8FU WO2024051766-A1_GT-05344 3-[5-fluoro-3-oxo-7-(7-piperidin-1-ylheptylsulfanyl)-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(SCCCCCCCN4CCCCC4)cc(F)cc3C2=O)C(=O)N1 Degrader C25H34FN3O3S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-SXDGHZ WO2024051766-A1_GT-05407 3-[7-[7-(4,4-difluoropiperidin-1-yl)-7-oxoheptyl]sulfanyl-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(SCCCCCCC(=O)N4CCC(F)(F)CC4)cc(F)cc3C2=O)C(=O)N1 Degrader C25H30F3N3O4S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-XRPEIZ WO2024051766-A1_GT-05408 3-[7-[7-(4,4-difluoropiperidin-1-yl)heptylsulfanyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2Cc3c(SCCCCCCCN4CCC(F)(F)CC4)cc(F)cc3C2=O)C(=O)N1 Degrader C25H32F3N3O3S IKZF1;IKZF3;GSPT1 Q13422/Q9UKT9/P15170 CRBN WO-2024051766-A1 TPD-57HEWK SCHEMBL27312208 7-cyclopentyl-2-[[5-[4-[3-(1,3-dioxoisoindol-2-yl)propanoyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312208 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)CCN5C(=O)c6ccccc6C5=O)CC4)cn3)nc2n1C1CCCC1 Degrader C34H37N9O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-PPHRR4 SCHEMBL27312210 2-[[5-[4-(5-bromofuran-2-carbonyl)piperazin-1-yl]pyridin-2-yl]amino]-7-cyclopentyl-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312210 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)c5ccc(Br)o5)CC4)cn3)nc2n1C1CCCC1 Degrader C28H31BrN8O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-QDPD14 SCHEMBL27312216 tert-butyl N-[[4-[4-[6-[[7-cyclopentyl-6-(dimethylcarbamoyl)pyrrolo[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carbonyl]phenyl]methyl]carbamate\; SCHEMBL27312216 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)c5ccc(CNC(=O)OC(C)(C)C)cc5)CC4)cn3)nc2n1C1CCCC1 Degrader C36H45N9O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-7HUTCH WO2023025225-A1_202 (2R,3R)-3-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]-4-pyrrolidin-1-ylbutan-2-ol C[C@@H](O)[C@@H](CN1CCCC1)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C25H29F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-JTOBZH SCHEMBL27312219 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-(3-methylbenzotriazole-5-carbonyl)piperazin-1-yl]pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312219 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)c5ccc6nnn(C)c6c5)CC4)cn3)nc2n1C1CCCC1 Degrader C31H35N11O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-FND7XH WO2024086361-A1_104 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-(4-phenoxybenzoyl)piperazin-1-yl]pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)c5ccc(Oc6ccccc6)cc5)CC4)cn3)nc2n1C1CCCC1 Degrader C36H38N8O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-2C6J8W SCHEMBL27312386 7-cyclopentyl-2-[[5-[4-(4-ethynylbenzoyl)piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312386 C#Cc1ccc(C(=O)N2CCN(c3ccc(Nc4ncc5cc(C(=O)N(C)C)n(C6CCCC6)c5n4)nc3)CC2)cc1 Degrader C32H34N8O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-WIILHV WO2023025225-A1_206 (2R)-2-cyclopropyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]acetamide NC(=O)[C@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C1CC1 Degrader C22H21F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-P7F3CG SCHEMBL27316920 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-[3-(thiophen-2-ylmethyl)benzoyl]piperazin-1-yl]pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27316920 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)c5cccc(Cc6cccs6)c5)CC4)cn3)nc2n1C1CCCC1 Degrader C35H38N8O2S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-T7LCWA WO2023025225-A1_207 (2S,3R)-3-hydroxy-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide C[C@@H](O)[C@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C21H21F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-A3HSWI SCHEMBL27312395 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-[(E)-3-[3-(trifluoromethyl)phenyl]prop-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312395 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)/C=C/c5cccc(C(F)(F)F)c5)CC4)cn3)nc2n1C1CCCC1 Degrader C33H35F3N8O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-AL6PYB SCHEMBL27312544 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-[(E)-3-[2-(trifluoromethyl)phenyl]prop-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312544 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)/C=C/c5ccccc5C(F)(F)F)CC4)cn3)nc2n1C1CCCC1 Degrader C33H35F3N8O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-FQ1MTC SCHEMBL27312545 7-cyclopentyl-N,N-dimethyl-2-[[5-(4-prop-2-enoylpiperazin-1-yl)pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312545 C=CC(=O)N1CCN(c2ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc2)CC1 Degrader C26H32N8O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-AVM1XM WO2023025225-A1_21 4-(oxetan-3-yloxy)-N-[(4-pyrazin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidin-2-amine FC(F)(F)c1cnc(NCc2ccc(-c3cnccn3)cc2)nc1OC1COC1 Degrader C19H16F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-S92SX3 SCHEMBL27312547 2-[4-[4-[(Z)-2-acetamido-3-phenylprop-2-enoyl]piperazin-1-yl]anilino]-7-cyclopentyl-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312547 CC(=O)N/C(=C\c1ccccc1)C(=O)N1CCN(c2ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)cc2)CC1 Degrader C35H40N8O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-KRU8X6 SCHEMBL27317253 2-[[5-[4-(cyclopentene-1-carbonyl)piperazin-1-yl]pyridin-2-yl]amino]-7-cyclopentyl-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27317253 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)C5=CCCC5)CC4)cn3)nc2n1C1CCCC1 Degrader C29H36N8O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-6NYPYD WO2023025225-A1_210 (2R)-3-methyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide CC(C)[C@@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C22H23F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-YIVIBV WO2023025225-A1_211 (2R)-2-cyclobutyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]acetamide NC(=O)[C@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C1CCC1 Degrader C23H23F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-1KHX1C SCHEMBL27312550 2-[[5-[4-[(E)-3-[3,5-bis(trifluoromethyl)phenyl]prop-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]-7-cyclopentyl-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312550 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)/C=C/c5cc(C(F)(F)F)cc(C(F)(F)F)c5)CC4)cn3)nc2n1C1CCCC1 Degrader C34H34F6N8O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-Y9M0JL WO2023025225-A1_212 (2R,3S)-3-hydroxy-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide C[C@H](O)[C@@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C21H21F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-ZTWFI3 (E)-N,N-diethyl-3-[4-(trifluoromethyl)phenyl]prop-2-enamide SCHEMBL27315285 CCN(CC)C(=O)/C=C/c1ccc(C(F)(F)F)cc1 Degrader C14H16F3NO BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-D5B85E (E)-1-piperazin-1-yl-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one SCHEMBL16599253; VUYDUVXRRRSVSW-ZZXKWVIFSA-N; EN300-39919366; (2E)-1-(piperazin-1-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one; (E)-1-piperazin-1-yl-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one O=C(/C=C/c1ccc(C(F)(F)F)cc1)N1CCNCC1 Degrader C14H15F3N2O BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-4XRS4H WO2023025225-A1_213 (2R,3R)-3-hydroxy-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butanamide C[C@@H](O)[C@@H](Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F)C(N)=O Degrader C21H21F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-VX9ZUN AKOS017052526 (E)-1-(4-phenylpiperazin-1-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one\; SCHEMBL27315288; AKOS017052526 O=C(/C=C/c1ccc(C(F)(F)F)cc1)N1CCN(c2ccccc2)CC1 Degrader C20H19F3N2O BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-Y601GS WO2023025225-A1_214 4-N-[(2R)-1-aminobutan-2-yl]-2-N-[(4-pyridin-2-ylphenyl)methyl]-5-(trifluoromethyl)pyrimidine-2,4-diamine CC[C@H](CN)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H23F3N6 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-LGX4CH SCHEMBL27315289 (E)-1-(4-pyridin-3-ylpiperazin-1-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one\; SCHEMBL27315289 O=C(/C=C/c1ccc(C(F)(F)F)cc1)N1CCN(c2cccnc2)CC1 Degrader C19H18F3N3O BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-Y0PDZ8 SCHEMBL27312712 (E)-1-[4-[6-(pyrimidin-2-ylamino)pyridin-3-yl]piperazin-1-yl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one\; SCHEMBL27312712 O=C(/C=C/c1ccc(C(F)(F)F)cc1)N1CCN(c2ccc(Nc3ncccn3)nc2)CC1 Degrader C23H21F3N6O BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-VTRAWX (E)-N,N-diethyl-4-(4-methoxyphenyl)-4-oxobut-2-enamide SCHEMBL27315290 CCN(CC)C(=O)/C=C/C(=O)c1ccc(OC)cc1 Degrader C15H19NO3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-FKWGPW (E)-1-(4-methoxyphenyl)-4-(piperazin-1-yl)but-2-ene-1,4-dione SCHEMBL27315291; EX-A12101; JP-2-196; EN300-43351076; (2E)-1-(4-methoxyphenyl)-4-(piperazin-1-yl)but-2-ene-1,4-dione; (E)-1-(4-methoxyphenyl)-4-(piperazin-1-yl)but-2-ene-1,4-dione; 3036530-35-2 COc1ccc(C(=O)/C=C/C(=O)N2CCNCC2)cc1 Degrader C15H18N2O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-ZL4KMU (E)-1-(4-methoxyphenyl)-4-(4-phenylpiperazin-1-yl)but-2-ene-1,4-dione SCHEMBL27315295 COc1ccc(C(=O)/C=C/C(=O)N2CCN(c3ccccc3)CC2)cc1 Degrader C21H22N2O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-OAPN0V SCHEMBL27315297 (E)-1-(4-methoxyphenyl)-4-(4-pyridin-3-ylpiperazin-1-yl)but-2-ene-1,4-dione\; SCHEMBL27315297 COc1ccc(C(=O)/C=C/C(=O)N2CCN(c3cccnc3)CC2)cc1 Degrader C20H21N3O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-XWD9Z1 SCHEMBL27312723 (E)-1-(4-methoxyphenyl)-4-[4-[6-(pyrimidin-2-ylamino)pyridin-3-yl]piperazin-1-yl]but-2-ene-1,4-dione\; SCHEMBL27312723 COc1ccc(C(=O)/C=C/C(=O)N2CCN(c3ccc(Nc4ncccn4)nc3)CC2)cc1 Degrader C24H24N6O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-3A6AZW SCHEMBL27312889 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-[4-[(E)-3-[4-(trifluoromethyl)phenyl]prop-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]pyrido[2,3-d]pyrimidin-7-one\; SCHEMBL27312889 CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(C(=O)/C=C/c5ccc(C(F)(F)F)cc5)CC4)cn3)nc2n(C2CCCC2)c1=O Degrader C34H34F3N7O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-0JASG3 SCHEMBL27312892 7-cyclopentyl-2-[[5-[4-[4-(4-methoxyphenyl)-4-oxobutanoyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27312892 COc1ccc(C(=O)CCC(=O)N2CCN(c3ccc(Nc4ncc5cc(C(=O)N(C)C)n(C6CCCC6)c5n4)nc3)CC2)cc1 Degrader C34H40N8O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-O19EGY WO2024086361-A1_136 (E)-1-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione COc1ccc(C(=O)/C=C/C(=O)N2CCN(c3ccc(Nc4ncc5c(C)c(C(C)=O)c(=O)n(C6CCCC6)c5n4)nc3)CC2)cc1 Degrader C35H37N7O5 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-8QJ3PQ SCHEMBL27313051 1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(4-methoxyphenyl)butane-1,4-dione\; SCHEMBL27313051 COc1ccc(C(=O)CCC(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)cc1 Degrader C34H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-PTBK5C SCHEMBL27313053 (E)-N-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethyl]-4-(4-methoxyphenyl)-4-oxobut-2-enamide\; SCHEMBL27313053 COc1ccc(C(=O)/C=C/C(=O)NCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)cc1 Degrader C32H31ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-SS0MBB SCHEMBL27313055 (E)-4-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-1-(4-methoxyphenyl)-2-methylbut-2-ene-1,4-dione\; SCHEMBL27313055 COc1ccc(C(=O)/C(C)=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)cc1 Degrader C35H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-8AGTHK SCHEMBL27313164 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-phenylbut-2-ene-1,4-dione\; SCHEMBL27313164 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N1CCN(C(=O)/C=C/C(=O)c3ccccc3)CC1)c1nnc(C)n1-2 Degrader C33H31ClN6O3S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-2AZYN9 WO2023025225-A1_25 (2R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butan-1-ol CC[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H22F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-YI0QJ0 SCHEMBL27313170 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(4-methoxyphenyl)-2-methylbut-2-ene-1,4-dione\; SCHEMBL27313170 COc1ccc(C(=O)/C=C(\C)C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)cc1 Degrader C35H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-X0IPN1 SCHEMBL27313172 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(2-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27313172 COc1ccccc1C(=O)/C=C/C(=O)N1CCN(C(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)CC1 Degrader C34H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-H3OJN0 SCHEMBL27313174 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(3-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27313174 COc1cccc(C(=O)/C=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)c1 Degrader C34H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-WJ542B WO2024086361-A1_144 . COc1ccc(C(=O)/C=C(\C#N)C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)cc1 Degrader C35H32ClN7O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-LALG5M (E)-1-(4-methoxyphenyl)-2-methyl-4-piperazin-1-ylbut-2-ene-1,4-dione SCHEMBL27315299 COc1ccc(C(=O)/C(C)=C/C(=O)N2CCNCC2)cc1 Degrader C16H20N2O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-PM4JC6 SCHEMBL27313310 7-cyclopentyl-2-[[5-[4-[(E)-4-(4-methoxyphenyl)-3-methyl-4-oxobut-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27313310 COc1ccc(C(=O)/C(C)=C/C(=O)N2CCN(c3ccc(Nc4ncc5cc(C(=O)N(C)C)n(C6CCCC6)c5n4)nc3)CC2)cc1 Degrader C35H40N8O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-7OP69O (E)-1-(2-methoxyphenyl)-4-piperazin-1-ylbut-2-ene-1,4-dione SCHEMBL27318400 COc1ccccc1C(=O)/C=C/C(=O)N1CCNCC1 Degrader C15H18N2O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-UROT2N SCHEMBL27313313 7-cyclopentyl-2-[[5-[4-[(E)-4-(2-methoxyphenyl)-4-oxobut-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27313313 COc1ccccc1C(=O)/C=C/C(=O)N1CCN(c2ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc2)CC1 Degrader C34H38N8O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-2N1D7A (E)-1-(2-fluorophenyl)-4-piperazin-1-ylbut-2-ene-1,4-dione SCHEMBL27318403 O=C(/C=C/C(=O)N1CCNCC1)c1ccccc1F Degrader C14H15FN2O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-74HZBY (E)-1-(4-fluorophenyl)-4-piperazin-1-ylbut-2-ene-1,4-dione SCHEMBL27318405 O=C(/C=C/C(=O)N1CCNCC1)c1ccc(F)cc1 Degrader C14H15FN2O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-PDEMB7 WO2023025225-A1_35 . CN1CCC(Oc2nc(NCc3ccc(-c4ccccn4)cc3)ncc2C(F)F)CC1 Degrader C23H25F2N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-Z3RQS8 SCHEMBL27313316 7-cyclopentyl-2-[[5-[4-[(E)-4-(4-fluorophenyl)-4-oxobut-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27313316 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)/C=C/C(=O)c5ccc(F)cc5)CC4)cn3)nc2n1C1CCCC1 Degrader C33H35FN8O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-90H8QM (E)-1-phenyl-4-piperazin-1-ylbut-2-ene-1,4-dione SCHEMBL27318407 O=C(/C=C/C(=O)N1CCNCC1)c1ccccc1 Degrader C14H16N2O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-LN9JZ9 SCHEMBL27315386 tert-butyl 4-[(E)-2-cyano-4-(4-methoxyphenyl)-4-oxobut-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315386 COc1ccc(C(=O)/C=C(\C#N)C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)cc1 Degrader C21H25N3O5 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-N2CKHR SCHEMBL27315387 tert-butyl 4-[(E)-4-(2-bromophenyl)-4-oxobut-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315387 CC(C)(C)OC(=O)N1CCN(C(=O)/C=C/C(=O)c2ccccc2Br)CC1 Degrader C19H23BrN2O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-KSEJYC SCHEMBL27315388 tert-butyl 4-[(E)-4-(3-fluorophenyl)-4-oxobut-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315388 CC(C)(C)OC(=O)N1CCN(C(=O)/C=C/C(=O)c2cccc(F)c2)CC1 Degrader C19H23FN2O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-30OW2B SCHEMBL27315395 tert-butyl 4-[(E)-4-(3-methoxyphenyl)-4-oxobut-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315395 COc1cccc(C(=O)/C=C/C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1 Degrader C20H26N2O5 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-3277F7 SCHEMBL27315474 tert-butyl 4-[(E)-4-(3-methylphenyl)-4-oxobut-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315474 Cc1cccc(C(=O)/C=C/C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1 Degrader C20H26N2O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-2VTRKM WO2023025225-A1_40 N-[[4-(4-methylpyridin-2-yl)phenyl]methyl]-4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-amine Cc1ccnc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C21H19F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-1Y99PF SCHEMBL27313318 2-[[5-[4-[(E)-4-(2-chlorophenyl)-4-oxobut-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]-7-cyclopentyl-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27313318 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)/C=C/C(=O)c5ccccc5Cl)CC4)cn3)nc2n1C1CCCC1 Degrader C33H35ClN8O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-S03JVN SCHEMBL27313320 2-[[5-[4-[(E)-4-(2-bromophenyl)-4-oxobut-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]-7-cyclopentyl-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27313320 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)/C=C/C(=O)c5ccccc5Br)CC4)cn3)nc2n1C1CCCC1 Degrader C33H35BrN8O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-XM85CJ WO2023025225-A1_43 [2-[4-[[[4-(Oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]pyridin-4-yl]methanol OCc1ccnc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C21H19F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-R47CF6 SCHEMBL27313469 7-cyclopentyl-2-[[5-[4-[(E)-4-(4-methoxyphenyl)-2-methyl-4-oxobut-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27313469 COc1ccc(C(=O)/C=C(\C)C(=O)N2CCN(c3ccc(Nc4ncc5cc(C(=O)N(C)C)n(C6CCCC6)c5n4)nc3)CC2)cc1 Degrader C35H40N8O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-RM6WYZ SCHEMBL27315475 tert-butyl 4-[(E)-4-(2-chlorophenyl)-4-oxobut-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315475 CC(C)(C)OC(=O)N1CCN(C(=O)/C=C/C(=O)c2ccccc2Cl)CC1 Degrader C19H23ClN2O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-K5K924 SCHEMBL27315476 tert-butyl 4-[(E)-4-oxo-4-[3-(trifluoromethyl)phenyl]but-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315476 CC(C)(C)OC(=O)N1CCN(C(=O)/C=C/C(=O)c2cccc(C(F)(F)F)c2)CC1 Degrader C20H23F3N2O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-HGYOSP SCHEMBL27315477 tert-butyl 4-[(E)-4-(3-bromophenyl)-4-oxobut-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315477 CC(C)(C)OC(=O)N1CCN(C(=O)/C=C/C(=O)c2cccc(Br)c2)CC1 Degrader C19H23BrN2O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-2VZM6R SCHEMBL27315478 tert-butyl 4-[(E)-4-(4-bromophenyl)-4-oxobut-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315478 CC(C)(C)OC(=O)N1CCN(C(=O)/C=C/C(=O)c2ccc(Br)cc2)CC1 Degrader C19H23BrN2O4 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-J2MQ0R SCHEMBL27313473 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-[(E)-4-oxo-4-[3-(trifluoromethyl)phenyl]but-2-enoyl]piperazin-1-yl]pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27313473 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)/C=C/C(=O)c5cccc(C(F)(F)F)c5)CC4)cn3)nc2n1C1CCCC1 Degrader C34H35F3N8O3 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-2ATTWD SCHEMBL27315480 tert-butyl 4-[(E)-4-(4-methoxyphenyl)-2-methyl-4-oxobut-2-enoyl]piperazine-1-carboxylate\; SCHEMBL27315480 COc1ccc(C(=O)/C=C(\C)C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)cc1 Degrader C21H28N2O5 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-JWCKCZ SCHEMBL27313476 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-(4-pyrimidin-2-ylbenzoyl)piperazin-1-yl]pyridin-2-yl]amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide\; SCHEMBL27313476 CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)c5ccc(-c6ncccn6)cc5)CC4)cn3)nc2n1C1CCCC1 Degrader C34H36N10O2 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-WCN19P SCHEMBL27313480 N-[4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[2-[[3-[[(E)-4-(4-methoxyphenyl)-4-oxobut-2-enoyl]amino]cyclobutyl]amino]-2-oxoethyl]piperazin-1-yl]pyridazine-3-carboxamide\; SCHEMBL27313480 COc1ccc(C(=O)/C=C/C(=O)N[C@H]2C[C@H](NC(=O)CN3CCN(c4ccc(C(=O)NC5CCC(Oc6ccc(C#N)c(Cl)c6)CC5)nn4)CC3)C2)cc1 Degrader C39H43ClN8O6 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-ZMK26N WO2024086361-A1_201 . COc1ccc(C(=O)/C=C/C(=O)N[C@H]2C[C@H](NC(=O)CN3CCN(c4ccc(C(=O)NC5CCC(Oc6ccc(C#N)c(Cl)c6)CC5)nn4)CC3)C2)c(F)c1 Degrader C39H42ClFN8O6 BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-MIJ2Q5 SCHEMBL27320283 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(4-fluorophenyl)but-2-ene-1,4-dione\; SCHEMBL27320283 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N1CCN(C(=O)/C=C/C(=O)c3ccc(F)cc3)CC1)c1nnc(C)n1-2 Degrader C33H30ClFN6O3S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-52I1SQ SCHEMBL27313492 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(3-oxo-4H-1,4-benzoxazin-6-yl)but-2-ene-1,4-dione\; SCHEMBL27313492 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N1CCN(C(=O)/C=C/C(=O)c3ccc4c(c3)NC(=O)CO4)CC1)c1nnc(C)n1-2 Degrader C35H32ClN7O5S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-SH2S2O SCHEMBL27313607 (E)-N-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]cyclobutyl]-4-oxo-4-phenylbut-2-enamide\; SCHEMBL27313607 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N[C@H]1C[C@H](NC(=O)/C=C/C(=O)c3ccccc3)C1)c1nnc(C)n1-2 Degrader C33H31ClN6O3S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-OP7IXH SCHEMBL27313608 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(6-methoxypyridin-3-yl)but-2-ene-1,4-dione\; SCHEMBL27313608 COc1ccc(C(=O)/C=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)cn1 Degrader C33H32ClN7O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-WUVE2S WO-2024086361-A1_206 (E)-N-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]cyclobutyl]-4-(6-methoxypyridin-3-yl)-4-oxobut-2-enamide\; SCHEMBL27320407; SCHEMBL27320499 COc1ccc(C(=O)/C=C/C(=O)N[C@H]2C[C@@H](NC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)C2)cn1 Degrader C33H32ClN7O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-SY5FWT WO-2024086361-A1_207 (E)-N-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]cyclobutyl]-4-(6-methoxypyridin-3-yl)-4-oxobut-2-enamide\; SCHEMBL27320407; SCHEMBL27320499 COc1ccc(C(=O)/C=C/C(=O)N[C@H]2C[C@H](NC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)C2)cn1 Degrader C33H32ClN7O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-F6VOXJ SCHEMBL27313615 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(2,3-dihydro-1-benzofuran-6-yl)but-2-ene-1,4-dione\; SCHEMBL27313615 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N1CCN(C(=O)/C=C/C(=O)c3ccc4c(c3)OCC4)CC1)c1nnc(C)n1-2 Degrader C35H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-MLVMI5 SCHEMBL27320624 (E)-N-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]cyclobutyl]-4-(2,3-dihydro-1-benzofuran-6-yl)-4-oxobut-2-enamide\; SCHEMBL27320624 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N[C@H]1C[C@H](NC(=O)/C=C/C(=O)c3ccc4c(c3)OCC4)C1)c1nnc(C)n1-2 Degrader C35H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-9UV0FT SCHEMBL27313786 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(2,3-dihydro-1-benzofuran-5-yl)but-2-ene-1,4-dione\; SCHEMBL27313786 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N1CCN(C(=O)/C=C/C(=O)c3ccc4c(c3)CCO4)CC1)c1nnc(C)n1-2 Degrader C35H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-ERWJCJ SCHEMBL27320746 (E)-N-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]cyclobutyl]-4-(2,3-dihydro-1-benzofuran-5-yl)-4-oxobut-2-enamide\; SCHEMBL27320746 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N[C@H]1C[C@H](NC(=O)/C=C/C(=O)c3ccc4c(c3)CCO4)C1)c1nnc(C)n1-2 Degrader C35H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-Z2EEJQ SCHEMBL27313794 (E)-1-[(1S,5R)-6-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-3,6-diazabicyclo[3.2.0]heptan-3-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27313794 COc1ccc(C(=O)/C=C/C(=O)N2C[C@H]3CN(C(=O)C[C@@H]4N=C(c5ccc(Cl)cc5)c5c(sc(C)c5C)-n5c(C)nnc54)[C@H]3C2)cc1 Degrader C35H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-DX6UEB SCHEMBL27320871 (E)-1-[(1R,5S)-6-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-3,6-diazabicyclo[3.2.0]heptan-3-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27320871 COc1ccc(C(=O)/C=C/C(=O)N2C[C@@H]3CN(C(=O)C[C@@H]4N=C(c5ccc(Cl)cc5)c5c(sc(C)c5C)-n5c(C)nnc54)[C@@H]3C2)cc1 Degrader C35H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-RAAMBI SCHEMBL27320873 (E)-1-[(2S)-4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-2-methylpiperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27320873 COc1ccc(C(=O)/C=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)C[C@@H]2C)cc1 Degrader C35H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-PMY2FL SCHEMBL27320874 (E)-1-[(2R,6S)-4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-2,6-dimethylpiperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27320874 COc1ccc(C(=O)/C=C/C(=O)N2[C@H](C)CN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)C[C@@H]2C)cc1 Degrader C36H37ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-8KRQNX WO2023025225-A1_64 [2-Methyl-6-[4-[[[4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]pyridin-4-yl]methanol Cc1cc(CO)cc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)n1 Degrader C22H21F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-YBZV2B SCHEMBL27320989 (E)-1-[(3S)-4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-3-methylpiperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27320989 COc1ccc(C(=O)/C=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)[C@@H](C)C2)cc1 Degrader C35H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-LB44UI SCHEMBL27320993 (E)-1-[(2R)-4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-2-methylpiperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27320993 COc1ccc(C(=O)/C=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)C[C@H]2C)cc1 Degrader C35H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-DBERHG SCHEMBL27321136 (E)-1-[(3R)-4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-3-methylpiperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27321136 COc1ccc(C(=O)/C=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)[C@H](C)C2)cc1 Degrader C35H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-A8OFMB SCHEMBL27314006 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-1,4-diazepan-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27314006 COc1ccc(C(=O)/C=C/C(=O)N2CCCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)cc1 Degrader C35H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-PDPIV3 WO2023025225-A1_69 [4-Methyl-6-[4-[[[4-(oxetan-3-yloxy)-5-(trifluoromethyl)pyrimidin-2-yl]amino]methyl]phenyl]pyridin-2-yl]methanol Cc1cc(CO)nc(-c2ccc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)cc2)c1 Degrader C22H21F3N4O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-KRDXWB SCHEMBL27321140 (E)-1-[2-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-2,6-diazabicyclo[3.2.1]octan-6-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27321140 COc1ccc(C(=O)/C=C/C(=O)N2CC3CC2CCN3C(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)cc1 Degrader C36H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-JJHCBU SCHEMBL27314008 (E)-1-[7-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-4,7-diazaspiro[2.5]octan-4-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27314008 COc1ccc(C(=O)/C=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC23CC3)cc1 Degrader C36H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-L764CZ WO2023025225-A1_70 (1R,2R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]cyclopentan-1-ol O[C@@H]1CCC[C@H]1Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C22H22F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-PNL4BQ WO-2024086361-A1_222 (E)-N-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]cyclobutyl]-4-(4-methoxyphenyl)-4-oxobut-2-enamide\; SCHEMBL27314011; SCHEMBL27321274 COc1ccc(C(=O)/C=C/C(=O)NC2CC(NC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)C2)cc1 Degrader C34H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-RVATEU WO-2024086361-A1_223 (E)-N-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]cyclobutyl]-4-(4-methoxyphenyl)-4-oxobut-2-enamide\; SCHEMBL27314011; SCHEMBL27321274 COc1ccc(C(=O)/C=C/C(=O)N[C@H]2C[C@H](NC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)C2)cc1 Degrader C34H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-OR7TKC SCHEMBL27314115 (E)-1-[7-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-2,7-diazaspiro[4.4]nonan-2-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27314115 COc1ccc(C(=O)/C=C/C(=O)N2CCC3(CCN(C(=O)C[C@@H]4N=C(c5ccc(Cl)cc5)c5c(sc(C)c5C)-n5c(C)nnc54)C3)C2)cc1 Degrader C37H37ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-UTPETM SCHEMBL27314121 (E)-1-[5-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27314121 COc1ccc(C(=O)/C=C/C(=O)N2CC3CCN(C(=O)C[C@@H]4N=C(c5ccc(Cl)cc5)c5c(sc(C)c5C)-n5c(C)nnc54)CC3C2)cc1 Degrader C37H37ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-3YSDGL SCHEMBL27314126 (E)-1-[5-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27314126 COc1ccc(C(=O)/C=C/C(=O)N2CC3CCC2CN3C(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)cc1 Degrader C36H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-HYAV5V SCHEMBL27314131 (E)-1-[7-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-2,7-diazaspiro[3.5]nonan-2-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27314131 COc1ccc(C(=O)/C=C/C(=O)N2CC3(CCN(C(=O)C[C@@H]4N=C(c5ccc(Cl)cc5)c5c(sc(C)c5C)-n5c(C)nnc54)CC3)C2)cc1 Degrader C37H37ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-7B9KUD SCHEMBL27314137 (E)-1-[6-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-3,6-diazabicyclo[3.2.2]nonan-3-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27314137 COc1ccc(C(=O)/C=C/C(=O)N2CC3CCC(C2)N(C(=O)C[C@@H]2N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc42)C3)cc1 Degrader C37H37ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-5MJ80S SCHEMBL27321566 (E)-1-[7-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-3,7-diazabicyclo[3.3.1]nonan-3-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27321566 COc1ccc(C(=O)/C=C/C(=O)N2CC3CC(C2)CN(C(=O)C[C@@H]2N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc42)C3)cc1 Degrader C37H37ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-ZXUL7O SCHEMBL27321568 (E)-1-[2-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27321568 COc1ccc(C(=O)/C=C/C(=O)N2CC3CN(C(=O)C[C@@H]4N=C(c5ccc(Cl)cc5)c5c(sc(C)c5C)-n5c(C)nnc54)CC3C2)cc1 Degrader C36H35ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-1JXXGU SCHEMBL27321681 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27321681 COc1ccc(C(=O)/C=C/C(=O)N2CCC3(CC2)CN(C(=O)C[C@@H]2N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc42)CCO3)cc1 Degrader C38H39ClN6O5S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-2WQF6K SCHEMBL27321683 (Z)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27321683 COc1ccc(C(=O)/C=C\C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)cc1 Degrader C34H33ClN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-1WQCO1 SCHEMBL27321814 (E)-1-[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]-4-(2-fluoro-4-methoxyphenyl)but-2-ene-1,4-dione\; SCHEMBL27321814 COc1ccc(C(=O)/C=C/C(=O)N2CCN(C(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)CC2)c(F)c1 Degrader C34H32ClFN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-J9QB3A SCHEMBL27314238 (E)-N-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]cyclobutyl]-4-(2-fluoro-4-methoxyphenyl)-4-oxobut-2-enamide\; SCHEMBL27314238 COc1ccc(C(=O)/C=C/C(=O)N[C@H]2C[C@H](NC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)C2)c(F)c1 Degrader C34H32ClFN6O4S BRD4 long;BRD4 short;CDK4 O60885-1/O60885-2/P11802 RNF126 WO-2024086361-A1 TPD-N76G5L WO2024109918-A1_1 . O=C(/C=C/c1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2)Nc1cc(OC(F)(F)F)ccc1F Degrader C23H17F4N3O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-N7SUG4 WO2024109918-A1_10 . O=C1CCC(N2Cc3cc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)cnc3C2=O)C(=O)N1 Degrader C23H19F4N5O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-GTLQQ4 WO2024109918-A1_12-1 . O=C1CCC(N2Cc3cc([C@H]4C[C@H](C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)ccc3C2=O)C(=O)N1 Degrader C25H21F4N3O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-VF5C6F WO2024109918-A1_12-2 . O=C1CCC(N2Cc3cc([C@H]4C[C@@H](C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)ccc3C2=O)C(=O)N1 Degrader C25H21F4N3O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-DZV232 WO2023025225-A1_85 (2R)-3,3-dimethyl-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]butan-1-ol CC(C)(C)[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C23H26F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-KMD5EP WO2024109918-A1_16 . O=C1CCC(N2Cc3sc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)cc3C2=O)C(=O)N1 Degrader C22H18F4N4O5S GSPT1 P15170 CRBN WO-2024109918-A1 TPD-LV9F6V WO2024109918-A1_17 . O=C1CCC(N2Cc3cc(N4CC(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)ccc3C2=O)C(=O)N1 Degrader C24H20F4N4O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-P2BFFF WO2024109918-A1_18 . O=C1CCC(N2Cc3nc(N4CC(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)ccc3C2=O)C(=O)N1 Degrader C23H19F4N5O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-4OUEFX WO2024109918-A1_19 . O=C1CCC(N2Cc3ccc(N4CC(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)cc3C2=O)C(=O)N1 Degrader C24H20F4N4O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-WO0YLH WO2024109918-A1_2 . O=C1CCC(N2Cc3ccc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)cc3C2=O)C(=O)N1 Degrader C24H20F4N4O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-ECHE5W WO2024109918-A1_20 . O=C1CCC(N2Cc3cc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)sc3C2=O)C(=O)N1 Degrader C22H18F4N4O5S GSPT1 P15170 CRBN WO-2024109918-A1 TPD-9XGKLV WO2023025225-A1_91 (1S,2R)-2-[[2-[(4-pyridin-2-ylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]cyclobutan-1-ol O[C@H]1CC[C@H]1Nc1nc(NCc2ccc(-c3ccccn3)cc2)ncc1C(F)(F)F Degrader C21H20F3N5O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2023025225-A1 TPD-R8HX47 WO2024109918-A1_21 . O=C1CCC(N2Cc3cc(N4CCN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C25H23F4N5O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-YTA0F0 WO2024109918-A1_22 . O=C1CCC(N2C(=O)c3ccc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)cc3C23CC3)C(=O)N1 Degrader C26H22F4N4O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-C7I8M6 WO2024109918-A1_23 . O=C1CCC(N2Cc3cnc(N4CC(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)cc3C2=O)C(=O)N1 Degrader C23H19F4N5O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-4U5VGH WO2024109918-A1_24 . O=C1CCC(N2Cc3sc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)nc3C2=O)C(=O)N1 Degrader C21H17F4N5O5S GSPT1 P15170 CRBN WO-2024109918-A1 TPD-BUUCEI WO2024109918-A1_25 . O=C1CCC(N2Cc3nc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)sc3C2=O)C(=O)N1 Degrader C21H17F4N5O5S GSPT1 P15170 CRBN WO-2024109918-A1 TPD-OUQ374 WO2024109918-A1_26 . O=C1CCC(N2Cc3ncc(N4CC(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)cc3C2=O)C(=O)N1 Degrader C23H19F4N5O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-RQYCUE WO2024109918-A1_27-1 . O=C1CCC(N2Cc3sc([C@H]4C[C@@H](C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)nc3C2=O)C(=O)N1 Degrader C22H18F4N4O5S GSPT1 P15170 CRBN WO-2024109918-A1 TPD-75MJXP WO2024109918-A1_27-2 . O=C1CCC(N2Cc3sc([C@H]4C[C@H](C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)nc3C2=O)C(=O)N1 Degrader C22H18F4N4O5S GSPT1 P15170 CRBN WO-2024109918-A1 TPD-GFX0D5 WO2024125437-A1_1 . O=C1CCC(N2Cc3ccc(COC(=O)Nc4cc(C5=CCOCC5)c(Cl)cc4F)cc3C2=O)C(=O)N1 Degrader C26H23ClFN3O6 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-L7YY1B WO2024125437-A1_10 . O=C1CCC(N2Cc3ccc(COC(=O)N(CC(F)F)c4cc(OC(F)(F)F)ccc4F)cc3C2=O)C(=O)N1 Degrader C24H19F6N3O6 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-XUW2XL WO2024125437-A1_11 . O=C1CCC(N2Cc3ccc(COC(=O)Nc4cc(N5CC6(CCOCC6)C5)c(Cl)cc4F)cc3C2=O)C(=O)N1 Degrader C28H28ClFN4O6 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-ZSGS23 WO2024125437-A1_12 . CC1=Nc2c(F)cc(NC(=O)OCc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)cc2C12CCCC2 Degrader C28H27FN4O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-P16H5Y WO2024125437-A1_13 . O=C1CCC(n2c(=O)oc3c(COC(=O)Nc4cc(OC(F)(F)F)ccc4F)cccc32)C(=O)N1 Degrader C21H15F4N3O7 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-9RTLAI WO2024125437-A1_14 . O=C(Nc1cc(OC(F)(F)F)ccc1F)OCc1ccc2c(c1)C(=O)N(C1CCS(=O)(=O)NC1=O)C2 Degrader C21H17F4N3O7S GSPT1 P15170 CRBN WO-2024125437-A1 TPD-WY85FR WO2024125437-A1_15 . O=C1CCC(N2Cc3csc(COC(=O)Nc4cc(OC(F)(F)F)ccc4F)c3C2=O)C(=O)N1 Degrader C20H15F4N3O6S GSPT1 P15170 CRBN WO-2024125437-A1 TPD-JB5Z1L WO2024125437-A1_16 . O=C1CCC(n2ncc3ccc(COC(=O)Nc4cc(C#CC5CC5)c(Cl)cc4F)cc3c2=O)C(=O)N1 Degrader C26H20ClFN4O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-WG7YX1 WO2024125437-A1_17 . O=C1CCC(n2oc3ccc(COC(=O)Nc4cc(OC(F)(F)F)ccc4F)cc3c2=O)C(=O)N1 Degrader C21H15F4N3O7 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-63B8KX WO2024125437-A1_18 . O=C1CCC(n2c(=O)oc3cc(COC(=O)Nc4cc(OC(F)(F)F)ccc4F)ccc32)C(=O)N1 Degrader C21H15F4N3O7 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-YD4TJ3 WO2024125437-A1_19 . O=C1CCC(N2Cc3ccc(COC(=O)Nn4ccc(Cl)c(C#CC5CC5)c4=O)cc3C2=O)C(=O)N1 Degrader C25H21ClN4O6 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-BR6S8A WO2024125437-A1_2 . O=C1CCC(N2Cc3ccc(COC(=O)Nc4ccc(Cl)c(C#CC5CC5)c4)cc3C2=O)C(=O)N1 Degrader C26H22ClN3O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-YX1H5G WO2024125437-A1_20 . O=C(C#Cc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)Nc1cc(OC(F)(F)F)ccc1F Degrader C23H15F4N3O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-CCBTVU WO2024125437-A1_21 . O=C1CCC(N2Cc3ccc(COc4cc(C(=O)Nc5ccccc5)n(C(F)F)n4)cc3C2=O)C(=O)N1 Degrader C25H21F2N5O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-VJ4QLX WO2024125437-A1_22 . O=C1CCC(N2Cc3ccc(COC(=O)Nc4cc5c(cc4F)C4(CC4)CO5)cc3C2=O)C(=O)N1 Degrader C25H22FN3O6 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-5OZJCR WO2024125437-A1_23 . CN1CC2(CCOCC2)c2cc(NC(=O)OCc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)cc(F)c21 Degrader C28H29FN4O6 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-TCJXYP WO2024125551-A1_1 . FC(F)(F)c1cnc(NCc2ccc3c(c2)[nH]c2ccccc23)nc1OC1COC1 Degrader C21H17F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-EUD09L WO2024125551-A1_10 . FC(F)(F)c1cnc(NCc2ccc3c(n2)[nH]c2cccnc23)nc1OC1COC1 Degrader C19H15F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-O75JPC WO2024125551-A1_100 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C(F)(F)F)C(=O)N(C)C Degrader C24H26F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-IPXI0G WO2024125551-A1_101 . CN1CC[C@H](O)[C@H](Nc2nc(NCc3ccc4c(c3)[nH]c3c(CO)ccnc34)ncc2C(F)(F)F)C1 Degrader C24H26F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-3W6UT6 WO2024125551-A1_102 . N#Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CN(CCCO)CC[C@@H]4O)n3)ccc12 Degrader C26H27F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-RLFMT1 WO2024125551-A1_103 . N#Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CN(C5COC5)CC[C@@H]4O)n3)ccc12 Degrader C26H25F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-ZNC1YK WO2024125551-A1_104 . CNCC(=O)N1CC[C@H](O)[C@H](Nc2nc(NCc3ccc4c(c3)[nH]c3c(C#N)ccnc34)ncc2C(F)(F)F)C1 Degrader C26H26F3N9O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-0LNPDG WO2024125551-A1_11 . C[C@@H](O)[C@@H](C)Oc1nc(NCc2ccc3c(c2)[nH]c2cccnc23)ncc1C(F)(F)F Degrader C21H20F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-YTQJQ2 WO2024125551-A1_12 . C[C@@H](O)[C@@H](C)Oc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C(F)(F)F Degrader C22H22F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-BSCJ7R WO2024125551-A1_13 . C[C@@H](O)[C@@H](CO)Nc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C(F)(F)F Degrader C22H23F3N6O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-ICZMU1 WO2024125551-A1_14 . FC(F)(F)c1cnc(NCc2ccc3c(c2)[nH]c2ncsc23)nc1OC1COC1 Degrader C18H14F3N5O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-FFGRXR WO2024125551-A1_15 . N#Cc1cc(CNc2ncc(C(F)(F)F)c(OC3COC3)n2)cc2[nH]c3cccnc3c12 Degrader C21H15F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-Z0GIO8 WO2024125551-A1_16 . Cc1cc2c(cc1CNc1ncc(C(F)(F)F)c(OC3COC3)n1)[nH]c1cccnc12 Degrader C21H18F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-5KWJQR WO2024125551-A1_17 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C22H22F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-XILW5Q WO2024125551-A1_18 . C[C@@H](O)[C@@H](C)Nc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C(F)(F)F Degrader C22H23F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-RK5HQF WO2024125551-A1_19 . NCc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)ccc12 Degrader C21H19F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-GUXSDJ WO2024125551-A1_2 . FC(F)(F)C1=C(OC2COC2)NC(NCc2ccc3c4c([nH]c3c2)C=CCN4)N=C1 Degrader C20H20F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-PYCAJF WO2024125551-A1_20 . FC(F)(F)c1cnc(NCc2cc3[nH]c4cccnc4c3s2)nc1OC1COC1 Degrader C18H14F3N5O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-CX4EIV WO2024125551-A1_21 . Cc1cc(CNc2ncc(C(F)(F)F)c(OC3COC3)n2)cc2[nH]c3cccnc3c12 Degrader C21H18F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-N1LXYS WO2024125551-A1_22 . C[C@@H](O)[C@@H](C)Oc1nc(NCc2ccc3c(c2)[nH]c2ncsc23)ncc1C(F)(F)F Degrader C19H18F3N5O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-JJED9I WO2024125551-A1_23 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C(F)(F)F)[C@@H](C)O Degrader C23H25F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-ULJ6HQ WO2024125551-A1_24 . N#Cc1cccc2c3ccc(CNc4ncc(C(F)(F)F)c(OC5COC5)n4)cc3nn12 Degrader C21H15F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-C4Y7WZ WO2024125551-A1_25 . N#Cc1ccn2nc3cc(CNc4ncc(C(F)(F)F)c(OC5COC5)n4)ccc3c2c1 Degrader C21H15F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-JKQ029 WO2024125551-A1_26 . OCc1cccc2c3ccc(CNc4ncc(C(F)(F)F)c(OC5COC5)n4)cc3nn12 Degrader C21H18F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-R9BDX1 WO2024125551-A1_27 . C[C@@H](O)[C@@H](C)Oc1nc(NCc2ccc3c(c2)[nH]c2c(CN)ccnc23)ncc1C(F)(F)F Degrader C22H23F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-A8AG5F WO2024125551-A1_28 . NCc1cccc2c3ccc(CNc4ncc(C(F)(F)F)c(OC5COC5)n4)cc3nn12 Degrader C21H19F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-OEGW0X WO2024125551-A1_29 . FC(F)(F)c1cnc(NCc2ccc3c(c2)[nH]c2scnc23)nc1OC1COC1 Degrader C18H14F3N5O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-076VPB WO2024125551-A1_3 . Cn1c2cc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)ccc2c2ncccc21 Degrader C21H18F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-S9P3I4 WO2024125551-A1_30 . FC(F)(F)c1cnc(NCc2ccc3c(c2)sc2cccnc23)nc1OC1COC1 Degrader C20H15F3N4O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-A1IHRQ WO2024125551-A1_31 . FC(F)(F)c1cnc(NCc2ccc3c(ccc4cccnc43)c2)nc1OC1COC1 Degrader C22H17F3N4O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-VHSVFW WO2024125551-A1_32 . FC(F)(F)c1cnc(NCc2cc3ccc4cccnc4c3s2)nc1OC1COC1 Degrader C20H15F3N4O2S CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-0BRIGF WO2024125551-A1_33 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CN)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C22H23F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-KOHFI1 WO2024125551-A1_34 . C[C@@H](O)[C@@H](C)Nc1nc(NCc2ccc3c(c2)[nH]c2c(CN)ccnc23)ncc1C(F)(F)F Degrader C22H24F3N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-F8NU9I WO2024125551-A1_35 . COc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)ccc12 Degrader C21H18F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-G5QQ80 WO2024125551-A1_36 . FCc1cnc(NCc2ccc3c(c2)nn2cccnc32)nc1OC1COC1 Degrader C19H17FN6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-KZ6DDP WO2024125551-A1_37 . OCc1ccn2nc3cc(CNc4ncc(C(F)(F)F)c(OC5COC5)n4)ccc3c2n1 Degrader C20H17F3N6O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-KYVOP6 WO2024125551-A1_38 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)nn2ccc(CO)nc32)ncc1C(F)(F)F)C(N)=O Degrader C21H21F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-J7A3HY WO2024125551-A1_39 . OCc1ccnc2c3ccc(CNc4ncc(C(F)(F)F)c(OC5COC5)n4)cc3nn12 Degrader C20H17F3N6O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-AP272H WO2024125551-A1_4 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2cccnc23)ncc1C(F)(F)F)C(N)=O Degrader C21H20F3N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-7LAIPP WO2024125551-A1_40 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)nn2c(CO)ccnc32)ncc1C(F)(F)F)C(N)=O Degrader C21H21F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-9M1K4K WO2024125551-A1_41 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CN(C)C)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C24H27F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-718IXQ WO2024125551-A1_42 . NCc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H](C(N)=O)C4CC4)n3)ccc12 Degrader C23H23F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-98XZ5Z WO2024125551-A1_43 . [Fe]#Cc1cnc(NCc2ccc3c(c2)[nH]c2ccncc23)nc1OC1COC1 Degrader C20H16FeN5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-WLF6XK WO2024125551-A1_44 . FC(F)(F)c1cnc(NCc2ccc3c(c2)[nH]c2cnccc23)nc1OC1COC1 Degrader C20H16F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-PZR0Q1 WO2024125551-A1_45 . FC(F)(F)c1cnc(NCc2ccc3c(c2)[nH]c2ncccc23)nc1OC1COC1 Degrader C20H16F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-2BFQ66 WO2024125551-A1_46 . C[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C21H20F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-EGQ6NF WO2024125551-A1_47 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CNC(C)=O)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C24H25F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-HYF0AU WO2024125551-A1_48 . CC(C)[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CN)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C23H25F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-LLR8TT WO2024125551-A1_49 . FC(F)(F)c1cnc(NCc2ccc3c(c2)nn2ccncc32)nc1OC1COC1 Degrader C19H15F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-0MZN2Z WO2024125551-A1_5 . C[C@@H](O)[C@@H](CO)Nc1nc(NCc2ccc3c(c2)[nH]c2cccnc23)ncc1C(F)(F)F Degrader C21H21F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-6Q4SOY WO2024125551-A1_50 . CC(C)[C@@H](Nc1nc(NCc2ccc3c(c2)nn2c(CO)ccnc32)ncc1C(F)(F)F)C(N)=O Degrader C22H23F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-GO6PQ8 WO2024125551-A1_51 . FC(F)(F)c1cnc(NCc2ccc3c(c2)nc2cccnn23)nc1OC1COC1 Degrader C19H15F3N6O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-TC7GKD 3-[3-(4-Amino-3-ethylphenyl)-2-chlorophenyl]piperidine-2,6-dione SCHEMBL29348336 CCc1cc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)ccc1N Degrader C19H19ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XKN0P6 SCHEMBL29348337 3-[3-[4-[(2-Aminoimidazol-1-yl)methyl]phenyl]-2-chlorophenyl]piperidine-2,6-dione\; SCHEMBL29348337 Nc1nccn1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C21H19ClN4O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-Q2WKD0 SCHEMBL29348338 3-[2-Chloro-3-[4-(pyridin-2-ylmethoxy)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348338 O=C1CCC(c2cccc(-c3ccc(OCc4ccccn4)cc3)c2Cl)C(=O)N1 Degrader C23H19ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-WPESK7 WO2024151547-A1_104 3-[2-Chloro-3-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]phenyl]piperidine-2,6-dione CN1CCN(CCOc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)CC1 Degrader C24H28ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-X79BVU 3-[3-(4-Amino-3-chlorophenyl)-2-chlorophenyl]piperidine-2,6-dione SCHEMBL29348340 Nc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1Cl Degrader C17H14Cl2N2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-4IRQ9Z WO2024151547-A1_106 3-[2-Chloro-3-[4-(2-oxo-1,3-oxazolidin-4-yl)phenyl]phenyl]piperidine-2,6-dione O=C1CCC(c2cccc(-c3ccc(C4COC(=O)N4)cc3)c2Cl)C(=O)N1 Degrader C20H17ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-KWJ53G SCHEMBL29348342 3-[2-Chloro-3-[3-fluoro-4-(2-oxo-1,3-oxazolidin-4-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348342 O=C1CCC(c2cccc(-c3ccc(C4COC(=O)N4)c(F)c3)c2Cl)C(=O)N1 Degrader C20H16ClFN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-8ZF344 WO2024151547-A1_108 3-[2-Chloro-3-[3-(difluoromethoxy)-4-methoxyphenyl]phenyl]piperidine-2,6-dione COc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1OC(F)F Degrader C19H16ClF2NO4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-5VEHZN 3-[2-Chloro-3-[4-(oxolan-3-yloxy)phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348344 O=C1CCC(c2cccc(-c3ccc(OC4CCOC4)cc3)c2Cl)C(=O)N1 Degrader C21H20ClNO4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-31J2Y1 WO2024151547-A1_110 3-[3-[4-[(3-Amino-1,2,4-triazol-1-yl)methyl]phenyl]-2-chlorophenyl]piperidine-2,6-dione Nc1ncn(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C20H18ClN5O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-V5FBAA SCHEMBL29348346 3-[2-Chloro-3-[4-[(2-methylimidazol-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348346 Cc1nccn1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C22H20ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-IGS6PB 5-[2-Chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]-2-hydroxybenzonitrile SCHEMBL29348347 N#Cc1cc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)ccc1O Degrader C18H13ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-FA0PJM WO2024151547-A1_113 . Nc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1OC(F)F Degrader C18H15ClF2N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-269B01 3-[2-Chloro-3-[4-(ethylamino)phenyl]phenyl]piperidine-2,6-dione 0 CCNc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C19H19ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-A1LTXK SCHEMBL29348349 3-[2-Chloro-3-[3-methyl-4-(methylamino)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348349 CNc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1C Degrader C19H19ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-WPGKW1 3-[2-Chloro-3-[4-(3-hydroxypropoxy)phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348350 O=C1CCC(c2cccc(-c3ccc(OCCCO)cc3)c2Cl)C(=O)N1 Degrader C20H20ClNO4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-01VBMP WO2024151547-A1_118 3-[3-[4-[(5-Aminopyrazol-1-yl)methyl]phenyl]-2-chlorophenyl]piperidine-2,6-dione Nc1ccnn1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C21H19ClN4O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-JUTH8R SCHEMBL29348351 3-[2-Chloro-3-[4-(oxolan-2-ylmethoxy)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348351 O=C1CCC(c2cccc(-c3ccc(OCC4CCCO4)cc3)c2Cl)C(=O)N1 Degrader C22H22ClNO4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XICZ2G SCHEMBL29348352 3-[2-Chloro-3-[4-(pyrazol-1-ylmethyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348352 O=C1CCC(c2cccc(-c3ccc(Cn4cccn4)cc3)c2Cl)C(=O)N1 Degrader C21H18ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XTQWAV SCHEMBL29348353 3-[2-Chloro-3-[4-[2-(3-oxopiperazin-1-yl)ethoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348353 O=C1CN(CCOc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)CCN1 Degrader C23H24ClN3O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-2JV6WG SCHEMBL29348354 3-[2-Chloro-3-[4-(2-morpholin-4-ylethyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348354 O=C1CCC(c2cccc(-c3ccc(CCN4CCOCC4)cc3)c2Cl)C(=O)N1 Degrader C23H25ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-M2ZOCN SCHEMBL29348355 3-[2-Chloro-3-[4-(pyridin-3-ylmethoxy)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348355 O=C1CCC(c2cccc(-c3ccc(OCc4cccnc4)cc3)c2Cl)C(=O)N1 Degrader C23H19ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-W7JA1U SCHEMBL29348356 3-[2-Chloro-3-[4-(pyridin-4-ylmethoxy)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348356 O=C1CCC(c2cccc(-c3ccc(OCc4ccncc4)cc3)c2Cl)C(=O)N1 Degrader C23H19ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-SIEWW6 SCHEMBL29348357 3-[2-Chloro-3-[4-(difluoromethyl)-3-methoxyphenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348357 COc1cc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)ccc1C(F)F Degrader C19H16ClF2NO3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-YQM4WT 3-[2-Chloro-3-[4-(3-methoxypropoxy)phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348358 COCCCOc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C21H22ClNO4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-E0TAHA SCHEMBL29348359 3-[2-Chloro-3-[4-[(3,5-dimethylpyrazol-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348359 Cc1cc(C)n(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C23H22ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-8Z3XVU N-[4-[2-chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]phenyl]acetamide 0 CC(=O)Nc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C19H17ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-Z4IOEZ 3-[2-Chloro-3-[4-(propan-2-ylamino)phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348361 CC(C)Nc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C20H21ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-V3U1EB 3-[3-(4-Aminophenyl)-2-chlorophenyl]piperidine-2,6-dione SCHEMBL29348362 Nc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C17H15ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-VGLYJ1 3-[3-(4-Amino-3-methylphenyl)-2-chlorophenyl]piperidine-2,6-dione SCHEMBL29348363 Cc1cc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)ccc1N Degrader C18H17ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-AD1Y1A 3-[2-Chloro-3-(3-methoxy-4-methylphenyl)phenyl]piperidine-2,6-dione SCHEMBL29348364 COc1cc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)ccc1C Degrader C19H18ClNO3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-OROE4U 2-Amino-4-[2-chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]benzonitrile SCHEMBL29348365 N#Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1N Degrader C18H14ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-QLB2VI 3-[2-Chloro-3-[4-(methylamino)phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348366 CNc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C18H17ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-2F58MH SCHEMBL29348367 3-[2-Chloro-3-[4-[2-(dimethylamino)ethoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348367 CN(C)CCOc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C21H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-6ZX0HP SCHEMBL29348368 3-[2-Chloro-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348368 O=C1CCC(c2cccc(-c3ccc(OCCN4CCCC4)cc3)c2Cl)C(=O)N1 Degrader C23H25ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-7NYDV8 SCHEMBL29348369 3-[2-Chloro-3-[4-(difluoromethoxy)-2-methoxyphenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348369 COc1cc(OC(F)F)ccc1-c1cccc(C2CCC(=O)NC2=O)c1Cl Degrader C19H16ClF2NO4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-2XEQA4 WO2024151547-A1_138 . Nc1cc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)ccc1Cl Degrader C17H14Cl2N2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-QKEZ7M 5-[2-Chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]-2-methoxybenzonitrile SCHEMBL29348371 COc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1C#N Degrader C19H15ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-ZON86M SCHEMBL29348372 3-[2-Chloro-3-[4-(imidazol-1-ylmethyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348372 O=C1CCC(c2cccc(-c3ccc(Cn4ccnc4)cc3)c2Cl)C(=O)N1 Degrader C21H18ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-QPFGTA SCHEMBL29348373 3-[2-Chloro-3-[4-(oxolan-3-ylmethoxy)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348373 O=C1CCC(c2cccc(-c3ccc(OCC4CCOC4)cc3)c2Cl)C(=O)N1 Degrader C22H22ClNO4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-9UPXVR 4-[2-Chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]benzonitrile SCHEMBL29348374 N#Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C18H13ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-8VCLAL SCHEMBL29348375 3-[2-Chloro-6-fluoro-3-[4-[(2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348375 O=C1CCC(c2c(F)ccc(-c3ccc(Cn4ccccc4=O)cc3)c2Cl)C(=O)N1 Degrader C23H18ClFN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-FP4C29 SCHEMBL29348717 3-[2-Chloro-6-fluoro-3-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348717 Cn1ccc(COc2ccc(-c3ccc(F)c(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H19ClFN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-4MKTZZ SCHEMBL29348377 3-[6-Chloro-2-fluoro-3-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348377 Cn1ccc(COc2ccc(-c3ccc(Cl)c(C4CCC(=O)NC4=O)c3F)cc2)n1 Degrader C22H19ClFN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-W7UBC2 WO2024151547-A1_146 3-[2,6-Dichloro-3-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione Cn1ccc(COc2ccc(-c3ccc(Cl)c(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H19Cl2N3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-3KYM53 SCHEMBL29348379 3-[2,6-Difluoro-3-[4-[(2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348379 O=C1CCC(c2c(F)ccc(-c3ccc(Cn4ccccc4=O)cc3)c2F)C(=O)N1 Degrader C23H18F2N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-2G8PPH SCHEMBL29348380 3-[2,6-Difluoro-3-(4-methoxy-3-methylphenyl)phenyl]piperidine-2,6-dione\; SCHEMBL29348380 COc1ccc(-c2ccc(F)c(C3CCC(=O)NC3=O)c2F)cc1C Degrader C19H17F2NO3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-10P92T SCHEMBL29348381 3-[2-Fluoro-3-[4-[(2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348381 O=C1CCC(c2cccc(-c3ccc(Cn4ccccc4=O)cc3)c2F)C(=O)N1 Degrader C23H19FN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-2PSM3H WO2024151547-A1_150 3-[2-Fluoro-3-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione Cn1ccc(COc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3F)cc2)n1 Degrader C22H20FN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XR7OAJ SCHEMBL29348741 3-[3-[4-[(1-Methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348741 Cn1ccc(COc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3)cc2)n1 Degrader C22H21N3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-SBL8W0 SCHEMBL29348384 3-[2-Chloro-5-[2-methyl-4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348384 Cc1cc(OCc2ccn(C)n2)ccc1-c1ccc(Cl)c(C2CCC(=O)NC2=O)c1 Degrader C23H22ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-B5LPI2 SCHEMBL29348288 3-[2-Chloro-5-[2-chloro-4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348288 Cn1ccc(COc2ccc(-c3ccc(Cl)c(C4CCC(=O)NC4=O)c3)c(Cl)c2)n1 Degrader C22H19Cl2N3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-2RLV7X SCHEMBL29348386 3-[2-Chloro-3-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348386 Cn1ccc(COc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-I3Z6W9 SCHEMBL29348387 3-[2-Chloro-3-[3-methyl-4-(2-morpholin-4-ylethoxy)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348387 Cc1cc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)ccc1OCCN1CCOCC1 Degrader C24H27ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-YYMGI5 SCHEMBL29348388 3-[2-Chloro-3-[4-[(2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348388 O=C1CCC(c2cccc(-c3ccc(Cn4ccccc4=O)cc3)c2Cl)C(=O)N1 Degrader C23H19ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-87R9T4 SCHEMBL29348389 4-Chloro-3-(2,6-dioxopiperidin-3-yl)-5-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]benzonitrile\; SCHEMBL29348389 Cn1ccc(COc2ccc(-c3cc(C#N)cc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C23H19ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-8JDG49 SCHEMBL29348390 3-[2-Chloro-3-[4-[(2-methyl-5-oxopyrazol-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348390 Cn1ccc(=O)n1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C22H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-UBE1ZN SCHEMBL29348391 3-[2-Chloro-3-[4-(pyrazin-2-ylmethyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348391 O=C1CCC(c2cccc(-c3ccc(Cc4cnccn4)cc3)c2Cl)C(=O)N1 Degrader C22H18ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-QDU027 SCHEMBL29348392 3-[2-Chloro-3-[4-[(1-methylpyrazol-3-yl)oxymethyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348392 Cn1ccc(OCc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XQ90XZ SCHEMBL29348285 3-[2-Chloro-3-[4-(2-oxopiperidin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348285 O=C1CCC(c2cccc(-c3ccc(N4CCCCC4=O)cc3)c2Cl)C(=O)N1 Degrader C22H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-FLGPNR WO2024151547-A1_162 . C=C1CCC(c2cccc(-c3ccc(N4CCCC4=O)cc3)c2Cl)C(=O)N1 Degrader C22H21ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-YLX70H SCHEMBL29348394 3-[2-Chloro-3-[4-(2-oxoazetidin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348394 O=C1CCC(c2cccc(-c3ccc(N4CCC4=O)cc3)c2Cl)C(=O)N1 Degrader C20H17ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-UUQVSA SCHEMBL29348395 3-[2-Chloro-3-[4-(1-methylpyrazol-3-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348395 Cn1ccc(-c2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C21H18ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-9WSLLP SCHEMBL29348396 3-[2-Chloro-3-[4-(1-pyridin-2-yloxyethyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348396 CC(Oc1ccccn1)c1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C24H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-ABLDMU WO2024151547-A1_166 3-[2-Chloro-3-[4-[4-[(2-oxopyridin-1-yl)methyl]piperidin-1-yl]phenyl]phenyl]piperidine-2,6-dione O=C1CCC(c2cccc(-c3ccc(N4CCC(Cn5ccccc5=O)CC4)cc3)c2Cl)C(=O)N1 Degrader C28H28ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-MFFB8F SCHEMBL29348398 3-[2-chloro-3-[4-(1H-imidazol-5-ylmethoxy)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348398 O=C1CCC(c2cccc(-c3ccc(OCc4c[nH]cn4)cc3)c2Cl)C(=O)N1 Degrader C21H18ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-S7MUS1 SCHEMBL29348399 3-[2-Chloro-3-[4-[(2-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348399 O=C1CCC(c2cccc(-c3ccc(CN4CCCCC4=O)cc3)c2Cl)C(=O)N1 Degrader C23H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-EW35SQ SCHEMBL29348400 3-[2-Chloro-3-[4-(pyridin-2-ylmethyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348400 O=C1CCC(c2cccc(-c3ccc(Cc4ccccn4)cc3)c2Cl)C(=O)N1 Degrader C23H19ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-NDK54A SCHEMBL29348401 3-[2-Chloro-3-[4-[(4-fluoro-2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348401 O=C1CCC(c2cccc(-c3ccc(Cn4ccc(F)cc4=O)cc3)c2Cl)C(=O)N1 Degrader C23H18ClFN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-5Z0LCB SCHEMBL29348402 3-[2-Chloro-3-[4-[[2-oxo-4-(trifluoromethyl)pyridin-1-yl]methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348402 O=C1CCC(c2cccc(-c3ccc(Cn4ccc(C(F)(F)F)cc4=O)cc3)c2Cl)C(=O)N1 Degrader C24H18ClF3N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-1FJ2W0 SCHEMBL29348403 3-[2-Chloro-4-ethynyl-3-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348403 C#Cc1ccc(C2CCC(=O)NC2=O)c(Cl)c1-c1ccc(OCc2ccn(C)n2)cc1 Degrader C24H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-D11O8J SCHEMBL29348404 3-[2-Chloro-3-[4-[1-(1-methylpyrazol-3-yl)ethoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348404 CC(Oc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1)c1ccn(C)n1 Degrader C23H22ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-AL0HP8 WO2024151547-A1_174 3-[2-Chloro-3-[4-[1-(2-oxopyridin-1-yl)ethyl]phenyl]phenyl]piperidine-2,6-dione CC(c1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1)n1ccccc1=O Degrader C24H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-IKXE49 SCHEMBL29348406 3-[2-Chloro-3-[4-[(4-methoxy-2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348406 COc1ccn(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)c(=O)c1 Degrader C24H21ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-SWU143 EX-A12317 3-[2-Chloro-3-[4-[(1-methylpyrazol-3-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; VAV1 degrader-2; SCHEMBL29348744; EX-A12317; 3050683-29-6 Cn1ccc(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H20ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-H0KITJ SCHEMBL29348408 3-[2-Chloro-3-[2-chloro-4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348408 Cn1ccc(COc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)c(Cl)c2)n1 Degrader C22H19Cl2N3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XEKPLS SCHEMBL29348409 3-[2-Chloro-3-[4-[3-(2-oxopyridin-1-yl)propyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348409 O=C1CCC(c2cccc(-c3ccc(CCCn4ccccc4=O)cc3)c2Cl)C(=O)N1 Degrader C25H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-45ATSA SCHEMBL29348410 3-Chloro-4-(2,6-dioxopiperidin-3-yl)-2-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]benzonitrile\; SCHEMBL29348410 Cn1ccc(COc2ccc(-c3c(C#N)ccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C23H19ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-U0K7E6 SCHEMBL29348411 3-[2-Chloro-3-[4-[(1-methylpyrazol-3-yl)methylamino]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348411 Cn1ccc(CNc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H21ClN4O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-TGADST SCHEMBL29348412 3-[2-Chloro-3-[4-(pyrrolidine-1-carbonyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348412 O=C1CCC(c2cccc(-c3ccc(C(=O)N4CCCC4)cc3)c2Cl)C(=O)N1 Degrader C22H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-1IK50G WO2024151547-A1_182 3-[2-Chloro-3-[4-[2-(2-oxopyridin-1-yl)ethyl]phenyl]phenyl]piperidine-2,6-dione O=C1CCC(c2cccc(-c3ccc(CCn4ccccc4=O)cc3)c2Cl)C(=O)N1 Degrader C24H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-46UPO9 SCHEMBL29348414 3-[2-Chloro-3-[4-[(1-methylimidazol-4-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348414 Cn1cnc(COc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)c1 Degrader C22H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-O1ZWIH SCHEMBL29348415 3-[2-Chloro-3-[4-[(2-methyl-6-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348415 Cc1cccc(=O)n1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C24H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-ZRLX8D VAV1 degrader-3 VAV1 degrader-3; 3050683-38-7; SCHEMBL29348198; EX-A11887 O=C1CCC(c2cccc(-c3ccc(-n4ccccc4=O)cc3)c2Cl)C(=O)N1 Degrader C22H17ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-O2IIDZ SCHEMBL29348416 3-[2-Chloro-3-[4-[(3-methylimidazol-4-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348416 Cn1cncc1COc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C22H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-N53VKI SCHEMBL29348417 3-[2-Chloro-3-[4-[(3-methyl-2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348417 Cc1cccn(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)c1=O Degrader C24H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-V6UYRJ SCHEMBL29348418 3-[2-Chloro-3-[4-[(5-methyl-2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348418 Cc1ccc(=O)n(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)c1 Degrader C24H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-RW54GS SCHEMBL29348419 3-[2-Chloro-3-[4-[(4-methyl-2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348419 Cc1ccn(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)c(=O)c1 Degrader C24H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-WHO8ZC SCHEMBL29348420 3-[2-Chloro-3-[3-(oxolan-3-yloxymethyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348420 O=C1CCC(c2cccc(-c3cccc(COC4CCOC4)c3)c2Cl)C(=O)N1 Degrader C22H22ClNO4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-N39DCP WO2024151547-A1_191 3-[3-[4-[(1-Methylpyrazol-3-yl)methoxy]phenyl]-2-(trifluoromethyl)phenyl]piperidine-2,6-dione Cn1ccc(COc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3C(F)(F)F)cc2)n1 Degrader C23H20F3N3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-NI9WKI SCHEMBL29348421 3-[2-Methyl-3-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348421 Cc1c(-c2ccc(OCc3ccn(C)n3)cc2)cccc1C1CCC(=O)NC1=O Degrader C23H23N3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-1X0452 SCHEMBL29348422 3-[2-Chloro-3-[4-[(1-methylpyrazol-4-yl)methylamino]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348422 Cn1cc(CNc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)cn1 Degrader C22H21ClN4O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-RQC10T WO2024151547-A1_194 3-[2-Chloro-3-[4-[2-(1-methylpyrazol-3-yl)ethyl]phenyl]phenyl]piperidine-2,6-dione Cn1ccc(CCc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C23H22ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-ICPF0R 3-[3-[4-(Azetidin-1-yl)phenyl]-2-chlorophenyl]piperidine-2,6-dione SCHEMBL29348424 O=C1CCC(c2cccc(-c3ccc(N4CCC4)cc3)c2Cl)C(=O)N1 Degrader C20H19ClN2O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-51TXQW SCHEMBL29348425 3-[2-Chloro-3-[4-[[(1-methylpyrazol-3-yl)amino]methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348425 Cn1ccc(NCc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H21ClN4O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-0G128E SCHEMBL29348426 3-[2-Chloro-3-[4-[2-(2-oxopiperidin-1-yl)propan-2-yl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348426 CC(C)(c1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1)N1CCCCC1=O Degrader C25H27ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-2K3I9B 3-[2-Chloro-3-[4-(oxetan-3-yl)phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348427 O=C1CCC(c2cccc(-c3ccc(C4COC4)cc3)c2Cl)C(=O)N1 Degrader C20H18ClNO3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-FCHVBI SCHEMBL29348428 3-[2-Chloro-3-[3-methyl-4-(2-oxopyridin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348428 Cc1cc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)ccc1-n1ccccc1=O Degrader C23H19ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-9G4WV3 SCHEMBL29348757 3-[2-Chloro-3-[4-(2-methyl-6-oxopiperidin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348757 CC1CCCC(=O)N1c1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C23H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-T294DW SCHEMBL29348758 (3R)-3-[2-chloro-3-[4-[(2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348758 O=C1CC[C@H](c2cccc(-c3ccc(Cn4ccccc4=O)cc3)c2Cl)C(=O)N1 Degrader C23H19ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-T4YIP0 SCHEMBL29348430 (3S)-3-[2-chloro-3-[4-[(2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348430 O=C1CC[C@@H](c2cccc(-c3ccc(Cn4ccccc4=O)cc3)c2Cl)C(=O)N1 Degrader C23H19ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-EGFWDW SCHEMBL29348431 3-[2-chloro-3-[4-(1H-pyrazol-5-ylmethoxy)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348431 O=C1CCC(c2cccc(-c3ccc(OCc4cc[nH]n4)cc3)c2Cl)C(=O)N1 Degrader C21H18ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-X0QS9V SCHEMBL29348432 3-[2-Chloro-3-[4-(2-oxo-1,3-oxazinan-3-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348432 O=C1CCC(c2cccc(-c3ccc(N4CCCOC4=O)cc3)c2Cl)C(=O)N1 Degrader C21H19ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-3WSVLW SCHEMBL29348433 1-[4-[2-Chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348433 O=C1CCC(c2cccc(-c3ccc(N4C(=O)CCCC4=O)cc3)c2Cl)C(=O)N1 Degrader C22H19ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-6OHIXI SCHEMBL29348434 3-[2-Chloro-3-[4-[(2-oxopyrrolidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348434 O=C1CCC(c2cccc(-c3ccc(CN4CCCC4=O)cc3)c2Cl)C(=O)N1 Degrader C22H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-SQWILS SCHEMBL29348435 N-[4-[2-chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]phenyl]-1-methylpyrazole-3-carboxamide\; SCHEMBL29348435 Cn1ccc(C(=O)Nc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H19ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-406FI7 SCHEMBL29348436 3-[2-Chloro-3-[4-(pyrimidin-2-ylmethyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348436 O=C1CCC(c2cccc(-c3ccc(Cc4ncccn4)cc3)c2Cl)C(=O)N1 Degrader C22H18ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-DN0RDN SCHEMBL29348437 (3S)-3-[2-chloro-3-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348437 Cn1ccc(COc2ccc(-c3cccc([C@@H]4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-P4G24A EX-A9879 2,6-Piperidinedione, 3-[2-chloro-4 inverted exclamation marka-(2-oxo-1(2H)-pyridinyl)[1,1 inverted exclamation marka-biphenyl]-3-yl]-, (3R)-\; SCHEMBL29348202; EX-A9879; 2,6-Piperidinedione, 3-[2-chloro-4 inverted exclamation marka-(2-oxo-1(2H)-pyridinyl)[1,1 inverted exclamation marka-biphenyl]-3-yl]-, (3R)-; 3050683-63-8 O=C1CC[C@H](c2cccc(-c3ccc(-n4ccccc4=O)cc3)c2Cl)C(=O)N1 Degrader C22H17ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-DFM6V7 SCHEMBL29348199 (3S)-3-[2-chloro-3-[4-(2-oxopyridin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348199 O=C1CC[C@@H](c2cccc(-c3ccc(-n4ccccc4=O)cc3)c2Cl)C(=O)N1 Degrader C22H17ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-F3VTEJ SCHEMBL29348438 3-[2-Chloro-3-[4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348438 O=C1CCC(c2cccc(-c3ccc(N4CCOC4=O)cc3)c2Cl)C(=O)N1 Degrader C20H17ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-Q3MI8W SCHEMBL29348439 (3R)-3-[2-chloro-3-[4-[(1-methylpyrazol-3-yl)methoxy]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348439 Cn1ccc(COc2ccc(-c3cccc([C@H]4CCC(=O)NC4=O)c3Cl)cc2)n1 Degrader C22H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-W4IQU7 SCHEMBL29348440 3-[2-Chloro-3-[4-(2-methyl-6-oxopyridin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348440 Cc1cccc(=O)n1-c1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C23H19ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-QWW6UX 3-[2-Chloro-3-[4-(pyridin-2-ylamino)phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348441 O=C1CCC(c2cccc(-c3ccc(Nc4ccccn4)cc3)c2Cl)C(=O)N1 Degrader C22H18ClN3O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-MRK25D SCHEMBL29348442 3-[2-chloro-3-[4-[(4S)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348442 C[C@H]1COC(=O)N1c1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C21H19ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-0VQUMR SCHEMBL29348443 3-[2-chloro-3-[4-[(4R)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348443 C[C@@H]1COC(=O)N1c1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C21H19ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-M8T1WW SCHEMBL29348444 3-[2-Chloro-3-[4-(3-fluoro-2-oxopyridin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348444 O=C1CCC(c2cccc(-c3ccc(-n4cccc(F)c4=O)cc3)c2Cl)C(=O)N1 Degrader C22H16ClFN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-V3LPEM SCHEMBL29348445 3-[2-Chloro-3-[4-[(2-oxo-1,3-oxazolidin-3-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348445 O=C1CCC(c2cccc(-c3ccc(CN4CCOC4=O)cc3)c2Cl)C(=O)N1 Degrader C21H19ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-FX86IC WO2024151547-A1_220 3-[2-Chloro-3-[4-(1,1-dioxothiazinan-2-yl)phenyl]phenyl]piperidine-2,6-dione O=C1CCC(c2cccc(-c3ccc(N4CCCCS4(=O)=O)cc3)c2Cl)C(=O)N1 Degrader C21H21ClN2O4S VAV1 P15498 CRBN WO-2024151547-A1 TPD-952ENZ SCHEMBL29348447 3-[2-Chloro-3-[4-(3,3-difluoropyrrolidine-1-carbonyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348447 O=C1CCC(c2cccc(-c3ccc(C(=O)N4CCC(F)(F)C4)cc3)c2Cl)C(=O)N1 Degrader C22H19ClF2N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-YRELFH WO2024151547-A1_222 3-[2-Chloro-3-[4-(pyrrole-1-carbonyl)phenyl]phenyl]piperidine-2,6-dione O=C1CCC(c2cccc(-c3ccc(C(=O)n4cccc4)cc3)c2Cl)C(=O)N1 Degrader C22H17ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XR9PIK SCHEMBL29348783 3-[2-Chloro-3-[4-(piperidine-1-carbonyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348783 O=C1CCC(c2cccc(-c3ccc(C(=O)N4CCCCC4)cc3)c2Cl)C(=O)N1 Degrader C23H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-11A396 SCHEMBL29348450 4-[2-chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]-N-(1,2-oxazol-5-yl)benzamide\; SCHEMBL29348450 O=C1CCC(c2cccc(-c3ccc(C(=O)Nc4ccno4)cc3)c2Cl)C(=O)N1 Degrader C21H16ClN3O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-8NMLM5 SCHEMBL29348451 3-[2-Chloro-3-[4-(1-methyl-2-oxopyridin-3-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348451 Cn1cccc(-c2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)c1=O Degrader C23H19ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-4PB725 SCHEMBL29348452 3-[2-Chloro-3-[4-[2-oxo-3-(trifluoromethyl)pyridin-1-yl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348452 O=C1CCC(c2cccc(-c3ccc(-n4cccc(C(F)(F)F)c4=O)cc3)c2Cl)C(=O)N1 Degrader C23H16ClF3N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-7DVA58 SCHEMBL29348453 N-[4-[2-chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]phenyl]oxolane-3-carboxamide\; SCHEMBL29348453 O=C1CCC(c2cccc(-c3ccc(NC(=O)C4CCOC4)cc3)c2Cl)C(=O)N1 Degrader C22H21ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-OHWBY8 SCHEMBL29348454 N-[4-[2-chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]phenyl]-1,2-oxazole-5-carboxamide\; SCHEMBL29348454 O=C1CCC(c2cccc(-c3ccc(NC(=O)c4ccno4)cc3)c2Cl)C(=O)N1 Degrader C21H16ClN3O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-SOJJP8 SCHEMBL29348455 N-[4-[2-chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]phenyl]-1,2-oxazole-3-carboxamide\; SCHEMBL29348455 O=C1CCC(c2cccc(-c3ccc(NC(=O)c4ccon4)cc3)c2Cl)C(=O)N1 Degrader C21H16ClN3O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-5GW37G WO2024151547-A1_230 . O=C1CCC(c2cccc(-c3ccc(NNc4ccon4)cc3)c2Cl)C(=O)N1 Degrader C20H17ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-NVKE5G SCHEMBL29348457 3-[2-Chloro-3-[4-[2-(2-oxopyridin-1-yl)propan-2-yl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348457 CC(C)(c1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1)n1ccccc1=O Degrader C25H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-D5O2AM SCHEMBL29348794 3-[2-Chloro-3-[4-(5-oxo-4-azaspiro[2.5]octan-4-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348794 O=C1CCC(c2cccc(-c3ccc(N4C(=O)CCCC45CC5)cc3)c2Cl)C(=O)N1 Degrader C24H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-1VHJ9G 3-[2-Chloro-3-[4-(oxetan-3-ylmethyl)phenyl]phenyl]piperidine-2,6-dione 0 O=C1CCC(c2cccc(-c3ccc(CC4COC4)cc3)c2Cl)C(=O)N1 Degrader C21H20ClNO3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-D1HLV7 3-[2-Fluoro-3-[4-(2-oxopyridin-1-yl)phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348460 O=C1CCC(c2cccc(-c3ccc(-n4ccccc4=O)cc3)c2F)C(=O)N1 Degrader C22H17FN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-KE3CSE SCHEMBL29348461 3-[2-Chloro-3-[4-(2-oxo-2-pyrrolidin-1-ylethyl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348461 O=C1CCC(c2cccc(-c3ccc(CC(=O)N4CCCC4)cc3)c2Cl)C(=O)N1 Degrader C23H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-E7N6RS WO2024151547-A1_236 3-[2-Chloro-3-[4-[2-oxo-4-(trifluoromethyl)pyridin-1-yl]phenyl]phenyl]piperidine-2,6-dione O=C1CCC(c2cccc(-c3ccc(-n4ccc(C(F)(F)F)cc4=O)cc3)c2Cl)C(=O)N1 Degrader C23H16ClF3N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-LOQU90 SCHEMBL29348463 3-[2-Chloro-3-[4-[2-oxo-5-(trifluoromethyl)pyridin-1-yl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348463 O=C1CCC(c2cccc(-c3ccc(-n4cc(C(F)(F)F)ccc4=O)cc3)c2Cl)C(=O)N1 Degrader C23H16ClF3N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-C63RQE SCHEMBL29348812 3-[2-Chloro-3-[4-[2-(difluoromethyl)-6-oxopyridin-1-yl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348812 O=C1CCC(c2cccc(-c3ccc(-n4c(C(F)F)cccc4=O)cc3)c2Cl)C(=O)N1 Degrader C23H17ClF2N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-WRMTG2 3-[3-[4-[(2-Oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348465 O=C1CCC(c2cccc(-c3ccc(Cn4ccccc4=O)cc3)c2)C(=O)N1 Degrader C23H20N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-DQPBZ6 3-[2-Methyl-3-[4-(2-oxopyridin-1-yl)phenyl]phenyl]piperidine-2,6-dione SCHEMBL29348466 Cc1c(-c2ccc(-n3ccccc3=O)cc2)cccc1C1CCC(=O)NC1=O Degrader C23H20N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-MBD0MW SCHEMBL29348467 3-[2-Chloro-3-[4-[1-(2-oxopyridin-1-yl)cyclopropyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348467 O=C1CCC(c2cccc(-c3ccc(C4(n5ccccc5=O)CC4)cc3)c2Cl)C(=O)N1 Degrader C25H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-E1YGWU SCHEMBL29348802 3-[2-Chloro-3-[4-(2-fluoro-6-oxopyridin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348802 O=C1CCC(c2cccc(-c3ccc(-n4c(F)cccc4=O)cc3)c2Cl)C(=O)N1 Degrader C22H16ClFN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-BL8ZGR WO2024151547-A1_243 3-[2-Methyl-3-[4-[(2-oxopyridin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione Cc1c(-c2ccc(Cn3ccccc3=O)cc2)cccc1C1CCC(=O)NC1=O Degrader C24H22N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-EDPGDS SCHEMBL29348469 3-[2-Chloro-3-[4-[2-oxo-6-(trifluoromethyl)piperidin-1-yl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348469 O=C1CCC(c2cccc(-c3ccc(N4C(=O)CCCC4C(F)(F)F)cc3)c2Cl)C(=O)N1 Degrader C23H20ClF3N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-ST63RA SCHEMBL29348798 3-[2-Chloro-3-[4-(4-fluoro-2-oxopyridin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348798 O=C1CCC(c2cccc(-c3ccc(-n4ccc(F)cc4=O)cc3)c2Cl)C(=O)N1 Degrader C22H16ClFN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-4F47AF SCHEMBL29348471 3-[2-Chloro-3-[4-(5-fluoro-2-oxopyridin-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348471 O=C1CCC(c2cccc(-c3ccc(-n4cc(F)ccc4=O)cc3)c2Cl)C(=O)N1 Degrader C22H16ClFN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-A43OKC SCHEMBL29348472 3-[2-Chloro-3-[4-(3-methyl-2-oxo-1,3-diazinan-1-yl)phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348472 CN1CCCN(c2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C1=O Degrader C22H22ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-HVWC7N SCHEMBL29348473 N-[4-[2-chloro-3-(2,6-dioxopiperidin-3-yl)phenyl]phenyl]pyrrolidine-1-carboxamide\; SCHEMBL29348473 O=C1CCC(c2cccc(-c3ccc(NC(=O)N4CCCC4)cc3)c2Cl)C(=O)N1 Degrader C22H22ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-45P95C SCHEMBL29348474 3-[2-Chloro-3-[6-[2-(1-methylpyrazol-3-yl)ethyl]pyridin-3-yl]phenyl]piperidine-2,6-dione\; SCHEMBL29348474 Cn1ccc(CCc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cn2)n1 Degrader C22H21ClN4O2 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XACW7Y SCHEMBL29348475 3-[2-Chloro-3-[6-[(1-methylpyrazol-3-yl)methoxy]pyridin-3-yl]phenyl]piperidine-2,6-dione\; SCHEMBL29348475 Cn1ccc(COc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cn2)n1 Degrader C21H19ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-V8SG4G SCHEMBL29348476 3-[2-Chloro-3-[4-[(4-oxo-6,7-dihydro-[1,3]oxazolo[4,5-c]pyridin-5-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348476 O=C1CCC(c2cccc(-c3ccc(CN4CCc5ocnc5C4=O)cc3)c2Cl)C(=O)N1 Degrader C24H20ClN3O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-FYK8LG WO2024151547-A1_253 3-[2-Chloro-3-[4-[(5-oxo-6,7-dihydropyrazolo[1,5-a]pyrimidin-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione O=C1CCC(c2cccc(-c3ccc(CN4C(=O)CCn5nccc54)cc3)c2Cl)C(=O)N1 Degrader C24H21ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-DRL11J WO2024151547-A1_254 3-[2-Chloro-3-[4-[(2-methyl-3-oxopyrido[4,3-b][1,4]oxazin-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione CC1Oc2ccncc2N(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C1=O Degrader C26H22ClN3O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-RMQUWF SCHEMBL29348479 3-[2-chloro-3-[4-[(4-methyl-2-oxo-3H-pyrido[2,3-b]pyrazin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348479 CN1CC(=O)N(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)c2cccnc21 Degrader C26H23ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-1RX5P0 SCHEMBL29348480 3-[2-chloro-3-[4-[(1-methyl-3-oxo-2H-pyrido[3,4-b]pyrazin-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348480 CN1CC(=O)N(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)c2cnccc21 Degrader C26H23ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-0H1CZS WO2024151547-A1_257 3-[2-Chloro-3-[4-[(4,5,5-trimethyl-2-oxopiperazin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione CN1CC(=O)N(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)CC1(C)C Degrader C25H28ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XJUJMJ SCHEMBL29348482 3-[2-Chloro-3-[4-[[5-oxo-2-(trifluoromethyl)morpholin-4-yl]methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348482 O=C1CCC(c2cccc(-c3ccc(CN4CC(C(F)(F)F)OCC4=O)cc3)c2Cl)C(=O)N1 Degrader C23H20ClF3N2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-36AEXS SCHEMBL29348483 3-[2-Chloro-3-[4-[(5-methyl-7-oxo-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348483 CN1CC(=O)N(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)CC12COC2 Degrader C25H26ClN3O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-1OBXBB SCHEMBL29348484 3-[2-Chloro-3-[4-[(3-oxo-1,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348484 O=C1CCC(c2cccc(-c3ccc(CN4CC5CCCN5CC4=O)cc3)c2Cl)C(=O)N1 Degrader C25H26ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-Y5HTXR SCHEMBL29348485 3-[2-Chloro-3-[4-[(1-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348485 O=C1CCC(c2cccc(-c3ccc(CN4CCN5CCCC5C4=O)cc3)c2Cl)C(=O)N1 Degrader C25H26ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-RL6MXH SCHEMBL29348486 3-[2-Chloro-3-[4-[[3-oxo-5-(trifluoromethyl)morpholin-4-yl]methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348486 O=C1CCC(c2cccc(-c3ccc(CN4C(=O)COCC4C(F)(F)F)cc3)c2Cl)C(=O)N1 Degrader C23H20ClF3N2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-L73PWR SCHEMBL29348487 3-[2-Chloro-3-[4-[(3,3-dimethyl-5-oxomorpholin-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348487 CC1(C)COCC(=O)N1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C24H25ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-FNXI7E SCHEMBL29348488 3-[2-Chloro-3-[4-[(5-oxo-7-oxa-4-azaspiro[2.5]octan-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348488 O=C1CCC(c2cccc(-c3ccc(CN4C(=O)COCC45CC5)cc3)c2Cl)C(=O)N1 Degrader C24H23ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-Q711XH WO2024151547-A1_265 3-[2-chloro-3-[4-[[(3S)-3-methyl-5-oxomorpholin-4-yl]methyl]phenyl]phenyl]piperidine-2,6-dione C[C@H]1COCC(=O)N1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C23H23ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-Z74HH9 SCHEMBL29348490 3-[2-Chloro-3-[4-[(3,3-difluoro-6-methyl-2-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348490 CC1CCC(F)(F)C(=O)N1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C24H23ClF2N2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-ZH3YUH SCHEMBL29348491 3-[2-Chloro-3-[4-[(2,6-dimethyl-3-oxomorpholin-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348491 CC1CN(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C(=O)C(C)O1 Degrader C24H25ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-7X2V3A WO2024151547-A1_268 3-[2-Chloro-3-[4-[(2,2-dimethyl-5-oxomorpholin-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione CC1(C)CN(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C(=O)CO1 Degrader C24H25ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-RIJ96C SCHEMBL29348493 3-[2-Chloro-3-[4-[(1-fluoro-4-oxo-3-azabicyclo[3.1.1]heptan-3-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348493 O=C1CCC(c2cccc(-c3ccc(CN4CC5(F)CC(C5)C4=O)cc3)c2Cl)C(=O)N1 Degrader C24H22ClFN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XXPL5L SCHEMBL29348494 3-[2-Chloro-3-[4-[(3-fluoro-2-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348494 O=C1CCC(c2cccc(-c3ccc(CN4CCCC(F)C4=O)cc3)c2Cl)C(=O)N1 Degrader C23H22ClFN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-GME5M4 SCHEMBL29348495 3-[2-Chloro-3-[4-[(2-methoxy-6-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348495 COC1CCCC(=O)N1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C24H25ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-5FE30L WO2024151547-A1_272 3-[2-Chloro-3-[4-[(1-methyl-7-oxo-4,5-dihydropyrrolo[2,3-c]pyridin-6-yl)methyl]phenyl]phenyl]piperidine-2,6-dione Cn1ccc2c1C(=O)N(Cc1ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc1)CC2 Degrader C26H24ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-NKF7QI SCHEMBL29348497 3-[2-Chloro-3-[4-[(8-oxo-5,6-dihydroimidazo[1,5-a]pyrazin-7-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348497 O=C1CCC(c2cccc(-c3ccc(CN4CCn5cncc5C4=O)cc3)c2Cl)C(=O)N1 Degrader C24H21ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-WMOOI6 SCHEMBL29348498 3-[2-Chloro-3-[4-[(8-oxo-5,6-dihydroimidazo[1,2-a]pyrazin-7-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348498 O=C1CCC(c2cccc(-c3ccc(CN4CCn5ccnc5C4=O)cc3)c2Cl)C(=O)N1 Degrader C24H21ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-XHLP32 SCHEMBL29348499 3-[2-Chloro-3-[4-[(4-oxo-6,7-dihydropyrazolo[1,5-a]pyrazin-5-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348499 O=C1CCC(c2cccc(-c3ccc(CN4CCn5nccc5C4=O)cc3)c2Cl)C(=O)N1 Degrader C24H21ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-WXOA7A SCHEMBL29348500 3-[2-Chloro-3-[4-[(6-oxo-5,8-dihydroimidazo[1,2-a]pyrazin-7-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348500 O=C1CCC(c2cccc(-c3ccc(CN4Cc5nccn5CC4=O)cc3)c2Cl)C(=O)N1 Degrader C24H21ClN4O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-L6R84J WO2024151547-A1_277 3-[2-Chloro-3-[4-[(4-methyl-2-oxopiperazin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione CN1CCN(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C(=O)C1 Degrader C23H24ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-UB25C2 SCHEMBL29348502 3-[2-Chloro-3-[4-[(2-oxo-7-oxa-1-azaspiro[3.5]nonan-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348502 O=C1CCC(c2cccc(-c3ccc(CN4C(=O)CC45CCOCC5)cc3)c2Cl)C(=O)N1 Degrader C25H25ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-ZLL4BQ WO2024151547-A1_279 3-[2-Chloro-3-[4-[(2-oxo-1-azaspiro[3.3]heptan-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione O=C1CCC(c2cccc(-c3ccc(CN4C(=O)CC45CCC5)cc3)c2Cl)C(=O)N1 Degrader C24H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-ZYGNYE SCHEMBL29348503 3-[2-Chloro-3-[4-[(6-oxo-2-oxa-7-azaspiro[3.5]nonan-7-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348503 O=C1CCC(c2cccc(-c3ccc(CN4CCC5(COC5)CC4=O)cc3)c2Cl)C(=O)N1 Degrader C25H25ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-PNY7YO SCHEMBL29348504 3-[2-Chloro-3-[4-[(6-oxo-2-oxa-7-azaspiro[3.4]octan-7-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348504 O=C1CCC(c2cccc(-c3ccc(CN4CC5(COC5)CC4=O)cc3)c2Cl)C(=O)N1 Degrader C24H23ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-UFS4XZ SCHEMBL29348505 3-[2-Chloro-3-[4-[(3-oxo-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348505 O=C1CCC(c2cccc(-c3ccc(CN4CC5CCCC5C4=O)cc3)c2Cl)C(=O)N1 Degrader C25H25ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-58GN37 SCHEMBL29348506 3-[2-Chloro-3-[4-[(2-oxo-3-azabicyclo[4.1.0]heptan-3-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348506 O=C1CCC(c2cccc(-c3ccc(CN4CCC5CC5C4=O)cc3)c2Cl)C(=O)N1 Degrader C24H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-EXNQ94 SCHEMBL29348507 3-[2-Chloro-3-[4-[(5,5-dimethyl-2-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348507 CC1(C)CCC(=O)N(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C1 Degrader C25H27ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-6OP1Z7 WO2024151547-A1_285 3-[2-Chloro-3-[4-[(4,4-dimethyl-2-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione CC1(C)CCN(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C(=O)C1 Degrader C25H27ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-PR1W4C SCHEMBL29348509 3-[2-Chloro-3-[4-[(4-methyl-2-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348509 CC1CCN(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C(=O)C1 Degrader C24H25ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-V7UBHM SCHEMBL29348510 3-[2-Chloro-3-[4-[(3-methyl-2-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348510 CC1CCCN(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C1=O Degrader C24H25ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-DIR5Y4 SCHEMBL29348511 3-[2-Chloro-3-[4-[(5-methyl-2-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348511 CC1CCC(=O)N(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C1 Degrader C24H25ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-I2XOWW SCHEMBL29348512 3-[2-Chloro-3-[4-[(3-fluoro-2-oxopyrrolidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348512 O=C1CCC(c2cccc(-c3ccc(CN4CCC(F)C4=O)cc3)c2Cl)C(=O)N1 Degrader C22H20ClFN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-8WZIF5 WO2024151547-A1_290 3-[2-Chloro-3-[4-[(3-methyl-2-oxopyrrolidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione CC1CCN(Cc2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C1=O Degrader C23H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-4EOQMJ WO2024151547-A1_291 3-[2-Chloro-3-[4-[(2-oxo-3-azabicyclo[3.1.0]hexan-3-yl)methyl]phenyl]phenyl]piperidine-2,6-dione O=C1CCC(c2cccc(-c3ccc(CN4CC5CC5C4=O)cc3)c2Cl)C(=O)N1 Degrader C23H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-IFY421 WO2024151547-A1_292 3-[2-Chloro-3-[4-[(2,2-dimethyl-6-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione CC1(C)CCCC(=O)N1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C25H27ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-TXJ1Z7 SCHEMBL29348515 3-[2-Chloro-3-[4-[(6-oxo-5-azaspiro[3.4]octan-5-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348515 O=C1CCC(c2cccc(-c3ccc(CN4C(=O)CCC45CCC5)cc3)c2Cl)C(=O)N1 Degrader C25H25ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-3PUGOZ SCHEMBL29348516 3-[2-Chloro-3-[4-[(5-oxo-4-azaspiro[2.5]octan-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348516 O=C1CCC(c2cccc(-c3ccc(CN4C(=O)CCCC45CC5)cc3)c2Cl)C(=O)N1 Degrader C25H25ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-PGS92E SCHEMBL29348517 3-[2-Chloro-3-[4-[(2-methyl-6-oxopiperidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348517 CC1CCCC(=O)N1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C24H25ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-EUCRVB SCHEMBL29348518 3-[2-Chloro-3-[4-[(5-oxo-4-azaspiro[2.4]heptan-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348518 O=C1CCC(c2cccc(-c3ccc(CN4C(=O)CCC45CC5)cc3)c2Cl)C(=O)N1 Degrader C24H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-OOP5KI WO2024151547-A1_297 3-[2-Chloro-3-[4-[(2-methyl-5-oxopyrrolidin-1-yl)methyl]phenyl]phenyl]piperidine-2,6-dione CC1CCC(=O)N1Cc1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C23H23ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-4B6I2Z SCHEMBL29348520 3-[2-chloro-3-[4-[(5-oxo-7H-pyrrolo[3,4-b]pyridin-6-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348520 O=C1CCC(c2cccc(-c3ccc(CN4Cc5ncccc5C4=O)cc3)c2Cl)C(=O)N1 Degrader C25H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-ZC0KJF WO2023078410-A1_5-23 . CC(C)(C)C(=O)NCC(C(=O)NCC1C=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC1)c1ccccc1 Degrader C28H34N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-ZX20G3 SCHEMBL29348521 3-[2-chloro-3-[4-[(7-oxo-5H-pyrrolo[3,4-b]pyridin-6-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348521 O=C1CCC(c2cccc(-c3ccc(CN4Cc5cccnc5C4=O)cc3)c2Cl)C(=O)N1 Degrader C25H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-LIRBFW SCHEMBL29348522 3-[2-chloro-3-[4-[(1-oxo-3H-pyrrolo[3,4-c]pyridin-2-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348522 O=C1CCC(c2cccc(-c3ccc(CN4Cc5cnccc5C4=O)cc3)c2Cl)C(=O)N1 Degrader C25H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-WYNU4X SCHEMBL29348523 3-[2-chloro-3-[4-[(3-oxo-1H-pyrrolo[3,4-c]pyridin-2-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348523 O=C1CCC(c2cccc(-c3ccc(CN4Cc5ccncc5C4=O)cc3)c2Cl)C(=O)N1 Degrader C25H20ClN3O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-G2D6OO SCHEMBL29348524 3-[2-Chloro-3-[4-[(3-oxomorpholin-4-yl)methyl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348524 O=C1CCC(c2cccc(-c3ccc(CN4CCOCC4=O)cc3)c2Cl)C(=O)N1 Degrader C22H21ClN2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-N7E17M SCHEMBL26147603 N-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxo-2-phenylpropyl]benzamide\; SCHEMBL26147603 O=C1CCC(N2Cc3cc(CNC(=O)C(CNC(=O)c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C30H28N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-4HM04J WO2024151547-A1_303 3-[2-chloro-3-[4-[(2R)-2-methyl-5-oxopyrrolidin-1-yl]phenyl]phenyl]piperidine-2,6-dione C[C@@H]1CCC(=O)N1c1ccc(-c2cccc(C3CCC(=O)NC3=O)c2Cl)cc1 Degrader C22H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-YIEFH2 SCHEMBL26148778 cyclopentyl N-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxo-2-phenylpropyl]carbamate\; SCHEMBL26148778 O=C1CCC(N2Cc3cc(CNC(=O)C(CNC(=O)OC4CCCC4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C29H32N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-H0HNT1 WO2024151547-A1_304 3-[2-Chloro-3-[4-(3-methyl-2-oxopyrrolidin-1-yl)phenyl]phenyl]piperidine-2,6-dione CC1CCN(c2ccc(-c3cccc(C4CCC(=O)NC4=O)c3Cl)cc2)C1=O Degrader C22H21ClN2O3 VAV1 P15498 CRBN WO-2024151547-A1 TPD-1ZHI72 SCHEMBL29348527 3-[2-Chloro-3-[4-[3-oxo-5-(trifluoromethyl)morpholin-4-yl]phenyl]phenyl]piperidine-2,6-dione\; SCHEMBL29348527 O=C1CCC(c2cccc(-c3ccc(N4C(=O)COCC4C(F)(F)F)cc3)c2Cl)C(=O)N1 Degrader C22H18ClF3N2O4 VAV1 P15498 CRBN WO-2024151547-A1 TPD-MKPU9Y SCHEMBL26147605 N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl]cyclopentanecarboxamide\; SCHEMBL26147605 O=C1CCC(N2Cc3cc(CNC(=O)C(NC(=O)C4CCCC4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C28H30N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-BM4A6B WO2024193641-A1_1 . O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccnc(-n7ccnc7)n6)CC5)cc4)cccc3C2=O)C(=O)N1 Degrader C32H32N8O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-F0KOL0 WO2024193641-A1_10 . Cc1cc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)nc(-n2ccnc2)n1 Degrader C36H34N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-RLAI2B WO2024193641-A1_11 . CC1C=C(C(=O)N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)N=C(n2ccnc2)N1 Degrader C37H36N8O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-5YWPMS WO2024193641-A1_12 . Cc1cc(C(=O)NC2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)nc(-n2ccnc2)n1 Degrader C38H36N8O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-ME0BUQ WO2024193641-A1_13 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(c7ccnc(-n8ccnc8C(F)(F)F)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C36H31F3N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-I1EZKY WO2024193641-A1_14 . O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCN(C(=O)c6ccnc(-n7ccnc7)n6)CC5)cc4)cccc3C2=O)C(=O)N1 Degrader C33H32N8O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-0QL98L SCHEMBL26147510 tert-butyl N-[(2S)-1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-1-oxo-3-phenylpropan-2-yl]carbamate\; SCHEMBL26147510 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C28H32N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-M39O3U WO2024193641-A1_15 . O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCN([C@H]6CC[C@H](NC(=O)c7ccnc(-n8ccnc8)n7)CC6)CC5)cc4)cccc3C2=O)C(=O)N1 Degrader C39H43N9O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-5O25L1 WO2024193641-A1_16 . O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCN([C@H]6CC[C@H](NC(=O)c7cccc(-n8ccnc8)n7)CC6)CC5)cc4)cccc3C2=O)C(=O)N1 Degrader C40H44N8O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-SKMAQC SCHEMBL26147508 propan-2-yl N-[(2S)-1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-1-oxo-3-phenylpropan-2-yl]carbamate\; SCHEMBL26147508 CC(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C27H30N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-RM1C08 WO2024193641-A1_17 . O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCN(CC6CCN(c7cccc(-n8ccnc8)n7)CC6)CC5)cc4)cccc3C2=O)C(=O)N1 Degrader C39H44N8O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-6PCRUO WO2024193641-A1_18 . O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCC(N6CCC(NC(=O)c7ccnc(-n8ccnc8)n7)CC6)CC5)cc4)cccc3C2=O)C(=O)N1 Degrader C39H43N9O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-JB05OZ WO2024193641-A1_19 . O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCN(c6cccc(-c7cncs7)n6)CC5)cc4)cccc3C2=O)C(=O)N1 Degrader C33H32N6O4S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-U8IAA7 SCHEMBL26147672 tert-butyl N-[2-(4-chlorophenyl)-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxopropyl]carbamate\; SCHEMBL26147672 CC(C)(C)OC(=O)NCC(C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccc(Cl)cc1 Degrader C28H31ClN4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-10VPXB WO2024193641-A1_2 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(c7cccc(-n8ccnc8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C36H33N7O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-2ZH8RV WO2024193641-A1_20 . Cn1cncc1-c1nccc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)n1 Degrader C36H34N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-WDW474 WO2023078410-A1_5-46 . CC(C)(C)OC(=O)NC(CC1CCCCC1)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O Degrader C28H38N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-7P09SP WO2024193641-A1_21 . Cc1ncc(-c2nc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6C5CCC(=O)NC5=O)cc4)CC3)cc(C(C)(F)F)n2)s1 Degrader C38H35F2N7O3S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-C79M8A WO2024193641-A1_22 3-[6-[[4-[[4-[6-(5-Methyl-1,3,4-thiadiazol-2-yl)pyridin-2-yl]piperazin-1-yl]methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione Cc1nnc(-c2cccc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6C5CCC(=O)NC5=O)cc4)CC3)n2)s1 Degrader C36H33N7O3S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-A1745Q WO2024193641-A1_23 3-[6-[[4-[[4-[6-(3-Methyl-1,2,4-triazol-1-yl)pyridin-2-yl]piperazin-1-yl]methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione Cc1ncn(-c2cccc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6C5CCC(=O)NC5=O)cc4)CC3)n2)n1 Degrader C36H34N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-PINX2Q SCHEMBL26147853 (2S)-2-[(2-cyclopentylacetyl)-methylamino]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-phenylacetamide\; SCHEMBL26147853 CN(C(=O)CC1CCCC1)[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C30H34N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-F6N1DS WO2024193641-A1_24 . CC(C)n1cnnc1-c1cccc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)n1 Degrader C38H38N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-O18XN7 WO2024193641-A1_25 3-[2-Oxo-6-[[4-[[4-[2-[4-(trifluoromethyl)imidazol-1-yl]pyrimidin-4-yl]piperazin-1-yl]methyl]phenyl]methyl]benzo[cd]indol-1-yl]piperidine-2,6-dione O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(c7ccnc(-n8cnc(C(F)(F)F)c8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C36H31F3N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-O03KT4 SCHEMBL26147544 N-[3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxo-2-phenylpropyl]cyclopentanecarboxamide\; SCHEMBL26147544 O=C1CCC(N2Cc3cc(CNC(=O)C(CNC(=O)C4CCCC4)c4ccccc4)ccc3C2=O)C(=O)N1 Degrader C29H32N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-RCCYY9 WO2024193641-A1_26 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(c7ccnc(-n8cnc(C9CC9)c8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C38H36N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-0UNN8M WO2024193641-A1_27 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCC(O[C@H]7CC[C@@H](NC(=O)c8cccc(-n9ccnc9)n8)CC7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C44H45N7O5 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-NB298C WO2024193641-A1_28 . Cc1nncn1-c1cccc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)n1 Degrader C36H34N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-1H21BH SCHEMBL26147184 tert-butyl N-[(1S)-1-cyclohexyl-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxoethyl]carbamate\; SCHEMBL26147184 CC(C)(C)OC(=O)N[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCCCC1 Degrader C27H36N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-SAFRW7 WO2024193641-A1_29 3-[6-[[4-[[4-[2-Methyl-6-[4-(trifluoromethyl)imidazol-1-yl]pyrimidin-4-yl]piperazin-1-yl]methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione Cc1nc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5C4CCC(=O)NC4=O)cc3)CC2)cc(-n2cnc(C(F)(F)F)c2)n1 Degrader C37H33F3N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-SEOTEY WO2024193641-A1_3 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(c7ccnc(-n8ccnc8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C35H32N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-L7UR3V WO2024193641-A1_30 (3S)-3-[6-[[4-[[4-[2-methyl-6-[4-(trifluoromethyl)imidazol-1-yl]pyrimidin-4-yl]piperazin-1-yl]methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione Cc1nc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5[C@H]4CCC(=O)NC4=O)cc3)CC2)cc(-n2cnc(C(F)(F)F)c2)n1 Degrader C37H33F3N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-WH32R8 SCHEMBL26147755 N-[2-cyclohexyl-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxopropyl]cyclopentanecarboxamide\; SCHEMBL26147755 O=C1CCC(N2Cc3cc(CNC(=O)C(CNC(=O)C4CCCC4)C4CCCCC4)ccc3C2=O)C(=O)N1 Degrader C29H38N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-M9IZ0B WO2024193641-A1_31 (3R)-3-[6-[[4-[[4-[2-methyl-6-[4-(trifluoromethyl)imidazol-1-yl]pyrimidin-4-yl]piperazin-1-yl]methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione Cc1nc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5[C@@H]4CCC(=O)NC4=O)cc3)CC2)cc(-n2cnc(C(F)(F)F)c2)n1 Degrader C37H33F3N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-WSBDBV WO2024193641-A1_32 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CC(N7CCN(c8cccc(-n9ccnc9)n8)CC7)C6)cc5)ccc2c34)C(=O)N1 Degrader C39H38N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-3M0W5V WO2024193641-A1_33 (3S)-3-[2-oxo-6-[[4-[[4-[2-[4-(trifluoromethyl)imidazol-1-yl]pyrimidin-4-yl]piperazin-1-yl]methyl]phenyl]methyl]benzo[cd]indol-1-yl]piperidine-2,6-dione O=C1CC[C@H](N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(c7ccnc(-n8cnc(C(F)(F)F)c8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C36H31F3N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-MB718M WO2024193641-A1_34 (3R)-3-[2-oxo-6-[[4-[[4-[2-[4-(trifluoromethyl)imidazol-1-yl]pyrimidin-4-yl]piperazin-1-yl]methyl]phenyl]methyl]benzo[cd]indol-1-yl]piperidine-2,6-dione O=C1CC[C@@H](N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(c7ccnc(-n8cnc(C(F)(F)F)c8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C36H31F3N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-4IUQX1 WO2024193641-A1_35 (3S)-3-[6-[[4-[[4-[6-(5-methyl-1,3,4-thiadiazol-2-yl)pyridin-2-yl]piperazin-1-yl]methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione Cc1nnc(-c2cccc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6[C@H]5CCC(=O)NC5=O)cc4)CC3)n2)s1 Degrader C36H33N7O3S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-S2LDL3 WO2024193641-A1_36 (3R)-3-[6-[[4-[[4-[6-(5-methyl-1,3,4-thiadiazol-2-yl)pyridin-2-yl]piperazin-1-yl]methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione Cc1nnc(-c2cccc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6[C@@H]5CCC(=O)NC5=O)cc4)CC3)n2)s1 Degrader C36H33N7O3S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-HP3UHS WO2024193641-A1_37 (3S)-3-[6-[[4-[[4-[6-(3-methyl-1,2,4-triazol-1-yl)pyridin-2-yl]piperazin-1-yl]methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione Cc1ncn(-c2cccc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6[C@H]5CCC(=O)NC5=O)cc4)CC3)n2)n1 Degrader C36H34N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-D1CLXW WO2024193641-A1_38 (3R)-3-[6-[[4-[[4-[6-(3-methyl-1,2,4-triazol-1-yl)pyridin-2-yl]piperazin-1-yl]methyl]phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione Cc1ncn(-c2cccc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6[C@@H]5CCC(=O)NC5=O)cc4)CC3)n2)n1 Degrader C36H34N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-DCQB69 WO2024193641-A1_39 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(c7ccnc(-n8cnc(C(F)(F)F)n8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C35H30F3N9O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-INED4H WO2024193641-A1_4 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(C(=O)c7cccc(-n8ccnc8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C37H33N7O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-9CIIYI WO2024193641-A1_40 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(C7CCN(c8ccnc(-n9cnc(C(F)(F)F)c9)n8)CC7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C41H40F3N9O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-ZWQS99 WO2024193641-A1_41 . Cc1ncn(-c2nccc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6C5CCC(=O)NC5=O)cc4)CC3)n2)n1 Degrader C35H33N9O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-8D2P1I SCHEMBL26147859 tert-butyl [(1S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-2-oxo-1-phenylethyl] carbonate\; SCHEMBL26147859 CC(C)(C)OC(=O)O[C@H](C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)c1ccccc1 Degrader C27H29N3O7 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-LW3U3Z WO2024193641-A1_42 . Cc1nnc(-c2ncc(F)c(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6C5CCC(=O)NC5=O)cc4)CC3)n2)s1 Degrader C35H31FN8O3S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-15T5CB WO2024193641-A1_43 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(c7ccnc(-n8cnc(Cl)c8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C35H31ClN8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-0EMATB WO2024193641-A1_44 . N#Cc1cn(-c2nccc(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6C5CCC(=O)NC5=O)cc4)CC3)n2)cn1 Degrader C36H31N9O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-G61DUI WO2024193641-A1_45 . Cc1ncn(-c2ncc(Cl)c(N3CCN(Cc4ccc(Cc5ccc6c7c(cccc57)C(=O)N6C5CCC(=O)NC5=O)cc4)CC3)n2)n1 Degrader C35H32ClN9O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-I5MBYW WO2024220708-A1_1 3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-pyridazin-3-yloxy-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1nccc(CN2Cc3ccc(Oc4cccnn4)cc3OC2=O)c1F Stabilizer C19H17FN6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-4EW6OL WO2024220708-A1_10 3-[[3-Fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(1,2,4-triazin-3-yloxy)spiro[1,3-benzoxazine-4,3'-oxetane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4nccnn4)ccc3C23COC3)c1F Stabilizer C20H18FN7O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-T903LM SCHEMBL26147879 (2S)-3-cyclohexyl-2-[(2-cyclopentylacetyl)amino]-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]propanamide\; SCHEMBL26147879 O=C1CCC(N2Cc3cc(CNC(=O)[C@H](CC4CCCCC4)NC(=O)CC4CCCC4)ccc3C2=O)C(=O)N1 Degrader C30H40N4O5 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-CESACV WO2024220708-A1_100 . COC1CCN(S(=O)(=O)Nc2cccc(CN3Cc4ccc(OC(=O)N(C)C)cc4OC3=O)c2F)C1 Stabilizer C23H27FN4O7S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-TMG5D1 WO2024220708-A1_101 2,2-difluoro-2-[3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl]-N-methylacetamide CNC(=O)C(F)(F)c1ccc2c(c1)OC(=O)N(Cc1cccc(NS(=O)(=O)NC)c1F)C2 Stabilizer C19H19F3N4O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-DKYNOG WO2024220708-A1_102 [3-[[3-(cyclopropylsulfonylamino)-2-fluorophenyl]methyl]-5-fluoro-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CN(C)C(=O)Oc1cc(F)c2c(c1)OC(=O)N(Cc1cccc(NS(=O)(=O)C3CC3)c1F)C2 Stabilizer C21H21F2N3O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-WLXY0Y WO2024220708-A1_104 . CNS(=O)(=O)Nc1cccc(CN2C(=O)Oc3c(ccc(OC(=O)N(C)C)c3F)C2C)c1F Stabilizer C20H22F2N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-WH8VE2 WO2024220708-A1_105 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-pyridazin-3-yloxy-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(Oc4cccnn4)cc3OC2=O)c1F Stabilizer C20H18FN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-2JR1N3 SCHEMBL26147913 tert-butyl N-[1-cyclopentyl-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methylamino]-3-oxopropyl]carbamate\; SCHEMBL26147913 CC(C)(C)OC(=O)NC(CC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O)C1CCCC1 Degrader C27H36N4O6 GSPT1 P15170 CRBN WO-2023078410-A1 TPD-68Z71G WO2024220708-A1_106 7-(cyclopropylmethoxy)-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(OCC4CC4)cc3OC2=O)c1F Stabilizer C20H22FN3O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-S3GCQT WO2024220708-A1_107 . CNS(=O)(=O)Nc1cccc(CN2C(=O)Oc3cc(OC(=O)N(C)C)c(Cl)cc3C2C)c1F Stabilizer C20H22ClFN4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-8WX9DX WO2024220708-A1_108 . CNC(=O)Oc1cc2c(cc1Cl)C(C)N(Cc1cccc(NS(=O)(=O)NC)c1F)C(=O)O2 Stabilizer C19H20ClFN4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-3HE207 WO2024220708-A1_109 [3-[[2-fluoro-3-(2-oxa-6-azaspiro[3.3]heptan-6-ylsulfonylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CN(C)C(=O)Oc1ccc2c(c1)OC(=O)N(Cc1cccc(NS(=O)(=O)N3CC4(COC4)C3)c1F)C2 Stabilizer C23H25FN4O7S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-TPYNO7 WO2024220708-A1_11 methyl N-[2-fluoro-3-[(2-oxo-7-pyridazin-3-yloxy-4H-1,3-benzoxazin-3-yl)methyl]phenyl]carbamate COC(=O)Nc1cccc(CN2Cc3ccc(Oc4cccnn4)cc3OC2=O)c1F Stabilizer C21H17FN4O5 BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-XPZGUZ WO2024220708-A1_110 [3-[[2-fluoro-3-(morpholin-4-ylsulfonylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CN(C)C(=O)Oc1ccc2c(c1)OC(=O)N(Cc1cccc(NS(=O)(=O)N3CCOCC3)c1F)C2 Stabilizer C22H25FN4O7S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-YQDVO1 WO2024220708-A1_111 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-6-methyl-7-pyrimidin-2-yloxy-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3cc(C)c(Oc4ncccn4)cc3OC2=O)c1F Stabilizer C21H20FN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-IW1EFW WO2024220708-A1_112 [3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-6-methyl-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2Cc3cc(C)c(OC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C20H23FN4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-0KDPAB WO2024220708-A1_113 [3-[[2-fluoro-3-[(3-fluoropyrrolidin-1-yl)sulfonylamino]phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CN(C)C(=O)Oc1ccc2c(c1)OC(=O)N(Cc1cccc(NS(=O)(=O)N3CCC(F)C3)c1F)C2 Stabilizer C22H24F2N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-SYE1KI WO2024220708-A1_114 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-N-methyl-2-oxo-4H-1,3-benzoxazine-7-carboxamide CNC(=O)c1ccc2c(c1)OC(=O)N(Cc1cccc(NS(=O)(=O)NC)c1F)C2 Stabilizer C18H19FN4O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-NKFCG2 WO2024220708-A1_115 [3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxospiro[1,3-benzoxazine-4,3'-oxetane]-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2C(=O)Oc3cc(OC(=O)N(C)C)ccc3C23COC3)c1F Stabilizer C21H23FN4O7S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-HB3V0N WO2024220708-A1_116 [3-[[2-fluoro-3-(2-oxo-1H-pyridin-3-yl)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CN(C)C(=O)Oc1ccc2c(c1)OC(=O)N(Cc1cccc(-c3ccc[nH]c3=O)c1F)C2 Stabilizer C23H20FN3O5 BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-6F8EFE WO2024220708-A1_117 5-fluoro-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-pyrimidin-2-yloxy-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3c(F)cc(Oc4ncccn4)cc3OC2=O)c1F Stabilizer C20H17F2N5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-NOHIHG WO2024220708-A1_118 [5-fluoro-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2Cc3c(F)cc(OC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C19H20F2N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-7F37C6 WO2024220708-A1_119 [3-[[2-fluoro-3-(2-methoxyethylcarbamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate COCCNC(=O)Nc1cccc(CN2Cc3ccc(OC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C22H25FN4O6 BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-IKS362 WO2024220708-A1_120 [6-fluoro-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2Cc3cc(F)c(OC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C19H20F2N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-HOK84A WO2024220708-A1_121 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-N,N-dimethyl-2-oxo-4H-1,3-benzoxazine-7-carboxamide CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(C(=O)N(C)C)cc3OC2=O)c1F Stabilizer C19H21FN4O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-P9I5JP WO2024220708-A1_122 N-[3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl]-1H-pyrazole-4-carboxamide CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(NC(=O)c4cn[nH]c4)cc3OC2=O)c1F Stabilizer C20H19FN6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-6H7RAL WO2024220708-A1_123 8-fluoro-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-pyrimidin-2-yloxy-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(Oc4ncccn4)c(F)c3OC2=O)c1F Stabilizer C20H17F2N5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-JZ17EV WO2024220708-A1_124 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-[(2-oxopyrrolidin-1-yl)methyl]-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(CN4CCCC4=O)cc3OC2=O)c1F Stabilizer C21H23FN4O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-2ENGBQ WO2024220708-A1_125 [3-[[3-(cyclopropylsulfonylamino)-2-fluorophenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CN(C)C(=O)Oc1ccc2c(c1)OC(=O)N(Cc1cccc(NS(=O)(=O)C3CC3)c1F)C2 Stabilizer C21H22FN3O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-ABT6YE WO2024220708-A1_126 [3-[[2-fluoro-3-[(2,2,2-trifluoroacetyl)amino]phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CN(C)C(=O)Oc1ccc2c(c1)OC(=O)N(Cc1cccc(NC(=O)C(F)(F)F)c1F)C2 Stabilizer C20H17F4N3O5 BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-K901MN WO2024220708-A1_127 [3-[[3-[(2,2-difluorocyclopropanecarbonyl)amino]-2-fluorophenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CN(C)C(=O)Oc1ccc2c(c1)OC(=O)N(Cc1cccc(NC(=O)C3CC3(F)F)c1F)C2 Stabilizer C22H20F3N3O5 BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-3YIZM9 WO2024220708-A1_128 [3-[[2-fluoro-3-(methylcarbamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNC(=O)Nc1cccc(CN2Cc3ccc(OC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C20H21FN4O5 BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-R5MPMG WO2024220708-A1_129 [6-chloro-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] 2-methylpropanoate CNS(=O)(=O)Nc1cccc(CN2Cc3cc(Cl)c(OC(=O)C(C)C)cc3OC2=O)c1F Stabilizer C20H21ClFN3O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-KYVHXA WO2024220708-A1_13 . CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4cccnn4)c(F)cc3C2C)c1F Stabilizer C20H18F2N6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-QLIOBN WO2024220708-A1_130 [6-chloro-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] cyclopropanecarboxylate CNS(=O)(=O)Nc1cccc(CN2Cc3cc(Cl)c(OC(=O)C4CC4)cc3OC2=O)c1F Stabilizer C20H19ClFN3O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-RNCG1U WO2024220708-A1_131 [8-fluoro-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(OC(=O)N(C)C)c(F)c3OC2=O)c1F Stabilizer C19H20F2N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-UN2ZLH WO2024220708-A1_132 [3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-pyrido[2,3-e][1,3]oxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2Cc3ncc(OC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C18H20FN5O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-JSZD33 WO2024220708-A1_133 2,2-difluoro-2-[3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl]-N,N-dimethylacetamide CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(C(F)(F)C(=O)N(C)C)cc3OC2=O)c1F Stabilizer C20H21F3N4O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-CA9BKL WO2024220708-A1_134 2-[3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl]-N,N-dimethylacetamide CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(CC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C20H23FN4O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-7FBNYU WO2024220708-A1_135 1-[3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl]-1,3,3-trimethylurea CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(N(C)C(=O)N(C)C)cc3OC2=O)c1F Stabilizer C20H24FN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-PWM4AF WO2024220708-A1_136 3-[3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl]-1,1-dimethylurea CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(NC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C19H22FN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-VYRVZI WO2024220708-A1_137 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-[(2-oxopyridin-1-yl)methyl]-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(Cn4ccccc4=O)cc3OC2=O)c1F Stabilizer C22H21FN4O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-XA3YZ5 WO2024220708-A1_138 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-(2-oxopiperidin-1-yl)-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(N4CCCCC4=O)cc3OC2=O)c1F Stabilizer C21H23FN4O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-YSPMDA WO2024220708-A1_139 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-(2-oxopyridin-1-yl)-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(-n4ccccc4=O)cc3OC2=O)c1F Stabilizer C21H19FN4O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-81DW06 WO2024220708-A1_14 . CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(Oc4nccnn4)cc3OC2=O)c1F Stabilizer C19H17FN6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-3UGH7C WO2024220708-A1_141 . CNS(=O)(=O)Nc1cccc(C(C)N2Cc3ccc(Oc4ncccn4)cc3OC2=O)c1F Stabilizer C21H20FN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-IIWNCQ WO2024220708-A1_142 [3-[1-[2-fluoro-3-(methylsulfamoylamino)phenyl]ethyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(C(C)N2Cc3ccc(OC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C20H23FN4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-HFUDL4 WO2024220708-A1_145 [3-[1-[3-(methylsulfamoylamino)phenyl]ethyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(C(C)N2Cc3ccc(OC(=O)N(C)C)cc3OC2=O)c1 Stabilizer C20H24N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-DSFRUG WO2024220708-A1_146 [3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] 3,3-difluoroazetidine-1-carboxylate CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(OC(=O)N4CC(F)(F)C4)cc3OC2=O)c1F Stabilizer C20H19F3N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-ADPPV0 WO2024220708-A1_147 [3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] cyclopropanecarboxylate CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(OC(=O)C4CC4)cc3OC2=O)c1F Stabilizer C20H20FN3O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-T9K7QM WO2024220708-A1_148 6-chloro-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-pyrimidin-2-yloxy-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3cc(Cl)c(Oc4ncccn4)cc3OC2=O)c1F Stabilizer C20H17ClFN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-MTAN2G WO2024220708-A1_149 [6-chloro-3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2Cc3cc(Cl)c(OC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C19H20ClFN4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-MLP4JG WO2024220708-A1_15 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-pyridazin-3-yloxy-4H-pyrido[2,3-e][1,3]oxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ncc(Oc4cccnn4)cc3OC2=O)c1F Stabilizer C19H17FN6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-NSJGVI WO2024220708-A1_151 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-4-methyl-7-pyrimidin-2-yloxy-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2C(=O)Oc3cc(Oc4ncccn4)ccc3C2C)c1F Stabilizer C21H20FN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-R2HB2F WO2024220708-A1_153 [3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-4-methyl-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2C(=O)Oc3cc(OC(=O)N(C)C)ccc3C2C)c1F Stabilizer C20H23FN4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-KBPHEO WO2024220708-A1_155 . CNS(=O)(=O)Nc1cccc(CN2C(=O)Oc3cc(OC(=O)N(C)C)ccc3C2C)c1 Stabilizer C20H24N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-QTCO6L WO2024220708-A1_156 [3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(OC(=O)N(C)C)cc3OC2=O)c1F Stabilizer C19H21FN4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-8EBJA6 SCHEMBL25389362 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-pyrimidin-2-yloxy-4H-1,3-benzoxazin-2-one\; SCHEMBL25389362 CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(Oc4ncccn4)cc3OC2=O)c1F Stabilizer C20H18FN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-UOGDBE WO2024220708-A1_158 [3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-4H-1,3-benzoxazin-7-yl] N,N-dimethylcarbamate CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(OC(=O)N(C)C)cc3OC2=O)c1 Stabilizer C19H22N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-D628QS WO2024220708-A1_159 3-[[3-(methylsulfamoylamino)phenyl]methyl]-7-pyrimidin-2-yloxy-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(Oc4ncccn4)cc3OC2=O)c1 Stabilizer C20H19N5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-ZL7S91 WO2024220708-A1_16 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-(1-methylpyrazol-3-yl)oxy-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1cccc(CN2Cc3ccc(Oc4ccn(C)n4)cc3OC2=O)c1F Stabilizer C20H20FN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-YCYCXE WO2024220708-A1_160 3-[[3-Fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-pyrimidin-2-yloxyspiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4ncccn4)ccc3C23CCC3)c1F Stabilizer C22H21FN6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-IG4HC4 WO2024220708-A1_161 N-[3-fluoro-4-[[2-oxo-7-(1,2,4-triazin-3-yloxy)spiro[1,3-benzoxazine-4,1'-cyclobutane]-3-yl]methyl]pyridin-2-yl]cyclopropanesulfonamide O=C1Oc2cc(Oc3nccnn3)ccc2C2(CCC2)N1Cc1ccnc(NS(=O)(=O)C2CC2)c1F Stabilizer C23H21FN6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-L08HH0 WO2024220708-A1_162 3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(1,3-oxazol-2-yloxy)-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1nccc(CN2Cc3ccc(Oc4ncco4)cc3OC2=O)c1F Stabilizer C18H16FN5O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-IKVQUC WO2024220708-A1_163 N-[3-fluoro-4-[(2-oxo-7-pyridazin-3-yloxyspiro[1,3-benzoxazine-4,1'-cyclobutane]-3-yl)methyl]pyridin-2-yl]cyclopropanesulfonamide O=C1Oc2cc(Oc3cccnn3)ccc2C2(CCC2)N1Cc1ccnc(NS(=O)(=O)C2CC2)c1F Stabilizer C24H22FN5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-PJ0J61 WO2024220708-A1_164 3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(1,2,4-triazin-3-yloxy)-4H-1,3-benzoxazin-2-one CNS(=O)(=O)Nc1nccc(CN2Cc3ccc(Oc4nccnn4)cc3OC2=O)c1F Stabilizer C18H16FN7O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-M2PC56 WO2024220708-A1_165 6-Fluoro-3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(1,3-oxazol-2-yloxy)spiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4ncco4)c(F)cc3C23CCC3)c1F Stabilizer C21H19F2N5O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-KHR8KK WO2024220708-A1_166 6-Fluoro-3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(1,2,4-triazin-3-yloxy)spiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4nccnn4)c(F)cc3C23CCC3)c1F Stabilizer C21H19F2N7O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-ZYAO5L WO2024220708-A1_167 N-[3-fluoro-4-[[7-(1,3-oxazol-2-yloxy)-2-oxospiro[1,3-benzoxazine-4,1'-cyclobutane]-3-yl]methyl]pyridin-2-yl]cyclopropanesulfonamide O=C1Oc2cc(Oc3ncco3)ccc2C2(CCC2)N1Cc1ccnc(NS(=O)(=O)C2CC2)c1F Stabilizer C23H21FN4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-IAAPLY WO2024220708-A1_168 5-Fluoro-3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(1,3-oxazol-2-yloxy)spiro[1,3-benzoxazine-4,3'-oxetane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4ncco4)cc(F)c3C23COC3)c1F Stabilizer C20H17F2N5O7S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-JPRVBL WO2024220708-A1_169 5-Fluoro-3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(1,3-oxazol-2-yloxy)spiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4ncco4)cc(F)c3C23CCC3)c1F Stabilizer C21H19F2N5O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-ZO7HUN WO2024220708-A1_17 3-[[2-Fluoro-3-(methylsulfamoylamino)phenyl]methyl]-7-(1,3-oxazol-2-yloxy)spiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1cccc(CN2C(=O)Oc3cc(Oc4ncco4)ccc3C23CCC3)c1F Stabilizer C22H21FN4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-4MUZEI WO2024220708-A1_170 N-[3-fluoro-4-[[6-fluoro-7-(1,3-oxazol-2-yloxy)-2-oxospiro[1,3-benzoxazine-4,1'-cyclobutane]-3-yl]methyl]pyridin-2-yl]cyclopropanesulfonamide O=C1Oc2cc(Oc3ncco3)c(F)cc2C2(CCC2)N1Cc1ccnc(NS(=O)(=O)C2CC2)c1F Stabilizer C23H20F2N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-YK10DU WO2024220708-A1_171 5-Fluoro-3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-pyridazin-3-yloxyspiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4cccnn4)cc(F)c3C23CCC3)c1F Stabilizer C22H20F2N6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-SGPPVF WO2024220708-A1_172 N-[3-fluoro-4-[[6-fluoro-7-(1,3-oxazol-2-yloxy)-2-oxospiro[1,3-benzoxazine-4,3'-oxetane]-3-yl]methyl]pyridin-2-yl]cyclopropanesulfonamide O=C1Oc2cc(Oc3ncco3)c(F)cc2C2(COC2)N1Cc1ccnc(NS(=O)(=O)C2CC2)c1F Stabilizer C22H18F2N4O7S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-GVX4R1 WO2024220708-A1_173 8-Fluoro-3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(1,3-oxazol-2-yloxy)spiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3c(ccc(Oc4ncco4)c3F)C23CCC3)c1F Stabilizer C21H19F2N5O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-YA6TI9 WO2024220708-A1_174 8-Fluoro-3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-pyridazin-3-yloxyspiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3c(ccc(Oc4cccnn4)c3F)C23CCC3)c1F Stabilizer C22H20F2N6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-U8LXNW WO2024220708-A1_176 3-[[2-fluoro-3-(methylsulfamoylamino)phenyl]methyl]-4-methyl-7-pyridazin-3-yloxy-4H-pyrido[2,3-e][1,3]oxazin-2-one CNS(=O)(=O)Nc1cccc(CN2C(=O)Oc3cc(Oc4cccnn4)cnc3C2C)c1F Stabilizer C20H19FN6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-LGV01S WO2024220708-A1_177 8-Fluoro-3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(1,2,4-triazin-3-yloxy)spiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3c(ccc(Oc4nccnn4)c3F)C23CCC3)c1F Stabilizer C21H19F2N7O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-WYLF7C WO2024220708-A1_178 . CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4cccnn4)cc(F)c3C23COC3)c1F Stabilizer C21H18F2N6O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-QC2F5S WO2024220708-A1_179 3-[[2-(Dimethylsulfamoylamino)-3-fluoropyridin-4-yl]methyl]-7-(1,3-oxazol-2-yloxy)-2-oxospiro[1,3-benzoxazine-4,1'-cyclobutane] CN(C)S(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4ncco4)ccc3C23CCC3)c1F Stabilizer C22H22FN5O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-ZWY4DN WO2024220708-A1_18 6-Fluoro-3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-pyridazin-3-yloxyspiro[1,3-benzoxazine-4,3'-oxetane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4cccnn4)c(F)cc3C23COC3)c1F Stabilizer C21H18F2N6O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-BGXHTK WO2024220708-A1_180 3-[[3-Fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-[(5-methyl-1,3-oxazol-2-yl)oxy]spiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4ncc(C)o4)ccc3C23CCC3)c1F Stabilizer C22H22FN5O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-SGC8XX WO2024220708-A1_181 3-[[2-(Dimethylsulfamoylamino)-3-fluoropyridin-4-yl]methyl]-2-oxo-7-pyridazin-3-yloxyspiro[1,3-benzoxazine-4,1'-cyclobutane] CN(C)S(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4cccnn4)ccc3C23CCC3)c1F Stabilizer C23H23FN6O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-7I4BVR WO2024220708-A1_182 3-[[3-Fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-[(4-methyl-1,3-oxazol-2-yl)oxy]spiro[1,3-benzoxazine-4,1'-cyclobutane]-2-one CNS(=O)(=O)Nc1nccc(CN2C(=O)Oc3cc(Oc4nc(C)co4)ccc3C23CCC3)c1F Stabilizer C22H22FN5O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-BIYTWU WO2024220708-A1_183 N-[3-fluoro-4-[[8-fluoro-7-(1,3-oxazol-2-yloxy)-2-oxospiro[1,3-benzoxazine-4,1'-cyclobutane]-3-yl]methyl]pyridin-2-yl]cyclopropanesulfonamide O=C1Oc2c(ccc(Oc3ncco3)c2F)C2(CCC2)N1Cc1ccnc(NS(=O)(=O)C2CC2)c1F Stabilizer C23H20F2N4O6S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-RAAN6R WO2024220708-A1_184 N-[3-fluoro-4-[(8-fluoro-2-oxo-7-pyridazin-3-yloxyspiro[1,3-benzoxazine-4,1'-cyclobutane]-3-yl)methyl]pyridin-2-yl]cyclopropanesulfonamide O=C1Oc2c(ccc(Oc3cccnn3)c2F)C2(CCC2)N1Cc1ccnc(NS(=O)(=O)C2CC2)c1F Stabilizer C24H21F2N5O5S BRAF;MEK1 P15056/Q02750 . WO-2024220708-A1 TPD-QKR72G SCHEMBL31135332 3-[6-[[4-[(4-chlorophenyl)methyl]triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(CC5=CC=C(Cl)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H20ClN5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-5C1L0B SCHEMBL31135370 3-[6-[[4-[(3-bromophenyl)methyl]triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(CC5=CC(Br)=CC=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H20BrN5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-GCXVRB SCHEMBL31135342 3-[[1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]triazol-4-yl]methyl]benzonitrile N#CC1=CC=CC(CC2=CN(CC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)N=N2)=C1 Degrader C24H20N6O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-4MDSSG SCHEMBL31135344 3-[6-[[4-[(3-cyclopropylphenyl)methyl]triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(CC5=CC(C6CC6)=CC=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C26H25N5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-SV52YJ SCHEMBL31135340 4-[[1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]triazol-4-yl]methyl]benzonitrile N#CC1=CC=C(CC2=CN(CC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)N=N2)C=C1 Degrader C24H20N6O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-SIEU8E SCHEMBL31135357 3-[6-[[4-[(4,4-difluorocyclohexyl)methyl]triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(CC5CCC(F)(F)CC5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H25F2N5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-0MRK4C SCHEMBL31135325 3-[3-oxo-6-[[4-(piperidin-1-ylmethyl)triazol-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(CN5CCCCC5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H26N6O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-UG0KDY SCHEMBL31135347 3-[6-[[4-[difluoro(phenyl)methyl]triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(C(F)(F)C5=CC=CC=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H19F2N5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-ENWE0U WO2024222614A1_17 . O=C1CCC(N2CC3=CC(CN4C=C(C(F)(F)C5=CC=C(F)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H18F3N5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-J8MTI9 SCHEMBL31135331 3-[6-[[4-[difluoro-(6-methoxypyridin-2-yl)methyl]triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC1=CC=CC(C(F)(F)C2=CN(CC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)N=N2)=N1 Degrader C23H20F2N6O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-3A3WWA WO2024222614A1_19 . O=C1CCC(N2CC3=CC(CN4C=C(C(F)(F)C5=NC(C6CC6)=CC=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C25H22F2N6O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-MS0IDH WO2024222614A1_2 . O=C1CCC(N2CC3=CC(CN4C=C(CC5=CC(Cl)=CC=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H20ClN5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-3U0FSN WO2024222614A1_20 . CC1=NC=C(C(F)(F)C2=CN(CC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)N=N2)C=C1 Degrader C23H20F2N6O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-35INJS SCHEMBL31135345 3-[6-[[5-[(4-chlorophenyl)-difluoromethyl]-1,2,4-oxadiazol-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CC4=NOC(C(F)(F)C5=CC=C(Cl)C=C5)=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H17ClF2N4O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-TFG5IN SCHEMBL31135368 3-[6-[[3-[(4-chlorophenyl)methyl]-1,2,4-oxadiazol-5-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CC4=NC(CC5=CC=C(Cl)C=C5)=NO4)=C3)C2=O)C(=O)N1 Degrader C23H19ClN4O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-CR3VWN SCHEMBL31135326 3-[6-[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CC4=CN(CC5=CC=C(Cl)C=C5)N=N4)=C3)C2=O)C(=O)N1 Degrader C23H20ClN5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-II9YUS SCHEMBL31135362 3-[6-[[4-[(4-chlorophenyl)methyl]pyrazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(CC5=CC=C(Cl)C=C5)C=N4)=CC=C3C2=O)C(=O)N1 Degrader C24H21ClN4O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-CV1XG2 WO2024222614A1_25 . O=C1CCC(N2CC3=CC(CN4C=C(CC5=CC=CC=C5)C=N4)=CC=C3C2=O)C(=O)N1 Degrader C24H22N4O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-DY9C8N SCHEMBL31135351 3-[3-oxo-6-[[4-[[4-(trifluoromethoxy)phenyl]methyl]triazol-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL31135358 O=C1CCC(N2CC3=CC(CN4C=C(CC5=CC=C(OC(F)(F)F)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C24H20F3N5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-8XMZ9P SCHEMBL31135353 3-[6-[[4-[(4-chlorophenyl)-difluoromethyl]triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(C(F)(F)C5=CC=C(Cl)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H18ClF2N5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-T5M671 SCHEMBL31135374 3-[6-[[4-(4-fluorophenoxy)triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(OC5=CC=C(F)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H18FN5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-AB3SXS WO2024222614A1_29 . O=C1CCC(N2CC3=CC(CN4C=C(OC5=CC(Cl)=C(F)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H17ClFN5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-GE80LT SCHEMBL31280037 1-[6-[[4-(2,3-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(Cl)C(Cl)=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-N02C64 SCHEMBL31278979 5-[[4-(2,3-Dichlorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(Cl)C(Cl)=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0T65BK SCHEMBL31278834 1-[6-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCC(/C5=N/OC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H24FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9SDW2K SCHEMBL31279275 1-[6-[[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=NSC6=CC=CC=C65)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-C7XQ6O SCHEMBL31279396 1-[6-[[4-(1-benzothiophen-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C6C=CSC6=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-EQHNIO SCHEMBL31278968 1-[6-[[4-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CC=C(SC2=C(N3CCN(CC4=C/C5=C(\C=C/4)C(=O)N(N4CCC(=O)NC4=O)C5)CC3)C=CC=C2)C(C)=C1 Degrader C31H33N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-2TCP1F SCHEMBL31279146 1-[3-oxo-6-[(4-thiophen-2-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CC=C(C5=CC=CS5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-8NUE7X SCHEMBL31279514 1-[6-[[4-(5-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CC=C(C2=CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)S1 Degrader C23H24N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-FRY1MT SCHEMBL31279174 1-[6-[[4-(3-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=C(C2=CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)SC=C1 Degrader C23H24N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-T4EVHY SCHEMBL31279777 1-[3-oxo-6-[(4-thiophen-3-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CC=C(C5=CSC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-FL20ZH SCHEMBL31279761 1-[6-[[4-(4-methylthiophen-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CSC=C1C1=CCN(CC2=CC3=C(C=C2)C(=O)N(N2CCC(=O)NC2=O)C3)CC1 Degrader C23H24N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-RYPV9T SCHEMBL31279098 1-[6-[[4-(5-methylthiophen-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CC(C2=CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)=CS1 Degrader C23H24N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-VOSF8R SCHEMBL31279560 1-[6-[[4-(furan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CC=C(C5=CC=CO5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-2XE3QX SCHEMBL31279366 1-[6-[[4-(furan-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CC=C(C5=COC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-3A74YZ SCHEMBL31279175 1-[6-[(4-benzhydrylpiperazin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C(C5=CC=CC=C5)C5=CC=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C30H31N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-1FQJ6L SCHEMBL31280368 1-[3-oxo-6-[[4-[phenyl(pyridin-2-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C(C5=CC=CC=C5)C5=NC=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C29H30N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CQJPPB SCHEMBL31279386 1-[3-oxo-6-[[4-[phenyl(pyridin-4-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C(C5=CC=CC=C5)C5=CC=NC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C29H30N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-OCS33E SCHEMBL31279345 1-[6-[[4-(dipyridin-2-ylmethyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C(C5=CC=CC=N5)C5=NC=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H29N7O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-TS8UM0 SCHEMBL31279343 1-[6-[[4-(dipyridin-3-ylmethyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C(C5=CC=CN=C5)C5=CN=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H29N7O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-SPP94V SCHEMBL31279830 1-[6-[[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C(C5=CC=C(F)C=C5)C5=CC=C(F)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C30H29F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-SG1LPO SCHEMBL31279099 1-[6-[[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C(C5=CC=C(Cl)C=C5)C5=CC=C(Cl)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C30H29Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-17ZY6D SCHEMBL31279291 1-[6-[[(1S,4S)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4C[C@@H]5C[C@H]4CN5C(C4=CC=CC=C4)C4=CC=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C31H31N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-S5HTQQ SCHEMBL31279100 1-[3-oxo-6-[[4-(N-phenylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCC(N(C5=CC=CC=C5)C5=CC=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C30H31N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-1D2ELF SCHEMBL31278656 1-[3-oxo-6-[[4-(N-pyridin-2-ylanilino)piperidin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCC(N(C5=CC=CC=C5)C5=NC=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C29H30N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-6WKRZC SCHEMBL31278999 1-[6-[[4-[2-(4-chlorophenyl)anilino]piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(NC5=C(C6=CC=C(Cl)C=C6)C=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C30H30ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CPFXWG SCHEMBL31279892 1-[6-[[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1(C)CCC(CN2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)=C(C2=CC=C(Cl)C=C2)C1 Degrader C32H38ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-PQ21A8 SCHEMBL31279336 1-[3-oxo-6-[(4-thiophen-2-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=CS5)CC4)=C3)C2=O)C(=O)N1 Degrader C21H23N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-QKTU5M SCHEMBL31279309 1-[6-[[4-(5-methylthiophen-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CC=C(N2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)S1 Degrader C22H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-K56440 SCHEMBL31278923 1-[6-[[4-(3-methylthiophen-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=C(N2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)SC=C1 Degrader C22H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-2FPBPX SCHEMBL31279329 1-[3-oxo-6-[(4-thiophen-3-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CSC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C21H23N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-2Z9Y34 SCHEMBL31278863 1-[6-[[4-(4-methylthiophen-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CSC=C1N1CCN(CC2=CC3=C(C=C2)C(=O)N(N2CCC(=O)NC2=O)C3)CC1 Degrader C22H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-32N6GU SCHEMBL31279179 1-[6-[[4-(5-methylthiophen-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CC(N2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)=CS1 Degrader C22H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-AL0F6M SCHEMBL31280286 1-[3-oxo-6-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H24N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-BU1YYO SCHEMBL31278874 1-[6-[[4-(6-methylpyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=NC(N2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)=CC=C1 Degrader C23H26N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-D9OJIS SCHEMBL31279910 1-[6-[[4-(6-chloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=CC(Cl)=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23ClN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-XRHTSQ SCHEMBL31279005 1-[6-[[4-(5-chloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=C(Cl)C=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23ClN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-J63IOC SCHEMBL31279234 1-[6-[[4-(4-chloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC(Cl)=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23ClN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-TJT65B SCHEMBL31278538 1-[6-[[4-(3-fluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(F)C=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23FN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-FOUTHX SCHEMBL31279548 1-[6-[[4-(6-fluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=CC(F)=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23FN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-R6B8DF SCHEMBL31280371 1-[6-[[4-(5-fluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=C(F)C=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23FN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-WRT50J SCHEMBL31279909 5-[[4-[2-(2,4-Dimethylphenyl)sulfanylphenyl]piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione CC1=CC=C(SC2=C(N3CCN(CC4=C/C5=C(\C=C/4)C(=O)N(N4CCC(=O)NC4=O)C5=O)CC3)C=CC=C2)C(C)=C1 Degrader C31H31N5O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-SFMC89 SCHEMBL31279680 1-[6-[[3-(2,3-dichlorophenyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4C5CC4CN(C4=C(Cl)C(Cl)=CC=C4)C5)=C3)C2=O)C(=O)N1 Degrader C24H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-EOL5BI SCHEMBL31279486 1-[6-[[(1S,4S)-5-(2,3-dichlorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4C[C@@H]5C[C@H]4CN5C4=C(Cl)C(Cl)=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C24H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-8IIO95 SCHEMBL31279265 1-[6-[[4-(6-fluoro-1H-indol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCC(/C5=C/NC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H26FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-OFAIH5 SCHEMBL31279364 1-[6-[[4-(5-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCC(N5CCC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H28FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-JMNCLG SCHEMBL31280019 1-[6-[[4-(7-fluoroquinolin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CC=C(/C5=C/C=N\C6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C27H24FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-DOGJ1O SCHEMBL31278731 1-[6-[[4-(6-fluoro-1-methylindol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CN1/C=C(/C2=CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)C2=C1C=C(F)C=C2 Degrader C27H26FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-GOGQQ6 WO2024245444A1_05168 . O=C1CCN(N2CC3=C(/C=C\C(CN4CC(=C5CCOC6=C5C=CC(F)=C6)C4)=C/3)C2=O)C(=O)N1 Degrader C25H23FN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-4V0BZR WO2024245444A1_05169 1-[6-[[3-(5-fluoro-2,3-dihydroindol-1-yl)azetidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CC(N5CCC6=C5C=CC(F)=C6)C4)=C/3)C2=O)C(=O)N1 Degrader C24H24FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9XADFR SCHEMBL31279775 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCC(/C5=N/OC6=C5C=CC(F)=C6)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C25H22FN5O5 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-J2AUQR SCHEMBL31278944 5-[[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=NSC6=CC=CC=C65)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C24H22N6O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-V9P186 SCHEMBL31278965 5-[[4-(1-Benzothiophen-4-yl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C6C=CSC6=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C25H23N5O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-5MS2DK SCHEMBL31278896 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-[phenyl(pyridin-2-yl)methyl]piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C(C5=CC=CC=C5)C5=NC=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C29H28N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0K0SBP SCHEMBL31279485 1-[3-oxo-6-[[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(C(F)(F)F)C=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23F3N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-IJENYE SCHEMBL31278854 1-[3-oxo-6-[[4-[6-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=CC(C(F)(F)F)=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23F3N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-HT6HZQ SCHEMBL31279928 1-[3-oxo-6-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=C(C(F)(F)F)C=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23F3N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-SVN3LM WO2024245444A1_05177 . O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(N(C5=CC=CC=C5)C5=CC=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C29H28N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-ROFM7D WO2024245444A1_05178 . O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(N(C5=CC=CC=C5)C5=NC=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C28H27N7O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9JRNX4 WO2024245444A1_05179 . O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(NC5=C(C6=CC=C(CI)C=C6)C=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C31H30IN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-760NJ6 SCHEMBL31278936 5-[[4-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione CC1(C)CCC(CN2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)=C(C2=CC=C(Cl)C=C2)C1 Degrader C32H36ClN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-ZZYFRS SCHEMBL31279383 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CC=C(/C5=C/NC6=C5C=CC=N6)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C25H22N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-PKQQMX SCHEMBL31279476 5-[[4-(2,3-dichlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CC=C(C5=C(Cl)C(Cl)=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H20Cl2N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-2XGJ9Y SCHEMBL31278900 5-[[4-(2,3-Dichlorophenyl)piperidin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=C(Cl)C(Cl)=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H22Cl2N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0YLDSE SCHEMBL31278981 5-[[3-(2,3-Dichlorophenyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4C5CC4CN(C4=C(Cl)C(Cl)=CC=C4)C5)C=C3)C2=O)C(=O)N1 Degrader C24H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-YNCDEG SCHEMBL31278915 5-[[(1S,4S)-5-(2,3-dichlorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4C[C@@H]5C[C@H]4CN5C4=C(Cl)C(Cl)=CC=C4)C=C3)C2=O)C(=O)N1 Degrader C24H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-HE4ZKW SCHEMBL31278412 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN5C(=NN=C5C(F)(F)F)C4)C=C3)C2=O)C(=O)N1 Degrader C19H16F3N7O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-XCUSPJ SCHEMBL31280062 5-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC5=C(C=CS5)C4)C=C3)C2=O)C(=O)N1 Degrader C20H18N4O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-MQ8W0U SCHEMBL31279693 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(6-fluoro-1H-indol-3-yl)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCC(/C5=C/NC6=C5C=CC(F)=C6)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C26H24FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-H6FAOG SCHEMBL31279718 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(5-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCC(N5CCC6=C5C=CC(F)=C6)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C26H26FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-LS8XTN SCHEMBL31278862 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(7-fluoroquinolin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CC=C(/C5=C/C=N\C6=C5C=CC(F)=C6)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C27H22FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-S5D550 SCHEMBL31279770 5-[(4-Benzhydrylpiperazin-1-yl)methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C(C5=CC=CC=C5)C5=CC=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C30H29N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-6KNABQ SCHEMBL31279802 5-[[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione; SCHEMBL31279813 O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C(C5=CC=C(F)C=C5)C5=CC=C(F)C=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C30H27F2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-3IYJD6 SCHEMBL31279281 5-[[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C(C5=CC=C(Cl)C=C5)C5=CC=C(Cl)C=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C30H27Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-W0K16J SCHEMBL31279014 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(2-methylthieno[2,3-d]pyrimidin-4-yl)piperidin-1-yl]methyl]isoindole-1,3-dione CC1=NC(C2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)=C2C=CSC2=N1 Degrader C25H24N6O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-Q5U83R SCHEMBL31279243 5-[[4-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione CC1=C(C)C2=C(C3=CCN(CC4=C/C5=C(\C=C/4)C(=O)N(N4CCC(=O)NC4=O)C5=O)CC3)N=CN=C2S1 Degrader C26H24N6O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-G9T19D SCHEMBL31279821 5-[[(1S,4S)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4C[C@@H]5C[C@H]4CN5C(C4=CC=CC=C4)C4=CC=CC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C31H29N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-ZMO75M SCHEMBL31278984 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[(4-isoquinolin-5-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CC=C(/C5=C/C=C\C6=C5C=CN=C6)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C27H23N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-V4U2XP SCHEMBL31279000 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(6-fluoro-1-methylindol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione CN1/C=C(/C2=CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)C2=C1C=C(F)C=C2 Degrader C27H24FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-SX9PJC WO2024245444A1_05277 . O=C1CCN(N2C(=O)C3=C(/C=C(CNC45CC6CC7CC(C4)C7(C6)C5)\C=C/3)C2=O)C(=O)N1 Degrader C24H26N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-4RO0KW SCHEMBL31279966 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[3-(5-fluoro-2,3-dihydroindol-1-yl)azetidin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CC(N5CCC6=C5C=CC(F)=C6)C4)\C=C/3)C2=O)C(=O)N1 Degrader C24H22FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-Q0NCMX SCHEMBL31279157 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[(4-thieno[2,3-d]pyrimidin-4-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CC=C(C5=C6C=CSC6=NC=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C24H20N6O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-A41EVQ SCHEMBL31279203 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(6-methylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione CC1=CC2=C(C3=CCN(CC4=C/C5=C(\C=C/4)C(=O)N(N4CCC(=O)NC4=O)C5=O)CC3)N=CN=C2S1 Degrader C25H22N6O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-SBQOG2 SCHEMBL31279516 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(2-methylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione CC1=NC(C2=CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)=C2C=CSC2=N1 Degrader C25H22N6O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-EHX93D SCHEMBL31279495 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[(4-thieno[2,3-d]pyrimidin-2-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CC=C(C5=NC=C6C=CSC6=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C24H20N6O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-HBKFXG SCHEMBL31278924 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(5-methylthiophen-2-yl)piperazin-1-yl]methyl]isoindole-1,3-dione CC1=CC=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)S1 Degrader C22H23N5O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-3KI59G SCHEMBL31279256 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(5-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione CC1=CC=C(C2=CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)S1 Degrader C23H22N4O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-K5EAAB SCHEMBL31278990 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(5-methylthiophen-2-yl)piperidin-1-yl]methyl]isoindole-1,3-dione CC1=CC=C(C2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)S1 Degrader C23H24N4O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-BVND9K SCHEMBL31279372 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(5-methylthiophen-3-yl)piperazin-1-yl]methyl]isoindole-1,3-dione CC1=CC(N2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)=CS1 Degrader C22H23N5O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-97BVOS SCHEMBL31279668 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[(4-thiophen-3-ylpiperazin-1-yl)methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CSC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C21H21N5O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9UTEHV SCHEMBL31279302 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(4-methylthiophen-3-yl)piperidin-1-yl]methyl]isoindole-1,3-dione CC1=CSC=C1C1CCN(CC2=CC3=C(C=C2)C(=O)N(N2CCC(=O)NC2=O)C3=O)CC1 Degrader C23H24N4O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-HTANL0 SCHEMBL31279810 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(furan-2-yl)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=CC=CO5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H22N4O5 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-06OPWL SCHEMBL31278810 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(4-methylthiophen-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione CC1=CSC=C1C1=CCN(CC2=CC3=C(C=C2)C(=O)N(N2CCC(=O)NC2=O)C3=O)CC1 Degrader C23H22N4O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-AQ16JT SCHEMBL31278570 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(furan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CC=C(C5=CC=CO5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H20N4O5 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-4Q3VAR SCHEMBL31279078 5-[[4-(5-Chloropyridin-2-yl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=C(Cl)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H21ClN6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-AEP1AT SCHEMBL31278492 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[(4-pyridin-2-ylpiperazin-1-yl)methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=CC=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H22N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-OQ3A08 SCHEMBL31279664 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(6-methylpyridin-2-yl)piperazin-1-yl]methyl]isoindole-1,3-dione CC1=NC(N2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)=CC=C1 Degrader C23H24N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9T20HL SCHEMBL31278974 5-[[4-(6-Chloropyridin-2-yl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=CC(Cl)=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H21ClN6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-X6P0FZ SCHEMBL31279519 5-[[4-(4-Chloropyridin-2-yl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC(Cl)=CC=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H21ClN6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-NTMNN2 SCHEMBL31279074 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(3-fluoropyridin-2-yl)piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(F)C=CC=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H21FN6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-5LM1B3 SCHEMBL31279105 1-[6-[[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(Cl)C=C(Cl)C=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22Cl2N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-PEL2PO SCHEMBL31279167 1-[6-[[4-(3,4-difluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(F)C(F)=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22F2N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-Q9BVRX SCHEMBL31278473 1-[6-[[4-(4-chloro-3-fluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(F)C(Cl)=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22ClFN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0PEKQ9 SCHEMBL31279267 1-[6-[[4-(3-fluoro-4-iodopyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(F)C(I)=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22FIN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-T09755 SCHEMBL31279349 1-[6-[[4-(3-bromo-4-chloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(Br)C(Cl)=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22BrClN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-6RT7K1 SCHEMBL31279845 1-[6-[[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(Cl)C=C(C(F)(F)F)C=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H22ClF3N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-O1RHUF SCHEMBL31279559 1-[3-oxo-6-[(4-pyridin-3-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=CN=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H24N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-7E3FUR SCHEMBL31279181 1-[6-[[4-(6-chloropyridin-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=C(Cl)N=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23ClN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-IL0PPI WO2024245444A1_05436 . O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(Cl)C(Cl)=CN=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22Cl2N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-UE483M SCHEMBL31279222 1-[3-oxo-6-[(4-pyridin-4-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=NC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H24N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-DDTF7C SCHEMBL31278714 1-[6-[[4-(2-methylpyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CC(N2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)=CC=N1 Degrader C23H26N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-SZ8XAK SCHEMBL31279289 1-[6-[[4-(3-bromopyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=NC=C5Br)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23BrN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CWR9JA SCHEMBL31280331 1-[6-[[4-(3-fluoropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=NC=C5F)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23FN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0DWCJS SCHEMBL31279168 1-[6-[[4-(3-chloropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=NC=C5Cl)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23ClN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-H11PBU SCHEMBL31279445 1-[6-[[4-(2-chloropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CC=NC(Cl)=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H23ClN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-WQ99V4 SCHEMBL31279240 4-[4-[[4-[[2-(2,4-dioxo-1,3-diazinan-1-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile N#CC1=CC(F)=C(N2CCN(CC3=CC=C(CO/C4=C/C=C\C5=C4CN(N4CCC(=O)NC4=O)C5=O)C=C3)CC2)C=C1 Degrader C31H29FN6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CB9ENX SCHEMBL31279268 1-[3-oxo-6-[[4-[phenyl(pyridin-3-yl)methyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C(C5=CC=CC=C5)C5=CN=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C29H30N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-U1YEV4 SCHEMBL31278666 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-[phenyl(pyridin-3-yl)methyl]piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C(C5=CC=CC=C5)C5=CN=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C29H28N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-IIE4PB SCHEMBL31278925 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-[phenyl(pyridin-4-yl)methyl]piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C(C5=CC=CC=C5)C5=CC=NC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C29H28N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-1Y1UEM SCHEMBL31279015 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(dipyridin-2-ylmethyl)piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C(C5=CC=CC=N5)C5=NC=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C28H27N7O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-69O50S SCHEMBL31279311 1-[6-[(3-benzhydryl-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4C5CC4CN(C(C4=CC=CC=C4)C4=CC=CC=C4)C5)=C/3)C2=O)C(=O)N1 Degrader C31H31N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-I0W2HW SCHEMBL31279111 5-[(3-Benzhydryl-3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4C5CC4CN(C(C4=CC=CC=C4)C4=CC=CC=C4)C5)\C=C/3)C2=O)C(=O)N1 Degrader C31H29N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-JDCDZJ SCHEMBL31278964 1-[6-[[(1R,4R)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4C[C@H]5C[C@@H]4CN5C(C4=CC=CC=C4)C4=CC=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C31H31N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-RTAFPJ SCHEMBL31279839 5-[[(1R,4R)-5-benzhydryl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4C[C@H]5C[C@@H]4CN5C(C4=CC=CC=C4)C4=CC=CC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C31H29N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0W8G15 SCHEMBL31279192 1-[6-[(4-benzhydryl-3,3-dimethylpiperazin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1(C)CN(CC2=C/C3=C(\C=C/2)C(=O)N(N2CCC(=O)NC2=O)C3)CCN1C(C1=CC=CC=C1)C1=CC=CC=C1 Degrader C32H35N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-MJQC9J SCHEMBL31279417 5-[(4-Benzhydryl-3,3-dimethylpiperazin-1-yl)methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione CC1(C)CN(CC2=C/C3=C(\C=C/2)C(=O)N(N2CCC(=O)NC2=O)C3=O)CCN1C(C1=CC=CC=C1)C1=CC=CC=C1 Degrader C32H33N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CNV5I3 SCHEMBL31278521 1-[6-[[4-(3,4-dichloropyridin-2-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=C(Cl)C(Cl)=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-FDY6VE SCHEMBL31278648 5-[[4-(3,4-Dichloropyridin-2-yl)piperidin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=C(Cl)C(Cl)=CC=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-KHNY9Z SCHEMBL31279601 1-[6-[[4-(2,3-dichloropyridin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=C(Cl)C(Cl)=NC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-4MFXIN SCHEMBL31279040 5-[[4-(2,3-Dichloropyridin-4-yl)piperidin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=C(Cl)C(Cl)=NC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-JWQOI4 SCHEMBL31279283 1-[6-[[4-(3,4-dichloropyridin-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CC=C(C5=C(Cl)C(Cl)=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-8F4Y0G SCHEMBL31280365 1-[6-[[4-(4,5-dichloropyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CC=C(C5=C(Cl)C(Cl)=CN=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-P2JO0N SCHEMBL31279785 1-[6-[[4-(5-chloropyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CC=C(C5=CC(Cl)=CN=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H22ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-Q6RIVZ SCHEMBL31279797 1-[6-[[4-(3-fluoropyridin-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CC=C(C5=C(F)C=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H22FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-MREBYF SCHEMBL31279898 1-[6-[[4-(2,3-difluoropyridin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=C(F)C(F)=NC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-NY395W SCHEMBL31279571 1-[6-[[4-(2,3-difluoropyridin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CC=C(C5=C(F)C(F)=NC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H21F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-98HJSD SCHEMBL31279108 5-[(4-Benzhydryl-3,5-dimethylpiperazin-1-yl)methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione CC1CN(CC2=C/C3=C(\C=C/2)C(=O)N(N2CCC(=O)NC2=O)C3=O)CC(C)N1C(C1=CC=CC=C1)C1=CC=CC=C1 Degrader C32H33N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-U1EB3T SCHEMBL31279544 1-[6-[(4-benzhydryl-3,5-dimethylpiperazin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1CN(CC2=C/C3=C(\C=C/2)C(=O)N(N2CCC(=O)NC2=O)C3)CC(C)N1C(C1=CC=CC=C1)C1=CC=CC=C1 Degrader C32H35N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-LZUE4Y SCHEMBL31279655 5-[[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(CC5=C(C6=CC=C(Cl)C=C6)C=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C30H28ClN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9DDSCK SCHEMBL31279195 1-[6-[[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(CC5=C(C6=CC=C(Cl)C=C6)C=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C30H30ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-FOZLVN SCHEMBL31279389 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[[4-(3-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione CC1=C(C2=CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)SC=C1 Degrader C23H22N4O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-XXFVVN SCHEMBL31279432 2-(2,4-dioxo-1,3-diazinan-1-yl)-5-[(4-thiophen-3-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CC=C(C5=CSC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H20N4O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-YGNW52 SCHEMBL31279102 1-[6-[[(2R)-4-benzhydryl-2-methylpiperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione C[C@@H]1CN(C(C2=CC=CC=C2)C2=CC=CC=C2)CCN1CC1=C/C2=C(\C=C/1)C(=O)N(N1CCC(=O)NC1=O)C2 Degrader C31H33N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-OLVKOX SCHEMBL31279248 5-[[(2R)-4-benzhydryl-2-methylpiperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione C[C@@H]1CN(C(C2=CC=CC=C2)C2=CC=CC=C2)CCN1CC1=C/C2=C(\C=C/1)C(=O)N(N1CCC(=O)NC1=O)C2=O Degrader C31H31N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9KCP54 SCHEMBL31279257 1-[6-[(5-benzhydryl-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CC5CCC4CN5C(C4=CC=CC=C4)C4=CC=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C32H33N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-C8UFEY SCHEMBL31279360 5-[(5-Benzhydryl-2,5-diazabicyclo[2.2.2]octan-2-yl)methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CC5CCC4CN5C(C4=CC=CC=C4)C4=CC=CC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H31N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CNBGA7 SCHEMBL31278554 1-[6-[(8-benzhydryl-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CC5CCC(C4)N5C(C4=CC=CC=C4)C4=CC=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C32H33N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-PXQFCU SCHEMBL31279227 5-[(8-Benzhydryl-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CC5CCC(C4)N5C(C4=CC=CC=C4)C4=CC=CC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H31N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0VZLJA SCHEMBL31278593 1-[6-[(3-benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4C5CCC4CN(C(C4=CC=CC=C4)C4=CC=CC=C4)C5)=C/3)C2=O)C(=O)N1 Degrader C32H33N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-OKC29Z SCHEMBL31279677 5-[(3-Benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4C5CCC4CN(C(C4=CC=CC=C4)C4=CC=CC=C4)C5)\C=C/3)C2=O)C(=O)N1 Degrader C32H31N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9YX9V9 SCHEMBL31279670 1-[6-[[3-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1(C)CCC(CN2CC3CC(C2)N3CC2=C/C3=C(\C=C/2)C(=O)N(N2CCC(=O)NC2=O)C3)=C(C2=CC=C(Cl)C=C2)C1 Degrader C33H38ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-4H2GZG SCHEMBL31279009 5-[[3-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione CC1(C)CCC(CN2CC3CC(C2)N3CC2=C/C3=C(\C=C/2)C(=O)N(N2CCC(=O)NC2=O)C3=O)=C(C2=CC=C(Cl)C=C2)C1 Degrader C33H36ClN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0QUIG3 SCHEMBL31279163 1-[6-[[6-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1(C)CCC(CN2C3CC2CN(CC2=C/C4=C(\C=C/2)C(=O)N(N2CCC(=O)NC2=O)C4)C3)=C(C2=CC=C(Cl)C=C2)C1 Degrader C33H38ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-7ZBP2N SCHEMBL31280169 5-[[6-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione CC1(C)CCC(CN2C3CC2CN(CC2=C/C4=C(\C=C/2)C(=O)N(N2CCC(=O)NC2=O)C4=O)C3)=C(C2=CC=C(Cl)C=C2)C1 Degrader C33H36ClN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-OC3SJ4 SCHEMBL31278962 1-[3-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H25N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-N4SODM SCHEMBL31279254 1-[6-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione COC1=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)C=CC=C1 Degrader C24H27N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-2KPKJP SCHEMBL31279650 1-[6-[[4-(3-bromophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC(Br)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24BrN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CUYTUM SCHEMBL31279434 1-[6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione COC1=CC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)=CC=C1 Degrader C24H27N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-ERSV5H SCHEMBL31279717 1-[3-oxo-6-[[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(C(F)(F)F)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F3N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-O9VE5G SCHEMBL31279276 1-[6-[[4-(3-fluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC(F)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-3LBR3Q SCHEMBL31279036 1-[6-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(F)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-3PII47 SCHEMBL31279425 1-[6-[[4-(2-chlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-RBGEQW SCHEMBL31279330 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[(4-phenylpiperazin-1-yl)methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=CC=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H23N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-G5HCQ4 SCHEMBL31279120 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]isoindole-1,3-dione COC1=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)C=CC=C1 Degrader C24H25N5O5 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-F7Y9RO SCHEMBL31279110 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]isoindole-1,3-dione COC1=CC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)=CC=C1 Degrader C24H25N5O5 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-3ZQX01 SCHEMBL31279079 5-[[4-(3-Bromophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=CC=CC(Br)=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H22BrN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-7L9OUX SCHEMBL31279586 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=CC=C(C(F)(F)F)C=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C24H22F3N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-X5EK56 SCHEMBL31279378 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(3-fluorophenyl)piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=CC=CC(F)=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H22FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-TCUZVN SCHEMBL31278930 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=CC=C(F)C=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H22FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CT5IIU SCHEMBL31279066 5-[[4-(2-Chlorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=C(Cl)C=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H22ClN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-6UA457 SCHEMBL31279285 5-[[4-(2-Bromophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=C(Br)C=CC=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H22BrN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-82GKD8 SCHEMBL31279218 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]isoindole-1,3-dione COC1=CC=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)C=C1 Degrader C24H25N5O5 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-T0HC81 SCHEMBL31279473 1-[6-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(Cl)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-4QZO6G SCHEMBL31279201 1-[6-[[4-(2-bromophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C(Br)C=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24BrN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-WPNIOX SCHEMBL31279439 1-[6-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione COC1=CC=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)C=C1 Degrader C24H27N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-77H3AM SCHEMBL31278478 1-[6-[[4-(4-bromophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(Br)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24BrN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-7P2GTB SCHEMBL31279160 1-[6-[[4-(2-methylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)C=CC=C1 Degrader C24H27N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-3PP3O9 SCHEMBL31280003 1-[6-[[4-(3-methylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)=CC=C1 Degrader C24H27N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-RI4US1 SCHEMBL31279730 1-[6-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CC=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)C=C1 Degrader C24H27N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-IQSF9V SCHEMBL31279953 1-[6-[[4-(2,4-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=C(Cl)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-ARBYZX SCHEMBL31279238 1-[6-[[4-(2,5-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=CC(Cl)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0ZT55V SCHEMBL31279188 1-[6-[[4-(2,6-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=CC=C5Cl)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-JFKYX6 SCHEMBL31279442 1-[6-[[4-(3,4-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(Cl)C(Cl)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-XGGA99 SCHEMBL31279007 1-[6-[[4-(3,5-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC(Cl)=CC(Cl)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-96AM6B SCHEMBL31279816 1-[6-[[4-(2,3-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C(F)=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-8NKHA7 SCHEMBL31279517 1-[6-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C=C(F)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-U9QOY4 SCHEMBL31279034 1-[6-[[4-(2,5-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C=CC(F)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-OH8CZ7 SCHEMBL31279515 1-[6-[[4-(2,6-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C=CC=C5F)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-87B3TA SCHEMBL31279246 1-[6-[[4-(3,4-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(F)C(F)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-4CUQBZ SCHEMBL31279803 1-[6-[[4-(3,5-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(/C=C\C(CN4CCN(C5=CC(F)=CC(F)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-U1OVY2 SCHEMBL31279031 5-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=CC=C(Cl)C=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H22ClN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-25NDYS SCHEMBL31278803 5-[[4-(4-Bromophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=CC=C(Br)C=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H22BrN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-KTCD25 SCHEMBL31278906 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(2-methylphenyl)piperazin-1-yl]methyl]isoindole-1,3-dione CC1=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)C=CC=C1 Degrader C24H25N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-77MKJI SCHEMBL31280334 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(3-methylphenyl)piperazin-1-yl]methyl]isoindole-1,3-dione CC1=CC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)=CC=C1 Degrader C24H25N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-82K2H0 SCHEMBL31279139 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(4-methylphenyl)piperazin-1-yl]methyl]isoindole-1,3-dione CC1=CC=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)C=C1 Degrader C24H25N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-3H1BXU SCHEMBL31279117 5-[[4-(2,4-Dichlorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=C(Cl)C=C(Cl)C=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-P6E0YD SCHEMBL31279328 5-[[4-(2,5-Dichlorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=C(Cl)C=CC(Cl)=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-NE3MUP SCHEMBL31279116 5-[[4-(2,6-Dichlorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(/C=C(CN4CCN(C5=C(Cl)C=CC=C5Cl)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-R1GPUW SCHEMBL31278948 5-[[4-(3,4-Dichlorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=C(Cl)C(Cl)=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-99QR2F SCHEMBL31278951 5-[[4-(3,5-Dichlorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC(Cl)=CC(Cl)=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21Cl2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-8E81Y8 SCHEMBL31279521 5-[[4-(2,3-Difluorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(F)C(F)=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21F2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CEQBYX SCHEMBL31279210 5-[[4-(2,4-Difluorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(F)C=C(F)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21F2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-NG7W2K SCHEMBL31278850 5-[[4-(2,5-Difluorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(F)C=CC(F)=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21F2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-TNWTL9 SCHEMBL31279375 5-[[4-(2,6-Difluorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(F)C=CC=C5F)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21F2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-NBZYBC SCHEMBL31279863 5-[[4-(3,4-Difluorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=C(F)C(F)=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21F2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-Y6R9G6 SCHEMBL31279758 5-[[4-(3,5-Difluorophenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC(F)=CC(F)=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21F2N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-TGJWTH SCHEMBL31279703 5-[[4-(2,4-Dimethylphenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione CC1=CC(C)=C(N2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)C=C1 Degrader C25H27N5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-LCUFVX SCHEMBL31278935 5-[[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione CC1=C(N2CCN(CC3=CC4=C(C=C3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)C=C(Cl)C=C1 Degrader C24H24ClN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-303DKS SCHEMBL31279686 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[(4-phenylpiperidin-1-yl)methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=CC=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H24N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-12B1MY SCHEMBL31280130 5-[[4-(3-Bromophenyl)piperidin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=CC=CC(Br)=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H23BrN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9BF5GR SCHEMBL31279464 5-[[4-(4-Bromophenyl)piperidin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=CC=C(Br)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H23BrN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-EZBRRV SCHEMBL31278945 5-[[4-(2-Chlorophenyl)piperidin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=C(Cl)C=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H23ClN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-74EI7F SCHEMBL31279416 5-[[4-(4-Chlorophenyl)piperidin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=CC=C(Cl)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H23ClN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-G1FQM0 SCHEMBL31279095 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(2-fluorophenyl)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=C(F)C=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H23FN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-PONNO8 SCHEMBL31279379 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(4-fluorophenyl)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=CC=C(F)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H23FN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-TRVWIQ SCHEMBL31279848 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-[2-(trifluoromethyl)phenyl]piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=C(C(F)(F)F)C=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C25H23F3N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-IER1JT SCHEMBL31279170 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=CC=CC(C(F)(F)F)=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C25H23F3N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9UZWUW SCHEMBL31279829 1-[6-[[4-(2,4-dimethylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=CC(C)=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)C=C1 Degrader C25H29N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-4MWH69 SCHEMBL31279093 1-[6-[[4-(5-chloro-2-methylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione CC1=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(N3CCC(=O)NC3=O)C4)CC2)C=C(Cl)C=C1 Degrader C24H26ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-ZTMSMG SCHEMBL31278765 1-[3-oxo-6-[(4-phenylpiperidin-1-yl)methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=CC=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H26N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-1U4VHB SCHEMBL31278994 1-[6-[[4-(3-bromophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=CC=CC(Br)=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H25BrN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-JNY2BJ SCHEMBL31279665 1-[6-[[4-(4-bromophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=CC=C(Br)C=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H25BrN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-MAXBTD SCHEMBL31279502 1-[6-[[4-(2-chlorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=C(Cl)C=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H25ClN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CUMKUN SCHEMBL31278470 1-[6-[[4-(4-chlorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=CC=C(Cl)C=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H25ClN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-FGY037 SCHEMBL31279215 1-[6-[[4-(2-fluorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=C(F)C=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H25FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-1UE38J SCHEMBL31279073 1-[6-[[4-(4-fluorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=CC=C(F)C=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H25FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-LI07SY SCHEMBL31279642 1-[3-oxo-6-[[4-[2-(trifluoromethyl)phenyl]piperidin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=C(C(F)(F)F)C=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C25H25F3N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-YDJC71 SCHEMBL31279198 1-[3-oxo-6-[[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=CC=CC(C(F)(F)F)=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C25H25F3N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-DT6ZXF SCHEMBL31279504 1-[6-[[4-(2,3-dichlorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=C(Cl)C(Cl)=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-4TOOQH SCHEMBL31278895 1-[6-[[4-(2-chloro-3-fluorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCC(C5=C(Cl)C(F)=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H24ClFN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-XOET08 SCHEMBL31279931 5-[[4-(2-Chloro-3-fluorophenyl)piperidin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=C(Cl)C(F)=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H22ClFN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-HEDU9M SCHEMBL31279600 5-[[4-(2-chloro-3-fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CC=C(C5=C(Cl)C(F)=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H20ClFN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-CJLE6S SCHEMBL31279376 5-[[4-(2,3-Difluorophenyl)piperidin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCC(C5=C(F)C(F)=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C24H22F2N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-UIFJ8L SCHEMBL31278871 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(6-fluoropyridin-2-yl)piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=CC(F)=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H21FN6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-KUE1D1 SCHEMBL31279226 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(5-fluoropyridin-2-yl)piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=C(F)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H21FN6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-QHSEN1 SCHEMBL31279197 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(C(F)(F)F)C=CC=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21F3N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-9ROWSY US20240425475, Compound GT-03301 3-[5-[2-[4-[2-(1-Adamantyl)ethyl]piperazin-1-yl]ethylamino]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; BDBM708507; US20240425475, Compound GT-03301; 3-(5-((2-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)piperazin- 1-yl)ethyl)amino)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione Cc1nc2cccc(NCCN3CCN(CCC45CC6CC(CC(C6)C4)C5)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C32H44N6O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-43K3DC SCHEMBL31279490 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-[6-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=CC(C(F)(F)F)=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21F3N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-6895HW SCHEMBL31279932 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=C(C(F)(F)F)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H21F3N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-HDR8DR US20240425475, Compound GT-03306 3-[5-[3-[4-[2-(1-Adamantyl)ethyl]piperazin-1-yl]propylsulfanyl]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25345891; BDBM708493; US20240425475, Compound GT-03306; 3-(5-((3-(4-(2-((3r, 5r,7r)-adamantan-1- yl)ethyl)piperazin- 1-yl)propyl)thio)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione Cc1nc2cccc(SCCCN3CCN(CCC45CC6CC(CC(C6)C4)C5)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C33H45N5O3S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-H1TDEI SCHEMBL31279756 5-[[4-(3,5-Dichloropyridin-2-yl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(Cl)C=C(Cl)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H20Cl2N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-XJSI4D SCHEMBL31279358 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[[4-(3-fluoro-4-iodopyridin-2-yl)piperazin-1-yl]methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(F)C(I)=CC=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H20FIN6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-GARKTL SCHEMBL31278669 2-(2,4-Dioxo-1,3-diazinan-1-yl)-5-[(4-pyridin-3-ylpiperazin-1-yl)methyl]isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=CN=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H22N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-DNH2LR SCHEMBL31279740 5-[[4-(4,5-Dichloropyridin-3-yl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(Cl)C(Cl)=CN=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H20Cl2N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-5I3NDO SCHEMBL31278967 5-[[4-(2,4-Dichloropyridin-3-yl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(Cl)C=CN=C5Cl)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H20Cl2N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-HDNWAO SCHEMBL31280244 1-[6-[[4-(2,4-dichloropyridin-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(Cl)C=CN=C5Cl)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22Cl2N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-K7152M SCHEMBL31279669 5-[[4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=C(Cl)C=C(C(F)(F)F)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C23H20ClF3N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-IIC4TR SCHEMBL31279489 5-[[4-(6-Chloropyridin-3-yl)piperazin-1-yl]methyl]-2-(2,4-dioxo-1,3-diazinan-1-yl)isoindole-1,3-dione O=C1CCN(N2C(=O)C3=C(C=C(CN4CCN(C5=CC=C(Cl)N=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C22H21ClN6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-3OJJW6 SCHEMBL31279743 1-[6-[[4-(5,6-dichloropyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=NC=NC(Cl)=C5Cl)CC4)=C3)C2=O)C(=O)N1 Degrader C21H21Cl2N7O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-GSEAJ9 SCHEMBL31278518 1-[6-[[4-(5,6-dichloropyridazin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=CN=NC(Cl)=C5Cl)CC4)=C3)C2=O)C(=O)N1 Degrader C21H21Cl2N7O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0QJ2ZP SCHEMBL31278883 1-[6-[[4-(3,6-dichloropyridazin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(Cl)N=NC(Cl)=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C21H21Cl2N7O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-FVOWPZ SCHEMBL31279390 1-[3-oxo-6-[[4-(1,3,5-triazin-2-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=NC=NC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C20H22N8O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-0JIF10 SCHEMBL25343421 3-[5-[3-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]propylsulfanyl]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25343421 Cc1nc2cccc(SCCCN3CCN(C(c4ccc(F)cc4)c4ccc(F)cc4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C34H35F2N5O3S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-JX74IF SCHEMBL31279211 1-[6-[[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]-1,3-diazinane-2,4-dione O=C1CCN(N2CC3=C(C=CC(CN4CCN(C5=C(Cl)C=NC=C5Cl)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22Cl2N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2024245444-A1 TPD-AJU5HD SCHEMBL25345092 3-[8-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethylamino]-3-methyl-1-oxoisoquinolin-2-yl]piperidine-2,6-dione\; SCHEMBL25345092 Cc1cc2cccc(NCCN3CCN(C(c4ccc(F)cc4)c4ccc(F)cc4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C34H35F2N5O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-7N1025 SCHEMBL31337989 3-[6-[[4-[[4-(1-adamantyl)phenyl]methyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(CC5=CC=C(C67CC8CC(CC(C8)C6)C7)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C35H42N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-U5VGPT SCHEMBL31338138 3-[3-oxo-6-[[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN5C(=NN=C5C(F)(F)F)C4)=C3)C2=O)C(=O)N1 Degrader C20H19F3N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-P68ZDC SCHEMBL25345577 3-[5-[3-[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]propylsulfanyl]-2-methyl-4-oxoquinazolin-3-yl]piperidine-2,6-dione\; SCHEMBL25345577 Cc1nc2cccc(SCCCN3CCN(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)CC3)c2c(=O)n1C1CCC(=O)NC1=O Degrader C34H35Cl2N5O3S IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2023151635-A1 TPD-ESESWH SCHEMBL31338409 3-[6-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC5=C(C=CS5)C4)=C/3)C2=O)C(=O)N1 Degrader C21H21N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-DGK6M9 SCHEMBL31338219 3-[6-[[4-(2,3-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C(Cl)=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-5XAALX SCHEMBL31337984 3-[6-[[4-(1-benzothiophen-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(/C5=C/C=C\C6=C5C=CS6)CC4)=C3)C2=O)C(=O)N1 Degrader C26H26N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-X0PWQP SCHEMBL31338236 3-[6-[[4-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC=C(SC2=C(N3CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)C=CC=C2)C(C)=C1 Degrader C32H34N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-RDB6ER SCHEMBL31338027 3-[6-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(/C5=N/OC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H25FN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-T6OSGN SCHEMBL31338261 3-[6-[[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=NSC6=CC=CC=C65)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-T78R4K SCHEMBL31338084 3-[6-[[4-(3-chloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-LWEP3Q SCHEMBL31338330 3-[6-[[4-(4-chloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC(Cl)=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-QHYM7Q SCHEMBL31338053 3-[6-[[4-(5-chloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(Cl)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-8YPO9C SCHEMBL31338158 3-[3-oxo-6-[[4-[6-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC(C(F)(F)F)=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F3N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-EA6KKR SCHEMBL31338174 3-[3-oxo-6-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(C(F)(F)F)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F3N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-4UJ2TJ SCHEMBL31338078 3-[3-oxo-6-[[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(C(F)(F)F)C=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F3N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-T7O54Z SCHEMBL31338088 3-[6-[[4-(2-chloropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC(Cl)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-P0EOS2 SCHEMBL31338038 3-[6-[[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=NC=C5Cl)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-UA4LNK SCHEMBL31338135 3-[6-[[4-(3,4-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(C5=CC=C(Cl)C(Cl)=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-261DWQ SCHEMBL31338187 3-[6-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C=C(F)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-A50CS0 SCHEMBL31338244 3-[6-[[4-(2,4-dimethylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC(C)=C(N2CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)C=C1 Degrader C26H30N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-A3EJ8F SCHEMBL31338267 3-[6-[[4-(5-chloro-2-methylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(N2CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)C=C(Cl)C=C1 Degrader C25H27ClN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-6LD0I1 SCHEMBL31338320 3-[6-[[4-(2,3-dichlorophenyl)piperazin-1-yl]methyl]-4-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C2=O)/C(F)=C\C(CN2CCN(C4=C(Cl)C(Cl)=CC=C4)CC2)=C/3)C(=O)N1 Degrader C24H23Cl2FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-UEBV5L SCHEMBL25236187 3-[3-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL31076835 O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H26N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-Z9FFEZ SCHEMBL31338389 3-[6-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC1=CC=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)C=C1 Degrader C25H28N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-Q0R2ZC SCHEMBL31338385 3-[6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC1=CC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=CC=C1 Degrader C25H28N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-46B52Z SCHEMBL31338145 3-[3-oxo-6-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H25N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-9MXOVM SCHEMBL31338308 3-[3-oxo-6-[(4-pyridin-4-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H25N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-PDZI92 SCHEMBL31338273 3-[3-oxo-6-[[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(C(F)(F)F)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H25F3N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-VVPEWF SCHEMBL31338010 3-[6-[[4-(3-fluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC(F)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H25FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-1TS0NP SCHEMBL31337945 3-[6-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(F)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H25FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-XEEYBI SCHEMBL31338221 3-[6-[[4-(2-chlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H25ClN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-3VPEXG SCHEMBL31338231 3-[6-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(Cl)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H25ClN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-Q7HW45 SCHEMBL31338242 3-[6-[[4-(2-bromophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Br)C=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H25BrN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-Q24CCD SCHEMBL31338005 3-[6-[[4-(2-methylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)C=CC=C1 Degrader C25H28N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-4EZYIA SCHEMBL31338016 3-[6-[[4-(3-methylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=CC=C1 Degrader C25H28N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-UGWULZ SCHEMBL31338224 3-[6-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)C=C1 Degrader C25H28N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-C2IJ68 SCHEMBL31338007 3-[6-[[4-(2,4-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=C(Cl)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-VF0I1E SCHEMBL31338031 3-[3-oxo-6-[(4-phenylpiperidin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCC(C5=CC=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C25H27N3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-5BBMDT SCHEMBL31338200 3-[6-[[4-(3-bromophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCC(C5=CC=CC(Br)=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C25H26BrN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-9FFMGU SCHEMBL31338377 3-[6-[[4-(3-bromophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC(Br)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H25BrN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-86DZC3 SCHEMBL31338090 3-[6-[[4-(2-chlorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C(Cl)C=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H26ClN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-ZC9RJX SCHEMBL31338188 3-[6-[[4-(4-chlorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=CC=C(Cl)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H26ClN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-Z7LMA1 SCHEMBL31338309 3-[6-[[4-(2-fluorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C(F)C=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H26FN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-IYQZTE SCHEMBL31338019 3-[6-[[4-(4-fluorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=CC=C(F)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H26FN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-YNYH3W SCHEMBL31338018 3-[3-oxo-6-[[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=CC=CC(C(F)(F)F)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H26F3N3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-RJMYFB SCHEMBL25226548 3-[3-oxo-6-[(4-pyridazin-3-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL31077524 O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=NN=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C22H24N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-7T100N SCHEMBL31338365 3-[6-[[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=C(Cl)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-42MYCY SCHEMBL31337952 3-[6-[[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=C(C(F)(F)F)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H23ClF3N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-VPX4H5 SCHEMBL31338260 3-[6-[[4-(3-chloropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC=C5Cl)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-F0U53B SCHEMBL25647384 3-[6-[[4-(6-chloropyridazin-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL31076539 O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=NN=C(Cl)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C22H23ClN6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-TZSWWW SCHEMBL31338255 3-[3-oxo-6-[(4-pyrazin-2-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=NC=CN=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C22H24N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-FWG8HO SCHEMBL31338230 3-[3-oxo-6-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=NC=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C22H24N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-DKJ4PJ SCHEMBL25230219 3-[6-[[4-(4-bromophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(Br)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H25BrN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-N4PRD6 SCHEMBL31338324 3-[3-oxo-6-[[4-(1,3,5-triazin-2-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=NC=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C21H23N7O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-XCTCV9 WO2025016359A1_04487 . O=C1C=CC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=CC(Cl)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H22Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-6UHQBC SCHEMBL31338134 3-[3-oxo-6-[[4-[2-(trifluoromethyl)phenyl]piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C(C(F)(F)F)C=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H26F3N3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-BPCEXQ SCHEMBL31338215 3-[6-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC1=C(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)C=CC=C1 Degrader C25H28N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-ASU6WY SCHEMBL31338332 3-[6-[[4-(4-chloro-6-methylpyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=CC(Cl)=C1 Degrader C24H26ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-DHC957 SCHEMBL31338287 3-[6-[[4-(2,6-dimethylpyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=CC(C)=N1 Degrader C25H29N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-9HYF0L SCHEMBL31338154 3-[6-[[4-(4-bromophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=CC=C(Br)C=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H26BrN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-9M4EVY SCHEMBL31338316 3-[3-oxo-6-[(4-thiophen-2-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=CC=CS5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-VCS18D SCHEMBL31338117 3-[6-[[4-(3-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(C2=CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)SC=C1 Degrader C24H25N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-QM9IFR SCHEMBL31338085 3-[6-[[4-(3,5-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(C5=CC(F)=CC(F)=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H24F2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-1ZW5LF SCHEMBL31338334 3-[6-[[4-(6-chloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC(Cl)=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-R0UV2X SCHEMBL31338352 3-[6-[[4-(6-fluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CC(F)=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-YFJF4S SCHEMBL31338043 3-[3-oxo-6-[[4-(2,3,5,6-tetrafluoropyridin-4-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C(F)=NC(F)=C5F)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H21F4N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-5Q7R7I SCHEMBL31338326 3-[6-[[4-(3,6-dichloropyridazin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)N=NC(Cl)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C22H22Cl2N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-11HEXM SCHEMBL31338210 3-[6-[[4-(5,6-dichloropyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=NC=NC(Cl)=C5Cl)CC4)=C/3)C2=O)C(=O)N1 Degrader C22H22Cl2N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-SOE3UI SCHEMBL31337953 3-[6-[[4-(3-methylthiophen-2-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(C2CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)SC=C1 Degrader C24H27N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-ZRRDQV SCHEMBL31338058 3-[6-[[4-(4-methylthiophen-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CSC=C1C1=CCN(CC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)CC1 Degrader C24H25N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-CPBZ6R SCHEMBL31338081 3-[6-[[4-(4-methylthiophen-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CSC=C1C1CCN(CC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)CC1 Degrader C24H27N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-KBBN2J SCHEMBL31338097 3-[3-oxo-6-[(4-pyridin-3-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=CN=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H25N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-HPAVZI SCHEMBL31338026 3-[6-[[4-(2,3-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C(F)=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-MDYB3J SCHEMBL31338061 3-[6-[[4-(2,3-dichlorophenyl)piperazin-1-yl]methyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C(Cl)=CC=C5)CC4)=C/3F)C2=O)C(=O)N1 Degrader C24H23Cl2FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-ZY6CB7 SCHEMBL31338253 3-[6-[[4-(2,3-dichlorophenyl)piperazin-1-yl]methyl]-5-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C(F)\C(CN4CCN(C5=C(Cl)C(Cl)=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H23Cl2FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-YD77SS SCHEMBL31338076 3-[7-[[4-(2,3-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC=C3CN3CCN(C4=C(Cl)C(Cl)=CC=C4)CC3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-7POHLJ SCHEMBL31337936 3-[6-[[4-(3,4-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(F)C(F)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-K2A11O SCHEMBL31338403 3-[6-[[4-(6-methylpyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=CC=C1 Degrader C24H27N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-Q5I9GE SCHEMBL31338113 3-[6-[[4-(5-fluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(F)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-4PHSFY SCHEMBL31338006 3-[6-[[4-(3,4-dichloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C(Cl)=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-JGJ18X SCHEMBL31338045 3-[6-[[4-(4,5-dichloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC(Cl)=C(Cl)C=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-UUYCTL SCHEMBL31338412 3-[6-[[4-(6-chloropyridin-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=C(Cl)N=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24ClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-NXTZ5K SCHEMBL31338227 3-[6-[[4-(4,5-dichloropyridin-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C(Cl)=CN=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-1Z1KFC SCHEMBL31338362 3-[6-[[4-(2,5-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C=CC(F)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-A3R1OB SCHEMBL31338030 3-[6-[[4-(2,6-difluorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C=CC=C5F)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-W12RG6 SCHEMBL31338281 3-[6-[[4-(2-methylpyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=CC=N1 Degrader C24H27N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-28MHGK SCHEMBL31338247 3-[6-[[4-(2,3-dichloropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC(Cl)=C5Cl)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-8TXF0Q SCHEMBL31338289 3-[6-[[4-(2,3-difluoropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC(F)=C5F)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-K9O1ZR SCHEMBL31338349 3-[6-[[4-(5,6-dichloropyridazin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(C5=C(Cl)C(Cl)=NN=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H22Cl2N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-MGZU1G SCHEMBL31338299 3-[3-oxo-6-[(4-thiophen-3-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(C5=CSC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H24N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-BJ8JQS SCHEMBL31338241 3-[6-[[4-(4-methylthiophen-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CSC=C1N1CCN(CC2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3)CC1 Degrader C23H26N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-L5CKTA SCHEMBL31338234 3-[6-[[4-(5-methylthiophen-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC(N2CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=CS1 Degrader C23H26N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-L6RH6W SCHEMBL31338399 3-[6-[[4-(2,3-dichlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=C(Cl)C(Cl)=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C25H23Cl2N3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-ILH1H2 SCHEMBL31338348 3-[6-[[4-(2,3-dichlorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C(Cl)C(Cl)=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H25Cl2N3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-3CH8Q6 SCHEMBL31337951 3-[6-[[4-(2,3-difluorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C(F)C(F)=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H25F2N3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-61J06P SCHEMBL31338048 3-[6-[[4-(2-chloro-3-fluorophenyl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C(Cl)C(F)=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H25ClFN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-YOPMZW SCHEMBL31338394 3-[6-[[4-(2-chloro-3-fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=C(Cl)C(F)=CC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C25H23ClFN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-6NNA5P SCHEMBL31338065 3-[6-[[4-(2,3-difluoropyridin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=C(F)C(F)=NC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H22F2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-E1I2EO SCHEMBL31338336 3-[6-[[4-(2,3-difluoropyridin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C(F)C(F)=NC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24F2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-1KDSDW SCHEMBL31337955 3-[6-[[4-(3-fluoro-4-iodopyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C(I)=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23FIN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-YJ0K0L SCHEMBL31338082 3-[6-[[4-(4,5-dichloropyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=C(Cl)C(Cl)=CN=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H22Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-BNSMZR SCHEMBL31338347 3-[6-[[4-(2,3-dichloropyridin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=C(Cl)C(Cl)=NC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H22Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-UM92S9 SCHEMBL31338034 3-[6-[[4-(2,3-dichloropyridin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C(Cl)C(Cl)=NC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-LE5ECE SCHEMBL31338223 3-[6-[[4-(3,4-dichloropyridin-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=C(Cl)C(Cl)=CC=N5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H22Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-E1IVF5 WO2025016359A1_04571 . O=C1C=CC(N2CC3=C(C=CC(CN4CCC(C5=CC=CS5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-G9LRXD SCHEMBL31338054 3-[6-[[4-(5-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC=C(C2=CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)S1 Degrader C24H25N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-PWUGYO SCHEMBL31338272 3-[6-[[4-(5-methylthiophen-2-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC=C(C2CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)S1 Degrader C24H27N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-WOIEBU SCHEMBL31338359 3-[6-[[4-(3-fluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-3030LX SCHEMBL31338112 3-[6-[[4-(3,4-difluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C(F)=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23F2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-P352KU SCHEMBL31338191 3-[6-[[4-(3-bromopyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC=C5Br)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24BrN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-IRV5XQ WO2025016359A1_04581 . O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC=C5F)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-6FNKEF SCHEMBL31338029 3-[3-oxo-6-[(4-thiophen-3-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=CSC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-PIP7CZ SCHEMBL31338286 3-[3-oxo-6-[(4-thiophen-3-ylpiperidin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCC(C5=CSC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H25N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-F2EBIC SCHEMBL31338387 3-[6-[[4-(5-methylthiophen-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC(C2=CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=CS1 Degrader C24H25N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-CK6NV7 SCHEMBL31337948 3-[6-[[4-(5-methylthiophen-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC(C2CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=CS1 Degrader C24H27N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-DC273Q SCHEMBL31338354 3-[6-[[4-(furan-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=COC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C23H23N3O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-92R0IE SCHEMBL31338317 3-[6-[[4-(furan-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=COC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H25N3O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-BO650H SCHEMBL31337941 3-[5-({[3,4'-bipiperidin]-1-yl}methyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione; EN300-43366542; 3-[5-({[3,4'-bipiperidin]-1-yl}methyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCCC(C5CCNCC5)C4)=C3)C2=O)C(=O)N1 Degrader C24H32N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-EGFOEN SCHEMBL31338108 3-[6-[[4-(3-bromo-5-chloropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Br)C=NC=C5Cl)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23BrClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-NOKBMZ SCHEMBL31338201 3-[3-oxo-6-[[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(/C5=C/NC6=C5C=CC=N6)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H26N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-QDPV3V SCHEMBL31338259 3-[3-oxo-6-[[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(/C5=C/NC6=C5C=CC=N6)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H25N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-5LQZUY SCHEMBL31338238 3-[3-oxo-6-[[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(/C5=C/NC6=C5C=CC=N6)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H27N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-S4RJSY SCHEMBL31338173 3-[6-[[4-(4-chloro-3-fluoropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C(Cl)=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23ClFN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-I9E4A3 SCHEMBL31338106 3-[6-[[4-(3-chloro-5-fluoropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(F)C=NC=C5Cl)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23ClFN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-X5X7BW SCHEMBL31338022 3-[6-[[4-(2-chloro-3-fluoropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC(Cl)=C5F)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23ClFN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-N9MA94 SCHEMBL31338120 3-[6-[[4-(2,6-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(C5=C(Cl)C=CC=C5Cl)CC4)=C3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-R8XHGY SCHEMBL31337958 3-[6-[[4-(3,5-dichlorophenyl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC(Cl)=CC(Cl)=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-NWYELV SCHEMBL31338152 3-[6-[[4-(3-bromo-4-chloropyridin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Br)C(Cl)=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23BrClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-4SJOZS SCHEMBL31338268 3-[6-[[4-(3-bromo-2-chloropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC(Cl)=C5Br)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23BrClN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-TDQ0VT SCHEMBL31338014 3-[6-[[4-(furan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(C5=CC=CO5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23N3O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-UT4LTP SCHEMBL31338214 3-[6-[[4-(furan-2-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=CC=CO5)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H25N3O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-Q7C68U SCHEMBL31338086 3-[6-[[4-(5-chloropyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC=C(C5=CC(Cl)=CN=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C24H23ClN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-FTG20N SCHEMBL31337956 3-[6-[[4-(7-fluoroquinolin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(/C5=C/C=N\C6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H27FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-1DSJ5I SCHEMBL31338217 3-[6-[[4-(7-fluoro-2,3-dihydrochromen-4-ylidene)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(=C5CCOC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H28FN3O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-3XYN9C SCHEMBL31338165 3-[6-[[4-(5-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(N5CCC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C27H29FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-6SVD4J SCHEMBL31338083 3-[6-[[3-(7-fluoroquinolin-4-yl)azetidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC(/C5=C/C=N\C6=C5C=CC(F)=C6)C4)=C/3)C2=O)C(=O)N1 Degrader C26H23FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-2N0Q4Q SCHEMBL31338353 3-[6-[[4-(5-fluoronaphthalen-1-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(/C5=C/C=C\C6=C5C=CC=C6F)CC4)=C/3)C2=O)C(=O)N1 Degrader C29H28FN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-4FUSBL SCHEMBL31338110 3-[6-[(4-isoquinolin-5-ylpiperidin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(/C5=C/C=C\C6=C5C=CN=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H28N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-2SFJRW SCHEMBL31337947 3-[6-[(4-isoquinolin-5-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(/C5=C/C=C\C6=C5C=CN=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H26N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-HGT46N SCHEMBL31338292 3-[6-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(/C5=N/OC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H24FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-W1AZGR SCHEMBL31338305 3-[6-[[3-(5-fluoro-2,3-dihydroindol-1-yl)azetidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC(N5CCC6=C5C=CC(F)=C6)C4)=C/3)C2=O)C(=O)N1 Degrader C25H25FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-2W6QNV SCHEMBL31338172 3-[3-oxo-6-[(4-thieno[2,3-d]pyrimidin-4-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6C=CSC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-X36I33 SCHEMBL31338351 3-[6-[[4-(5-methylthieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CSC2=NC=NC(N3CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)=C12 Degrader C25H26N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-MVAF4D SCHEMBL31338288 3-[6-[[4-(6-methylthieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC2=C(N3CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)N=CN=C2S1 Degrader C25H26N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-QYS57S SCHEMBL31338251 3-[3-oxo-6-[(4-thieno[3,2-d]pyrimidin-4-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6SC=CC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-NNWEWI SCHEMBL31338209 3-[6-[[4-(2-chlorothieno[3,2-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6SC=CC6=NC(Cl)=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H23ClN6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-THRKGK SCHEMBL31338008 3-[6-[[4-(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6SCCC6=NC(Cl)=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H25ClN6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-V13JB9 SCHEMBL31338356 3-[6-[[4-(3-fluoropyridin-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(C5=C(F)C=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H23FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-E19Y1C SCHEMBL31338176 3-[6-[[4-(3,4-dichloropyridin-2-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C(Cl)C(Cl)=CC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-ERAGRA SCHEMBL31338279 3-[6-[[4-(6-fluoro-3,4-dihydro-2H-quinolin-1-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(N5CCCC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H31FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-38DQMS SCHEMBL31338232 3-[3-oxo-6-[(4-thieno[2,3-d]pyrimidin-4-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(C5=C6C=CSC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H23N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-9LWFFN SCHEMBL31338318 3-[6-[[4-(2-methylthieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C=CSC2=N1 Degrader C25H26N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-CSO4NZ SCHEMBL31338107 3-[6-[[4-(4-morpholin-4-yl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(C5=N/C6=C(SCC6)/C(N6CCOCC6)=N\5)CC4)=C3)C2=O)C(=O)N1 Degrader C28H33N7O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-ABE39O SCHEMBL31338382 3-[3-oxo-6-[[4-(4-piperazin-1-ylthieno[3,2-d]pyrimidin-2-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(C5=N/C6=C(SC=C6)/C(N6CCNCC6)=N\5)CC4)=C3)C2=O)C(=O)N1 Degrader C28H32N8O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-S3VT3N SCHEMBL31338095 3-[6-[[3-(7-fluoro-3,4-dihydro-2H-chromen-4-yl)azetidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC(C5CCOC6=C5C=CC(F)=C6)C4)=C/3)C2=O)C(=O)N1 Degrader C26H26FN3O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-BVTURY WO2025016359A1_04701 . O=C1CCC(N2CC3=C(/C=C\C(CN4CC(=C5CCOC6=C5C=CC(F)=C6)C4)=C/3)C2=O)C(=O)N1 Degrader C26H24FN3O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-YFSNHR SCHEMBL31338372 3-[3-oxo-6-[(4-thieno[2,3-d]pyrimidin-4-ylpiperidin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C6C=CSC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-D4ZDLS SCHEMBL31337968 3-[6-[[4-(5-methylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CSC2=NC=NC(C3=CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)=C12 Degrader C26H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-ZN0AX6 SCHEMBL31338074 3-[6-[[4-(6-methylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC2=C(C3=CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)N=CN=C2S1 Degrader C26H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-AL4AMC SCHEMBL31338414 3-[3-oxo-6-[[4-(6-propan-2-ylthieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione CC(C)C1=CC2=C(N3CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)N=CN=C2S1 Degrader C27H30N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-GEFEND SCHEMBL31337944 3-[6-[[4-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(C)C2=C(N3CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)N=CN=C2S1 Degrader C26H28N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-7FO08H SCHEMBL31338503 3-[6-[[4-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-1,4-diazepan-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(C)C2=C(N3CCCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)N=CN=C2S1 Degrader C27H30N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-MFOOV9 SCHEMBL31338037 3-[3-oxo-6-[(4-thieno[2,3-d]pyrimidin-2-yl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(C5=NC=C6C=CSC6=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H23N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-9A2PEV SCHEMBL31338162 3-[3-oxo-6-[[4-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6C(C7=CC=CC=C7)=CSC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C30H28N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-Y9FN39 SCHEMBL31338025 3-[6-[[4-(2-morpholin-4-yl-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6SCCC6=NC(N6CCOCC6)=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H33N7O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-9XZON7 SCHEMBL31338080 3-[6-[[3-(2,3-dichlorophenyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4C5CC4CN(C4=C(Cl)C(Cl)=CC=C4)C5)=C3)C2=O)C(=O)N1 Degrader C25H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-1PDRJ3 SCHEMBL31338376 3-[6-[[4-(6-fluoro-1H-indol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(/C5=C/NC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C27H27FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-L8U16L SCHEMBL31338046 3-[6-[[4-(5-fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(N5C(=O)NC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H26FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-TUKOEF SCHEMBL31337966 3-[6-[[4-(1,2-oxazol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCC(C5=NOC=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C22H24N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-H7OH2V SCHEMBL31337976 3-[6-[[3-(5-fluorobenzimidazol-1-yl)azetidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC(N5/C=N\C6=C5C=CC(F)=C6)C4)=C/3)C2=O)C(=O)N1 Degrader C24H22FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-QVM4LZ SCHEMBL31338196 3-[6-[[4-(6-methylthieno[2,3-d]pyrimidin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC2=C(C3CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)N=CN=C2S1 Degrader C26H27N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-9B6DM4 SCHEMBL31338178 3-[6-[[4-(2-methylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(C2=CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C=CSC2=N1 Degrader C26H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-HGL10C SCHEMBL31338271 3-[3-oxo-6-[[4-(4-piperazin-1-yl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(C5=N/C6=C(SCC6)/C(N6CCNCC6)=N\5)CC4)=C3)C2=O)C(=O)N1 Degrader C28H34N8O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-30LQON SCHEMBL31338296 3-[6-[[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(/C5=C/NC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C27H25FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-HOXLFN SCHEMBL31338143 3-[6-[[4-(6-fluoro-1-methylindol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CN1/C=C(/C2=CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)C2=C1C=C(F)C=C2 Degrader C28H27FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-6M9SJA SCHEMBL31338380 3-[6-[[(1R,4R)-5-(2,3-dichlorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4C[C@H]5C[C@@H]4CN5C4=C(Cl)C(Cl)=CC=C4)=C3)C2=O)C(=O)N1 Degrader C25H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-N07Z2Z SCHEMBL31338265 3-[3-oxo-6-[(4-thieno[2,3-d]pyrimidin-2-ylpiperazin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=NC=C6C=CSC6=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-WD6P95 SCHEMBL31338250 3-[6-[[4-(2-methylthieno[2,3-d]pyrimidin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(C2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C=CSC2=N1 Degrader C26H27N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-KBMGZ0 SCHEMBL31337999 3-[6-[[4-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(C)C2=C(C3=CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)N=CN=C2S1 Degrader C27H27N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-8BOJOD SCHEMBL31338266 3-[7-[[4-(3-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(C2=CCN(CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)CC2)SC=C1 Degrader C24H25N3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-7GV0W6 SCHEMBL31338119 3-[7-fluoro-6-[[4-(3-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(C2=CCN(CC3=C(\F)C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)SC=C1 Degrader C24H24FN3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-YDT73C SCHEMBL31338051 3-[4-fluoro-6-[[4-(3-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(C2=CCN(CC3=C/C4=C(C(=O)N(C5CCC(=O)NC5=O)C4)/C(F)=C\3)CC2)SC=C1 Degrader C24H24FN3O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-SGW32V SCHEMBL31338333 2-(2,6-dioxopiperidin-3-yl)-4-[[4-(3-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione CC1=C(C2=CCN(CC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)SC=C1 Degrader C24H23N3O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-3538GF SCHEMBL31337972 2-(2,6-dioxopiperidin-3-yl)-5-[[4-(3-methylthiophen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]isoindole-1,3-dione CC1=C(C2=CCN(CC3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)SC=C1 Degrader C24H23N3O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-NQU7XD SCHEMBL31337996 3-[7-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC=C3CN3CCC(/C4=N/OC5=C4C=CC(F)=C5)CC3)C2=O)C(=O)N1 Degrader C26H25FN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-OFA19E SCHEMBL31338004 3-[7-fluoro-6-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(/C5=N/OC6=C5C=CC(F)=C6)CC4)=C/3F)C2=O)C(=O)N1 Degrader C26H24F2N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-4M0UHF SCHEMBL31338313 3-[5-fluoro-6-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C(F)\C(CN4CCC(/C5=N/OC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H24F2N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-BJHKN5 SCHEMBL31338157 3-[4-fluoro-6-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C2=O)/C(F)=C\C(CN2CCC(/C4=N/OC5=C4C=CC(F)=C5)CC2)=C/3)C(=O)N1 Degrader C26H24F2N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-TSITFX SCHEMBL31338345 3-[5-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C(CN4CCC(/C5=N/OC6=C5C=CC(F)=C6)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C26H25FN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-HJI0P4 SCHEMBL31338028 2-(2,6-Dioxopiperidin-3-yl)-4-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(C2=O)C(CN2CCC(/C4=N/OC5=C4C=CC(F)=C5)CC2)=CC=C3)C(=O)N1 Degrader C26H23FN4O5 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-3ZQRCB SCHEMBL31338239 2-(2,6-Dioxopiperidin-3-yl)-5-[[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(CN4CCC(/C5=N/OC6=C5C=CC(F)=C6)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C26H23FN4O5 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-S7LY81 SCHEMBL31338150 3-[6-[[3-(2,3-dichlorophenyl)-3,8-diazabicyclo[3.2.1]octan-8-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4C5CCC4CN(C4=C(Cl)C(Cl)=CC=C4)C5)=C3)C2=O)C(=O)N1 Degrader C26H26Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-EP0AF4 SCHEMBL31337988 3-[6-[[4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCCN(C5=C(Cl)C(Cl)=CC=C5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H26Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-3FY2BE SCHEMBL31338132 3-[6-[[4-(6-fluoro-1-methylindol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CN1/C=C(/C2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)C2=C1C=C(F)C=C2 Degrader C28H29FN4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-LWMNJB SCHEMBL31338280 3-[6-[[4-(7-fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(N5CCOC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C27H29FN4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-FX3N49 SCHEMBL31337975 3-[6-[[4-(7-fluoro-3-oxo-1,4-benzoxazin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(N5C(=O)COC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C27H27FN4O5 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-UM55QS SCHEMBL31337935 3-[6-[[4-(6-bromothieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6C=C(Br)SC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H23BrN6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-8T07DE SCHEMBL31338285 3-[3-oxo-6-[[4-(6-phenylthieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6C=C(C7=CC=CC=C7)SC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C30H28N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-JSSCIS SCHEMBL31337942 3-[6-[[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(C2=CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C(=N1)SC1=C2CCCC1 Degrader C30H31N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-HKS1EW SCHEMBL31337950 3-[6-[[4-(2,4-dichloropyridin-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C(Cl)C=CN=C5Cl)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23Cl2N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-UZ9OUU SCHEMBL31338069 3-[6-[[6-(2,3-dichlorophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC5CC(C4)N5C4=C(Cl)C(Cl)=CC=C4)=C3)C2=O)C(=O)N1 Degrader C25H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-VAI5F5 SCHEMBL31338379 3-[6-[[(1S,4S)-5-(2,3-dichlorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4C[C@@H]5C[C@H]4CN5C4=C(Cl)C(Cl)=CC=C4)=C3)C2=O)C(=O)N1 Degrader C25H24Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-K678IX SCHEMBL31337974 3-[6-[[8-(2,3-dichlorophenyl)-3,8-diazabicyclo[3.2.1]octan-3-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC5CCC(C4)N5C4=C(Cl)C(Cl)=CC=C4)=C3)C2=O)C(=O)N1 Degrader C26H26Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-A6IDLN WO2025016359A1_04900 . CC1=NC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C(=N1)SC1=C2CCCCC1 Degrader C30H34N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-92KFFB SCHEMBL31337998 3-[6-[[4-(7-fluoro-3,4-dihydro-2H-chromen-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5CCOC6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H30FN3O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-25EUOR SCHEMBL31337991 3-[6-[[4-(5-fluoronaphthalen-1-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(/C5=C/C=C\C6=C5C=CC=C6F)CC4)=C/3)C2=O)C(=O)N1 Degrader C29H26FN3O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-DF6JT3 SCHEMBL31338151 3-[6-[[4-(2-morpholin-4-ylthieno[3,2-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6SC=CC6=NC(N6CCOCC6)=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H31N7O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-47W6XW SCHEMBL31337954 3-[6-[[4-([1,2]oxazolo[4,5-c]pyridin-3-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(/C5=N/OC6=C5C=NC=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C24H24N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-23MVEW SCHEMBL31338208 3-[6-[[4-(5-fluorobenzimidazol-1-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(N5/C=N\C6=C5C=CC(F)=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H26FN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-3L7O6S SCHEMBL31338304 3-[6-[[4-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CCN(C5=N/C6=C(SC=C6)/C(N6CCOCC6)=N\5)CC4)=C3)C2=O)C(=O)N1 Degrader C28H31N7O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-2UIEQ6 SCHEMBL31338130 3-[6-[[4-(1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(/C5=N/OC6=C5C=CC=C6)CC4)=C/3)C2=O)C(=O)N1 Degrader C26H26N4O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-BUD538 SCHEMBL31338373 3-[3-oxo-6-[[4-(5-phenylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(C5=C6C(C7=CC=CC=C7)=CSC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C31H27N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-70X5J8 SCHEMBL31338303 3-[7-[[4-(1-benzothiophen-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC=C3CN3CCN(C4=C5C=CSC5=CC=C4)CC3)C2=O)C(=O)N1 Degrader C26H26N4O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-HOOSCB SCHEMBL31338047 5-[[4-(1-Benzothiophen-4-yl)piperazin-1-yl]methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(C=C(CN4CCN(C5=C6C=CSC6=CC=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C26H24N4O4S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-LKXN55 SCHEMBL31338276 3-[3-oxo-7-[[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC=C3CN3CCN4C(=NN=C4C(F)(F)F)C3)C2=O)C(=O)N1 Degrader C20H19F3N6O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-FWWP01 SCHEMBL31338002 2-(2,6-dioxopiperidin-3-yl)-5-[[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methyl]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(C=C(CN4CCN5C(=NN=C5C(F)(F)F)C4)C=C3)C2=O)C(=O)N1 Degrader C20H17F3N6O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-OMEM41 SCHEMBL31338343 3-[6-[[4-(2-bromo-3-fluoropyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC(Br)=C5F)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H23BrFN5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-WIV2UO SCHEMBL31338128 3-[6-[[4-(3-fluoro-2-oxo-1H-pyridin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=CC=NC(O)=C5F)CC4)=C/3)C2=O)C(=O)N1 Degrader C23H24FN5O4 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-BHZ2L5 SCHEMBL31337995 3-[6-[[5-(2,3-dichlorophenyl)-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(C=CC(CN4CC5CCC4CN5C4=C(Cl)C(Cl)=CC=C4)=C3)C2=O)C(=O)N1 Degrader C26H26Cl2N4O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-QCH1IO SCHEMBL31338156 3-[3-oxo-6-[(4-thieno[2,3-d]pyrimidin-2-ylpiperidin-1-yl)methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=NC=C6C=CSC6=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C25H25N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-R94K21 SCHEMBL31338099 3-[3-oxo-6-[[4-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(C5=C6C(=NC=N5)SC5=C6CCC5)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H27N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-H6JO63 SCHEMBL31338293 3-[3-oxo-6-[[4-(6-propan-2-ylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione CC(C)C1=CC2=C(C3=CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)N=CN=C2S1 Degrader C28H29N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-AWAH0J SCHEMBL31337971 3-[6-[[4-(5-ethylpyrimidin-2-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CCC1=CN=C(C2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)N=C1 Degrader C25H29N5O3 WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-PJ2X5W SCHEMBL31338103 3-[6-[[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(C2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C(=N1)SC1=C2CCCC1 Degrader C30H33N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-4SAH8S SCHEMBL31338155 3-[3-oxo-6-[[4-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-yl)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C6C(=NC=N5)SC5=C6CCC5)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H29N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-N79TB9 SCHEMBL31338042 3-[3-oxo-6-[[4-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C6C(C7=CC=CC=C7)=CSC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C31H29N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-UZA0Z3 SCHEMBL31338121 3-[3-oxo-6-[[4-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6C(=NC=N5)SC5=C6CCC5)CC4)=C/3)C2=O)C(=O)N1 Degrader C27H28N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-G33MFD SCHEMBL31338392 3-[6-[[4-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=C(C)C2=C(C3CCN(CC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5)CC3)N=CN=C2S1 Degrader C27H29N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-L92E1V SCHEMBL31338193 3-[6-[[4-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C(C3=CC=CC=C3)=CSC2=N1 Degrader C31H30N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-CAE44E SCHEMBL31338218 3-[3-oxo-6-[[4-(6-phenylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CC=C(C5=C6C=C(C7=CC=CC=C7)SC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C31H27N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-WS28R0 SCHEMBL31338114 3-[6-[[4-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(C2=CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C(C3=CC=CC=C3)=CSC2=N1 Degrader C32H29N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-CTL3NJ SCHEMBL31338229 3-[6-[[4-(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-yl)piperazin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(N2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C(=N1)SC1=C2CCC1 Degrader C28H30N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-KP2CEK SCHEMBL31338118 3-[6-[[4-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC(C2CCN(CC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C2C(C3=CC=CC=C3)=CSC2=N1 Degrader C32H31N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-09M5LZ SCHEMBL31338023 3-[3-oxo-6-[[4-(6-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCC(C5=C6C=C(C7=CC=CC=C7)SC6=NC=N5)CC4)=C/3)C2=O)C(=O)N1 Degrader C31H29N5O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-YF3SSQ SCHEMBL31338184 3-[3-oxo-6-[[4-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methyl]-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=C(/C=C\C(CN4CCN(C5=C6C(=NC=N5)SC5=C6CCCC5)CC4)=C/3)C2=O)C(=O)N1 Degrader C28H30N6O3S WEE1;IKZF1;IKZF2;IKZF3;GSPT1;CK1α P30291/Q13422/Q9UKS7/Q9UKT9/P15170/P48729 CRBN WO-2025016359-A1 TPD-F7YOZD WO2025024030A2_JWJ-01-200 . CCC(C)(NCCC1=CC(Cl)=C(C(F)(F)F)C=C1)C1=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1 Degrader C28H28ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-TZGO96 SCHEMBL24046521 3-[3-[3-[2-[2-[3-Chloro-4-(trifluoromethyl)phenyl]ethylamino]propan-2-yl]anilino]-2,5-dioxopyrrol-1-yl]piperidine-2,6-dione; SCHEMBL30219744 CC(C)(NCCC1=CC(Cl)=C(C(F)(F)F)C=C1)C1=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1 Degrader C27H26ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-PSB21Z SCHEMBL31292844 3-[3-[3-[3-[2-[3-Chloro-4-(trifluoromethyl)phenyl]ethylamino]pentan-3-yl]anilino]-2,5-dioxopyrrol-1-yl]piperidine-2,6-dione CCC(CC)(NCCC1=CC(Cl)=C(C(F)(F)F)C=C1)C1=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1 Degrader C29H30ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-H1UZ0K SCHEMBL31292824 3-[3-[3-[[2-[3-Chloro-4-(trifluoromethyl)phenyl]ethylamino]-phenylmethyl]anilino]-2,5-dioxopyrrol-1-yl]piperidine-2,6-dione O=C1CCC(N2C(=O)C=C(NC3=CC(C(NCCC4=CC(Cl)=C(C(F)(F)F)C=C4)C4=CC=CC=C4)=CC=C3)C2=O)C(=O)N1 Degrader C31H26ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-E2WNCO WO2025024030A2_JWJ-01-216 . CC(C)(NCCCC1=CC(Cl)=C(C(F)(F)F)C=C1)C1=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1 Degrader C28H28ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-XMPXCH SCHEMBL31292894 N-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]benzenesulfonamide O=C1CCC(N2C(=O)C=C(NC3=CC=CC(S(=O)(=O)NCCC4=CC(Cl)=C(C(F)(F)F)C=C4)=C3)C2=O)C(=O)N1 Degrader C24H20ClF3N4O6S ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-0FRAJK SCHEMBL31292641 3-[3-[3-[2-[2-[3-Chloro-4-(trifluoromethyl)phenyl]ethylamino]propan-2-yl]-4-methylanilino]-2,5-dioxopyrrol-1-yl]piperidine-2,6-dione CC1=C(C(C)(C)NCCC2=CC(Cl)=C(C(F)(F)F)C=C2)C=C(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)C=C1 Degrader C28H28ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-DXCNFP WO2025024030A2_JWJ-01-227 . CC1=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=CC(C(C)(C)NCCC2=CC(Cl)=C(C(F)(F)F)C=C2)=C1 Degrader C28H28ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-K66LC1 WO2025024030A2_JWJ-01-231 . O=C1CCC(N2C(=O)C=C(NC3=CC=C(C4CCN(CC5=CC(Cl)=C(C(F)(F)F)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C28H26ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-5RMF41 WO2025024030A2_JWJ-01-235 . O=C1CCC(N2C(=O)C=C(NC3=CC=CC(C4CCN(CC5=CC(Cl)=C(C(F)(F)F)C=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C28H26ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-1GD16I WO2025024030A2_JWJ-01-237 . O=C1CCC(N2C(=O)C=C(NC3=CC=CC(C4CCN(CCC5=CC(Cl)=C(C(F)(F)F)C=C5)CC4)=C3)C2=O)C(=O)N1 Degrader C29H28ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-MH2YSG WO2025024030A2_JWJ-01-238 . O=C1CCC(N2C(=O)C=C(NC3=CC=C(C4CCN(CCC5=CC(Cl)=C(C(F)(F)F)C=C5)CC4)C=C3)C2=O)C(=O)N1 Degrader C29H28ClF3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-B0ITK8 SCHEMBL31292564 3-[3-[4-[1-[[3-Chloro-4-(trifluoromethyl)phenyl]methyl]triazol-4-yl]anilino]-2,5-dioxopyrrol-1-yl]piperidine-2,6-dione O=C1CCC(N2C(=O)C=C(NC3=CC=C(C4=CN(CC5=CC(Cl)=C(C(F)(F)F)C=C5)N=N4)C=C3)C2=O)C(=O)N1 Degrader C25H18ClF3N6O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-CV5UX6 SCHEMBL31292811 3-[3-[4-[1-[2-[3-Chloro-4-(trifluoromethyl)phenyl]ethyl]triazol-4-yl]anilino]-2,5-dioxopyrrol-1-yl]piperidine-2,6-dione O=C1CCC(N2C(=O)C=C(NC3=CC=C(C4=CN(CCC5=CC=C(C(F)(F)F)C(Cl)=C5)N=N4)C=C3)C2=O)C(=O)N1 Degrader C26H20ClF3N6O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-PVYTA8 WO2025024030A2_JWJ-01-251 . O=C1CCC(N2C(=O)C=C(NC3=CC=CC(C4=CN(CC5=CC=C(C(F)(F)F)C(Cl)=C5)N=N4)=C3)C2=O)C(=O)N1 Degrader C25H18ClF3N6O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-QIZI51 SCHEMBL31292731 3-[2,5-Dioxo-3-[3-[2-(2-phenylethylamino)butan-2-yl]anilino]pyrrol-1-yl]piperidine-2,6-dione CCC(C)(NCCC1=CC=CC=C1)C1=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1 Degrader C27H30N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-3RWPJA SCHEMBL31292760 3-[3-[3-[1-[2-[3-Chloro-4-(trifluoromethyl)phenyl]ethyl]triazol-4-yl]anilino]-2,5-dioxopyrrol-1-yl]piperidine-2,6-dione O=C1CCC(N2C(=O)C=C(NC3=CC=CC(C4=CN(CCC5=CC=C(C(F)(F)F)C(Cl)=C5)N=N4)=C3)C2=O)C(=O)N1 Degrader C26H20ClF3N6O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-S52KCS SCHEMBL31292743 3-[2,5-Dioxo-3-[3-[2-[2-[4-(trifluoromethyl)phenyl]ethylamino]butan-2-yl]anilino]pyrrol-1-yl]piperidine-2,6-dione CCC(C)(NCCC1=CC=C(C(F)(F)F)C=C1)C1=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1 Degrader C28H29F3N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-8XS2RX WO2025024030A2_JWJ-01-260 . CCC(C)(NCCC1=CC=C(OC)C=C1)C1=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1 Degrader C28H32N4O5 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-2Y99WV WO2025024030A2_JWJ-01-261 . CCC(C)(NCCC1=CC=C(C)C=C1)C1=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1 Degrader C28H32N4O4 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-TULTDP WO2025024030A2_JWJ-01-265 . CCC(C)(NCCC1=CC=C(OC)C(Cl)=C1)C1=CC=CC(NC2=CC(=O)N(C3CCC(=O)NC3=O)C2=O)=C1 Degrader C28H31ClN4O5 ZBTB11 O95625 CRBN WO-2025024030-A2 TPD-TLKZED WO2025026218A1_C001 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NCC(F)(F)F)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C23H20F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-WZ8HXE WO2025026218A1_C002 . CN(CC(F)(F)F)C1=CC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1 Degrader C24H22F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-UQ5HXT WO2025026218A1_C003 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5=C(F)C=CC=C5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C27H22F2N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-7SSVXQ WO2025026218A1_C004 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5=C(C(F)(F)F)C=CC=C5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C28H22F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-MWJ89F WO2025026218A1_C005 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5=C(F)C=CC=C5F)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C27H21F3N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-NBV1AH WO2025026218A1_C006 . O=C1CCC(N2CC3=C(C=C(COC(=O)NC4=CC(NC5=CC=CC(F)=C5F)=CC=C4F)C=C3)C2=O)C(=O)N1 Degrader C27H21F3N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-PX6GTA WO2025026218A1_C007 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5=C(F)C=NC=C5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C26H21F2N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-9UTCFH WO2025026218A1_C008 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5=C(F)C=CC=N5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C26H21F2N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-9VJSCT WO2025026218A1_C009 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5=C(Cl)C=CC=C5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C27H22ClFN4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-LFVMSD WO2025026218A1_C010 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NCC5=C(F)C=CC=C5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C28H24F2N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-OR4VX0 WO2025026218A1_C011 . CN(C1=CC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1)C1C=CC=CC1F Degrader C28H26F2N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-DGXPU1 WO2025026218A1_C012 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=CC(NC5=C(C(F)(F)F)C=CC=C5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C29H24F4N4O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-GC7J1D WO2025026218A1_C013 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=CC(NCC5=C(F)C=CC=C5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C29H26F2N4O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-P3A2NH WO2025026218A1_C017 . COCC(F)(F)CNC1=CC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1 Degrader C25H25F3N4O6 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-VLLJBK WO2025026218A1_C018 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=NC(NC5CCC(F)(F)CC5)=NC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C25H25F3N6O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-3AB9X7 WO2025026218A1_C019 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5CCC(F)(F)CC5)=CC=C4F)\C=C/3F)C2=O)C(=O)N1 Degrader C27H26F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-U2S21F WO2025026218A1_C020 . CO/C1=C/C(COC(=O)NC2=CC(NC3CCC(F)(F)CC3)=CC=C2F)=C\C2=C1CN(C1CCC(=O)NC1=O)C2=O Degrader C28H29F3N4O6 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-HCDI5W WO2025026218A1_C021 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NCC5=C(F)C=CC=C5)=CC=C4F)\C=C/3F)C2=O)C(=O)N1 Degrader C28H23F3N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-JKMBGW WO2025026218A1_C022 . O=C1CCC(N2CC3=C(C2=O)/C(F)=C(COC(=O)NC2=CC(NC4CCC(F)(F)CC4)=CC=C2F)\C=C/3)C(=O)N1 Degrader C27H26F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-6TT4UZ WO2025026218A1_C023 . O=C1CCC(N2CC3=C(C=C(CNC(=O)C4=CC(NC5CCC(F)(F)CC5)=CC=C4F)C=C3F)C2=O)C(=O)N1 Degrader C27H26F4N4O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-N0FTGH WO2025026218A1_C024 . CCN(CC(F)(F)F)C1=CC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1 Degrader C25H24F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-XD9BGO WO2025026218A1_C025 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(N(CC(F)(F)F)C5CC5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C26H24F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-IX38DI WO2025026218A1_C026 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=CC(CN5CCC(F)(F)CC5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C28H29F3N4O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-T9CK08 WO2025026218A1_C027 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NCC(F)(F)F)=NC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C22H19F4N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-GCRV9T WO2025026218A1_C028 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5CCC(F)(F)CC5)=NC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C26H26F3N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-UQTZ18 WO2025026218A1_C029 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NCC5=C(F)C=CC=C5)=NC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C27H23F2N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-8OP4Z2 WO2025026218A1_C030 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=NC(NCC5=C(F)C=CC=C5)=NC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C26H22F2N6O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-B36S1B WO2025026218A1_C031 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=NC(NCC(F)(F)F)=NC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C21H18F4N6O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-7N3SD5 WO2025026218A1_C032 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=CC(NCC(F)(F)F)=NC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C23H22F3N5O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-ZGV6V7 WO2025026218A1_C033 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=CC(NC5CCC(F)(F)CC5)=NC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C27H29F2N5O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-CHXEIS WO2025026218A1_C034 . N#CC1=C(NCC(F)(F)F)C=C(NC(=O)CCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)C(F)=C1 Degrader C25H21F4N5O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-HYCB0R WO2025026218A1_C035 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=CC(NCC(F)(F)F)=C(Cl)C=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C24H21ClF4N4O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-Q9413J WO2025026218A1_C036 . N#CC1=C(NCC(F)(F)F)C=C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C24H20F3N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-MVEJ3E WO2025026218A1_C037 . N#CC1=C(NCC(F)(F)F)C=C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)C(F)=C1 Degrader C24H19F4N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-Z96QD2 WO2025026218A1_C039 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=C/C5=C(C=CN5)/C=C\4F)\C=C/3)C2=O)C(=O)N1 Degrader C23H19FN4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-YVDHAW WO2025026218A1_C040 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=C/C5=C(C=NN5)/C=C\4F)\C=C/3)C2=O)C(=O)N1 Degrader C22H18FN5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-G9QPJP WO2025026218A1_C041 . CP(C)(=O)C1=CC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1 Degrader C23H23FN3O6P GSPT1 P15170 CRBN WO-2025026218-A1 TPD-QA5BQZ WO2025026218A1_C042 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(S(F)(F)(F)(F)F)=CC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C21H18F5N3O5S GSPT1 P15170 CRBN WO-2025026218-A1 TPD-Y8Y8HX WO2025026218A1_C043 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=C/C5=C(\C=C/4F)CCC5NCC(F)(F)F)\C=C/3)C2=O)C(=O)N1 Degrader C26H24F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-EDQT17 WO2025026218A1_C044 . CC(NC1=CC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1)C(F)(F)F Degrader C24H22F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-LB871B WO2025026218A1_C045 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5=C(C(F)(F)F)C=CC=C5)=NC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C27H21F4N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-7AMAUX WO2025026218A1_C046 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=NC(NC5=C(C(F)(F)F)C=CC=C5)=NC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C26H20F4N6O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-QPCGK3 WO2025026218A1_C047 . O=C1CCC(N2CC3=C(C=C(CCC(=O)NC4=CC(NC5=C(C(F)(F)F)C=CC=C5)=NC=C4F)C=C3)C2=O)C(=O)N1 Degrader C28H23F4N5O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-NSMYRP WO2025026218A1_C048 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=NC(NC5=C(C(F)(F)F)C=CC=C5)=NC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C27H22F4N6O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-2DXJ09 WO2025026218A1_C049 . CO/C1=C/C(CCC(=O)NC2=CC(NC3CCC(F)(F)CC3)=CC=C2F)=C\C2=C1CN(C1CCC(=O)NC1=O)C2=O Degrader C29H31F3N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-RLPEW5 WO2025026218A1_C050 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=CC(NC5CCC(F)(F)CC5)=CC=C4F)\C=C/3F)C2=O)C(=O)N1 Degrader C28H28F4N4O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-JFVBR1 WO2025045761A1_2384 . N[C@H]1CC[C@H](NC2=N/C3=C(Br)C=NN3/C(NCC3=CC=C(C4=NC=CC=C4)C=C3)=N\2)CC1 Degrader C23H25BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-86YMG4 WO2025045761A1_2388 . BrC1=C2/N=C(NC3CCNCC3)\N=C(\NCC3=CC=C(C4=NC=CC=C4)C=C3)N2N=C1 Degrader C22H23BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-R9KGKL WO2025045761A1_2538 . O[C@H]1CN[C@H](CNC2/N=C(/NCC3=CC=C(C4=NC=CC=C4)C=C3)N3N=CC(Br)=C3N2)C1 Degrader C22H25BrN8O CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-U99ZS4 WO2025045761A1_2559 . NC1CCN(C2=N/C3=C(Br)C=NN3/C(NCC3=CC=C(C4=NC=CC=C4)C=C3)=N\2)CC1 Degrader C22H23BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-94F521 WO2025045761A1_2560 . NCC1CCN(C2=N/C3=C(Br)C=NN3/C(NCC3=CC=C(C4=NC=CC=C4)C=C3)=N\2)CC1 Degrader C23H25BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-DM1J6Z WO2025045761A1_2568 . N[C@H]1CC[C@@H](NC2=NC3=C(Br)C=NN3C(NCC3=CC=C(C4=NC=CC=C4)C=C3)=N2)CC1 Degrader C23H25BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-OXXT4X WO2025045761A1_2569 . BrC1=C2/N=C(NCC3CCNCC3)\N=C(\NCC3=CC=C(C4=NC=CC=C4)C=C3)N2N=C1 Degrader C23H25BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-Y2VINU WO2025045761A1_2571 . BrC1=C2/N=C(NC[C@@H]3CCCN3)\N=C(\NCC3=CC=C(C4=NC=CC=C4)C=C3)N2N=C1 Degrader C22H23BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-BO8A2K WO2025045761A1_2584 . NC1=CC=C(NC2=NC3=C(Br)C=NN3C(NCC3=CC=C(C4=NC=CC=C4)C=C3)=N2)C=C1 Degrader C23H19BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-1A34AB WO2025045761A1_2585 . NCCCCNC1=N/C2=C(Br)C=NN2/C(NCC2=CC=C(C3=NC=CC=C3)C=C2)=N\1 Degrader C21H23BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-92W2F5 WO2025045761A1_2586 . CNCCNC1=NC2=C(Br)C=NN2C(NCC2=CC=C(C3=NC=CC=C3)C=C2)=N1 Degrader C20H21BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-W1W9EO WO2025045761A1_2590 . N[C@H]1CC[C@H](NC2=N/C3=C(I)C=NN3/C(NCC3=CC=C(C4=NC=CC=C4)C=C3)=N\2)CC1 Degrader C23H25IN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-LDHDQJ WO2025045761A1_2600 . CN(CCN)C1=NC2=C(Br)C=NN2C(NCC2=CC=C(C3=NC=CC=C3)C=C2)=N1 Degrader C20H21BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-Z1AMWK WO2025045761A1_2601 . BrC1=C2/N=C(N3CCNCC3)\N=C(\NCC3=CC=C(C4=NC=CC=C4)C=C3)N2N=C1 Degrader C21H21BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-3EIU43 WO2025045761A1_2605 . CNCCN(C)C1=N/C2=C(Br)C=NN2/C(NCC2=CC=C(C3=NC=CC=C3)C=C2)=N\1 Degrader C21H23BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-5LBL8T WO2025045761A1_2606 . BrC1=C2/N=C(NC3CCCNC3)\N=C(\NCC3=CC=C(C4=NC=CC=C4)C=C3)N2N=C1 Degrader C22H23BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-HEEEOA WO2025051180A1_1 . CC1=C(Cl)C=C(NC(=O)OCC2=C/C3=C4C(=CC=C3)N(C3CCC(=O)NC3=O)C(=O)\C4=C\2)C=C1 Degrader C25H20ClN3O5 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-FHVM3R WO2025051180A1_10 . O=C1CCC(N2C(=O)/C3=C/C(COC(=O)NC4=CC=C(Cl)C(OC(F)F)=C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C25H18ClF2N3O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-EK6TC6 WO2025051180A1_11 . O=C1CCC(N2C(=O)/C3=C/C(COC(=O)NC4=CC(Cl)=CC(OC(F)F)=C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C25H18ClF2N3O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-PKV84E WO2025051180A1_12 . O=C1CCC(N2C(=O)/C3=C/C(COC(=O)NC4=CC=C(OC(F)(F)F)C=C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C25H18F3N3O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-YGB3A0 WO2025051180A1_13 . CC(C)(C)C1=C(Cl)C=C(NC(=O)OCC2=C/C3=C4C(=CC=C3)N(C3CCC(=O)NC3=O)C(=O)\C4=C\2)C=C1 Degrader C28H26ClN3O5 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-SVICVQ WO2025051180A1_14 . O=C1CCC(N2C(=O)/C3=C/C(COC(=O)NC4=C(F)C=CC(OC(F)F)=C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C25H18F3N3O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-0NRB7B WO2025051180A1_15 . CC1CN(CC2=CC(NC(=O)OCC3=C/C4=C5C(=CC=C4)N(C4CCC(=O)NC4=O)C(=O)\C5=C\3)=CC(OC(F)(F)F)=C2F)CC(C)O1 Degrader C32H30F4N4O7 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-ZF8IQ0 WO2025051180A1_16 . O=C1CCC(N2C(=O)/C3=C/C(COC(=O)NC4=CC(OC(F)(F)F)=C(F)C(CN5CCOCC5)=C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C30H26F4N4O7 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-HZQFFV WO2025051180A1_17 . O=C1CCC(C2=C(F)C=C(N3CC(NC(=O)NC4=CC(S(F)(F)(F)(F)F)=CC=C4)C3)C=C2F)C(=O)N1 Degrader C21H19F7N4O3S GSPT1 P15170 CRBN WO-2025051180-A1 TPD-C2UVH1 WO2025051180A1_18 . O=C1CCC(C2=COC3=CC(CNC(=O)NC4=CC=C(S(F)(F)(F)(F)F)C=C4)=CC=C32)C(=O)N1 Degrader C21H18F5N3O4S GSPT1 P15170 CRBN WO-2025051180-A1 TPD-HMYNZI WO2025051180A1_19 . O=C1CCC(C2=C(F)C=C(N3CC(OC(=O)NC4=CC(S(F)(F)(F)(F)F)=CC=C4)C3)N=C2)C(=O)N1 Degrader C20H18F6N4O4S GSPT1 P15170 CRBN WO-2025051180-A1 TPD-WVX5WR WO2025051180A1_2 . O=C1CCC(N2C(=O)C3=CC(COC(=O)NC4=CC=C(F)C(OC(F)(F)F)=C4)=CC4=C3C2=CC=C4)C(=O)N1 Degrader C25H17F4N3O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-L1GSTZ WO2025051180A1_20 . O=C1CCC(N2C(=O)/C3=C/C(N4CC(OC(=O)NC5=CC(OC(F)(F)F)=CC(Cl)=C5)C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C27H20ClF3N4O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-EMCWWT WO2025051180A1_21 . O=C1CCC(N2C(=O)/C3=C/C(N4CC(OC(=O)NC5=CC(OC(F)(F)F)=C(F)C=C5)C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C27H20F4N4O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-QAIFIB WO2025051180A1_22 . O=C1CCC(N2C(=O)/C3=C/C(N4CC(OC(=O)NC5=CC(OC(F)(F)F)=CC=C5F)C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C27H20F4N4O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-5JSF0J WO2025051180A1_23 . O=C1CCC(N2C(=O)/C3=C/C(N4CC(OC(=O)NC5=CC(OC(F)F)=CC(Cl)=C5)C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C27H21ClF2N4O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-FRMO0D WO2025051180A1_24 . O=C1CCC(N2C(=O)/C3=C/C(N4CC(OC(=O)NC5=CC(OC(F)(F)F)=C(C6=CC=CC=C6)C=C5)C4)=C\C4=C3C2=CC=C4)C(=O)N1 Degrader C33H25F3N4O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-5XIHDU WO2025051180A1_25 . O=C1CCC(N2C(=O)C3=CC(N4CC(OC(=O)NC5=CC=CC(OC(F)(F)F)=C5)C4)=CC4=C3/C2=C\C=C/4)C(=O)N1 Degrader C27H21F3N4O6 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-DMSNZH WO2025051180A1_26 . CNCCOCCC1=C(OC(F)F)C=C(NC(=O)OCC2=C/C3=C4C(=CC=C3)N(C3CCC(=O)NC3=O)C(=O)\C4=C\2)C=C1 Degrader C30H30F2N4O7 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-Y5CNU1 WO2025051180A1_27 . O=C1CCC(C2=C(F)C=C(N3CC(OC(=O)NC4=CC(S(F)(F)(F)(F)F)=CC=C4)C3)C=C2F)C(=O)N1 Degrader C21H18F7N3O4S GSPT1 P15170 CRBN WO-2025051180-A1 TPD-EY1VJN WO2025051180A1_28 . CN1CCN(C(=O)C2=CC(NC(=O)OCC3=C/C4=C5C(=CC=C4)N(C4CCC(=O)NC4=O)C(=O)\C5=C\3)=CC(OC(F)(F)F)=C2)CC1 Degrader C31H28F3N5O7 GSPT1 P15170 CRBN WO-2025051180-A1 TPD-IN25OQ WO2025051180A1_29 . O=C1CCC(C2=C(F)C=C(N3CC(NC(=O)NC4=CC=C(S(F)(F)(F)(F)F)C=C4)C3)C=C2F)C(=O)N1 Degrader C21H19F7N4O3S GSPT1 P15170 CRBN WO-2025051180-A1 TPD-Y1VB3N SCHEMBL31583009 4-[1-[(3-Fluorophenyl)methyl]triazol-4-yl]-1-[2-(3-methoxyphenyl)ethyl]piperidine COC1=CC(CCN2CCC(C3=CN(CC4=CC=CC(F)=C4)N=N3)CC2)=CC=C1 Stabilizer C23H27FN4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-8K2EN2 SCHEMBL31582821 4-[1-[(4-Fluorophenyl)methyl]triazol-4-yl]-1-[2-(4-methoxyphenyl)ethyl]piperidine COC1=CC=C(CCN2CCC(C3=CN(CC4=CC=C(F)C=C4)N=N3)CC2)C=C1 Stabilizer C23H27FN4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-OZTKVD WO2025104092A1_100 . CN1C=C(Cl)C(CN2CCC(C3=CN(C4=CC(C(F)(F)F)=CC=C4)N=N3)CC2)=N1 Stabilizer C19H20ClF3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-S4S476 WO2025104092A1_101 . CC1=CC=C(CN2CCC(C3=CN(C4=CC=CC(C(F)(F)F)=C4)N=N3)CC2)O1 Stabilizer C20H21F3N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-KF65VD WO2025104092A1_102 . CC1=CN=C(CN2CCC(C3=CN(C4=CC=CC(C(F)(F)F)=C4)N=N3)CC2)S1 Stabilizer C19H20F3N5S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-IDYU38 WO2025104092A1_103 . CC1=NC(CN2CCC(C3=CN(C4=CC(C(F)(F)F)=CC=C4)N=N3)CC2)=CS1 Stabilizer C19H20F3N5S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-Q4P84H WO2025104092A1_104 . CC1=C(C)SC(CN2CCC(C3=CN(C4=CC(C(F)(F)F)=CC=C4)N=N3)CC2)=N1 Stabilizer C20H22F3N5S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-4SKXRP WO2025104092A1_105 . COC1=CC=CC(OC)=C1CN1CCC(C2=CN(C3=CC=C(C(F)(F)F)C=C3)N=N2)CC1 Stabilizer C23H25F3N4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-D5GWLD WO2025104092A1_106 . CC1=CC=CC=C1CN1CCC(C2=CN(C3=CC=C(C(F)(F)F)C=C3)N=N2)CC1 Stabilizer C22H23F3N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-7CU2TR WO2025104092A1_107 . OC1=C(CN2CCC(C3=CN(C4=CC=C(C(F)(F)F)C=C4)N=N3)CC2)C=CC=C1 Stabilizer C21H21F3N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-258G99 WO2025104092A1_108 . FC(F)OC1=CC=C(CN2CCC(C3=CN(C4=CC=C(C(F)(F)F)C=C4)N=N3)CC2)C=C1 Stabilizer C22H21F5N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-OKEZCP WO2025104092A1_109 . CC1=C(F)C=CC(CN2CCC(C3=CN(C4=CC=C(C(F)(F)F)C=C4)N=N3)CC2)=C1 Stabilizer C22H22F4N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-HAN5PE SCHEMBL31583195 1-[2-(4-Chlorophenyl)ethyl]-4-[1-(4-fluorophenyl)triazol-4-yl]piperidine FC1=CC=C(N2C=C(C3CCN(CCC4=CC=C(Cl)C=C4)CC3)N=N2)C=C1 Stabilizer C21H22ClFN4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-90W6NW WO2025104092A1_110 . CC1=CC=CN=C1CN1CCC(C2=CN(C3=CC=C(C(F)(F)F)C=C3)N=N2)CC1 Stabilizer C21H22F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-U5N3TS WO2025104092A1_111 . CN1C=C(CN2CCC(C3=CN(C4=CC=C(C(F)(F)F)C=C4)N=N3)CC2)C=N1 Stabilizer C19H21F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-I06HJN WO2025104092A1_112 . FC(F)(F)C1=CC=C(N2C=C(C3CCN(CC4=CN=C(C(F)(F)F)C=C4)CC3)N=N2)C=C1 Stabilizer C21H19F6N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-983EJG WO2025104092A1_113 . FC1(F)CCC(CN2C=C(C3CCN(CC4=C(C(F)(F)F)C=CC=C4)CC3)N=N2)CC1 Stabilizer C22H27F5N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-8J8SJ5 WO2025104092A1_114 . CC1=CC=CN=C1CN1CCC(C2=CN(CC3CCC(F)(F)CC3)N=N2)CC1 Stabilizer C21H29F2N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-U241SV WO2025104092A1_115 . FC1=CN=C(CN2CCC(C3=CN(CC4CCC(F)(F)CC4)N=N3)CC2)C=C1 Stabilizer C20H26F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-RO65T5 WO2025104092A1_116 . CN1C=C(Cl)C(CN2CCC(C3=CN(CC4CCC(F)(F)CC4)N=N3)CC2)=N1 Stabilizer C19H27ClF2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-1WCJST WO2025104092A1_117 . CC1=C(CN2CCC(C3=CN(CC4CCC(F)(F)CC4)N=N3)CC2)N=CN1 Stabilizer C19H28F2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-8SYFC0 WO2025104092A1_118 . CN1C=CC(CN2CCC(C3=CN(CC4CCC(F)(F)CC4)N=N3)CC2)=N1 Stabilizer C19H28F2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-OMJX5L WO2025104092A1_119 . FC(F)(F)C1=CC=CC=C1CN1CCC(C2=CN([C@H]3CC[C@H](C(F)(F)F)CC3)N=N2)CC1 Stabilizer C22H26F6N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-BJL7O0 SCHEMBL31583088 1-[2-(4-Chlorophenyl)ethyl]-4-[1-(4-chlorophenyl)triazol-4-yl]piperidine ClC1=CC=C(CCN2CCC(C3=CN(C4=CC=C(Cl)C=C4)N=N3)CC2)C=C1 Stabilizer C21H22Cl2N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-D6GGLM WO2025104092A1_120 . CC1=CC=CN=C1CN1CCC(C2=CN([C@H]3CC[C@H](C(F)(F)F)CC3)N=N2)CC1 Stabilizer C21H28F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-0IMZ87 WO2025104092A1_121 . FC(F)(F)C1=CC=CN=C1CN1CCC(C2=CN([C@H]3CC[C@H](C(F)(F)F)CC3)N=N2)CC1 Stabilizer C21H25F6N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-6HP8ZV WO2025104092A1_122 . FC1=CN=C(CN2CCC(C3=CN([C@H]4CC[C@H](C(F)(F)F)CC4)N=N3)CC2)C=C1 Stabilizer C20H25F4N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-D2BA6D WO2025104092A1_123 . CC1=C(CN2CCC(C3=CN([C@H]4CC[C@H](C(F)(F)F)CC4)N=N3)CC2)N=CN1 Stabilizer C19H27F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-Z57V2C WO2025104092A1_124 . CN1C=C(Cl)C(CN2CCC(C3=CN([C@H]4CC[C@H](C(F)(F)F)CC4)N=N3)CC2)=N1 Stabilizer C19H26ClF3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-4OV7A4 WO2025104092A1_125 . CN1C=CC(CN2CCC(C3=CN([C@H]4CC[C@H](C(F)(F)F)CC4)N=N3)CC2)=N1 Stabilizer C19H27F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-KI1O76 WO2025104092A1_126 . FC(F)(F)C1=C(CN2CCC(C3=CN([C@H]4CC[C@@H](C(F)(F)F)CC4)N=N3)CC2)C=CC=C1 Stabilizer C22H26F6N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-IOI71C WO2025104092A1_127 . CC1=C(CN2CCC(C3=CN([C@H]4CC[C@@H](C(F)(F)F)CC4)N=N3)CC2)N=CC=C1 Stabilizer C21H28F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-OI1G5I WO2025104092A1_128 . FC(F)(F)C1=C(CN2CCC(C3=CN([C@H]4CC[C@@H](C(F)(F)F)CC4)N=N3)CC2)N=CC=C1 Stabilizer C21H25F6N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-FTGZVC WO2025104092A1_129 . FC1=CC=C(CN2CCC(C3=CN([C@H]4CC[C@@H](C(F)(F)F)CC4)N=N3)CC2)N=C1 Stabilizer C20H25F4N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-T41C70 SCHEMBL31583331 1-[2-(4-Chlorophenyl)ethyl]-4-[1-[(4-fluorophenyl)methyl]triazol-4-yl]piperidine FC1=CC=C(CN2C=C(C3CCN(CCC4=CC=C(Cl)C=C4)CC3)N=N2)C=C1 Stabilizer C22H24ClFN4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-8KROCO WO2025104092A1_130 . CC1=C(CN2CCC(C3=CN([C@H]4CC[C@@H](C(F)(F)F)CC4)N=N3)CC2)N=CN1 Stabilizer C19H27F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-WMS9S9 WO2025104092A1_131 . CN1C=C(Cl)C(CN2CCC(C3=CN([C@H]4CC[C@@H](C(F)(F)F)CC4)N=N3)CC2)=N1 Stabilizer C19H26ClF3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-WD25H2 WO2025104092A1_132 . CN1C=CC(CN2CCC(C3=CN([C@H]4CC[C@@H](C(F)(F)F)CC4)N=N3)CC2)=N1 Stabilizer C19H27F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-AEVLDK WO2025104092A1_133 . CC1=CC=CC(N2C=C(C3CCN(CC4=CC=C(O)C=C4)CC3)N=N2)=C1 Stabilizer C21H24N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-SB3LI2 WO2025104092A1_134 . COC1=C(CN2CCC(C3=CN(C4=CC(C)=CC=C4)N=N3)CC2)C=CC=C1 Stabilizer C22H26N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-LSWG1Y WO2025104092A1_135 . CC1=CC=CC(N2C=C(C3CCN(CC4=C(OC(F)F)C=CC=C4)CC3)N=N2)=C1 Stabilizer C22H24F2N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-1K7OD4 WO2025104092A1_136 . CC1=CC=CC(N2C=C(C3CCN(CC4=C(F)C=C(C)C=C4)CC3)N=N2)=C1 Stabilizer C22H25FN4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-G88ESZ WO2025104092A1_137 . CC1=CC=C(CN2CCC(C3=CN(C4=CC(C)=CC=C4)N=N3)CC2)C(C)=C1 Stabilizer C23H28N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-68660A WO2025104092A1_138 . CC1=CC=CC(N2C=C(C3CCN(CC4=C(F)C=CC=C4)CC3)N=N2)=C1 Stabilizer C21H23FN4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-BC4OZQ WO2025104092A1_139 . CC1=CC=CC(N2C=C(C3CCN(CC4=C(F)C=CC=C4F)CC3)N=N2)=C1 Stabilizer C21H22F2N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-QPX4RT WO2025104092A1_140 . COC1=CC=CC(CN2CCC(C3=CN(C4=CC(C)=CC=C4)N=N3)CC2)=C1 Stabilizer C22H26N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-QGDHIU WO2025104092A1_141 . CC1=CC=CC(N2C=C(C3CCN(CC4=CC=C(N(C)C)C=C4)CC3)N=N2)=C1 Stabilizer C23H29N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-NMU2EC WO2025104092A1_142 . CC1=CC=CC(N2C=C(C3CCN(CC4=CC(C#N)=CC=C4)CC3)N=N2)=C1 Stabilizer C22H23N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-70LW4Y WO2025104092A1_143 . COC1=NC=CC=C1CN1CCC(C2=CN(C3=CC(C)=CC=C3)N=N2)CC1 Stabilizer C21H25N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-WB0AOY WO2025104092A1_144 . CC1=CC=CC(N2C=C(C3CCN(CC4=NC=CC=C4C)CC3)N=N2)=C1 Stabilizer C21H25N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-GGN9S5 WO2025104092A1_145 . CC1=CC=CC(N2C=C(C3CCN(CC4=NC=C(Cl)C=C4)CC3)N=N2)=C1 Stabilizer C20H22ClN5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-AVTRXO WO2025104092A1_146 . CC1=CC=CC(N2C=C(C3CCN(CC4=C(C)NC=N4)CC3)N=N2)=C1 Stabilizer C19H24N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-26643S WO2025104092A1_147 . CC1=CC=CC(N2C=C(C3CCN(CC4=COC=C4)CC3)N=N2)=C1 Stabilizer C19H22N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-5U5W95 WO2025104092A1_148 . CC1=CC=CC(N2C=C(C3CCN(CC4=CC=CN4)CC3)N=N2)=C1 Stabilizer C19H23N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-4TBKO2 WO2025104092A1_149 . CC1=CC=CC(N2C=C(C3CCN(CC4=CSC(C)=N4)CC3)N=N2)=C1 Stabilizer C19H23N5S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-QQ9F5M WO2025104092A1_150 . COC1=CC(C)=C(CN2CCC(C3=CN(C4=CC=C(C#N)C=C4)N=N3)CC2)C=C1 Stabilizer C23H25N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-9J6QKJ WO2025104092A1_151 . COC1=CC=CC=C1CN1CCC(C2=CN(C3=CC=C(C#N)C=C3)N=N2)CC1 Stabilizer C22H23N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-ASRKE1 WO2025104092A1_152 . CC1=CC=CC=C1CN1CCC(C2=CN(C3=CC=C(C#N)C=C3)N=N2)CC1 Stabilizer C22H23N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-N1TE43 WO2025104092A1_153 . N#CC1=CC=C(N2C=C(C3CCN(CC4=CC=CC=C4C(F)(F)F)CC3)N=N2)C=C1 Stabilizer C22H20F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-ZUFGJZ WO2025104092A1_154 . COC1=CC=CC(OC)=C1CN1CCC(C2=CN(C3=CC=C(C#N)C=C3)N=N2)CC1 Stabilizer C23H25N5O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-VOV0V8 WO2025104092A1_155 . COC1=C(F)C=C(CN2CCC(C3=CN(C4=CC=C(C#N)C=C4)N=N3)CC2)C=C1 Stabilizer C22H22FN5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-PTMZ0R WO2025104092A1_156 . CN(C)C1=CC=C(CN2CCC(C3=CN(C4=CC=C(C#N)C=C4)N=N3)CC2)C=C1 Stabilizer C23H26N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-ZGSBMA WO2025104092A1_157 . COC1=NC(CN2CCC(C3=CN(C4=CC=C(C#N)C=C4)N=N3)CC2)=CC=C1 Stabilizer C21H22N6O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-ZZOS4I WO2025104092A1_158 . N#CC1=CC=C(N2C=C(C3CCN(CC4=CC=C(F)C=N4)CC3)N=N2)C=C1 Stabilizer C20H19FN6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-JBTMQD WO2025104092A1_159 . CC1=NC(CN2CCC(C3=CN(C4=CC=C(C#N)C=C4)N=N3)CC2)=CS1 Stabilizer C19H20N6S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-V3GVHZ WO2025104092A1_160 . FC(F)(F)C1=C(CN2CCC(C3=CN(C4CCCCC4)N=N3)CC2)C=CC=C1 Stabilizer C21H27F3N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-H2ZQUN WO2025104092A1_161 . FC(F)(F)C1=C(CN2CCC(C3=CN(C4CCCCC4)N=N3)CC2)N=CC=C1 Stabilizer C20H26F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-KOGISH WO2025104092A1_162 . CC1=C(CN2CCC(C3=CN(C4CCCCC4)N=N3)CC2)N=CC=C1 Stabilizer C20H29N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-ZURRW8 WO2025104092A1_163 . FC1=CC=C(CN2CCC(C3=CN(C4CCCCC4)N=N3)CC2)N=C1 Stabilizer C19H26FN5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-ESBFXW WO2025104092A1_164 . CN1C=C(Cl)C(CN2CCC(C3=CN(C4CCCCC4)N=N3)CC2)=N1 Stabilizer C18H27ClN6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-K1DP3F WO2025104092A1_165 . CN1C=CC(CN2CCC(C3=CN(C4CCCCC4)N=N3)CC2)=N1 Stabilizer C18H28N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-QY2BKA WO2025104092A1_166 . CC1=C(CN2CCC(C3=CN(C4CCCCC4)N=N3)CC2)N=CN1 Stabilizer C18H28N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-BU8DRU WO2025104092A1_167 . O=S1(=O)CCC(N2C=C(C3CCN(CC4=C(C(F)(F)F)C=CC=C4)CC3)N=N2)CC1 Stabilizer C20H25F3N4O2S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-SL8IDN WO2025104092A1_168 . O=S1(=O)CCC(N2C=C(C3CCN(CC4=C(C(F)(F)F)C=CC=N4)CC3)N=N2)CC1 Stabilizer C19H24F3N5O2S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-IPGEPH WO2025104092A1_169 . CC1=C(CN2CCC(C3=CN(C4CCS(=O)(=O)CC4)N=N3)CC2)N=CC=C1 Stabilizer C19H27N5O2S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-XCB3DP SCHEMBL31583266 4-[1-(3,4-Difluorophenyl)triazol-4-yl]-1-[2-[4-(trifluoromethyl)phenyl]ethyl]piperidine FC1=C(F)C=C(N2C=C(C3CCN(CCC4=CC=C(C(F)(F)F)C=C4)CC3)N=N2)C=C1 Stabilizer C22H21F5N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-XV55QL WO2025104092A1_170 . CN1C=C(Cl)C(CN2CCC(C3=CN(C4CCS(=O)(=O)CC4)N=N3)CC2)=N1 Stabilizer C17H25ClN6O2S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-KSQW3Z WO2025104092A1_171 . CC1=C(CN2CCC(C3=CN(C4CCOCC4)N=N3)CC2)C=CC=C1 Stabilizer C20H28N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-8BRYNX WO2025104092A1_172 . CC1=C(CN2CCC(C3=CN(C4CCOCC4)N=N3)CC2)N=CC=C1 Stabilizer C19H27N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-K2ZRQK WO2025104092A1_173 . CC1=CC=C(CN2CCC(C3=CN(C4CCOCC4)N=N3)CC2)N=C1 Stabilizer C19H27N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-88AL6I WO2025104092A1_174 . CC1=CC=CN=C1CN1CCC(C2=CN(CC3CCOCC3)N=N2)CC1 Stabilizer C20H29N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-EFR816 WO2025104092A1_175 . CN1C=C(Cl)C(CN2CCC(C3=CN(CC4CCOCC4)N=N3)CC2)=N1 Stabilizer C18H27ClN6O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-RIQW6S WO2025104092A1_176 . CC1=C(CN2CCC(C3=CN(CC4CCOCC4)N=N3)CC2)N=CN1 Stabilizer C18H28N6O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-WMRV2K WO2025104092A1_177 . COC1=C(CN2CCC(C3=CN(C4=CN=CC=C4)N=N3)CC2)C=CC=C1 Stabilizer C20H23N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-5R49LG WO2025104092A1_178 . CC1=C(CN2CCC(C3=CN(C4=CN=CC=C4)N=N3)CC2)C=CC=C1 Stabilizer C20H23N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-I6E2S8 WO2025104092A1_179 . CC1=C(F)C=CC=C1CN1CCC(C2=CN(C3=CN=CC=C3)N=N2)CC1 Stabilizer C20H22FN5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-41OB6N SCHEMBL31583087 1-[2-(3,4-Difluorophenyl)ethyl]-4-[1-(3,4-difluorophenyl)triazol-4-yl]piperidine FC1=C(F)C=C(CCN2CCC(C3=CN(C4=CC(F)=C(F)C=C4)N=N3)CC2)C=C1 Stabilizer C21H20F4N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-Z7CHU8 WO2025104092A1_180 . CC1=C(CN2CCC(C3=CN(C4=CN=CC=C4)N=N3)CC2)N=CC=C1 Stabilizer C19H22N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-O3JWQE WO2025104092A1_181 . COC1=C(N2C=C(C3CCN(CC4=CC=C(C(F)(F)F)C=C4)CC3)N=N2)C=CC=C1 Stabilizer C22H23F3N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-4MQ5RZ WO2025104092A1_182 . COC1=CC=C(CN2CCC(C3=CN(C4=C(OC)C=CC=C4)N=N3)CC2)C=C1 Stabilizer C22H26N4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-V04WZ6 WO2025104092A1_183 . COC1=NC=C(CN2CCC(C3=CN(C4=C(OC)C=CC=C4)N=N3)CC2)C=C1 Stabilizer C21H25N5O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-NH3WO1 WO2025104092A1_184 . CC1=C(CN2CCC(O)(C3=CN(C4=CC=CC(Cl)=C4)N=N3)CC2)C=CC=C1 Stabilizer C21H23ClN4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-10KDRG WO2025104092A1_185 . OC1(C2=CN(C3=CC=CC(Cl)=C3)N=N2)CCN(CC2=C(F)C=CC=C2F)CC1 Stabilizer C20H19ClF2N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-MHD8SM WO2025104092A1_186 . CC1=NC(CN2CCC(O)(C3=CN(C4=CC(Cl)=CC=C4)N=N3)CC2)=CS1 Stabilizer C18H20ClN5OS Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-B5LU0K WO2025104092A1_187 . CC1=CC=CN=C1CN1CCC(O)(C2=CN(C3=CC(Cl)=CC=C3)N=N2)CC1 Stabilizer C20H22ClN5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-L6NJDV WO2025104092A1_188 . COC1(C2=CN(C3=CC(Cl)=CC=C3)N=N2)CCN(CC2=C(F)C=CC=C2F)CC1 Stabilizer C21H21ClF2N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-5NSJ2N WO2025104092A1_189 . COC1(C2=CN(C3=CC(Cl)=CC=C3)N=N2)CCN(CC2=CC=CC=C2C)CC1 Stabilizer C22H25ClN4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-OMOL6A SCHEMBL31583437 4-[1-(3,4-Difluorophenyl)triazol-4-yl]-1-[2-[3-(trifluoromethyl)phenyl]ethyl]piperidine FC1=C(F)C=C(N2C=C(C3CCN(CCC4=CC(C(F)(F)F)=CC=C4)CC3)N=N2)C=C1 Stabilizer C22H21F5N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-Z2Y84K WO2025104092A1_190 . COC1(C2=CN(C3=CC(Cl)=CC=C3)N=N2)CCN(CC2=C(C)N=CN2)CC1 Stabilizer C19H23ClN6O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-RCDR29 WO2025104092A1_191 . CC1=CC=CC(N2C=C(C3(O)CCN(CC4=CC=CC=C4F)CC3)N=N2)=C1 Stabilizer C21H23FN4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-NV5KGO WO2025104092A1_192 . CC1=CC=CC(N2C=C(C3(O)CCN(CC4=C(F)C=CC=C4F)CC3)N=N2)=C1 Stabilizer C21H22F2N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-TK6OZL WO2025104092A1_193 . CC1=CC=CC(N2C=C(C3(O)CCN(CC4=CC=CC(C#N)=C4)CC3)N=N2)=C1 Stabilizer C22H23N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-3RME45 WO2025104092A1_194 . CC1=CC=CC(N2C=C(C3(O)CCN(CC4=CC=CC=C4C)CC3)N=N2)=C1 Stabilizer C22H26N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-O68ZHW WO2025104092A1_195 . CC1=CC=CC(N2C=C(C3(O)CCN(CC4=C(C(F)(F)F)C=CC=C4)CC3)N=N2)=C1 Stabilizer C22H23F3N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-AEBUMP WO2025104092A1_196 . COC1=CC=CC=C1CN1CCC(O)(C2=CN(C3=CC(C)=CC=C3)N=N2)CC1 Stabilizer C22H26N4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-8NAJ55 WO2025104092A1_197 . COC1=CC(CN2CCC(O)(C3=CN(C4=CC(C)=CC=C4)N=N3)CC2)=CC=C1 Stabilizer C22H26N4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-7B4IWO WO2025104092A1_198 . CC1=CC=CC(N2C=C(C3(O)CCN(CC4=CC=CC=C4OC(F)F)CC3)N=N2)=C1 Stabilizer C22H24F2N4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-15RPCR WO2025104092A1_199 . CC1=CC=CC(N2C=C(C3(O)CCN(CC4=NC=CC=C4C)CC3)N=N2)=C1 Stabilizer C21H25N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-W2Z6GB SCHEMBL31583547 1-(1,3-Benzodioxol-5-ylmethyl)-4-[1-[(3-fluorophenyl)methyl]triazol-4-yl]piperidine FC1=CC(CN2C=C(C3CCN(CC4=CC=C5OCOC5=C4)CC3)N=N2)=CC=C1 Stabilizer C22H23FN4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-9LN9I9 SCHEMBL31583582 2-Methoxy-4-[2-[4-(1-phenyltriazol-4-yl)piperidin-1-yl]ethyl]pyridine COC1=NC=CC(CCN2CCC(C3=CN(C4=CC=CC=C4)N=N3)CC2)=C1 Stabilizer C21H25N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-O7SN7D WO2025104092A1_200 . COC1=CC=CC(N2C=C(C3CCN(CC4=C(OC(F)F)C=CC=C4)CC3)N=N2)=C1 Stabilizer C22H24F2N4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-MW2PD4 WO2025104092A1_201 . COC1=CC=CC(N2C=C(C3CCN(CC4=CC=CC=C4C)CC3)N=N2)=C1 Stabilizer C22H26N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-QQBISK WO2025104092A1_202 . COC1=CC=CC(N2C=C(C3CCN(CC4=C(F)C=CC=C4F)CC3)N=N2)=C1 Stabilizer C21H22F2N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-IJ2XWT SCHEMBL31583469 1-[2-(2-Fluorophenyl)ethyl]-4-[1-[4-(trifluoromethyl)phenyl]triazol-4-yl]piperidine FC1=C(CCN2CCC(C3=CN(C4=CC=C(C(F)(F)F)C=C4)N=N3)CC2)C=CC=C1 Stabilizer C22H22F4N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-9TCHA7 WO2025104092A1_204 . CC1=CC(N2C=C(C3CCN(CCC4=NC=CC=C4)CC3)N=N2)=CC=C1 Stabilizer C21H25N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-V3K7KH WO2025104092A1_205 . COC1=C(N2C=C(C3CCN(CCC4=CC=CC(C(F)(F)F)=C4)CC3)N=N2)C=CC=C1 Stabilizer C23H25F3N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-3EL5XD WO2025104092A1_206 . CC1=CC(N2C=C(C3CCN(CCC4=CCC(O)C=C4)CC3)N=N2)=CC=C1 Stabilizer C22H28N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-GR6IWI SCHEMBL31583123 2-[4-[1-(3-Methylphenyl)triazol-4-yl]piperidin-1-yl]-1-[4-(trifluoromethoxy)phenyl]ethanol CC1=CC(N2C=C(C3CCN(CC(O)C4=CC=C(OC(F)(F)F)C=C4)CC3)N=N2)=CC=C1 Stabilizer C23H25F3N4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-0KCNQY SCHEMBL31583787 4-[2-[4-(1-Benzyltriazol-4-yl)piperidin-1-yl]ethyl]-2-methoxypyridine COC1=NC=CC(CCN2CCC(C3=CN(CC4=CC=CC=C4)N=N3)CC2)=C1 Stabilizer C22H27N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-EM7XDL WO2025104092A1_210 . COC1=CC=C(C(O)CN2CCC(C3=CN(C4=CC=CC(C)=C4)N=N3)CC2)C=C1F Stabilizer C23H27FN4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-GA4RU0 SCHEMBL31583322 2-[4-[1-(3-Methylphenyl)triazol-4-yl]piperidin-1-yl]-1-phenylethanol CC1=CC(N2C=C(C3CCN(CC(O)C4=CC=CC=C4)CC3)N=N2)=CC=C1 Stabilizer C22H26N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-EMPMPF WO2025104092A1_212 . COC1=CC(C(O)CN2CCC(C3=CN(C4=CC=CC(C)=C4)N=N3)CC2)=CC=C1 Stabilizer C23H28N4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-M3I4JA WO2025104092A1_213 . COC1=CC=C(C(O)CN2CCC(C3=CN(C4=CN=CC=C4)N=N3)CC2)C=C1 Stabilizer C21H25N5O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-2EFE5T WO2025104092A1_214 . OC(CN1CCC(C2=CN(C3CCOCC3)N=N2)CC1)C1=CC=C(Cl)C=C1 Stabilizer C20H27ClN4O2 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-UQ05UU WO2023193760-A1_GS-800 . Cc1nc(-c2cn([C@H]3C[C@H](CNc4ccc5c(c4)CN([C@H]4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)ccc1F Degrader C30H31FN6O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-HS8SF4 WO2025104092A1_215 . CC1=CC=C(C(O)CN2CCC(C3=CN(C4=CC=C(C#N)C=C4)N=N3)CC2)C=C1 Stabilizer C23H25N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-HA4LYH WO2025104092A1_216 . CC1=CC=CC(N2C=C(C3(F)CCN(CC4=CC=CC=C4F)CC3)N=N2)=C1 Stabilizer C21H22F2N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-E82NIN WO2023193760-A1_GS-802 . O=C1CCC(N2Cc3cc(NC[C@H]4C[C@H](n5cc(-c6ccc(F)c(C(F)F)n6)c(C6CC6)n5)C4)ccc3C2=O)C(=O)N1 Degrader C30H29F3N6O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-073UPN WO2025104092A1_217 . CC1=CC=CC(N2C=C(C3(F)CCN(CC4=CC=CC=C4C)CC3)N=N2)=C1 Stabilizer C22H25FN4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-Y0Y2KP WO2025104092A1_218 . CC1=CC=CC(N2C=C(C3(F)CCN(CC4=C(F)C=CC=C4F)CC3)N=N2)=C1 Stabilizer C21H21F3N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-Y1XEVO WO2023193760-A1_GS-803 . O=C1CCC(N2Cc3cc(NC[C@H]4C[C@H](n5cc(-c6ccc(F)c(C(F)(F)F)n6)c(C6CC6)n5)C4)ccc3C2=O)C(=O)N1 Degrader C30H28F4N6O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-W6WHBH WO2023193760-A1_GS-804 . Nc1nc(-c2cn([C@H]3C[C@H](CNc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)ccc1F Degrader C29H30FN7O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-NU5UL8 SCHEMBL31583260 1-[2-Fluoro-2-[4-(trifluoromethoxy)phenyl]ethyl]-4-[1-(3-methylphenyl)triazol-4-yl]piperidine CC1=CC(N2C=C(C3CCN(CC(F)C4=CC=C(OC(F)(F)F)C=C4)CC3)N=N2)=CC=C1 Stabilizer C23H24F4N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-PW86MJ SCHEMBL31583190 4-[2-[4-[1-[(3,4-Difluorophenyl)methyl]triazol-4-yl]piperidin-1-yl]ethyl]-2-methoxypyridine COC1=NC=CC(CCN2CCC(C3=CN(CC4=CC(F)=C(F)C=C4)N=N3)CC2)=C1 Stabilizer C22H25F2N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-1BFKBX WO2025104092A1_23 . FC1=C(F)C=C(CCN2CCC(C3=CN(C4=CC=CC=C4)N=N3)CC2)C=C1 Stabilizer C21H22F2N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-UJRVIE WO2025104092A1_24 . FC1=C(F)C=C(CCN2CCC(C3=CN(CC4=CC=CC=C4)N=N3)CC2)C=C1 Stabilizer C22H24F2N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-9LNHC5 WO2025104092A1_25 . FC1=C(F)C=C(CCN2CCC(C3=CN(CC4=CC(F)=C(F)C=C4)N=N3)CC2)C=C1 Stabilizer C22H22F4N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-H849GV SCHEMBL31583221 1-(2-Phenylethyl)-4-(1-phenyltriazol-4-yl)piperidine C1=CC=C(CCN2CCC(C3=CN(C4=CC=CC=C4)N=N3)CC2)C=C1 Stabilizer C21H24N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-Z5RKPL WO2023193760-A1_GS-809 . Cc1nc(-c2cn([C@H]3C[C@H](CNc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)c(F)cc1F Degrader C30H30F2N6O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-0TLOAR WO2023193760-A1_GS-810 . Nc1cccc(-c2cn([C@H]3C[C@H](CNc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)n1 Degrader C29H31N7O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-V98LNU SCHEMBL31583452 4-(1-Benzyltriazol-4-yl)-1-(2-phenylethyl)piperidine C1=CC=C(CCN2CCC(C3=CN(CC4=CC=CC=C4)N=N3)CC2)C=C1 Stabilizer C22H26N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-24T5C2 SCHEMBL31583075 4-[1-[(3,4-Difluorophenyl)methyl]triazol-4-yl]-1-(2-phenylethyl)piperidine FC1=C(F)C=C(CN2C=C(C3CCN(CCC4=CC=CC=C4)CC3)N=N2)C=C1 Stabilizer C22H24F2N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-BBGRBL WO2023193760-A1_GS-811 . CNc1cccc(-c2cn([C@H]3C[C@H](CNc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)nc2C2CC2)n1 Degrader C30H33N7O3 GSPT1 P15170 CRBN WO-2023193760-A1 TPD-C282WP WO2025104092A1_29 . FC1=C(F)C=C(N2C=C(C3CCN(CCC4=CC=CC=C4)CC3)N=N2)C=C1 Stabilizer C21H22F2N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-OLF8KQ SCHEMBL31583274 4-[1-[(3-Fluorophenyl)methyl]triazol-4-yl]-1-[(2-methylphenyl)methyl]piperidine CC1=CC=CC=C1CN1CCC(C2=CN(CC3=CC=CC(F)=C3)N=N2)CC1 Stabilizer C22H25FN4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-S64R2I WO2025104092A1_30 . CC1=CC=C(CCN2CCC(C3=CN(C4=CC(F)=C(F)C=C4)N=N3)CC2)C=C1 Stabilizer C22H24F2N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-02Q24Y WO2025104092A1_301 . O=S1(=O)CCC(N2C=C(C3CCN(CC4=NC=C(F)C=C4)CC3)N=N2)CC1 Stabilizer C18H24FN5O2S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-4JY5QZ WO2025104092A1_303 . FC1=CN=C(CN2CCC(C3=CN(CC4CCOCC4)N=N3)CC2)C=C1 Stabilizer C19H26FN5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-WG97T3 WO2025104092A1_306 . CC1=CC=CC(N2C=C(C3CCN(CC4=CN=CO4)CC3)N=N2)=C1 Stabilizer C18H21N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-92X0U3 WO2025104092A1_308 . N#CC1=CC(CN2CCC(C3=CN(C4=CN=CC=C4)N=N3)CC2)=CC=C1 Stabilizer C20H20N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-8I2DXG WO2025104092A1_309 . COC1=C(N2C=C(C3CCN(CC4=NN(C)C=C4Cl)CC3)N=N2)C=CC=C1 Stabilizer C19H23ClN6O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-71XFM2 WO2025104092A1_31 . COC1=CC(CCN2CCC(C3=CN(C4=CC(F)=C(F)C=C4)N=N3)CC2)=CC=N1 Stabilizer C21H23F2N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-NF7U9A WO2025104092A1_310 . CC1=CC=CC(N2C=C(C3(O)CCN(CC4=CC=CC=N4)CC3)N=N2)=C1 Stabilizer C20H23N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-YHR1K2 WO2025104092A1_311 . CC1=NNC(CN2CCC(C3=CN([C@H]4CC[C@@H](C(F)(F)F)CC4)N=N3)CC2)=C1 Stabilizer C19H27F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-AFOH3W WO2025104092A1_312 . CC1=NNC(CN2CCC(C3=CN(C4CCCCC4)N=N3)CC2)=C1 Stabilizer C18H28N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-5AJZZF WO2025119279A1_1 . O=C1CCC(N2C(=O)C3=C(C2=O)/C(NCC2=CC=NC(NCC4CCCCC4)=C2F)=C\C=C/3)C(=O)N1 Degrader C26H28FN5O4 IKZF1 Q13422 CRBN WO-2025119279-A1 TPD-4SNPKN WO2025119279A1_2 . O=C1CCC(N2CC3=C(/C=C\C=C/3OCC3=CC=NC(NC[C@H]4CC[C@H](C5=NC6=C(/N=C\C=C/6)S5)CC4)=C3F)C2=O)C(=O)N1 Degrader C32H31FN6O4S IKZF1 Q13422 CRBN WO-2025119279-A1 TPD-M1X10P WO2025119279A1_3 . O=C1CCC(N2CC3=C(/C=C\C=C/3NCC3=CC=NC(NC[C@H]4CC[C@H](C5=NC6=C(/N=C\C=C/6)S5)CC4)=C3F)C2=O)C(=O)N1 Degrader C32H32FN7O3S IKZF1 Q13422 CRBN WO-2025119279-A1 TPD-WOWXB6 WO2025119279A1_4 . COC1=N/C2=C(\C=C/1)N=C([C@H]1CC[C@H](CNC3=C(F)C(CO/C4=C/C=C\C5=C4CN(C4CCC(=O)NC4=O)C5=O)=CC=N3)CC1)S2 Degrader C33H33FN6O5S IKZF1 Q13422 CRBN WO-2025119279-A1 TPD-V3BOVZ WO2025129172A1_10 . CC(C)(C)N/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3=O)/N=C2/OC=CN12 Degrader C22H21N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-TUX5I8 WO2025129172A1_100 . CC(C)(C)CC(C)(C)NC1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)N=C2/C=C\C3=C(OCC3)N21 Degrader C30H33N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-P1375F WO2025129172A1_101 . CC(C)(C)CC(C)(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)/N=C2/C=CC=C(C3=CC=CC=C3)N21 Degrader C34H35N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-WZJIYM WO2025129172A1_102 . CCC(C)(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=C(C)N21 Degrader C26H29N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-3XSV65 WO2025129172A1_103 . CC1=CC=C/C2=N/C(C3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)=C(/NCCC3=CC=CC=C3)N12 Degrader C29H27N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-WD14LI WO2025129172A1_104 . CCCCN/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=C(C)N21 Degrader C25H27N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-CB73YM WO2025129172A1_105 . CC1=CC=C/C2=N/C(C3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)=C(/NC(C)C3=CC=CC=C3)N12 Degrader C29H27N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-MM561R WO2025129172A1_106 . CC1=CC=C/C2=N/C(C3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)=C(/NC3CCCCCC3)N12 Degrader C28H31N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-KRHDMS WO2025129172A1_107 . CC1=CC(C)=C(N/C2=C(C3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)/N=C3/C=CC=C(C)N32)C(C)=C1 Degrader C30H29N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-FN50XT WO2025129172A1_108 . O=C1CCC(N2C(=O)C3=CC=C(C4=C(\NCC5=CC=CC=C5)N5C=CC=C\C5=N\4)C=C3C2=O)C(=O)N1 Degrader C27H21N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-005QZQ WO2025129172A1_109 . CC1=CC(C)=C(N/C2=C(C3=C\C4=C(/C=C\3)C(=O)N(C3CCC(=O)NC3=O)C4=O)/N=C3/C=CC=CN32)C(C)=C1 Degrader C29H25N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-RWAHFB WO2025129172A1_11 . O=C1CCC(N2CC3=C(/C=C\C(C4=C(/NC5CCCC5)N5C=CC=N/C5=N/4)=C/3)C2=O)C(=O)N1 Degrader C24H24N6O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-AE0M3J WO2025129172A1_110 . CC(N/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3=O)/N=C2/C=CC=CN21)C1=CC=CC=C1 Degrader C28H23N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-JHBSGM WO2025129172A1_111 . O=C1CCC(N2C(=O)C3=C(C=C(C4=C(\NCCC5=CC=CC=C5)N5C=CC=C\C5=N\4)C=C3)C2=O)C(=O)N1 Degrader C28H23N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-N4VUA6 WO2025129172A1_112 . CCC(C)(C)N/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3=O)/N=C2/C=CC=CN21 Degrader C25H25N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-NIW5JA WO2025129172A1_113 . CC(C)(C)CCN/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3=O)/N=C2/C=CC=CN21 Degrader C26H27N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-W0BKIR WO2025129172A1_114 . COC1=CC=C(CNC2=C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4=O)N=C3C=CC=CN32)C=C1 Degrader C28H23N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-K1WZLR WO2025129172A1_115 . CC1=CC=C(CN/C2=C(C3=C\C4=C(/C=C\3)C(=O)N(C3CCC(=O)NC3=O)C4=O)/N=C3/C=CC=CN32)C=C1 Degrader C28H23N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-ONSH3L WO2025129172A1_116 . CC(C)(C)N/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3)/N=C2/SC3=C(C=CC(Cl)=C3)N12 Degrader C26H24ClN5O3S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-TPJEYR WO2025129172A1_117 . CC(C)(C)N/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3)/NC2SC3=C(C=CC(Br)=C3)N12 Degrader C26H26BrN5O3S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-7247WU WO2025129172A1_118 . CC(C)(C)N/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3)/N=C2/SC3=C(C=CC(C(C)(C)C)=C3)N12 Degrader C30H33N5O3S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-645C8U WO2025129172A1_119 . CC(C)(C)N/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3)/N=C2/SC3=C(C=CC(OC(F)(F)F)=C3)N12 Degrader C27H24F3N5O4S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-OQS5KS WO2025129172A1_12 . CC(C)(C)N/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3)/N=C2/C=C\C3=C(C=CC=C3)N21 Degrader C28H27N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-7SULNY WO2025129172A1_120 . COC1=CC2=C(C=C1)S/C1=N/C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)=C(/NC(C)(C)C)N21 Degrader C27H27N5O4S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-Z9XSCM WO2025129172A1_121 . CC1=CC=CC2=C1N1/C(NC(C)(C)C)=C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)\N=C/1S2 Degrader C27H27N5O3S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-2RZIVN WO2025129172A1_122 . CC1=CC=CC2=C1S/C1=N/C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)=C(/NC(C)(C)C)N21 Degrader C27H27N5O3S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-H81UNK WO2025129172A1_123 . CC(C)(C)N/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3)/N=C2/SC3=C(C=CC=C3)N12 Degrader C26H25N5O3S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-5IIVAN WO2025129172A1_124 . N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=CN21 Degrader C20H17N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-1GFLU0 WO2025129172A1_125 . O=C1CCC(N2CC3=C(/C=C\C(C4=C(/NC(=O)CC5=CC=CC=C5)N5C=CC=C/C5=N/4)=C/3)C2=O)C(=O)N1 Degrader C28H23N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-8EUASZ WO2025129172A1_126 . O=C1CCC(N2CC3=C(/C=C\C(C4=C(/NC(=O)C5=CC=CC=C5)N5C=CC=C/C5=N/4)=C/3)C2=O)C(=O)N1 Degrader C27H21N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-IDZ4L1 WO2025129172A1_127 . O=C1CCC(N2CC3=C(/C=C\C(C4=C(/NC(=O)C5CCCCC5)N5C=CC=C/C5=N/4)=C/3)C2=O)C(=O)N1 Degrader C27H27N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-VIF5JE WO2025129172A1_128 . O=C1CCC(N2CC3=CC(C4=C(\NC5=CC=CC=C5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C26H21N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-D6VBT9 WO2025129172A1_129 . O=C1CCC(N2CC3=CC(C4=C(\NC5=CC6=C(C=C5)/N=C\C=N/6)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C28H21N7O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-TB7D6I WO2025129172A1_13 . CC(C)(C)CC(C)(C)N/C1=C(C2=CC3=C(C=C2)C(=O)N(C2CCC(=O)NC2=O)C3=O)/N=C2/C3=C(C=CC=C3)/C=C\N21 Degrader C32H33N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-W3PGEH WO2025129172A1_130 . O=C1CCC(N2CC3=CC(C4=C(\NC5=C6OCCOC6=CC=C5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C28H23N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-G83742 WO2025129172A1_131 . NC1=C(C(=O)C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)N2C=CC=CC2=N1 Degrader C21H17N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-A4GKSC WO2025129172A1_132 . O=C1CCC(N2CC3=C\C(C4=C(/Cl)N5C=CC=C/C5=N/4)=C/C=C\3C2=O)C(=O)N1 Degrader C20H15ClN4O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-9L90O5 WO2025129172A1_14 . O=C1CCC(N2C(=O)C3=C(C=C(C4=C(\NC56CC7CC(CC(C7)C5)C6)N5N=CS\C5=N\4)C=C3)C2=O)C(=O)N1 Degrader C27H26N6O4S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-PO1F7D WO2025129172A1_15 . O=C1CCC(N2CC3=CC(C4=C(\NC5=CC6=C(C=C5)/C=C\C=C/6)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C30H23N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-41BB04 WO2025129172A1_16 . O=C1CCC(N2CC3=CC(C4=C(\NCC5=CC=CC=C5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C27H23N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-QK6FHZ WO2025129172A1_17 . CC(C)(C)CC(C)(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=CN21 Degrader C28H33N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-M6CR00 WO2025129172A1_18 . O=C1CCC(N2CC3=CC(C4=C(\NC5CC5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C23H21N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-CQZBY0 WO2025129172A1_19 . O=C1CCC(N2CC3=CC(C4=C(\NC5CCCC5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C25H25N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-IUR0W1 SCHEMBL27351710 2-(2,6-dioxopiperidin-3-yl)-3-oxo-2,3-dihydro-1H-isoindole-5-carbaldehyde; 2866307-09-5; 898-807-3; 2-(2,6-DIOXOPIPERIDIN-3-YL)-3-OXOISOINDOLINE-5-CARBALDEHYDE; SCHEMBL30786880; SCHEMBL30786881; MFCD35078060; AT36150; EN300-26866520; Z4487047988; 2-(2,6-dioxo-3-piperidyl)-3-oxo-isoindoline-5-carbaldehyde O=CC1=CC=C2CN(C3CCC(=O)NC3=O)C(=O)C2=C1 Degrader C14H12N2O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-WPFH4C WO2025129172A1_20 . COC(=O)CN/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=CN21 Degrader C23H21N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-N3YPBR WO2025129172A1_21 . CC(C)(C)OC(=O)CN/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=CN21 Degrader C26H27N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-2Z7CNI WO2025129172A1_22 . O=C1CCC(N2CC3=CC(C4=C(\NCC(=O)N5CCCC5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C26H26N6O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-KBHUF3 WO2025129172A1_23 . O=C1CCC(N2CC3=CC(C4=C(\NCCN5CCOCC5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C26H28N6O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-2K4LU7 WO2025129172A1_24 . CC(C)(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)/N=C2/C=CC=CN21 Degrader C24H23N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-E9GSXB WO2025129172A1_25 . O=C1CCC(N2C(=O)C3=CC=C(C4/N=C5/C=CC=CN5C4NC4=CC5=C(C=C4)OCCO5)C=C3C2=O)C(=O)N1 Degrader C28H23N5O6 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-6S5H0H WO2025129172A1_26 . CC(C)(C)N/C1=C(C2=C\C=C3\CN(C4CCC(=O)NC4=O)C(=O)/C3=C\2)/N=C2/C=CC=CN21 Degrader C24H25N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-H7DU5O WO2025129172A1_27 . O=C1CCC(N2CC3=C/C=C(C4=C(\NC5=CC=C6OCCOC6=C5)N5C=CC=C/C5=N/4)\C=C\3C2=O)C(=O)N1 Degrader C28H23N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-ZXT98S WO2025129172A1_28 . CC(C)(C)N/C1=C(C2=C3CN(C4CCC(=O)NC4=O)C(=O)C3=CC=C2)/N=C2/C=CC=CN21 Degrader C24H25N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-1AD6D4 WO2025129172A1_29 . O=C1CCC(N2CC3=CC(C4=C(\NC5CC6CCCCC5CC6)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C30H33N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-5Q2JEC 2642231-76-1 2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindole-4-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindole-4-carbaldehyde; 898-911-9; 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-4-carbaldehyde; 2-(2,6-DIOXO-3-PIPERIDYL)-1-OXOISOINDOLINE-4-CARBALDEHYDE; SCHEMBL24967103; MFCD35076641; SY419316; DB-407988; H27172; EN300-27776907; Z3210767118; 2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindole-4-carbaldehyde O=CC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Degrader C14H12N2O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-SHU7VC WO2025129172A1_30 . O=C1CCC(N2CC3=CC(C4=C(\NC5CCCCCC5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C27H29N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-EX00XO WO2025129172A1_31 . O=C1CCC(N2CC3=CC(C4=C(\NC5CCCCC5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C26H27N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-GIQPTN WO2025129172A1_32 . CCCCN/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=CN21 Degrader C24H25N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-YVWFR5 WO2025129172A1_33 . COCCN/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=CN21 Degrader C23H23N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-AC9J21 WO2025129172A1_34 . O=C1CCC(N2CC3=CC(C4=C(\NCC5=CN=CC=C5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C26H22N6O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-UVURQL WO2025129172A1_35 . CC(C)(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/N=CC=CN21 Degrader C23H24N6O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-Q9SI7Y WO2025129172A1_36 . CC(C)(C)NC1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)N=C2C=CC=NN21 Degrader C23H24N6O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-80WFOT WO2025129172A1_37 . O=C1CCC(N2C(=O)C3=CC=C(C4=C(NC56CC7CC(CC(C7)C5)C6)N5C=CC=CC5=N4)C=C3C2=O)C(=O)N1 Degrader C30H29N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-E9U5CH WO2025129172A1_38 . CC1=CC=C/C2=N/C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)=C(/NC3=CC4=C(C=C3)OCCO4)N12 Degrader C29H25N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-QSKL4U WO2025129172A1_39 . CC1=CN2/C(=N\C(C3=C\C4=C(/C=C\3)C(=O)N(C3CCC(=O)NC3=O)C4)=C/2NC2=CC3=C(C=C2)OCCO3)C=C1 Degrader C29H25N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-BU5AM5 1447701-63-4 2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbaldehyde; 892-811-9; 2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carbaldehyde; 2-(2,6-DIOXO-3-PIPERIDYL)-1,3-DIOXOISOINDOLINE-5-CARBALDEHYDE; SCHEMBL22358875; MFCD34549483; BP-40597; SY419320; DB-407985; CS-0528506; H35985; EN300-37109492; Z5347185710; 2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindole-5-carbaldehyde; 2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxaldehyde O=CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Degrader C14H10N2O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-L1V5DV SCHEMBL31623133 (3S)-3-[6-[(3S)-1-[[2-[(7R)-2-methyl-5-oxa-2-azaspiro[3.4]octan-7-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CN1CC2(C[C@H](C3=NC4=C/C=C(CN5CC[C@H](OC6=CC7=C(C=C6)C(=O)N([C@H]6CCC(=O)NC6=O)C7)C5)\C=C\4C=C3)CO2)C1 Degrader C34H37N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-FMYXWD SCHEMBL31623203 (3S)-3-[6-[(3S,4S)-1-[[2-[(3aR,6aR)-2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl]-8-fluoroquinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione [H][C@]12CCO[C@@]1([H])CN(C1=NC3=C(F)/C=C(CN4C[C@@H](COC)[C@H](OC5=CC6=C(C=C5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)\C=C\3C=N1)C2 Degrader C34H37FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-R9TON7 SCHEMBL31623291 (3S)-3-[6-[(3S,4S)-1-[(8-fluoro-2-methyl-3-morpholin-4-ylquinolin-6-yl)methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C)\C(N4CCOCC4)=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H38FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-F45OW5 SCHEMBL31623309 (3S)-3-[6-[(3S,4S)-1-[(8-fluoro-3-morpholin-4-ylquinolin-7-yl)methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/C=C(N4CCOCC4)\C=N/C3=C2F)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-H7SEI9 SCHEMBL31623281 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[(3-morpholin-4-ylquinolin-7-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/C=C(N4CCOCC4)\C=N/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-U935PN SCHEMBL31623177 (3S)-3-[6-[(3S,4S)-1-[(5-fluoro-3-morpholin-4-ylquinolin-7-yl)methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/C=C(N4CCOCC4)\C=N/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-52G0AS SCHEMBL31623175 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[2-[4-(oxetan-3-yl)piperazin-1-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C(N4CCN(C5COC5)CC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H42N6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-2RDVSR SCHEMBL31623242 (3S)-3-[6-[(3S,4S)-1-[(8-fluoro-2-morpholin-4-ylquinolin-7-yl)methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/C=C\C(N4CCOCC4)=N/C3=C2F)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-4NZ0F6 SCHEMBL31623293 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(morpholine-4-carbonyl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C(=O)N4CCOCC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H36FN5O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-K1D495 SCHEMBL31623317 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(2-hydroxy-2-methylpropyl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(CC(C)(C)O)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C32H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-F9CZS1 SCHEMBL31623134 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[(2-morpholin-4-ylquinolin-7-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/C=C\C(N4CCOCC4)=N/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-O3MDOK SCHEMBL31623226 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-3-(oxan-4-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C\C(C4CCOCC4)=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H37FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-RC4X8R WO2025137053A1_11 . O=C1CC[C@H](N2C(=O)C3=C(C=C(O[C@H]4CCN(CC5=C/C(F)=C6/N=C(C7CCOCC7)C=C/C6=C\5)C4)C=C3)C2=O)C(=O)N1 Degrader C32H31FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-6TLI6A SCHEMBL31623229 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCC(C(C)(C)O)CC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H44FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-B41YJ7 SCHEMBL31623239 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[4-(2-hydroxypropan-2-yl)cyclohexyl]quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL31645365 COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCC(C(C)(C)O)CC4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H44FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-711PT4 SCHEMBL31623205 (3S)-3-[6-[(3S,4S)-1-[[7-[4-(2-hydroxypropan-2-yl)cyclohexyl]isoquinolin-3-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=NC=C3/C=C(C4CCC(C(C)(C)O)CC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C38H46N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-K4N2W9 SCHEMBL31623146 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[2-[4-(1-methylazetidin-3-yl)piperazin-1-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C(N4CCN(C5CN(C)C5)CC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H45N7O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-XZL05Q SCHEMBL31623170 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[2-[1-(oxetan-3-yl)piperidin-4-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C(C4CCN(C5COC5)CC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H43N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-M02KOL SCHEMBL31623209 3-[[(3S,4S)-3-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-5-yl]oxy]-4-(methoxymethyl)pyrrolidin-1-yl]methyl]-N,N-dimethylisoquinoline-7-carboxamide COC[C@@H]1CN(CC2=NC=C3/C=C(C(=O)N(C)C)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C32H35N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-1XZRUE WO2025137053A1_116 . O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@@H]4CN(CC5=CC(F)=C6/N=C(C7CCOCC7)\C=C/C6=C5)C[C@H]4C4=CC=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C38H37FN4O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-X8ANQB SCHEMBL31623298 6-[[(3S,4S)-3-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-5-yl]oxy]-4-(methoxymethyl)pyrrolidin-1-yl]methyl]-8-fluoro-N-methyl-N-(oxan-4-yl)quinoline-2-carboxamide COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C(=O)N(C)C4CCOCC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H40FN5O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-RQWTMA SCHEMBL31623201 (3S)-3-[6-[(3S,4R)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]-4-pyridin-4-ylpyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL31623202 O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@@H]4CN(CC5=CC(F)=C6/N=C(C7CCOCC7)\C=C/C6=C5)C[C@H]4C4=CC=NC=C4)=C/3)C2=O)C(=O)N1 Degrader C37H36FN5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-8Q8TTT SCHEMBL31623160 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[4-(2-hydroxypropan-2-yl)-1-bicyclo[2.2.2]octanyl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C45CCC(C(C)(C)O)(CC4)CC5)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C40H47FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-9KSJOO WO2025137053A1_12 . O=C1CC[C@H](N2C(=O)C3=C(C=C(O[C@H]4CCN(CC5=C/C=C6/N=C(N7CCOCC7)N=C/C6=C\5)C4)C=C3)C2=O)C(=O)N1 Degrader C30H30N6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-L4QZWQ SCHEMBL31623257 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[1-(2-hydroxy-2-methylpropyl)azetidin-3-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CN(CC(C)(C)O)C4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H42FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-BN5ID1 WO2025137053A1_121 . COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCN(C5CN(C)C5)CC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C38H45FN6O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-WWDGBC SCHEMBL31623250 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[2-[1-(1-methylazetidin-3-yl)piperidin-4-yl]quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C(C4CCN(C5CN(C)C5)CC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C38H46N6O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-LL1289 WO2025137053A1_123 . O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@@H]4CN(CC5=CC(F)=C6/N=C(C7CCOCC7)\C=C/C6=C5)C[C@H]4C4CCCC4)=C/3)C2=O)C(=O)N1 Degrader C37H41FN4O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-SAIAH5 SCHEMBL31623303 (3S)-3-[6-[(3S,4S)-1-[[7-(4-acetylpiperazin-1-yl)-1-fluoroisoquinolin-3-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=NC(F)=C3/C=C(N4CCN(C(C)=O)CC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H39FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-9V6FZH SCHEMBL31623195 (3S)-3-[6-[(3R,4R)-4-(cyclopropylmethoxy)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@@H]4CN(CC5=CC(F)=C6/N=C(C7CCOCC7)\C=C/C6=C5)C[C@H]4OCC4CC4)=C/3)C2=O)C(=O)N1 Degrader C36H39FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-ND0WIQ SCHEMBL31623211 (3S)-3-[6-[(3S,4R)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]-4-(2-methylpyridin-4-yl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=NC=CC([C@@H]2CN(CC3=CC(F)=C4/N=C(C5CCOCC5)\C=C/C4=C3)C[C@H]2OC2=C/C3=C(\C=C/2)C(=O)N([C@H]2CCC(=O)NC2=O)C3)=C1 Degrader C38H38FN5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-93Q8WO WO2025137053A1_127 . CC1=CC([C@@H]2CN(CC3=CC(F)=C4/N=C(C5CCOCC5)\C=C/C4=C3)C[C@H]2OC2=C/C3=C(\C=C/2)C(=O)N([C@H]2CCC(=O)NC2=O)C3)=CC(C)=N1 Degrader C39H40FN5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-ACJ036 SCHEMBL31623230 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[6-(oxan-4-yl)-1,5-naphthyridin-2-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C(C4CCOCC4)\C=C/C3=N2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-P8KLIE SCHEMBL31623306 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[7-(oxan-4-yl)-1,8-naphthyridin-3-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CN=C3/N=C(C4CCOCC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-BJQZNS SCHEMBL31623194 (3S)-3-[6-[(3S,4S)-1-[[2-[(3aS,6aS)-2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl]-8-fluoroquinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione [H][C@@]12CCO[C@]1([H])CN(C1=NC3=C(F)/C=C(CN4C[C@@H](COC)[C@H](OC5=CC6=C(C=C5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)\C=C\3C=N1)C2 Degrader C34H37FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-0850V7 SCHEMBL31623185 (3S)-3-[6-[(3S,4R)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]-4-(2-methylpropyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC(C)C[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCOCC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H41FN4O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-82LBST WO2025137053A1_131 . CC(C)(C)C[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCOCC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H43FN4O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-5Q5UU5 SCHEMBL31623186 (3S)-3-[6-[(3R,4R)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]-4-propan-2-yloxypyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC(C)O[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCOCC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H39FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-8DLULO WO2025137053A1_133 . O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@@H]4CN(CC5=CC(F)=C6/N=C(C7CCOCC7)\C=C/C6=C5)C[C@H]4OC4COC4)=C/3)C2=O)C(=O)N1 Degrader C35H37FN4O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-IZ0AWL SCHEMBL31623154 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[2-(oxan-4-yl)pyrido[2,3-d]pyrimidin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CN=C3/N=C(C4CCOCC4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C32H36N6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-2SFQA1 SCHEMBL31623332 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[2-(oxan-4-yl)-1,7-naphthyridin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=N/C=C3/N=C(C4CCOCC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-USADBW SCHEMBL31623210 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[2-(oxan-4-yl)quinoxalin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C=C3/N=C(C4CCOCC4)C=N/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-RRP67V WO2025137053A1_137 . CC(C)(O)[C@@H]1CN(CC2=C/C=C3/N=C(C4CCOCC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H40N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-614UDB WO2025137053A1_138 . COC(C)(C)[C@@H]1CN(CC2=C/C=C3/N=C(C4CCOCC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H42N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-EN3MN1 SCHEMBL31623322 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]-4-(hydroxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@@H]4CN(CC5=C/C(F)=C6/N=C(C7CCOCC7)C=C/C6=C\5)C[C@H]4CO)=C/3)C2=O)C(=O)N1 Degrader C33H35FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-YHCB4I WO2025137053A1_14 . [H][C@]12CCO[C@@]1([H])CN(C1=NC3=C(F)/C=C(CN4C[C@@H](OC5=CC6=C(C=C5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C(F)(F)C4)\C=C\3C=N1)C2 Degrader C32H31F3N6O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-R98EM7 WO2025137053A1_140 . O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@@H]4CN(CC5=C/C(F)=C6/N=C(N7CCOCC7)C=C/C6=C\5)C[C@H]4COC(F)(F)F)=C/3)C2=O)C(=O)N1 Degrader C33H33F4N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-Z7UVBO SCHEMBL31623254 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[4-(oxetan-3-yl)piperazin-1-yl]quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(N4CCN(C5COC5)CC4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H40FN7O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-YXBZC5 SCHEMBL31623289 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[4-(oxetan-3-yl)piperazin-1-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(N4CCN(C5COC5)CC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H41FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-QEREW6 SCHEMBL31623260 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[1-(oxetan-3-yl)piperidin-4-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CCN(C5COC5)CC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H42FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-EGM3GZ SCHEMBL31623238 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CCN(C5COC5)CC4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H41FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-JGSUPV SCHEMBL31623276 (3S)-3-[6-[(3R,4S)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]-4-phenylpyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@H]4CN(CC5=C/C(F)=C6/N=C(C7CCOCC7)C=C/C6=C\5)C[C@@H]4C4=CC=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C38H37FN4O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-12S75X SCHEMBL31623183 (3S)-3-[6-[(3R,4S)-4-cyclopentyl-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@H]4CN(CC5=C/C(F)=C6/N=C(C7CCOCC7)C=C/C6=C\5)C[C@@H]4C4CCCC4)=C/3)C2=O)C(=O)N1 Degrader C37H41FN4O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-PFOF24 WO2025137053A1_147 . CC1=CC([C@H]2CN(CC3=C/C(F)=C4/N=C(C5CCOCC5)C=C/C4=C\3)C[C@@H]2OC2=C/C3=C(\C=C/2)C(=O)N([C@H]2CCC(=O)NC2=O)C3)=CC(C)=N1 Degrader C39H40FN5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-RCK5YP WO2025137053A1_148 . CC(C)C[C@H]1CN(CC2=C/C(F)=C3/N=C(C4CCOCC4)C=C/C3=C\2)C[C@@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H41FN4O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-5QTLOL WO2025137053A1_149 . O=C1CC[C@H](N2CC3=C(/C=C\C(O[C@H]4CN(CC5=C/C(F)=C6/N=C(C7CCOCC7)C=C/C6=C\5)C[C@@H]4C4=CC=NC=C4)=C/3)C2=O)C(=O)N1 Degrader C37H36FN5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-OYQZKN SCHEMBL31623300 (3S)-3-[6-[(3R)-1-[[2-[(3aS,6aS)-2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl]-8-fluoroquinolin-6-yl]methyl]-4,4-difluoropyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione [H][C@@]12CCO[C@]1([H])CN(C1=NC3=C(F)C=C(CN4C[C@@H](OC5=C/C6=C(\C=C/5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C(F)(F)C4)C=C3C=C1)C2 Degrader C33H32F3N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-Q5BT5Z SCHEMBL31623165 (3S)-3-[6-[(3R,4S)-4-(2,2-dimethylpropyl)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC(C)(C)C[C@H]1CN(CC2=C/C(F)=C3/N=C(C4CCOCC4)C=C/C3=C\2)C[C@@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H43FN4O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-ELMUK7 WO2025137053A1_151 . CC1=NC=CC([C@H]2CN(CC3=C/C(F)=C4/N=C(C5CCOCC5)C=C/C4=C\3)C[C@@H]2OC2=C/C3=C(\C=C/2)C(=O)N([C@H]2CCC(=O)NC2=O)C3)=C1 Degrader C38H38FN5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-QA80LN WO2025137053A1_152 . O=C1CCC(N2CC3=C(/C=C\C(O[C@H]4CN(CC5=C/C(F)=C6/N=C(C7CCOCC7)C=C/C6=C\5)C[C@@H]4OC4COC4)=C/3)C2=O)C(=O)N1 Degrader C35H37FN4O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-K8TWVD WO2025137053A1_16 . [H][C@@]12CCO[C@]1([H])CN(C1=NC3=CC=C(CN4C[C@@H](COC)[C@H](OC5=C/C6=C(\C=C/5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)C=C3C=C1)C2 Degrader C35H39N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-6JFMDE WO2025137053A1_17 . [H][C@@]12CCO[C@]1([H])CN(C1=NC3=CC=C(CN4C[C@@H](OC5=C/C6=C(\C=C/5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C(F)(F)C4)C=C3C=C1)C2 Degrader C33H33F2N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-FG36HB WO2025137053A1_18 . [H][C@@]12CCO[C@]1([H])CN(C1=NC3=CC=C(CN4C[C@@H](COC)[C@H](OC5=C/C6=C(\C=C/5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)C=C3C=N1)C2 Degrader C34H38N6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-U70EMW SCHEMBL31623263 (3S)-3-[6-[(3S)-1-[[2-[(3aS,6aS)-2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl]-8-fluoroquinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione [H][C@@]12CCO[C@]1([H])CN(C1=NC3=C(F)C=C(CN4CC[C@H](OC5=C/C6=C(\C=C/5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)C=C3C=N1)C2 Degrader C32H33FN6O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-SWPS43 WO2025137053A1_2 . CN1CC2(C[C@@H](C3=NC4=C/C=C(CN5CC[C@H](OC6=CC7=C(C=C6)C(=O)N([C@H]6CCC(=O)NC6=O)C7)C5)\C=C\4C=C3)CO2)C1 Degrader C34H37N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-FML7OH WO2025137053A1_20 . O=C1CC[C@H](N2CC3=C(C=CC(O[C@H]4CCN(CC5=C/C=C6/N=C([C@@H]7CCO[C@@]8(CCOC8)C7)C=C/C6=C\5)C4)=C3)C2=O)C(=O)N1 Degrader C35H38N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-CAOCPJ WO2025137053A1_21 . O=C1CC[C@H](N2CC3=C(C=CC(O[C@H]4CCN(CC5=C/C=C6/N=C([C@@H]7CCO[C@]8(CCOC8)C7)C=C/C6=C\5)C4)=C3)C2=O)C(=O)N1 Degrader C35H38N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-LEGRI0 WO2025137053A1_22 . O=C1CC[C@H](N2CC3=C(C=CC(O[C@H]4CCN(CC5=C/C=C6/N=C([C@H]7CCO[C@@]8(CCOC8)C7)C=C/C6=C\5)C4)=C3)C2=O)C(=O)N1 Degrader C35H38N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-SW3RAO WO2025137053A1_23 . O=C1CC[C@H](N2CC3=C(C=CC(O[C@H]4CCN(CC5=C/C=C6/N=C([C@H]7CCO[C@]8(CCOC8)C7)C=C/C6=C\5)C4)=C3)C2=O)C(=O)N1 Degrader C35H38N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-J1Q5S9 SCHEMBL31623337 (3S)-3-[6-[(3S,4S)-1-[[7-fluoro-1-(oxane-4-carbonyl)indol-5-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3C(=C/2)\C=CN\3C(=O)C2CCOCC2)C[C@H]1OC1=C/C=C2/C(=O)N([C@H]3CCC(=O)NC3=O)C/C2=C\1 Degrader C34H37FN4O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-5LJA64 SCHEMBL31623206 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[1-(oxane-4-carbonyl)indol-5-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C=C3C(=C/2)\C=CN\3C(=O)C2CCOCC2)C[C@H]1OC1=C/C=C2/C(=O)N([C@H]3CCC(=O)NC3=O)C/C2=C\1 Degrader C34H38N4O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-BMRH9K SCHEMBL31623272 2-[(3R)-2,6-dioxopiperidin-3-yl]-5-[(3S)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]pyrrolidin-3-yl]oxyisoindole-1,3-dione O=C1CC[C@@H](N2C(=O)C3=C(C=C(O[C@H]4CCN(CC5=C/C(F)=C6/N=C(C7CCOCC7)C=C/C6=C\5)C4)C=C3)C2=O)C(=O)N1 Degrader C32H31FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-9R3NRH SCHEMBL31623245 2-[(3R)-2,6-dioxopiperidin-3-yl]-5-[(3S)-1-[(2-morpholin-4-ylquinazolin-6-yl)methyl]pyrrolidin-3-yl]oxyisoindole-1,3-dione O=C1CC[C@@H](N2C(=O)C3=C(C=C(O[C@H]4CCN(CC5=C/C=C6/N=C(N7CCOCC7)N=C/C6=C\5)C4)C=C3)C2=O)C(=O)N1 Degrader C30H30N6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-GIDZ4D SCHEMBL31623178 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[(7-morpholin-4-ylisoquinolin-3-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=NC=C3/C=C(N4CCOCC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-NOYNEM SCHEMBL31623140 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[(3-morpholin-4-ylquinolin-6-yl)methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C\C(N4CCOCC4)=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-5SZSVH WO2025137053A1_3 . CN1CC[C@]2(C[C@H](C3=NC4=C/C=C(CN5CC[C@H](OC6=CC7=C(C=C6)C(=O)N([C@H]6CCC(=O)NC6=O)C7)C5)\C=C\4C=C3)CO2)C1 Degrader C35H39N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-YCQSKD WO2024109918-A1_29-1 . O=C1CCC(N2Cc3nc([C@H]4C[C@@H](C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)sc3C2=O)C(=O)N1 Degrader C22H18F4N4O5S GSPT1 P15170 CRBN WO-2024109918-A1 TPD-ZA9MQ2 WO2024109918-A1_31 . O=C1CCC(N2Cc3cc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)oc3C2=O)C(=O)N1 Degrader C22H18F4N4O6 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-EMU4A5 WO2024109918-A1_33 . O=C1CCC(N2Cc3nc(N4CCN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)CC4)ccc3C2=O)C(=O)N1 Degrader C24H22F4N6O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-JVVO7W WO2024109918-A1_35 . O=C1CCC(N2CC3=C(CC(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)O3)C2=O)C(=O)N1 Degrader C22H20F4N4O6 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-0JF90O WO2024109918-A1_6 . O=C1CCC(N2Cc3cc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)ccc3C2=O)C(=O)N1 Degrader C24H20F4N4O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-RHZQLA WO2024109918-A1_9 . O=C1CCC(N2Cc3nc(C4CN(C(=O)Nc5cc(OC(F)(F)F)ccc5F)C4)ccc3C2=O)C(=O)N1 Degrader C23H19F4N5O5 GSPT1 P15170 CRBN WO-2024109918-A1 TPD-XP9OE9 WO2024125437-A1_25 . CC1(C#Cc2cc(NC(=O)OCc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)ccc2Cl)CC1 Degrader C27H24ClN3O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-QGD7C0 WO2024125437-A1_3 . CC(C)(O)C#Cc1cc(NC(=O)OCc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)ccc1Cl Degrader C26H24ClN3O6 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-EVEG1M WO2024125437-A1_31 . CC1=NC2=C(CCC(NC(=O)OCc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)=C2F)C12CCCC2 Degrader C28H29FN4O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-DWYBZD WO2024125437-A1_4 . Cc1ncc(NC(=O)OCc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cc1C#CC1CC1 Degrader C26H24N4O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-PIY4DN WO2024125437-A1_5 . O=C1CCC(N2Cc3ccc(COC(=O)Nc4cc(C#CC5CC5)c(Cl)cc4F)cc3C2=O)C(=O)N1 Degrader C26H21ClFN3O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-BV1XGN WO2024125437-A1_6 . O=C1CCC(N2Cc3ccc(COC(=O)Nc4ccc(Cl)c(C#CC5(F)COC5)c4)cc3C2=O)C(=O)N1 Degrader C26H21ClFN3O6 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-PK5TI4 WO2024125437-A1_7 . Cc1ncc(NC(=O)OCc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cc1C#Cc1cnn(C)c1 Degrader C27H24N6O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-CLVQJB WO2024125437-A1_8 . CN1C=C(C#Cc2cc(NC(=O)OCc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)ccc2F)CN1 Degrader C27H24FN5O5 GSPT1 P15170 CRBN WO-2024125437-A1 TPD-4806AE WO2024125437-A1_9 . O=C1CCC(N2Cc3ccc(COC(=O)Nc4cc(Sc5cccnc5C(F)(F)F)ccc4F)cc3C2=O)C(=O)N1 Degrader C27H20F4N4O5S GSPT1 P15170 CRBN WO-2024125437-A1 TPD-MZ15CR WO2024125551-A1_52 . NCc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H](C(N)=O)C4CCCC4)n3)ccc12 Degrader C25H27F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-YAO9KF WO2024125551-A1_53 . NCc1ccnc2c1[nH]c1cc(CNc3ncc(CF)c(N[C@H](CC4CC4)C(N)=O)n3)ccc12 Degrader C24H27FN8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-IY59BI WO2024125551-A1_54 . CCC[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CN)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C23H25F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-F9IXT3 WO2024125551-A1_55 . CC(C)(C)[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CN)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C24H27F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-KWKLMR WO2024125551-A1_56 . NCc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H](C(N)=O)C4CCC4)n3)ccc12 Degrader C24H25F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-P8NIZQ WO2024125551-A1_57 . CO[C@@H](C)[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CN)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C23H25F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-XHF3LW WO2024125551-A1_58 . CC(C)(O)[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CN)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C23H25F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-9906JT WO2024125551-A1_6 . Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)ccc12 Degrader C21H18F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-BAYLQY WO2024125551-A1_60 . C[C@@H](O)[C@@H](C)Nc1nc(NCc2ccc3c(c2)nn2c(CO)ccnc32)ncc1C(F)(F)F Degrader C21H22F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-DWH235 WO2024125551-A1_62 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)nn2c(CN)ccnc32)ncc1C(F)(F)F)C(N)=O Degrader C21H22F3N9O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-OWVDD8 WO2024125551-A1_63 . C[C@@H](O)[C@@H](C)Nc1nc(NCc2ccc3c(c2)nn2c(CN)ccnc32)ncc1C(F)(F)F Degrader C21H23F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-KLFZ1E WO2024125551-A1_67 . CO[C@@H](C)[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(C#N)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C23H21F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-JCJFBP WO2024125551-A1_68 . Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@H](C)[C@@H](C)O)n3)ccc12 Degrader C22H23F3N6O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-20YMCO WO2024125551-A1_7 . OCc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(OC4COC4)n3)ccc12 Degrader C21H18F3N5O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-YNJ821 WO2024125551-A1_70 . CC[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(C)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C22H22F3N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-LRC8SY WO2024125551-A1_71 . C[C@H](O)[C@H](C#N)Nc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C(F)(F)F Degrader C22H20F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-MBZST2 WO2024125551-A1_73 . C[C@@H](O)[C@@H](CO)Nc1nc(NCc2ccc3c(c2)[nH]c2c(C#N)ccnc23)ncc1C(F)(F)F Degrader C22H20F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-B6Z6F3 WO2024125551-A1_74 . CO[C@@H](C)[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C#N)C(N)=O Degrader C23H24N8O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-7ROZQ4 WO2024125551-A1_75 . OCc1ccnc2c1NCc1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CNCC[C@@H]4O)n3)ccc1-2 Degrader C24H26F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-QZ4WF9 WO2024125551-A1_77 . OCc1ccnc2c1[nH]c1cc(CNc3ncc(CF)c(N[C@@H]4CCNC[C@@H]4O)n3)ccc12 Degrader C23H26FN7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-4G8EYD WO2024125551-A1_78 . OCc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CNC[C@@H]4O)n3)ccc12 Degrader C22H22F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-JO8DSE WO2024125551-A1_79 . CO[C@@H](C)[C@@H](Nc1nc(NCc2ccc3c(c2)nn2c(CO)ccnc32)ncc1C(F)(F)F)C(N)=O Degrader C22H23F3N8O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-ZEFQ85 WO2024125551-A1_8 . Cc1ccc2[nH]c3cc(CNc4ncc(C(F)(F)F)c(OC5COC5)n4)ccc3c2n1 Degrader C21H18F3N5O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-2X2B5T WO2024125551-A1_80 . OCc1ccnc2c3ccc(CNc4ncc(C(F)(F)F)c(N[C@@H]5CNCC[C@@H]5O)n4)cc3nn12 Degrader C22H23F3N8O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-03AUEX WO2024125551-A1_81 . N#Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CNCC[C@@H]4O)n3)ccc12 Degrader C23H21F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-PVFOJN WO2024125551-A1_82 . CO[C@@H](C)[C@@H](Nc1nc(NCc2ccc3c(c2)[nH]c2c(CO)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C23H24F3N7O3 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-NPFC0O WO2024125551-A1_83 . Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CNCC[C@@H]4O)n3)ccc12 Degrader C23H24F3N7O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-8L704I WO2024125551-A1_84 . CC[C@@H](Oc1nc(NCc2ccc3c(c2)[nH]c2c(CN)ccnc23)ncc1C(F)(F)F)C(N)=O Degrader C22H22F3N7O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-6CK6N2 WO2024125551-A1_85 . N#Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CNCC[C@H]4O)n3)ccc12 Degrader C23H21F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-SW9JFK WO2024125551-A1_86 . N#Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CNC[C@@H]4O)n3)ccc12 Degrader C22H19F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-3YHMMM WO2024125551-A1_87 . N#Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CN(C(=O)CN)CC[C@@H]4O)n3)ccc12 Degrader C25H24F3N9O2 CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-09NRO5 WO2024125551-A1_88 . CN1CC[C@H](O)[C@H](Nc2nc(NCc3ccc4c(c3)[nH]c3c(C#N)ccnc34)ncc2C(F)(F)F)C1 Degrader C24H23F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-J3ADNO WO2024125551-A1_89 . N#Cc1ccnc2c1[nH]c1cc(CNc3ncc(C(F)(F)F)c(N[C@@H]4CCNC[C@@H]4O)n3)ccc12 Degrader C23H21F3N8O CDK12;KIAA1791;CCNK Q9NYV4/Q14004/O75909 DDB1 WO-2024125551-A1 TPD-5E0XSP WO2024193641-A1_5 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(C(=O)c7ccnc(-n8ccnc8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C36H32N8O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-OUPWQH WO2024193641-A1_6 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCC(NC(=O)c7cccc(-n8ccnc8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C38H35N7O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-0YTR48 WO2024193641-A1_7 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCC(NC(=O)c7ccnc(-n8ccnc8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C37H34N8O4 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-EQNWIV WO2024193641-A1_8 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCN(CC7CCN(c8cccc(-n9ccnc9)n8)CC7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C42H44N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-9U31Q3 WO2024193641-A1_9 . O=C1CCC(N2C(=O)c3cccc4c(Cc5ccc(CN6CCC(Nc7ccnc(-n8ccnc8)n7)CC6)cc5)ccc2c34)C(=O)N1 Degrader C36H34N8O3 IKZF1;IKZF3 Q13422/Q9UKT9 CRBN WO-2024193641-A1 TPD-8MULYI SCHEMBL27091017 N-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methyl]-2,2-difluoro-2-[3-(4-quinoxalin-2-ylpyrazol-1-yl)phenyl]acetamide; SCHEMBL29591033 O=C1CCC(N2C(=O)C3=CC=C(CNC(=O)C(F)(F)C4=CC(N5C=C(C6=NC7=C\C=C/C=C\7N=C6)C=N5)=CC=C4)C=C3C2=O)C(=O)N1 Degrader C33H23F2N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BWQ25F SCHEMBL27090587 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(4-methoxypyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27135876 COC1=CC(C2=CN([C@H]3C[C@H](CCCNC4=CC5=C(C=C4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)N=C2)=NC=C1 Degrader C29H30N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YGCZ3V SCHEMBL24289471 N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-[2-oxo-2-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]ethoxy]acetamide O=C1CCC(N2C(=O)C3=CC=C(NC(=O)COCC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C33H30N8O7 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-EUQDOZ SCHEMBL27091294 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]propylamino]isoindole-1,3-dione; SCHEMBL30875247 O=C1CCC(N2C(=O)C3=C\C(NCCCN4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)=C/C=C\3C2=O)C(=O)N1 Degrader C32H32N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-TSU77L SCHEMBL24290332 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidin-1-yl]propylamino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C\C(NCCCN4CCC(N5CCN(C6=NC=CC=C6)CC5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H35N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-T5QYNN SCHEMBL27091018 N-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methyl]-2-[3-(4-pyridin-2-ylpiperazin-1-yl)azetidin-1-yl]acetamide; SCHEMBL29589573 O=C(CN1CC(N2CCN(C3=NC=CC=C3)CC2)C1)NCC1=C/C=C2/C(=O)N(C3CCC(=O)NC3=O)C(=O)/C2=C\1 Degrader C28H31N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PC1DJP SCHEMBL24290360 N-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methyl]-2-[3-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]acetamide; SCHEMBL29590013 O=C(CN1CCCC(N2C=C(C3=NC4=CC=CC=C4N=C3)C=N2)C1)NCC1=C/C2=C(\C=C/1)C(=O)N(C1CCC(=O)NC1=O)C2=O Degrader C32H30N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-1Z9YVZ SCHEMBL27090886 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]propylamino]isoindole-1,3-dione; SCHEMBL29590077 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCN4CCCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H32N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BPGPPK SCHEMBL24290362 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-(4-fluoro-4-phenylpiperidin-1-yl)-6-oxohexyl]amino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(NCCCCCC(=O)N4CCC(F)(C5=CC=CC=C5)CC4)C=C3C2=O)C(=O)N1 Degrader C30H33FN4O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JIPGDU SCHEMBL24289648 1-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methyl]-3-[3-(4-quinoxalin-2-ylpyrazol-1-yl)cyclohexyl]urea; SCHEMBL29590386 O=C1CCC(N2C(=O)C3=C(/C=C(CNC(=O)NC4CCCC(N5C=C(C6=CN=C7C=CC=CC7=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H30N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HRX4LQ SCHEMBL27090924 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-pyridin-2-ylpiperazin-1-yl)piperidin-1-yl]propylamino]isoindole-1,3-dione; SCHEMBL30875268 O=C1CCC(N2C(=O)C3=CC=C(NCCCN4CCCC(N5CCN(C6=NC=CC=C6)CC5)C4)C=C3C2=O)C(=O)N1 Degrader C30H37N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-SUYSV1 SCHEMBL27090873 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]anilino]ethylamino]isoindole-1,3-dione; SCHEMBL30875381 O=C1CCC(N2C(=O)C3=C(C=C(NCCNC4=CC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=CC=C4)C=C3)C2=O)C(=O)N1 Degrader C37H35N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-6N79GG SCHEMBL27090757 2-(2,6-Dioxopiperidin-3-yl)-5-[7-(4-quinoxalin-2-ylpyrazol-1-yl)heptyl]isoindole-1,3-dione; SCHEMBL29589709 O=C1CCC(N2C(=O)C3=C(C=C(CCCCCCCN4C=C(C5=CN=C6C=CC=CC6=N5)C=N4)C=C3)C2=O)C(=O)N1 Degrader C31H30N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YR8YVA SCHEMBL27090991 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[3-(4-quinoxalin-2-ylpyrazol-1-yl)anilino]ethylamino]isoindole-1,3-dione; SCHEMBL30875332 O=C1CCC(N2C(=O)C3=CC=C(NCCNC4=CC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)=CC=C4)C=C3C2=O)C(=O)N1 Degrader C32H26N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-97Q67F SCHEMBL27091285 2-(2,6-Dioxopiperidin-3-yl)-5-[6-(4-quinoxalin-2-ylpyrazol-1-yl)hexoxy]isoindole-1,3-dione; SCHEMBL29589901 O=C1CCC(N2C(=O)C3=CC=C(OCCCCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)C=C3C2=O)C(=O)N1 Degrader C30H28N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-1OV8QZ SCHEMBL24290180 2-(2,6-Dioxopiperidin-3-yl)-5-[3-(4-quinoxalin-2-ylpyrazol-1-yl)propylamino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C\C(NCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)=C/C=C\3C2=O)C(=O)N1 Degrader C27H23N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-SKC5VA SCHEMBL24290200 2-(2,6-Dioxopiperidin-3-yl)-5-[5-(4-quinoxalin-2-ylpyrazol-1-yl)pentylamino]isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C\C(NCCCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H27N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-WEEL4V SCHEMBL27091147 5-[2-[3-[4-(8-Bromoquinoxalin-2-yl)pyrazol-1-yl]anilino]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875567 O=C1CCC(N2C(=O)C3=CC=C(NCCNC4=CC(N5C=C(C6=N/C7=C(Br)C=CC=C7/N=C\6)C=N5)=CC=C4)C=C3C2=O)C(=O)N1 Degrader C32H25BrN8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-MFTHZI SCHEMBL27091107 2-(2,6-Dioxopiperidin-3-yl)-5-[1-[3-(4-quinoxalin-2-ylpyrazol-1-yl)propyl]piperidin-4-yl]isoindole-1,3-dione; SCHEMBL29589630 O=C1CCC(N2C(=O)C3=C(/C=C(C4CCN(CCCN5C=C(C6=C\N=C7\C=CC=C\C7=N\6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HAN9JK SCHEMBL24290194 N-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]methyl]-2-[3-(4-pyridin-2-ylpiperazin-1-yl)piperidin-1-yl]acetamide O=C(CN1CCCC(N2CCN(C3=NC=CC=C3)CC2)C1)NCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Degrader C30H35N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LG6UWZ SCHEMBL24290185 2-(2,6-Dioxopiperidin-3-yl)-5-[4-(4-quinoxalin-2-ylpyrazol-1-yl)butylamino]isoindole-1,3-dione; SCHEMBL29591750 O=C1CCC(N2C(=O)C3=C(C=C(NCCCCN4C=C(C5=C\N=C6\C=CC=C\C6=N\5)C=N4)C=C3)C2=O)C(=O)N1 Degrader C28H25N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BNCXZ7 SCHEMBL27090574 3-[3-oxo-6-[6-(4-quinoxalin-2-ylpyrazol-1-yl)hexylamino]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL29589626 O=C1CCC(N2CC3=C(/C=C\C(NCCCCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)=C/3)C2=O)C(=O)N1 Degrader C30H31N7O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-UA8UTG SCHEMBL24290201 5-[2-[3-[4-[4-(8-Bromoquinoxalin-2-yl)pyrazol-1-yl]piperidin-1-yl]anilino]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875298 O=C1CCC(N2C(=O)C3=C(/C=C(NCCNC4=CC(N5CCC(N6C=C(C7=N/C8=C(Br)C=CC=C8/N=C\7)C=N6)CC5)=CC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C37H34BrN9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-3ZLYF9 SCHEMBL24290186 2-(2,6-Dioxopiperidin-3-yl)-5-[4-[3-(4-quinoxalin-2-ylpyrazol-1-yl)propyl]piperidin-1-yl]isoindole-1,3-dione; SCHEMBL29589575 O=C1CCC(N2C(=O)C3=C(C=C(N4CCC(CCCN5C=C(C6=C\N=C7\C=CC=C\C7=N\6)C=N5)CC4)C=C3)C2=O)C(=O)N1 Degrader C32H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KVX6WQ SCHEMBL24290187 2-(2,6-Dioxopiperidin-3-yl)-5-[1-[4-(4-quinoxalin-2-ylpyrazol-1-yl)butyl]azetidin-3-yl]isoindole-1,3-dione; SCHEMBL29590049 O=C1CCC(N2C(=O)C3=C(/C=C(C4CN(CCCCN5C=C(C6=CN=C7C=CC=CC7=N6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-TPFRJ3 SCHEMBL24289522 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-quinoxalin-2-ylpyrazol-1-yl)phenyl]propylamino]isoindole-1,3-dione; SCHEMBL29589998 O=C1CCC(N2C(=O)C3=C(C=C(NCCCC4=CC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)=CC=C4)C=C3)C2=O)C(=O)N1 Degrader C33H27N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-TYP0YV SCHEMBL27091420 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[3-(4-phenylpiperidin-1-yl)anilino]ethylamino]isoindole-1,3-dione; SCHEMBL30875288 O=C1CCC(N2C(=O)C3=C(C=C(NCCNC4=CC(N5CCC(C6=CC=CC=C6)CC5)=CC=C4)C=C3)C2=O)C(=O)N1 Degrader C32H33N5O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-NMWZOG SCHEMBL24290188 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)butyl]azetidin-1-yl]isoindole-1,3-dione; SCHEMBL29589487 O=C1CCC(N2C(=O)C3=C\C(N4CC(CCCCN5C=C(C6=CN=C7C=CC=CC7=N6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YBQ7ZM SCHEMBL27090649 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]phenyl]propylamino]isoindole-1,3-dione; SCHEMBL30875519 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCC4=CC=CC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=C4)\C=C/3)C2=O)C(=O)N1 Degrader C38H36N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KKT1QX SCHEMBL27090999 2-(2,6-Dioxopiperidin-3-yl)-5-[6-(4-quinoxalin-2-ylpyrazol-1-yl)hex-1-ynyl]isoindole-1,3-dione; SCHEMBL29589636 O=C1CCC(N2C(=O)C3=CC=C(C#CCCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)C=C3C2=O)C(=O)N1 Degrader C30H24N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9PTM3U SCHEMBL27090933 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[3-[4-(1,3-thiazol-2-yl)piperidin-1-yl]anilino]ethylamino]isoindole-1,3-dione; SCHEMBL30875272 O=C1CCC(N2C(=O)C3=C(/C=C(NCCNC4=CC(N5CCC(C6=NC=CS6)CC5)=CC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C29H30N6O4S GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JMO65T SCHEMBL27090858 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-quinoxalin-2-ylpyrazol-1-yl)azetidin-1-yl]propylamino]isoindole-1,3-dione; SCHEMBL29589824 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCN4CC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C30H28N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-1X0RKD SCHEMBL27090897 2-(2,6-Dioxopiperidin-3-yl)-5-[2-[3-(4-pyridin-2-ylpiperazin-1-yl)anilino]ethylamino]isoindole-1,3-dione; SCHEMBL30875505 O=C1CCC(N2C(=O)C3=C(/C=C(NCCNC4=CC(N5CCN(C6=NC=CC=C6)CC5)=CC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C30H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-MHN17X WO-2022073469-A1_GS-373 . O=C1CCC(N2C(=O)C3=C\C(NCCNC4CC(N5C=C(C6C=NC7=CC=CC=C7N6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C30H30N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-DFJV68 SCHEMBL27090756 3-[3-oxo-6-[6-(4-quinoxalin-2-ylpyrazol-1-yl)hexyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875456 O=C1CCC(N2CC3=C\C(CCCCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)=C/C=C\3C2=O)C(=O)N1 Degrader C30H30N6O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4YYT7E SCHEMBL27091296 3-[3-oxo-6-[7-(4-quinoxalin-2-ylpyrazol-1-yl)heptyl]-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL30875342 O=C1CCC(N2CC3=CC(CCCCCCCN4C=C(C5=NC6=CC=CC=C6N=C5)C=N4)=CC=C3C2=O)C(=O)N1 Degrader C31H32N6O3 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-3DCFD7 WO-2022073469-A1_GS-376 . O=C1CCC(N2C(=O)C3=C(C=C(NCCCCCCN4C=C(C5=N/C6C(=CC=CC6Cl)/N=C\5)C=N4)C=C3)C2=O)C(=O)N1 Degrader C30H30ClN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-254HA4 SCHEMBL27091065 2-(2,6-Dioxopiperidin-3-yl)-5-[6-[4-(8-fluoroquinoxalin-2-yl)pyrazol-1-yl]hexylamino]isoindole-1,3-dione; SCHEMBL29591559 O=C1CCC(N2C(=O)C3=CC=C(NCCCCCCN4C=C(C5=NC6=C(F)C=CC=C6N=C5)C=N4)C=C3C2=O)C(=O)N1 Degrader C30H28FN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-QT6NKC SCHEMBL24291576 N-[4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]butyl]-4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidine-1-carboxamide O=C1CCC(N2C(=O)C3=CC=C(NCCCCNC(=O)N4CCC(N5C=C(C6=NC7=CC=CC=C7N=C6)C=N5)CC4)C=C3C2=O)C(=O)N1 Degrader C34H35N9O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-DAHNJW SCHEMBL27090870 2-(2,6-Dioxopiperidin-3-yl)-5-[6-(2-methyl-4-quinoxalin-2-ylimidazol-1-yl)hexylamino]isoindole-1,3-dione; SCHEMBL30875348 CC1=NC(C2=NC3=CC=CC=C3N=C2)=CN1CCCCCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Degrader C31H31N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-2S82OT WO-2022073469-A1_GS-381 . O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCCN4C=C(C5=NC6C(=CC=CC6N6CCOCC6)N=C5)C=N4)\C=C/3)C2=O)C(=O)N1 Degrader C34H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-W2L1OK SCHEMBL24291569 2-(2,6-Dioxopiperidin-3-yl)-5-[6-[4-[8-(oxan-4-yl)quinoxalin-2-yl]pyrazol-1-yl]hexylamino]isoindole-1,3-dione; SCHEMBL30875442 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCCN4C=C(C5=NC6=C(C7CCOCC7)C=CC=C6N=C5)C=N4)\C=C/3)C2=O)C(=O)N1 Degrader C35H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-J8WA8I WO-2022073469-A1_GS-383 . CN1CCN(C2C=CC=C3N=CC(C4=CN(CCCCCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)N=C4)=NC32)CC1 Degrader C35H41N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-USYXFJ SCHEMBL27090993 2-(2,6-Dioxopiperidin-3-yl)-5-[6-[4-(8-piperazin-1-ylquinoxalin-2-yl)pyrazol-1-yl]hexylamino]isoindole-1,3-dione; SCHEMBL30616987 O=C1CCC(N2C(=O)C3=CC=C(NCCCCCCN4C=C(C5=N/C6=C(N7CCNCC7)C=CC=C6/N=C\5)C=N4)C=C3C2=O)C(=O)N1 Degrader C34H37N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-62MMYS SCHEMBL27090764 2-(2,6-Dioxopiperidin-3-yl)-5-[6-[(5-quinoxalin-2-yl-1,3-thiazol-2-yl)amino]hexylamino]isoindole-1,3-dione; SCHEMBL30875351 O=C1CCC(N2C(=O)C3=CC=C(NCCCCCCNC4=NC=C(C5=NC6=CC=CC=C6N=C5)S4)C=C3C2=O)C(=O)N1 Degrader C30H29N7O4S GSPT1 P15170 CRBN WO-2022073469-A1 TPD-IHFYNB SCHEMBL27090983 2-(2,6-Dioxopiperidin-3-yl)-5-[6-(5-quinoxalin-2-yl-1,3-thiazol-2-yl)hexylamino]isoindole-1,3-dione; SCHEMBL30875579 O=C1CCC(N2C(=O)C3=C\C(NCCCCCCC4=NC=C(C5=NC6=C/C=C\C=C\6N=C5)S4)=C/C=C\3C2=O)C(=O)N1 Degrader C30H28N6O4S GSPT1 P15170 CRBN WO-2022073469-A1 TPD-RAVDPB SCHEMBL27090902 2-(2,6-Dioxopiperidin-3-yl)-5-[6-[4-(7-methoxyquinoxalin-2-yl)pyrazol-1-yl]hexylamino]isoindole-1,3-dione; SCHEMBL29591778 COC1=CC=C2N=CC(C3=CN(CCCCCCNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C3)=NC2=C1 Degrader C31H31N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LP92YP SCHEMBL27091128 2-(2,6-Dioxopiperidin-3-yl)-5-[6-[4-[8-(1-methylpiperidin-4-yl)quinoxalin-2-yl]pyrazol-1-yl]hexylamino]isoindole-1,3-dione; SCHEMBL30616917 CN1CCC(C2=C3N=C(C4=CN(CCCCCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)N=C4)C=NC3=CC=C2)CC1 Degrader C36H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-8P2M5W SCHEMBL24290786 5-[6-[4-(8-Cyclopropylquinoxalin-2-yl)pyrazol-1-yl]hexylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCCN4C=C(C5=CN=C6C=CC=C(C7CC7)C6=N5)C=N4)\C=C/3)C2=O)C(=O)N1 Degrader C33H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-EV3TM0 SCHEMBL27090595 2-(2,6-Dioxopiperidin-3-yl)-5-[5-[(5-quinoxalin-2-yl-1,3-thiazol-2-yl)amino]pentylamino]isoindole-1,3-dione; SCHEMBL30875591 O=C1CCC(N2C(=O)C3=C\C(NCCCCCNC4=NC=C(C5=NC6=CC=CC=C6N=C5)S4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H27N7O4S GSPT1 P15170 CRBN WO-2022073469-A1 TPD-34KYQW SCHEMBL27090811 2-(2,6-Dioxopiperidin-3-yl)-5-[6-[4-(8-methoxyquinoxalin-2-yl)pyrazol-1-yl]hexylamino]isoindole-1,3-dione; SCHEMBL29590664 COC1=C2N=C(C3=CN(CCCCCCNC4=C/C5=C(\C=C/4)C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C3)C=NC2=CC=C1 Degrader C31H31N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-QPIM20 SCHEMBL27091412 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[4-(8-morpholin-4-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione; SCHEMBL29591433 O=C1CCC(N2C(=O)C3=CC=C(NCC4CC(N5C=C(C6=NC7=C(N8CCOCC8)C=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C33H32N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-7VOCD9 SCHEMBL27090804 2-(2,6-Dioxopiperidin-3-yl)-5-[6-[4-(8-piperidin-4-ylquinoxalin-2-yl)pyrazol-1-yl]hexylamino]isoindole-1,3-dione; SCHEMBL30616892 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCCN4C=C(C5=NC6=C(C7CCNCC7)C=CC=C6N=C5)C=N4)\C=C/3)C2=O)C(=O)N1 Degrader C35H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HWUBLE SCHEMBL27091153 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[4-(8-fluoroquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione; SCHEMBL29589498 O=C1CCC(N2C(=O)C3=C\C(NCC4CC(N5C=C(C6=NC7=C(F)C=CC=C7N=C6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H24FN7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KASHYW WO-2022073469-A1_GS-395 . CN1C[C@H]2C[C@@H]1CN2C1=CC=C2N=CC(C3=CN(C4CC(CCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)N=C3)=NC2=C1 Degrader C37H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-7CBWVK WO-2022073469-A1_GS-396 . O=C1CCC(N2C(=O)C3=C\C(NCCCC4CC(N5C=C(C6=NC7=CC=C(N8CCOCC8)C=C7N=C6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C35H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OKFF82 WO-2022073469-A1_GS-397 . CN1CCN(C2=CC=C3N=C(C4=CN([C@H]5C[C@H](CCCNC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)N=C4)C=NC3=C2)CC1 Degrader C36H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-WMCCXN SCHEMBL27091020 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[4-[8-(4-methylpiperazin-1-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione; SCHEMBL30875329 CN1CCN(C2=C3N=C(C4=CN(C5CC(CNC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)N=C4)C=NC3=CC=C2)CC1 Degrader C34H35N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JQHGJL WO-2022073469-A1_GS-399 . CC1=NN([C@H]2C[C@H](CCCNC3=C/C=C4/C(=O)N(C5CCC(=O)NC5=O)C(=O)/C4=C\3)C2)C=C1C1=NC2=CC(N3CCOCC3)=CC=C2N=C1 Degrader C36H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-FR4KXG SCHEMBL27090670 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-quinoxalin-2-yl-3-(trifluoromethyl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092039 O=C1CCC(N2C(=O)C3=C\C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC=CC=C7N=C6)C(C(F)(F)F)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C32H28F3N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-PP8X6U WO-2022073469-A1_GS-401 . O=C1CCC(N2C(=O)C3=C\C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7CC=C(N8CCNCC8)C=C7N=C6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C35H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-0IOQB0 WO-2022073469-A1_GS-402 . O=C1CCC(N2C(=O)C3=C\C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC=C(N8CCOCC8)C=C7N=C6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C35H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4UOEH3 SCHEMBL27090618 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(5-morpholin-4-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27134157 O=C1CCC(N2C(=O)C3=C\C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC=CC(N8CCOCC8)=C7N=C6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C35H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-SVHSFF SCHEMBL27091217 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[5-(4-methylpiperazin-1-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092004 CN1CCN(C2=C3N=CC(C4=CN([C@H]5C[C@H](CCCNC6=C/C=C7/C(=O)N(C8CCC(=O)NC8=O)C(=O)/C7=C\6)C5)N=C4)=NC3=CC=C2)CC1 Degrader C36H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-YHA4YO SCHEMBL27091051 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(5-piperazin-1-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27140405 O=C1CCC(N2C(=O)C3=C\C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC=CC(N8CCNCC8)=C7N=C6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C35H37N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CCL03L SCHEMBL27091375 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[7-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091415; SCHEMBL27092050; SCHEMBL30875347 O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(N8CC9CCC(C8)O9)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C37H38N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-G06XL5 SCHEMBL27090664 2-(2,6-dioxopiperidin-3-yl)-5-[3-[3-[3-methyl-4-[7-[(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092051 CC1=NN([C@H]2C[C@H](CCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C2)C=C1C1=NC2=CC(N3C[C@H]4C[C@@H]3CN4C)=CC=C2N=C1 Degrader C38H41N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-M23AEW WO-2022073469-A1_GS-408 . C=C1CN(C2=CC=C3N=CC(C4=CN(C5CC(CCCNC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)N=C4)=NC3=C2)C[C@@H](C)N1C Degrader C38H41N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-0QHCFM SCHEMBL27090937 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[7-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092033 CN1C2CCC1CN(C1=CC=C3N=CC(C4=CN([C@H]5C[C@H](CCCNC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)N=C4)=NC3=C1)C2 Degrader C38H41N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-HBKO7K SCHEMBL27090562 2-(2,6-dioxopiperidin-3-yl)-5-[3-[3-[4-[7-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091971 O=C1CCC(N2C(=O)C3=CC=C(NCCCC4CC(N5C=C(C6=NC7=CC(N8C[C@H]9C[C@@H]8CO9)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C36H36N8O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-D3HSBF WO-2022073469-A1_GS-411 . CN1C[C@H]2C[C@@H]1CN2C1=CC=C2N=CC(C3=CN([C@H]4C[C@H](CCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)N=C3)=NC2=C1 Degrader C37H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-F4LNUC WO-2022073469-A1_GS-412 . CN1CCN(C2=CC=C3N=C(C4=CN([C@H]5C[C@@H](CCCNC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)N=C4)C=NC3=C2)CC1 Degrader C36H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CR1WEV SCHEMBL27090951 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[7-(4-methyl-4,7-diazaspiro[2.5]octan-7-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27149791 CN1CCN(C2=CC=C3N=CC(C4=CN([C@H]5C[C@H](CCCNC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)N=C4)=NC3=C2)CC12CC2 Degrader C38H41N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KQLUV9 SCHEMBL27091085 5-[3-[3-[4-[7-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl]quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27092027 O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC(N8C[C@H]9C[C@@H]8CN9)=CC=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C36H37N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-05ZWX9 SCHEMBL27090927 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[4-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione CN1CCN(C2=CC=CC(C3=CN([C@H]4C[C@H](CNC5=C/C=C6/C(=O)N(C7CCC(=O)NC7=O)C(=O)/C6=C\5)C4)N=C3)=N2)CC1 Degrader C31H34N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-8DJ6W7 SCHEMBL27091197 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[3-methyl-4-[5-(4-methylpiperazin-1-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092047 CC1=NN([C@H]2C[C@H](CCCNC3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)C=C1C1=C\N=C2\C(N3CCN(C)CC3)=CC=C\C2=N\1 Degrader C37H41N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-B625BK SCHEMBL27090706 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(6-piperazin-1-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27090724; SCHEMBL27091947 O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC=C(N8CCNCC8)C=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C35H37N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OUKJIH SCHEMBL27090625 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[5-(1-methylpiperidin-4-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092012 CN1CCC(C2=CC=C/C3=N/C(C4=CN([C@H]5C[C@H](CCCNC6=CC7=C(C=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)C5)N=C4)=C/N=C\23)CC1 Degrader C37H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-DUF8XV SCHEMBL27090570 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[5-(oxan-4-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091982 O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@H](N5C=C(C6=NC7=CC=CC(C8CCOCC8)=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C36H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CQH73R SCHEMBL27090787 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[3-methyl-4-[6-(4-methylpiperazin-1-yl)quinoxalin-2-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27136040 CC1=NN([C@H]2C[C@@H](CCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C2)C=C1C1=NC2=CC=C(N3CCN(C)CC3)C=C2N=C1 Degrader C37H41N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-BIKNQS WO-2022073469-A1_GS-429 . O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC=C(C8CCNCC8)C=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C36H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-32EOCM WO-2022073469-A1_GS-430 . O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@@H](N5C=C(C6=NC7=CC=C(C8CCOCC8)C=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C36H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-L1JMRE SCHEMBL27091233 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(5-piperidin-4-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27136759 O=C1CCC(N2C(=O)C3=CC=C(NCCCC4CC(N5C=C(C6=NC7=CC=CC(C8CCNCC8)=C7N=C6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C36H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-MDWUOE WO-2022073469-A1_GS-432 . CN1CCC(C2=CC=C3N=C(C4=CN([C@H]5C[C@@H](CCCNC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)N=C4)C=NC3=C2)CC1 Degrader C37H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-NOT6RZ SCHEMBL27091096 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(oxan-4-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27135863 O=C1CCC(N2C(=O)C3=C\C(NCCC[C@H]4C[C@H](N5C=C(C6CCOCC6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C28H33N5O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-AXLEJ0 SCHEMBL27090823 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[3-methyl-4-(6-piperazin-1-ylquinoxalin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092025 CC1=NN([C@H]2C[C@@H](CCCNC3=C/C=C4/C(=O)N(C5CCC(=O)NC5=O)C(=O)/C4=C\3)C2)C=C1C1=NC2=CC=C(N3CCNCC3)C=C2N=C1 Degrader C36H39N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CVW3RT SCHEMBL27091196 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(1-methylpiperidin-4-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27092040 CN1CCC(C2=CN([C@H]3C[C@H](CCCNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2)CC1 Degrader C29H36N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-I00L7W SCHEMBL27091001 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-[2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091983 CN1CCN(C2=NC(C3=CN([C@H]4C[C@H](CCCNC5=C/C=C6/C(=O)N(C7CCC(=O)NC7=O)C(=O)/C6=C\5)C4)N=C3)=CC=N2)CC1 Degrader C32H37N9O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-Z2KLQX SCHEMBL27091093 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-(4-morpholin-4-ylpyrazol-1-yl)cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL30875390 O=C1CCC(N2C(=O)C3=C\C(NCCCC4CC(N5C=C(N6CCOCC6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C27H32N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-CEA3VR SCHEMBL24290343 5-[[3-(3-Cyclopropyl-4-morpholin-4-ylpyrazol-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=C(C=C(NC[C@H]4C[C@H](N5C=C(N6CCOCC6)C(C6CC6)=N5)C4)C=C3)C2=O)C(=O)N1 Degrader C28H32N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-5ZHWMA SCHEMBL27090881 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[4-(6-methylpyridin-2-yl)-3-(trifluoromethyl)pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione CC1=NC(C2=CN([C@H]3C[C@H](CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C(F)(F)F)=CC=C1 Degrader C28H25F3N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OL88PQ SCHEMBL27090641 5-[[3-[3-Cyclopropyl-4-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091089; SCHEMBL30875575 CN1CCN(C2=NC(C3=CN([C@H]4C[C@H](CNC5=C/C=C6/C(=O)N(C7CCC(=O)NC7=O)C(=O)/C6=C\5)C4)N=C3C3CC3)=CC=C2)CC1 Degrader C34H38N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-XPPPKT SCHEMBL27091156 5-[[3-[3-Cyclopropyl-4-[6-(oxan-4-ylamino)pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091423; SCHEMBL30875281 O=C1CCC(N2C(=O)C3=CC=C(NCC4CC(N5C=C(C6=CC=CC(NC7CCOCC7)=N6)C(C6CC6)=N5)C4)C=C3C2=O)C(=O)N1 Degrader C34H37N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9K6WI9 SCHEMBL24289715 5-[[3-(3-Cyclopropylindazol-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875399 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5N=C(C6CC6)C6=C5/C=C\C=C/6)C4)\C=C/3)C2=O)C(=O)N1 Degrader C28H27N5O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-6ZMGPZ SCHEMBL27091279 5-[3-[3-[4-(5-Chloropyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27092044; SCHEMBL30875497 O=C1CCC(N2C(=O)C3=C\C(NCCC[C@H]4C[C@H](N5C=C(C6=NC=C(Cl)C=C6)C=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C28H27ClN6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-W5RCZ5 SCHEMBL27091503 5-[[3-[3-(Difluoromethyl)-4-(6-methylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875592 CC1=CC=CC(C2=CN([C@H]3C[C@H](CNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C3)N=C2C(F)F)=N1 Degrader C28H26F2N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-6K2OID SCHEMBL27091235 5-[[3-[3-Cyclopropyl-4-[6-[(4-hydroxycyclohexyl)amino]pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875539 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(C6=CC=CC(N[C@H]7CC[C@@H](O)CC7)=N6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C35H39N7O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-94LT5I SCHEMBL27090568 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(5-methylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27091935 CC1=CC=C(C2=CN([C@H]3C[C@H](CCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C3)N=C2)N=C1 Degrader C29H30N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-4DXDAM SCHEMBL27090572 5-[3-[3-[4-(6-Cyclopropylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27091986; SCHEMBL30875444 O=C1CCC(N2C(=O)C3=CC=C(NCCC[C@H]4C[C@H](N5C=C(C6=CC=CC(C7CC7)=N6)C=N5)C4)C=C3C2=O)C(=O)N1 Degrader C31H32N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-JB3YBQ SCHEMBL27091069 5-[[3-(3-Cyclopropyl-4-piperidin-1-ylpyrazol-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875396 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(N6CCCCC6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C29H34N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-J2G2YR SCHEMBL27091039 2-(2,6-Dioxopiperidin-3-yl)-5-[[3-[3-methyl-4-(6-methylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]isoindole-1,3-dione CC1=CC=CC(C2=CN(C3CC(CNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C3)N=C2C)=N1 Degrader C28H28N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LPQLKF SCHEMBL27090564 5-[4-(3-Cyclopropyl-4-quinoxalin-2-ylpyrazol-1-yl)butylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione O=C1CCC(N2C(=O)C3=CC=C(NCCCCN4C=C(C5=N/C6=C(C=CC=C6)/N=C\5)C(C5CC5)=N4)C=C3C2=O)C(=O)N1 Degrader C31H29N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-9KBQKA WO-2022073469-A1_GS-451 . O=C1CCC(N2C(=O)/C3=C/C=C(/NCCCC4CC(N5C=C(C6=CC=CC(N7CCC7)=N6)C=N5)C4)CC3C2=O)C(=O)N1 Degrader C31H35N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-VXA7QZ SCHEMBL27090709 5-[[3-[3-Cyclopropyl-4-(4-hydroxypiperidin-1-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875590 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5C=C(N6CCC(O)CC6)C(C6CC6)=N5)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C29H34N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-8RWEGZ SCHEMBL24290210 2-(2,6-Dioxopiperidin-3-yl)-5-[3-[3-[4-(6-propan-2-ylpyridin-2-yl)pyrazol-1-yl]cyclobutyl]propylamino]isoindole-1,3-dione; SCHEMBL27090918; SCHEMBL27135879 CC(C)C1=CC=CC(C2=CN([C@H]3C[C@H](CCCNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2)=N1 Degrader C31H34N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-TXEPMK SCHEMBL27090602 5-[[3-[3-Cyclopropyl-4-[6-[(1-methylpiperidin-4-yl)amino]pyridin-2-yl]pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875362 CN1CCC(NC2=NC(C3=CN([C@H]4C[C@H](CNC5=C/C=C6/C(=O)N(C7CCC(=O)NC7=O)C(=O)/C6=C\5)C4)N=C3C3CC3)=CC=C2)CC1 Degrader C35H40N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LOJ8C9 SCHEMBL27090722 5-[[3-(3-Cyclopropyl-4-piperazin-1-ylpyrazol-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875249 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(N6CCNCC6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C28H33N7O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-Y9IE4H SCHEMBL27091214 5-[[3-[4-(4-Chlorophenyl)-3-cyclopropylpyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875431 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=CC=C(Cl)C=C6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C30H28ClN5O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-0UYHKY SCHEMBL24290218 5-[[3-[3-Cyclopropyl-4-(6-cyclopropyloxypyridin-2-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875296 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5C=C(C6=CC=CC(OC7CC7)=N6)C(C6CC6)=N5)C4)\C=C/3)C2=O)C(=O)N1 Degrader C32H32N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-GGVVXI SCHEMBL27090714 5-[[3-[3-Cyclopropyl-4-(1-methylpiperidin-3-yl)pyrazol-1-yl]cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875473 CN1CCCC(C2=CN([C@H]3C[C@H](CNC4=C/C=C5/C(=O)N(C6CCC(=O)NC6=O)C(=O)/C5=C\4)C3)N=C2C2CC2)C1 Degrader C30H36N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-LDDV8L SCHEMBL27091139 5-[[3-(3-Cyclopropylpyrazolo[3,4-c]pyridin-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875333 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5N=C(C6CC6)C6=C5/C=N\C=C/6)C4)\C=C/3)C2=O)C(=O)N1 Degrader C27H26N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-V7QPJJ SCHEMBL24290239 5-[[3-(3-Cyclopropylpyrazolo[4,3-c]pyridin-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL30875356 O=C1CCC(N2C(=O)C3=C\C(NC[C@H]4C[C@H](N5N=C(C6CC6)C6=C\N=C/C=C\65)C4)=C/C=C\3C2=O)C(=O)N1 Degrader C27H26N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-KML6XM SCHEMBL24291936 5-[[3-(3-Cyclopropylpyrazolo[4,3-b]pyridin-1-yl)cyclobutyl]methylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; SCHEMBL27090785; SCHEMBL30875562 O=C1CCC(N2C(=O)C3=C(/C=C(NC[C@H]4C[C@H](N5/N=C(/C6CC6)C6=C5C=CC=N6)C4)\C=C/3)C2=O)C(=O)N1 Degrader C27H26N6O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-Z4QA41 SCHEMBL27090691 N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-3-[4-(4-quinoxalin-2-ylpyrazol-1-yl)piperidin-1-yl]benzamide; SCHEMBL29589566 O=C1CCC(N2CC3=C(/C=C\C(CNC(=O)C4=CC(N5CCC(N6C=C(C7=NC8=CC=CC=C8N=C7)C=N6)CC5)=CC=C4)=C/3)C2=O)C(=O)N1 Degrader C37H34N8O4 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-ZTG3VN SCHEMBL24290428 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-quinoxalin-2-ylpiperidin-1-yl)hexyl]amino]isoindole-1,3-dione; SCHEMBL30875482 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(C5=NC6=CC=CC=C6N=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C32H34N6O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-OCU7C6 SCHEMBL24289732 2-(2,6-dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-quinolin-2-yl-3,6-dihydro-2H-pyridin-1-yl)hexyl]amino]isoindole-1,3-dione; SCHEMBL30875394 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CC=C(C5=NC6=CC=CC=C6C=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C33H33N5O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-INNLAO SCHEMBL27090773 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-(4-quinolin-2-ylpiperidin-1-yl)hexyl]amino]isoindole-1,3-dione; SCHEMBL30875500 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(C5=NC6=CC=CC=C6C=C5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C33H35N5O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-SISSOR SCHEMBL27090723 2-(2,6-Dioxopiperidin-3-yl)-5-[[6-oxo-6-[4-[4-[8-(1,2,3,6-tetrahydropyridin-4-yl)quinoxalin-2-yl]pyrazol-1-yl]piperidin-1-yl]hexyl]amino]isoindole-1,3-dione; SCHEMBL30875253 O=C1CCC(N2C(=O)C3=C(/C=C(NCCCCCC(=O)N4CCC(N5C=C(C6=N/C7=C(C8=CCNCC8)C=CC=C7/N=C\6)C=N5)CC4)\C=C/3)C2=O)C(=O)N1 Degrader C40H43N9O5 GSPT1 P15170 CRBN WO-2022073469-A1 TPD-58GBEZ WO2024222614A1_3 . O=C1CCC(N2CC3=CC(CN4C=C(CC5CCOCC5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H25N5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-DUL83T WO2024222614A1_30 . O=C1CCC(N2CC3=CC(CN4C=C(OC5=CC=C(Cl)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H18ClN5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-9TB2IT SCHEMBL31135373 3-[6-[1-(4-benzyltriazol-1-yl)ethyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC(C1=CC=C2C(=O)N(C3CCC(=O)NC3=O)CC2=C1)N1C=C(CC2=CC=CC=C2)N=N1 Degrader C24H23N5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-94BQWZ SCHEMBL31135348 3-[6-[[4-(5-chloro-2-hydroxyphenyl)triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(C5=C(O)C=CC(Cl)=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H18ClN5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-VRJY4X SCHEMBL31135324 3-[6-[[4-(3-chloro-4-fluoroanilino)triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(NC5=CC(Cl)=C(F)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H18ClFN6O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-0ZNQ5U WO2024222614A1_34 . NC1=CC=C(Cl)C=C1C1=CN(CC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)N=N1 Degrader C22H19ClN6O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-HPYIZK SCHEMBL31135356 3-[6-[[4-(5-chloro-2-fluorophenyl)triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(C5=CC(Cl)=CC=C5F)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H17ClFN5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-3OPVMT WO2024222614A1_36 . O=C1CCC(N2CC3=CC(CN4C=C(OC5=C(F)C=CC(OC(F)(F)F)=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H17F4N5O5 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-3AW4QY WO2024222614A1_37 . O=C1CCC(N2CC3=CC(CN4C=C(OC5=CC=C(Cl)C=C5F)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H17ClFN5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-QU3REP WO2024222614A1_38 . O=C1CCC(N2CC3=CC(CN4C=C(OC5=CC(OC(F)(F)F)=C(F)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H17F4N5O5 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-7QO7RB WO2024222614A1_39 . O=C1CCC(N2CC3=C(F)C(CN4C=C(OC5=CC=C(F)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H17F2N5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-S1EVER WO2024222614A1_4 . COC1=CC=C(CC2=CN(CC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)N=N2)C=C1 Degrader C24H23N5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-VGTTF3 WO2024222614A1_40 . O=C1CCC(N2CC3=C(F)C(CN4C=C(OC5=CC=C(Cl)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C22H17ClFN5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-MRW834 SCHEMBL31135333 4-[1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]triazol-4-yl]oxybenzonitrile N#CC1=CC=C(OC2=CN(CC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)N=N2)C=C1 Degrader C23H18N6O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-683VLE SCHEMBL31135337 3-[6-[[4-[2-fluoro-5-(trifluoromethoxy)anilino]triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(NC5=C(F)C=CC(OC(F)(F)F)=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H18F4N6O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-IKCMIN SCHEMBL31135341 3-[6-[[4-(2-hydroxy-5-methylphenyl)triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC=C(O)C(C2=CN(CC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)N=N2)=C1 Degrader C23H21N5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-RGAN6W SCHEMBL31135369 3-[6-[[4-(4-methylphenoxy)triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione CC1=CC=C(OC2=CN(CC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)N=N2)C=C1 Degrader C23H21N5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-O6RNNR WO2024222614A1_5 . O=C1CCC(N2CC3=CC(CN4C=C(C5(C6=CC=CC=C6)CC5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C25H23N5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-D0HYCL WO2024222614A1_6 . O=C1CCC(N2CC3=CC(CN4C=C(CC5=CC=C(F)C=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H20FN5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-4VAV9G SCHEMBL31135359 3-[6-[(4-benzyltriazol-1-yl)methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(CC5=CC=CC=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H21N5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-ZUQSU2 WO2024222614A1_8 . O=C1CCC(N2CC3=CC(CN4C=C(CC5CCCCC5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C23H27N5O3 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-M9TVVV SCHEMBL31135318 3-[6-[[4-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]triazol-1-yl]methyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione O=C1CCC(N2CC3=CC(CN4C=C(CC5=C(F)C=CC(OC(F)(F)F)=C5)N=N4)=CC=C3C2=O)C(=O)N1 Degrader C24H19F4N5O4 GSPT1 P15170 CRBN WO-2024222614-A1 TPD-8BFZNF WO2025026218A1_C052 . O=C1CCC(N2CC3=C(C=C(CC(F)(F)C(=O)NC4=CC(NC5CCC(F)(F)CC5)=CC=C4F)C=C3)C2=O)C(=O)N1 Degrader C28H27F5N4O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-P9CAME WO2025026218A1_C058 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(C5=C(C(F)(F)F)C=NN5)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C25H19F4N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-0SOXT7 WO2025026218A1_C059 . CCN1N=CC(C(F)(F)F)=C1C1=CC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1 Degrader C27H23F4N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-59L0WI WO2025026218A1_C064 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=CC(S(F)(F)(F)(F)F)=CC=C4)\C=C/3)C2=O)C(=O)N1 Degrader C22H20F5N3O4S GSPT1 P15170 CRBN WO-2025026218-A1 TPD-T074GG WO2025026218A1_C065 . O=C1CCC(N2CC3=C(/C=C(CCC(=O)NC4=C(F)C=CC(S(=O)(=O)C(F)(F)F)=C4)\C=C/3)C2=O)C(=O)N1 Degrader C23H19F4N3O6S GSPT1 P15170 CRBN WO-2025026218-A1 TPD-BAANPM WO2025026218A1_C066 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=C(F)C=CC(S(=O)(=O)C(F)(F)F)=C4)\C=C/3)C2=O)C(=O)N1 Degrader C22H17F4N3O7S GSPT1 P15170 CRBN WO-2025026218-A1 TPD-4KPA9L WO2025026218A1_C067 . CC(C)(C)C1=C(NCC(F)(F)F)C=C(NC(=O)CCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C28H31F3N4O4 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-LACECZ WO2025026218A1_C068 . CCN(CC(F)(F)F)C1=NC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1 Degrader C24H23F4N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-5WJ2YM WO2025026218A1_C069 . CN(C1=NC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1)C1CCC(F)(F)CC1 Degrader C27H28F3N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-IYABXH WO2025026218A1_C070 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NCC(F)(F)F)=C(Cl)C=C4)\C=C/3)C2=O)C(=O)N1 Degrader C23H20ClF3N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-2LI73I WO2025026218A1_C071 . N#CC1=C(NC2CCC(F)(F)CC2)C=C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)C=C1 Degrader C28H27F2N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-MV5223 WO2025026218A1_C074 . CN(CC(F)(F)F)C1=NC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1 Degrader C23H21F4N5O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-35RKUA WO2025026218A1_C082 . CN(C1=CC=C(F)C(NC(=O)OCC2=C/C3=C(\C=C/2)CN(C2CCC(=O)NC2=O)C3=O)=C1)S(C)(=O)=O Degrader C23H23FN4O7S GSPT1 P15170 CRBN WO-2025026218-A1 TPD-5MIVTY WO2025026218A1_C084 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NCC(F)(F)F)=C(F)C=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C23H19F5N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-V1PLQM WO2025026218A1_C087 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(SC(F)(F)F)=CC=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C22H17F4N3O5S GSPT1 P15170 CRBN WO-2025026218-A1 TPD-APCGS1 WO2025026218A1_C088 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NCC5=C(F)C=CC=C5)=C(F)C=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C28H23F3N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-ARNZKO WO2025026218A1_C089 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NC5CCC(F)(F)CC5)=C(F)C=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C27H26F4N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-B4T20T WO2025026218A1_C090 . O=C1CCC(N2CC3=C(/C=C(COC(=O)NC4=CC(NCC(F)(F)F)=C(C(F)(F)F)C=C4F)\C=C/3)C2=O)C(=O)N1 Degrader C24H19F7N4O5 GSPT1 P15170 CRBN WO-2025026218-A1 TPD-OSZXRS WO2025045761A1_2636 . NC[C@H]1CC[C@H](NC2=N/C3=C(Br)C=NN3/C(NCC3=CC=C(C4=NC=CC=C4)C=C3)=N\2)CC1 Degrader C24H27BrN8 CDK12;KIAA1791;CDK9;CCNK Q9NYV4/Q14004/P50750/O75909 DDB1 WO-2025045761-A1 TPD-DNYT6D WO2025104092A1_313 . CC1=CC=CC(N2C=C(C3CCN(CC4=NC=NC=C4)CC3)N=N2)=C1 Stabilizer C19H22N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-3ZOL6J WO2025104092A1_314 . CC1=CC=CC(N2C=C(C3CCN(CC4=CC=C(S(C)(=O)=O)C=C4)CC3)N=N2)=C1 Stabilizer C22H26N4O2S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-WP248P WO2025104092A1_316 . COC1=C(N2C=C(C3CCN(CC4=C(C)C=CC=C4)CC3)N=N2)C=CC=C1 Stabilizer C22H26N4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-UURPD2 WO2025104092A1_317 . CN1C=NC(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)=C1 Stabilizer C18H26F2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-JJHHWW WO2025104092A1_318 . COC1=C(N2C=C(C3CCN(CC4=C(F)C=CC=C4)CC3)N=N2)C=CC=C1 Stabilizer C21H23FN4O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-RRJ0BX WO2025104092A1_321 . CC(C)(C)N1C=C(CN2CCC(C3=CN(C4=CC=CC(C(F)(F)F)=C4)N=N3)CC2)C=N1 Stabilizer C22H27F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-J641C9 WO2025104092A1_323 . CN1N=CC(Cl)=C1CN1CCC(C2=CN(C3CCC(F)(F)CC3)N=N2)CC1 Stabilizer C18H25ClF2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-PAS64K WO2025104092A1_324 . CC1=NNC(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)=C1 Stabilizer C18H26F2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-HA9XGH WO2025104092A1_325 . CN1N=CC=C1CN1CCC(C2=CN(C3CCC(F)(F)CC3)N=N2)CC1 Stabilizer C18H26F2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-RP70BC WO2025104092A1_326 . CC1=NN(C)C(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)=C1Cl Stabilizer C19H27ClF2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-HHLJ0A WO2025104092A1_327 . CC1=NC(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)=CO1 Stabilizer C18H25F2N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-DPASC8 WO2025104092A1_334 . COC1=CN=CC(CN2CCC(C3=CN(C4=CC(C)=CC=C4)N=N3)CC2)=C1 Stabilizer C21H25N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-NXS15I WO2025104092A1_335 . CC1=NNC(CN2CCC(C3=CN(CC4CCC(F)(F)CC4)N=N3)CC2)=C1 Stabilizer C19H28F2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-9V8UKY WO2025104092A1_336 . CN1C=C(CN2CCC(C3=CN(C4=CC=CC(C(F)(F)F)=C4)N=N3)CC2)C=N1 Stabilizer C19H21F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-QVDRH5 WO2025104092A1_338 . CC1=CN=C(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)S1 Stabilizer C18H25F2N5S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-KX59O1 WO2025104092A1_339 . CN1N=CC(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)=C1Cl Stabilizer C18H25ClF2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-1M2JF1 WO2025104092A1_341 . FC1(F)CCC(N2C=C(C3CCN(CC4=CC=CN=C4)CC3)N=N2)CC1 Stabilizer C19H25F2N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-4N5879 WO2025104092A1_343 . CC1=CSC(CN2CCC(C3=CN(C4=CC(C(F)(F)F)=CC=C4)N=N3)CC2)=N1 Stabilizer C19H20F3N5S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-VGLERH WO2025104092A1_344 . CC1=CC=CC(N2C=C(C3CCN(CC4=C(F)C=NC=C4)CC3)N=N2)=C1 Stabilizer C20H22FN5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-94HSU4 WO2025104092A1_345 . CC1=C(CN2CCC(O)(C3=CN(C4=CC(Cl)=CC=C4)N=N3)CC2)NC=N1 Stabilizer C18H21ClN6O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-W4DVS8 WO2025104092A1_346 . CC1=NC(CN2CCC(C3=CN(C4=CC=CC(C(F)(F)F)=C4)N=N3)CC2)=CN1 Stabilizer C19H21F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-1DWHI0 WO2025104092A1_347 . CCN1C=C(CN2CCC(C3=CN(C4=CC=CC(C(F)(F)F)=C4)N=N3)CC2)C=N1 Stabilizer C20H23F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-U323P7 WO2025104092A1_348 . FC(F)(F)C1=CC(N2C=C(C3CCN(CC4=CNN=C4)CC3)N=N2)=CC=C1 Stabilizer C18H19F3N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-5UIPY1 WO2025104092A1_349 . CC1=CC=C(CN2CCC(C3=CN(C4=CC=CC(C(F)(F)F)=C4)N=N3)CC2)N1 Stabilizer C20H22F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-ZDHAW6 WO2025104092A1_350 . CC1=CSC(CN2CCC(C3=CN(C4=CC=CC(Cl)=C4)N=N3)CC2)=N1 Stabilizer C18H20ClN5S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-WX0FHT WO2025104092A1_351 . CN1C=C(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)C=N1 Stabilizer C18H26F2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-R9FTVL WO2025104092A1_352 . N#CC1=CC=C(N2C=C(C3CCN(CC4=C(O)C=CC=C4)CC3)N=N2)C=C1 Stabilizer C21H21N5O Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-LI7R6L WO2025104092A1_354 . FC1=CC=C(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)C=N1 Stabilizer C19H24F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-QD3LXL WO2025104092A1_355 . CN1C=CC(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)=N1 Stabilizer C18H26F2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-QRFI0N WO2025104092A1_356 . CC1=NC=C(CN2CCC(C3=CN(C4=CC=CC(Cl)=C4)N=N3)CC2)S1 Stabilizer C18H20ClN5S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-GW5NQA WO2025104092A1_357 . CC1=CC=CC(N2C=C(C3CCN(CC4=C(C)C=CC=C4C)CC3)N=N2)=C1 Stabilizer C23H28N4 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-WI5WK8 WO2025104092A1_358 . CC1=C(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)C=NN1 Stabilizer C18H26F2N6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-EIL42Y WO2025104092A1_359 . CC1=NC(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)=CS1 Stabilizer C18H25F2N5S Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-IUHPLD WO2025104092A1_360 . N#CC1=CC=C(N2C=C(C3CCN(CC4=CC=C(C(F)(F)F)C=C4)CC3)N=N2)C=C1 Stabilizer C22H20F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-CGD64N WO2025104092A1_361 . FC1=CN=CC(CN2CCC(C3=CN(C4CCC(F)(F)CC4)N=N3)CC2)=C1 Stabilizer C19H24F3N5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-HFSI86 WO2025104092A1_362 . CN1C=NC(CN2CCC(C3=CN(C4=CC=CC(Cl)=C4)N=N3)CC2)=C1 Stabilizer C18H21ClN6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-MFV16S WO2025104092A1_363 . CC1=CC=CC(N2C=C(C3CCN(CC4=C(F)C=CC=N4)CC3)N=N2)=C1 Stabilizer C20H22FN5 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-OD1HPH WO2025104092A1_364 . CN1C=C(CN2CCC(C3=CN(C4=CC=CC(Cl)=C4)N=N3)CC2)C=N1 Stabilizer C18H21ClN6 Septin 6;Septin 7 Q14141/Q16181 . WO-2025104092-A1 TPD-KMZALF WO2025129172A1_40 . CC1=C/C2=N/C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)=C(/NC3=CC4=C(C=C3)OCCO4)N2C=C1 Degrader C29H25N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-0NABRV WO2025129172A1_41 . CC1=CC=C/C2=N/C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)=C(/NC(C)(C)C)N12 Degrader C25H27N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-X26GCW WO2025129172A1_42 . CC1=CN2/C(=N\C(C3=C\C4=C(/C=C\3)C(=O)N(C3CCC(=O)NC3=O)C4)=C/2NC(C)(C)C)C=C1 Degrader C25H27N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-HLMPXJ WO2025129172A1_43 . CC1=C/C2=N/C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)=C(/NC(C)(C)C)N2C=C1 Degrader C25H27N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-HZ96OL WO2025129172A1_44 . CC1=CC=CN2/C1=N\C(C1=C\C3=C(/C=C\1)C(=O)N(C1CCC(=O)NC1=O)C3)=C/2NC(C)(C)C Degrader C25H27N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-RXHUV7 WO2025129172A1_5 . CC(C)(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=CN21 Degrader C24H25N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-VUQCMQ WO2025129172A1_6 . O=C1CCC(N2CC3=C(/C=C\C(C4=C(/NC5=CC6=C(C=C5)OCCO6)N5C=CC=C/C5=N/4)=C/3)C2=O)C(=O)N1 Degrader C28H23N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-YHP8GU WO2025129172A1_7 . CC(C)(C)OC(=O)CN/C1=C(C2=C\C3=C(/C=C\2)C(=O)N(C2CCC(=O)NC2=O)C3=O)/N=C2/N=CC=CN21 Degrader C25H24N6O6 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-XKFEOH WO2025129172A1_71 . CC(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=CN21 Degrader C23H23N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-7PU1OE WO2025129172A1_72 . C[Si](C)(C)CN/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=CC=CN21 Degrader C24H27N5O3Si WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-COM23J WO2025129172A1_73 . O=C1CCC(N2CC3=CC(C4=C(\NC5=C(C6=CC=CC=C6)C=CC=C5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C32H25N5O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-WBXK2Q WO2025129172A1_74 . O=C1CCC(N2CC3=CC(C4=C(\NC5=CC6=C(C=C5)OCO6)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C27H21N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-YDLWEP WO2025129172A1_75 . O=C1CCC(N2CC3=CC(C4=C(\NC5CCOCC5)N5C=CC=C\C5=N\4)=CC=C3C2=O)C(=O)N1 Degrader C25H25N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-VAPV5W WO2025129172A1_76 . CC(C)(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)/N=C2/C=NC=CN21 Degrader C23H24N6O3 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-MTI97B WO2025129172A1_78 . COC1=CC2=C(C=C1)N1/C(NC3=CC4=C(C=C3)OCCO4)=C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)\N=C/1S2 Degrader C31H25N5O6S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-7IUF3T WO2025129172A1_79 . COC1=CC2=C(C=C1)N1/C(NC34CC5CC(CC(C5)C3)C4)=C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)\N=C/1S2 Degrader C33H33N5O4S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-A7EE0R WO2025129172A1_8 . O=C1CCC(N2C(=O)C3=C(/C=C(C4=C(NCC5=CC=CC=C5)N5N=CC=CC5=N4)\C=C/3)C2=O)C(=O)N1 Degrader C26H20N6O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-6G1Z4N WO2025129172A1_80 . COC1=CC2=C(C=C1)N1/C(NC(C)(C)C)=C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)\N=C/1S2 Degrader C27H27N5O4S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-5R0YMU WO2025129172A1_81 . COC1=CC2=C(C=C1)N1/C(NC(C)(C)CC(C)(C)C)=C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4)\N=C/1S2 Degrader C31H35N5O4S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-3XX5NU WO2025129172A1_82 . O=C1CCC(N2CC3=C(/C=C\C(C4=C(/NCC5=CC=CC=C5)N5C=CS/C5=N/4)=C/3)C2=O)C(=O)N1 Degrader C25H21N5O3S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-93R69I WO2025129172A1_83 . COC1=CC2=C(C=C1)N1/C(NCC3=CC=CC=C3)=C(C3=C/C4=C(\C=C/3)C(=O)N(C3CCC(=O)NC3=O)C4=O)\N=C/1S2 Degrader C30H23N5O5S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-7NR9EC WO2025129172A1_9 . O=C1CCC(N2C(=O)C3=C(/C=C(C4=C(\NCC5=CC=CC=C5)N5C=CS/C5=N/4)\C=C/3)C2=O)C(=O)N1 Degrader C25H19N5O4S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-8S97B0 WO2025129172A1_90 . CC1=CC=C/C2=N/C(C3=CC4=C(C=C3)C(=O)N(C3CCC(=O)NC3=O)C4=O)=C(/NC(C)(C)CC(C)(C)C)N12 Degrader C29H33N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-EESWEK WO2025129172A1_91 . CC(C)(C)CC(C)(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)/N=C2/SC=CN12 Degrader C26H29N5O4S WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-1P2JB5 WO2025129172A1_92 . CC1=CN2C(=NC(C3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)=C2NC(C)(C)CC(C)(C)C)C=C1 Degrader C29H33N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-OKSQWW WO2025129172A1_93 . CC1=CN2/C(=N\C(C3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)=C/2NCC2=CC=CC=C2)C=C1 Degrader C28H23N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-EG11GT WO2025129172A1_94 . CC(C)(C)CC(C)(C)NC1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)N=C2C=C(F)C=CN21 Degrader C28H30FN5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-99T8TR WO2025129172A1_95 . CC(C)(C)CC(C)(C)NC1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)N=C2C=CC(F)=CN21 Degrader C28H30FN5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-8SN5HE WO2025129172A1_96 . CC(C)(C)CC(C)(C)N/C1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)/N=C2/C=C\C3=C(CCC3)N21 Degrader C31H35N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-P18CC8 WO2025129172A1_97 . CC1=C(C)N2C(=NC(C3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)=C2NC(C)(C)CC(C)(C)C)C=C1 Degrader C30H35N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-G4MPM9 WO2025129172A1_98 . COC1=CC=CC2=NC(C3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)=C(NC(C)(C)CC(C)(C)C)N12 Degrader C29H33N5O5 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-3MO1DT WO2025129172A1_99 . CC(C)(C)CC(C)(C)NC1=C(C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)N=C2/C=C\C3=C(C=CC=C3)N21 Degrader C32H33N5O4 WEE1;CK1α P30291/P48729 CRBN WO-2025129172-A1 TPD-GEAUXG WO2025137053A1_30 . COC[C@@H]1CN(CC2=CC(F)=C3/N=C\C(N4CCOCC4)=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-99BG3B SCHEMBL31623148 (3S)-3-[6-[(3S,4S)-1-[(5-fluoro-3-morpholin-4-ylquinolin-6-yl)methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C\C(N4CCOCC4)=C/C3=C2F)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-F24N3W SCHEMBL31623314 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(2-hydroxypropan-2-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C(C)(C)O)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C32H35FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-755WVN SCHEMBL31623236 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(oxan-4-yloxymethyl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(COC4CCOCC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H39FN4O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-P8T0CR SCHEMBL31623247 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[(1-methylpiperidin-4-yl)oxymethyl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(COC4CCN(C)CC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H42FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-1PR6RP SCHEMBL31623280 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(N4CCN(CC(F)(F)F)CC4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H37F4N7O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-QOS1Y0 WO2025137053A1_36 . CC(=O)N1CC(C2=NC3=C(F)/C=C(CN4C[C@@H](CO)[C@H](OC5=CC6=C(C=C5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)\C=C\3C=C2)C1 Degrader C33H34FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-8RN0AH SCHEMBL31623277 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[1-(2,2,2-trifluoroethyl)azetidin-3-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CN(CC(F)(F)F)C4)C=C/C3=C\2)C[C@H]1OC1=CC2=C(C=C1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H35F4N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-6ZGPA9 SCHEMBL31623278 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[7-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]isoquinolin-3-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=N/C=C3/C=C(C4CCN(CC(F)(F)F)CC4)C=C/C3=C\2)C[C@H]1OC1=CC2=C(C=C1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H40F3N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-E4OKCE SCHEMBL31623161 (3S)-3-[6-[(3S,4S)-4-(methoxymethyl)-1-[[7-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]isoquinolin-3-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=N/C=C3/C=C(N4CCN(CC(F)(F)F)CC4)C=C/C3=C\2)C[C@H]1OC1=CC2=C(C=C1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H39F3N6O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-8593VO WO2025137053A1_4 . CN1CC[C@]2(C[C@@H](C3=NC4=C/C=C(CN5CC[C@H](OC6=CC7=C(C=C6)C(=O)N([C@H]6CCC(=O)NC6=O)C7)C5)\C=C\4C=C3)CO2)C1 Degrader C35H39N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-MW73HF SCHEMBL31623249 (3S)-3-[6-[(3S,4S)-1-[[7-(2-hydroxypropan-2-yl)isoquinolin-3-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=N/C=C3/C=C(C(C)(C)O)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C32H36N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-JJMCXR SCHEMBL31623223 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(2-hydroxypropan-2-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C(C)(C)O)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C31H34FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-QHJZ18 SCHEMBL31623269 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(oxan-4-yloxymethyl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(COC4CCOCC4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H38FN5O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-OP297L SCHEMBL31623174 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[(1-methylpiperidin-4-yl)oxymethyl]quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(COC4CCN(C)CC4)N=C/C3=C\2)C[C@H]1OC1=CC2=C(C=C1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H41FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-PCDZE8 SCHEMBL31623137 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3N=C(N4CCN(CC(F)(F)F)CC4)C=CC3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H38F4N6O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-7637WG SCHEMBL31623285 (3S)-3-[6-[(3S,4S)-1-[[2-(1-acetylazetidin-3-yl)-8-fluoroquinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CN(C(C)=O)C4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H35FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-S2HG5H SCHEMBL31623151 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[1-(2,2,2-trifluoroethyl)azetidin-3-yl]quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CN(CC(F)(F)F)C4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H34F4N6O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-YQB7BA SCHEMBL31623299 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[(1S,5R)-6-oxa-3-azabicyclo[3.1.1]heptan-3-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(N4C[C@H]5C[C@@H](C4)O5)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-ZVYQ6F SCHEMBL31623145 (3S)-3-[6-[(3S,4S)-1-[(8-fluoro-7-morpholin-4-ylisoquinolin-3-yl)methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=N/C=C3/C(F)=C(N4CCOCC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-RWHKN5 SCHEMBL31623301 (3S)-3-[6-[(3S,4S)-1-[(5-fluoro-3-morpholin-4-ylisoquinolin-7-yl)methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/C=C(N4CCOCC4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-7LAMDQ WO2025137053A1_5 . [H][C@]12CCO[C@@]1([H])CN(C1=NC3=C/C=C(CN4C[C@@H](COC)[C@H](OC5=CC6CN([C@H]7CCC(=O)NC7=O)C(=O)C6C=C5)C4)\C=C\3C=C1)C2 Degrader C35H41N5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-813O3U SCHEMBL31623284 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(4-hydroxycyclohexyl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL31645410 COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CCC(O)CC4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H38FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-WU3QVP SCHEMBL31623311 (3S)-3-[6-[(3S,4S)-1-[[7-(4-hydroxycyclohexyl)isoquinolin-3-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=N/C=C3/C=C(C4CCC(O)CC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H40N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-W47W8N SCHEMBL31623135 (3S)-3-[6-[(3S,4S)-1-[[2-(2,6-dimethyloxan-4-yl)-8-fluoroquinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CC(C)OC(C)C4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H41FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-N94K47 SCHEMBL31623197 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(2,2,6,6-tetramethyloxan-4-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CC(C)(C)OC(C)(C)C4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C38H45FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-UKCB15 SCHEMBL31623315 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(4-hydroxycyclohexyl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CCC(O)CC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H39FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-Q39D2H SCHEMBL31623243 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(4-hydroxy-1-bicyclo[2.2.2]octanyl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C45CCC(O)(CC4)CC5)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H41FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-NJ6R5X SCHEMBL31623304 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[3-(2-hydroxypropan-2-yl)-1-bicyclo[1.1.1]pentanyl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C45CC(C(C)(C)O)(C4)C5)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H41FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-DTEATC SCHEMBL31623198 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[4-(2-hydroxypropan-2-yl)cyclohexyl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL31645728 COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CCC(C(C)(C)O)CC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C38H45FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-TIZ4EY SCHEMBL31623241 6-[[(3S,4S)-3-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-5-yl]oxy]-4-(methoxymethyl)pyrrolidin-1-yl]methyl]-8-fluoro-N,N-dimethylquinoline-2-carboxamide COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C(=O)N(C)C)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C32H34FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-CXOE4M SCHEMBL31623233 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(2-oxopyrrolidin-1-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(N4CCCC4=O)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H34FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-FSVU4U SCHEMBL31623190 (3S)-3-[6-[(3R)-1-[[2-[(3aR,6aR)-2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl]quinolin-6-yl]methyl]-4,4-difluoropyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione [H][C@]12CCO[C@@]1([H])CN(C1=NC3=C/C=C(CN4C[C@@H](OC5=C/C6=C(\C=C/5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C(F)(F)C4)\C=C\3C=C1)C2 Degrader C33H33F2N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-P4ND6Y SCHEMBL31623152 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(4-hydroxyoxan-4-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4(O)CCOCC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H37FN4O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-W5B2SX SCHEMBL31623288 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(2-oxopyrrolidin-1-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(N4CCCC4=O)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C32H33FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-P19EWV SCHEMBL31623290 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(4-hydroxyoxan-4-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4(O)CCOCC4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-VX04MV SCHEMBL31623294 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(4-hydroxypiperidin-1-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCC(O)CC4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-MR18OE SCHEMBL31623204 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(4-hydroxypiperidin-1-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCC(O)CC4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H38FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-9OJC87 SCHEMBL31623180 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(1-methylpyrrolidin-2-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCCN4C)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H38FN5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-VUKXMX SCHEMBL31623310 (3S)-3-[6-[(3S,4S)-1-[[2-(1-acetylpyrrolidin-3-yl)-8-fluoroquinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCN(C(C)=O)C4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H38FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-NADQH7 SCHEMBL31623240 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCN(CC(F)(F)F)C4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H37F4N5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-SL7PNU SCHEMBL31623256 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(oxan-2-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CCCCO4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H37FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-1YB1T2 WO2025137053A1_7 . [H][C@]12CCO[C@@]1([H])CN(C1=NC3=C(F)/C=C(CN4CC[C@H](OC5=CC6=C(C=C5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)\C=C\3C=C1)C2 Degrader C33H34FN5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-TV5IYC SCHEMBL31623184 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(oxan-3-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(C4CCCOC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H37FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-7VB9OZ SCHEMBL31623188 (3S)-3-[6-[(3S,4S)-1-[(4-fluoro-7-morpholin-4-ylisoquinolin-3-yl)methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=N/C=C3\C=C(N4CCOCC4)C=C\C3=C\2F)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-LLPPHI SCHEMBL31623316 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(7-oxa-1-azaspiro[3.5]nonan-1-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCC45CCOCC5)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H40FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-MRMGAT SCHEMBL31623297 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(7-oxa-1-azaspiro[3.5]nonan-1-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCC45CCOCC5)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H39FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-AKUKF6 SCHEMBL31623267 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(6-oxa-1-azaspiro[3.3]heptan-1-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCC45COC5)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H35FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-EGMJ13 SCHEMBL31623328 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(6-oxa-1-azaspiro[3.3]heptan-1-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCC45COC5)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-7VH4DQ SCHEMBL31623318 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(oxolan-2-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; SCHEMBL31645594 COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCCO4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C32H34FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-BJKQZT SCHEMBL31623147 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(1-methylpyrrolidin-2-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCCN4C)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H37FN6O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-QCO464 SCHEMBL31623320 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(oxan-3-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCCOC4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-MI4ON4 SCHEMBL31623142 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(4-oxa-7-azaspiro[2.5]octan-7-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCOC5(CC5)C4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H37FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-UUZJGB WO2025137053A1_8 . [H][C@]12CCO[C@@]1([H])CN(C1=NC3=C/C=C(CN4C[C@@H](COC)[C@H](OC5=C/C6=C(\C=C/5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)\C=C\3C=N1)C2 Degrader C34H38N6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-Z3POVO SCHEMBL31623312 (3S)-3-[6-[(3S,4S)-1-[[2-(2,5-dioxa-8-azaspiro[3.5]nonan-8-yl)-8-fluoroquinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCOC5(COC5)C4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H37FN6O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-48SO6Q SCHEMBL31623274 (3S)-3-[6-[(3S)-1-[[2-[(3aS,6aS)-2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl]-8-fluoroquinolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione [H][C@@]12CCO[C@]1([H])CN(C1=N/C3=C(F)C=C(CN4CC[C@H](OC5=C/C6=C(\C=C/5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)C=C3/C=C\1)C2 Degrader C33H34FN5O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-ZK6R5J SCHEMBL31623192 (3S)-3-[6-[(3S,4S)-1-[[2-(1-acetyl-2,2-dimethylpiperidin-4-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C(C4CCN(C(C)=O)C(C)(C)C4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H44N6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-6HC15X SCHEMBL31623275 (3S)-3-[6-[(3S,4R)-1-[[8-fluoro-2-(oxan-4-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@H]1CN(CC2=C/C(F)=C3/N=C(C4CCOCC4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H37FN4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-YP61TF SCHEMBL31623292 (3S)-3-[6-[(3S,4S)-1-[[2-(2,2-dimethyloxan-4-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C=C3/N=C(C4CCOC(C)(C)C4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H42N4O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-0EJTIQ SCHEMBL31623237 (3S)-3-[6-[(3S,4S)-1-[[2-(4-acetyl-4,7-diazaspiro[2.5]octan-7-yl)-8-fluoroquinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(N4CCN(C(C)=O)C5(CC5)C4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H40FN7O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-1CWV99 SCHEMBL31623295 (3S)-3-[6-[(3S,4S)-1-[[2-(5-acetyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-8-fluoroquinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C(F)=C3/N=C(N4CCN(C(C)=O)C5(COC5)C4)N=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H40FN7O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-49RS5U SCHEMBL31623215 (3S)-3-[6-[(3S,4S)-1-[[7-(5-acetyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)isoquinolin-3-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=N/C=C3/C=C(N4CCN(C(C)=O)C5(COC5)C4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H42N6O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-QZVKOR SCHEMBL31623156 (3S)-3-[6-[(3S,4S)-1-[[7-(4-acetyl-4,7-diazaspiro[2.5]octan-7-yl)isoquinolin-3-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=N/C=C3/C=C(N4CCN(C(C)=O)C5(CC5)C4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H42N6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-YBSLLS SCHEMBL31623144 (3S)-3-[6-[(3S,4S)-1-[[2-(4-acetyl-4,7-diazaspiro[2.5]octan-7-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C=C3/N=C(N4CCN(C(C)=O)C5(CC5)C4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H42N6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-02T8GS SCHEMBL31623266 (3S)-3-[6-[(3S)-1-[[2-[(3aR,6aR)-2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl]-8-fluoroquinazolin-6-yl]methyl]pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione [H][C@]12CCO[C@@]1([H])CN(C1=NC3=C(F)/C=C(CN4CC[C@H](OC5=CC6=C(C=C5)C(=O)N([C@H]5CCC(=O)NC5=O)C6)C4)\C=C\3C=N1)C2 Degrader C32H33FN6O5 WEE1 P30291 CRBN WO-2025137053-A1 TPD-T2I2VG SCHEMBL31623208 (3S)-3-[6-[(3S,4S)-1-[[2-(5-acetyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=C/C=C3/N=C(N4CCN(C(C)=O)C5(COC5)C4)C=C/C3=C\2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H42N6O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-YFG1DF SCHEMBL31623218 (3S)-3-[6-[(3S,4S)-1-[[2-(2,2-dimethyloxan-4-yl)-8-fluoroquinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCOC(C)(C)C4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C35H40FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-H942ZA SCHEMBL31623282 (3S)-3-[6-[(3S,4S)-1-[[2-(4-acetyl-4,7-diazaspiro[2.5]octan-7-yl)-8-fluoroquinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCN(C(C)=O)C5(CC5)C4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H41FN6O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-DRKO2J SCHEMBL31623222 (3S)-3-[6-[(3S,4S)-1-[[2-(5-acetyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-8-fluoroquinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CCN(C(C)=O)C5(COC5)C4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C37H41FN6O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-MOBLER SCHEMBL31623221 (3S)-3-[6-[(3S,4S)-1-[[2-(4-acetyl-4,7-diazaspiro[2.5]octan-7-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C(N4CCN(C(C)=O)C5(CC5)C4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H41N7O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-R48Z32 SCHEMBL31623213 (3S)-3-[6-[(3S,4S)-1-[[2-(5-acetyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC=C3/N=C(N4CCN(C(C)=O)C5(COC5)C4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C36H41N7O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-P7CC4H SCHEMBL31623321 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-(oxan-2-yl)quinazolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(C4CCCCO4)\N=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C33H36FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-XS1VMU SCHEMBL31623172 (3S)-3-[6-[(3S,4S)-1-[[8-fluoro-2-[(3R)-3-methoxypyrrolidin-1-yl]quinolin-6-yl]methyl]-4-(methoxymethyl)pyrrolidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CC[C@@H](OC)C4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H38FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-HXESI2 WO2025137053A1_98 . COC[C@@H]1CN(CC2=CC(F)=C3/N=C(N4CC[C@H](OC)C4)\C=C/C3=C2)C[C@H]1OC1=C/C2=C(\C=C/1)C(=O)N([C@H]1CCC(=O)NC1=O)C2 Degrader C34H38FN5O6 WEE1 P30291 CRBN WO-2025137053-A1 TPD-TVYMNB WO2025137053A1_99 . O=C(O)CC(CCO)C1=N/C2=C(F)C=C(CN3CC[C@H](OC4=C/C5=C(\C=C/4)C(=O)N([C@H]4CCC(=O)NC4=O)C5)C3)C=C2/C=C\1 Degrader C32H33FN4O7 WEE1 P30291 CRBN WO-2025137053-A1 TPD-LU8Z54 CN-113461678-B_CRSM C1=CC=C(OC2=CC=CC(CNC3=CC4C5=C(C=CC=C5)NC4C=N3)=C2)C=C1 Stabilizer C24H21N3O α-tubulin;Beta-tubulin Q71U36/P07437 . CN-113461678-B TPD-POCAA2 CN-118697728-A_ATS [H][C@]1(OC(=O)CCC(=O)NCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@]3([H])NC(=O)N[C@]23[H])O[C@]2([H])O[C@](C)(O)CC[C@]3([H])[C@H](C)CC[C@@]([H])([C@H]1C)[C@@]23O Degrader C35H58N4O11S LONP1 P36776 . CN-118697728-A